intravenous injections

Summary

Summary: Injections made into a vein for therapeutic or experimental purposes.

Top Publications

  1. ncbi Effect of ondansetron pretreatment on pain after rocuronium and propofol injection: a randomised, double-blind controlled comparison with lidocaine
    M S Reddy
    Department of Anaesthesia, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074
    Anaesthesia 56:902-5. 2001
  2. ncbi Intravenous adenosine and dyspnea in humans
    Nausherwan K Burki
    Div of Pulmonary Medicine, Department of Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 1225, USA
    J Appl Physiol (1985) 98:180-5. 2005
  3. ncbi Antitumor activity of small interfering RNA/cationic liposome complex in mouse models of cancer
    Junichi Yano
    Discovery Research Laboratories, Nippon Shinyaku Co, Ltd, Kyoto, Japan and Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
    Clin Cancer Res 10:7721-6. 2004
  4. pmc Lethal injection for execution: chemical asphyxiation?
    Teresa A Zimmers
    DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida, United States of America
    PLoS Med 4:e156. 2007
  5. ncbi Vitamin C pharmacokinetics: implications for oral and intravenous use
    Sebastian J Padayatty
    National Institute of Diabetes and Digestive and Kidney Diseases, the National Cancer Institut, and the Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 1372, USA
    Ann Intern Med 140:533-7. 2004
  6. ncbi Circulation and biodistribution profiles of long-circulating PEG-liposomes of various sizes in rabbits
    V D Awasthi
    Department of Radiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Int J Pharm 253:121-32. 2003
  7. ncbi Response of man to endotoxin
    G D Martich
    Critical Care Medicine Department, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD
    Immunobiology 187:403-16. 1993
  8. ncbi A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer
    Richard M Goldberg
    Division of Hematology Oncology, University of North Carolina at Chapel Hill, CB 7305, 3009 Old Clinic Building, Chapel Hill, NC 27599 7305, USA
    J Clin Oncol 22:23-30. 2004
  9. pmc Ferumoxytol as an intravenous iron replacement therapy in hemodialysis patients
    Robert Provenzano
    St John Hospital and Medical Center, Detroit, Michigan, USA
    Clin J Am Soc Nephrol 4:386-93. 2009
  10. ncbi Progression of changes in dopamine transporter binding site density as a result of cocaine self-administration in rhesus monkeys
    S R Letchworth
    Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA
    J Neurosci 21:2799-807. 2001

Detail Information

Publications298 found, 100 shown here

  1. ncbi Effect of ondansetron pretreatment on pain after rocuronium and propofol injection: a randomised, double-blind controlled comparison with lidocaine
    M S Reddy
    Department of Anaesthesia, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074
    Anaesthesia 56:902-5. 2001
    ..0001) compared with placebo, and significantly better with lidocaine than with ondansetron (p = 0.02). We conclude that ondansetron is effective in relieving the pain of rocuronium but is not as effective as lidocaine...
  2. ncbi Intravenous adenosine and dyspnea in humans
    Nausherwan K Burki
    Div of Pulmonary Medicine, Department of Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 1225, USA
    J Appl Physiol (1985) 98:180-5. 2005
    ....
  3. ncbi Antitumor activity of small interfering RNA/cationic liposome complex in mouse models of cancer
    Junichi Yano
    Discovery Research Laboratories, Nippon Shinyaku Co, Ltd, Kyoto, Japan and Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
    Clin Cancer Res 10:7721-6. 2004
    ..In this study, we have investigated the antitumor activity of a synthetic siRNA, B717, which is sequence specific for the human bcl-2 oncogene, complexed with a novel cationic liposome, LIC-101...
  4. pmc Lethal injection for execution: chemical asphyxiation?
    Teresa A Zimmers
    DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida, United States of America
    PLoS Med 4:e156. 2007
    ..We sought to determine whether the current drug regimen results in death in the manner intended...
  5. ncbi Vitamin C pharmacokinetics: implications for oral and intravenous use
    Sebastian J Padayatty
    National Institute of Diabetes and Digestive and Kidney Diseases, the National Cancer Institut, and the Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 1372, USA
    Ann Intern Med 140:533-7. 2004
    ..Early clinical studies of vitamin C in patients with terminal cancer suggested clinical benefit, but 2 double-blind, placebo-controlled trials showed none. However, these studies used different routes of administration...
  6. ncbi Circulation and biodistribution profiles of long-circulating PEG-liposomes of various sizes in rabbits
    V D Awasthi
    Department of Radiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Int J Pharm 253:121-32. 2003
    ..Beyond this range, the stealth property of PEG-liposomes is significantly compromised and the distribution is characterized by high RES accumulation...
  7. ncbi Response of man to endotoxin
    G D Martich
    Critical Care Medicine Department, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD
    Immunobiology 187:403-16. 1993
    ..Defining the pathways and responses initiated during acute human endotoxemia may allow a better understanding of host responses that are critical to the development of organ dysfunction and shock due to severe infections...
  8. ncbi A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer
    Richard M Goldberg
    Division of Hematology Oncology, University of North Carolina at Chapel Hill, CB 7305, 3009 Old Clinic Building, Chapel Hill, NC 27599 7305, USA
    J Clin Oncol 22:23-30. 2004
    ..In this study, we compared the activity and toxicity of three different two-drug combinations in patients with metastatic colorectal cancer who had not been treated previously for advanced disease...
  9. pmc Ferumoxytol as an intravenous iron replacement therapy in hemodialysis patients
    Robert Provenzano
    St John Hospital and Medical Center, Detroit, Michigan, USA
    Clin J Am Soc Nephrol 4:386-93. 2009
    ..Intravenous iron is a key component of anemia management for chronic kidney disease (CKD). Ferumoxytol is a unique intravenous iron product that can be administered as a rapid injection in doses up to 510 mg...
  10. ncbi Progression of changes in dopamine transporter binding site density as a result of cocaine self-administration in rhesus monkeys
    S R Letchworth
    Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA
    J Neurosci 21:2799-807. 2001
    ....
  11. ncbi Vascular reactions to in vivo electroporation: characterization and consequences for drug and gene delivery
    Julie Gehl
    Department of Oncology, University of Copenhagen in Herlev Hospital, Denmark
    Biochim Biophys Acta 1569:51-8. 2002
    ....
  12. ncbi The effect of correction of mild anemia in severe, resistant congestive heart failure using subcutaneous erythropoietin and intravenous iron: a randomized controlled study
    D S Silverberg
    Department of Nephrology and Cardiology and Congestive Heart Failure Program, Tel Aviv Medical Center, Israel
    J Am Coll Cardiol 37:1775-80. 2001
    ..6% in B. CONCLUSIONS: When anemia in CHF is treated with EPO and IV iron, a marked improvement in cardiac and patient function is seen, associated with less hospitalization and renal impairment and less need for diuretics...
  13. ncbi Complete remission of experimental arthritis by joint targeting of glucocorticoids with long-circulating liposomes
    Josbert M Metselaar
    Utrecht Institute of Pharmaceutical Sciences, Utrecht, The Netherlands
    Arthritis Rheum 48:2059-66. 2003
    ....
  14. ncbi Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
    Jürgen Soutschek
    Alnylam Europe AG, Fritz Hornschuch Str 9, 95326 Kulmbach, Germany
    Nature 432:173-8. 2004
    ..These findings demonstrate the therapeutic potential of siRNAs for the treatment of disease...
  15. ncbi Colectomy rate comparison after treatment of ulcerative colitis with placebo or infliximab
    William J Sandborn
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA
    Gastroenterology 137:1250-60; quiz 1520. 2009
    ..The efficacy of infliximab for treating patients with ulcerative colitis has been established...
  16. pmc Ferumoxytol for treating iron deficiency anemia in CKD
    Bruce S Spinowitz
    Nephrology, New York Hospital Medical Center, Queens, New York, USA
    J Am Soc Nephrol 19:1599-605. 2008
    ..This regimen may offer a new, efficient option to treat iron deficiency anemia in patients with CKD...
  17. ncbi Pulse steroid therapy
    Aditi Sinha
    Division of Nephrology, Department of Pediatrics, All India Institute of Medical Sciences New Delhi, Ansari Nagar, New Delhi, India
    Indian J Pediatr 75:1057-66. 2008
    ..Therapy is associated with significant side effects including worsening of hypertension, infections, dyselectrolytemia and behavioral effects. Adequate monitoring is essential during usage...
  18. ncbi Examination of synovial fluid and serum following intravenous injections of hyaluronan for the treatment of osteoarthritis in dogs
    S O Canapp
    Department of Orthopedic Surgery and Sports Medicine, VCA Veterinary Referral Associates, Gaithersburg, Maryland 20878, USA
    Vet Comp Orthop Traumatol 18:169-74. 2005
    ..Stifles with cranial cruciate ligament insufficiency had significant alterations in SF viscosity and HA concentrations...
  19. ncbi Comparative preclinical and clinical pharmacokinetics of a cremophor-free, nanoparticle albumin-bound paclitaxel (ABI-007) and paclitaxel formulated in Cremophor (Taxol)
    Alex Sparreboom
    National Cancer Institute, Bethesda, Maryland 20892, USA
    Clin Cancer Res 11:4136-43. 2005
    ..To compare the preclinical and clinical pharmacokinetic properties of paclitaxel formulated as a Cremophor-free, albumin-bound nanoparticle (ABI-007) and formulated in Cremophor-ethanol (Taxol)...
  20. ncbi Pharmacokinetics of doxycycline after administration as a single intravenous bolus and intramuscular doses to non-lactating Egyptian goats
    A M Abd El-Aty
    Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, 12515 Giza, Egypt
    Pharmacol Res 49:487-91. 2004
    ..The extent of serum protein binding percent was 32.8% and the systemic bioavailability was 99.40% after i.m. injection of 5 mg kg-1 BW..
  21. ncbi Intravenous iron alone for the treatment of anemia in patients with chronic heart failure
    Aidan P Bolger
    Department of Clinical Cardiology, The Heart Hospital, London, United Kingdom
    J Am Coll Cardiol 48:1225-7. 2006
    ..This study was undertaken to assess the hematologic, clinical, and biochemical response to intravenous iron in patients with chronic heart failure (CHF) and anemia...
  22. ncbi Ibandronate: a clinical pharmacological and pharmacokinetic update
    Joanne Barrett
    Roche Products Ltd, 40 Broadwater Road, Welwyn Garden City, Hertfordshire, AL7 3AY, United Kingdom
    J Clin Pharmacol 44:951-65. 2004
    ..The potency of ibandronate and its sequestration into bone allow ibandronate to be developed as oral and intravenous injection formulations that can be administered with convenient extended between-dose intervals...
  23. ncbi Effects of anti-inflammatory agents on serum levels of calcitonin precursors during human experimental endotoxemia
    H L Preas
    Critical Care Medicine Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland, USA
    J Infect Dis 184:373-6. 2001
    ..Of importance, this study reveals that anti-inflammatory agents may modulate the CTpr level, which is a potential toxic mediator of inflammation...
  24. ncbi Intravenous nicotine and caffeine: subjective and physiological effects in cocaine abusers
    B E Garrett
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Pharmacol Exp Ther 296:486-94. 2001
    ..The study documents both striking similarities and some notable differences between caffeine and nicotine, which are among the most widely used mood-altering drugs...
  25. ncbi Interaction between DNA-cationic liposome complexes and erythrocytes is an important factor in systemic gene transfer via the intravenous route in mice: the role of the neutral helper lipid
    F Sakurai
    Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto, Japan
    Gene Ther 8:677-86. 2001
    ..These results indicate that the interaction with erythrocytes depends on the properties of the cationic lipid vectors and this is an important factor for intravenous gene delivery using cationic lipid vectors...
  26. ncbi Early switch and early discharge opportunities in intravenous vancomycin treatment of suspected methicillin-resistant staphylococcal species infections
    Stephen Parodi
    J Manag Care Pharm 9:317-26. 2003
    ..Oral linezolid has excellent bioavailability and activity against MRSA and MR-CoNS and offers the potential for outpatient treatment of MRSA and MR-CoNS infections...
  27. ncbi Self-administration of delta9-tetrahydrocannabinol (THC) by drug naive squirrel monkeys
    Zuzana Justinova
    Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 169:135-40. 2003
    ....
  28. ncbi Pharmacokinetics and bioavailability of doxycycline in fasted and nonfasted broiler chickens
    P Laczay
    Department of Pharmacology and Toxicology, Faculty of Veterinary Science, Szent Istvan University, H 1400 Budapest, P O Box 2, Hungary
    Acta Vet Hung 49:31-7. 2001
    ..5%. The presence of food in the intestinal tract reduced and extended the absorption (t1/2a = 1.23 +/- 0.21 h; Cmax = 3.07 +/- 0.23 micrograms/mL; tmax = 3.34 +/- 0.21 h). The absolute bioavailability was reduced to 61.1% +/- 4.4%...
  29. ncbi Prolonged organ retention and safety of plasmid DNA administered in polyethylenimine complexes
    Y K Oh
    Department of Microbiology, College of Medicine, Pochon CHA University, Kyonggi-do, South Korea
    Gene Ther 8:1587-92. 2001
    ..These results indicate that PEI enhances the delivery and retention of plasmid DNA in the organs, especially the liver, but that safe delivery requires proper dosing intervals...
  30. ncbi Antibody production in mice deficient for complement receptors 1 and 2 can be induced by IgG/Ag and IgE/Ag, but not IgM/Ag complexes
    S E Applequist
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    J Immunol 165:2398-403. 2000
    ..The data also show that the need for CR1/2 can be circumvented by Abs typical of a secondary immune response forming complexes with Ag or by conventional adjuvants, presumably mimicking physiological inflammatory reactions...
  31. ncbi Myocardial uptake and biochemical and hemodynamic effects of ACE inhibitors in humans
    Christopher J Zeitz
    University of Adelaide, Department of Medicine, The Queen Elizabeth Hospital, Adelaide, South Australia, Australia
    Hypertension 41:482-7. 2003
    ..Under resting conditions, both drugs exerted small negative inotropic effects...
  32. ncbi Fatal intravenous injection of potassium in hospitalized patients
    Angela R Wetherton
    Department of Pathology and Laboratory Medicine, University of Louisville School of Medicine, Kentucy, USA
    Am J Forensic Med Pathol 24:128-31. 2003
    ..These cases illustrate the subtlety of findings in such deaths and remind the forensic pathologist to consider this type of event in sudden, unexpected death of hospitalized patients...
  33. ncbi Possible mechanism of gene transfer into early to mid-gestational mouse fetuses by tail vein injection
    N Kikuchi
    Division of Molecular Life Science, School of Medicine, Tokai University, Isehara, Japan
    Gene Ther 9:1529-41. 2002
    ..If significantly improved, gene transfer to fetuses by injection into the maternal circulation may become a promising tool in fetal gene therapy and embryological studies...
  34. ncbi Neonatal intraperitoneal or intravenous injections of recombinant adeno-associated virus type 8 transduce dorsal root ganglia and lower motor neurons
    Kevin D Foust
    Department of Pediatrics, Evelyn F and William L McKnight Brian Institute, University of Florida College of Medicine, Gainesville, FL 32610, USA
    Hum Gene Ther 19:61-70. 2008
    ..Our data suggest that systemic injection of rAAV8 is not an effective delivery route to target lower motor neurons, but could be useful for targeting sensory pathways in chronic pain...
  35. ncbi Cholecystokinin stimulates neuronal receptors to produce contraction of the canine colon
    F C Barone
    Department of Pharmacology, Smith Kline and French Laboratories, King of Prussia, PA 19406
    Life Sci 44:533-42. 1989
    ..b>Intravenous injections of CCK-OP had no effect on colonic motility at doses that contracted the gallbladder, stomach and duodenum...
  36. pmc Tolerance to melanin-associated antigen in autoimmune uveitis is mediated by CD4+CD25+ T-regulatory cells
    Bharati Matta
    Department of Ophthalmology, Jones Eye Institute, Little Rock, AR 72205, USA
    Am J Pathol 173:1440-54. 2008
    ..In conclusion, T-cell nonresponsiveness because of active suppression mediated by T-regulatory cells facilitates the development of tolerance to MAA in EAAU...
  37. pmc Application of microbiological assay to determine pharmaceutical equivalence of generic intravenous antibiotics
    Andres F Zuluaga
    Grupo Investigador de Problemas en Enfermedades Infecciosas, University of Antioquia, Medellin, Colombia
    BMC Clin Pharmacol 9:1. 2009
    ....
  38. ncbi Cell entry targeting restricts biodistribution of replication-competent retroviruses to tumour tissue
    L J Duerner
    Abteilung Medizinische Biotechnologie, Paul Ehrlich Institut, Langen, Germany
    Gene Ther 15:1500-10. 2008
    ..The data raise serious doubts about a safe clinical use of non-targeted MLV. Engineering the virus to become activatable by tumour-associated proteases can significantly improve the safety of MLV...
  39. ncbi Hemicrania continua responsive to intravenous methyl prednisolone
    Sanjay Prakash
    Department of Neurology, Medical College, Baroda, Gujarat, India
    Headache 49:604-7. 2009
    ..Exquisite and persistent effect of indomethacin is a fundamental property of HC. We report 2 patients of HC in which attacks were successfully eliminated by repeated infusion of methyl prednisolone...
  40. pmc Effects of dose and session duration on cocaine self-administration in rats
    Sunmee Wee
    Committee on the Neurobiology of Addictive Disorders, SP30 2400, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Pharmacol Exp Ther 320:1134-43. 2007
    ..Therefore, high doses or prolonged access to cocaine are more likely to result in a pattern of cocaine intake that reflects compulsive use...
  41. ncbi Efficacy and safety of ibandronate given by intravenous injection once every 3 months
    S Adami
    University of Verona, Valeggio, Italy
    Bone 34:881-9. 2004
    ..were randomized to receive either 2 mg (n = 261) or 1 mg (n = 131) ibandronate or placebo (n = 128) intravenous injections, given once every 3 months...
  42. ncbi Impact of tumor-specific targeting and dosing schedule on tumor growth inhibition after intravenous administration of siRNA-containing nanoparticles
    Derek W Bartlett
    Chemical Engineering, California Institute of Technology, 1200 E California Blvd, MC 210 41, Pasadena, California 91125, USA
    Biotechnol Bioeng 99:975-85. 2008
    ....
  43. ncbi FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: a randomized GERCOR study
    Christophe Tournigand
    Hopital Saint Antoine, 184 rue du Faubourg Saint Antoine, 75571 Paris, Cedex 12, France
    J Clin Oncol 22:229-37. 2004
    ..This phase III study investigated two sequences: folinic acid, FU, and irinotecan (FOLFIRI) followed by folinic acid, FU, and oxaliplatin (FOLFOX6; arm A), and FOLFOX6 followed by FOLFIRI (arm B)...
  44. pmc Administration of CD34+ cells after stroke enhances neurogenesis via angiogenesis in a mouse model
    Akihiko Taguchi
    Department of Cerebrovascular Disease, National Cardiovascular Center, Osaka, Japan
    J Clin Invest 114:330-8. 2004
    ..Our data suggest an essential role for CD34(+) cells in promoting directly or indirectly an environment conducive to neovascularization of ischemic brain so that neuronal regeneration can proceed...
  45. ncbi Disposition kinetics, urinary excretion and dosage regimen of levofloxacin formulation following single intravenous administration in crossbred calves
    V K Dumka
    Department of Pharmacology and Toxicology, College of Veterinary Science, Punjab Agricultural University, Ludhiana, India
    Vet Res Commun 31:873-9. 2007
  46. pmc Effective treatment of cutaneous and subcutaneous malignant tumours by electrochemotherapy
    L M Mir
    LPPMB Biochimie Enzymologie, URA 147 CNRS, Institute Gustave Roussy, Villejuif, France
    Br J Cancer 77:2336-42. 1998
    ..ECT was effective regardless of the histological type of the tumour. Therefore, ECT offers an approach to the treatment of cutaneous and subcutaneous tumours in patients with minimal adverse side-effects and with a high response rate...
  47. ncbi Rocuronium-induced generalized spontaneous movements cause pulmonary aspiration
    Jiin Tarng Lui
    Department of Anesthesia, Chang Gung Memorial Hospital, Taipei, ROC
    Chang Gung Med J 25:617-20. 2002
    ..We describe a case of gastric regurgitation with pulmonary aspiration following generalized spontaneous movements associated with rocuronium injection in a girl who received pediatric emergent surgery...
  48. ncbi Pain on i.v. injection of some anaesthetic agents is evoked by the unphysiological osmolality or pH of their formulations
    W Klement
    Department of Experimental Anaesthesiology,
    Br J Anaesth 66:189-95. 1991
    ..We conclude that pain on i.v. injection of some sedative and hypnotic drugs is likely to be caused by formulations of extremely unphysiological osmolalities or pH values...
  49. ncbi Cost analysis applied to postoperative analgesia regimens: a comparison between parecoxib and propacetamol
    P Tilleul
    Department of Pharmacy, Hopital Saint Antoine, 184 rue du Faubourg St Antoine, 75012 Paris, France
    Pharm World Sci 29:374-9. 2007
    ..Postoperative pain management represents a significant part of perioperative costs. Non-opioid analgesics are often used in combination with opiates to improve pain relief and reduce opioid-related side effects...
  50. ncbi Intravenous ibandronate injections in postmenopausal women with osteoporosis: one-year results from the dosing intravenous administration study
    Pierre D Delmas
    Université Claude Bernard Lyon 1 and INSERM Research Unit 403, Lyon, France
    Arthritis Rheum 54:1838-46. 2006
    ..The aim of this study was to identify the optimal intravenous dosing regimen for ibandronate in postmenopausal women with osteoporosis...
  51. ncbi Improved anti-cancer effect of interferon gene transfer by sustained expression using CpG-reduced plasmid DNA
    Hiroki Kawano
    Department of Biopharmaceutics and Drug Metabolism, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto, Japan
    Int J Cancer 121:401-6. 2007
    ..These results indicate that long-term expression of IFN can be achieved by CpG-reduced pDNA and sustained IFN gene expression results in enhanced therapeutic effects of IFN gene transfer against tumor metastasis...
  52. ncbi Comparison of diphenhydramine and lidocaine for prevention of pain after injection of propofol: a double-blind, placebo-controlled, randomized study
    S Apiliogullari
    Ozel Konya Hospital, Department of Anaesthesia and Intensive Care, Turkey
    Eur J Anaesthesiol 24:235-8. 2007
    ..Pain on injection is still a problem with propofol. The purpose of the study was to compare the effectiveness of diphenhydramine and lidocaine on pain caused by propofol at the site of injection...
  53. pmc Effect of mode of hydrocortisone administration on glycemic control in patients with septic shock: a prospective randomized trial
    Pekka Loisa
    Department of Intensive Care, Paijat Hame Central Hospital, Keskussairaalankatu 7, Lahti, Finland
    Crit Care 11:R21. 2007
    ..Hydrocortisone induces hyperglycemia and it is possible that continuous hydrocortisone infusion would reduce the fluctuations in blood glucose levels and that tight blood glucose control could be better achieved with this approach...
  54. pmc Remifentanil prevents withdrawal movements caused by intravenous injection of rocuronium
    Byung In Choi
    Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun gu, Seoul 120 752, Korea
    Yonsei Med J 49:211-6. 2008
    ..This randomized, double-blind, placebo-controlled study was designed to evaluate the effect of pretreatment of remifentanil on the withdrawal movements due to intravenous injection of rocuronium during anesthetic induction...
  55. ncbi Significance and impact of bisphosphonate-induced acute phase responses
    Karin Olson
    University of Michigan Comprehensive Cancer Center
    J Oncol Pharm Pract 13:223-9. 2007
    ....
  56. ncbi Less than 28 days of intravenous antibiotic treatment is sufficient for suppurative thrombophlebitis in injection drug users
    Dominik Mertz
    Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland
    Clin Infect Dis 46:741-4. 2008
    ..A <4-week course of intravenous antibiotics may be sufficient...
  57. ncbi Frequency, management, and outcome of extravasation of nonionic iodinated contrast medium in 69,657 intravenous injections
    Carolyn L Wang
    Department of Radiology, University of Michigan Health System, Ann Arbor, MI 48109 0030, USA
    Radiology 243:80-7. 2007
    ..To determine retrospectively the frequency, management, and outcomes of extravasations of intravenously injected nonionic iodinated contrast medium...
  58. pmc IL-1 receptors mediate persistent, but not acute, airway hyperreactivity to ozone in guinea pigs
    Kirsten C Verhein
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon 97239, USA
    Am J Respir Cell Mol Biol 39:730-8. 2008
    ..Furthermore, preventing hyperreactivity was accompanied by decreased eosinophil major basic protein deposition within the lung, suggesting that IL-1 affects eosinophil activation 3 days after ozone exposure...
  59. ncbi Small interfering RNA delivery to the liver by intravenous administration of galactosylated cationic liposomes in mice
    Ayumi Sato
    GeneCare Research Institute Co Ltd, 200 Kajiwara, Kamakura, Kanagawa 247 0063, Japan
    Biomaterials 28:1434-42. 2007
    ..In conclusion, we demonstrated the hepatocyte-selective gene silencing by galactosylated liposomes following intravenous administration...
  60. ncbi Effective intravenous therapy of murine pulmonary metastases with an oncolytic herpes virus expressing interleukin 12
    Richard J Wong
    Head and Neck Service, Laboratory of Epithelial Cancer Biology, Hepatobiliary Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Clin Cancer Res 10:251-9. 2004
    ..Engineered herpes oncolytic viruses are effective therapeutic agents when delivered directly to tumors in animal models, but their efficacy in treating disseminated disease is poorly defined...
  61. ncbi Dose-related inflammatory effects of intravenous endotoxin in humans: evaluation of a new clinical lot of Escherichia coli O:113 endotoxin
    A F Suffredini
    Critical Care Medicine Department, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    J Infect Dis 179:1278-82. 1999
    ..Thus, in healthy subjects, the magnitude of exposure to CCRE results in a graded dose response of major components of innate immunity...
  62. pmc Increased platinum accumulation in SA-1 tumour cells after in vivo electrochemotherapy with cisplatin
    M Cemazar
    Institute of Oncology, Ljubljana, Slovenia
    Br J Cancer 79:1386-91. 1999
    ..In addition, besides electroporation, immune system and tumour blood flow changes could be involved in the observed anti-tumour effectiveness of electrochemotherapy...
  63. ncbi Assessing analgesia in single and repeated administrations of propacetamol for postoperative pain: comparison with morphine after dental surgery
    Hugo Van Aken
    Department of Anesthesiology and Intensive Care Medicine, University Hospital, University of Munster, Albert Schweitzer Strasse 33, D 48149 Munster, Germany
    Anesth Analg 98:159-65, table of contents. 2004
    ....
  64. pmc Preliminary animal pharmacokinetics of the parenteral antifungal agent MK-0991 (L-743,872)
    R Hajdu
    Antibiotic Discovery and Development, Merck Research Laboratories, Rahway, New Jersey 07065 0900, USA
    Antimicrob Agents Chemother 41:2339-44. 1997
    ..Single daily doses of MK-0991 should provide adequate systemic levels of fungicidal activity as a result of its long half-life pharmacokinetics, wide distribution, and slowly accumulating concentrations in tissue...
  65. ncbi The prevention of pain from injection of rocuronium by magnesium sulphate, lignocaine, sodium bicarbonate and alfentanil
    A Turan
    Departments of Anaesthesiology and Biostatistics, Medical Faculty, Trakya University, Edirne, Turkey
    Anaesth Intensive Care 31:277-81. 2003
    ..Of these drugs, magnesium sulphate, lignocaine and sodium bicarbonate were the most effective while alfentanil was the least effective...
  66. ncbi Combination reperfusion therapy with eptifibatide and reduced-dose tenecteplase for ST-elevation myocardial infarction: results of the integrilin and tenecteplase in acute myocardial infarction (INTEGRITI) Phase II Angiographic Trial
    Robert P Giugliano
    TIMI Study Group, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Am Coll Cardiol 41:1251-60. 2003
    ..The goal of this study was to evaluate combinations of eptifibatide with reduced-dose tenecteplase (TNK) in ST-elevation myocardial infarction (STEMI)...
  67. ncbi Differentiation of gut and hepatic first-pass effect of drugs: 1. Studies of verapamil in ported dogs
    Y H Lee
    DMPK, LION Bioscience, San Diego, California 92121, USA
    Pharm Res 18:1721-8. 2001
    ....
  68. ncbi A comparison of the pharmacological properties of carbohydrate remodeled recombinant and placental-derived beta-glucocerebrosidase: implications for clinical efficacy in treatment of Gaucher disease
    B Friedman
    Cell and Protein Therapeutics Department, Genzyme Corporation, Framingham, MA, USA
    Blood 93:2807-16. 1999
    ..Both molecules had poor stability in LEC and relatively long terminal half-lives in PC (t1/2 = 2 days) and KC (t1/2 = 3 days)...
  69. ncbi Phasic inhibition of dopamine uptake in nucleus accumbens induced by intravenous cocaine in freely behaving rats
    E A Kiyatkin
    Program in Neural Science, Department of Psychology, Indiana University, Bloomington, IN 47405, USA
    Neuroscience 98:729-41. 2000
    ....
  70. ncbi Cerebral hemodynamics in CADASIL before and after acetazolamide challenge assessed with MRI bolus tracking
    H Chabriat
    Department of Neurology, CHU Lariboisière, Universite Paris VII, France
    Stroke 31:1904-12. 2000
    ..Although chronic ischemia is presumed to cause the tissue lesions, the pattern of perfusion abnormalities and hemodynamic reserve in CADASIL, particularly within the white matter, remains unknown...
  71. ncbi The evaluation of radiolabeled artesunate on tissue distribution in rats and protein binding in humans
    Qigui Li
    Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland 20307, USA
    Am J Trop Med Hyg 75:817-26. 2006
    ..The radioactivity in whole blood was higher (two to fourfold) than that in plasma throughout the period of the treatment, suggesting that AS binding to RBCs may relate to its powerful antimalarial activity...
  72. ncbi Clinical and economic impact of a pharmacist-intervention to promote sequential intravenous to oral clindamycin conversion
    M J Martinez
    Department of Pharmacy, Meixoeiro Hospital, Pontevedra, Spain
    Pharm World Sci 22:53-8. 2000
    ..A sequential program with clindamycin may provide a cost-effective alternative to conventional therapy and the introduction of an information sheet is a cost-effective strategy to promote it...
  73. ncbi Lower-dose heparin with fibrinolysis is associated with lower rates of intracranial hemorrhage
    R P Giugliano
    TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Am Heart J 141:742-50. 2001
    ..The optimal heparin dose as an adjunct to fibrinolysis and its role in causing intracranial hemorrhage (ICH) is unclear...
  74. ncbi Long-term effects of intravenous high dose methylprednisolone pulses on bone mineral density in patients with multiple sclerosis
    M Zorzon
    Department of Clinical Medicine and Neurology, University of Trieste, Cattinara Hospital, Trieste, Italy
    Eur J Neurol 12:550-6. 2005
    ..BMD should be monitored in patients with MS, regardless of the use of methylprednisolone...
  75. ncbi Early switch from intravenous to oral antibiotics in hospitalized patients with bacteremic community-acquired Streptococcus pneumoniae pneumonia
    J A Ramirez
    Division of Infectious Diseases, Department of Medicine, University of Louisville, Louisville, KY 40292, USA
    Arch Intern Med 161:848-50. 2001
    ..The identification of Streptococcus pneumoniae bacteremia in hospitalized patients with community-acquired pneumonia is considered by some investigators to be an exclusion criterion for early switch from intravenous to oral therapy...
  76. ncbi Sodium ferric gluconate for post-transplant anemia in pediatric and young adult renal transplant recipients
    Robert S Gillespie
    Driscoll Children s Hospital, Corpus Christi, TX 78411, USA
    Pediatr Transplant 9:43-6. 2005
    ..Treatment with SFG appears to yield some improvement in anemia in renal transplant recipients, but the paucity of published information on this topic highlights the need for stronger data, particularly with respect to pediatric patients...
  77. ncbi Lipid-DNA complexes induce potent activation of innate immune responses and antitumor activity when administered intravenously
    S W Dow
    Division of Basic Immunology, Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 163:1552-61. 1999
    ..Thus, DNA complexed to cationic liposomes becomes highly immunostimulatory and capable of inducing strong antitumor activity when administered systemically...
  78. ncbi Pharmacokinetics and pharmacodynamics of danofloxacin in serum and tissue fluids of goats following intravenous and intramuscular administration
    F S Aliabadi
    Department of Veterinary Basic Sciences, The Royal Veterinary College, Hatfield, Hertfordshire, UK
    Am J Vet Res 62:1979-89. 2001
    ..CONCLUSIONS AND CLINICAL RELEVANCE: Integration of danofloxacin pharmacokinetic and pharmacodynamic data obtained in goats may provide a new approach on which to base recommendations for therapeutic dosages...
  79. ncbi Comparison of four strategies to reduce the pain associated with intravenous administration of rocuronium
    A B Chiarella
    Department of Anesthesiology and Pain Medicine, 3B2 32 Walter C Mackenzie Health Sciences Centre, University of Alberta Hospitals, 8440 112 Street, Edmonton, Alberta, Canada T6G 2B7
    Br J Anaesth 90:377-9. 2003
    ..I.V. rocuronium produces intense discomfort at the site of injection in conscious patients. Four strategies to reduce or prevent this discomfort were studied...
  80. ncbi Cerebral volume changes in multiple sclerosis patients treated with high-dose intravenous methylprednisolone
    E L J Hoogervorst
    Department of Neurology, VU Medical Center, Amsterdam, The Netherlands
    Mult Scler 8:415-9. 2002
    ..Multiple sderosis (MS) patients develop varying degrees of cerebral atrophy, which may already begin at disease onset The purpose of this study is to examine the effect of steroid treatment on cerebral volume in MS patients...
  81. ncbi Effects of IV methylprednisolone on brain atrophy in relapsing-remitting MS
    R Zivadinov
    Department of Clinical Medicine and Neurology, University of Trieste, Italy
    Neurology 57:1239-47. 2001
    ..Furthermore, there are no data on the impact of IVMP on T1 black holes or whole-brain atrophy...
  82. ncbi Assessment of myocardial reperfusion by intravenous myocardial contrast echocardiography and coronary flow reserve after primary percutaneous transluminal coronary angioplasty [correction of angiography] in patients with acute myocardial infarction
    W Lepper
    Medical Clinic I, University RWTH, Aachen, Germany
    Circulation 101:2368-74. 2000
    ....
  83. ncbi Clinical pharmacokinetics of norfloxacin-glycine acetate after intravenous and intramuscular administration to horses
    S C Park
    Veterinary Pharmacology and Toxicology Labs, College of Veterinary Medicine, Kyungpook National University, 702 701 Sangyeok dong, Buk Gu, Daegu, Republic of Korea
    Res Vet Sci 74:79-83. 2003
    ..36 and 7.35 mgkg(-1) for i.m. and i.v. administration, respectively...
  84. ncbi Dendritic cells injected via different routes induce immunity in cancer patients
    L Fong
    Department of Pathology, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    J Immunol 166:4254-9. 2001
    ..d. and two of six for i.l. routes. These results suggest that while activated DC can prime T cell immunity regardless of route, the quality of this response and induction of Ag-specific Abs may be affected by the route of administration...
  85. ncbi First-line oral capecitabine therapy in metastatic colorectal cancer: a favorable safety profile compared with intravenous 5-fluorouracil/leucovorin
    J Cassidy
    Department of Medicine and Therapeutics, University of Aberdeen, UK
    Ann Oncol 13:566-75. 2002
    ..In these trials, capecitabine achieved significantly superior response rates, equivalent time to disease progression and equivalent survival compared with 5-fluorouracil (5-FU)/leucovorin...
  86. ncbi Safety and effectiveness of intravenous morphine for episodic (breakthrough) pain using a fixed ratio with the oral daily morphine dose
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit, Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 27:352-9. 2004
    ..v.-M at a dose equivalent to 20% of the basal oral dosage is safe and effective in the majority of patients experiencing pain exacerbation. This treatment is inexpensive and can be used at little risk to patients...
  87. ncbi Patient preference and pharmacokinetics of oral modulated UFT versus intravenous fluorouracil and leucovorin: a randomised crossover trial in advanced colorectal cancer
    M M Borner
    Early Clinical Studies Group of The European Organization for Research and Treatment of Cancer, Belgium
    Eur J Cancer 38:349-58. 2002
    ..v. 5-FU/LV. Oral UFT/LV compares favourably with i.v. 5-FU/LV in terms of toxicity and patient's preference and leads to prolonged 5-FU exposure, which is comparable to continuous i.v. 5-FU treatment...
  88. ncbi Fatal air embolism in an extremely low birth weight infant: can it be caused by intravenous injections during resuscitation?
    Martin Wald
    University Children s Hospital, General Hospital of Vienna, University of Vienna, Wahringer Gurtel 18 20, 1090, Vienna, Austria
    Intensive Care Med 29:630-3. 2003
    ....
  89. ncbi Intravenous ibandronate reduces the incidence of skeletal complications in patients with breast cancer and bone metastases
    J J Body
    Universite Libre de Bruxelles, Institut Jules Bordet, Brussels, Belgium
    Ann Oncol 14:1399-405. 2003
    ..This phase III study compared the efficacy of the new potent bisphosphonate, ibandronate, with placebo as intravenous (i.v.) therapy in metastatic bone disease due to breast cancer...
  90. ncbi Pulmonary embolization of microcrystalline cellulose in a lung transplant recipient
    Timothy A Fields
    Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Heart Lung Transplant 24:624-7. 2005
    ....
  91. ncbi Intermittent intravenous ibandronate injections reduce vertebral fracture risk in corticosteroid-induced osteoporosis: results from a long-term comparative study
    J D Ringe
    Medizinische Klinik IV, Klinikum Leverkusen, University of Cologne, 51375 Leverkusen, Germany
    Osteoporos Int 14:801-7. 2003
    ..In conclusion, intermittent i.v. ibandronate injections are efficacious, well-tolerated, and convenient, and promise to offer physicians an important therapeutic advance in the management of osteoporosis...
  92. ncbi Intravenous fate of poly(2-(dimethylamino)ethyl methacrylate)-based polyplexes
    Ferry Verbaan
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, P O BOX 80082, 3508 TB, Utrecht, The Netherlands
    Eur J Pharm Sci 20:419-27. 2003
    ..This paper underlines the need for the design of systems with reduced interaction with blood components to promote the delivery of DNA to target tissues outside the lungs...
  93. ncbi Trastuzumab and liposomal Doxorubicin in the treatment of mcf-7 xenograft tumor-bearing mice: combination does not affect drug serum levels
    Dawn N Waterhouse
    BC Cancer Agency, USA
    Pharm Res 22:915-22. 2005
    ....
  94. ncbi Improving appropriateness of antibiotic therapy: randomized trial of an intervention to foster reassessment of prescription after 3 days
    Laurence Senn
    Division of Hospital Hygiene, University Hospital, Lausanne, Switzerland
    J Antimicrob Chemother 53:1062-7. 2004
    ..This study was conducted to evaluate the impact of a short questionnaire designed to encourage reassessment of intravenous antibiotic therapy after 3 days...
  95. ncbi Rectal and parenteral paracetamol, and paracetamol in combination with NSAIDs, for postoperative analgesia
    J Rømsing
    Department of Pharmaceutics, The Royal Danish School of Pharmacy, Copenhagen
    Br J Anaesth 88:215-26. 2002
    ....
  96. ncbi Considerations for optimal iron use for anemia due to chronic kidney disease
    J Q Hudson
    Department of Clinical Pharmacy, University of Tennessee, Memphis 38163, USA
    Clin Ther 23:1637-71. 2001
    ..Treatment guidelines for anemia management have been developed through the National Kidney Foundation Kidney Disease Outcomes Quality Initiative (NKF-K/DOQI)...
  97. ncbi Pharmacokinetics and metabolism of intravenous midazolam in preterm infants
    S N de Wildt
    Department of Pediatrics, Erasmus Medical Center Rotterdam, The Netherlands
    Clin Pharmacol Ther 70:525-31. 2001
    ..Midazolam, a benzodiazepine, is finding expanded use in neonatal intensive care units. We studied the pharmacokinetics and metabolism of midazolam after a single intravenous dose in preterm infants...
  98. ncbi The impact of the optic neuritis treatment trial on the practices of ophthalmologists and neurologists
    J D Trobe
    Department of Ophthalmology, W K Kellogg Eye Center, School of Medicine, University of Michigan, Ann Arbor 48105, USA
    Ophthalmology 106:2047-53. 1999
    ..To determine whether the Optic Neuritis Treatment Trial (ONTT) results have altered the practice patterns of ophthalmologists and neurologists...
  99. ncbi Intravenous iron in a primary-care clinic
    I Maslovsky
    Department of Internal Medicine, Barzilai Medical Center, Ashkelon, Israel
    Am J Hematol 78:261-4. 2005
    ..One case of dropout occurred, due to the patient's refusal to cooperate. No anaphylactic reactions were observed. Iron gluconate and iron sucrose are effective and safe for use in primary care clinics. The risk of adverse effects is low...
  100. ncbi Intravenous contrast material administration at helical 16-detector row CT coronary angiography: effect of iodine concentration on vascular attenuation
    Filippo Cademartiri
    Department of Radiology, Erasmus Medical Center, Dr Molewaterplein 40, 3015GD Rotterdam, The Netherlands
    Radiology 236:661-5. 2005
    ..The same pattern was observed in the coronary arteries. Contrast materials with higher iodine concentrations yield significantly higher attenuation in the descending aorta and coronary arteries...
  101. ncbi Rapid administration of ibandronate does not affect renal functioning: evidence from clinical studies in metastatic bone disease and hypercalcaemia of malignancy
    M Pecherstorfer
    First Department of Medicine and Oncology, Wilhelminenspital, Montleartstrasse 37, 1171, Vienna, Austria
    Support Care Cancer 12:877-81. 2004
    ..Implications for the renal safety of ibandronate in the management of patients with metastatic bone disease are discussed...

Research Grants62

  1. Targeted EGFR Antisense Gene Therapy of Brain Cancer
    RUBEN BOADO; Fiscal Year: 2005
    ..delivery technology employs pegylated immunoliposomes (PILs) and is non-invasive, requiring only weekly intravenous injections. The PIL gene transfer technology will be combined with the power of antisense mechanisms to develop new ..
  2. Prevention and Treatment of Chlorine Gas Induced Injury to the Pulmonary System
    Sadis Matalon; Fiscal Year: 2011
    ..5, 6, 12, 24 and 48 h post exposure. These measurements will be repeated following intravenous injections of NAC, ascorbate and deferoxamine as well as albuterol and the tip peptide, every 6 h post exposure for ..
  3. Mechanisms of IGF-1 mediated rescue of radiation-induced salivary gland dysfuncti
    Kirsten H Limesand; Fiscal Year: 2012
    ..b>Intravenous injections of recombinant IGF1 prior to radiation exposure completely rescues salivary flow rates 30 days after ..
  4. Substrate Optimization Therapy: A Novel Therapy for Mucopolysaccharidosis
    CHARLES ALEXANDER GLASS; Fiscal Year: 2010
    ..MPS II is a rare genetic disease that is currently only partially managed through weekly intravenous injections. Through this grant we aim to identify compounds that are the crucial starting point for the development ..
  5. Substrate Optimization Therapy: A Novel Therapy for Mucopolysaccharidosis
    CHARLES ALEXANDER GLASS; Fiscal Year: 2012
    ..a collection of rare childhood genetic diseases that are currently only partially managed through weekly intravenous injections that do not treat the neurological deficits arising from the diseases...
  6. 4D DSA and 4D Fluoroscopy: Validation of Diagnostic and Therapeutic Capabilities
    Charles Milton Strother; Fiscal Year: 2013
    ..purposes while other angiographic modalities such as CTA and MRA have been used in connection with intravenous injections. Although current 3D rotational DSA does provide a 3D reconstruction, the images contain no temporal ..
  7. Versatile carriers for cell-specific siRNA delivery in vivo
    Priti Kumar; Fiscal Year: 2012
    ..Importantly, delivery to the target cell type/organ will be achieved through simple intravenous injections. We will generate siRNA carriers to each of the human immune cell subtypes and defined organs/tissues and ..
  8. Radiological Biomarkers for Frontotemporal Lobar Degeneration
    KYLE BYRON WOMACK; Fiscal Year: 2011
    ..short MRI sequence that can be added onto the standard sequences in a clinical MRI, and requires no intravenous injections or exposure to radiation...
  9. ISOFORMS OF CREATINE KINASE--MYOCARDIAL INFARCATION
    Dana Abendschein; Fiscal Year: 1991
    ..Separate intravenous injections of purified isoforms in conscious dogs with and without concomitant inhibition of plasma isoform ..
  10. MECHANISM OF TREATMENT COMPLICATIONS IN PARKINSONS
    Robert Schwartzman; Fiscal Year: 1991
    ..Twenty two monkeys will be made parkinsonian by intravenous injections of MPTP. Eight animals will be used as controls...
  11. CARDIAC OUTPUT MONITOR FOR CHILDREN'S ICU & SURGERY
    Nikolai Krivitski; Fiscal Year: 2000
    ..Transonic Systems flow/dilution sensor is clipped-onto external tubing, intravenous injections of isotonic saline are performed, and blood is returned to the patient upon completion...
  12. FUNCTIONAL STUDIES OF MPS VII MICE AFTER ENZYME THERAPY
    Mark Sands; Fiscal Year: 2000
    ..We demonstrated that intravenous injections of phosphorylated beta-glucuronidase started at birth resulted in relatively high levels of enzyme in the ..
  13. REGULATION OF VIRAL INFECTIVITY
    WILLIAM CAFRUNY; Fiscal Year: 1991
    ..Uninfected mice will receive intravenous injections of anti-LDV antibodies, or will be immunized with allogeneic macrophages prior to live virus exposure in ..
  14. THE DEVELOPMENTAL NEUROCHEMISTRY OF COCAINE
    Susan Robinson; Fiscal Year: 1992
    ..Pregnant females will receive either intravenous injections of various doses of cocaine or saline or no treatment in pregnancy during prenatal development of ..
  15. Mechanistic Studies on Polymeric Controlled Oral Gene
    Kam Leong; Fiscal Year: 2007
    ..nature of gene expression, non-viral gene therapy would necessitate frequent administration by muscular or intravenous injections, the common routes for non-viral in vivo gene transfer...
  16. Amphetamine Sensitization: Role of Dopamine Transporters
    JOSHUA GULLEY; Fiscal Year: 2003
    ..Measurements will be made in untreated rats and those withdrawn from daily intravenous injections of saline or amphetamine (AMPH)...
  17. Augementing Peptide-specific Tolerance in ImmuneNephrit*
    Ram Singh; Fiscal Year: 2005
    ..Th cell tolerance induction, however, are cumbersome and expensive, as they require multiple intravenous injections of large doses of antigenic peptides; such approaches usually confer a limited and short-lasting ..
  18. Prion Transport Across the Blood-Brain Barrier
    William Banks; Fiscal Year: 2009
    ..To cause disease, prions must cross the blood-brain barrier to enter the brain. We will determine how prions cross the BBB. Knowing how prions enter the brain should lead to strategies on how to prevent prion diseases. ..
  19. Biomaterials as Decorporation Agents for Radionuclides
    TATIANA LEVITSKAIA; Fiscal Year: 2008
    ..abstract_text> ..
  20. Opiate Addiction and HIV-1 Induced Release of Cytokines
    William Banks; Fiscal Year: 2006
    ....
  21. GABA Medications for Tobacco Addiction
    Mehmet Sofuoglu; Fiscal Year: 2009
    ..The findings of this study will provide valuable information to develop new pharmacotherapies for smoking cessation. ..
  22. Progestrone and the Effects of Nicotine
    Mehmet Sofuoglu; Fiscal Year: 2006
    ..By characterizing the progesterone effects on nicotine dependence, this study may provide a better understanding of the mechanisms which mediate the sex and menstrual cycle phase effects on nicotine dependence. ..
  23. Cocaine Withdrawal and Pharmacotherapy Response
    Mehmet Sofuoglu; Fiscal Year: 2010
    ..This proposal, by testing the efficacy of carvedilol and investigating the influence of withdrawal severity on carvedilol's efficacy, may result in development of more effective treatments for cocaine addiction. ..
  24. Mechanisms of HIV Transport Across the BBB
    William Banks; Fiscal Year: 2004
    ....
  25. PTS1 Regulation of Brain Met Enk Levels in Alcoholism
    William Banks; Fiscal Year: 2004
    ..abstract_text> ..
  26. Primate Model of the Transition to Cocaine Addiction
    JAMES ROWLETT; Fiscal Year: 2005
    ..The results will provide needed information for developing a nonhuman primate model that can serve as a quantitative platform for future research on neuroadaptations underlying the transition to persistent cocaine self-administration. ..
  27. Nitric Oxide Precursors and Congenital Heart Surgery
    Frederick Barr; Fiscal Year: 2008
    ....
  28. Nonhuman Primate Model of Benzodiazepine Relapse
    JAMES ROWLETT; Fiscal Year: 2002
    ....
  29. Novel direct vago-vagal recording of i.v. ghrelin action
    David Adelson; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  30. New MRI techniques for cerebrovascular diseases
    Gregory Albers; Fiscal Year: 2008
    ..This K24 research program will expand Dr. Albers' skills as a clinical investigator and allow him to become a more effective mentor. [unreadable] [unreadable]..
  31. ANESTHETIC RENAL METABOLISM--MECHANISMS AND CONSEQUENCES
    Evan Kharasch; Fiscal Year: 2002
    ..More broadly, resulting biochemical and clinical insights will be applicable to the numerous other nephrotoxic haloalkenes that are ubiquitous environmental contaminants. ..
  32. Novel noninvasive assessment of cytochrome P450 activity
    Evan Kharasch; Fiscal Year: 2009
    ..This approach may identify inter-individual variability in drug disposition and response;permit more individualized dosing, and reduces the cost of drug interaction studies. ..
  33. Diffusion weighted imaging Evaluation For Understanding Stroke Evolution2:DEFUSE
    Gregory W Albers; Fiscal Year: 2010
    ..These findings will eventually lead to effective therapies for a large population of stroke patients who are currently ineligible for treatment and substantially reduce stroke-related disability. ..
  34. Long Field Of View MRA Using Continuous Table Motion
    Stephen Riederer; Fiscal Year: 2008
    ..Eventually this process will be performed using the full contrast bolus alone. ..
  35. Role of Multidrug Resistance Proteins 2 and/or 4, and DMPS and DMSA in the Renal
    CHRISTY BRIDGES; Fiscal Year: 2008
    ..These data will serve as the basis for the development of additional treatments for mercury poisoning. [unreadable] [unreadable] [unreadable] [unreadable]..
  36. NMDA Receptor Dynamics After Brain Injury
    Anat Biegon; Fiscal Year: 2011
    ..The results may explain the failure of NMDAR antagonists in clinical trials and suggest novel strategies for treatment of brain injury. ..
  37. Cannabinoid Receptor Function in Alcoholism: Effects of D-9-THC
    DEEPAK D SOUZA; Fiscal Year: 2008
    ..These results may reflect indirect evidence of altered CB-1R function in FHP individuals. [unreadable] [unreadable] [unreadable]..
  38. Adult Stem Cells for Repair of Cardiac Damage
    DARWIN JOHNSON PROCKOP; Fiscal Year: 2010
    ..The present application is to extend this work and to capitalize an unexpected discovery that it may justify infusing therapeutic intravenously, a much more attractive route for therapy than injection into the heart. ..
  39. Non-Viral Gene Targeting to the Brain
    William Pardridge; Fiscal Year: 2008
    ..abstract_text> ..
  40. PERIAQUEDUCTAL GRAY MODULATION OF SYMPATHETIC DRIVE
    Linda Hayward; Fiscal Year: 2002
    ..In the long term it is hoped that the results of these studies will stimulate new investigations into the role of the dlPAG, A5 and the PBN in normal and pathophysiological cardiovascular regulation. ..
  41. PROGRESSION OF AORTIC ATHEROMA IN STROKE/TIA PATIENTS
    Souvik Sen; Fiscal Year: 2004
    ..Designing of future placebo controlled prospective studies aimed at investigating measures that may be used to treat AA in stroke/TIA patients. ..
  42. Metallothionein in Chronic Alcoholic Liver Injury
    Zhanxiang Zhou; Fiscal Year: 2004
    ..These studies will provide fundamental understanding of the role and possible clinical application of MT in cytoprotection against chronic alcohol-induced liver injury, a major clinical health problem without FDA approved therapy. ..
  43. Impact of Aging on Stroke Care: A National Perspective
    Judith Lichtman; Fiscal Year: 2004
    ..We hypothesize that variations in care exist by age. Moreover, these differences in care will not be explained by differences clinical features or co-morbid conditions associated with aging. ..
  44. Neuroadaptations underlying the transition to addiction.
    Osnat Ben Shahar; Fiscal Year: 2006
    ..Together, these experiments will illuminate some of the changes in dopaminergic function that underlie the transition to compulsive drug-use. ..
  45. Sex steroid, HPA regulation, and fat patterning
    Jonathan Purnell; Fiscal Year: 2003
    ..abstract_text> ..
  46. Brain Connections
    Michelle Petri; Fiscal Year: 2006
    ..abstract_text> ..
  47. Peroxynitrite decomposition catalyst:diabetic neuropathy
    IRINA OBROSOVA; Fiscal Year: 2006
    ..abstract_text> ..
  48. Quantitation of Early Vascular Leakage after Stroke
    Patrick Lyden; Fiscal Year: 2006
    ..3. Validate that FITC-dextran blood brain barrier breakdown correlates with in vivo measures of low blood flow in microvessels. ..
  49. Cardiopulmonary Exercise Testing: Pulmonary Hypertension
    Ronald Oudiz; Fiscal Year: 2007
    .._l.Center. PHS 398/2590(Rev.05/01) Page _, LJ ContinuationFormatPage NumberpagesconsecutivelyatthebottomthroughoutheapplicationD. o no_u_stesuffixesuchas3a, 3b. ..
  50. Vulnerability to Smallpox Due to Declining CTL Immunity
    Innocent Mbawuike; Fiscal Year: 2003
    ..By correlating these responses with vaccinia lesion sizes in new vaccinees, markers of severe complications from vaccinia vaccination may be identified. ..
  51. Supramedullary control of respiration
    Linda Hayward; Fiscal Year: 2007
    ..Furthermore, the results of this study will provide new insights into understanding of the role of supramedullary structures in modulating respiratory timing. [unreadable] [unreadable]..
  52. Non-Viral Vectors for Liver Gene Transfer
    Feng Liu; Fiscal Year: 2006
    ..The therapeutic effects on the metabolic disease on phenylketonuria (PKU) mice, will be examined after the PAH gene transfer using the approach in this proposal. ..
  53. GAS CHROMATOGRAPH MASS SPECTROMETER
    Scott Denne; Fiscal Year: 2004
    ..Finally, a new and more efficient instrument will facilitate the ability of other investigators across the campus to use the laboratory. ..
  54. PATIENT ORIENTED RESEARCH--ORAL AND MAXILLOFACIAL SURGER
    THOMAS DODSON; Fiscal Year: 2004
    ..This award leverages the PI's skills and talents by providing protected time to mentor additional trainees and to conduct high quality patient-oriented research. ..
  55. Controlled Delivery System for Naltrexone
    EMMANUEL AKALA; Fiscal Year: 2004
    ....
  56. PET AND MRI IMAGING OF PERSISTENT LYME ENCEPHALOPATHY
    Brian Fallon; Fiscal Year: 2003
    ..This study will enhance our understanding of the pathophysiology and treatment of patients suffering with the disabling effects of persistent Lyme encephalopathy. ..
  57. Abuse-Related Effects of Opioids and Adjuvant Drug Used by Chronic Pain Patients
    James P Zacny; Fiscal Year: 2010
    ..g., muscle relaxant B) would be the preferred drug to prescribe when treating chronic nonmalignant pain patients. ..
  58. Zinc and Alcohol-Induced Oxidative Liver Injury
    Zhanxiang Zhou; Fiscal Year: 2009
    ..These studies will provide fundamental understanding of the role of zinc in the pathophysiology of ALD, and pave the way to novel therapeutical approaches to prevention and treatment of this disease. ..
  59. Revision of ACR Classification Criteria for Systemic Lupus Erythematosus
    Michelle Petri; Fiscal Year: 2007
    ..This project will lead to updated, validated SLE classification criteria that can be immediately used by both industry and academic clinical trials. ..
  60. CB-1 Antagonists for Cannabis Addiction
    Jack Bergman; Fiscal Year: 2008
    ..Overall, our proposed studies will permit highly significant progress toward the development of novel antagonist-based medications to combat the addictive power of delta9THC. ..
  61. Microarray analysis of morphine's behavioral effects
    GREGORY ELMER; Fiscal Year: 2007
    ..abstract_text> ..
  62. Transport of TNFalpha across the BBB
    Weihong Pan; Fiscal Year: 2008
    ..These transporters could be novel drug targets and therefore provide promising therapeutic potential. [unreadable] [unreadable]..