intradermal injections

Summary

Summary: The forcing into the skin of liquid medication, nutrient, or other fluid through a hollow needle, piercing the top skin layer.

Top Publications

  1. ncbi Influence of routes and administration parameters on antibody response of pigs following DNA vaccination
    Annette Malene Barfoed
    Laboratory of Virology and Immunology, Department of Veterinary Microbiology, The Royal Veterinary and Agricultural University, Stigbøjlen 7, DK 1870 Frederiksberg C, Denmark
    Vaccine 22:1395-405. 2004
  2. ncbi Sympathetic modulation of activity in Adelta- and C-primary nociceptive afferents after intradermal injection of capsaicin in rats
    Yong Ren
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1069, USA
    J Neurophysiol 93:365-77. 2005
  3. ncbi Evaluation of SIV-lipopeptide immunizations administered by the intradermal route in their ability to induce antigen specific T-cell responses in rhesus macaques
    Zoe Coutsinos
    Institut Cochin, Department d Immunologie, INSERM U567, CNRS UMR 8104, IFR Alfred Jost, Universite Rene Descartes, 27 rue du Faubourg Saint Jacques, 75014 Paris, France
    FEMS Immunol Med Microbiol 43:357-66. 2005
  4. ncbi Treatment of facial lipoatrophy with intradermal injections of polylactic acid in HIV-infected patients
    Matthieu Lafaurie
    Service des Maladies Infectieuses et Tropicales, Hopital Saint Louis, Paris, France
    J Acquir Immune Defic Syndr 38:393-8. 2005
  5. ncbi Intradermal/subcutaneous immunization by electroporation improves plasmid vaccine delivery and potency in pigs and rhesus macaques
    Lauren A Hirao
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 422 Curie Boulevard, 505 SCL, Philadelphia, PA 19104, USA
    Vaccine 26:440-8. 2008
  6. ncbi Biodegradable polymer microneedles: fabrication, mechanics and transdermal drug delivery
    Jung Hwan Park
    The Wallace H Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Georgia Institute of Technology, Atlanta, GA 30332, USA
    J Control Release 104:51-66. 2005
  7. ncbi Failure of multiple-site intradermal postexposure rabies vaccination in patients with human immunodeficiency virus with low CD4+ T lymphocyte counts
    T Tantawichien
    Queen Saovabha Memorial Institute, Thai Red Cross Society, and Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    Clin Infect Dis 33:E122-4. 2001
  8. ncbi Intradermal injections: traditional bevel up versus bevel down
    Karen Tarnow
    The University of Kansas School of Nursing, Kansas City 66160, USA
    Appl Nurs Res 17:275-82. 2004
  9. ncbi Side-effects of intradermal injections of botulinum A toxin in the treatment of palmar hyperhidrosis: a neurophysiological study
    C Swartling
    Institution of Medical Science, Dermato Venereology, Department of Dermatology, Uppsala University, 751 85 Uppsala, Sweden
    Eur J Neurol 8:451-6. 2001
  10. ncbi The challenge to provide affordable rabies post-exposure treatment
    Mary J Warrell
    Centre for Tropical Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
    Vaccine 21:706-9. 2003

Detail Information

Publications198 found, 100 shown here

  1. ncbi Influence of routes and administration parameters on antibody response of pigs following DNA vaccination
    Annette Malene Barfoed
    Laboratory of Virology and Immunology, Department of Veterinary Microbiology, The Royal Veterinary and Agricultural University, Stigbøjlen 7, DK 1870 Frederiksberg C, Denmark
    Vaccine 22:1395-405. 2004
    ..m.)/intradermal (i.d.) injection of plasmid DNA. This indicates, that the ear is an attractive site for gene gun vaccination of pigs...
  2. ncbi Sympathetic modulation of activity in Adelta- and C-primary nociceptive afferents after intradermal injection of capsaicin in rats
    Yong Ren
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1069, USA
    J Neurophysiol 93:365-77. 2005
    ....
  3. ncbi Evaluation of SIV-lipopeptide immunizations administered by the intradermal route in their ability to induce antigen specific T-cell responses in rhesus macaques
    Zoe Coutsinos
    Institut Cochin, Department d Immunologie, INSERM U567, CNRS UMR 8104, IFR Alfred Jost, Universite Rene Descartes, 27 rue du Faubourg Saint Jacques, 75014 Paris, France
    FEMS Immunol Med Microbiol 43:357-66. 2005
    ..Given the crucial role of CD8+ T-lymphocytes in HIV/SIV containment, vaccination through the intradermal route should merit high consideration in the development of an AIDS vaccine...
  4. ncbi Treatment of facial lipoatrophy with intradermal injections of polylactic acid in HIV-infected patients
    Matthieu Lafaurie
    Service des Maladies Infectieuses et Tropicales, Hopital Saint Louis, Paris, France
    J Acquir Immune Defic Syndr 38:393-8. 2005
    This study assessed the safety and efficacy of intradermal injections of polylactic acid (PLA) in patients with facial lipoatrophy under antiretroviral therapy.
  5. ncbi Intradermal/subcutaneous immunization by electroporation improves plasmid vaccine delivery and potency in pigs and rhesus macaques
    Lauren A Hirao
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 422 Curie Boulevard, 505 SCL, Philadelphia, PA 19104, USA
    Vaccine 26:440-8. 2008
    ..The induced responses were TH1 mediated. These results support that skin electroporation may have importance as an immunization approach in larger animal models...
  6. ncbi Biodegradable polymer microneedles: fabrication, mechanics and transdermal drug delivery
    Jung Hwan Park
    The Wallace H Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Georgia Institute of Technology, Atlanta, GA 30332, USA
    J Control Release 104:51-66. 2005
    ..Altogether, these results indicate that biodegradable polymer microneedles can be fabricated with an appropriate geometry and sufficient strength to insert into skin, and thereby dramatically increase transdermal transport of molecules...
  7. ncbi Failure of multiple-site intradermal postexposure rabies vaccination in patients with human immunodeficiency virus with low CD4+ T lymphocyte counts
    T Tantawichien
    Queen Saovabha Memorial Institute, Thai Red Cross Society, and Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    Clin Infect Dis 33:E122-4. 2001
    ....
  8. ncbi Intradermal injections: traditional bevel up versus bevel down
    Karen Tarnow
    The University of Kansas School of Nursing, Kansas City 66160, USA
    Appl Nurs Res 17:275-82. 2004
    ..Subjects rated the first injection better (p < 0.05) with no preference regarding technique. Subjects administering injections reported bevel up more comfortable (p < 0.01). Bevel up was significantly faster...
  9. ncbi Side-effects of intradermal injections of botulinum A toxin in the treatment of palmar hyperhidrosis: a neurophysiological study
    C Swartling
    Institution of Medical Science, Dermato Venereology, Department of Dermatology, Uppsala University, 751 85 Uppsala, Sweden
    Eur J Neurol 8:451-6. 2001
    Focal palmar hyperhidrosis can be effectively abolished by intradermal injections with botulinum toxin. Muscle weakness of finger grip has been reported as a reversible side-effect of this new treatment...
  10. ncbi The challenge to provide affordable rabies post-exposure treatment
    Mary J Warrell
    Centre for Tropical Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
    Vaccine 21:706-9. 2003
    ..using an ID regimen with a large dose of vaccine on the first day of treatment especially when no RIG is available; and (iv). promoting pre-exposure prophylaxis to eliminate the need for RIG and provide better rabies prophylaxis...
  11. ncbi Intradermal vaccine delivery: will new delivery systems transform vaccine administration?
    Paul Henri Lambert
    CMU, Centre of Vaccinology, Geneva 4, Switzerland
    Vaccine 26:3197-208. 2008
    ..New delivery systems currently in development facilitate convenient intradermal vaccination, unlocking the potential advantages of this delivery route, and potentially transforming vaccine delivery...
  12. ncbi The safety and efficacy of dose-sparing intradermal administration of influenza vaccine in human immunodeficiency virus-positive patients
    Homayoon Khanlou
    Arch Intern Med 166:1417. 2006
  13. pmc Evidence for a role of osteopontin in macrophage infiltration in response to pathological stimuli in vivo
    C M Giachelli
    Department of Pathology, University of Washington, Seattle 98195, USA
    Am J Pathol 152:353-8. 1998
    ..These data support the hypothesis that osteopontin may be a critical mediator of inflammation in specific disease and injury states, potentially by promoting macrophage adhesion and migration...
  14. ncbi Seasonal influenza vaccine delivered by intradermal microinjection: A randomised controlled safety and immunogenicity trial in adults
    Isabel Leroux-Roels
    Center for Vaccinology, Ghent University and Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    Vaccine 26:6614-9. 2008
    ..Intradermal TIV induced non-inferior humoral immune responses against all three strains and superior responses against both A strains (H1N1, H3N2) compared with the control. Both vaccines were well tolerated...
  15. ncbi Safety and efficacy of a novel microneedle device for dose sparing intradermal influenza vaccination in healthy adults
    Pierre Van Damme
    Centre for the Evaluation of Vaccination, Vaccine and Infectious Disease Institute, University of Antwerp, Belgium
    Vaccine 27:454-9. 2009
    ..Intradermal vaccine delivery has been shown to induce good immune responses with low vaccine doses. Technologies for drug-delivery which specifically target the skin may render intradermal vaccination more accessible...
  16. pmc Intradermal influenza vaccination of healthy adults using a new microinjection system: a 3-year randomised controlled safety and immunogenicity trial
    Jiri Beran
    Vaccination and Travel Medicine Centre, Hradec Kralove, Czech Republic
    BMC Med 7:13. 2009
    ....
  17. ncbi Effect of repeated intradermal injections of heat-inactivated Mycobacterium bovis bacillus Calmette-Guérin in adult asthma
    P M Shirtcliffe
    Wellington School of Medicine and Health Sciences, Wellington, New Zealand
    Clin Exp Allergy 34:207-12. 2004
    ..There is also epidemiological and experimental evidence that exposure to mycobacteria has the potential to suppress the development of asthma/atopy...
  18. ncbi Immunogenicity and safety of intradermal influenza immunization at a reduced dose in healthy children
    Susan S Chiu
    Department of Pediatrics and Adolescent Medicine, University of Hong Kong, Hong Kong, China
    Pediatrics 119:1076-82. 2007
    ..We conducted this study to test the hypothesis that intradermal influenza vaccination at one fifth of a standard dose elicits comparable immunogenicity to full-dose intramuscular vaccination in children...
  19. ncbi Efficient induction of immune responses through intradermal vaccination with N-trimethyl chitosan containing antigen formulations
    Suzanne M Bal
    Division of Drug Delivery Technology, Leiden Amsterdam Center for Drug Research, Leiden University, The Netherlands
    J Control Release 142:374-83. 2010
    ..This demonstrates that TMC functions as an immune potentiator for antigens delivered via the skin...
  20. ncbi Direct priming and cross-priming contribute differentially to the induction of CD8+ CTL following exposure to vaccinia virus via different routes
    Xuefei Shen
    Program in Biochemistry, Department of Medicine, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
    J Immunol 169:4222-9. 2002
    ..c. or intradermal infection. Thus, classic MHC class I Ag presentation and cross-priming contribute differentially to the induction of CD8(+) CTLs following exposure to vaccinia virus via different routes...
  21. ncbi Neutrophils rapidly migrate via lymphatics after Mycobacterium bovis BCG intradermal vaccination and shuttle live bacilli to the draining lymph nodes
    Valérie Abadie
    Mycobacterial Genetics Unit, Institut Pasteur, 25 rue du Docteur Roux, 7724 Paris Cedex 15, France
    Blood 106:1843-50. 2005
    ..Thus, we provide in vivo evidence that neutrophils, like DCs or inflammatory monocytes, migrate via afferent lymphatics to lymphoid tissue and can shuttle live microorganisms...
  22. ncbi Assessment of the reproducibility of intradermal administration of capsaicin as a model for inducing human pain
    Andrew Hughes
    Experimental Medicine Group, AstraZeneca, Alderley Park, Macclesfield, Cheshire SK 10 4TG, England, UK
    Pain 99:323-31. 2002
    ..We conclude that the tolerability profile, and variability of i.d. capsaicin-induced pain is acceptable for pharmacological profiling of novel anti-nociceptive agents, with limited number of subjects...
  23. pmc Enhanced memory responses to seasonal H1N1 influenza vaccination of the skin with the use of vaccine-coated microneedles
    Yeu Chun Kim
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Emory University School of Medicine, Atlanta, Georgia 30332, USA
    J Infect Dis 201:190-8. 2010
    ..Morbidity and mortality due to influenza could be reduced by improved vaccination...
  24. ncbi Revision of the Thai Red Cross intradermal rabies post-exposure regimen by eliminating the 90-day booster injection
    Pakamatz Khawplod
    Queen Saovabha Memorial Institute, Thai Red Cross Society, 1871 Rama IV Road, Bangkok 10330, Thailand
    Vaccine 24:3084-6. 2006
    ..CPRV had been previously shown to be as immunogenic and effective as purified Vero cell rabies vaccine (PVRV)...
  25. ncbi Response properties of dorsal root reflexes in cutaneous C fibers before and after intradermal capsaicin injection in rats
    H R Weng
    The Department of Anesthesiology and Pain Medicine, The Division of Anesthesiology and Critical Care, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Neuroscience 132:823-31. 2005
    ..The role of C fiber DRRs in normal sensory transmission and during hyperalgesia is discussed...
  26. pmc Microneedle-based vaccines
    Mark R Prausnitz
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, GA 30332 0100, USA
    Curr Top Microbiol Immunol 333:369-93. 2009
    ....
  27. pmc Intradermal immunization improves protective efficacy of a novel TB vaccine candidate
    Susan L Baldwin
    Infectious Disease Research Institute, Seattle, WA 98104, USA
    Vaccine 27:3063-71. 2009
    ..This highlights the need to explore different routes of immunization based on the adjuvant formulations used...
  28. ncbi Rabies post-exposure prophylaxis vaccination with purified chick embryo cell vaccine (PCECV) and purified Vero cell rabies vaccine (PVRV) in a four-site intradermal schedule (4-0-2-0-1-1): an immunogenic, cost-effective and practical regimen
    Arvydas Ambrozaitis
    Infectious Diseases and Microbiology Department, Vilnius University, Vilnius, Lithuania
    Vaccine 24:4116-21. 2006
    ..These results demonstrate that a new four-site ID PEP regimen is a cost-effective and convenient alternative to IM (Essen or Zagreb) or ID (TRC or eight-site) regimens, especially using a 1 mL vial of vaccine (PCECV)...
  29. ncbi Coating formulations for microneedles
    Harvinder S Gill
    Wallace H Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Georgia Institute of Technology, Atlanta, GA 30332 0535, USA
    Pharm Res 24:1369-80. 2007
    ....
  30. ncbi Dermal infection with vaccinia virus reveals roles for virus proteins not seen using other inoculation routes
    David C Tscharke
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
    J Gen Virol 83:1977-86. 2002
    ..Thus, the intranasal and intradermal models are complementary tools for dissecting the genetic basis of VV virulence...
  31. pmc Comparative immunogenicity of trivalent influenza vaccine administered by intradermal or intramuscular route in healthy adults
    Robert B Belshe
    Saint Louis University Medical Center, St Louis, MO 63110, United States
    Vaccine 25:6755-63. 2007
    ..ID route was not superior to IM vaccine at inducing antibodies. ID vaccine induced significantly more local inflammatory response than IM vaccine...
  32. ncbi A randomized, double-blind, multicenter comparison of the efficacy and tolerability of Restylane versus Zyplast for the correction of nasolabial folds
    Rhoda S Narins
    Dermatology and Laser Center, White Plains, New York, USA
    Dermatol Surg 29:588-95. 2003
    ..Hyaluronic acid derivatives potentially offer improved longevity of correction and a reduced risk of immunogenicity and hypersensitivity...
  33. pmc Antibody response of patients after postexposure rabies vaccination with small intradermal doses of purified chick embryo cell vaccine or purified Vero cell rabies vaccine
    D J Briggs
    College of Veterinary Medicine, Kansas State University, USA
    Bull World Health Organ 78:693-8. 2000
    ..We conclude that PCECV is a safe and highly immunogenic vaccine for postexposure rabies vaccination when administered intradermally in 0.1-ml doses using the two-site method ("2,2,2,0,1,1") recommended by WHO...
  34. pmc Preclinical evaluation of microneedle technology for intradermal delivery of influenza vaccines
    Jason B Alarcon
    BD Technologies, Research Triangle Park, NC 27709, USA
    Clin Vaccine Immunol 14:375-81. 2007
    ..Altogether, the results demonstrate that microneedle-based i.d. delivery elicits antibody responses that are at least as strong as via i.m. injection and that, in many cases, dose sparing can be achieved by this new immunization method...
  35. ncbi Safety of modified vaccinia virus Ankara (MVA) in immune-suppressed macaques
    K J Stittelaar
    Institute of Virology, Erasmus University Rotterdam, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands
    Vaccine 19:3700-9. 2001
    ..These data suggest that MVA can safely be used as a basis for recombinant human vaccines, and that it is also safe for use in immunocompromised individuals...
  36. ncbi Evaluation of the clinical performance of a new intradermal vaccine administration technique and associated delivery system
    Philippe E Laurent
    BD Medical Pharmaceutical Systems, 11, rue Aristide Bergès, 38800 Le Pont de Claix, France
    Vaccine 25:8833-42. 2007
    ..These evaluations showed that microinjection system can make the practice of ID vaccination easy to perform, reliable and safe, thus setting the stage for broader clinical application of ID vaccine delivery...
  37. ncbi Dose sparing with intradermal injection of influenza vaccine
    Richard T Kenney
    IOMAI, Gaithersburg, MD 20878, USA
    N Engl J Med 351:2295-301. 2004
    ..The loss of half the U.S. supply of influenza vaccine due to contamination has created a critical shortage. Dose-sparing strategies that use intradermal delivery of vaccines may be one approach to consider...
  38. ncbi Intradermal influenza vaccine administered using a new microinjection system produces superior immunogenicity in elderly adults: a randomized controlled trial
    David Holland
    Centre for Clinical Research and Effective Practice, Middlemore Hospital, Auckland, New Zealand
    J Infect Dis 198:650-8. 2008
    ..Enhanced influenza vaccines are needed to provide improved protection for elderly individuals. The intradermal vaccination route was hypothesized to provide immunogenicity superior to that provided by the intramuscular vaccination route...
  39. ncbi Cutaneous DNA delivery and gene expression in ex vivo human skin explants via wet-etch micro-fabricated micro-needles
    James Birchall
    Welsh School of Pharmacy, Cardiff University, Gene Delivery Research Group, Cardiff CF10 3XF, UK
    J Drug Target 13:415-21. 2005
    ..A combination of this innovative gene delivery platform and the ex vivo skin culture model will be further exploited to optimise cutaneous DNA delivery and address fundamental questions regarding gene expression in skin...
  40. ncbi Mass vaccination: solutions in the skin
    G M Glenn
    IOMAI Corporation, Gaithersburg, MD 20878, USA
    Curr Top Microbiol Immunol 304:247-68. 2006
    ..The combination of the skin immune system, safe use of potent adjuvants and ease of delivery suggests that skin delivery of vaccines can address multiple unmet needs for mass vaccination scenarios...
  41. ncbi Serum antibody responses after intradermal vaccination against influenza
    Robert B Belshe
    Department of Internal Medicine, Division of Infectious Diseases and Immunology, Saint Louis University, St Louis, MO 63110, USA
    N Engl J Med 351:2286-94. 2004
    ..If found to be safe and immunogenic, reduced doses of influenza vaccine given by the intradermal route could increase the number of available doses of vaccine...
  42. ncbi Antibody responses after dose-sparing intradermal influenza vaccination
    Prasert Auewarakul
    Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
    Vaccine 25:659-63. 2007
    ....
  43. ncbi Efficacy of intradermal hepatitis B vaccination compared to intramuscular vaccination in hemodialysis patients
    Thawee Chanchairujira
    Renal Division, Department of Medicine, Siriraj Hospital, Bangkok, Thailand
    J Med Assoc Thai 89:S33-40. 2006
    ..The aim of the present study was to compare the efficacy of intradermal hepatitis B vaccination with intramuscular vaccination in hemodialysis patients...
  44. ncbi Intradermal influenza vaccination--can less be more?
    John R La Montagne
    N Engl J Med 351:2330-2. 2004
  45. ncbi Intradermal, epidermal and transcutaneous vaccination: from immunology to clinical practice
    Jean Francois Nicolas
    University Lyon 1, UFR Lyon Sud, IFR 128 Biosciences Lyon Gerland, Institut National de la Santé et de la Recherche Médicale U503, 21 Avenue Tony Garnier, Lyon Cedex 07, Lyon 69365, France
    Expert Rev Vaccines 7:1201-14. 2008
    ....
  46. ncbi Long-term anti-rabies antibody persistence following intramuscular or low-dose intradermal vaccination of young Vietnamese children
    Nguyen Cong Vien
    Center of Pediatrics, Development and Health, Children s Hospital No 2, Ho Chi Minh City, Viet Nam
    Trans R Soc Trop Med Hyg 102:294-6. 2008
    ..1 year after a primary series (Y0) and again 5 years later (Y5), either as intramuscular or 1/5th dose intradermal injections concomitant with diphtheria, tetanus, pertussis and oral poliomyelitis vaccines...
  47. ncbi Enhancement of cellular immune response to a prostate cancer DNA vaccine by intradermal electroporation
    Anna Karin Roos
    Cancer Center Karolinska R8 01, Immune and Gene Therapy Laboratory, Department of Oncology and Pathology, Karolinska Institute, Stockholm, Sweden
    Mol Ther 13:320-7. 2006
    ..This study demonstrates the applicability of intradermal electroporation as a delivery method for genetic cancer vaccines and other DNA vaccines relying on antigen-specific T cell induction...
  48. ncbi Prospective immunogenicity study of multiple intradermal injections of rabies vaccine in an effort to obtain an early immune response without the use of immunoglobulin
    Pakamatz Khawplod
    World Health Organization Collaborating Center for Research in Rabies, Queen Saovabha Memorial Institute, Thai Red Cross Society, Bangkok 10330, Thailand
    Clin Infect Dis 35:1562-5. 2002
    ..Administration of rabies immunoglobulin into and around bite wounds on the first day of rabies prophylaxis should remain the optimal postexposure treatment...
  49. ncbi Rabies as a traveler's risk, especially in high-endemicity areas
    Francois Xavier Meslin
    Department of Communicable Diseases, World Health Organization, Switzerland
    J Travel Med 12:S30-40. 2005
    ..This article,paper using a number of examples and recent data on dog bite incidence and vaccine availability in various parts of the world, provides guidance on how to assess the risk and proposes means to avoid or mitigate this risk...
  50. pmc Development of an ex vivo human skin model for intradermal vaccination: tissue viability and Langerhans cell behaviour
    Keng Wooi Ng
    Gene Delivery Research Group, Welsh School of Pharmacy, Cardiff University, Cardiff CF10 3NB, UK
    Vaccine 27:5948-55. 2009
    ..However, the use of split-thickness skin for vaccine formulation studies may not be appropriate because of the nature of the activation. Full-thickness skin explants are a more suitable model to assess cutaneous vaccination ex vivo...
  51. pmc Stabilization of influenza vaccine enhances protection by microneedle delivery in the mouse skin
    Fu Shi Quan
    Department of Microbiology and Immunology, and Yerkes Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS ONE 4:e7152. 2009
    ..We hypothesized that vaccine delivery to the skin using a patch containing vaccine-coated microneedles could be an attractive approach to improve influenza vaccination compliance and efficacy...
  52. ncbi Intradermal influenza vaccine for older adults: a randomized controlled multicenter phase III study
    Robert Arnou
    ALTI Clinical Research Network, 49000 Angers, France
    Vaccine 27:7304-12. 2009
    ..This intradermal influenza vaccine for older adults is a beneficial option for influenza protection, consistently enhancing antibody responses without compromising safety...
  53. ncbi Improved antibody responses in infants less than 1 year old using intradermal influenza vaccination
    Tetsu Sugimura
    Sugimura Children s Medical Clinic, Chikugo, Japan
    Vaccine 26:2700-5. 2008
    ..Intradermal administration reportedly elicited immune responses similar to or better than a standard intramuscular dose. We hypothesized that intradermal injection could achieve a better response in infants than subcutaneous injection...
  54. ncbi Preventing the incurable: Asian rabies experts advocate rabies control
    B Dodet
    Asian Rabies Expert Bureau, Dodet Bioscience, 66 cours Charlemagne, 69002 Lyon, France
    Vaccine 24:3045-9. 2006
  55. ncbi Granulomatous reaction after intradermal injections of hyaluronic acid gel
    Franco Rongioletti
    Arch Dermatol 139:815-6. 2003
  56. ncbi Sympathetic modulation of acute cutaneous flare induced by intradermal injection of capsaicin in anesthetized rats
    Qing Lin
    Department of Anatomy and Neurosciences, Marine Biomedical Institute, The University of Texas Medical Branch, Texas 77555 1069, USA
    J Neurophysiol 89:853-61. 2003
    ..Peripheral alpha(1)-adrenoceptors thus modulate the ability of capsaicin sensitive afferents to evoke the release of inflammatory agents from primary afferents by DRRs...
  57. ncbi Intradermal DNA immunization by using jet-injectors in mice and monkeys
    J Haensler
    Pasteur Mérieux Connaught France, Marcy l Etoile
    Vaccine 17:628-38. 1999
    ..In fact, local gene expression was 10-100 fold more important in the injected muscle as compared to the jet-injected skin when assessed by using the luciferase reporter system...
  58. ncbi Effect of vaccination route and composition of DNA vaccine on the induction of protective immunity against pseudorabies infection in pigs
    E M van Rooij
    Department of Mammalian Virology and Immunology, Institute for Animal Science and Health, Lelystad, Netherlands
    Vet Immunol Immunopathol 66:113-26. 1998
    ..Our data show that the route of administering DNA vaccines in pigs is important for an optimal induction of protective immunity...
  59. ncbi Sympathetic nervous modulation of the skin innate and adaptive immune response to peptidoglycan but not lipopolysaccharide: involvement of beta-adrenoceptors and relevance in inflammatory diseases
    Michela Manni
    Istituto Cantonale di Patologia, Center for Experimental Pathology, Via in Selva 24, P O Box, 6601 Locarno, Switzerland
    Brain Behav Immun 22:80-8. 2008
    ....
  60. ncbi Effect of cytokine-encoding plasmid delivery on immune response to Japanese encephalitis virus DNA vaccine in mice
    Kaushik Bharati
    National Institute of Immunology, New Delhi, India
    Microbiol Immunol 49:349-53. 2005
    ..However, intra-dermal co-administration of pMEa and pGM-CSF in mice using the gene gun, enhanced anti-JEV antibody titers resulting in an increased level of protection in mice against lethal JEV challenge...
  61. ncbi Quantitative comparison of the results obtained by the multiple-dose guinea pig maximization test and the non-radioactive murine local lymph-node assay for various biocides
    Tetsuo Yamano
    Osaka City Institute of Public Health and Environmental Sciences, 8 34 Tojo cho, Tennoji ku, Osaka 543 0026, Japan
    Toxicology 211:165-75. 2005
    ..73). The results suggest the possibility to estimate human elicitation-threshold doses, which are definitely lacking in the process of risk assessment for skin-sensitizers, from the data of the LLNA...
  62. ncbi Reporter gene expression in dendritic cells after gene gun administration of plasmid DNA
    Craig Watkins
    Division of Veterinary Biomedical Sciences, University of Edinburgh, Easter Bush Veterinary Centre, Easter Bush, Midlothian EH25 9RG, UK
    Vaccine 23:4247-56. 2005
    ..The plasmid was associated with both the cellular and fluid components of afferent lymph. EGFP protein appeared in afferent lymph in a pulsatile manner, but associated only with ALDC...
  63. pmc CpG motif acts as a 'danger signal' and provides a T helper type 1-biased microenvironment for DNA vaccination
    Ling Liu
    Key Laboratory of Medical Molecular Virology, Ministry of Education and Health, Shanghai Medical College, Fudan University, Shanghai, China
    Immunology 115:223-30. 2005
    ..These results may help to explain the mechanism of different types of immune response induced by DNA vaccines delivered by different routes and facilitate the application of DNA vaccines...
  64. ncbi Comparison of protective effect of protein and DNA vaccines hsp90 in murine model of systemic candidiasis
    M Raska
    Department of Immunology, Faculty of Medicine, Palacky University, Olomouc, Czechia
    Folia Microbiol (Praha) 50:77-82. 2005
    ..d. protein and DNA vaccination approaches. We stressed the importance of specific humoral immunity in the mouse model of systemic candidiasis...
  65. ncbi Immunogenicity of hylan g-f 20 in Guinea pigs and mice
    Masanori Sasaki
    Central Research Laboratories, Seikagaku Corporation, Tokyo, Japan
    J Rheumatol 31:943-50. 2004
    ..To determine the product-specific immunogenicity of a chemically-modified sodium hyaluronate derivative, hylan G-F 20, that is used in the treatment of osteoarthritis of the knee...
  66. ncbi Pivotal role of endogenous tachykinins and the NK1 receptor in mediating leukocyte accumulation, in the absence of oedema formation, in response to TNFalpha in the cutaneous microvasculature
    Soraia K P Costa
    Centre for Cardiovascular Biology and Medicine, King s College, Guy s Campus London SE1, 1UL, UK
    J Neuroimmunol 171:99-109. 2006
    ..The NK1 receptor agonist influences the accumulation of monocytes in addition to that of PMN by 4 h, thus revealing an important influence of the NK1 receptor on TNFalpha mediated events in mouse skin...
  67. ncbi Intradermal administration of thymic stromal lymphopoietin induces a T cell- and eosinophil-dependent systemic Th2 inflammatory response
    Heidi K Jessup
    Inflammation Research, Amgen, Seattle, WA 98119, USA
    J Immunol 181:4311-9. 2008
    ..TSLP-induced responses were significantly, but not completely reduced in IL-4- and IL-13-deficient mice. These results shed light on the pathways and cell types involved in TSLP-induced inflammation...
  68. ncbi Objective and subjective measurements of cutaneous inflammation after a novel hyaluronic acid injection
    Harryono Judodihardjo
    The Cellite Clinic Ltd, Cardiff, UK
    Dermatol Surg 34:S110-4. 2008
    ..However, after the injection of HA, there is normally a mild inflammatory reaction. All published studies to date have measured this unwanted side effect by subjective means only...
  69. ncbi [Hyaluronic acid]
    N Pomarede
    Ann Dermatol Venereol 135:1S35-8. 2008
    ....
  70. pmc Cluster intradermal DNA vaccination rapidly induces E7-specific CD8+ T-cell immune responses leading to therapeutic antitumor effects
    S Peng
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Gene Ther 15:1156-66. 2008
    ..Thus, our study has significant potential for future clinical translation...
  71. ncbi Fast and easy treatment for reduction of the Tyndall effect secondary to cosmetic use of hyaluronic acid
    Tracee Douse-Dean
    Chicago Cosmetic Surgery and Dermatology, Chicago, IL 60610, USA
    J Drugs Dermatol 7:281-3. 2008
    ..A number of treatments can be performed to reverse these unwanted effects. We present a simple method for correction of misplacement of HA gel...
  72. doi Eosinophilic granulomatous reaction after intradermal injection of hyaluronic acid
    Shuko Okada
    Acta Derm Venereol 88:69-70. 2008
  73. ncbi Evaluation of the Friend Virus model for the development of improved adenovirus-vectored anti-retroviral vaccination strategies
    Wibke Bayer
    Ruhr University Bochum, Institute of Microbiology and Hygiene, Department of Molecular and Medical Virology, Building MA, Room 6 40, D 44801 Bochum, Germany
    Vaccine 26:716-26. 2008
    ..Our results suggest that the FV model can provide insight into the development of improved adenovirus vectors for HIV-1 vaccination...
  74. ncbi [Use of biophysical techniques to evaluate the physiologic effects of injected hyaluronic acid]
    T Reuther
    Kosmetik und Körperpflege FB 13, Universitat Hamburg, Martin Luther King Platz 6, 20146, Hamburg, Germany
    Hautarzt 58:1046-50. 2007
    ..To evaluate the effects of intradermal injection of native hyaluronic acid on physiology of aged skin using bioengineering methods...
  75. ncbi Dermal fillers for facial soft tissue augmentation
    Sarosh F Dastoor
    Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan 1011 North University Avenue, Ann Arbor, MI 48109, USA
    J Oral Implantol 33:191-204. 2007
    ..This article will review the pathogenesis of facial wrinkles, history, techniques, materials, complications, and clinical controversies regarding dermal fillers for soft tissue augmentation...
  76. ncbi Optimisation of intradermal DNA electrotransfer for immunisation
    Gaëlle Vandermeulen
    Universite Catholique de Louvain, Unite de Pharmacie Galenique, Avenue Emmanuel Mounier, 73 UCL, 7320, B 1200 Brussels, Belgium
    J Control Release 124:81-7. 2007
    ..Nevertheless electrotransfer into the skin, the muscle and the ear pinna all resulted in IFN-gamma secretion by luciferase-stimulated splenocytes suggesting that an efficient Th1 response was induced in all case...
  77. ncbi Enhancement of antibody and cellular immune responses to malaria DNA vaccines by in vivo electroporation
    Carlota Dobano
    Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910 7500, United States
    Vaccine 25:6635-45. 2007
    ..Moreover, IFN-gamma responses were increased by approximately 2-fold. Data demonstrate the potential of EP to enhance immune responses to DNA vaccines against infectious agents...
  78. ncbi [Use the hyaluronic acid according to the concept Face Recurve: vacuum technical and interpores technical]
    C Le Louarn
    Chirurgie plastique reconstructrice et esthétique, Cabinet médical Le Louarn, 59, rue Spontini, 75116 Paris, France
    Ann Chir Plast Esthet 53:278-80. 2008
    ....
  79. ncbi Understanding the anatomy when using dermal fillers enhances patient safety
    Tracey Hotta
    Plast Surg Nurs 26:149-51. 2006
  80. ncbi Needle-free injection of DNA vaccines: a brief overview and methodology
    Kanakatte Raviprakash
    Viral Diseases Department, Naval Medical Research Center, Silver Spring, MD, USA
    Methods Mol Med 127:83-9. 2006
    ..This approach requires no additional development, and with an expanding market and willingness from jet injector manufacturers to produce prefilled syringes, the technique should become feasible for larger phase II/phase III trials...
  81. ncbi Comparative evaluation of CD8+CTL responses following gene gun immunization targeting the skin with intracutaneous injection of antigen-transduced dendritic cells
    Evelyn Gaffal
    Laboratory of Experimental Dermatology, Department of Dermatology, University of Bonn, Sigmund Freud Street 25, D 53105 Bonn, Germany
    Eur J Cell Biol 86:817-26. 2007
    ..Further investigations will have to address the role of Langerhans cells for the activation of cellular immunity in the skin...
  82. ncbi Enhanced antigen-specific antibody production following polyplex-based DNA vaccination via the intradermal route in mice
    Atsushi Kawase
    Department of Biopharmaceutics and Drug Metabolism, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Vaccine 24:5535-45. 2006
    ..Thus, the present study has demonstrated that the immune responses could be biased towards a Th2-type response by polyplex-based DNA vaccination through manipulation of not only pDNA disposition but also dendritic cell migration...
  83. ncbi Vascular endothelial growth factor and soluble FLT-1 receptor interactions and biological implications
    Maciej Malecki
    Department of Cell Biology, Centre of Oncology, Maria Sklodowska Curie Memorial Institute, W K Roentgen 5, 02 781 Warsaw, Poland
    Oncol Rep 14:1565-9. 2005
    ..The results obtained from in vivo angiogenesis tests also confirm the antiangiogenic potency of cloned sFLT-1, which can be useful for planning cancer experimental therapy studies...
  84. ncbi Histamine H4 receptors modulate dendritic cell migration through skin--immunomodulatory role of histamine
    W Baumer
    Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine, Hannover Foundation, Hannover, Germany
    Allergy 63:1387-94. 2008
    ..However, the distribution of histamine receptors on murine DC has not been studied yet...
  85. pmc Toll-like receptor-9 induced by physical trauma mediates release of cytokines following exposure to CpG motif in mouse skin
    Ling Liu
    Key Laboratory of Medical Molecular Virology, Ministry of Education and Health, Shanghai Medical College, Fudan University, Shanghai, China
    Immunology 110:341-7. 2003
    ..This role of TLR9 may help explain the previously identified enhancement of DNA immunization by CpG ODN...
  86. ncbi Localized in vivo genotypic and phenotypic correction of the albino mutation in skin by RNA-DNA oligonucleotide
    V Alexeev
    Department of Dermatology and Cutaneous Biology, Jefferson Institute of Molecular Medicine, Thomas Jefferson University and Jefferson Medical College, Philadelphia PA 19107, USA
    Nat Biotechnol 18:43-7. 2000
    ..Localized gene correction was maintained three months after the last application of the chimeric oligonucleotides. These results demonstrated correction of the tyrosinase gene point mutation by chimeric oligonucleotides in vivo...
  87. ncbi Immune modulation in pemphigus vulgaris: role of CD28 and IL-10
    P Toto
    Department of Dermatology, University G D Annunzio, Chieti, Italy
    J Immunol 164:522-9. 2000
    ..To confirm that IL-10 is involved in the pathogenesis, rIL-10 was given with PV IgG. IL-10 significantly suppressed the disease activity. These data suggest a potential role of IL-10 in PV...
  88. ncbi Hylan G-F 20 induces delayed foreign body inflammation in Guinea pigs and rabbits
    Masanori Sasaki
    Central Research Laboratories, Seikagaku Corporation, Tokyo, Japan
    Toxicol Pathol 31:321-5. 2003
    ..The present results contradict previous reports on biocompatibility of hylan and suggest that hylan may potentially induce similar unfavorable reactions in humans...
  89. ncbi A randomized, double-blind, placebo controlled study on analgesic effects of botulinum toxin A
    B Voller
    Department of Clinical Pharmacology, University of Vienna, Austria
    Neurology 61:940-4. 2003
    ..Botulinum toxin type A (BTXA) is used to treat neurologic disorders associated with increased muscle tone. Its use is often associated with pain relief...
  90. ncbi Immunization with DNA through the skin
    Kristina K Peachman
    Department of Membrane Biochemistry, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Room 2A24, Silver Spring, MD 20910 7500, USA
    Methods 31:232-42. 2003
    ..immunization or non-invasive vaccination of the skin); (d) gene gun technology; (e) electroporation; (f) intradermal injections; and (g) microseeding...
  91. ncbi Gene gun bombardment with gold particles displays a particular Th2-promoting signal that over-rules the Th1-inducing effect of immunostimulatory CpG motifs in DNA vaccines
    Richard Weiss
    Institute of Chemistry and Biochemistry, University of Salzburg, Hellbrunner Street 34, A 5020 Salzburg, Austria
    Vaccine 20:3148-54. 2002
    ..Furthermore, the data also indicate a strong and even systemic adjuvant effect of the gene gun shot itself...
  92. ncbi Induction of cytotoxic T-lymphocytes specific for bovine herpesvirus-1 by DNA immunization
    Muralidhar S Deshpande
    Department of Veterinary and Biomedical Sciences, University of Nebraska at Lincoln, Lincoln, NE 68583, USA
    Vaccine 20:3744-51. 2002
    ..These results indicate the feasibility of using a plasmid carrying the gene encoding BHV-1 gD as an immunogen to induce CTLs against BHV-1...
  93. ncbi DNA immunization via intramuscular and intradermal routes using a gene gun provides different magnitudes and durations on immune response
    Koichi Ito
    Department of Immunology, Japan Science and Technology Corporation JST, Kitasato University School of Medicine, 1 15 1 Kitasato, Sagamihara, Kanagawa 228 8555, Japan
    Mol Immunol 39:847-54. 2003
    ....
  94. ncbi A kinetic analysis of immune mediators in the lungs of mice infected with vaccinia virus and comparison with intradermal infection
    Patrick C Reading
    Department of Virology, Faculty of Medicine, Imperial College London, St Mary s Campus, Norfolk Place, London W2 1PG, UK
    J Gen Virol 84:1973-83. 2003
    ..Together these findings highlight differences in the pathogenesis and in the cellular inflammatory response to WR following intranasal and intradermal inoculation of mice...
  95. ncbi IL-10 regulates early IL-12-mediated immune responses induced by the radiation-attenuated schistosome vaccine
    Karen G Hogg
    Department of Biology Area 5, PO Box 373, University of York, York YO10 5YW, UK
    Int Immunol 15:1451-9. 2003
    ....
  96. ncbi Inducible expression of a CC chemokine liver- and activation-regulated chemokine (LARC)/macrophage inflammatory protein (MIP)-3 alpha/CCL20 by epidermal keratinocytes and its role in atopic dermatitis
    T Nakayama
    Department of Bacteriology, Kinki University School of Medicine, Osaka Sayama 589 8511, Japan
    Int Immunol 13:95-103. 2001
    ..LARC/CCL20 may not, however, play a major role in homeostatic migration of Langerhans cells into the skin...
  97. ncbi Enhancement of both cellular and humoral responses to genetic immunization by co-administration of an antigen-expressing plasmid and a plasmid encoding the pro-apoptotic protein Bax
    Berma M Kinsey
    Veterans Affairs Medical Center, Center for AIDS Research, and Department of Internal Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    J Gene Med 6:445-54. 2004
    ..It has been known for some time that when dendritic cells phagocytose apoptotic bodies derived from tumor cells, an immune response to tumor antigens can be generated...
  98. ncbi In vivo electroporation using an exponentially enhanced pulse: a new waveform
    M L Lucas
    Department of Medical Microbiology and Immunology/Institute for Biomolecular Science, University of South Florida, Tampa, Florida 33612, USA
    DNA Cell Biol 20:183-8. 2001
    ..This is the first report of this new waveform and shows the success of using protocols employing the EEP to deliver plasmid DNA to various tissue types...
  99. ncbi IL-11 protects human microvascular endothelium from alloinjury in vivo by induction of survivin expression
    Nancy C Kirkiles-Smith
    Interdepartmental Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine and Department of Pathology, Yale University School of Medicine, New Haven CT 06510, USA
    J Immunol 172:1391-6. 2004
    ..We conclude that in this human transplant model, IL-11 exerts a cytoprotective rather than anti-inflammatory or immunomodulatory effect mediated through induction of survivin...
  100. ncbi Purification and characterisation of a haemorrhagic fraction from the venom of the Uracoan rattlesnake Crotalus vegrandis
    I Aguilar
    Tropical Medicine Institute, Immunochemistry Section, Universidad Central de Venezuela, Caracas, Venezuela
    Biochim Biophys Acta 1548:57-65. 2001
    ..In addition, Uracoina-1 is myotoxic, lacking haemolytic, defibrinating and lethal effects. The N-terminal amino acid sequence (20 residues) was determined...
  101. ncbi Injectable treatments for the aging face
    Jeffrey B Wise
    Division of Facial Plastic and Reconstructive Surgery, Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania School of Medicine, Philadelphia, USA
    Facial Plast Surg 22:140-6. 2006
    ....

Research Grants62

  1. Delivery of biologically active nucleic acids to epidermal cells
    ROGER L contact KASPAR; Fiscal Year: 2010
    ..Delivery appears to be the major obstacle to progress in developing nucleic acid therapeutics for skin. Intradermal injections appear to deliver nucleic acids to epidermal cells, but the large cutaneous surface makes such an approach ..
  2. Protein Therapy for Recessive Dystrophic Epidermolysis Bullosa
    David T Woodley; Fiscal Year: 2010
    ..With C7 protein therapy, we showed that intradermal injections of recombinant C7 into human RDEB skin equivalents transplanted onto athymic mice stably restored C7 ..
  3. Molecularly guided multimodal theranostics for breast cancer
    Amit Joshi; Fiscal Year: 2013
    ..Swine based animal model for detecting lymph node locations in three dimensions, following microdose intradermal injections of nanoshell conjugated fluorescent dyes...
  4. DERMAL CHOLINERGIC RECEPTORS AND ALZHEIMER'S DISEASE
    HELENA RYER; Fiscal Year: 1992
    ..dermal cholinergic function will be correlated with in vivo measures of eccrine sweat gland sensitivity to intradermal injections of carbachol (a muscarinic agonist) and choline (a acetylcholine precursor)...
  5. Phase I Study of Dendritic Cell Immunotherapy
    Linda Liau; Fiscal Year: 2002
    ..The specific aims of our project are: 1) to determine the feasibility, safety and toxicity of intradermal injections of autologous peptide-pulsed dendritic cells in patients with CNS gliomas; 2) to monitor tumor progression ..
  6. PROPER UTILIZATION OF FREUND'S COMPLETE ADJUVENT
    Harold Stills; Fiscal Year: 1990
    ..Lesion quantitation will be done non-invasively by caliper measurement for intradermal injections and by ultrasound examination for subcutaneous and intramuscular sites...
  7. AUTOLOGOUS HAPTEN MODIFIED VACCINE FOR HUMAN CANCER
    David Berd; Fiscal Year: 2001
    ..This work may lead to the development of reagents useful in identifying the target antigens. ..
  8. Immune Responses to Biodefense Vaccines Early in Life
    Marcela F Pasetti; Fiscal Year: 2010
    ..It will also provide knowledge to better understand the mechanisms mediating neonatal-infant immunity to develop more effectivevaccines to prevent diseases early in life. ..
  9. Acellular vaccines against Francisella tularensis
    Wayne Conlan; Fiscal Year: 2005
    ..It is expected that the findings from the proposed studies will be applicable to the development of acellular vaccines against other intracellular respiratory pathogens such as Mycobacterium tuberculosis, and Chlamydia pneumoniae. ..
  10. Phase II trial of 17-AAG in melanoma patients
    Paul Chapman; Fiscal Year: 2007
    ..post-treatment specimens, clinically responding tumors vs. non-responding tumors, and mutant BRAF vs. wild-type BRAF tumors. [unreadable] [unreadable] [unreadable]..
  11. International Symposium on Cancer Metastasis and the Lymphovascular System
    STANLEY LEONG; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  12. Human Metapneumovirus Infection in Adults
    ANN FALSEY; Fiscal Year: 2007
    ..abstract_text> ..
  13. Satellite Glial and Sensory Coding: Implications for Pain
    ROBERT LA MOTTE; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  14. 5-Day Fiber-Coupled Sensor Interstitial Glucose
    Ralph Ballerstadt; Fiscal Year: 2006
    ..We believe the proposed sensor can provide a solution for short-term (3-5 days) continuous monitoring that will be accurate, reliable, and convenient for patient use. [unreadable] [unreadable] [unreadable]..
  15. Nanoparticle-Based Optical Sensor for Glucose Monitoring
    Ralph Ballerstadt; Fiscal Year: 2006
    ..abstract_text> ..
  16. Vulvar vestibulitis trial: Desipramine-Lidocaine
    David Foster; Fiscal Year: 2006
    ..equally effective or is one superior to the other? Is there any benefit from combined local and systemic treatments? And finally, do genetic characteristics and tissue cytokine concentrations influence treatment response? ..
  17. Chromium and Insulin Action
    William Cefalu; Fiscal Year: 2006
    ..abstract_text> ..
  18. Anti-GD3 NKT cells as effector cells against melanoma
    Paul Chapman; Fiscal Year: 2006
    ..This will provide initial support for an immunotherapeutic approach based on antigen-specific NKT cells. [unreadable] [unreadable]..
  19. Biobehavioral-Cytokine Interactions in Ovarian Cancer
    Susan Lutgendorf; Fiscal Year: 2007
    ..Findings will have implications for innovative behavioral and pharmacological intervention strategies for ovarian cancer patients. ..
  20. New genetic approaches analyzing Borrelia burgdorferi
    Jon Blevins; Fiscal Year: 2007
    ..This proposal thus seeks to contribute major new advances to borrelial genetics and to use those developments to examine potentially novel aspects of Bb virulence expression. [unreadable] [unreadable]..
  21. SYNAPTIC CONNECTIONS OF SPINAL CORD NEURONS
    William Willis; Fiscal Year: 2007
    ..Preliminary evidence supports the feasibility of the work and suggests that the results could lead to a number of new targets for improvements in pain therapy. ..
  22. Chromium, Cellular Energy Status and Whole Body Energy Balance
    William Cefalu; Fiscal Year: 2007
    ..abstract_text> ..
  23. Role of ASIC3 in the etiology of fibromyalgia
    Kathleen A Sluka; Fiscal Year: 2010
    ..These studies could lead to peripherally based therapeutic approaches to control pain without undesirable CMS (central nervous system) side effects, including gene therapy. ..
  24. Central contributions to pathobiology of fibromyalgia
    Kathleen Sluka; Fiscal Year: 2009
    ..A better understanding of the pathobiological mechanisms underlying musculoskeletal pain conditions may lead to the development of novel therapeutic approaches for its treatment. ..
  25. PHAGOCYTE RESOLVING METABOLISM
    Charles Serhan; Fiscal Year: 2009
    ..abstract_text> ..
  26. Aberrant T Cell Function and Immunopathogenesis of CMV Immune Recovery Uveitis
    Mark Jacobson; Fiscal Year: 2008
    ..Thus, understanding the disease mechanism of CMV IRU could facilitate development of effective therapy for CMV IRU or diagnostic or treatment strategies to prevent CMV IRU. [unreadable] [unreadable] [unreadable]..
  27. Investigating aging and membrane-associated T cell receptor signaling in human CD
    Insoo Kang; Fiscal Year: 2008
    ..The results of this study will provide important information on enhancing immune responses in the aged populations, leading to improved protection against infections and tumors. [unreadable] [unreadable] [unreadable]..
  28. Fluorescence Sensor Probe for Transcutaneous Glucose Sensing
    Ralph Ballerstadt; Fiscal Year: 2008
    ..The overall result will be a healthier life for people with diabetes and lower medical costs for diabetes care for the society. [unreadable] [unreadable] [unreadable]..
  29. HIV Epitope Specific T Cell Responses and Control of HIV Replication
    Mark Jacobson; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  30. 4th International Workshop for the Study of Itch
    Earl Carstens; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  31. APS Travel Award
    Kathleen Sluka; Fiscal Year: 2007
    ..C. These funds will allow trainees to attend and interact with both clinicians and researchers from multiple disciplines including medicine, nursing, psychology, and physical therapy. [unreadable] [unreadable] [unreadable]..
  32. Enhancing the Placebo Effect in Irritable Bowel Syndrome
    Ted Kaptchuk; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  33. An Integrative Healing Model in IBS
    Ted Kaptchuk; Fiscal Year: 2005
    ..abstract_text> ..
  34. CALORIC RESTRICTION, AGING, AND INSULIN ACTION
    William Cefalu; Fiscal Year: 2001
    ....
  35. NEUROBIOLOGY OF CHRONIC MUSCLE PAIN
    Kathleen Sluka; Fiscal Year: 2003
    ..These proposed studies will help in the understanding and thus potential treatment of chronic muscle pain, including such conditions as fibromyalgia, myofascial pain and low back pain. ..
  36. IMMUNIZATION AGAINST TUMOR CELL ANTIGENS
    Paul Chapman; Fiscal Year: 2003
    ..This close mentoring relationship reflects our current teaching paradigm. The grant award will provide the PI with more time to conduct the clinical trials and to mentor additional beginning clinical investigators. ..
  37. PATIENT ORIENTED RESEARCH IN CUTANEOUS ONCOLOGY
    Stuart Lessin; Fiscal Year: 2003
    ..Lessin to continue to participate in the ongoing departmental and institutional POR programs and serve as a role model and mentor for young investigators in POR at the University of Pennsylvania. ..
  38. Neurobiology of Joint Manipulation Induced Analgesia
    Kathleen Sluka; Fiscal Year: 2003
    ..This information will further assist the clinician in determining the treatment of choice for a particular patient and potentially guide future clinical research. ..
  39. TRANSCUTANEOUS IMMUNIZATION FOR TETANUS BOOSTER
    Gregory Glenn; Fiscal Year: 2003
    ..Additionally, the Transcutaneous booster will decrease the risk of needle-sticks and related disease, and reduce personnel and equipment requirements related to tetanus immunization. ..
  40. HORMONE REPLACEMENT FOR PREVENTION OF VISCERAL OBESITY
    William Cefalu; Fiscal Year: 2002
    ....
  41. DEXASOME BASED IMMUNOTHERAPY OF LUNG CANCER
    Michael Morse; Fiscal Year: 2002
    ..This clinical trial will form the background for further trials designed to demonstrate both immunology and clinical benefits of dexosome-based immunotherapy. ..
  42. NEURAL MECHANISMS FOR THE TACTUAL PERCEPTION OF SOFTNESS
    ROBERT LA MOTTE; Fiscal Year: 2002
    ....
  43. Healing Touch and Immunity in Advanced Cervical Cancer
    Susan Lutgendorf; Fiscal Year: 2002
    ....
  44. MICROFABRICATED MICRONEEDLES FOR DRUG DELIVERY
    MARK PRAUSNITZ; Fiscal Year: 2001
    ..g., proteins, DNA) over hours to days. ..
  45. Common Mediators of Vascular Calcification and Bone Dis*
    Cecilia Giachelli; Fiscal Year: 2004
    ..Aim 3 will determine the effect of hyperlipidemia on cartilaginous metaplasia, vascular calcification and osteoporosis in a mouse model of atherosclerosis...
  46. Dendritic Cell Immunotherapy for Cervical Cancer
    Alessandro Santin; Fiscal Year: 2004
    ..This study will determine whether E7 antigen-loaded autologous DC vaccination offers the potential of therapeutic benefit for patients with HPV16 or HPV18-associated cervical cancer. ..
  47. Healing Touch, Immunity, and Fatigue in Breast Cancer
    Susan Lutgendorf; Fiscal Year: 2004
    ....
  48. SYNTHETIC STUDIES RELATED TO CANCER RESEARCH/TREATMENT
    Paul Wender; Fiscal Year: 2005
    ..Overall, this research program is expected to be of significant value in chemistry, biology, and medicine. ..
  49. Neurobiology of Musculoskeletal Pain
    Kathleen Sluka; Fiscal Year: 2005
    ..These proposed studies are intended to help in the understanding and thus potential treatment of chronic muscle pain including such conditions as fibromyalgia, myofascial pain and low back pain. ..
  50. Mouse model of oral infection with virulent Francisella
    Wangxue Chen; Fiscal Year: 2005
    ..tularensis infection so that future hypothesis-driven studies with more focused research objectives can be designed and developed. ..
  51. CMV Immune Response & Long-Term Outcome of CMV Retinitis
    Mark Jacobson; Fiscal Year: 2005
    ....
  52. Symposium on Cancer Metastasis and Lymphovascular System
    STANLEY LEONG; Fiscal Year: 2004
    ..abstract_text> ..
  53. FRZB PROFILES AS OSTEOARTHRITIS BIOMARKERS
    MARY CORR; Fiscal Year: 2004
    ..The results of these studies will both contribute to, and will utilize, the resources of the OA biomarker consortium. ..
  54. SHAM DEVICE, PILL PLACEBO OR TREATMENT FOR ARM PAIN
    Ted Kaptchuk; Fiscal Year: 2003
    ..Outcomes in these studies will include assessments of the nature and severity of upper extremity pain, function, grip and pinch strength, and mood. ..
  55. Formulated Patch for Topical Influenza Vaccine
    Gregory Glenn; Fiscal Year: 2004
    ..Needle-free may also aid in the extension of use of a flu patch into the pediatric population where influenza immunization is now recommended by the ACIP and will be a subsequent goal of this development program. ..
  56. A Phase 1 Study/DNA-Based Vaccine vs Prostatic Acid Pase
    Douglas McNeel; Fiscal Year: 2006
    ..This trial will serve as a platform and model for clinical trial evaluation of antigens identified in the second aim of the proposal. ..
  57. Mechanisms of Ultrasound-Mediated Bioeffects
    MARK PRAUSNITZ; Fiscal Year: 2006
    ..During the final year, mechanistic findings will be used to design and test ultrasound protocols that optimize molecular uptake and cell viability. ..
  58. Trigeminal Mechanisms of Oral Irritation
    Earl Carstens; Fiscal Year: 2009
    ..In a corresponding animal study, we will determine if responses of neurons in the n. tractus solitarius (NTS), a taste relay, are reduced by intraoral capsaicin ..
  59. PARTIAL RHIZOTOMY EFFECTS ON SPINAL GANGLIA
    ROBERT LA MOTTE; Fiscal Year: 2002
    ....
  60. MICROFABRICATED MICRONEEDLES FOR DRUG DELIVERY
    MARK PRAUSNITZ; Fiscal Year: 2003
    ..g., proteins, DNA) over hours to days. ..
  61. Adjunct rhIL-12 enhance THI response to viral vaccine?
    Mark Jacobson; Fiscal Year: 2004
    ..g. CMV, HSV and HIV). ..
  62. Transcutaneous Immunization for an Anthrax Vaccine
    Gregory Glenn; Fiscal Year: 2005
    ....