intralymphatic injections

Summary

Summary: Injections into the lymph nodes or the lymphatic system.

Top Publications

  1. ncbi Intralymphatic immunotherapy: from the rationale to human applications
    Gabriela Senti
    Clinical Trials Center, Center for Clinical Research, University and University Hospital of Zurich, Ramistrasse 100, 8091 Zurich, Switzerland
    Curr Top Microbiol Immunol 352:71-84. 2011
  2. ncbi Intralymphatic injections as a new administration route for allergen-specific immunotherapy
    Julia M Martínez-Gómez
    Unit for Experimental Immunotherapy, Department of Dermatology, University Hospital of Zurich, Zurich CH 8091, Switzerland
    Int Arch Allergy Immunol 150:59-65. 2009
  3. ncbi [Surgical strategy in oncologic diseases of organs of the pancreatobiliary zone complicated by mechanical jaundice]
    I V Iarema
    Vestn Khir Im I I Grek 162:27-30. 2003
  4. ncbi [Efficacy of activated charcoal-epirubicin suspension for treatment of breast cancer with axillary metastasis]
    Wu jun Wu
    Department of General Surgery, First Hospital of Xi an Jiaotong University, Xi an 710061, China
    Nan Fang Yi Ke Da Xue Xue Bao 26:1812-4. 2006
  5. ncbi IVN201--therapy with a construct containing functional fusion peptides
    Horst Rose
    ImVisioN GmbH, Hannover
    Arb Paul Ehrlich Inst Bundesinstitut Impfstoffe Biomed Arzneim Langen Hess 96:319-27; discussion 327-8. 2009
  6. pmc Intraocular lymphoma: update on diagnosis and management
    Chi Chao Chan
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cancer Control 11:285-95. 2004
  7. ncbi Intralymphatic allergen-specific immunotherapy: an effective and safe alternative treatment route for pollen-induced allergic rhinitis
    Terese Hylander
    Department of Clinical Sciences, Intervention and Technology, Division of ENT Diseases, Karolinska Institutet, Stockholm, Sweden
    J Allergy Clin Immunol 131:412-20. 2013
  8. ncbi Lymph node targeting of BCG vaccines amplifies CD4 and CD8 T-cell responses and protection against Mycobacterium tuberculosis
    Ying Waeckerle-Men
    Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland
    Vaccine 31:1057-64. 2013
  9. ncbi Immunologic and clinical effects of injecting mature peptide-loaded dendritic cells by intralymphatic and intranodal routes in metastatic melanoma patients
    Thierry Lesimple
    Centre Eugene Marquis, Rennes, France
    Clin Cancer Res 12:7380-8. 2006
  10. ncbi [Complex therapy of acute and exacerbated chronic nonspecific parotitis including mexidol and non-coherent infrared therapy]
    E I Deriabin
    Stomatologiia (Mosk) 85:21-3. 2006

Research Grants

  1. FAS LIGAND GENE TRANSFER IN ARTHRITIS
    Youhai Chen; Fiscal Year: 2001
  2. COSTIMULATION IN MUCOSAL IMMUNITY AND TOLERANCE
    Youhai Chen; Fiscal Year: 2002
  3. AUTOIMMUNE ENCEPHALOMYELITIS AND NF-KB
    Youhai Chen; Fiscal Year: 2003
  4. IL-6 IN AUTOIMMUNE ENCEPHALOMYELITIS
    Youhai Chen; Fiscal Year: 2003
  5. Discovery and functional assessment of the rat op gene
    DAVID DOBBINS; Fiscal Year: 2004
  6. Autoimmune Encephalomyelitis and p53
    Youhai Chen; Fiscal Year: 2006
  7. Autoimmune Encephalomyelitis and TRAIL
    Youhai Chen; Fiscal Year: 2007
  8. Type I diabetes and TRAIL
    Youhai Chen; Fiscal Year: 2007
  9. Autoimmune encephalomyelitis and Bcl-2- interacting mediator
    Youhai H Chen; Fiscal Year: 2010

Scientific Experts

Detail Information

Publications72

  1. ncbi Intralymphatic immunotherapy: from the rationale to human applications
    Gabriela Senti
    Clinical Trials Center, Center for Clinical Research, University and University Hospital of Zurich, Ramistrasse 100, 8091 Zurich, Switzerland
    Curr Top Microbiol Immunol 352:71-84. 2011
    ..b>Intralymphatic injections proved easy, practically painless and safe...
  2. ncbi Intralymphatic injections as a new administration route for allergen-specific immunotherapy
    Julia M Martínez-Gómez
    Unit for Experimental Immunotherapy, Department of Dermatology, University Hospital of Zurich, Zurich CH 8091, Switzerland
    Int Arch Allergy Immunol 150:59-65. 2009
    ..To improve the safety and attractiveness of SIT for patients, alternative routes of allergen administration are being explored, such as sub-lingual or oral administration...
  3. ncbi [Surgical strategy in oncologic diseases of organs of the pancreatobiliary zone complicated by mechanical jaundice]
    I V Iarema
    Vestn Khir Im I I Grek 162:27-30. 2003
    ..It allowed twice as quick to arrest the inflammatory process in the bile ducts, to normalize the biochemical indices of blood, and to prepare the patient for the main stage of operation...
  4. ncbi [Efficacy of activated charcoal-epirubicin suspension for treatment of breast cancer with axillary metastasis]
    Wu jun Wu
    Department of General Surgery, First Hospital of Xi an Jiaotong University, Xi an 710061, China
    Nan Fang Yi Ke Da Xue Xue Bao 26:1812-4. 2006
    ..To investigate the effect of activated charcoal-epirubicin suspension (Epi-CH) for treatment of breast cancer and clearance of axillary lymph node metastasis...
  5. ncbi IVN201--therapy with a construct containing functional fusion peptides
    Horst Rose
    ImVisioN GmbH, Hannover
    Arb Paul Ehrlich Inst Bundesinstitut Impfstoffe Biomed Arzneim Langen Hess 96:319-27; discussion 327-8. 2009
    ..Patients subjectively perceived the intralymphatic injections less painful than a venous puncture...
  6. pmc Intraocular lymphoma: update on diagnosis and management
    Chi Chao Chan
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cancer Control 11:285-95. 2004
    ..The incidence of this previously rare condition has increased dramatically. Given its nonspecific presentation and aggressive course, PIOL provides a diagnostic and therapeutic challenge...
  7. ncbi Intralymphatic allergen-specific immunotherapy: an effective and safe alternative treatment route for pollen-induced allergic rhinitis
    Terese Hylander
    Department of Clinical Sciences, Intervention and Technology, Division of ENT Diseases, Karolinska Institutet, Stockholm, Sweden
    J Allergy Clin Immunol 131:412-20. 2013
    ..Recent evidence suggests that direct intralymphatic injections could yield faster beneficial results with considerably lower allergen doses and markedly reduced ..
  8. ncbi Lymph node targeting of BCG vaccines amplifies CD4 and CD8 T-cell responses and protection against Mycobacterium tuberculosis
    Ying Waeckerle-Men
    Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland
    Vaccine 31:1057-64. 2013
    ..C57BL/6 mice were immunised with BCG by intradermal, subcutaneous or intralymphatic injections. Cellular immune responses and protection against M. tuberculosis were determined...
  9. ncbi Immunologic and clinical effects of injecting mature peptide-loaded dendritic cells by intralymphatic and intranodal routes in metastatic melanoma patients
    Thierry Lesimple
    Centre Eugene Marquis, Rennes, France
    Clin Cancer Res 12:7380-8. 2006
    ..A phase I/II trial was conducted to evaluate clinical and immunologic responses after intralymphatic and intranodal injections of mature dendritic cells...
  10. ncbi [Complex therapy of acute and exacerbated chronic nonspecific parotitis including mexidol and non-coherent infrared therapy]
    E I Deriabin
    Stomatologiia (Mosk) 85:21-3. 2006
    ....
  11. ncbi Antigen challenge inhibits thymic emigration
    Adam P Uldrich
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
    J Immunol 176:4553-61. 2006
    ..Thus, in addition to its accepted role in intrathymic selection events, TCR signaling can also play an important role in the regulation of thymic emigration...
  12. ncbi [Impact of preoperative lymphatic chemotherapy on relapse and metastasis of breast cancer and its mechanism]
    Wu jun Wu
    Department of Gastrointestinal and Glands Surgery, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, P R China
    Ai Zheng 24:1537-41. 2005
    ..This study was to explore the impact of lymphatic chemotherapy on relapse and metastasis of breast cancer, and to investigate the mechanism...
  13. pmc Replication and propagation of attenuated vesicular stomatitis virus vectors in vivo: vector spread correlates with induction of immune responses and persistence of genomic RNA
    Ian D Simon
    Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06510, USA
    J Virol 81:2078-82. 2007
    ..Such persistence may be important for induction of potent immune responses by VSV vectors...
  14. ncbi [Effect of preoperative lymphatic chemotherapy on Bcl-2 and Bax expression in axillary metastasis of breast cancer]
    Wu jun Wu
    Department of General Surgery, First Hospital of Xi an Jiaotong University, Xi an 710061, China
    Di Yi Jun Yi Da Xue Xue Bao 25:1001-4. 2005
    ....
  15. ncbi Dendritic-cell-based therapeutic vaccination against cancer
    Frank O Nestle
    Department of Dermatology, University Hospital of Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland
    Curr Opin Immunol 17:163-9. 2005
    ..This explains the current need for innovative well designed trials with defined endpoints that induce robust anti-tumor immunity...
  16. ncbi Direct intralymphatic injection of peptide vaccines enhances immunogenicity
    P Johansen
    Department of Dermatology, University of Zurich, Zurich, Switzerland
    Eur J Immunol 35:568-74. 2005
    ..These results should have immediate implications for clinical immunotherapy of infectious disease and cancer...
  17. ncbi Reevaluation of bone marrow-derived cells as a source for hepatocyte regeneration
    Tobias Cantz
    Laboratory of Cell and Gene Therapy, Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Cell Transplant 13:659-66. 2004
    ..Thus, potential therapeutic prospects of hematopoietic stem cell therapy for liver disease have to be critically reassessed...
  18. ncbi Endolymphatic infusion: human surgical investigation and application
    S Petrov
    Department of Surgery, St Petersburg State University, St Petersburg, Russia
    Lymphat Res Biol 1:75-9; discussion 79-80. 2003
    ..Based on our initial observations, we have applied endolymphatic infusion to clinical care. ELI was evaluated in the treatment of 330 patients, utilizing protocols to alter the characteristics of lymph flow...
  19. ncbi Intralabyrinthine fluid dynamics: Meniere disease
    James C Andrews
    Division of Head and Neck Surgery, Sepulveda UCLA Veterans Administration Hospital, 16111 Plummer Street, Sepulveda, CA 91343, USA
    Curr Opin Otolaryngol Head Neck Surg 12:408-12. 2004
    ..Meniere disease has long been postulated to be a disorder of intralabyrinthine fluid dynamics...
  20. ncbi Comparison of intranasal with targeted lymph node immunization using PR8-Flu ISCOM adjuvanted HIV antigens in macaques
    G Koopman
    Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    J Med Virol 79:474-82. 2007
    ..In conclusion, in contrast to what has been demonstrated in mice, the IN application of PR8-Flu ISCOM did not induce strong immune responses in rhesus macaques unlike those immunized by the TLNI route...
  21. ncbi Phase I study of tumor Ag-loaded IL-12 secreting semi-mature DC for the treatment of pediatric cancer
    A M Dohnal
    Children s Cancer Research Institute, St Anna Children s Hospital, Vienna, Austria
    Cytotherapy 9:755-70. 2007
    ..IL-12, a cytokine critical for type 1 T-helper (Th1) lymphocyte and cytotoxic T-lymphocyte (CTL) differentiation, when released from a DC-based cancer vaccine, may support the generation of a cellular T-cell response...
  22. ncbi Targeted introduction of substances into the lymph nodes for endolymphatic therapy
    Peter Hirnle
    Central Academic Hospital, Department of Radiation Oncology, Bielefeld, Germany
    Cancer Treat Res 135:101-18. 2007
  23. ncbi Sclerotherapy with bleomycin does not adversely affect facial nerve function in children with cervicofacial cystic lymphatic malformation
    Afra Karavelioğlu
    Department of Pediatric Surgery, Hacettepe University Faculty of Medicine, Ankara 06100, Turkey
    J Pediatr Surg 45:1627-32. 2010
    ..The authors conducted a clinical experimental study to evaluate facial nerve function in children who have undergone BS sclerotherapy for cervicofacial cystic lymphatic malformation...
  24. ncbi Dendritic cell-based vaccines for the therapy of experimental tumors
    Elzbieta Pajtasz-Piasecka
    Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland
    Immunotherapy 2:257-68. 2010
    ..In this article, the perspectives of DC-based anti-tumor immunotherapy and optimizing strategies of DC vaccination in humans in light of results obtained in mouse models are discussed...
  25. pmc Effect of artificial endolymph injection into the cochlear duct on perilymph potassium
    Akinobu Kakigi
    Department of Otolaryngology, Faculty of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    ORL J Otorhinolaryngol Relat Spec 71:16-8. 2010
    ..To investigate the relationship between endolymphatic hydrops and perilymphatic potassium...
  26. pmc Pharmacokinetics and disposition of a localized lymphatic polymeric hyaluronan conjugate of cisplatin in rodents
    Shuang Cai
    Department of Pharmaceutical Chemistry, University of Kansas, 2095 Constant Ave, Lawrence, Kansas 66047, USA
    J Pharm Sci 99:2664-71. 2010
    ..In addition, localized particle delivery augmented distribution in the loco-regional tissue basin where tumor burden predominates, while renal toxicity compared to standard intravenous CDDP was significantly reduced...
  27. ncbi Sclerotherapy of branchial cleft cysts using OK-432
    Myung Gu Kim
    Department of Otorhinolaryngology Head and Neck Surgery, Masan Samsung Hospital, Seoul, Korea
    Otolaryngol Head Neck Surg 141:329-34. 2009
    ..We conducted this study to evaluate the effectiveness of sclerotherapy using OK-432 in treatment of BCC...
  28. ncbi Simultaneous evaluation of portal hemodynamics and liver function by scintiphotosplenoportography in pediatric recipients of living-donor liver transplants
    Hiroshi Yoshida
    Department of Surgery, Nippon Medical School, Tokyo, Japan
    Hepatogastroenterology 56:819-23. 2009
    ....
  29. ncbi New ectopic vestibular hair cell-like cells induced by Math1 gene transfer in postnatal rats
    Yibo Huang
    Department of Otorhinolaryngology, Eye, Ear, Nose and Throat Hospital, Fudan University, 83 Fen Yang Road, Shanghai 200031, People s Republic of China
    Brain Res 1276:31-8. 2009
    ..Our study might pave the way for further in vivo studies on vestibular Math1 adenoviral vector gene transfer...
  30. ncbi Clinical grade OK432-activated dendritic cells: in vitro characterization and tracking during intralymphatic delivery
    Emma West
    Cancer Research UK Clinical Centre, Leeds Institute of Molecular Medicine, Leeds Teaching Hospitals NHS Trust, St James s University Hospital Leeds, UK
    J Immunother 32:66-78. 2009
    ..These results show that OK-DC are suitable for clinical use, and that intralymphatic delivery is feasible for localizing cells to sites where optimal priming of innate and adaptive antitumor immunity is likely to occur...
  31. pmc Intralymphatic allergen administration renders specific immunotherapy faster and safer: a randomized controlled trial
    Gabriela Senti
    Unit for Experimental Immunotherapy, Department of Dermatology, University Hospital Zurich, 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 105:17908-12. 2008
    ..pollen extract over 3 years [cumulative allergen dose 4,031,540 standardized quality units (SQ-U)] or 3 intralymphatic injections over 2 months (cumulative allergen dose 3,000 SQ-U)...
  32. ncbi Endolymphatic immunotherapy in inoperable hepatocellular carcinoma
    R Bertelli
    Department of General Surgery and Transplantations, S Orsola Malpighi Hospital, University of Bologna, Bologna, Italy
    Transplant Proc 40:1913-5. 2008
    ..We report the preliminary results of endolymphatic immunotherapy in patients with inoperable hepatocellular carcinoma (HCC)...
  33. ncbi Definitive identification of a patent processus vaginalis by intraoperative injection of methylene blue into the hydrocoele sac
    John G Calleary
    Department of Urology, Harold Wood Hospital, Gubbins Lane, Romford, Essex RM3 0BE, UK
    J Pediatr Urol 4:218-20. 2008
    ..We report a modification of a technique to improve identification of the PPV and thus potentially minimise the risk to the cord...
  34. pmc Intralymphatic chemotherapy using a hyaluronan-cisplatin conjugate
    Shuang Cai
    Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, Kansas, USA
    J Surg Res 147:247-52. 2008
    ..The purpose of this study is to determine whether lymphatically targeted cisplatin carriers will increase the localized dose in lymphatic metastases without systemic toxicities...
  35. ncbi Characterization of the in vivo dynamics of medullary CD4+CD8- thymocyte development
    Rong Jin
    Department of Immunology, Peking University Health Science Center, 38 Xue Yuan Road, Beijing, China
    J Immunol 180:2256-63. 2008
    ..Collectively, these data not only provide solid evidence for a highly ordered differentiation program for CD4SP thymocytes, but they also illustrate several important features associated with the developmental process...
  36. ncbi Rationale for superficial injection techniques in lymphatic mapping in breast cancer patients
    Omgo E Nieweg
    Department of Surgery, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    J Surg Oncol 87:153-6. 2004
    ..Tracer administration close to the tumor site appears to be the safest approach for the time being. Excellent results can be obtained with this latter approach, despite the fact that it is technically more demanding...
  37. ncbi [Preparation of lymphatic targeting dosage form: pingyangmycin absorbed on activated carbon nanoparticles]
    Ming Lei Sun
    Dept of Stomatology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China
    Hua Xi Kou Qiang Yi Xue Za Zhi 22:183-5. 2004
    ..To prepare anticancer nanoparticles for targeting therapy for oral cancer lymph node metastasis...
  38. ncbi Targeted lymph node immunization can protect cats from a mucosal challenge with feline immunodeficiency virus
    S Finerty
    Department of Clinical Veterinary Science, University of Bristol, Langford, BS40 5DU, Bristol, UK
    Vaccine 20:49-58. 2001
    ..Vaccination with fixed virus infected cells elicited protection against a cell-free mucosal FIV challenge. In addition, some cats vaccinated with fixed uninfected cells also remained uninfected following a cell-associated FIV challenge...
  39. ncbi Cytokine deviation induced by intrathymic injection of staphylococcal enterotoxin B (SEB)
    P Goettelfinger
    Laboratoire de Physiologie Thymique, Centre Chirurgical Marie-Lannelongue, , 133, , 92350 Le Plessis-Robinson, France
    Eur Cytokine Netw 12:487-500. 2001
    ..Moreover, it highlights the crucial role of the route of SEB injection in the pattern of cytokine expression...
  40. ncbi [Pathologic morphology of cervical carcinoma with endolymphatic infusion of immuno-modulating drugs]
    L Ia Rozenko
    Research Institute of Oncology, Ministry of Health of the RF, Rostov-on-Don
    Vopr Onkol 47:315-20. 2001
    ..Also, the treatment was supplemented with regional infusion of considerable doses of cytostatic mixes. Our morphological evidence pointed to the stimulation of cytostatic effect by immunomodulation...
  41. ncbi Immunization with Staphylococcus aureus lysate incorporated into microspheres
    C N O'Brien
    Immunology and Disease Resistance Laboratory, USDA, Beltsville, MD 20705, USA
    J Dairy Sci 84:1791-9. 2001
    ..aureus adherence to mammary epithelium. Ability to control antigen release and presentation, and the benefit of a single injection for long-term immunity using microspheres warrants additional studies...
  42. ncbi Mechanisms of the antimetastatic effect in the liver and of the hepatocyte injury induced by alpha-galactosylceramide in mice
    R Nakagawa
    Pharmaceutical Research Laboratory, Kirin Brewery Company, Takasaki, Japan
    J Immunol 166:6578-84. 2001
    ..Moreover, NKT cells mediate alpha-GalCer-induced hepatocyte injury through Fas-Fas ligand signaling...
  43. pmc Intralymphatic immunization enhances DNA vaccination
    K J Maloy
    Department of Dermatology, and Institute of Experimental Immunology, Universitatsspital Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 98:3299-303. 2001
    ..Because injection directly into a lymph node is a rapid and easy procedure in humans, these results have important clinical implications for DNA vaccination...
  44. ncbi Dendritic cells injected via different routes induce immunity in cancer patients
    L Fong
    Department of Pathology, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    J Immunol 166:4254-9. 2001
    ..d. and two of six for i.l. routes. These results suggest that while activated DC can prime T cell immunity regardless of route, the quality of this response and induction of Ag-specific Abs may be affected by the route of administration...
  45. ncbi Transport of viral-size particulate matter after intravenous versus intralymphatic entry
    A A Fokin
    Department of Thoracic and Cardiovascular Surgery, Heineman Medical Research Laboratory, Carolinas Medical Center, Charlotte, NC 28203, USA
    Microcirculation 7:357-65. 2000
    ..Investigation of the transport of viral-size particles after intravenous versus intralymphatic injection and the functional validity of lymphatico-venous communications...
  46. ncbi A profound deficiency in thymic progenitor cells in mice lacking Jak3
    A M Baird
    Department of Pathology, University of Massachusetts Medical School, Worcester 01655, USA
    J Immunol 165:3680-8. 2000
    ..These data clearly demonstrate a strong common basis for the T cell deficiencies in mice and humans lacking gammac/Jak3 signaling pathways...
  47. ncbi Ionic and potential changes of the endolymphatic sac induced by endolymph volume changes
    A N Salt
    Department of Otolaryngology, Box 8115, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Hear Res 149:46-54. 2000
    ..If the ES plays a part in the restoration of normal endolymph volume, this process appears to proceed slowly, based on the prolonged time courses of ionic changes observed...
  48. ncbi An intra-Peyer's patch gene transfer model for studying mucosal tolerance: distinct roles of B7 and IL-12 in mucosal T cell tolerance
    Y Chen
    Department of Molecular and Cellular Engineering, Institute for Human Gene Therapy, and Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 165:3145-53. 2000
    ..Based on these findings, we propose a new model to explain the paradoxical roles of B7 in mucosal immunity and tolerance...
  49. ncbi Local application of capsaicin into the draining lymph nodes attenuates expression of adjuvant-induced arthritis
    D Lorton
    Hoover Arthritis Center, Sun Health Research Institute, Sun City, Arizona 85372, USA
    Neuroimmunomodulation 7:115-25. 2000
    ..These findings support a role for small, nonmyelinated, sensory nerves that modulate immune responses in DLN in the development and progression of AA in Lewis rats...
  50. ncbi Analysis of signals and functions of the chimeric human granulocyte-macrophage colony-stimulating factor receptor in BA/F3 cells and transgenic mice
    S Watanabe
    Department of Molecular Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Immunol 164:3635-44. 2000
    ..Thus, it appears that the cytoplasmic region of the alpha subunit is not required for hGM-CSF promoting activities, even in bone marrow cells...
  51. ncbi Trimetazidine prevents cochlear lesions induced by intraperitoneal and perilymphatic administration of kainic acid
    P Gil-Loyzaga
    Department of Surgery II ORL, Faculty of Medicine and Center of Cell Culture CAI UCM, Complutense University of Madrid, Apartado de Correos 60075, 28080, Madrid, Spain
    Brain Res 826:95-103. 1999
    ..Our results are in agreement with recent clinical studies and suggest that TMZ could be an active drug on cochlear impairment linked to hypoxic-ischaemic syndromes...
  52. ncbi Intranodal injection of anticancer drugs into fixed cervical metastatic lymph nodes
    T Osaki
    Department of Oral Surgery, Kochi Medical School, Japan
    Oral Dis 3:247-53. 1997
    ..In patients with head and neck carcinoma, fixed enlarged metastatic lymph nodes (LNs) are sometimes inoperable and carry an increased risk of mortality. To control metastatic LNs, we attempted intranodal injection of anticancer agents...
  53. ncbi Drug depots in lymph nodes: which carrier is most appropriate?
    P Hirnle
    Department of Gynaecology, University of Tubingen
    J Microencapsul 8:103-19. 1991
    ..The large unilamellar liposomes produced with detergent dialysis technique were found to be most appropriate for this purpose since they fulfill all the above criteria...
  54. ncbi Immunotherapy of metastatic kidney cancer
    G Pizza
    Immunotherapy Module, Operative Unit of Urology, Department of Urology, S Orsola Malpighi Hospital, Via P Palagi 9, 40138 Bologna, Italy
    Int J Cancer 94:109-20. 2001
    From April 1986 to September 2000, 122 MRCC patients were treated by monthly intralymphatic injections (containing a mean of 573 IL-2 U and 26 x 10(6) LAK cells) and i.m...
  55. ncbi [Endolymphatic therapy]
    K Slusarczyk

    Pol Merkur Lekarski 11:530-1. 2001
    ..There are more and more attempts of using the cytostatics placed in liposomes in endolymphatic...
  56. ncbi Thymic myoid cells as a myasthenogenic antigen and antigen-presenting cells
    Megumi Y Matsumoto
    Division of Surgical Oncology, Department of Translational Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Neuroimmunol 150:80-7. 2004
    ..These results suggest that myoid cells have the potential antigenicity to induce anti-AChR and the functions of antigen-presenting cells, but their expansion in the thymus may not directly cause MG...
  57. ncbi Cutting edge: an endogenous pathway to systemic inflammatory response syndrome (SIRS)-like reactions through Toll-like receptor 4
    Geoffrey B Johnson
    Department of Immunology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    J Immunol 172:20-4. 2004
    ..These results provide a molecular explanation for the initiation of SIRS...
  58. ncbi [Lymphotropic therapy for acute purulent odontogenic jaw periostitis]
    I V Maiborodin
    Stomatologiia (Mosk) 82:27-31. 2003
    ..Microcirculation parameters and tissue leukocyte cytogram in gingival mucosal tissue adjacent to the canines and premolars differed negligibly in patients treated by different methods...
  59. ncbi Adenovirus-transduced dendritic cells injected into skin or lymph node prime potent simian immunodeficiency virus-specific T cell immunity in monkeys
    Kevin Brown
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Immunol 171:6875-82. 2003
    ..However, boost injections of adenovirus-transduced DC were generally limited in efficacy. These findings support the use of adenovirus-transduced DC in the therapy of HIV infection and cancer...
  60. ncbi Receptor mechanisms of prenodal lymphatic constriction by dopamine
    David E Dobbins
    Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814 4799, USA
    Regul Pept 114:7-13. 2003
    ..These lymph vessels do contain both DA(1)- and DA(2)-receptors but stimulation of these receptors results in lymphatic smooth muscle relaxation...
  61. ncbi Characterization of thymic progenitors in adult mouse bone marrow
    S Scott Perry
    Department of Pathology, University of Utah, 30 North 1900 East, Salt Lake City, UT 84132, USA
    J Immunol 170:1877-86. 2003
    ..Furthermore, they note disparity in B and T cell expansion from this lymphoid progenitor population and suggest that it contains the progenitor primarily responsible for seeding the thymus throughout life...
  62. ncbi Expression of IFN-gamma upon triggering of activating Ly49D NK receptors in vitro and in vivo: costimulation with IL-12 or IL-18 overrides inhibitory receptors
    John R Ortaldo
    Laboratory of Experimental Immunology, National Cancer Institute Center for Cancer Research, B 560, Room 31 93, Frederick, MD 21702 1201, USA gov
    J Immunol 170:1763-9. 2003
    ....
  63. ncbi Intranodal injection of semimature monocyte-derived dendritic cells induces T helper type 1 responses to protein neoantigen
    Michel Gilliet
    Department of Dermatology, University of Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland
    Blood 102:36-42. 2003
    ..Our results indicate that intranodal vaccination with semimature DCs can prime strong, long-lasting CD4 T-cell responses with a TH1-type cytokine profile in cancer patients...
  64. ncbi A review of technical aspects of sentinel lymph node identification for breast cancer
    Todd M Tuttle
    Department of Surgery, University of Minnesota, Minneapolis 55455, USA
    J Am Coll Surg 195:261-8. 2002
  65. ncbi [Lymphotropic antibacterial therapy for preventing inflammatory complications of mandibular fractures]
    N V Iaremenko
    Stomatologiia (Mosk) 81:20-3. 2002
    ..Basing upon clinical experience we worked out indications to the regional lymphotropic antibacterial therapy as a part of complex prophylaxis of posttraumatic mandible osteomyelitis...
  66. ncbi Stromal cells provide the matrix for migration of early lymphoid progenitors through the thymic cortex
    Susan E Prockop
    Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    J Immunol 169:4354-61. 2002
    ....
  67. ncbi CD25+ immunoregulatory CD4 T cells mediate acquired central transplantation tolerance
    Jose Trani
    Harrison Department of Surgical Research, Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 170:279-86. 2003
    ..Our results suggest that both clonal frequency reduction in the thymus and immunoregulatory T cells exported from the thymus are critical to transplantation tolerance induced by intrathymic Ag inoculation...
  68. ncbi Lymphatic mapping with tracer administration into the primary breast cancer
    O E Nieweg
    Department of Surgery, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Eur J Surg Oncol 29:95-7. 2003
    ..The intralesional injection technique avoids potential injection of tracer fluid across a lymphatic watershed, it enables identification of extra-axillary sentinel nodes and allows probe-guided excision of non-palpable tumours...
  69. ncbi A new intra-NALT route elicits mucosal and systemic immunity against Moraxella catarrhalis in a mouse challenge model
    Yingchun Hou
    National Institute for Deafness and Other Communication Disorders, National Institute of Health, Rockville, MD 20850, USA
    Vaccine 20:2375-81. 2002
    ..This new route can be used as a model to study mucosal antigens or vaccine candidates for antigen activation and interaction with the NALT that is one of major inductive sites for common mucosal immune system...
  70. ncbi NOD/SCID mice engrafted with human peripheral blood lymphocytes can be a model for investigating B cells responding to blood group A carbohydrate determinant
    Wendy Zhou
    Department of Surgery, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Transpl Immunol 12:9-18. 2003
    ..The human PBMC-NOD/SCID chimera developed by injection of blood group O human PBMC might be a useful in vivo model to test effects of immunosuppressants or other approaches on human B cells that respond to blood group A antigens...
  71. ncbi Migration of dendritic cell based cancer vaccines: in vivo veritas?
    Gosse J Adema
    Department of Tumor Immunology, Nijmegen Center for Molecular Life Sciences, and Medical Oncology, Nijmegen, The Netherlands
    Curr Opin Immunol 17:170-4. 2005
    ..Recent advances have been made in understanding DC migration in the context of DC-based vaccines...
  72. ncbi Streptomycin perfusion of the labyrinth
    J J Shea
    Shea Clinic, Shea Clinic Foundation, Memphis, Tennessee
    Acta Otolaryngol Suppl 485:123-30. 1991
    ..and Norris & Shea and two guinea pig experiments with gentamicin by Kimura.(ABSTRACT TRUNCATED AT 250 WORDS)..

Research Grants9

  1. FAS LIGAND GENE TRANSFER IN ARTHRITIS
    Youhai Chen; Fiscal Year: 2001
    ..Information generated from these studies may help elucidate the mechanisms by which FasL gene transfer diminishes autoimmune arthritis and may lead to the development of a novel strategy for treatment of autoimmune arthritis. ..
  2. COSTIMULATION IN MUCOSAL IMMUNITY AND TOLERANCE
    Youhai Chen; Fiscal Year: 2002
    ..The CTLA4 deficient ovalbumin-specific T-cells will then be adoptively transferred into normal mice and their reactivity to mucosal antigens examined. ..
  3. AUTOIMMUNE ENCEPHALOMYELITIS AND NF-KB
    Youhai Chen; Fiscal Year: 2003
    ..Novel strategies targeting NF-kappaB may then be developed to treat or prevent autoimmune diseases. ..
  4. IL-6 IN AUTOIMMUNE ENCEPHALOMYELITIS
    Youhai Chen; Fiscal Year: 2003
    ..Information generated from these studies may not only help elucidate the mechanisms of IL-6 action in EAE but also aid in developing novel strategies to treat autoimmune diseases such as multiple sclerosis. ..
  5. Discovery and functional assessment of the rat op gene
    DAVID DOBBINS; Fiscal Year: 2004
    ..abstract_text> ..
  6. Autoimmune Encephalomyelitis and p53
    Youhai Chen; Fiscal Year: 2006
    ..Novel strategies targeting p53 may then be developed to treat or prevent autoimmune diseases. ..
  7. Autoimmune Encephalomyelitis and TRAIL
    Youhai Chen; Fiscal Year: 2007
    ..abstract_text> ..
  8. Type I diabetes and TRAIL
    Youhai Chen; Fiscal Year: 2007
    ..Information generated from these studies may not only help elucidate the mechanisms of TRAIL action in type I diabetes but also aid in developing a novel strategy to treat the disease. ..
  9. Autoimmune encephalomyelitis and Bcl-2- interacting mediator
    Youhai H Chen; Fiscal Year: 2010
    ....