intranasal administration


Summary: The administration of drugs through the nasal passage.

Top Publications

  1. ncbi Oxytocin improves "mind-reading" in humans
    Gregor Domes
    Department of Psychiatry and Psychotherapy, Rostock University, Rostock, Germany
    Biol Psychiatry 61:731-3. 2007
  2. ncbi Sniffing neuropeptides: a transnasal approach to the human brain
    Jan Born
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Nat Neurosci 5:514-6. 2002
  3. ncbi Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration
    R G Thorne
    Department of Pharmaceutics, University of Minnesota, Minneapolis, MN 55455, USA
    Neuroscience 127:481-96. 2004
  4. ncbi Brain uptake of the glucagon-like peptide-1 antagonist exendin(9-39) after intranasal administration
    William A Banks
    Geriatric Research, Education and Clinical Center, Veterans Affairs Medical Center St Louis, Missouri, USA
    J Pharmacol Exp Ther 309:469-75. 2004
  5. ncbi The effect of intranasal administration of oxytocin on fear recognition
    M Fischer-Shofty
    Department of Psychology, University of Haifa, Haifa 31905, Israel
    Neuropsychologia 48:179-84. 2010
  6. ncbi Intranasal administration of oxytocin increases envy and schadenfreude (gloating)
    Simone G Shamay-Tsoory
    Department of Psychology, University of Haifa, Haifa, Israel
    Biol Psychiatry 66:864-70. 2009
  7. ncbi Effect of intranasal administration of Lactobacillus pentosus S-PT84 on influenza virus infection in mice
    Takayuki Izumo
    Institute for Health Care Science, Suntory Wellness Limited, 1 1 1 Wakayamadai, Shimamoto cho, Mishima gun, Osaka 618 8503, Japan
    Int Immunopharmacol 10:1101-6. 2010
  8. ncbi Recent patents review on intranasal administration for CNS drug delivery
    Viral Jogani
    TIFAC CORE IN NDDS, Pharmacy Department, Faculty of Technology and Engineering, The Maharaja Sayajirao University of Baroda, Kalabhavan, Vadodara, Gujarat State, India
    Recent Pat Drug Deliv Formul 2:25-40. 2008
  9. ncbi Single intranasal administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in C57BL/6 mice models early preclinical phase of Parkinson's disease
    Rui D S Prediger
    Departamento de Farmacologia, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, UFSC, Florianopolis, SC, Brazil
    Neurotox Res 17:114-29. 2010
  10. ncbi Intranasal administration with NAD+ profoundly decreases brain injury in a rat model of transient focal ischemia
    Weihai Ying
    Department of Neurology, University of California at San Francisco and San Francisco Veterans Affairs Medical Center 4150 Clement Street, San Francisco, CA 94121, USA
    Front Biosci 12:2728-34. 2007

Detail Information

Publications320 found, 100 shown here

  1. ncbi Oxytocin improves "mind-reading" in humans
    Gregor Domes
    Department of Psychiatry and Psychotherapy, Rostock University, Rostock, Germany
    Biol Psychiatry 61:731-3. 2007
    ..The neuropeptide oxytocin plays a central role in social approach behavior in nonhuman mammals...
  2. ncbi Sniffing neuropeptides: a transnasal approach to the human brain
    Jan Born
    Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Nat Neurosci 5:514-6. 2002
  3. ncbi Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration
    R G Thorne
    Department of Pharmaceutics, University of Minnesota, Minneapolis, MN 55455, USA
    Neuroscience 127:481-96. 2004
    ..65 kDa protein neurotrophic factor, following intranasal administration and the possible pathways and mechanisms underlying transport from the nasal passages to the CNS...
  4. ncbi Brain uptake of the glucagon-like peptide-1 antagonist exendin(9-39) after intranasal administration
    William A Banks
    Geriatric Research, Education and Clinical Center, Veterans Affairs Medical Center St Louis, Missouri, USA
    J Pharmacol Exp Ther 309:469-75. 2004
    ..We found that olfactory bulb uptake of I-Ex after intranasal administration was rapid, much greater than after i.v...
  5. ncbi The effect of intranasal administration of oxytocin on fear recognition
    M Fischer-Shofty
    Department of Psychology, University of Haifa, Haifa 31905, Israel
    Neuropsychologia 48:179-84. 2010
    ..The results showed that a single intranasal administration of oxytocin, as opposed to the placebo, improved the subjects' ability to recognize fear, but not other ..
  6. ncbi Intranasal administration of oxytocin increases envy and schadenfreude (gloating)
    Simone G Shamay-Tsoory
    Department of Psychology, University of Haifa, Haifa, Israel
    Biol Psychiatry 66:864-70. 2009
    ..Given the important social components of envy and gloating, we speculated that oxytocin may have a modulating effect on the intensity of these emotions...
  7. ncbi Effect of intranasal administration of Lactobacillus pentosus S-PT84 on influenza virus infection in mice
    Takayuki Izumo
    Institute for Health Care Science, Suntory Wellness Limited, 1 1 1 Wakayamadai, Shimamoto cho, Mishima gun, Osaka 618 8503, Japan
    Int Immunopharmacol 10:1101-6. 2010
    ..In the present study, we investigated whether the immune response could be activated by intranasal administration of S-PT84 in the respiratory immune system and protected against influenza virus infection in mice...
  8. ncbi Recent patents review on intranasal administration for CNS drug delivery
    Viral Jogani
    TIFAC CORE IN NDDS, Pharmacy Department, Faculty of Technology and Engineering, The Maharaja Sayajirao University of Baroda, Kalabhavan, Vadodara, Gujarat State, India
    Recent Pat Drug Deliv Formul 2:25-40. 2008
    ..A critical review of recent patents claiming different approaches for enhanced brain delivery through the nasal route will help in determining the focus of this promising area of research...
  9. ncbi Single intranasal administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in C57BL/6 mice models early preclinical phase of Parkinson's disease
    Rui D S Prediger
    Departamento de Farmacologia, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, UFSC, Florianopolis, SC, Brazil
    Neurotox Res 17:114-29. 2010
    ..n. administration of MPTP represents a valuable mouse model for the study of the early stages of PD and for testing new therapeutic strategies to restore sensorial and cognitive processes in PD...
  10. ncbi Intranasal administration with NAD+ profoundly decreases brain injury in a rat model of transient focal ischemia
    Weihai Ying
    Department of Neurology, University of California at San Francisco and San Francisco Veterans Affairs Medical Center 4150 Clement Street, San Francisco, CA 94121, USA
    Front Biosci 12:2728-34. 2007
    ..In contrast, intranasal administration with 10 mg/kg nicotinamide did not decrease ischemic brain damage...
  11. pmc Protective immune responses to a recombinant adenovirus type 35 tuberculosis vaccine in two mouse strains: CD4 and CD8 T-cell epitope mapping and role of gamma interferon
    Katarina Radosevic
    Crucell Holland BV, Archimedesweg 4 6, 2333 CN Leiden, The Netherlands
    Infect Immun 75:4105-15. 2007
    ..These results unify conflicting reports on the relative importance of CD4 versus CD8 T-cell responses in protection and emphasize the key role of IFN-gamma...
  12. ncbi Intranasal mupirocin to prevent postoperative Staphylococcus aureus infections
    Trish M Perl
    University of Iowa Colleges of Medicine and Public Health, Iowa City, USA
    N Engl J Med 346:1871-7. 2002
    ..Treatment with mupirocin ointment can reduce the rate of nasal carriage and may prevent postoperative S. aureus infections...
  13. ncbi Protection against multiple influenza A virus subtypes by intranasal administration of recombinant nucleoprotein
    Lina Guo
    Shanghai Institute of Biological Products, China
    Arch Virol 155:1765-75. 2010
    ..The results indicate that such a vaccine administered intranasally can induce mucosal and cell-mediated immunity, thus having the potential to control epidemics caused by new emerging influenza viruses...
  14. pmc Intranasal administration of nerve growth factor (NGF) rescues recognition memory deficits in AD11 anti-NGF transgenic mice
    Roberta De Rosa
    Lay Line Genomics S p A, Via di Castel Romano 100, 00128 Rome, Italy
    Proc Natl Acad Sci U S A 102:3811-6. 2005
    ..We previously showed that intranasal administration of NGF determined an amelioration of cholinergic deficit and a decrease in the number of phosphotau-..
  15. ncbi Pancreatic beta-cell function and immune responses to insulin after administration of intranasal insulin to humans at risk for type 1 diabetes
    Leonard C Harrison
    Autoimmunity and Transplantation Division, The WalterEliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3050, Victoria, Australia
    Diabetes Care 27:2348-55. 2004
  16. pmc Intranasal administration of alpha interferon reduces seasonal influenza A virus morbidity in ferrets
    Daniela Kugel
    Department of Virology, University of Freiburg, Freiburg, Germany
    J Virol 83:3843-51. 2009
    ..Based on these results, a more intensive evaluation of IFN-alpha as an emergency drug against pandemic influenza A is warranted...
  17. pmc Immunization with Staphylococcus aureus clumping factor B, a major determinant in nasal carriage, reduces nasal colonization in a murine model
    Adam C Schaffer
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Infect Immun 74:2145-53. 2006
    ..aureus nasal colonization in humans, which in turn may diminish the risk of staphylococcal infection. As targets for vaccine development and antimicrobial intervention are assessed, rodent nasal colonization models may be invaluable...
  18. ncbi Intranasal administration of Lactobacillus rhamnosus GG protects mice from H1N1 influenza virus infection by regulating respiratory immune responses
    G Harata
    Technical Research Laboratory, Takanashi Milk Products Co, Ltd, Yokohama, Kanagawa, Japan
    Lett Appl Microbiol 50:597-602. 2010
    ..To investigate whether intranasal Lactobacillus administration protects host animals from influenza virus (IFV) infection by enhancing respiratory immune responses in a mouse model...
  19. ncbi Intranasal delivery: physicochemical and therapeutic aspects
    Henry R Costantino
    Nastech Pharmaceutical Company, Inc, Bothell, WA 98021, USA
    Int J Pharm 337:1-24. 2007
    ..Case examples are provided to illustrate the utility of IN dosing. It is anticipated that the present review will prove useful for formulation scientists considering IN delivery as a delivery route...
  20. ncbi Mucosal vaccine delivery of antigens tightly bound to an adjuvant particle made from food-grade bacteria
    Maarten L van Roosmalen
    BiOMaDe Technology Foundation, Nijenborgh 4, 9747 AG Groningen, The Netherlands
    Methods 38:144-9. 2006
    ..The GEM-based vaccines do not require additional adjuvant for eliciting high levels of specific antibodies in mucosal and systemic compartments...
  21. ncbi Use of the inactivated intranasal influenza vaccine and the risk of Bell's palsy in Switzerland
    Margot Mutsch
    Division of Communicable Diseases, World Health Organization Collaborating Centre for Travellers Health, Institute of Social and Preventive Medicine, University of Zurich, Zurich, Switzerland
    N Engl J Med 350:896-903. 2004
    ..After the introduction of an inactivated intranasal influenza vaccine that was used only in Switzerland, 46 cases of Bell's palsy were reported...
  22. ncbi Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress
    Markus Heinrichs
    Department of Clinical Psychology, University of Zurich, Zurich, Switzerland
    Biol Psychiatry 54:1389-98. 2003
    ..This study was designed to determine the effects of social support and oxytocin on cortisol, mood, and anxiety responses to psychosocial stress in humans...
  23. ncbi Intranasal insulin improves memory in humans: superiority of insulin aspart
    Christian Benedict
    Department of Neuroendocrinology, University of Lubeck, Lubeck, Germany
    Neuropsychopharmacology 32:239-43. 2007
    There is compelling evidence that intranasal administration of regular human insulin (RH-I) improves memory in humans...
  24. ncbi The vaccinia virus C12L protein inhibits mouse IL-18 and promotes virus virulence in the murine intranasal model
    Julian A Symons
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, UK
    J Gen Virol 83:2833-44. 2002
    ..However, infection of BALB/c mice by the intranasal route showed that the deletion mutant was attenuated and induced lower weight loss and signs of illness compared to controls...
  25. pmc Novel surface display system for proteins on non-genetically modified gram-positive bacteria
    Tjibbe Bosma
    BiOMaDe Technology, Nijenborgh 4, 9747 AG Groningen, The Netherlands
    Appl Environ Microbiol 72:880-9. 2006
    ..The versatility and flexibility of the display and delivery technology were demonstrated by investigating enzyme immobilization and nasal vaccine applications...
  26. ncbi Intranasal administration of interferon beta bypasses the blood-brain barrier to target the central nervous system and cervical lymph nodes: a non-invasive treatment strategy for multiple sclerosis
    T M Ross
    Alzheimer s Research Center, Regions Hospital, 640 Jackson St, St Paul, MN 55101, USA
    J Neuroimmunol 151:66-77. 2004
    ..b>Intranasal administration resulted in significant delivery throughout the CNS and cervical lymph nodes with low delivery to ..
  27. ncbi Intranasal administration of CpG induces a rapid and transient cytokine response followed by dendritic and natural killer cell activation and recruitment in the mouse lung
    Isabella Pesce
    Department of Immunology, Novartis Vaccines Research Center, Siena, Italy
    J Innate Immun 2:144-59. 2010
  28. ncbi Intranasal administration of CpG oligonucleotides induces mucosal and systemic Type 1 immune responses and adjuvant activity to porcine reproductive and respiratory syndrome killed virus vaccine in piglets in vivo
    Linghua Zhang
    Microbiological Staff Room, College of Life Sciences, South China Agricultural University, Wushan Road, Tianhe District, Guangzhou, Guangdong, 510642, People s Republic of China
    Int Immunopharmacol 7:1732-40. 2007
    ..Results from this study indicate that stimulatory CpG ODN may be effective as a mucosal adjuvant with commercial vaccine in husbandry animals...
  29. ncbi Microsphere translocation and immunopotentiation in systemic tissues following intranasal administration
    J E Eyles
    DERA (Chemical and Biological Defence Sector, Porton Down, Wiltshire SP4 OJQ, Salisbury, UK
    Vaccine 19:4732-42. 2001
  30. ncbi Characterization of airway nitric oxide in allergic rhinitis: the effect of intranasal administration of L-NAME
    J P Palm
    Department of Physiology and Pharmacology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Allergy 58:885-92. 2003 investigate this further by studying airway NO in AR and controls at several modalities, and also the effect of intranasal administration of the nitric oxide synthase (NOS) inhibitor NG-nitro-L-arginine-methyl ester.HCl (L-NAME).
  31. pmc Effects of intranasal administration of a leptin-secreting Lactococcus lactis recombinant on food intake, body weight, and immune response of mice
    Luis G Bermúdez-Humarán
    Unité d Ecologie et de Physiologie du Système Digestif, INRA, Domaine de Vilvert, 78352 Jouy en Josas Cedex, France
    Appl Environ Microbiol 73:5300-7. 2007
    ..These results demonstrate that leptin can be produced and secreted in an active form by L. lactis and that leptin-producing L. lactis regulates in vivo antigen-specific immune responses, as well as body weight and food consumption...
  32. pmc Characterization of protective mucosal and systemic immune responses elicited by pneumococcal surface protein PspA and PspC nasal vaccines against a respiratory pneumococcal challenge in mice
    D M Ferreira
    Centro de Biotecnologia, Instituto Butantan, Sao Paulo, Brazil
    Clin Vaccine Immunol 16:636-45. 2009
  33. ncbi Ketamine as an analgesic: parenteral, oral, rectal, subcutaneous, transdermal and intranasal administration
    Robert H Kronenberg
    Thunderbird Samaritan Medical Center, Glendale, AZ 85306, USA
    J Pain Palliat Care Pharmacother 16:27-35. 2002
    ..A transdermal formulation is currently under patent review in Brazil and an intranasal formulation is currently undergoing phase I/II clinical trials...
  34. ncbi Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: a double-blind, randomised controlled trial
    Kirsti Näntö-Salonen
    Department of Paediatrics, University of Turku, Turku, Finland
    Lancet 372:1746-55. 2008
    ..We investigated whether administration of nasal insulin decreased the incidence of type 1 diabetes, in children with HLA genotypes and autoantibodies increasing the risk of the disease...
  35. pmc Efficacy of intranasal administration of a truncated NS1 modified live influenza virus vaccine in swine
    Amy L Vincent
    Virus and Prion Diseases of Livestock Research Unit, National Animal Disease Center, USDA, Agricultural Research Service, Ames, IA 50010, United States
    Vaccine 25:7999-8009. 2007
    ..However, there appeared to be substantial cross-reactivity in antibodies at the mucosal level with the CO99 virus in MLV vaccinated pigs...
  36. ncbi Intranasal insulin improves cognition and modulates beta-amyloid in early AD
    M A Reger
    Department of Psychiatry and Behavioral Science, University of Washington School of Medicine, Seattle, WA, USA
    Neurology 70:440-8. 2008
    ..After intranasal administration, insulin-like peptides follow extracellular pathways to the brain within 15 minutes.
  37. ncbi Single mucosal, but not parenteral, immunization with recombinant adenoviral-based vaccine provides potent protection from pulmonary tuberculosis
    Jun Wang
    Department of Pathology and Molecular Medicine and Division of Infectious Diseases, Centre for Gene Therapeutics, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5
    J Immunol 173:6357-65. 2004
    ..Our study also lends strong evidence that respiratory mucosal vaccination is critically advantageous over systemic routes of vaccination against TB...
  38. pmc Intranasal administration of IGF-1 attenuates hypoxic-ischemic brain injury in neonatal rats
    Shuying Lin
    Department of Pediatrics, Division of Newborn Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA
    Exp Neurol 217:361-70. 2009
    To determine whether intranasal administration (iN) of recombinant human insulin-like growth factor-1 (rhIGF-1) provides neuroprotection to the neonatal rat brain following cerebral hypoxia-ischemia (HI), two doses of rhIGF-1 (50 microg ..
  39. pmc Intranasal inoculation of mice with Yersinia pseudotuberculosis causes a lethal lung infection that is dependent on Yersinia outer proteins and PhoP
    Michael L Fisher
    Department of Microbiology, 136 Harrison Ave, Tufts University, Boston, MA 02111, USA
    Infect Immun 75:429-42. 2007
    ..Furthermore, this lung infection model with Y. pseudotuberculosis can be used to test potential therapeutics against Yersinia and other gram-negative infections in lungs...
  40. ncbi Nasal vaccines
    S S Davis
    Institute of Pharmaceutical Sciences, University of Nottingham, Boots Science Building, Science Road, University Park, NG7 2RD, Nottingham, UK
    Adv Drug Deliv Rev 51:21-42. 2001
    ..The immune response following intranasal administration can provide protection at the administration site and at various effector sites as part of the common ..
  41. ncbi Size dependent immune response after subcutaneous, oral and intranasal administration of BSA loaded nanospheres
    I Gutierro
    Laboratory of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of the Basque Country UPV EHU, Paseo de la Universidad no 7, 01006, Vitoria Gasteiz, Spain
    Vaccine 21:67-77. 2002
    ..differences on the serum IgG2a/IgG1 ratios were found after the subcutaneous, the oral and the intranasal administration of the different spheres but those were in general higher compared to the administration of either free ..
  42. pmc Intranasal vaccination with a secreted chlamydial protein enhances resolution of genital Chlamydia muridarum infection, protects against oviduct pathology, and is highly dependent upon endogenous gamma interferon production
    Ashlesh K Murthy
    Department of Biology, University of Texas at San Antonio, 6900N Loop 1604W, San Antonio, TX 78249, USA
    Infect Immun 75:666-76. 2007
    ..Together, these results demonstrate that secreted chlamydial antigens may be novel vaccine candidates to induce protective immunity...
  43. ncbi Lectin-conjugated PEG-PLA nanoparticles: preparation and brain delivery after intranasal administration
    Xiaoling Gao
    Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 200032, China
    Biomaterials 27:3482-90. 2006
    ..Thus, the technique offered a novel effective noninvasive system for brain drug delivery, especially for brain protein and gene delivery...
  44. ncbi Potential of nanoparticulate drug delivery systems by intranasal administration
    Javed Ali
    Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India
    Curr Pharm Des 16:1644-53. 2010
  45. pmc Effect of intranasal administration of Lactobacillus casei Shirota on influenza virus infection of upper respiratory tract in mice
    T Hori
    Yakult Central Institute for Microbiological Research, 1796 Yaho, Kunitachi, Tokyo 1868650, Japan
    Clin Diagn Lab Immunol 8:593-7. 2001
    ..infection model with modifications, we investigated whether the survival rate of mice was increased by intranasal administration of LcS. The survival rate of the mice in the LcS 200 group was significantly (P < 0...
  46. ncbi Cross-protection against influenza virus infection by intranasal administration of M2-based vaccine with chitosan as an adjuvant
    Zhiwei Sui
    State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, Hubei, China
    Arch Virol 155:535-44. 2010
    ..The study indicated that the sM2 protein was a candidate antigen for a broad-spectrum influenza virus vaccine and that the adjuvant chitosan improved the efficacy of the sM2 vaccine...
  47. ncbi Single dose intranasal immunization with ISCOMATRIX vaccines to elicit antibody-mediated clearance of influenza virus requires delivery to the lower respiratory tract
    Megan T Sanders
    Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia
    Vaccine 27:2475-82. 2009
    ..Good protective responses can thus be achieved with only a single intranasal inoculation of influenza vaccine formulated with adjuvant, providing the vaccine can access sites of immune induction in the lower respiratory tract...
  48. ncbi alpha-Galactosylceramide can act as a nasal vaccine adjuvant inducing protective immune responses against viral infection and tumor
    Sung Youl Ko
    Laboratory of Immunology, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Korea
    J Immunol 175:3309-17. 2005
    ..In addition, intranasal administration of OVA with alpha-GalCer showed complete protection against EG7 tumor challenge in C57BL/6...
  49. ncbi Intranasal NAP administration reduces accumulation of amyloid peptide and tau hyperphosphorylation in a transgenic mouse model of Alzheimer's disease at early pathological stage
    Yasuji Matsuoka
    Department of Neurology, Georgetown University Medical Center, Washington, DC 20057, USA
    J Mol Neurosci 31:165-70. 2007
    ..Our results indicate that NAP treatment of transgenic mice initiated at an early stage reduced both Abeta and tau pathology, suggesting that NAP might be a potential therapeutic agent for AD...
  50. ncbi Hierarchical suppression of asthma-like responses by mucosal tolerance
    Alexandre C Keller
    Department of Immunology, Biomedical Science Institute, University of Sao Paulo, Brazil
    J Allergy Clin Immunol 117:283-90. 2006
    ..Mucosal tolerance can be induced by oral or nasal administration of soluble proteins and results in the suppression of cellular and/or humoral immune responses to the specific antigen...
  51. ncbi Protection against influenza virus infection in polymeric Ig receptor knockout mice immunized intranasally with adjuvant-combined vaccines
    Yasuko Asahi
    Department of Pathology, National Institute of Infectious Diseases, Yakult Central Institute for Microbiological Research, and Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Immunol 168:2930-8. 2002
  52. ncbi Does intranasal application of zinc sulfate produce anosmia in the mouse? An olfactometric and anatomical study
    Kathleen McBride
    Department of Psychology, American University, Washington, DC 20016, USA
    Chem Senses 28:659-70. 2003
  53. ncbi Intranasal delivery of morphine
    L Illum
    West Pharmaceutical Services, Drug Delivery and Clinical Research Centre Ltd, Albert Einstein Centre, Nottingham Science and Technology Park, Nottingham, United Kingdom
    J Pharmacol Exp Ther 301:391-400. 2002
    ..It is concluded that a properly designed nasal morphine formulation (such as one with chitosan) can result in a non-injectable opioid product capable of offering patients rapid and efficient pain relief...
  54. ncbi Intranasal administration of adjuvant-combined vaccine protects monkeys from challenge with the highly pathogenic influenza A H5N1 virus
    Takeshi Ichinohe
    Department of Pathology, National Institute of Infectious Diseases, Musashimurayama shi, Tokyo, Japan
    J Med Virol 82:1754-61. 2010
    The effectiveness in cynomolgus macaques of intranasal administration of an influenza A H5N1 pre-pandemic vaccine combined with synthetic double-stranded RNA (polyI/polyC12U) as an adjuvant was examined...
  55. ncbi Influenza virus: immunity and vaccination strategies. Comparison of the immune response to inactivated and live, attenuated influenza vaccines
    R J Cox
    Influenza Research Centre Broegelmann Research Laboratory, The Gade Institute, University of Bergen, Bergen, Norway
    Scand J Immunol 59:1-15. 2004
    ..In contrast, the CAV may elicit a long-lasting, broader immune (humoral and cellular) response, which more closely resembles natural immunity. The immune response induced by these two vaccines will be compared in this review...
  56. ncbi Intranasal administration of human IL-6 increases the severity of chemically induced seizures in rats
    Allan V Kalueff
    Medical School, University of Tampere, 33014, Finland
    Neurosci Lett 365:106-10. 2004
    ..Our findings show that IL-6 plays a pro-convulsant role in the brain and suggest that the IL-6 system may be a novel target for the development of anticonvulsant drugs...
  57. pmc Clinical protection against caprine herpesvirus 1 genital infection by intranasal administration of a live attenuated glycoprotein E negative bovine herpesvirus 1 vaccine
    Julien Thiry
    Department of Animal Health and Well Being, Faculty of Veterinary Medicine, University of Bari, 70010 Valenzano, Italy
    BMC Vet Res 3:33. 2007
  58. ncbi Intranasal treatment with ovalbumin but not the major T cell epitope ovalbumin 323-339 generates interleukin-10 secreting T cells and results in the induction of allergen systemic tolerance
    C Barbey
    Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Clin Exp Allergy 34:654-62. 2004
    ..Nasal administration of major peptide T cell epitopes gives contradictory data on the induction of peripheral tolerance...
  59. ncbi A new intranasal influenza vaccine based on a novel polycationic lipid--ceramide carbamoyl-spermine (CCS) I. Immunogenicity and efficacy studies in mice
    Aviva Joseph
    The Lautenberg Center for General and Tumor Immunology, The Hebrew University Hadassah Medical School, P O Box 12272, Jerusalem 91120, Israel
    Vaccine 24:3990-4006. 2006
    ..n. with the CCS vaccine formulation. A similar approach may prove efficacious for i.n. vaccination against other pathogens...
  60. ncbi Nasal lymphoid tissue, intranasal immunization, and compartmentalization of the common mucosal immune system
    H Y Wu
    Department of Microbiology, University of Alabama at Birmingham, USA
    Immunol Res 16:187-201. 1997
  61. ncbi Delivery of interferon-beta to the monkey nervous system following intranasal administration
    R G Thorne
    Department of Pharmaceutics, University of Minnesota, Minneapolis, MN 55455, USA
    Neuroscience 152:785-97. 2008
    ..a 20 kDa protein used to treat the relapsing-remitting form of multiple sclerosis, following intranasal administration in anesthetized, adult cynomolgus monkeys...
  62. ncbi Oxytocin increases trust in humans
    Michael Kosfeld
    University of Zurich, Institute for Empirical Research in Economics, Blumlisalpstrasse 10, CH 8006 Zurich, Switzerland
    Nature 435:673-6. 2005
    ..Little is known, however, about the biological basis of trust among humans. Here we show that intranasal administration of oxytocin, a neuropeptide that plays a key role in social attachment and affiliation in non-human ..
  63. ncbi Intranasal administration of a PARG inhibitor profoundly decreases ischemic brain injury
    Guangwei Wei
    Department of Neurology, San Francisco Veterans Affairs Medical Center and the University of California at San Francisco, San Francisco, CA 94121, USA
    Front Biosci 12:4986-96. 2007
    ..This study also highlights distinct merits of intranasal drug delivery for treating CNS diseases...
  64. ncbi Intranasal administration of peptide antigens of HIV with mucosal adjuvant CpG ODN coentrapped in microparticles enhances the mucosal and systemic immune responses
    Par Bahadur Pun
    Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India
    Int Immunopharmacol 9:468-77. 2009
    ..Thus the overall study highlighted the importance of CpG ODNs as a mucosal adjuvant for weaker peptide antigens and thus can explore for developing peptide based vaccine against HIV...
  65. ncbi Coadministration of antigen and particles optimally stimulates the immune response in an intranasal administration model in mice
    M van Zijverden
    TNO Nutrition and Food Research, Zeist, The Netherlands
    Toxicol Appl Pharmacol 177:174-8. 2001
  66. pmc Intranasal administration of a meningococcal outer membrane vesicle vaccine induces persistent local mucosal antibodies and serum antibodies with strong bactericidal activity in humans
    B Haneberg
    Department of Vaccinology, National Institute of Public Health, Oslo, Norway
    Infect Immun 66:1334-41. 1998
  67. pmc Influenza vaccine effectiveness among US military basic trainees, 2005-06 season
    Jennifer K Strickler
    Naval Health Research Center, San Diego, California 92186 5122, USA
    Emerg Infect Dis 13:617-9. 2007
    ..Vaccine effectiveness against laboratory-confirmed influenza was 92% (95% confidence interval 85%-96%)...
  68. pmc Intranasal insulin administration dose-dependently modulates verbal memory and plasma amyloid-beta in memory-impaired older adults
    Mark A Reger
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    J Alzheimers Dis 13:323-31. 2008
    ..These findings suggest that groups with different genetic risks for AD may show differential dose-response curves following intranasal insulin administration...
  69. ncbi Intranasal immunization with formalin-inactivated virus vaccine induces a broad spectrum of heterosubtypic immunity against influenza A virus infection in mice
    Ayato Takada
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, 108 8639, Japan
    Vaccine 21:3212-8. 2003
    ..This approach may overcome limitations in the efficacy of inactivated influenza vaccines and confer potent immunity to humans against viruses with new pandemic potential...
  70. ncbi Intranasal administration of mouse [D-Leu-4]OB3, a synthetic peptide amide with leptin-like activity, enhances total uptake and bioavailability in Swiss Webster mice when compared to intraperitoneal, subcutaneous, and intramuscular delivery systems
    Zachary M Novakovic
    Department of Medicine, Division of Endocrinology and Metabolism, MC141, Albany Medical College, Albany, NY, 12208, USA
    Regul Pept 154:107-11. 2009 male Swiss Webster mice following ip, subcutaneous (sc), and intramuscular (im) injection, and after intranasal administration with Intravail, a new class of patented transmucosal delivery enhancement agents...
  71. ncbi Microdialysis evaluation of the brain distribution of stavudine following intranasal and intravenous administration to rats
    Zheng Yang
    Department of Pharmaceutics, University of Minnesota, 308 Harvard St SE, Minneapolis, MN 55455, USA
    J Pharm Sci 94:1577-88. 2005
  72. ncbi Productive infection in the murine central nervous system with avian influenza virus A (H5N1) after intranasal inoculation
    Takuya Iwasaki
    Department of Pathology, National Institute of Infectious Diseases, Toyama 1 23 1, Shinjuku ku, 162 8640 Tokyo, Japan
    Acta Neuropathol 108:485-92. 2004
    ..Neurons were frequently infected and glial and ependymal cells were also infected. Transneuronal transmission of the virus might play the important role of viral spread within the CNS...
  73. pmc Chronic intranasal administration of mould spores or extracts to unsensitized mice leads to lung allergic inflammation, hyper-reactivity and remodelling
    Olivier Denis
    Allergology Unit, WIV Pasteur Institute of Brussels, Brussels, Belgium
    Immunology 122:268-78. 2007
    ..Here we report on the effect of chronic intranasal administration of C. herbarum spores or A. alternata extracts to unsensitized BALB/c mice...
  74. pmc The protective efficacy of chlamydial protease-like activity factor vaccination is dependent upon CD4+ T cells
    Cathi Murphey
    Department of Biology, University of Texas at San Antonio, San Antonio, TX 78249, USA
    Cell Immunol 242:110-7. 2006
    ..Moreover, anti-chlamydial immunity could be adoptively transferred to naïve recipients using CPAF-specific CD4(+) T cells. Therefore, CPAF mediated anti-chlamydial immunity is highly dependent upon antigen-specific CD4(+) T cells...
  75. ncbi Intranasal administration of proteoliposome-derived cochleates from Vibrio cholerae O1 induce mucosal and systemic immune responses in mice
    Reinaldo Acevedo
    Immunology Department, Bacterial Vaccines Division of Finlay Institute, Havana, Cuba
    Methods 49:309-15. 2009
    ..These results show for the first time that AFCo2 can be obtained from V. cholerae O1 proteoliposomes and have the potential to protect against the pathogen when administered intranasally...
  76. ncbi Tissue distribution of radioactivity following intranasal administration of radioactive microspheres
    J E Eyles
    Pharmaceutical Sciences, Life and Health Sciences, Aston University, Birmingham, UK
    J Pharm Pharmacol 53:601-7. 2001
    ..This effect may contribute to the effectiveness of pulmonary delivered antigen-loaded microparticles as humoral immunogens...
  77. pmc A new minimal-stress freely-moving rat model for preclinical studies on intranasal administration of CNS drugs
    Jasper Stevens
    Division of Pharmacology, LACDR Leiden University, Leiden, The Netherlands
    Pharm Res 26:1911-7. 2009
    To develop a new minimal-stress model for intranasal administration in freely moving rats and to evaluate in this model the brain distribution of acetaminophen following intranasal versus intravenous administration.
  78. pmc Intranasal administration of the growth-compromised HSV-2 vector DeltaRR prevents kainate-induced seizures and neuronal loss in rats and mice
    Jennifer M Laing
    Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, 655 W Baltimore Street, Baltimore, MD 21201 1559, USA
    Mol Ther 13:870-81. 2006
    ..Intranasally delivered DeltaRR prevents kainic acid-induced seizures, neuronal loss, and inflammation, in both rats and mice. The data suggest that DeltaRR is a promising therapeutic platform for neurodegenerative diseases...
  79. ncbi Murine host responses to respiratory syncytial virus (RSV) following intranasal administration of a Protollin-adjuvanted, epitope-enhanced recombinant G protein vaccine
    Yan Huang
    Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada
    J Clin Virol 44:287-91. 2009
    ..We hypothesize that the performance of this "epitope enhanced" recombinant G protein fragment may be further improved by combining with the newly developed adjuvant, Protollin, coupled with intranasal delivery...
  80. ncbi Drug brain distribution following intranasal administration of Huperzine A in situ gel in rats
    Yan Zhao
    Shanghai Institute of Pharmaceutical Industry, Shanghai 200040, China
    Acta Pharmacol Sin 28:273-8. 2007
    To determine the uptake extent of Huperzine A (Hup A) into the brain after intranasal administration of Hup A in situ gel to rats, and to compare the pharmacokinetic parameters between intranasal administration and iv and po.
  81. pmc Intranasal insulin ameliorates experimental diabetic neuropathy
    George Francis
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Diabetes 58:934-45. 2009
  82. ncbi P-Glycoprotein attenuates brain uptake of substrates after nasal instillation
    Candace L Graff
    Division of Drug Delivery and Disposition, School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599 7360, USA
    Pharm Res 20:1225-30. 2003
    ..These experiments were conducted to elucidate the role of the blood-brain barrier efflux transporter P-glycoprotein (P-gp) in attenuating delivery of P-gp substrates to the brain after nasal administration in mice...
  83. ncbi Mechanisms of broad cross-protection provided by influenza virus infection and their application to vaccines
    Shin ichi Tamura
    Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
    Jpn J Infect Dis 58:195-207. 2005
    ..In the near future, some of these trials may provide new, safer and more effective broad-spectrum vaccines than those currently available...
  84. ncbi Mucosal delivery of a respiratory syncytial virus CTL peptide with enterotoxin-based adjuvants elicits protective, immunopathogenic, and immunoregulatory antiviral CD8+ T cell responses
    C P Simmons
    Department of Biochemistry, Imperial College of Science, Technology and Medicine, South Kensington, London, United Kingdom
    J Immunol 166:1106-13. 2001
    ..These studies emphasize that protective and immunoregulatory CD8(+) CTL responses can be mucosally elicited using enterotoxin-based mucosal adjuvants but that resistance against viral infection may be accompanied by enhanced disease...
  85. ncbi Correlates of immune protection induced by live, attenuated, cold-adapted, trivalent, intranasal influenza virus vaccine
    R B Belshe
    Department of Medicine, Saint Louis University, St Louis, MO 63110, USA
    J Infect Dis 181:1133-7. 2000
    ..Any serum HAI antibody or any nasal wash IgA antibody was correlated with significant protection from H1N1 infection as indicated by vaccine-virus shedding, and high efficacy against H1N1 challenge was demonstrated...
  86. ncbi Intranasal administration of a live non-pathogenic avian H5N1 influenza virus from a virus library confers protective immunity against H5N1 highly pathogenic avian influenza virus infection in mice: comparison of formulations and administration routes of
    Yoshitaka Kashima
    Department of Pathology, Shiga University of Medical Science, 485 Setatsukinowa, Otsu, Shiga 520 2192, Japan
    Vaccine 27:7402-8. 2009
    ..In the present study, we found that intranasal administration of a live H5N1 subtype non-pathogenic virus induced antibody and cytotoxic T lymphocyte responses and ..
  87. ncbi Delivery of 125I-cobrotoxin after intranasal administration to the brain: a microdialysis study in freely moving rats
    Fanzhu Li
    Department of Pharmaceutics, Zhejiang Chinese Medical University, Hangzhou 310053, PR China
    Int J Pharm 328:161-7. 2007
    ..v. administration. Additionally, multi-probe microdialysis technique should be considerably valuable in brain delivery studies...
  88. ncbi Intranasal administration of midazolam: pharmacokinetic and pharmacodynamic properties and sedative potential
    O Fukuta
    Department of Pediatric Dentistry, School of Dentistry, Aichi Gakuin University, Nagoya, Japan
    ASDC J Dent Child 64:89-98. 1997
    ..male volunteers to study plasma level changes, sedative effects and variations in vital signs following intranasal administration of 0.2 mg/kg and 0.3 mg/kg doses of midazolam. Eight subjects received 0...
  89. ncbi Nasal insulin delivery in the chitosan solution: in vitro and in vivo studies
    Shaoyun Yu
    Department of Pharmaceutics, Health Science Center, Peking University, Beijing 100083, PR China
    Int J Pharm 281:11-23. 2004
    ..The results of in vitro experiments were in good agreement with that of in vivo studies...
  90. pmc Antibody responses in the lower respiratory tract and male urogenital tract in humans after nasal and oral vaccination with cholera toxin B subunit
    A Rudin
    Department of Medical Microbiology and Immunology and Department of Respiratory Medicine, Goteborg University, S 413 46 Goteborg, Sweden
    Infect Immun 67:2884-90. 1999
  91. ncbi Intranasal administration of a proteosome-influenza vaccine is well-tolerated and induces serum and nasal secretion influenza antibodies in healthy human subjects
    John Treanor
    Infectious Diseases Unit, University of Rochester School of Medicine, 601 Elmwood Avenue, Room 3 6308, Rochester, NY 14642 0001, USA
    Vaccine 24:254-62. 2006
    ..Further evaluation of mucosal influenza immunization using the proteosome adjuvant/delivery system is clearly warranted...
  92. ncbi IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger
    Stephane Ferretti
    Novartis Respiratory Research Center, Wimblehurst Road, RH12 5 AB Horsham, UK
    J Immunol 170:2106-12. 2003
    ..In addition, our results suggest that IL-15 could represent a physiological trigger that leads to IL-17 production following bacterial infection...
  93. ncbi Immunogenicity of bovine parainfluenza type 3 virus proteins encapsulated in nanoparticle vaccines, following intranasal administration to mice
    Martin J Shephard
    School of Pharmacy, Medical Biology Centre, The Queen s University of Belfast, 97 Lisburn Road, UK
    Res Vet Sci 74:187-90. 2003
    ..Immunoblotting using serum from the vaccinated mice, demonstrated strong reactions against the major BPI-3 proteins...
  94. ncbi Effect of lipopolysaccharide on intranasal administration of liposomal Newcastle disease virus vaccine to SPF chickens
    Li Ping Tseng
    Graduate Institute of Biomedical Engineering, College of Engineering, College of Medicine, National Taiwan University, Taiwan, Republic of China
    Vet Immunol Immunopathol 131:285-9. 2009
    ..The results suggest that PC-Lip or PS-Lip might thus be suitable as a potential adjuvant for mucosal vaccination against NDV in chickens...
  95. ncbi A dilemma for mucosal vaccination: efficacy versus toxicity using enterotoxin-based adjuvants
    Kohtaro Fujihashi
    Department of Microbiology, BBRB Room 716, Immunobiology Vaccine Center, University of Alabama at Birmingham, Medical Center, 35294 2170, USA
    Vaccine 20:2431-8. 2002
    ..When mucosal adjuvanticity of CT was evaluated in aged mice, an early immune dysregulation was evident in the mucosal immune system. The present review discusses these potential problems for effective mucosal vaccine development...
  96. ncbi Enhancement of acute phase and inhibition of chronic phase of experimental autoimmune neuritis in Lewis rats by intranasal administration of recombinant mouse interleukin 17: potential immunoregulatory role
    S H Pelidou
    Division of Geriatric Medicine, Huddinge University Hospital, Stockholm, S 141 86, Sweden
    Exp Neurol 163:165-72. 2000
    ..The results indicate that IL-17 plays an immunoregulatory role in chronic EAN which could have implications for immunomodulatory treatments of chronic autoimmune disease of the PNS...
  97. ncbi The universal influenza vaccine M2e-HBc administered intranasally in combination with the adjuvant CTA1-DD provides complete protection
    Marina De Filette
    DMBR, Ghent University VIB, FSVM Building, Technologiepark 927, B 9052 Ghent Zwijnaarde, Belgium
    Vaccine 24:544-51. 2006
    ..When the vaccine was administered intraperitoneally, the adjuvant improved the M2e antibody titer in circulation, but did not significantly reduce the morbidity...
  98. ncbi In vivo induction of mucosal immune responses by intranasal administration of chitosan microspheres containing Bordetella bronchiseptica DNT
    Mi Lan Kang
    Department of Infectious Diseases, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea
    Eur J Pharm Biopharm 63:215-20. 2006
    ..7). Based on the report, in vivo activity of immune-induction was investigated by intranasal administration of the BBD-loaded CMs into mice...
  99. ncbi Intranasal administration of CpG DNA lipoplex prevents pulmonary metastasis in mice
    Shuwen Zhou
    Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Cancer Lett 287:75-81. 2010
    ..cationic liposomes to complex with CpG DNA (CpG DNA lipoplex) to prevent pulmonary metastasis following intranasal administration in mice...
  100. pmc Preferential brain homing following intranasal administration of Trypanosoma cruzi
    Kacey Caradonna
    Parasitology Research Center, Department of Pathology, Tufts University School of Medicine, 150 Harrison Avenue, Boston, MA 02111, USA
    Infect Immun 77:1349-56. 2009
    ..The model may facilitate studies designed to understand mechanisms underlying T. cruzi infection of the central nervous system...
  101. ncbi Intranasal administration of drugs
    Mandy Scheibe
    Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, Fetscherstrasse 74, 01307 Dresden, Germany
    Arch Otolaryngol Head Neck Surg 134:643-6. 2008
    ..To investigate how nasally applied substances distribute in the nose depending on the form of application...

Research Grants65

  1. Recombinant Sendai Virus as a Novel HIV Vaccine Vector
    KAREN SLOBOD; Fiscal Year: 2004
    ..We further suggest that intranasal administration of SV-based vaccines will prove to be a facile and effective means of priming systemic and mucosal ..
  2. Effect of PPARy Ligands on Alcohol-Induced Alveolar Macrophage Oxidative Stress
    Samantha M Yeligar; Fiscal Year: 2013 vivo, b) methods to directly deliver PPAR? ligand therapeutics to the lungs of mouse models using intranasal administration, and c) skills required to develop and manage colonies of knockout and transgenic mice...
  3. Intranasal CNS delivery of drugs against organophosphorous threat agents
    ..Our central hypothesis is that intranasal administration of therapeutic formulations of oxime, atropine and midazolam in a nanoemulsion form can rapidly deliver ..
  4. Regulation of IL4 signal transduciton by poly (ADP-ribose) polymerase-1.
    Rahul Datta; Fiscal Year: 2011
    ..b>Intranasal administration of IL-4 fails to restore eosinophilia to PARP-1 knockout mice, but administration of IL-5 does restore ..
    Devendra K Agrawal; Fiscal Year: 2012
    ..We have discovered that intranasal administration of ClC3 siRNA prevented airway hyperresponsiveness to methacholine, BALF eosinophilia and airway ..
  6. Enhancing NEAT to Treat Obesity
    Catherine M Kotz; Fiscal Year: 2012
    ..NEAT;2) viral- mediated overexpression of orexin receptor(s) in obese rodents will reduce body weight;3) intranasal administration of orexin A, by enhancing orexin levels in brains of rat, will produce enhancement of NEAT...
  7. A Novel Approach for Mycobacterium Tuberculosis Vaccine Development
    Biao He; Fiscal Year: 2013
    ..Finally, the intranasal administration of PIV5 is a very good feature for eliciting robust mucosal immune responses, and thus ideal for ..
  8. Crystalline hydroxocobalamin and methemoglobin as a treatment of H2S intoxication
    PHILIPPE A HAOUZI; Fiscal Year: 2013
    ..the dose used for cyanide intoxication makes it possible to deliver this agent using intramuscular or intranasal administration. Since we have demonstrated that H2S produces in small animals (rodents) a specific protective response, ..
  9. Development of novel vaccines against drug abuse - Proof of concept study for vac
    CHENMING M ZHANG; Fiscal Year: 2012
    ..the size of the vaccine, which will possess unparalleled stability and could be suitable for oral or intranasal administration. This proof- of-concept project is focused on developing the particle assembly process and test the ..
  10. Oxytocin Receptors and Social Behavior
    Larry J Young; Fiscal Year: 2013
    ..b>Intranasal administration of OT in humans increases attention to social cues, gazing into the eyes, inferring the emotions of ..
  11. Neurovascular Protection for Early Brain Injury after SAH
    John H Zhang; Fiscal Year: 2013
    ..Our central hypothesis is that intranasal administration of rOPN provides protection against early brain injury after SAH by reducing neuronal apoptosis and ..
    SATHYANARAYANA N MURTHY; Fiscal Year: 2013
    ..We hypothesize that ziconotide could be delivered to CSF via intranasal administration and the use of appropriate barrier modulating agents would significantly improve its bioavailability to ..
  13. Live Attenuated Recombinant Bacterial Delivery of Polysaccharide Vaccine Antigens
    Joanna B Goldberg; Fiscal Year: 2010
    ..aeruginosa pneumonia in a mouse model system and found that intranasal administration of the vaccine provides better protection than either oral or intraperitoneal delivery...
  14. TYPE II Enterotoxins as Mucosal Immunomodulators
    Terry D Connell; Fiscal Year: 2011
    ..Upon intranasal administration, LT-IIb exerts immunostimulatory effects using immune pathways and cellular receptors different from ..
  15. Development of a Mouse Trigeminal Pain Model
    ANDREW RUSSO; Fiscal Year: 2009
    ..We will use intranasal administration to target the trigeminal nerve, which innervates the nasal mucosa...
  16. PARP activity in allergic inflammation
    Mark H Kaplan; Fiscal Year: 2012
    ..Our preliminary data also demonstrates that the intranasal administration of a PARP inhibitor to a mouse model of asthma reduces inflammation in the lung...
  17. H5N1 Influenza Virus as a Novel Etiological Agent in Parkinsons Disease
    Richard J Smeyne; Fiscal Year: 2010
    ..detection of H5N1 virus to map the presence of H5N1 at 1, 3, 7, 10, 21, 28, 60 and 90 days following intranasal administration of H5N1...
  18. Therapeutic Efficacy of Intranasal WGA-GLP1 in AD
    Neelima B Chauhan; Fiscal Year: 2013
    ..We have already tested the feasibility of intranasal administration of WGA- labeled GLP1 (WGA-GLP1) to the brain in 5XFAD mice modeling AD, which strengthens successful ..
  19. Exploring sex differences in the neural correlates of PTSD: Impact of oxytocin
    ..Oxytocin (OT) is a neuropeptide that promotes social bonding, trust and calmness. Intranasal administration of OT reduces amygdala responding to fearful faces...
  20. CysLT and P2Y Receptors in Lung Inflammation
    Joshua A Boyce; Fiscal Year: 2013
    ..demonstrate that P2Y6 receptors are major negative regulators of pulmonary inflammation induced by the intranasal administration of an extract (Df) from the HDM Dermatophagoides farinae...
  21. RTB-mediated delivery: Orchestrating antigen trafficking to enhance cell immunity
    Carole L Cramer; Fiscal Year: 2013
    ..of the recombinant products, and 3) assessment of elicited immune responses in mice following intranasal administration of control, NP:RTB, and NP:RTBER immunogen formulations...
  22. Evaluation and Production of a Multivalent Adenoviral Plague Vaccine
    ERIC ROTHE; Fiscal Year: 2013
    ..The project will test the hypothesis that a single, intranasal administration of the adenoviral vaccine can elicit a strong protective immune response in non-human primates (NHPs) ..
  23. Nasocerebral administration of peptides for temporomandibular joint pain
    LAWRENCE ROBERT TOLL; Fiscal Year: 2010
    ..The delivery pathway involves the intranasal administration of FDA approved analgesic peptides that are then transported directly to trigeminal pain targets, thus ..
  24. Oxytocin Treatment of Social Cognitive and Functional Deficits in Schizophrenia
    David Lewis Penn; Fiscal Year: 2013
    ..OT also exerts antipsychotic-like efficacy in animal models of schizophrenia. In recent human studies, intranasal administration of OT increased interpersonal trust and eye contact as well as improved emotion recognition and theory ..
  25. A Therapeutic Agent for Radiation-induced Lung Fibrosis
    SHUAN HUANG; Fiscal Year: 2009
    ..b>Intranasal administration of this PEG-TGF-( peptantagonist effectively prevents bleomycin-induced lung fibrosis in mice and ..
  26. Intranasal Delivery of Peptide Drugs to the Brain
    Nazneen N Dewji; Fiscal Year: 2012
    ..In this application we propose to explore the delivery of P8 to the mouse brain by intranasal administration. PUBLIC HEALTH RELEVANCE: Alzheimer's disease is a devastating degenerative neurological disorder ..
  27. Intranasal nociceptin for the treatment of migraine and head pain
    JORDAN MECHANIC; Fiscal Year: 2009
    ..To this end, we funded a phase 2 clinical trial to examine the efficacy of intranasal administration of the peptide oxytocin for treatment of migraine...
  28. Chlipoplex Nanoparticle Prophylactics for RSV Infection
    Shyam Mohapatra; Fiscal Year: 2004
    ..of prophylaxis for respiratory syncytial virus (RSV) infection and other respiratory viruses using intranasal administration of chitosan nanoparticles containing pDNA, which allows de novo expression of IFNs...
  29. Recombinant hPIV3 and RSV Sendai Virus Vaccine Phase I Clinical Trial Development
    JERRY SHENEP; Fiscal Year: 2009
    ..This preclinical data combined with our previous demonstration that intranasal administration of live, unmodified Sendai virus is safe in adults and preliminarily in young children makes a ..
  30. Augmenting innate and vaccine immune response with der-G
    Daniel Zimmerman; Fiscal Year: 2003
    ..Thus, these studies will deliver derG and the vaccine by intranasal administration and will monitor both systemic and mucosal (pulmonary) immunity...
  31. Vaccine and Magnetic Resonance Imaging Approaches for AD
    Martin Sadowski; Fiscal Year: 2003
    ..An alternative way of triggering immune response, which we will also test in this project will be intranasal administration of antigen...
    H H Chow; Fiscal Year: 2000
  33. Nanoparticle-based vaccines against flaviviruses
    Michel Ledizet; Fiscal Year: 2009
    ..Second, vaccination can occur with a needle-free procedure (oral or intranasal administration)...
  34. Development of ColdSol TMfor Rhinovirus Infections
    CATHERINE CHARLES; Fiscal Year: 2003
    ..A human clinical trial using intranasal administration of an anti-ICAM whole antibody delayed the onset of colds by up to 2 days and decreased symptoms 50% but ..
    DENNIS METZGER; Fiscal Year: 2001
    The purpose of this study is to determine whether intranasal administration of interleukin-12 (IL-12) will shift lung cytokine and antibody expression during immune responses and enhance the effectiveness of vaccination against ..
  36. Adenovirus-vectored nasal anthrax vaccine
    DE CHU TANG; Fiscal Year: 2005
    ..potency of an Ad vector encoding PA83 will be compared to that of a codon-optimized counterpart after intranasal administration into mice and rabbits...
  37. Tetravalent Humanized Anti-ICAM for Rhinovirus Infection
    Fang Fang; Fiscal Year: 2001
    ..A human clinical trial using intranasal administration of an anti-ICAM-1 whole antibody delayed the onset of colds by up to 2 days and decreased symptoms 50 ..
  38. Novel MEMS and Microfluidic Platforms for Drug Delivery
    RONALD SIEGEL; Fiscal Year: 2004
    ..These solutions are expected to remain stable long enough to be absorbed rapidly upon intranasal administration. The present work will test the hypothesis that the microfabicated mixer produces solutions of diazepam ..
    Peter Hobart; Fiscal Year: 2000
    ..Naked" plasmid DNAs, encoding these antigens, will be used to vaccinate animals. Intramuscular and intranasal administration of DNA will be tested and compared based on the ability to generate humoral and/or cell-based immunity...
  40. Immunological control of a persistent viral infection
    Sally Sarawar; Fiscal Year: 2002
    ..MHV-68 replicates in the lungs of mice following intranasal administration and establishes a latent infection in B cells and epithelia...
  41. Innate Immune Stimulation as a Pathogen Countermeasure
    Jeff Fairman; Fiscal Year: 2007
    ..Complete protection has also been observed following intraperitoneal and intranasal administration of CLDC 48 hours prior to lethal intranasal challenge with Francisella tularensis LVS...
  42. Osteopontin, a novel neuroprotectant in brain ischemia
    Mary Stenzel Poore; Fiscal Year: 2006
    ..Finally, we seek to develop a new delivery strategy for OPN using intranasal administration to improve delivery to the brain. The aims are: Aim 1...
  43. Affect, Context, and Placebo Responses to Nicotine
    Kenneth Perkins; Fiscal Year: 2005
    ..Secondary analyses may identify important individual characteristics associated with placebo responses, aiding in the prediction of which smokers ultimately are likely to benefit most from manipulation of placebo effects. ..
    Kenneth Perkins; Fiscal Year: 2001
    Kenneth Perkins; Fiscal Year: 2003
    ..e., in nicotine-naive individuals). Results will provide directions for future research on vulnerability to tobacco dependence and for targeted efforts to prevent smoking onset. ..
  46. Tobacco Smoking, Nicotine and Negative Affect Relief
    Kenneth Perkins; Fiscal Year: 2009
    ..In sum, this research will help address the fundamental question of why cigarette smoking is reinforcing. ..
    Kenneth Perkins; Fiscal Year: 2003
  48. Nasal Delivery of Naltrexone for Treatment of Alcoholism
    Daniel Wermeling; Fiscal Year: 2006
    ..The long-term goal of this work is to develop and commercialize nasal delivered NTX for the treatment of alcoholism. [unreadable] [unreadable] [unreadable]..
  49. PTS1 Regulation of Brain Met Enk Levels in Alcoholism
    William Banks; Fiscal Year: 2004
    ..abstract_text> ..
    Noel Childers; Fiscal Year: 2001
  51. Mechanisms of HIV Transport Across the BBB
    William Banks; Fiscal Year: 2004
  52. Prion Transport Across the Blood-Brain Barrier
    William Banks; Fiscal Year: 2009
    ..To cause disease, prions must cross the blood-brain barrier to enter the brain. We will determine how prions cross the BBB. Knowing how prions enter the brain should lead to strategies on how to prevent prion diseases. ..
  53. Opiate Addiction and HIV-1 Induced Release of Cytokines
    William Banks; Fiscal Year: 2006
  54. Pertussis Toxin Trafficking and Processing in Cells
    NICHOLAS CARBONETTI; Fiscal Year: 2005
    ..Therefore the specific aims of this proposal are to investigate the trafficking, processing and transcytosis of PT in mammalian cells and the key features of this toxin that mediate these events. ..
    David Briles; Fiscal Year: 2008
    ..The MCBP advisory committee will advise the trainees in their research and training programs and in their search for a job or postdoctoral position at the completion of their MCBP training. [unreadable] [unreadable]..
    Fuad Baroody; Fiscal Year: 2003
    ..This will hopefully help to improve our therapeutic modalities for this enigmatic illness that affects millions of Americans every year. ..
  57. Role of Pertussis Toxin in Bordetella pertussis infection
    Nicholas H Carbonetti; Fiscal Year: 2010
    ..pertussis infection will increase our understanding of the pathogenic mechanisms of this organism, and may lead to novel therapeutic approaches to combat pertussis infection and disease. ..
    PEDRO PIEDRA; Fiscal Year: 2007
    ..abstract_text> ..
  59. Effect of Pertussis Toxin on Cough in Guinea Pig
    NICHOLAS CARBONETTI; Fiscal Year: 2005
    ..abstract_text> ..
  60. Alphavirus Replicons for Mucosal HIV Vaccines
    Michael Vajdy; Fiscal Year: 2002
    Sandra Comer; Fiscal Year: 2002
    ..In addition, they will more carefully examine sex differences in analgesic response to butorphanol and morphine, two agonists with differing selectivities for mu and kappa opioid receptors. ..
  62. Sphingolipid signaling in olfactory mucosa
    Mary Beth Genter; Fiscal Year: 2004
    ..abstract_text> ..
  63. Role of DAP12 in type 1 anti-mycobacterial immunity
    Zhou Xing; Fiscal Year: 2005
    ..We strongly believe that our studies will provide new insights into the mechanisms of type 1 anti-microbial immunity and novel targets for immune modulation. ..