intraventricular injections

Summary

Summary: Injections into the cerebral ventricles.

Top Publications

  1. ncbi Role of melanocortin-4 receptors in mediating renal sympathoactivation to leptin and insulin
    Kamal Rahmouni
    Hypertension Genetics Specialized Center of Research, and Department of Internal Medicine, University of Iowa and the Veterans Administration Medical Center, Iowa City, Iowa 52242, USA
    J Neurosci 23:5998-6004. 2003
  2. ncbi Hypothalamic mTOR signaling regulates food intake
    Daniela Cota
    Department of Psychiatry, University of Cincinnati, Genome Research Institute, 2170 East Galbraith Road, Cincinnati, OH 45237, USA
    Science 312:927-30. 2006
  3. pmc A major role for perifornical orexin neurons in the control of glucose metabolism in rats
    Chun Xia Yi
    Department of Hypothalamic Integration Mechanisms, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands
    Diabetes 58:1998-2005. 2009
  4. ncbi Locomotor effects of ethanol and acetaldehyde after peripheral and intraventricular injections in Swiss and C57BL/6J mice
    Sophie Tambour
    Unité de Recherche en Psychologie Expérimentale et Neurosciences Cognitives URPENC, Universite de Liege, Boulevard du Rectorat 5 B32, B 4000 Liege, Belgium
    Behav Brain Res 172:145-54. 2006
  5. ncbi Open field locomotor effects in rats after intraventricular injections of ethanol and the ethanol metabolites acetaldehyde and acetate
    M Correa
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Brain Res Bull 62:197-202. 2003
  6. ncbi Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and Agouti-related protein mRNA levels and body weight in rats
    J Kamegai
    Department of Medicine, Nippon Medical School, Tokyo, Japan
    Diabetes 50:2438-43. 2001
  7. ncbi Role of vagus nerve signaling in CNI-1493-mediated suppression of acute inflammation
    L V Borovikova
    The Picower Institute for Medical Research, Manhasset, NY 11030, USA
    Auton Neurosci 85:141-7. 2000
  8. ncbi Kisspeptin activation of gonadotropin releasing hormone neurons and regulation of KiSS-1 mRNA in the male rat
    Michael S Irwig
    Department of Medicine, University of Washington, Seattle, WA, USA
    Neuroendocrinology 80:264-72. 2004
  9. ncbi Central and peripheral administration of kisspeptin-10 stimulates the hypothalamic-pituitary-gonadal axis
    E L Thompson
    Department of Metabolic Medicine, Imperial College Faculty of Medicine, Hammersmith Campus, Du Cane Road, London W12 0NN, UK
    J Neuroendocrinol 16:850-8. 2004
  10. ncbi Leptin regulation of the anorexic response to glucagon-like peptide-1 receptor stimulation
    Diana L Williams
    University of Washington, Harborview Medical Center, 325 9th Ave, Box 359675, Seattle, WA 98104, USA
    Diabetes 55:3387-93. 2006

Research Grants

Detail Information

Publications198 found, 100 shown here

  1. ncbi Role of melanocortin-4 receptors in mediating renal sympathoactivation to leptin and insulin
    Kamal Rahmouni
    Hypertension Genetics Specialized Center of Research, and Department of Internal Medicine, University of Iowa and the Veterans Administration Medical Center, Iowa City, Iowa 52242, USA
    J Neurosci 23:5998-6004. 2003
    ..In addition, the renal sympathoexcitatory responses to leptin and insulin are dependent on the MC-4R, demonstrating an important role for the MC-4R in the regulation of renal sympathetic nerve outflow by leptin and insulin...
  2. ncbi Hypothalamic mTOR signaling regulates food intake
    Daniela Cota
    Department of Psychiatry, University of Cincinnati, Genome Research Institute, 2170 East Galbraith Road, Cincinnati, OH 45237, USA
    Science 312:927-30. 2006
    ..Thus, mTOR is a cellular fuel sensor whose hypothalamic activity is directly tied to the regulation of energy intake...
  3. pmc A major role for perifornical orexin neurons in the control of glucose metabolism in rats
    Chun Xia Yi
    Department of Hypothalamic Integration Mechanisms, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands
    Diabetes 58:1998-2005. 2009
    ..In the present study, we investigated the role of endogenous hypothalamic orexin release in glucose homeostasis in rats...
  4. ncbi Locomotor effects of ethanol and acetaldehyde after peripheral and intraventricular injections in Swiss and C57BL/6J mice
    Sophie Tambour
    Unité de Recherche en Psychologie Expérimentale et Neurosciences Cognitives URPENC, Universite de Liege, Boulevard du Rectorat 5 B32, B 4000 Liege, Belgium
    Behav Brain Res 172:145-54. 2006
    ..Additionally, the present study shows that the stimulant properties of acetaldehyde, even after direct infusion into the brain, are not as obvious as previously speculated...
  5. ncbi Open field locomotor effects in rats after intraventricular injections of ethanol and the ethanol metabolites acetaldehyde and acetate
    M Correa
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Brain Res Bull 62:197-202. 2003
    ..Moreover, it is possible that some of the motor suppression or sedation produced by ethanol is due to the central actions of acetate...
  6. ncbi Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and Agouti-related protein mRNA levels and body weight in rats
    J Kamegai
    Department of Medicine, Nippon Medical School, Tokyo, Japan
    Diabetes 50:2438-43. 2001
    ..0 +/- 22.5% of saline-treated controls; P < 0.05) in the arcuate nucleus. Thus, the primary hypothalamic targets of ghrelin are NPY/AGRP-containing neurons, and ghrelin is a newly discovered orexigenic peptide in the brain and stomach...
  7. ncbi Role of vagus nerve signaling in CNI-1493-mediated suppression of acute inflammation
    L V Borovikova
    The Picower Institute for Medical Research, Manhasset, NY 11030, USA
    Auton Neurosci 85:141-7. 2000
    ..These results now identify a previously unrecognized role of efferent vagus nerve activity in mediating the central action of an anti-inflammatory agent...
  8. ncbi Kisspeptin activation of gonadotropin releasing hormone neurons and regulation of KiSS-1 mRNA in the male rat
    Michael S Irwig
    Department of Medicine, University of Washington, Seattle, WA, USA
    Neuroendocrinology 80:264-72. 2004
    ....
  9. ncbi Central and peripheral administration of kisspeptin-10 stimulates the hypothalamic-pituitary-gonadal axis
    E L Thompson
    Department of Metabolic Medicine, Imperial College Faculty of Medicine, Hammersmith Campus, Du Cane Road, London W12 0NN, UK
    J Neuroendocrinol 16:850-8. 2004
    ..Kisspeptin therefore potently stimulates the hypothalamic-pituitary-gonadal axis. These effects are likely to be mediated via the hypothalamic LHRH system...
  10. ncbi Leptin regulation of the anorexic response to glucagon-like peptide-1 receptor stimulation
    Diana L Williams
    University of Washington, Harborview Medical Center, 325 9th Ave, Box 359675, Seattle, WA 98104, USA
    Diabetes 55:3387-93. 2006
    ....
  11. ncbi Locomotor stimulant effects of intraventricular injections of low doses of ethanol in rats: acute and repeated administration
    M Correa
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Psychopharmacology (Berl) 170:368-75. 2003
    ..Moreover, chronic ethanol administration fails to produce signs of locomotor sensitization in rats...
  12. ncbi Developmental and hormonally regulated messenger ribonucleic acid expression of KiSS-1 and its putative receptor, GPR54, in rat hypothalamus and potent luteinizing hormone-releasing activity of KiSS-1 peptide
    V M Navarro
    Physiology Section, Department of Cell Biology, Physiology, and Immunology, Faculty of Medicine, University of Cordoba, Avda Menendez Pidal s n, 14004 Cordoba, Spain
    Endocrinology 145:4565-74. 2004
    ..Our current data support the contention that the hypothalamic KiSS-1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood...
  13. ncbi A role for glucagon-like peptide-1 in the central regulation of feeding
    M D Turton
    Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK
    Nature 379:69-72. 1996
    ..Both of these regions of the brain are of primary importance in the regulation of feeding. These findings suggest that central GLP-1 is a new physiological mediator of satiety...
  14. pmc Physiological response to long-term peripheral and central leptin infusion in lean and obese mice
    J L Halaas
    Laboratory of Molecular Genetics, The Rockefeller University, 1230 York Avenue, New York, NY, 10021, USA
    Proc Natl Acad Sci U S A 94:8878-83. 1997
    ..In NZO mice, leptin resistance may be the result of decreased transport of leptin into the cerebrospinal fluid, whereas in Ay mice, leptin resistance probably results from defects downstream of the leptin receptor in the hypothalamus...
  15. pmc Widespread gene delivery and structure-specific patterns of expression in the brain after intraventricular injections of neonatal mice with an adeno-associated virus vector
    M A Passini
    Department of Pathobiology and Center for Comparative Medical Genetics, School of Veterinary Medicine, University of Pennsylvania, and Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Virol 75:12382-92. 2001
    ..This study demonstrates that gene transfer throughout the CNS can be achieved without germ line transmission and establishes an experimental strategy for introducing genes to somatic cells in a highly predictable manner...
  16. ncbi Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats
    Silvana Obici
    Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Nat Neurosci 5:566-72. 2002
    ..Thus, insulin receptors in discrete areas of the hypothalamus have a physiological role in the control of food intake, fat mass and hepatic action of insulin...
  17. ncbi Melatonin reduces blood pressure in rats with stress-induced hypertension via GABAA receptors
    Hua Li Li
    Department of Physiology, Norman Bethune College of Medical Sciences, Jilin University, Changchun, Jilin, China
    Clin Exp Pharmacol Physiol 36:436-40. 2009
    ..The antihypertensive effect of melatonin may be mediated by GABA(A) receptors through inhibition of plasma AngII levels...
  18. ncbi Agouti-related peptide, neuropeptide Y, and somatostatin-producing neurons are targets for ghrelin actions in the rat hypothalamus
    Luisa M Seoane
    Department of Physiology, Faculty of Medicine, University of Santiago de Compostela, 15705 Santiago de Compostela, Spain
    Endocrinology 144:544-51. 2003
    ..This study furthers our understanding of the molecular basis and mechanisms involved in the effect of ghrelin on food intake and GH secretion...
  19. ncbi Blockade of central GLP-1 receptors prevents CART-induced hypophagia and brain c-Fos expression
    Susan Aja
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 618, Baltimore, MD 21205, USA
    Peptides 27:157-64. 2006
    ..These data suggest that i.c.v. CART administration activates a central release of GLP-1 to inhibit feeding and produce widespread neural activation...
  20. ncbi Fourth ventricular injection of CART peptide inhibits short-term sucrose intake in rats
    H Zheng
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
    Brain Res 896:153-6. 2001
    ..02-0.08 nmol) no readily noticeable motor impairments were observed. The results are consistent, but do not prove a site of action within the brainstem, possibly in mediating vagal satiety signals at the level of the NTS...
  21. ncbi Behavioral effects of intraventricular injections of low doses of ethanol, acetaldehyde, and acetate in rats: studies with low and high rate operant schedules
    Maria N Arizzi
    Department of Psychology, University of Connecticut, U 1020, Storrs, CT 06269 1020, USA
    Behav Brain Res 147:203-10. 2003
    ....
  22. ncbi Interactions between the melanocortin system and leptin in control of sympathetic nerve traffic
    W G Haynes
    Hypertension Genetics Specialized Center of Research, Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242, USA
    Hypertension 33:542-7. 1999
    ..Our data also suggest that leptin increases renal SNA through activation of hypothalamic melanocortin receptors. In contrast, sympathoactivation to thermogenic BAT by leptin appears to be independent of the melanocortin system...
  23. pmc Ghrelin induces fasted motor activity of the gastrointestinal tract in conscious fed rats
    Kazunori Fujino
    Department of Surgery, Shiga University of Medical Science, Otsu, Japan
    J Physiol 550:227-40. 2003
    ..The action of ghrelin to induce fasted motor activity is strongly affected by intragastric pH; low pH inhibits the action...
  24. pmc Intracerebroventricular administration of neuropeptide Y induces hepatic insulin resistance via sympathetic innervation
    Anita M van den Hoek
    TNO Quality of Life, Gaubius Laboratory, Leiden, The Netherlands
    Diabetes 57:2304-10. 2008
    ..Therefore, the aim of this study was to establish whether intracerebroventricular NPY administration modulates the suppressive action of insulin on EGP via hepatic sympathetic or parasympathetic innervation...
  25. ncbi Neuromedin U partially mediates leptin-induced hypothalamo-pituitary adrenal (HPA) stimulation and has a physiological role in the regulation of the HPA axis in the rat
    Preeti H Jethwa
    Department of Metabolic Medicine, Imperial College London, London W12 0NN, United Kingdom
    Endocrinology 147:2886-92. 2006
    ..05)]. These studies suggest that NMU may play a role in the regulation of the HPA axis and partially mediate leptin-induced HPA stimulation...
  26. ncbi Central effect of ghrelin, an endogenous growth hormone secretagogue, on hypothalamic peptide gene expression
    J Kamegai
    Department of Medicine, Nippon Medical School, Tokyo, Japan
    Endocrinology 141:4797-800. 2000
    ..Thus, ghrelin has an alternative role in stimulating food intake via an increase of AGRP rather than the release of GH from the pituitary...
  27. ncbi Hypothalamic paraventricular injections of ghrelin: effect on feeding and c-Fos immunoreactivity
    Pawel K Olszewski
    Veterans Affairs Medical Center, 1 Veterans Drive, Research Route 151, Minneapolis, MN 55417, USA
    Peptides 24:919-23. 2003
    ..We conclude that the PVN, as part of larger central circuitry, mediates orexigenic properties of ghrelin...
  28. ncbi Evidence of an orexigenic role for cocaine- and amphetamine-regulated transcript after administration into discrete hypothalamic nuclei
    C R Abbott
    Endocrine Unit, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom W12 ONN
    Endocrinology 142:3457-63. 2001
    ..These data suggest that cocaine- and amphetamine-regulated transcript may play an orexigenic role in the hypothalamic feeding circuitry...
  29. ncbi Intraventricular thrombolysis speeds blood clot resolution: results of a pilot, prospective, randomized, double-blind, controlled trial
    Neal J Naff
    Department of Neurosurgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Neurosurgery 54:577-83; discussion 583-4. 2004
    ..However, this intervention may increase the rates of rebleeding and infection. To assess the safety and efficacy of intraventricular thrombolysis, we conducted a pilot, randomized, double-blind, controlled, multicenter study...
  30. ncbi A C-terminal fragment of Agouti-related protein increases feeding and antagonizes the effect of alpha-melanocyte stimulating hormone in vivo
    M Rossi
    Endocrine Unit, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Endocrinology 139:4428-31. 1998
    ..In conclusion, Agrp(83-132) administered i.c.v. increases feeding with long lasting effects and is able to inhibit the action of alphaMSH. This interaction may be mediated by the MC3-R and/or MC4-R...
  31. ncbi A role for melanin-concentrating hormone in the central regulation of feeding behaviour
    D Qu
    Elliott P Joslin Research Laboratory, Joslin Diabetes Center, Boston, MA, USA
    Nature 380:243-7. 1996
    ..These findings suggest that MCH participates in the hypothalamic regulation of body weight...
  32. ncbi Phosphoinositide hydrolysis in vivo with group I metabotropic glutamate receptor agonists
    M P Johnson
    Neuroscience Department, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Brain Res 821:539-45. 1999
    ..This method could be quite useful in determining the doses and routes of administration of agonists and antagonists that are required to interact with group I mGluRs...
  33. ncbi The role of CNS glucagon-like peptide-1 (7-36) amide receptors in mediating the visceral illness effects of lithium chloride
    R J Seeley
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
    J Neurosci 20:1616-21. 2000
    ..The same dose of GLP-1 receptor antagonist did not reverse the LiCl-induced reduction in NaCl intake. The data indicate a role for GLP-1 receptors in the CNS pathway that mediates some of the effects of visceral illness...
  34. ncbi Central injection of senktide, an NK3 receptor agonist, or neuropeptide Y inhibits LH secretion and induces different patterns of Fos expression in the rat hypothalamus
    Tatiana Sandoval-Guzmán
    Department of Pathology, University of Arizona College of Medicine, Tucson, AZ 85724, USA
    Brain Res 1026:307-12. 2004
    ..These data, combined with the induction of Fos in medial preoptic and arcuate neurons, strongly support the hypothesis that NKB neurons play a role in the regulation of gonadotropin secretion...
  35. ncbi Cross-talk between the insulin and leptin signaling systems in rat hypothalamus
    Jose B C Carvalheira
    Department of Internal Medicine, State University of Campinas UNICAMP, Campinas SP, Brazil
    Obes Res 13:48-57. 2005
    ..To investigate whether insulin and leptin share common intracellular signal transduction pathways and to determine whether these hormonal signaling systems modulate each other's action in rat hypothalamus...
  36. ncbi Behavioral and hippocampal changes after prenatal invasive interventions with possible relevance to schizophrenia
    Ulrich Sprick
    Rheinische Kliniken Düsseldorf, Kliniken der Heinrich Heine Universität Düsseldorf, Bergische Landstr 2, D 40629 Düsseldorf, Germany
    Behav Brain Res 172:179-86. 2006
    ..g., changes at cell level in the hippocampus, perseverative behaviour, lower weight gains), although others (e.g., increased social contacts) did not...
  37. ncbi RGS9 proteins facilitate acute tolerance to mu-opioid effects
    J Garzon
    Neurofarmacologia, Instituto de Neurobiologia Santiago Ramon y Cajal, Consejo Superior de Investigaciones Cientificas, Avenida Doctor Arce 37, E 28002 Madrid, Spain
    Eur J Neurosci 13:801-11. 2001
    ..The desensitization of mu-opioid receptors appears to be a cell membrane-limited process facilitated by RGS9's sequestering of agonist-segregated G alpha subunits...
  38. ncbi The diverse roles of specific GLP-1 receptors in the control of food intake and the response to visceral illness
    Kimberly P Kinzig
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
    J Neurosci 22:10470-6. 2002
    ....
  39. ncbi Central resistin induces hepatic insulin resistance via neuropeptide Y
    Neel S Singhal
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 27:12924-32. 2007
    ..Together, these results suggest that resistin action on NPY neurons is an important regulator of hepatic insulin sensitivity...
  40. ncbi Intraventricular administration of the neurotrophic factor midkine ameliorates hippocampal delayed neuronal death following transient forebrain ischemia in gerbils
    Y Yoshida
    School of Medical Sciences, Faculty of Medicine, Kagoshima University, 8 35 1 Sakuragaoka, 890 8506, Kagoshima, Japan
    Brain Res 894:46-55. 2001
    ..The potent neuroprotective activity of MK observed in vivo suggested that MK might be useful as a therapeutic reagent for prevention of neuronal death in neurodegenerative diseases...
  41. ncbi The rat arcuate nucleus integrates peripheral signals provided by leptin, insulin, and a ghrelin mimetic
    Adrian K Hewson
    Department of Physiology, University of Cambridge, Downing Street, Cambridge CB2 3EG, U K
    Diabetes 51:3412-9. 2002
    ..These data provide evidence that the ghrelin-sensitive circuits in the hypothalamus are dynamically regulated by central insulin and leptin action...
  42. ncbi Targeted disruption of histamine H1-receptor attenuates regulatory effects of leptin on feeding, adiposity, and UCP family in mice
    T Masaki
    Department of Internal Medicine, School of Medicine, Oita Medical University, Hasama, Japan
    Diabetes 50:385-91. 2001
    ..These results show that H1KO mice are a novel leptin-resistant model and that H1-R is a key receptor for downstream signaling of leptin in the brain that contributes to regulation of feeding, fat deposition, and UCP mRNA expression...
  43. ncbi Expression of biologically active rat apolipoprotein AIV in Escherichia coli
    Min Liu
    Department of Pathology, University of Cincinnati School of Medicine, Cincinnati, OH 45267 0529, USA
    Physiol Behav 78:149-55. 2003
    ....
  44. ncbi Oxyntomodulin and glucagon-like peptide-1 differentially regulate murine food intake and energy expenditure
    Laurie L Baggio
    Department of Medicine, Banting and Best Diabetes Centre, Toronto General Hospital, University of Toronto, Ontario, Canada
    Gastroenterology 127:546-58. 2004
    ..The proglucagon-derived peptide (PGDP) oxyntomodulin (OXM) is cosecreted with GLP-1 and inhibits feeding in rodents and humans; however, a distinct receptor for OXM has not been identified...
  45. ncbi Fetal hippocampal grafts containing CA3 cells restore host hippocampal glutamate decarboxylase-positive interneuron numbers in a rat model of temporal lobe epilepsy
    A K Shetty
    Departments of Surgery Neurosurgery and Neurobiology, Duke University Medical Center Durham, North Carolina 27710, USA
    J Neurosci 20:8788-801. 2000
    ..This specific graft-mediated effect is beneficial because reactivation of interneurons could ameliorate both loss of functional inhibition and hyperexcitability in CA3-lesioned hippocampus...
  46. pmc Pituitary adenylate cyclase-activating polypeptide (PACAP) mimics neuroendocrine and behavioral manifestations of stress: Evidence for PKA-mediated expression of the corticotropin-releasing hormone (CRH) gene
    Anika Agarwal
    Tufts New England Medical Center, Boston, MA 02111, USA
    Brain Res Mol Brain Res 138:45-57. 2005
    ..Both in vivo and in vitro data point to the importance of PACAP-mediated activation of the cAMP/PKA signaling pathway for stimulation of CRH gene transcription, likely via the CRE...
  47. ncbi Inhibition of metastin (kisspeptin-54)-GPR54 signaling in the arcuate nucleus-median eminence region during lactation in rats
    S Yamada
    Laboratory of Reproductive Science, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    Endocrinology 148:2226-32. 2007
    ....
  48. ncbi CART peptides in the central control of feeding and interactions with neuropeptide Y
    P D Lambert
    Neuroscience Division, Yerkes Regional Primate Research Center, Atlanta, Georgia 30329, USA
    Synapse 29:293-8. 1998
    ..These data suggest functional interactions between CART peptides and NPY. These results indicate that CART peptides play a role in the control of food intake by the brain...
  49. ncbi Gut hormone PYY(3-36) physiologically inhibits food intake
    Rachel L Batterham
    Imperial College Faculty of Medicine at Hammersmith Campus, Du Cane Road, London W12 0NN, UK
    Nature 418:650-4. 2002
    ..Thus, postprandial elevation of PYY(3-36) may act through the arcuate nucleus Y2R to inhibit feeding in a gut-hypothalamic pathway...
  50. ncbi Exendin-4 potently decreases ghrelin levels in fasting rats
    Diego Perez-Tilve
    Department of Functional Biology and Health Sciences, Faculty of Biology, Laboratory of Endocrinology, Campus of Vigo, As Lagoas Marcosende, University of Vigo, E 36310 Vigo, Spain
    Diabetes 56:143-51. 2007
    ....
  51. pmc Hypothalamic resistin induces hepatic insulin resistance
    Evan D Muse
    Department of Molecular Pharmacology, Albert Einstein College of Medicine of Yeshiva University, New York, NY 10461, USA
    J Clin Invest 117:1670-8. 2007
    ..These results unveil what we believe to be a novel site of action of resistin on GP and inflammation and suggest that hypothalamic resistin action can contribute to hyperglycemia in type 2 diabetes mellitus...
  52. ncbi Intraventricular insulin and leptin reduce food intake and body weight in C57BL/6J mice
    Lynda M Brown
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45237, USA
    Physiol Behav 89:687-91. 2006
    ..Hence, genetic manipulations that influence brain insulin sensitivity in mice can now more easily be integrated with the broader literature on energy homeostasis...
  53. pmc Role of Dickkopf-1, an antagonist of the Wnt/beta-catenin signaling pathway, in estrogen-induced neuroprotection and attenuation of tau phosphorylation
    Quan Guang Zhang
    Developmental Neurobiology Program, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Neurosci 28:8430-41. 2008
    ....
  54. ncbi Cardiovascular effects of centrally administered arachidonic acid in haemorrhage-induced hypotensive rats: investigation of a peripheral mechanism
    Murat Yalcin
    Department of Physiology, Faculty of Veterinary Medicine, Uludag University, Bursa, Turkey
    Clin Exp Pharmacol Physiol 36:447-53. 2009
    ..The observed increases in plasma catecholamine and vasopressin levels, as well as PRA, mediate the pressor response to AA in haemorrhage-induced hypotensive rats...
  55. ncbi Intraventricular injections of tachykinin NK3 receptor agonists suppress the intake of "salty" tastes by sodium deficient rats
    Francis W Flynn
    Department of Zoology and Physiology, Graduate Neuroscience Program, University of Wyoming, Laramie, WY 82071, USA
    Behav Brain Res 166:1-8. 2006
    b>Intraventricular injections of the tachykinin NK3 receptor (NK3-R) agonist, senktide, suppress the ingestion of hypertonic (0.5 M) NaCl by decreasing the initial lick rate and accelerating the decay in lick rate in sodium deficient rats...
  56. ncbi Cohort study of intraventricular thrombolysis with recombinant tissue plasminogen activator for aneurysmal intraventricular hemorrhage
    J Max Findlay
    Division of Neurosurgery, Department of Surgery, Walter Mackenzie Health Science Centre, Edmonton, Alberta, Canada
    Neurosurgery 55:532-7; discussion 537-8. 2004
    ....
  57. ncbi Intracerebroventricular CART peptide reduces food intake and alters motor behavior at a hindbrain site
    S Aja
    Department of Psychiatry, Johns Hopkins University School of Medicine, 720 Rutland Ave, Ross 618, Baltimore, MD 21205
    Am J Physiol Regul Integr Comp Physiol 281:R1862-7. 2001
    ..The association of CART-induced feeding suppression with altered motor behavior questions the specificity of intracerebroventricular CART for actions on feeding...
  58. pmc The type 1 TNF receptor and its associated adapter protein, FAN, are required for TNFalpha-induced sickness behavior
    Karine Palin
    Integrative Immunology and Behavior Program, Laboratory of Integrative Immunophysiology, Department of Animal Sciences, University of Illinois at Urbana Champaign, 227 Edward R Madigan Laboratory, 1201 West Gregory Drive, Urbana, IL 61801 3873, USA
    Psychopharmacology (Berl) 201:549-56. 2009
    ..TNFalpha activates neutral sphingomyelinase through the TNF-R1 adapter protein FAN (factor associated with neutral sphingomyelinase activation), but a behavioral role of FAN in the brain has never been reported...
  59. ncbi Intraventricular hemorrhage after aneurysmal subarachnoid hemorrhage: pilot study of treatment with intraventricular tissue plasminogen activator
    Panayiotis N Varelas
    Department of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Neurosurgery 56:205-13; discussion 205-13. 2005
    ..This prospective study examines the feasibility and outcome of administration of IVen tissue plasminogen activator (tPA) after aneurysmal SAH...
  60. ncbi p38 MAPK mediates cardiovascular and behavioral responses induced by central IL-1 beta and footshock in conscious rats
    Rui Mao Zheng
    Department of Physiology and Pathophysiology, Health Science Center, Peking University, Beijing 100083, China
    Acta Pharmacol Sin 25:266-70. 2004
    ..To investigate the roles of p38 mitogen-activated protein kinase (p38 MAPK) in the cardiovascular and behavioral responses induced by intracerebral ventricular injection (i.c.v.) of interleukin-1 beta (IL-1 beta) or footshock...
  61. ncbi Glucocorticoid modulation of atrial natriuretic peptide, oxytocin, vasopressin and Fos expression in response to osmotic, angiotensinergic and cholinergic stimulation
    F Lauand
    Department of Physiology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Avenida dos Bandeirantes, 3900 Monte Alegre, CEP 14049 900 Ribeirao Preto, SP, Brazil
    Neuroscience 147:247-57. 2007
    ..The present data also suggest that these responses are modulated by glucocorticoids...
  62. ncbi Vasopressin mechanism-mediated pressor responses caused by central angiotensin II in the ovine fetus
    Lijun Shi
    Harbor UCLA Medical Center, 1124 West Carson Street, RB 1, Torrance, CA 90502, USA
    Pediatr Res 56:756-62. 2004
    ..The results suggest that the central Ang II-mediated pressor responses at the last third of gestation is mediated partially by the AVP mechanism via V1 not V2 receptors...
  63. ncbi Ghrelin inhibits sympathetic nervous activity in sepsis
    Rongqian Wu
    The Feinstein Institute for Medical Research, 350 Community Dr, Manhasset, NY 11030, USA
    Am J Physiol Endocrinol Metab 293:E1697-702. 2007
    ..Ghrelin's inhibitory effect on TNF-alpha production in sepsis is partially because of its modulation of the overstimulated sympathetic nerve activation...
  64. ncbi Metabotropic glutamate receptors in the hippocampus and nucleus accumbens are involved in generating seizure-induced hippocampal gamma waves and behavioral hyperactivity
    Jingyi Ma
    Department of Physiology, London Health Sciences Centre, University Campus, The University of Western Ontario, Canada N6A 5A5
    Behav Brain Res 133:45-56. 2002
    ..However, spontaneous gamma and theta waves in the normal hippocampus are not mediated by mGluRs...
  65. ncbi Chronic food restriction increases D-1 dopamine receptor agonist-induced phosphorylation of extracellular signal-regulated kinase 1/2 and cyclic AMP response element-binding protein in caudate-putamen and nucleus accumbens
    S L Haberny
    Department of Pharmacology, New York University School of Medicine, New York, NY 10016, USA
    Neuroscience 125:289-98. 2004
    ..The upregulation of striatal MAP kinase signaling in food-restricted animals may adaptively serve to facilitate associative learning but, at the same time, increase vulnerability to the rewarding and addictive properties of abused drugs...
  66. ncbi Nitric oxide involves in carnosine-induced hyperactivity in chicks
    Shozo Tomonaga
    Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka, Japan
    Eur J Pharmacol 524:84-8. 2005
    ..These results suggest that carnosine-induced hyperactivity may be linked to the constitutive NOS (cNOS), rather than iNOS, in the brain. Central carnosine may regulate brain function and/or behaviors by NO generation via cNOS in chicks...
  67. ncbi Angiotensin-induced vasopressin release and activation of hypothalamic neuron in pre-term fetuses
    Zhice Xu
    Soochaw University School of Medicine, Suzhou 215007, China
    Peptides 26:307-14. 2005
    ..The results suggest that hypothalamic-neurohypophysial system has been relatively intact and functional at 70% gestational age, and that central angiotensin is important in inducing fetal vasopressin release in utero...
  68. ncbi Effect of central administration of carnosine and its constituents on behaviors in chicks
    Shozo Tomonaga
    Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresource and Bioenvironmental Science, Kyushu University, Fukuoka 812 8581, Japan
    Brain Res Bull 63:75-82. 2004
    ..This later effect seemed to be derived from beta-Ala, not His. These results suggest that central carnosine may act in the brain of chicks to regulate brain function and/or behavior in a manner different from its constituents...
  69. ncbi Intraseptal muscarinic ligands and galanin: influence on hippocampal acetylcholine and cognition
    E Elvander
    Department of Neuroscience, Division of Behavioral Neuroscience, Karolinska Institutet, Retzius vag 8, SE 171 77 Stockholm, Sweden
    Neuroscience 126:541-57. 2004
    ..In summary, a limited range of cholinergic muscarinic transmission may contribute to optimal hippocampal function, a finding that has important implications for therapeutic approaches in the treatment of disorders of memory function...
  70. ncbi Characterization of CART neurons in the rat and human hypothalamus
    C F Elias
    Department of Neurology, Beth Israel Deaconess Medical Center, 99 Brookline Avenue, Boston, Massachusetts 02215, USA
    J Comp Neurol 432:1-19. 2001
    ..The distribution of CART cell bodies and fibers in the human hypothalamus indicates that CART may also play a role in the regulation of energy homeostasis in humans...
  71. ncbi Administration of myr(+)-G(i2)alpha subunits prevents acute tolerance (tachyphylaxis) to mu-opioid effects in mice
    J Garzon
    Neurofarmacologia, Instituto de Neurobiologia Santiago Ramon y Cajal, Consejo Superior de Investigaciones Cientificas, Avenida Doctor Arce 37, E 28002 Madrid, Spain
    Neuropharmacology 40:560-9. 2001
    ..Exogenous administration of myr(+)-G alpha subunits may be of therapeutic potential in improving agonist activity and accelerating the recovery of post-dependent receptors...
  72. ncbi Actions of cocaine- and amphetamine-regulated transcript (CART) peptide on regulation of appetite and hypothalamo-pituitary axes in vitro and in vivo in male rats
    S A Stanley
    Endocrine Unit, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
    Brain Res 893:186-94. 2001
    ..This suggests that CART peptide may play a role in the control of pituitary function and in particular the hypothalamo-pituitary adrenal axis...
  73. ncbi A role for kisspeptins in the regulation of gonadotropin secretion in the mouse
    M L Gottsch
    Department of Physiology and Biophysics Health Sciences Building, G 424 School of Medicine University of Washington, Box 357290, 1959 Northeast Pacific Street, Seattle, Washington 98195 7290, USA
    Endocrinology 145:4073-7. 2004
    ..We conclude that kisspeptin-GPR54 signaling may be part of the hypothalamic circuitry that governs the hypothalamic secretion of GnRH...
  74. ncbi Evaluation of delta receptor mediation of supraspinal opioid analgesia by in vivo protection against the beta-funaltrexamine antagonist effect
    P Sanchez-Blazquez
    Cajal Institute, C S I C, Madrid, Spain
    Eur J Pharmacol 159:9-23. 1989
    ..These results suggest that delta ligands, after binding to delta receptors, also need to act upon mu receptors to produce high levels of supraspinal analgesia in the tail immersion test...
  75. ncbi Increased ATP content/production in the hypothalamus may be a signal for energy-sensing of satiety: studies of the anorectic mechanism of a plant steroidal glycoside
    David B MacLean
    Division of Endocrinology, Hallett Center for Diabetes and Endocrinology, Brown Medical School, Coro Building Providence, RI 02903, USA
    Brain Res 1020:1-11. 2004
    ....
  76. ncbi Central administration of ghrelin and agouti-related protein (83-132) increases food intake and decreases spontaneous locomotor activity in rats
    Mads Tang-Christensen
    Pharmacology, Rheoscience A S, Glerupvej 2, DK 2610 Roedovre, Denmark
    Endocrinology 145:4645-52. 2004
    ..Expanding the current model of food intake control to include mechanisms regulating physical activity may promote our understanding of two major etiological factors causing obesity...
  77. ncbi Chronic intracerebral prolactin attenuates neuronal stress circuitries in virgin rats
    Nina Donner
    Department of Behavioural Neuroendocrinology, University of Regensburg, Regensburg, Germany
    Eur J Neurosci 25:1804-14. 2007
    ....
  78. pmc The adenosine A2A receptor agonist, CGS-21680, blocks excessive rearing, acquisition of wheel running, and increases nucleus accumbens CREB phosphorylation in chronically food-restricted rats
    Soledad Cabeza de Vaca
    Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    Brain Res 1142:100-9. 2007
    ..Medications targeting the A(2A) receptor may have utility in the treatment of maladaptive behaviors associated with FR, including substance abuse and compulsive exercise...
  79. ncbi Dopaminergic drugs may counteract behavioral and biochemical changes induced by models of brain injury
    V Micale
    Department of Experimental and Clinical Pharmacology, Faculty of Medicine, University of Catania, Viale A Doria, 6, 95125 Catania, Italy
    Eur Neuropsychopharmacol 16:195-203. 2006
    ..Their neuroprotective activity probably involves the reduction/oxidation balance of the glutathione system in the brain...
  80. ncbi Bone marrow stromal cells infused into the cerebrospinal fluid promote functional recovery of the injured rat spinal cord with reduced cavity formation
    Masayoshi Ohta
    Department of Plastic and Reconstructive Surgery, Kyoto University Graduate School of Medicine, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Exp Neurol 187:266-78. 2004
    ....
  81. ncbi Centrally and peripherally administered ghrelin potently inhibits water intake in rats
    Hirofumi Hashimoto
    Department of Physiology, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Endocrinology 148:1638-47. 2007
    ..The present study convincingly showed that ghrelin is a potent antidisogenic peptide in rats...
  82. ncbi Role of neuroactive steroid allopregnanolone in antipsychotic-like action of olanzapine in rodents
    Rajesh R Ugale
    University Department of Pharmaceutical Sciences, Nagpur University Campus, Nagpur, Maharashtra, India
    Neuropsychopharmacology 29:1597-609. 2004
    ..The present findings provide the first specific behavioral evidence in support of the hypothesis that neuroactive steroid ALLO- mediated GABAergic modulation is essential for the antipsychotic-like action of olanzapine...
  83. ncbi Effects of orphanin FQ on central dopaminergic neuronal activities and prolactin secretion
    K Shieh
    Department of Physiology, School of Life Science, National Yang-Ming University, Taipei 11221, Taiwan
    Am J Physiol Regul Integr Comp Physiol 280:R705-12. 2001
    ..These results indicate that OFQ and its receptors may be involved in the regulation of central DA neuronal activity and PRL secretion...
  84. ncbi Regulation of feeding by galnon
    Urho Abramov
    Department of Physiology, Tartu University, Ravila 19, Tartu 50 411, Estonia
    Neuropeptides 38:55-61. 2004
    ..These data demonstrate that galnon is a promising tool for studies of the involvement of galanin in feeding disorders and other behavioral processes...
  85. ncbi Runway self-administration of intracerebroventricular cocaine: evidence of mixed positive and negative drug actions
    Daniel Guzman
    Behavioral Pharmacology Laboratory, Department of Psychology, University of California, Santa Barbara, California 93106 9660, USA
    Behav Pharmacol 18:53-60. 2007
    ..These results suggest that the intracerebroventricular self-administration of cocaine results in mixed positive and negative consequences and therefore likely stem from the drug's actions within the central nervous system...
  86. ncbi Induction of Fos immunoreactivity labeling in rat forebrain metabolic loci by caudal fourth ventricular infusion of the monocarboxylate transporter inhibitor, alpha-cyano-4-hydroxycinnamic acid
    Karen P Briski
    Department of Basic Pharmaceutical Sciences, School of Pharmacy, College of Health Sciences, University of Louisiana, Monroe, LA 71209, USA
    Neuroendocrinology 82:49-57. 2005
    ....
  87. ncbi Intraventricular ghrelin activates oxytocin neurons: implications in feeding behavior
    Pawel K Olszewski
    Minnesota Obesity Center, Veterans Affairs Medical Center, Department of Food Science and Nutrition, University of Minnesota, St Paul, Minneapolis 55108, USA
    Neuroreport 18:499-503. 2007
    ..Our data suggest that oxytocin may be responsible for the mediation of some effects induced by ghrelin. Modifications in the activity of the oxytocin system may alter some of these effects...
  88. ncbi Quinolinic acid promotes seizures and decreases glutamate uptake in young rats: reversal by orally administered guanosine
    Diogo Losch de Oliveira
    Departamento de Bioquimica, ICBS, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos 2600 anexo, Porto Alegre, RS, 90 035 003 Brazil
    Brain Res 1018:48-54. 2004
    ..This points that guanosine could be considered for treatments of epilepsy, and possibly other neurological disorders in children...
  89. ncbi Transcriptional involvement of protein kinase C-alpha isozyme in amphetamine-mediated appetite suppression
    Yih Shou Hsieh
    Institute of Biochemistry, Chung Shan Medical University, Taichung, Taiwan, ROC
    Eur J Neurosci 22:715-23. 2005
    ..These results suggest that PKC isotypes- (at least the alpha isotype), related modification of NPY gene expression in hypothalamus might play an essential role in the central regulation of AMPH-mediated feeding suppression...
  90. ncbi Time- and dose-dependent effects of corticotropin releasing factor on cerebral glucose metabolism in rats
    U Freo
    Department of Neurosciences, University of Padova, Italy
    J Neural Transm 112:1447-62. 2005
    ..The findings indicate that cerebellar areas and brainstem nuclei are highly sensitive to oCRF and may mediate oCRF autonomic and behavioral effects...
  91. ncbi Antinociceptive, brain-penetrating derivatives related to improgan, a non-opioid analgesic
    Lindsay B Hough
    Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, NY 12208, USA
    Eur J Pharmacol 522:38-46. 2005
    ....
  92. ncbi Small-conductance Ca(2+)-activated K(+) channels: Heterogeneous affinity in rat brain structures and cognitive modulation by specific blockers
    Bedel Mpari
    Laboratoire de Neurobiologie Integrative et Adaptative, Neurobiologie des Processus Mnésiques, UMR 6149, CNRS Université de Provence, Centre St Charles, Marseille Cedex 03, France
    Eur J Pharmacol 589:140-8. 2008
    ..The variability of IC(50) values suggests that K(Ca)2 channel composition varies considerably as a function of the brain structure considered...
  93. ncbi Role of withdrawal in reinstatement of morphine-conditioned place preference
    Lin Lu
    National Laboratory of Medical Neurobiology and Pharmacology Research Center, Fudan University, 138 Yi Xue Yuan Road, Shanghai 200032, China
    Psychopharmacology (Berl) 181:90-100. 2005
    ..However, the role of withdrawal in relapse has not yet been systemically investigated in the reinstatement model...
  94. ncbi Postnatal intracerebroventricular exposure to leptin causes an altered adult female phenotype
    Amit Varma
    Divisions of Neonatology and Developmental Biology, Dept of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, 10833 LeConte Ave, MDCC B2 375, Los Angeles, CA 90095 1752, USA
    Am J Physiol Endocrinol Metab 287:E1132-41. 2004
    ..001) were observed only in the adult female. We conclude that postnatal leptin administration alters the adult female phenotype and speculate that this may relate to retention of leptin sensitivity resulting in a lipoatrophic state...
  95. pmc Intrathecal rosiglitazone acts at peroxisome proliferator-activated receptor-gamma to rapidly inhibit neuropathic pain in rats
    Sajay B Churi
    Department of Pharmacology, School of Medicine, Tulane University, New Orleans, Louisiana, USA
    J Pain 9:639-49. 2008
    ..New or currently available drugs targeted at spinal PPAR-gamma may yield important therapeutic effects for the management of neuropathic pain...
  96. ncbi Interleukin (IL)-6 and IL-1 beta act synergistically within the brain to induce sickness behavior and fever in rats
    Lois M Harden
    Brain Function Research Group, School of Physiology, Medical School, University of the Witwatersrand, 7 York Road, Parktown, Gauteng, Johannesburg, South Africa
    Brain Behav Immun 22:838-49. 2008
    ..These results show that species-homologous rat IL-6 and IL-1 beta can act directly within the brain to decrease voluntary activity and suggest they also can act synergistically to induce anorexia and fever...
  97. ncbi Functional evaluation of THIQ, a melanocortin 4 receptor agonist, in models of food intake and inflammation
    Ruta Muceniece
    Faculty of Medicine, University of Latvia, Riga, Latvia
    Basic Clin Pharmacol Toxicol 101:416-20. 2007
    ....
  98. ncbi Chronic morphine sensitizes the brain norepinephrine system to corticotropin-releasing factor and stress
    Guang Ping Xu
    Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 24:8193-7. 2004
    ..g., hyperarousal, attentional dysfunction), and this may contribute to the maintenance of opiate-seeking behavior...
  99. pmc Hypothalamic neuronal histamine mediates the thyrotropin-releasing hormone-induced suppression of food intake
    Koro Gotoh
    Department of Internal Medicine 1, Faculty of Medicine, Oita University, Yufu, Oita, Japan
    J Neurochem 103:1102-10. 2007
    ..These results indicate that hypothalamic neuronal histamine mediates the TRH-induced suppression of feeding behavior...
  100. ncbi Further evidence for the mediation of both subtypes of dopamine D1/D2 receptors and cerebral neuropeptide Y (NPY) in amphetamine-induced appetite suppression
    Dong Yih Kuo
    Department of Physiology, Chung Shan Medical University, Taichung City, Taiwan 402, ROC
    Behav Brain Res 147:149-55. 2003
    ..Taken together, the present results confirmed that both subtypes of D1 and D2 receptors and cerebral NPY were involved in the anorectic action of AMPH...
  101. ncbi Corticotropin-releasing factor and behavior
    G F Koob
    Fed Proc 44:259-63. 1985
    ..These results suggest that CRF liberated directly into the central nervous system may have a neurotropic action important for mobilizing behavioral responses to stress...

Research Grants70

  1. NEUROPEPTIDES AND SALT APPETITE
    FRANCIS FLYNN; Fiscal Year: 2007
    ..Successful completion of the proposed work will expand the knowledge base on brain mechanisms controlling bodily fluid homeostasis. ..
  2. PHYSIOLOGY OF THE PROLACTIN RELEASING PEPTIDES
    Willis K Samson; Fiscal Year: 2010
    ..Additionally, these studies will provide further insight into the coordinated hormonal and autonomic responses to stress. ..
  3. Neuroscience Center for Biomedical Research Excellence
    Francis W Flynn; Fiscal Year: 2010
    ....
  4. Translating a CSF delivered AAV9-SMN for treatment of Spinal Muscular Atrophy
    Brian K Kaspar; Fiscal Year: 2013
    ..When virus is delivered to the CSF, via intraventricular injections, we and others13,17 have demonstrated that SMA mice survive significantly longer, greater than 100 days ..
  5. Receptor-mediated S1P signaling in the embryonic brain
    Jerold Chun; Fiscal Year: 2010
    ..brain or cortex can be grown ex vivo while maintaining normal anatomical landmarks and b) embryonic intraventricular injections of ligands...
  6. CLINICAL PHARMACOLOGY CENTER
    Michael Murphy; Fiscal Year: 1991
    ..Intraperitoneal and intraventricular injections will be performed...
  7. CENTRAL & PERIPHERAL EFFECT OF VINBLASTINE & VINCRISTINE
    SHARON COREY; Fiscal Year: 1980
    ..The effects of VLB and VCR on central neurotransmitters will be determined after intraventricular injections directly into specific brain areas...
  8. CAMP AND CATECHOLAMINES IN REPRODUCTIVE FUNCTION
    Gary Davis; Fiscal Year: 1980
    ..For rhesus monkey, intraventricular injections of agonists will be followed by collection of CSF for assay...
  9. EFFECTS OF DRUGS ON NEUROCHEMICAL MATURATION OF BRAIN
    RANBIR BHATNAGAR; Fiscal Year: 1980
    ..of neurochemical and morphological maturation during gestational or neonatal stages by (1) neonatal or intraventricular injections of 6-hydroxydopamine and capsaicin; (2) with the use of neuroleptic drugs that are known to act by ..
  10. Orexinergic Pathways in Central Autonomic Control
    WILLIS SAMSON; Fiscal Year: 2005
    ..abstract_text> ..
  11. Behavior of Stem Cells in the Lesioned Aging Hippocampus
    Ashok Shetty; Fiscal Year: 2006
    ..abstract_text> ..
  12. Repair of Chronially Injured Hippocampus by Grafts
    Ashok Shetty; Fiscal Year: 2006
    ..These studies also have implications for the treatment of other neurodegenerative conditions such as stroke and head injury. [unreadable] [unreadable]..
  13. Mechanisms of Leptin Signaling in the Hypothalamus
    Abhiram Sahu; Fiscal Year: 2007
    ..These studies will further our understanding of leptin signaling in the hypothalamus in relation to feeding, and therefore will be relevant to the development of therapeutic approaches to eating disorders. [unreadable] [unreadable]..
  14. Reduction of Amyloid Burden by Antisense APP
    Neelima Chauhan; Fiscal Year: 2005
    ..Significance: Targeting the translation of amyloidogenic APP by antisense synthetic oligodeoxynucleotides may prove to be an effective and safe form of gene therapy for treating familial AD and other genetic diseases. ..
  15. NON-OPIOID ANALGESICS DERIVED FROM IMPROGAN
    LINDSAY HOUGH; Fiscal Year: 2006
    ..These experiments will help to discover the mechanism of action of this novel class of agents, and lead to the development of new pharmacotherapies for pain. ..
  16. Determining Therapeutic Efficacy of AGE in AD
    Neelima Chauhan; Fiscal Year: 2005
    ..If successful, this project will validate the use of safe, naturally well-tolerated, cost-effective and alternative herbal pharmacotherapy for treating AD. ..
  17. HISTAMINERGIC MECHANISMS OF ANTINOCICEPTION
    LINDSAY HOUGH; Fiscal Year: 2009
    ..abstract_text> ..
  18. MENTORED PATIENT ORIENTED RESEARCH CAREER DEVELOPMENT AW
    John Sampson; Fiscal Year: 2004
    ....
  19. LEPTIN ACTION ON HYPOTHALAMIC PEPTIDES GOVERNING FEEDING
    Abhiram Sahu; Fiscal Year: 2001
    ..These studies will further our understanding of leptin signaling in the hypothalamus in relation to feeding, and therefore will be relevant to the development of therapeutic approaches to eating disorders. ..
  20. Monoamine Transporters and Nonhman Primate Cocaine Use
    HEATHER KIMMEL; Fiscal Year: 2006
    ..The training experiences described will provide for the candidate's transition from a mentored scientist to an independent investigator. [unreadable] [unreadable] [unreadable] [unreadable]..
  21. Dendritic Cell Immunotherapy of Malignant Gliomas
    John Sampson; Fiscal Year: 2006
    ..abstract_text> ..
  22. Intracerebral Infusion of Radiolabeled Specific Antibody
    John Sampson; Fiscal Year: 2006
    ..abstract_text> ..
  23. NEURAL HIERARCHY IN THE MODULATION OF INGESTIVE BEHAVIOR
    HARVEY GRILL; Fiscal Year: 2008
    ..Results will also aid in guiding the design of new drugs and physiologically-based strategies for treating obesity as well as other, feeding-related pathologies. ..
  24. Cannabinoid Regulation of Basal Ganglia Glutamate and GABA
    SCOTT RAWLS; Fiscal Year: 2007
    ..Our outcomes will be a first step in determining whether blocking endocannabinoid inactivation offers any therapeutic advantage over direct activation of cannabinoid receptors with marijuana. [unreadable] [unreadable] [unreadable]..
  25. COR HONORS HIGH SCHOOL RESEARCH EDUCATION
    Joseph Dunbar; Fiscal Year: 2005
    ..abstract_text> ..
  26. Can beta-lactam antibiotics decrease morphine physical dependence?
    SCOTT RAWLS; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  27. Leptin resistance: 1 mechanism underlying age-related obesity
    PHILIP SCARPACE; Fiscal Year: 2008
    ..Such discoveries may lead to new treatments for obesity and the diabetes associated with obesity. ..
  28. Microscopic Quantitative Mapping Ion Flux in Rat Brain
    Karen Briski; Fiscal Year: 2003
    ..This research will significantly advance current understanding of the cellular and molecular bases linking neuronal energetics with homeostatic regulation of glucose availability. ..
  29. Cardio-renal actions of novel nociceptin analogues
    DANIEL KAPUSTA; Fiscal Year: 2008
    ..It is anticipated that work in this area will provide new strategies for the treatment of different pathological states associated with fluid retention and/or hyponatremia/hypokalemia. ..
  30. Neurotransmission evoked by 5HT-dependent luminal factor
    Ying Li; Fiscal Year: 2005
    ..Finally, we will examine the roles of various neurotransmitters in the DMN in the mediation of pancreatic secretion stimulated by luminal 5HT-dependent factors using a conscious rat model. ..
  31. Role of the Amygdala in Opioid Self-administration in Rats with Chronic Pain.
    Thomas Martin; Fiscal Year: 2009
    ....
  32. CNS Fatty Acid Metabolism in Regulation of Food Intake
    Susan Aja; Fiscal Year: 2007
    ..We will measure changes in intracellular AMP/ATP ratio and activity of AMP-activated protein kinase, levels of mRNAs for feeding-related neuropeptides, and neuropeptide production and release. ..
  33. Prion Transport Across the Blood-Brain Barrier
    William Banks; Fiscal Year: 2009
    ..To cause disease, prions must cross the blood-brain barrier to enter the brain. We will determine how prions cross the BBB. Knowing how prions enter the brain should lead to strategies on how to prevent prion diseases. ..
  34. Hindbrain integration of adiposity and satiety signals
    Diana Williams; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  35. Urocortins Brain CRF2 Receptors and Energy Balance
    Eric P Zorrilla; Fiscal Year: 2010
    ....
  36. OPIOIDS AND CENTRAL NEURAL REGULATION OF RENAL FUNCTION
    DANIEL KAPUSTA; Fiscal Year: 2007
    ..abstract_text> ..
  37. Galanin Control of Food Intake: Molecular, Neuroanatomical and Behavioral Bases
    Eric P Zorrilla; Fiscal Year: 2010
    ....
  38. Programmed adiposity: genetic in utero and postnatal determinants
    Eric Zorrilla; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  39. Effect of CRF1 Receptor Genotype and Stress on Anxiety and Alcohol Endophenotypes
    Lisa Conti; Fiscal Year: 2008
    ..The purpose of these studies is to examine the relationship between stress and different CRF genotypes on anxiety and alcohol use endophenotypes. [unreadable] [unreadable] [unreadable]..
  40. Modulation of Hippocampal Neurogenesis and Cognitive Recovery Following Trauma
    Dong Sun; Fiscal Year: 2010
    ....
  41. ANTIDEPRESSANT THERAPY AND HYPOGLYCEMIA
    Dianne Lattemann; Fiscal Year: 2006
    ..non-diabetic rats. The results of these studies will provide new knowledge that ultimately may assist primary physicians in determining the most advantageous treatment for their diabetic patients with depression. ..
  42. CNS AND SALT APPETITE
    DOUGLAS FITTS; Fiscal Year: 2004
    ..The results will have implications for the central control of blood pressure and endocrine secretions as well as behavior during various challenges to body hydration. ..
  43. Developmental Affects of Ritalin on Brain
    TERESA MILNER; Fiscal Year: 2004
    ..Determining how therapeutic dosage regimens effect these transmitter systems is critical in understanding the safety of long-term therapeutic doses of MPH administered to children and adolescents with ADHD and other related disorders. ..
  44. Cytokines and Memory Consolidation
    RUTH BARRIENTOS; Fiscal Year: 2004
    ..These studies will answer some important questions about where and how pro-inflammatory cytokines may act to impair hippocampal-dependent memory processes. ..
  45. CNS Stress Pathways and the Development of Acute HAAF
    Dianne Lattemann; Fiscal Year: 2003
    ..abstract_text> ..
  46. OPIOIDS AND CENTRAL NEURAL REGULATION OF RENAL FUNCTION
    DANIEL KAPUSTA; Fiscal Year: 2003
    ..In summary, an RCDA will greatly enhance my research productivity and scientific career. ..
  47. NO AND THE MAGNOCELLULAR NEUROENDOCRINE SYSTEM
    MASSAKO KADEKARO KUTYNA; Fiscal Year: 2002
    ....
  48. IMPAIRED LEPTIN RESPONSIVENESS WITH AGE
    PHILIP SCARPACE; Fiscal Year: 2002
    ..The potential for vitamin A supplementation to reverse the age-related increase in serum leptin and restore leptin responsiveness is addressed in this proposal. ..
  49. Mechanisms of HIV Transport Across the BBB
    William Banks; Fiscal Year: 2004
    ....
  50. NPY elicits meal-anticipatory responses
    DEBORAH DRAZEN; Fiscal Year: 2005
    ....
  51. Age-related Obesity: Interventions with Gene Delivery
    PHILIP SCARPACE; Fiscal Year: 2006
    ..Such discoveries may lead to new treatments for obesity and the diabetes associated with obesity. ..
  52. Neural Analysis of Maternal Aggression
    STEPHEN GAMMIE; Fiscal Year: 2006
    ..Basic research into sex differences in aggression, then, is important to understanding the biological underpinnings of sex and gender differences in social behavior, health, and disease. ..
  53. Thrombin and CNS: Gastric Dysfunction after Head Trauma
    Gerlinda Hermann; Fiscal Year: 2006
    ..e., via an R01 funding program). ..
  54. Interleukin and the Magnocellular Neuroendocrine System
    Joan Summy Long; Fiscal Year: 2005
    ..abstract_text> ..
  55. Role of the CRF2 Receptor in Ingestive Behavior
    Eric Zorrilla; Fiscal Year: 2005
    ..The proposed studies will address these questions as well to understand better the role of the CRF2 receptor in feeding behavior. ..
  56. EXTRAMULAR RESEARCH FACILITIES CONSTRUCTION
    Robert Shade; Fiscal Year: 2003
    ..Thus, the design of the proposed laboratory facility will provide efficient space currently needed by these programs while also improving the collaborative research environment for faculty and staff. ..
  57. BRAIN GALANIN RECEPTORS AND EPILEPSY
    Andrey Mazarati; Fiscal Year: 2006
    ..abstract_text> ..
  58. Angiotensin, Sodium and Genes in Primate Hypertension
    Robert Shade; Fiscal Year: 2005
    ..Importantly, this work will also reveal whether the genetically determined phenotype of high SLC is important in predisposing an animal to sodium-dependent hypertension. ..
  59. Pilot/Phase I Study of Intrathecal Laronidase for Spinal Cord Compression in Muco
    Patricia Dickson; Fiscal Year: 2009
    ..If successful, delivery into the spinal fluid could represent a practical, straightforward method of treating central nervous system disease due to lysosomal storage. ..
  60. Volatile Anesthetic Action in Vertebrate Locomotor Systems
    Steven L Jinks; Fiscal Year: 2010
    ..Results from these projects will increase our understanding of how and where anesthetics act in the nervous system, contributing to the development of safer anesthetics and clinical practices. ..
  61. NEURAL BASIS OF TASTE ELICITED INGESTION AND REJECTION
    JOSEPH TRAVERS; Fiscal Year: 2009
    ..Understanding the neurological basis of the fundamental biological decision ingest or reject food will contribute to the eventual solution of these chronic debilitating disorders. ..
  62. Heart Rate Variability in Mecp2 Deficient Mice
    JOHN BISSONNETTE; Fiscal Year: 2005
    ..These studies will contribute to the understanding of depressed parasympathetic activity in Rett syndrome. ..
  63. Assay for HTS of Gi/Go-linked GPCRs: mGluR7 as Prot(RMI)
    COLLEEN NISWENDER; Fiscal Year: 2007
    ..abstract_text> ..
  64. PTS1 Regulation of Brain Met Enk Levels in Alcoholism
    William Banks; Fiscal Year: 2004
    ..abstract_text> ..
  65. METABOTROPIC GLUTAMATE RECEPTORS IN BASAL GANGLIA
    COLLEEN NISWENDER; Fiscal Year: 2009
    ..Furthermore, we will test the hypothesis that agonists or allosteric potentiators of this receptor can provide palliative relief in rodent models of PD by actions in the GP. ..
  66. Measurement of GPCR-mediated thallium flux:GIRK (RMI)
    COLLEEN NISWENDER; Fiscal Year: 2005
    ..Identified compounds will provide new pharmacological tools to test the role of the ?2C adrenergic receptor in psychiatric and cardiovascular disorders and the role of GIRK 1/2 channels in the modulation of neuronal excitability. ..