spinal injections

Summary

Top Publications

  1. pmc Transient allodynia pain models in mice for early assessment of analgesic activity
    D W Gil
    Department of Biological Sciences, Allergan Inc, Irvine, CA, USA
    Br J Pharmacol 153:769-74. 2008
  2. ncbi Neurologic complications associated with intrathecal liposomal cytarabine given prophylactically in combination with high-dose methotrexate and cytarabine to patients with acute lymphocytic leukemia
    Elias Jabbour
    Department of Leukemia, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Blood 109:3214-8. 2007
  3. ncbi Evidence that exogenous and endogenous fractalkine can induce spinal nociceptive facilitation in rats
    E D Milligan
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Eur J Neurosci 20:2294-302. 2004
  4. ncbi Spinal glia and proinflammatory cytokines mediate mirror-image neuropathic pain in rats
    Erin D Milligan
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, Colorado 80309 0345, USA
    J Neurosci 23:1026-40. 2003
  5. ncbi Intrathecal ziconotide in the treatment of refractory pain in patients with cancer or AIDS: a randomized controlled trial
    Peter S Staats
    Division of Pain Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    JAMA 291:63-70. 2004
  6. ncbi Pharmacologic interaction between cannabinoid and either clonidine or neostigmine in the rat formalin test
    Myung Ha Yoon
    Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School, Gwanju, Korea
    Anesthesiology 99:701-7. 2003
  7. ncbi Spinal gap junctions: potential involvement in pain facilitation
    Leah E Spataro
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, Colorado 90309 0345, USA
    J Pain 5:392-405. 2004
  8. ncbi Perispinal TNF-alpha inhibition for discogenic pain
    Edward L Tobinick
    Institute for Neurological Research, Los Angeles, California, USA
    Swiss Med Wkly 133:170-7. 2003
  9. ncbi Intrathecal liposomal cytarabine for prevention of meningeal disease in patients with acute lymphocytic leukemia and high-grade lymphoma
    Brian McClune
    Leuk Lymphoma 48:1849-51. 2007
  10. ncbi Efficiencies of transgene expression in nociceptive neurons through different routes of delivery of adeno-associated viral vectors
    Ya Xu
    Marine Biomedical Institute, University of Texas Medical Branch, Galveston, TX 77555, USA
    Hum Gene Ther 14:897-906. 2003

Detail Information

Publications215 found, 100 shown here

  1. pmc Transient allodynia pain models in mice for early assessment of analgesic activity
    D W Gil
    Department of Biological Sciences, Allergan Inc, Irvine, CA, USA
    Br J Pharmacol 153:769-74. 2008
    ..Transient models of chemically sensitized allodynia are potentially useful for rapidly characterizing the analgesic profile of compounds and conducting mechanistic studies...
  2. ncbi Neurologic complications associated with intrathecal liposomal cytarabine given prophylactically in combination with high-dose methotrexate and cytarabine to patients with acute lymphocytic leukemia
    Elias Jabbour
    Department of Leukemia, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Blood 109:3214-8. 2007
    ..Liposomal cytarabine given via intrathecal route concomitantly with systemic chemotherapy that crosses the blood-brain barrier such as high-dose MTX and cytarabine can result in significant neurotoxicity...
  3. ncbi Evidence that exogenous and endogenous fractalkine can induce spinal nociceptive facilitation in rats
    E D Milligan
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Eur J Neurosci 20:2294-302. 2004
    ..Taken together, these initial investigations of spinal fractalkine effects suggest that exogenous and endogenous fractalkine are involved in spinal sensitization, including that induced by peripheral neuropathy...
  4. ncbi Spinal glia and proinflammatory cytokines mediate mirror-image neuropathic pain in rats
    Erin D Milligan
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, Colorado 80309 0345, USA
    J Neurosci 23:1026-40. 2003
    ..These results provide the first evidence that ipsilateral and mirror-image inflammatory neuropathy pain are created both acutely and chronically through glial and proinflammatory cytokine actions...
  5. ncbi Intrathecal ziconotide in the treatment of refractory pain in patients with cancer or AIDS: a randomized controlled trial
    Peter S Staats
    Division of Pain Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    JAMA 291:63-70. 2004
    ..Ziconotide (formerly SNX-111) selectively blocks N-type voltage-sensitive calcium channels and may be effective in patients with pain that is refractory to opioid therapy or those with intolerable opioid-related adverse effects...
  6. ncbi Pharmacologic interaction between cannabinoid and either clonidine or neostigmine in the rat formalin test
    Myung Ha Yoon
    Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School, Gwanju, Korea
    Anesthesiology 99:701-7. 2003
    ....
  7. ncbi Spinal gap junctions: potential involvement in pain facilitation
    Leah E Spataro
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, Colorado 90309 0345, USA
    J Pain 5:392-405. 2004
    ..In addition, it decreased gp120-induced proinflammatory cytokines. This suggests gap junction activation might lead to proinflammatory cytokine release by distantly activated glia...
  8. ncbi Perispinal TNF-alpha inhibition for discogenic pain
    Edward L Tobinick
    Institute for Neurological Research, Los Angeles, California, USA
    Swiss Med Wkly 133:170-7. 2003
    ..To examine the potential of etanercept, a biological inhibitor of tumour necrosis factor-alpha (TNF), delivered by perispinal administration, for the treatment of pain associated with intervertebral disc disease...
  9. ncbi Intrathecal liposomal cytarabine for prevention of meningeal disease in patients with acute lymphocytic leukemia and high-grade lymphoma
    Brian McClune
    Leuk Lymphoma 48:1849-51. 2007
  10. ncbi Efficiencies of transgene expression in nociceptive neurons through different routes of delivery of adeno-associated viral vectors
    Ya Xu
    Marine Biomedical Institute, University of Texas Medical Branch, Galveston, TX 77555, USA
    Hum Gene Ther 14:897-906. 2003
    ..These results suggest that delivering therapeutic genes to DRGs by the rAAV-NSE vector is a valid strategy for treatment of chronic pain...
  11. ncbi The ability of diagnostic spinal injections to predict surgical outcomes
    Steven P Cohen
    Pain Management Division, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Anesth Analg 105:1756-75, table of contents. 2007
    Since their first description more than 80 yr ago, the use of diagnostic spinal injections to predict surgical outcomes has been the subject of intense controversy...
  12. ncbi Lumbar catheterization of the spinal subarachnoid space in the rat
    R V Størkson
    Department of Physiology, University of Bergen, Norway
    J Neurosci Methods 65:167-72. 1996
    ....
  13. ncbi Improved outcome for children with acute lymphoblastic leukemia: results of Total Therapy Study XIIIB at St Jude Children's Research Hospital
    Ching Hon Pui
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Blood 104:2690-6. 2004
    ..01% or more at the end of the 6-week remission induction phase. Our results suggest the efficacy of early intensification of intrathecal chemotherapy and provide the basis for studies omitting cranial irradiation altogether...
  14. ncbi The dual effect of a nitric oxide donor in nociception
    A M Sousa
    Department of Pharmacology, , USP, Av. Bandeirantes 3900, 149049-900, SP, , Brazil
    Brain Res 897:9-19. 2001
    ..The effects of SIN-1 vary depending on the dose and pain model utilized, but its most sensitive effect seems to be antinociception. However, high doses of the NO-donor can intensify ongoing pain...
  15. ncbi Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptor
    P W Mantyh
    Molecular Neurobiology Laboratory 151, Veterans Administration Medical Center, Minneapolis, MN 55417, USA
    Science 278:275-9. 1997
    ..Thus, lamina I spinal cord neurons that express the substance P receptor play a pivotal role in the transmission of highly noxious stimuli and the maintenance of hyperalgesia...
  16. ncbi Intrathecal but not intravenous opioids release adenosine from the spinal cord
    James C Eisenach
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    J Pain 5:64-8. 2004
    ..In contrast, adenosine concentrations were unaffected by intravenous remifentanil. These results suggest that intrathecal but not systemic opioid analgesia in humans is associated with spinal release of adenosine...
  17. ncbi Spinal blockade of TNF blocks spinal nerve ligation-induced increases in spinal P-p38
    Camilla I Svensson
    Anesthesiology Research Labs, University of California, San Diego, La Jolla, CA 92093 0818, USA
    Neurosci Lett 379:209-13. 2005
    ..Combined systemic and intrathecal administration of etanercept was no more effective than intrathecal treatment alone. These data imply that TNF provides the trigger for phosphorylation of p38 in both DRG neurons and spinal microglia...
  18. ncbi Spinal neurons that possess the substance P receptor are required for the development of central sensitization
    Sergey G Khasabov
    Department of Preventive Sciences, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 22:9086-98. 2002
    ..It appears that this relatively small population of neurons can regulate the physiological properties of other nociceptive neurons and drive central sensitization...
  19. pmc An efficient intrathecal delivery of small interfering RNA to the spinal cord and peripheral neurons
    Miaw Chyi Luo
    Department of Pharmacology, The University of Arizona Health Sciences Center, Tucson, AZ 85724, USA
    Mol Pain 1:29. 2005
    ..The low effective dose of siRNA/i-Fect complex reflects an efficient delivery of the siRNA to peripheral and spinal neurons, produced no behavioral signs of toxicity. This delivery method may be optimized for other gene targets...
  20. ncbi Spinal distribution and metabolism of 2'-O-(2-methoxyethyl)-modified oligonucleotides after intrathecal administration in rats
    M Butler
    Isis Pharmaceuticals, 2292 Faraday Avenue, Carlsbad, CA 92008, USA
    Neuroscience 131:705-15. 2005
    ..ASO are able to reach DRG after IT delivery; however, higher doses may be required to reduce target gene in DRG as compared with spinal cord...
  21. ncbi Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain
    Carsten K Nielsen
    School of Pharmacy, The University of Queensland, Brisbane, QLD, Australia
    Pain 118:112-24. 2005
    ..Xen2174 appears to be a promising candidate for development as a novel therapeutic for i.t. administration to patients with persistent neuropathic pain...
  22. ncbi Diagnostic cerebrospinal fluid examination in children with acute lymphoblastic leukemia: significance of low leukocyte counts with blasts or traumatic lumbar puncture
    Britta Bürger
    Department of Pediatric Hematology Oncology, Hannover Medical School, Hannover, Germany
    J Clin Oncol 21:184-8. 2003
    ..To determine the significance of leukemic blasts or traumatic lumbar puncture (TLP) in diagnostic CSF of children enrolled in the Berlin-Frankfurt-Münster (BFM) Acute Lymphoblastic Leukemia-BFM-95 trial...
  23. pmc Spinal gabapentin and antinociception: mechanisms of action
    Myung Ha Yoon
    Department of Anesthesiology and Pain Medicine, Chonnam National University, Medical School, Gwangju, Korea
    J Korean Med Sci 18:255-61. 2003
    ....
  24. ncbi Intrathecal substance p-saporin attenuates operant escape from nociceptive thermal stimuli
    C J Vierck
    Department of Neuroscience and McKnight Brain Institute, University of Florida College of Medicine, P O Box 100244, Gainesville, FL 32610, USA
    Neuroscience 119:223-32. 2003
    ....
  25. ncbi Phase II, open-label, multicenter study of combined intrathecal morphine and ziconotide: addition of ziconotide in patients receiving intrathecal morphine for severe chronic pain
    Mark S Wallace
    University of California, San Diego School of Medicine, La Jolla, California, USA
    Pain Med 9:271-81. 2008
    ..To assess the safety and efficacy of adding intrathecal ziconotide to intrathecal morphine in patients being treated with a stable intrathecal morphine dose...
  26. ncbi The use of intrathecal midazolam in humans: a case study of process
    Tony L Yaksh
    Department of Anesthesiology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0818, USA
    Anesth Analg 98:1536-45, table of contents. 2004
    ..Issues that are of continuing relevance to the use of intrathecal midazolam, including issues of formulation and kinetics, are considered...
  27. ncbi Interaction between intrathecal morphine and glutamate receptor antagonists in formalin test
    T Nishiyama
    Department of Anesthesiology, The University of Tokyo, Japan
    Eur J Pharmacol 395:203-10. 2000
    ..Spinal mu-opioid receptor activation and NMDA or AMPA receptor antagonism showed a synergistic antinociception against tonic pain. These results suggest an important direction in the management of inflammatory pain...
  28. ncbi Capacity of the clinical picture to characterize low back pain relieved by facet joint anesthesia. Proposed criteria to identify patients with painful facet joints
    M Revel
    , , Paris, France
    Spine (Phila Pa 1976) 23:1972-6; discussion 1977. 1998
    ..These characteristics should not, however, be considered as definite diagnostic criteria of lower back pain originating from facet joints...
  29. ncbi Evidence that gabapentin reduces neuropathic pain by inhibiting the spinal release of glutamate
    Terence J Coderre
    Departments of Anesthesia, Neurology and Neurosurgery and Psychology, McGill University, Montreal, Canada
    J Neurochem 94:1131-9. 2005
    ..t. gabapentin reduces the enhanced noxious stimulus-induced spinal release of glutamate seen in neuropathic rats. These data suggest that gabapentin reduces neuropathic pain symptoms by inhibiting the release of glutamate in the SCDH...
  30. ncbi Intrathecal HIV-1 envelope glycoprotein gp120 induces enhanced pain states mediated by spinal cord proinflammatory cytokines
    E D Milligan
    Department of Psychology and the Center for Neuroscience, University of Colorado, Boulder, Colorado 80309 0345, USA
    J Neurosci 21:2808-19. 2001
    ..These results support the concept that activated glia in dorsal spinal cord can create exaggerated pain states via the release of proinflammatory cytokines...
  31. ncbi Antiallodynic effect of intrathecal gabapentin and its interaction with clonidine in a rat model of postoperative pain
    J K Cheng
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Anesthesiology 92:1126-31. 2000
    ....
  32. ncbi Differential roles of neuronal and endothelial nitric oxide synthases during carrageenan-induced inflammatory hyperalgesia
    F Tao
    Department of Anesthesiology, Johns Hopkins University School of Medicine, 600 North Wolfe Street Blalock 1415, Baltimore, MD 21287, USA
    Neuroscience 128:421-30. 2004
    ..Our current results indicate that nNOS plays different roles in the two phases of carrageenan-induced inflammatory pain. In this model, enhanced spinal eNOS appears to compensate for the role of nNOS in nNOS knockout mice...
  33. ncbi Antinociception with intrathecal alpha-methyl-5-hydroxytryptamine, a 5-hydroxytryptamine 2A/2C receptor agonist, in two rat models of sustained pain
    Masayuki Sasaki
    Department of Anesthesiology and Reanimatology, Gunma University School of Medicine, 3 39 22 Showa machi, Maebashi 371 8511, Japan
    Anesth Analg 96:1072-8, table of contents. 2003
    ..These findings suggest that spinal 5-HT(2A/2C) receptors mediate antinociception in inflammatory pain and neuropathic pain, and the muscarinic receptors contribute to this action...
  34. ncbi Peripheral and central activation of nitric oxide-cyclic GMP pathway by sildenafil
    Chandrashekhar S Patil
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160 014, India
    Inflammopharmacology 13:467-78. 2005
    ..PDE-5 inhibitors could be considered as a new class of anti-nociceptive agents for future drug development...
  35. ncbi Management of chronic low back pain: rationales, principles, and targets of imaging-guided spinal injections
    Jan Fritz
    Department of Diagnostic Radiology, Eberhard Karls University, Hoppe Seyler Str 3, Tubingen, Germany
    Radiographics 27:1751-71. 2007
    ..Diagnostic spinal injections performed in conjunction with imaging may be necessary to test the hypothesis that a particular structure is ..
  36. ncbi Controlling pathological pain by adenovirally driven spinal production of the anti-inflammatory cytokine, interleukin-10
    Erin D Milligan
    Department of Psychology and the Center for Neuroscience, University of CO at Boulder, Boulder, CO 80309, USA
    Eur J Neurosci 21:2136-48. 2005
    ..These studies support that this gene therapy approach provides an alternative to neuronally focused drug and gene therapies for clinical pain control...
  37. ncbi Repeated intrathecal injections of plasmid DNA encoding interleukin-10 produce prolonged reversal of neuropathic pain
    Erin D Milligan
    Department of Psychology and the Center for Neuroscience, University of CO at Boulder, Boulder, CO 80309, USA
    Pain 126:294-308. 2006
    ..Together, these data suggest that intrathecal IL-10 gene therapy may provide a novel approach for prolonged clinical pain control...
  38. ncbi Inhibition of spinal protein kinase C reduces nerve injury-induced tactile allodynia in neuropathic rats
    X Y Hua
    Department of Anesthesiology, University of California, San Diego, La Jolla 92093 0818, USA
    Neurosci Lett 276:99-102. 1999
    ..These data emphasize that spinal PKC plays an important role in nerve injury-induced tactile allodynia. Other protein kinases such as PKA may also contribute to this phenomenon...
  39. ncbi Efficacy and safety of repeated intrathecal triamcinolone acetonide application in progressive multiple sclerosis patients
    Volker Hoffmann
    Department of Neurology, St Josef Hospital, Ruhr University of Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    J Neurol Sci 211:81-4. 2003
    ..No serious side effects occurred. We conclude that repeated intrathecal TCA injection provides substantial benefit for progressive MS patients with predominantly spinal symptoms...
  40. ncbi Effect of diabetes on the mechanisms of intrathecal antinociception of sildenafil in rats
    Claudia Ivonne Araiza-Saldaña
    Departamento de Farmacobiologia, Centro de Investigación y de Estudios Avanzados Coapa, Calzada de los Tenorios 235, Colonia Granjas Coapa, 14330 Mexico, D F, Mexico
    Eur J Pharmacol 527:60-70. 2005
    ..Data suggest that diabetes leads to a dysfunction in NO and large-conductance Ca2+-activated K+ channels. Sildenafil could have a role in the pharmacotherapy of diabetes-associated pain...
  41. ncbi Unintentional vascular uptake in fluoroscopically guided, contrast-confirmed spinal injections: a 1-yr clinical experience and discussion of findings
    Michael F Stretanski
    Department of Neurosciences, Surgical Neurology of North Central Ohio, MedCentral Hospital Mansfield, Mansfield, OH, USA
    Am J Phys Med Rehabil 84:30-5. 2005
    ..Documentation of vascular uptake on spinal injection in the context of negative aspiration and negative passive filling of blood into the hub of the needle...
  42. ncbi A randomized, double-blind, placebo-controlled study of intrathecal ziconotide in adults with severe chronic pain
    Richard L Rauck
    Wake Forest University School of Medicine, The Center for Clinical Research, Carolinas Pain Institute, Winston Salem, North Carolina 27103, USA
    J Pain Symptom Manage 31:393-406. 2006
    ..Slow titration of ziconotide, a nonopioid analgesic, to a low maximum dose resulted in significant improvement in pain and was better tolerated than in two previous controlled trials that used a faster titration to a higher mean dose...
  43. ncbi Polyanalgesic Consensus Conference 2003: an update on the management of pain by intraspinal drug delivery-- report of an expert panel
    Samuel J Hassenbusch
    Department of Neurosurgery, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    J Pain Symptom Manage 27:540-63. 2004
    ..Based on the best available evidence and expert opinion, consensus recommendations were developed in all these areas. The panel's conclusions may provide a foundation for clinical practice and a rational basis for new research...
  44. ncbi Delayed presentation of septic arthritis of a lumbar facet joint after diagnostic facet joint injection
    Neil M Orpen
    Department of Trauma and Orthopaedics, Wycombe General Hospital, High Wycombe, UK
    J Spinal Disord Tech 16:285-7. 2003
    ..We propose that this diagnosis be considered in patients who have undergone diagnostic facet joint injection who subsequently deteriorate with back and leg pain without another apparent cause...
  45. ncbi Safety evaluation of intrathecal substance P-saporin, a targeted neurotoxin, in dogs
    Jeffrey W Allen
    Department of Anesthesiology, University of California, San Diego, La Jolla, California 92093 0818, USA
    Toxicol Sci 91:286-98. 2006
    ..These data indicate no adverse toxicity at doses up to 10 times those necessary for producing loss of superficial NK1r-bearing neurons in a large animal model...
  46. ncbi Intrathecal gadolinium (gadopentetate dimeglumine)-enhanced MR cisternography used to determine potential communication between the cerebrospinal fluid pathways and intracranial arachnoid cysts
    E Turgut Tali
    Department of Radiology, Division of Neuroradiology, Gazi University School of Medicine, 06510 Ankara, Turkey
    Neuroradiology 46:744-54. 2004
    ..In the future, this may have bearing on the selection for surgery of patients with intracranial arachnoid cysts presenting with clinical signs and symptoms potentially related to the location and mass effect of the cyst...
  47. ncbi Intrathecal morphine for off-pump coronary artery bypass grafting
    Samuel Metz
    Department of Anesthesiology, Drexel University College of Medicine, Philadelphia, PA, USA
    J Cardiothorac Vasc Anesth 18:451-3. 2004
    ..To determine if preinduction intrathecal morphine is associated with successful intraoperative extubation in patients undergoing off-pump coronary artery bypass grafting...
  48. ncbi Intact carrageenan-induced thermal hyperalgesia in mice lacking inducible nitric oxide synthase
    F Tao
    Department of Anesthesiology and Critical Care Medicine, Blalock 1415, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287 4965, USA
    Neuroscience 120:847-54. 2003
    ..This suggests that iNOS may be sufficient, but not essential, for the late phase of the carrageenan-induced thermal hyperalgesia...
  49. ncbi Involvement of oxytocin in spinal antinociception in rats with inflammation
    Shuang Quan Yu
    Neurobiology Laboratory, College of Life Sciences, and Center for Brain and Cognitive Science and National Laboratory of Biomembrane and Membrane Biotechnology, Peking University, 100871, Beijing, China
    Brain Res 983:13-22. 2003
    ..The present study showed that both exogenous and endogenous oxytocin displayed antinociception in the spinal cord in rats with inflammation, and mu- and kappa-receptors were involved in oxytocin-induced antinociception...
  50. ncbi Clinical application of adenosine and ATP for pain control
    Masakazu Hayashida
    Surgical Center Research Hospital, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shiroganedai, Minato ku, Tokyo, 108 8639, Japan
    J Anesth 19:225-35. 2005
    ..Thus, adenosine compounds have significant potential for alleviating various types of pain...
  51. ncbi Increased expression of cyclooxygenase and nitric oxide isoforms, and exaggerated sensitivity to prostaglandin E2, in the rat lumbar spinal cord 3 days after L5-L6 spinal nerve ligation
    Darren D O'Rielly
    Division of Basic Medical Sciences, Faculty of Medicine, School of Pharmacy, Memorial University of Newfoundland, St John s, Newfoundland A1B 3V6, Canada
    Anesthesiology 104:328-37. 2006
    ....
  52. ncbi Preemptive effects of intrathecal cyclooxygenase inhibitor or nitric oxide synthase inhibitor on thermal hypersensitivity following peripheral nerve injury
    Ping Wing Lui
    Department of Anesthesiology, Chang Gung Memorial Hospital and Chang Gung University, Linkou, Taiwan
    Life Sci 75:2527-38. 2004
    ..These results demonstrated that intrathecally administered COX inhibitor or NOS inhibitor provides preemptive analgesia on thermal hypersensitivity following chronic constrictive nerve injury in rats...
  53. ncbi Intrathecal gene transfer by adeno-associated virus for pain
    Andreas S Beutler
    Mount Sinai School of Medicine, Department of Medicine, Division of Hematology Oncology, New York, NY 10029, USA
    Curr Opin Mol Ther 7:431-9. 2005
    ..AAV vectors may therefore become an important tool for translational studies to validate newly identified therapeutic targets in clinical pain states...
  54. ncbi Morphine can enhance the antiallodynic effect of intrathecal R-PIA in rats with nerve ligation injury
    Jai Hyun Hwang
    Department of Anesthesia and Pain Medicine, University of Ulsan, College of Medicine, Asan Medical Center, 388 1 Pungnap dong, Songpa Gu, Seoul 138 736, Korea
    Anesth Analg 100:461-8. 2005
    ..These results suggest that activation of mu-opioid and A1 receptors at the spinal level is required for the synergistic interaction on tactile allodynia...
  55. ncbi Efficacy of intrathecal adenosine for postoperative pain relief
    M Sharma
    Department of Anaesthesiology and Critical Care, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India
    Eur J Anaesthesiol 23:449-53. 2006
    ..The aim of the present study was to evaluate the efficacy of intrathecal adenosine for postoperative pain relief, and to determine its role for pre-emptive analgesia...
  56. pmc Regulation of peripheral inflammation by spinal p38 MAP kinase in rats
    David L Boyle
    Division of Rheumatology, Allergy, and Immunology, University of California San Diego School of Medicine, La Jolla, California, United States of America
    PLoS Med 3:e338. 2006
    ..We therefore determined whether these pathways also regulate peripheral inflammation in rat adjuvant arthritis, which is a model of rheumatoid arthritis...
  57. ncbi Differential activation of extracellular signal-regulated protein kinase in primary afferent neurons regulates brain-derived neurotrophic factor expression after peripheral inflammation and nerve injury
    Koichi Obata
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, Nishinomiya, Hyogo 663 8501, Japan
    J Neurosci 23:4117-26. 2003
    ..These changes, including the changes in BDNF expression, might be involved in the pathophysiological changes in primary afferent neurons...
  58. pmc Perispinal etanercept: potential as an Alzheimer therapeutic
    W Sue T Griffin
    Geriatric Research, Education and Clinical Center, Neurobiology, Physiology, and Psychiatry, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Neuroinflammation 5:3. 2008
    ....
  59. ncbi Perispinal etanercept for treatment of Alzheimer's disease
    Edward Tobinick
    100 UCLA Medical Plaza, Suites 205 210, Los Angeles, California 90095, USA
    Curr Alzheimer Res 4:550-2. 2007
    ....
  60. ncbi The involvement of the tetrodotoxin-resistant sodium channel Na(v)1.8 (PN3/SNS) in a rat model of visceral pain
    N Yoshimura
    Departments of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 21:8690-6. 2001
    ..These channels represent a new target for the treatment of inflammatory pain from visceral organs such as the urinary bladder...
  61. ncbi Open-label, multicenter study of combined intrathecal morphine and ziconotide: addition of morphine in patients receiving ziconotide for severe chronic pain
    Lynn R Webster
    Lifetree Clinical Research and Pain Clinic, Salt Lake City, Utah, USA
    Pain Med 9:282-90. 2008
    ..To assess the safety and efficacy of adding intrathecal morphine to intrathecal ziconotide in patients treated with stable ziconotide doses...
  62. ncbi Effect of ketamine on spinal cord nociceptive transmission in normal and monoarthritic rats
    C Laurido
    Department of Biological Sciences, Faculty of Chemistry and Biology, University of Santiago of Chile
    Neuroreport 12:1551-4. 2001
    ....
  63. ncbi The combined effects of N-type calcium channel blockers and morphine on A delta versus C fiber mediated nociception
    V Pirec
    Department of Psychiatry, University of Illinois at Chicago College of Medicine, Chicago, Illinois, USA
    Anesth Analg 92:239-43. 2001
    ....
  64. ncbi Intermittent lumbar puncture in rats: a novel method for the experimental study of opioid tolerance
    Jijun J Xu
    Department of Anesthesiology and Molecular Genetics, Program in Genes and Development, Graduate School of Biomedical Sciences, University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    Anesth Analg 103:714-20. 2006
    ..Intermittent lumbar puncture should prove to be a useful technique for investigating mechanisms of spinal opioid analgesia and opioid tolerance development...
  65. ncbi Marked enhancement of anti-allodynic effect by combined intrathecal administration of the adenosine A1-receptor agonist R-phenylisopropyladenosine and morphine in a rat model of central pain
    M von Heijne
    Karolinska Institutet, Pediatric Anesthesia and Intensive Care, Astrid Lindgren Children s Hospital, Karolinska Hospital, Stockholm, Sweden
    Acta Anaesthesiol Scand 44:665-71. 2000
    ..In the present study, we set out to investigate the possible interaction between i.t. R-PIA and morphine in spinally injured rats...
  66. pmc Inhibition of spinal cytosolic phospholipase A(2) expression by an antisense oligonucleotide attenuates tissue injury-induced hyperalgesia
    D H Kim
    Department of Anesthesiology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0818, USA
    Neuroscience 154:1077-87. 2008
    ..e. second phase flinching behavior), which reflects spinal sensitization. Thus the present findings suggest that cPLA(2)IVA may specifically participate in spinal nociceptive processing...
  67. ncbi Adenosine receptor activation suppresses tactile hypersensitivity and potentiates spinal cord stimulation in mononeuropathic rats
    J G Cui
    Department of Neurosurgery, Karolinska Institute Hospital, Stockholm, Sweden
    Neurosci Lett 223:173-6. 1997
    ..In conclusion, adenosine receptor stimulation antagonizes tactile hypersensitivity in a CCI model of mononeuropathy and potentiates the action of spinal cord stimulation...
  68. ncbi Intrathecal drug therapy for long-term pain management
    Virginia L Ghafoor
    Pain Management, Pharmacy Department, University of Minnesota Medical Center UMMC, Minneapolis 55454, USA
    Am J Health Syst Pharm 64:2447-61. 2007
    ..The use, safety, and efficacy of intrathecal medication administration with implantable pumps for cancer and chronic pain management are reviewed...
  69. ncbi Toward optimal use of intrathecal liposomal cytarabine
    Ching Hon Pui
    Department of Oncology, St Jude Children s Research Hospital, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA
    Leuk Lymphoma 48:1672-3. 2007
  70. ncbi Long-term intrathecal ziconotide for chronic pain: an open-label study
    Lynn R Webster
    Lifetree Clinical Research and Pain Clinic, Salt Lake City, Utah, USA
    J Pain Symptom Manage 37:363-72. 2009
    ..Long-term treatment with ziconotide appeared to be well tolerated and effective in patients whose response to ziconotide and ability to tolerate the drug had been previously demonstrated...
  71. ncbi Results of compassionate therapy with intrathecal depot liposomal cytarabine in acute myeloid leukemia meningeosis
    Juan Manuel Sancho
    Hematology Department, Institut Català d Oncologia Hospital Germans Trias i Pujol, Universitat Autonoma de Barcelona, Badalona, Spain PETHEMA Group, Spanish Society of Hematology, Spain
    Int J Hematol 86:33-6. 2007
    ..Systemic therapy was given concomitantly in all cases, with high-dose cytarabine in 6. Clinical trials should establish the role of IT liposomal cytarabine in leukemic meningitis...
  72. ncbi Intrathecal morphine and clonidine for coronary artery bypass grafting
    P Lena
    Institut Arnault Tzanck, Saint Laurent du Var, Nice, France
    Br J Anaesth 90:300-3. 2003
    ..After cardiac surgery adequate postoperative analgesia is necessary. We assessed analgesia using intrathecal morphine and clonidine...
  73. doi Overdosage of intrathecal gadolinium and neurological response
    L Li
    Department of Neurology, First Affiliated Hospital, Sun Yat Sen University, Guangzhou City, Guangdong Province, China
    Clin Radiol 63:1063-8. 2008
  74. ncbi Phase I safety assessment of intrathecal ketorolac
    James C Eisenach
    Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1009, USA
    Pain 99:599-604. 2002
    ..There were no long-term side effects 6 months after study. These data suggest that intrathecal ketorolac does not produce a high incidence of serious adverse events, and they support further investigation for analgesia...
  75. ncbi Feasibility and toxicity of intrathecal liposomal cytarabine in 5 children and young adults with refractory neoplastic meningitis
    Martin Benesch
    Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Austria
    J Pediatr Hematol Oncol 29:222-6. 2007
    ..IT liposomal cytarabine should, therefore, be used cautiously, if a patient receives other potentially neurotoxic drugs simultaneously...
  76. ncbi Gadolinium encephalopathy due to accidental intrathecal administration of gadopentetate dimeglumine
    Sönke Arlt
    J Neurol 254:810-2. 2007
  77. ncbi Regulation of peripheral inflammation by spinal adenosine: role of somatic afferent fibers
    Linda S Sorkin
    Department of Anesthesiology, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Exp Neurol 184:162-8. 2003
    ..Information on pain and inflammation in the periphery is transmitted to the nervous system, where increased spinal adenosine levels can suppress peripheral inflammation...
  78. ncbi The role of systemic, spinal and supraspinal L-arginine-nitric oxide-cGMP pathway in thermal hyperalgesia caused by intrathecal injection of glutamate in mice
    J Ferreira
    Department of Pharmacology, CCB, Universidade Federal de Santa Catarina, Florianopolis, Brazil
    Neuropharmacology 38:835-42. 1999
    ..t. injection of glutamate into the spinal cord of mice produces dose-related hyperalgesia an effect that was largely mediated by the L-arginine-nitric oxide-cGMP pathway from both spinal and supraspinal sites...
  79. ncbi Role of spinal NO in antiallodynic effect of intrathecal clonidine in neuropathic rats
    H L Pan
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    Anesthesiology 89:1518-23. 1998
    ..The objectives of this study were to assess the role of spinal NO in maintenance of allodynia and to determine the role of spinal NO in the antiallodynic effect of intrathecal clonidine...
  80. ncbi Propentofylline, a glial modulating agent, exhibits antiallodynic properties in a rat model of neuropathic pain
    S M Sweitzer
    Department of Pharmacology and Toxicology, Dartmouth College, Hanover, New Hampshire, USA
    J Pharmacol Exp Ther 297:1210-7. 2001
    ....
  81. ncbi Chronic intrathecal infusions after spinal cord injury cause scarring and compression
    L L Jones
    Department of Neurosciences, University of California-San Diego, La Jolla, California 92093, USA
    Microsc Res Tech 54:317-24. 2001
    ..Future rodent studies using intrathecal infusions should include rigorous evaluation of infusion efficiency and possible secondary tissue damage...
  82. ncbi Analgesic mechanisms of ketamine in the presence and absence of peripheral inflammation
    T Kawamata
    Department of Anesthesiology, Sapporo Medical University School of Medicine, Japan
    Anesthesiology 93:520-8. 2000
    ..In this study, the authors investigated the contribution of supraspinal monoaminergic descending inhibitory system to ketamine analgesia for acute nociception and inflammation-induced hyperalgesia...
  83. ncbi Compassionate use of intrathecal depot liposomal cytarabine as treatment of central nervous system involvement in acute leukemia: report of 6 cases
    Juan Manuel Sancho
    Hematology Department, Institut Català d Oncologia Hospital Germans Trias i Pujol, Badalona
    Haematologica 91:ECR02. 2006
    ..The side effects were mild and manageable in all patients. These findings justify the development of clinical trials to evaluate the efficacy and safety of IT depot cytarabine in meningeal involvement of AL...
  84. ncbi Characteristic of interactions between intrathecal gabapentin and either clonidine or neostigmine in the formalin test
    Myung Ha Yoon
    Department of Anesthesiology and Pain Medicine, Chonnam National University, Medical School, Gwangju, Korea
    Anesth Analg 98:1374-9, table of contents. 2004
    ..We conclude that the combination of gabapentin with either clonidine or neostigmine at the level of the spinal cord could play a major role not only in acute pain, but also in phase 2 of the formalin response...
  85. ncbi Effect of intrathecal octreotide on thermal hyperalgesia and evoked spinal c-Fos expression in rats with sciatic constriction injury
    Yu Chuan Tsai
    Department of Anesthesiology, National Cheng Kung University Medical Center, 138 Sheng Li Road, Tainan 704, Taiwan
    Pain 99:407-13. 2002
    ..This implies that intrathecal sandostatin was effective in the treatment of neuropathic pain...
  86. ncbi Re: Neurologic complications associated with intrathecal liposomal cytarabine given prophylactically in combination with high-dose methotrexate and cytarabine to patients with acute lymphocytic leukemia
    Marc C Chamberlain
    Blood 110:1698; author reply 1698-9. 2007
  87. ncbi Central glucocorticoid receptors modulate the expression of spinal cannabinoid receptors induced by chronic morphine exposure
    Grewo Lim
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, Boston, MA 02114, USA
    Brain Res 1059:20-7. 2005
    ..These results indicate that the expression of spinal CBRs was altered following repeated morphine exposure and regulated by the activation of central GRs...
  88. ncbi Antinociceptive effects and synergistic interaction with morphine of intrathecal metabotropic glutamate receptor 2/3 antagonist in the formalin test of rats
    Myung Ha Yoon
    Department of Anesthesiology and Pain Medicine, Chonnam National University, Medical School, 8 Hakdong, Dongku, Gwangju 501 757, Korea
    Neurosci Lett 394:222-6. 2006
    ..LY341495 and morphine also showed synergistic drug interaction for antinociception during phase 2 in the formalin test...
  89. ncbi Spinal GABA(A) and GABA(B) receptor pharmacology in a rat model of neuropathic pain
    T Philip Malan
    Department of Anesthesiology, The University of Arizona, Tucson, Arizona 85724 5114, USA
    Anesthesiology 96:1161-7. 2002
    ..This study tests the hypothesis that loss of spinal activity of gamma-aminobutyric acid (GABA) contributes to the allodynia and hyperalgesia observed after peripheral nerve injury...
  90. ncbi Ketorolac prevents recurrent withdrawal induced hyperalgesia but does not inhibit tolerance to spinal morphine in the rat
    Stuart A Dunbar
    Department of Anesthesiology, Pain Management Center, Baystate Medical Center, Tufts University, 3400 Main Street, Springfield, MA 01199, USA
    Eur J Pain 11:1-6. 2007
    ....
  91. ncbi Intrathecal minocycline attenuates peripheral inflammation-induced hyperalgesia by inhibiting p38 MAPK in spinal microglia
    Xiao Ying Hua
    Department of Anaesthesiology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0818, USA
    Eur J Neurosci 22:2431-40. 2005
    ....
  92. ncbi Inhibition of acute nociceptive responses in rat spinal cord by a bradykinin B1 receptor antagonist
    Rachel K Conley
    Merck Sharp and Dohme, In Vivo Neuroscience Department, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex, CM20 2QR, UK
    Eur J Pharmacol 527:44-51. 2005
    ..These data show that the antinociceptive effects of a bradykinin B1 receptor antagonist are mediated, at least in part, at the level of the spinal cord and suggest a role for spinal bradykinin B1 receptors in acute nociception...
  93. ncbi Oral gabapentin activates spinal cholinergic circuits to reduce hypersensitivity after peripheral nerve injury and interacts synergistically with oral donepezil
    Ken ichiro Hayashida
    Department of Anesthesiology and Center for Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Winston Salem, NC 27157 1009, USA
    Anesthesiology 106:1213-9. 2007
    ....
  94. ncbi Role of spinal metabotropic glutamate receptor subtype 5 in the development of tolerance to morphine-induced antinociception in rat
    Tao Xu
    Department of Anesthesiology, Shanghai Sixth People s Hospital, Shanghai Jiaotong University, Shanghai 200233, China
    Neurosci Lett 420:155-9. 2007
    ..We conclude that mGluR5 contributes to the development of tolerance to morphine-induced antinociception after chronic morphine exposure...
  95. pmc Augmentation of spinal morphine analgesia and inhibition of tolerance by low doses of mu- and delta-opioid receptor antagonists
    N S Abul-Husn
    Department of Pharmacology and Toxicology, Queen s University, Kingston, Ontario, Canada
    Br J Pharmacol 151:877-87. 2007
    ....
  96. ncbi Intrathecal administration of Cav3.2 and Cav3.3 antisense oligonucleotide reverses tactile allodynia and thermal hyperalgesia in rats following chronic compression of dorsal root of ganglion
    Xian jie Wen
    Department of Anesthesiology, the First Peopleos Hospital of FoShan and Affiliated FoShan Hospital of Sun Yat Sen University, Foshan 528000, China
    Acta Pharmacol Sin 27:1547-52. 2006
    ..The present study aimed to elucidate the role of T-subtype calcium channels (Cav3.1, Cav3.2, and Cav3.3) in the pathogenesis of neuropathic pain at spinal level...
  97. ncbi Changes in G proteins genes expression in rat lumbar spinal cord support the inhibitory effect of chronic pain on the development of tolerance to morphine analgesia
    Mohammad Javan
    Department Physiology, School of Medical Sciences, Tarbiat Modarres University, Tehran, Iran
    Neurosci Res 53:250-6. 2005
    ..The increase in G(alpha i/o) genes expression produced by chronic pain may facilitate the opioid signaling pathway and compensate for morphine-induced tolerance...
  98. pmc Systemic morphine produce antinociception mediated by spinal 5-HT7, but not 5-HT1A and 5-HT2 receptors in the spinal cord
    A Dogrul
    Department of Pharmacology, Gülhane Academy of Medicine, Ankara, Turkey
    Br J Pharmacol 149:498-505. 2006
    ..One of the most recently identified subtypes of 5 HT receptor is the 5-HT7 receptor. We aimed to examine the role of spinal 5-HT7 receptors in the antinociceptive effects of systemic morphine...
  99. ncbi Lack of reciprocity between opioid and 5-HT3 receptors for antinociception in rat spinal cord
    Myung Ha Yoon
    Department of Anesthesiology and Pain Medicine, Chonnam National University, Medical School, Gwangju, Korea
    Pharmacology 77:195-202. 2006
    ..Taken together, no reciprocal interaction was noted between 5-HT(3) receptor and opioid receptors at the spinal level. Thus, the 5-HT(3) receptor antagonist may be useful to manage opioid-induced emesis at the spinal level...
  100. ncbi Activation of spinal cholecystokinin and neurokinin-1 receptors is associated with the attenuation of intrathecal morphine analgesia following electroacupuncture stimulation in rats
    Yohji Fukazawa
    Department of Pharmacology, Wakayama Medical University, 811 1 Kimiidera, Wakayama, Wakayama 641 8509, Japan
    J Pharmacol Sci 104:159-66. 2007
    ....
  101. ncbi Sex differences in morphine-induced analgesia of visceral pain are supraspinally and peripherally mediated
    Yaping Ji
    Department of Biomedical Science, University of Maryland, Baltimore, MD 21201, USA
    Am J Physiol Regul Integr Comp Physiol 291:R307-14. 2006
    ..The present study documents a sex difference in morphine analgesia of visceral pain that is both peripherally and supraspinally mediated...

Research Grants68

  1. Characterization of Toxicity with Spinal Opiates
    Tony L Yaksh; Fiscal Year: 2010
    ..The present studies aim to define the mechanisms of granuloma formation and point to specific methods to prevent granuloma formation, which will increase the utility and reduce the risks of this important pain therapy. ..
  2. A Pragmatic Trial of Lumbar Image Reporting with Epidemiology (LIRE)
    Jeffrey G Jarvik; Fiscal Year: 2012
    ..will reduce subsequent diagnostic and therapeutic interventions, including MR and CT, opioid prescriptions, spinal injections and surgery...
  3. Pain Mechanisms and the Development of Analgesics
    Tony Yaksh; Fiscal Year: 2006
    ..g. COX2 inhibitors, GABApentin, ziconotide) and failures (NK1 antagonist). [unreadable] [unreadable] [unreadable]..
  4. Spinal Galanin and its Receptors in Pain Processing
    Tony Yaksh; Fiscal Year: 2005
    ..We believe the outcome of these studies will provide direct evidence for the role played by this spinal peptidergic system in pain and point to the development of novel anti-hyperpathic agents. ..
  5. NEUROBIOLOGY OF PAIN
    Tony Yaksh; Fiscal Year: 2005
    ..The complexity of the problems and the diversity of the training approaches emphasize that the training received by these fellows will provide a broad base of knowledge relevant to wide areas of neurobiology. ..
  6. PAIN EVOKED RELEASE OF AMINO ACIDS AND PROSTANOIDS
    Tony Yaksh; Fiscal Year: 2005
    ....
  7. Ca permeable non-NMDAr: New spinal sensitization pathway
    Linda Sorkin; Fiscal Year: 2005
    ..We propose to investigate the effects of Ca-permeable non-NMDAr activation on ERK and CREB phosphorylation (using Western blots and immunohistochemistry), expression of c-fos and development of hyperalgesia. ..
  8. Evaluation in Primates of Cocaine Esterase for the Treatment of Cocaine Toxicity
    Mei Chuan Ko; Fiscal Year: 2010
    ..Dose-response functions for each enzyme will be obtained repeatedly and blood samples analyzed for titer development so that tolerance to the effects of CocE can be monitored. ..
  9. Annual Meeting of the American Pain Society
    Linda Sorkin; Fiscal Year: 2005
    ..Abstracts will be judged on scientific merit and published in The Journal of Pain. We believe that these awards will encourage meeting attendance by trainees. ..
  10. Cytokine and MAP Kinase Involvement in Neuropathic Pain
    Linda Sorkin; Fiscal Year: 2008
    ..This approach has the potential for avoiding some of the problems that occur with complete inhibition of p38 function. ..
  11. Intrathecal Opioid-Induced Pruritus
    Mei Chuan Ko; Fiscal Year: 2003
    ..These studies would provide a systematic understanding of the pharmacology of intrathecal morphine-induced pruritus in primates and establish the basis for identifying potential therapeutically effective antipruritics. ..
  12. Role of the Amygdala in Opioid Self-administration in Rats with Chronic Pain.
    Thomas Martin; Fiscal Year: 2009
    ....
  13. PEDIATRIC BRAIN TUMOR RESEARCH CENTER
    Susan Blaney; Fiscal Year: 2003
    ..It offers leadership in the development of new agents, in new uses of sophisticated radiotherapy, and in the application of new approaches to brain tumor therapy. ..
  14. SPINAL CORD INJURY, METHYLPREDNISOLONE & P GLYCOPROTEIN
    CHRISTOPHER BERNARDS; Fiscal Year: 2002
    ..4. To determine whether increased spinal cord bioavailability of methylprednisolone decreases secondary damage following spinal cord injury. ..
  15. Intrathecal enzyme therapy for mucopolysaccharidosis I
    Patricia I Dickson; Fiscal Year: 2010
    ..This research investigates intrathecal enzyme therapy for canine MRS I with translation to the first clinical trial of intrathecal enzyme replacement therapy for MRS I patients. ..
  16. OPIOID-INDUCED PAIN SENSITIVITY: CLINICAL DIAGNOSIS AND MANAGEMENT
    Jianren Mao; Fiscal Year: 2010
    ....
  17. RADIODIAGNOSIS & RADIOTHERAPY OF LUNG CANCER METASTASES
    AMIN KASSIS; Fiscal Year: 2004
    ....
  18. AFFERENT PLASTICITY UNDERLYING URETHRAL AND PELVIC PAIN
    Naoki Yoshimura; Fiscal Year: 2010
    ..This is recognized as a high priority in the urologic care of patients with IC/CPPS. ..
  19. Pilot/Phase I Study of Intrathecal Laronidase for Spinal Cord Compression in Muco
    Patricia Dickson; Fiscal Year: 2009
    ..If successful, delivery into the spinal fluid could represent a practical, straightforward method of treating central nervous system disease due to lysosomal storage. ..
  20. Neuropathic Pain Modulation by Cannabinoids
    Jianren Mao; Fiscal Year: 2006
    ..A better understanding of cannabinoid actions in neuropathic pain states could open a new avenue to developing novel pharmacological tools for the improved management of often intractable and debilitating neuropathic pain syndromes. ..
  21. Cellular Mechanisms of Hyperalgesia and Opioid Tolerance
    Jianren Mao; Fiscal Year: 2005
    ....
  22. Glutamate Uptake & the Pathogenesis of Neuropathic Pain
    Jianren Mao; Fiscal Year: 2007
    ..abstract_text> ..
  23. Nasal Delivery of Naltrexone for Treatment of Alcoholism
    Daniel Wermeling; Fiscal Year: 2006
    ..The long-term goal of this work is to develop and commercialize nasal delivered NTX for the treatment of alcoholism. [unreadable] [unreadable] [unreadable]..
  24. Afferent modulation in bladde dysfunction
    Naoki Yoshimura; Fiscal Year: 2007
    ..abstract not provided ..
  25. The Regulatory Role of Spinal Lipoxins in Nociception
    Linda Sorkin; Fiscal Year: 2008
    ..The aim of this proposal is to investigate the role of lipoxins in conditions associated with persistent inflammatory pain. [unreadable] [unreadable] [unreadable]..
  26. Neurophysiology and Biomechanics of Urethra in Stress Urinary Incontinence
    Naoki Yoshimura; Fiscal Year: 2008
    ..This is recognized as a high priority in the urologic/gynecologic care of SUI patients. [unreadable] [unreadable]..
  27. Lower urinary tract dysfunction in Parkinson's disease
    Naoki Yoshimura; Fiscal Year: 2003
    ..This is a high priority in the urologic care of patients with Parkinson's disease. ..
  28. Bladder Pain Gene Therapy with Pro-opiomelanocortin cDNA
    Naoki Yoshimura; Fiscal Year: 2004
    ..This research project is important to provide a solid basis for potential future clinical application. ..
  29. GENE THERAPY FOR LYSOSOMAL STORAGE DISEASE
    Gordon Watson; Fiscal Year: 2002
    ..4) Combine targeted treatments to effect a complete cure. Treatment with different AAV vectors and different modes of administration will be combined to maximize the benefit to the whole organism. ..
  30. OXIDATION OF MACROMOLECULES IN SPINAL CORD INJURY
    Danxia Liu; Fiscal Year: 2001
    ..This will directly test whether free radicals damage neurons by inducing oxidation of major cell components and will provide strategies for therapy. ..
  31. Neurophysiology of Pain from the Uterine Cervix
    Chuanyao Tong; Fiscal Year: 2007
    ....
  32. Dynorphin Modulation of N-Methyl-D-Aspartate (NMDA) Receptor Function
    Robert Caudle; Fiscal Year: 2009
    ..It is hoped that this information will provide a valuable pharmacological target for interrupting dynorphin's participation in post spinal trauma neurodegeneration. ..
  33. Participating Member Institution in NABTC
    Lisa DeAngelis; Fiscal Year: 2008
    ..abstract_text> ..
  34. PERIOPERATIVE PAIN, IMMUNE FUNCTION, AND METASTASIS
    Gayle Page; Fiscal Year: 2001
    ....
  35. Neurobiology of Joint Manipulation Induced Analgesia
    Kathleen Sluka; Fiscal Year: 2003
    ..This information will further assist the clinician in determining the treatment of choice for a particular patient and potentially guide future clinical research. ..
  36. SPINAL RELEASE OF ENDORPHINS BY OPIOIDS
    LEON TSENG; Fiscal Year: 2002
    ..The tail-flick and hot-plate tests will be used to determine antinociceptive responsiveness of mice or/and rats in this research. These studies will provide valuable insight into the cellular mechanisms of mu opioid antinociception. ..
  37. Hindbrain Herniation in Sheep Model of Myelomeningocele
    Cornelia von Koch; Fiscal Year: 2002
    ..Furthermore, we will characterize in lambs gross pathological and axonal pathfinding anomalies usually seen in the human disease. ..
  38. Role of ASIC3 in the etiology of fibromyalgia
    Kathleen A Sluka; Fiscal Year: 2010
    ..These studies could lead to peripherally based therapeutic approaches to control pain without undesirable CMS (central nervous system) side effects, including gene therapy. ..
  39. Role of endogenous opioid peptides in opioid addiction
    LEON TSENG; Fiscal Year: 2005
    ..Attempt will be made to seek if there are correlative relationships among brain sites sensitive to opioids for the production of place preference or place aversion and the releases of opioid peptides and dopatnine. ..
  40. Neurobiology of Musculoskeletal Pain
    Kathleen Sluka; Fiscal Year: 2005
    ..These proposed studies are intended to help in the understanding and thus potential treatment of chronic muscle pain including such conditions as fibromyalgia, myofascial pain and low back pain. ..
  41. Neonatal Pain, Adult Biobehavioral Responses to Stress
    Gayle Page; Fiscal Year: 2005
    ..Findings from these studies will demonstrate possible negative physiologic and behavioral sequelae of repeated painful experiences during neonatal development as well as suggest potential preventive interventions. ..
  42. Ischemic Spasticity: Modulation by GAD65 Gene Delivery
    Martin Marsala; Fiscal Year: 2010
    ....
  43. Neonatal Bladder Inflammation, Opioids, and Adult Bladder Pain
    Alan Randich; Fiscal Year: 2010
    ....
  44. PRODUCTION OF BETA-GLUCURONIDASE FOR MPS VII
    Emil Kakkis; Fiscal Year: 2002
    ..PROPOSED COMMERCIAL APPLICATION: The enzyme and process created from this work can be used to produce enzyme and treat patients suffering from Mucopolysaccharidosis VII, a serious, life-threatening genetic disorder. ..
  45. Persistent Mechanical Hypersensitivity in Rats: Biobehavioral Effects
    Gayle Page; Fiscal Year: 2009
    ..The relevance of the proposed study to human health is the goal to discern what factors (e.g., sleep disruption, biological responses to stress and anxiety) increase one s risk to develop chronic pain. ..
  46. Novel CRF antagonists for inflammation and pain
    MARK LINDNER; Fiscal Year: 2002
    ..Orally active forms of a small molecule CRF receptor would provide a novel therapeutic strategy for indications of acute and chronic inflammation and inflamatory pain. ..
  47. COGNITIVE REMEDIATION FOR CHILDHOOD CANCER SURVIVORS
    Robert Butler; Fiscal Year: 2002
    ..Secondary and exploratory analyses will examine the influences of maternal factors on CRP adherence and effectiveness. ..
  48. Molecular Classification and Therapy of CNS Lymphomas
    James Rubenstein; Fiscal Year: 2008
    ..We will perform gene expression profile analysis of these tumors from diagnostic specimens obtained from a frozen tumor bank to identify a set of genes, which can be used to predict outcome. ..
  49. Molecular mechanisms of Vitex agnus-castus L. in PMS
    Zaijie Jim Wang; Fiscal Year: 2005
    ..Data from the current study will help to improve or develop novel therapies for the treatment of PMS. ..
  50. Impact of gender differences in morphine metabolites.
    Steven Kern; Fiscal Year: 2005
    ..The results of this project will determine gender differences and important pharmacokinetic and pharmacodynamic covariates to aid in appropriate dosing strategies for the most widely prescribed opioid analgesic. ..
  51. Mitoprotective and antioxidant peptides for DM treatment
    Hazel Szeto; Fiscal Year: 2006
    ..abstract_text> ..
  52. Development of Sensory/Pain-Selective Local Anesthetics
    Peter Gerner; Fiscal Year: 2006
    ..abstract_text> ..
  53. Ischemic Paraplegia: Modulation by Stem Cell Implant
    Martin Marsala; Fiscal Year: 2005
    ....
  54. ASTATINE AND IODINE RADIOLABELED MONOCLONAL ANTIBODIES
    Michael Zalutsky; Fiscal Year: 2008
    ..abstract_text> ..
  55. Image Overlay for MRI-Guided Needle Insertions
    JOHN ANTHONY CARRINO; Fiscal Year: 2010
    ..It can also reduce variability among practitioners, facilitate training, and serve as a research validation tool by providing precisely placed minimally invasive percutaneous conduit under MR guidance. ..
  56. Intrathecal Gene Transfer for Chronic Cancer Pain
    ANDREAS BEUTLER; Fiscal Year: 2008
    ....
  57. DYNORPHIN MODULATES CGRP RELEASE VIA PKC
    Zaijie Jim Wang; Fiscal Year: 2003
    ..Frank Porreca and Josephine Lai. This award is consistent with the long-term career goal of the candidate to become an independent investigator contributing to the basic research of pain and opioid pharmacology. ..
  58. 131-1 3F8 FOR LEPTOMENINGEAL CANCERS
    Kim Kramer; Fiscal Year: 2008
    ..This study will be the basis for other regional therapies using radiolabeled-antibodies targeting tumor associated antigens for other CNS malignancies. [unreadable] [unreadable]..
  59. Improved Animal Modeling of Saccular Aneurysms
    David F Kallmes; Fiscal Year: 2010
    ..This program will enhance health by preventing the catastrophic events resulting from spontaneous rupture of intracranial aneurysms. ..
  60. FUNCTIONAL EVOLUTION OF OPIOID RECEPTORS
    Craig Stevens; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  61. SHAM-CONTROLLED TRIAL OF PERCUTANEOUS VERTEBROPLASTY
    David Kallmes; Fiscal Year: 2008
    ..abstract_text> ..
  62. Endogenous Agmatine in Glutamatergic Pain Processing
    CAROLYN FAIRBANKS; Fiscal Year: 2005
    ..Elucidation of the role of the endogenous agmatine during hyperalgesia and allodynia may lead to the development of a novel class of analgesic drugs or the identification of therapeutic targets. ..
  63. Agmatinergic Control of Opioid Tolerance and Drug Abuse
    CAROLYN FAIRBANKS; Fiscal Year: 2003
    ..abstract_text> ..
  64. Genetic and Tissue Engineering for Aneurysms
    David Kallmes; Fiscal Year: 2004
    ..Successful implementation of this research program will advance the field of genetic and tissue engineering and will improve the care of patients harboring life-threatening cerebral aneurysms. ..
  65. Treating CNS malignancies with 131-I-8H9
    Kim Kramer; Fiscal Year: 2006
    ..abstract_text> ..
  66. Early-In-Life Inflammation Effects on Urinary Bladder Sensation
    Alan Randich; Fiscal Year: 2009
    ..Translation to the treatment of painful bladder syndromes like 1C would be highly probable. ..
  67. Effects of early-in-life bladder stimulation on adults
    Alan Randich; Fiscal Year: 2004
    ..Translation to the treatment of IC would be highly probable. ..