injections

Summary

Top Publications

  1. ncbi Closed-chest cell injections into mouse myocardium guided by high-resolution echocardiography
    Matthew L Springer
    Division of Cardiology, Department of Medicine, University of California, San Francisco, California 94143 0124, USA
    Am J Physiol Heart Circ Physiol 289:H1307-14. 2005
  2. ncbi Effect of gene therapy on visual function in Leber's congenital amaurosis
    James W B Bainbridge
    Institute of Ophthalmology, University College London, London, United Kingdom
    N Engl J Med 358:2231-9. 2008
  3. ncbi Autologous growth factor injections in chronic tendinopathy: a systematic review
    R J de Vos
    Department of Sports Medicine, The Hague Medical Centre Antoniushove, Leidschendam, The Netherlands
    Br Med Bull 95:63-77. 2010
  4. ncbi A phase II randomized double-masked trial of pegaptanib, an anti-vascular endothelial growth factor aptamer, for diabetic macular edema
    Emmett T Cunningham
    Stanford University, USA
    Ophthalmology 112:1747-57. 2005
  5. pmc Multiple injections of electroporated autologous T cells expressing a chimeric antigen receptor mediate regression of human disseminated tumor
    Yangbing Zhao
    Abramson Family Cancer Research Institute and Department of Pathology and Laboratory Medicine and Thoracic Oncology Research Laboratory and Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6160, USA
    Cancer Res 70:9053-61. 2010
  6. ncbi Tracer-cocktail injections for combined pre- and intraoperative multimodal imaging of lymph nodes in a spontaneous mouse prostate tumor model
    Anne C van Leeuwen
    Antoni van Leeuwenhoek Hospital, Division of Diagnostic Oncology, 1066 CX Amsterdam, The NetherlandsAntoni van Leeuwenhoek Hospital, Division of Immunology, 1066 CX Amsterdam, The NetherlandsAntoni van Leeuwenhoek Hospital, Netherlands Cancer Institute, Division of Surgical Oncology, 1066 CX Amsterdam, The Netherlands
    J Biomed Opt 16:016004. 2011
  7. ncbi Psychiatrists' use, knowledge and attitudes to first- and second-generation antipsychotic long-acting injections: comparisons over 5 years
    M X Patel
    Division of Psychological Medicine, Institute of Psychiatry, King s College London, London, UK
    J Psychopharmacol 24:1473-82. 2010
  8. ncbi Effects of subretinal injections of indocyanine green, trypan blue, and glucose in rabbit eyes
    Fernando M Penha
    Department of Ophthalmology Vision Institute, Federal University of Sao Paulo, Sao Paulo, Brazil
    Ophthalmology 114:899-908. 2007
  9. ncbi A comparison of two intraosseous anesthetic techniques in mandibular posterior teeth
    Juliane Gallatin
    The Ohio State University, College of Dentistry, Columbus 43218, USA
    J Am Dent Assoc 134:1476-84. 2003
  10. pmc Intermittent recombinant TSH injections prevent ovariectomy-induced bone loss
    Li Sun
    The Mount Sinai Bone Program and The Thyroid Research Unit at the Bronx Veterans Affairs Medical Center, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 105:4289-94. 2008

Detail Information

Publications352 found, 100 shown here

  1. ncbi Closed-chest cell injections into mouse myocardium guided by high-resolution echocardiography
    Matthew L Springer
    Division of Cardiology, Department of Medicine, University of California, San Francisco, California 94143 0124, USA
    Am J Physiol Heart Circ Physiol 289:H1307-14. 2005
    ..However, its small heart size hampers accurate implantation into the left ventricular (LV) wall. Precise injections have required surgical visualization of the heart, which is subject to complications and is impractical for ..
  2. ncbi Effect of gene therapy on visual function in Leber's congenital amaurosis
    James W B Bainbridge
    Institute of Ophthalmology, University College London, London, United Kingdom
    N Engl J Med 358:2231-9. 2008
    ..We administered to three young adult patients subretinal injections of recombinant adeno-associated virus vector 2/2 expressing RPE65 complementary DNA (cDNA) under the control of ..
  3. ncbi Autologous growth factor injections in chronic tendinopathy: a systematic review
    R J de Vos
    Department of Sports Medicine, The Hague Medical Centre Antoniushove, Leidschendam, The Netherlands
    Br Med Bull 95:63-77. 2010
    ..There are many proposed treatment options for chronic tendinopathy. Treatments in the form of injections with autologous whole blood or PRP are increasingly used in clinical practice...
  4. ncbi A phase II randomized double-masked trial of pegaptanib, an anti-vascular endothelial growth factor aptamer, for diabetic macular edema
    Emmett T Cunningham
    Stanford University, USA
    Ophthalmology 112:1747-57. 2005
    ..To evaluate the safety and efficacy of pegaptanib sodium injection (pegaptanib) in the treatment of diabetic macular edema (DME)...
  5. pmc Multiple injections of electroporated autologous T cells expressing a chimeric antigen receptor mediate regression of human disseminated tumor
    Yangbing Zhao
    Abramson Family Cancer Research Institute and Department of Pathology and Laboratory Medicine and Thoracic Oncology Research Laboratory and Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6160, USA
    Cancer Res 70:9053-61. 2010
    ..Multiple injections of RNA CAR-electroporated T cells mediated regression of large vascularized flank mesothelioma tumors in NOD/..
  6. ncbi Tracer-cocktail injections for combined pre- and intraoperative multimodal imaging of lymph nodes in a spontaneous mouse prostate tumor model
    Anne C van Leeuwen
    Antoni van Leeuwenhoek Hospital, Division of Diagnostic Oncology, 1066 CX Amsterdam, The NetherlandsAntoni van Leeuwenhoek Hospital, Division of Immunology, 1066 CX Amsterdam, The NetherlandsAntoni van Leeuwenhoek Hospital, Netherlands Cancer Institute, Division of Surgical Oncology, 1066 CX Amsterdam, The Netherlands
    J Biomed Opt 16:016004. 2011
    ..Furthermore, this approach improves fluorescent-based guidance and enables both accurate surgical planning and intraoperative detection, based on a single injection...
  7. ncbi Psychiatrists' use, knowledge and attitudes to first- and second-generation antipsychotic long-acting injections: comparisons over 5 years
    M X Patel
    Division of Psychological Medicine, Institute of Psychiatry, King s College London, London, UK
    J Psychopharmacol 24:1473-82. 2010
    Psychiatrists' attitudes and knowledge about antipsychotic long-acting injections (LAIs) are important given the increasing emphasis on patient choice in treatment and the availability of second-generation antipsychotic (SGA) LAIs...
  8. ncbi Effects of subretinal injections of indocyanine green, trypan blue, and glucose in rabbit eyes
    Fernando M Penha
    Department of Ophthalmology Vision Institute, Federal University of Sao Paulo, Sao Paulo, Brazil
    Ophthalmology 114:899-908. 2007
    To evaluate the effects of subretinal injections of indocyanine green (ICG), trypan blue, glucose (GL), and balanced salt solution (BSS) in rabbits.
  9. ncbi A comparison of two intraosseous anesthetic techniques in mandibular posterior teeth
    Juliane Gallatin
    The Ohio State University, College of Dentistry, Columbus 43218, USA
    J Am Dent Assoc 134:1476-84. 2003
    ..The authors undertook a study to compare the two systems' anesthetic outcomes in primary intraosseous injections in mandibular posterior teeth.
  10. pmc Intermittent recombinant TSH injections prevent ovariectomy-induced bone loss
    Li Sun
    The Mount Sinai Bone Program and The Thyroid Research Unit at the Bronx Veterans Affairs Medical Center, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 105:4289-94. 2008
    ..In contrast, loss of function of a mutant TSHR (Pro --> Leu at 556) in congenital hypothyroid mice activates osteoclast differentiation, confirming once again our premise that TSHRs have a critical role in regulating bone remodeling...
  11. pmc Dose-dependent effects of multiple acute cocaine injections on maternal behavior and aggression in Sprague-Dawley rats
    J M Johns
    Department of Psychiatry, University of North Carolina, Chapel Hill, N C 27599 7096, USA
    Dev Neurosci 20:525-32. 1998
    ..5 mg/kg of cocaine hydrochloride HCl, or normal saline. Injections were given immediately postpartum following delivery of their final pup (PPD 1), and again on postpartum day 3 (..
  12. pmc Use of injections in healthcare settings worldwide, 2000: literature review and regional estimates
    Yvan J F Hutin
    Department of Blood Safety and Clinical Technology, World Health Organization, Avenue Appia, 20, CH 1211 Geneva, Switzerland
    BMJ 327:1075. 2003
    ..To describe injection practices worldwide in terms of frequency and safety...
  13. ncbi Efficacy and safety of corticosteroid injections and other injections for management of tendinopathy: a systematic review of randomised controlled trials
    Brooke K Coombes
    Division of Physiotherapy, School of Health and Rehabilitation Sciences, University of Queensland, St Lucia, Queensland, Australia
    Lancet 376:1751-67. 2010
    ..Few evidence-based treatment guidelines for tendinopathy exist. We undertook a systematic review of randomised trials to establish clinical efficacy and risk of adverse events for treatment by injection...
  14. ncbi Intravitreal injection of crystalline cortisone as adjunctive treatment of proliferative diabetic retinopathy
    J B Jonas
    Department of Ophthalmology and Eye Hospital, Faculty of Clinical Medicine, Mannheim of the Ruprecht Karls University, Heidelberg, Germany
    Am J Ophthalmol 131:468-71. 2001
    To report the clinical outcome and complications of intravitreal injections of crystalline cortisone in patients undergoing pars plana vitrectomy for treatment of proliferative diabetic retinopathy.
  15. ncbi Intraocular pressure elevation after intravitreal triamcinolone acetonide injection
    Jost B Jonas
    Department of Ophthalmology, Faculty of Clinical Medicine Mannheim of the University Heidelberg, Heidelberg, Germany
    Ophthalmology 112:593-8. 2005
    To report on intraocular pressure (IOP) after intravitreal injections of triamcinolone acetonide.
  16. ncbi Oral, injected and implanted contraceptives and breast cancer risk among U.S. Hispanic and non-Hispanic white women
    Carol Sweeney
    Division of Epidemiology, University of Utah School of Medicine, Salt Lake City, UT, USA
    Int J Cancer 121:2517-23. 2007
    ..17) for both ethnic groups combined, and 2.23 (95% CI 1.17, 4.25) for ER negative tumors. Hormonal contraceptive injections were used by 3.3% of Hispanic controls and 2.8% of non-Hispanic white controls, OR 1.23 (95% CI 0.88, 1.73)...
  17. ncbi Intracoronary injection of mononuclear bone marrow cells in acute myocardial infarction
    Ketil Lunde
    Department of Cardiology, Rikshospitalet University Hospital, Oslo, Norway
    N Engl J Med 355:1199-209. 2006
    ..We designed a randomized, controlled trial to further investigate the effects of this treatment...
  18. ncbi A novel injectable temperature-sensitive zinc doped chitosan/β-glycerophosphate hydrogel for bone tissue engineering
    Ramesh Niranjan
    Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur 603 203, Tamilnadu, India
    Int J Biol Macromol 54:24-9. 2013
    ..Thus, we suggest that the Zn-CS/β-GP hydrogel could have potential impact as an injectable in situ forming scaffold for bone tissue engineering applications...
  19. ncbi Injectable and biodegradable thermosensitive hydrogels loaded with PHBHHx nanoparticles for the sustained and controlled release of insulin
    Q Peng
    Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041, People s Republic of China
    Acta Biomater 9:5063-9. 2013
    ..biodegradable and thermosensitive NP-CS/GP gels have great potential for use in novel ultralong-acting insulin injections. In addition, the NP-loaded hydrogel system also paves the way for long-term delivery of other proteins and ..
  20. pmc Long-term result of endoscopic Histoacryl (N-butyl-2-cyanoacrylate) injection for treatment of gastric varices
    Eun Jung Kang
    Institute for Digestive Research, Department of Internal Medicine, Soonchunhyang University College of Medicine, Seoul Hospital, Seoul 140 743, South Korea
    World J Gastroenterol 17:1494-500. 2011
    ..To evaluate the long-term efficacy and safety of endoscopic obliteration with Histoacryl(®) for treatment of gastric variceal bleeding and prophylaxis...
  21. ncbi Clinical guideline recommendations for antipsychotic long-acting injections
    John M Kane
    Department of Psychiatry, Zucker Hillside Hospital, 75 59 263 Street, Glen Oaks, NY 11004, USA
    Br J Psychiatry Suppl 52:S63-7. 2009
    Long-acting injections (LAIs) of antipsychotic drugs were developed over 40 years ago in an attempt to improve the long-term treatment of schizophrenia.
  22. ncbi Blindness following cosmetic injections of the face
    Davide Lazzeri
    Plastic and Reconstructive Surgery Unit, Hospital of Pisa Via Paradisa 2 Cisanello, 56100 Pisa, Italy
    Plast Reconstr Surg 129:995-1012. 2012
    Complications following facial cosmetic injections have recently heightened awareness of the possibility of iatrogenic blindness...
  23. ncbi Evaluation of safety for bilateral same-day intravitreal injections of antivascular endothelial growth factor therapy
    Luiz H Lima
    Vitreous, Retina, and Macula Consultants of New York, New York, New York 10022, USA
    Retina 29:1213-7. 2009
    To explore the incidence of complications after bilateral same-day intravitreal injections of antivascular endothelial growth factor pharmacotherapies in this retrospective interventional case series.
  24. pmc Provision of injectable contraceptives in Ethiopia through community-based reproductive health agents
    Ndola Prata
    University of California at Berkeley, School of Public Health, 229 University Hall, Berkeley, CA 94720 6390, United States of America
    Bull World Health Organ 89:556-64. 2011
    ..To determine whether community-based health workers in a rural region of Ethiopia can provide injectable contraceptives to women with similar levels of safety, effectiveness and acceptability as health extension workers (HEWs)...
  25. pmc Inflammation induced by infection potentiates tau pathological features in transgenic mice
    Michael Sy
    Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA
    Am J Pathol 178:2811-22. 2011
    ..Taken together, infectious agents that trigger central nervous system inflammation may serve as a comorbidity for AD, leading to cognitive impairments by a mechanism that involves exacerbation of tau pathological characteristics...
  26. ncbi Percutaneous intramyocardial stem cell injection in patients with acute myocardial infarction: first-in-man study
    K Krause
    Department of Cardiology, Asklepios Hospital St Georg, Hamburg, Germany
    Heart 95:1145-52. 2009
    ..However, preclinical studies have shown that intramyocardial cell injection is better than the intracoronary approach...
  27. pmc Ultrasound-guided in utero injections allow studies of the development and function of the eye
    Claudio Punzo
    Harvard Medical School, Department of Genetics, Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
    Dev Dyn 237:1034-42. 2008
    Ultrasound-guided in utero injections into the brain of murine embryos has been shown to facilitate gene delivery. We investigated whether these methods would allow gene transfer into ocular structures...
  28. ncbi Comparison of intravitreal versus posterior sub-Tenon's capsule injection of triamcinolone acetonide for diffuse diabetic macular edema
    Jose A Cardillo
    Hospital de Olhos de Araraquara, Araraquara, Sao Paulo, Brazil
    Ophthalmology 112:1557-63. 2005
    ..To compare the safety and efficacy of intravitreal versus posterior Sub-Tenon's capsule injection of triamcinolone acetonide for diffuse diabetic macular edema...
  29. ncbi Adeno-associated virus type 4 (AAV4) targets ependyma and astrocytes in the subventricular zone and RMS
    G Liu
    Program in Gene Therapy, University of Iowa, Iowa City, IA 52242, USA
    Gene Ther 12:1503-8. 2005
    ..In addition, SVZ injections were conducted on adult mice...
  30. pmc Disruption of vitellogenin gene function in adult honeybees by intra-abdominal injection of double-stranded RNA
    Gro V Amdam
    Centre for Integrative Genetics and Department of Animal Science, Agricultural University of Norway, N 1432 Aas, Norway
    BMC Biotechnol 3:1. 2003
    ..Here we assess two methods for probing gene function by RNA interference (RNAi) in adult honeybees...
  31. ncbi Vitreous concentrations of triamcinolone acetonide in human eyes after intravitreal or subtenon injection
    Makoto Inoue
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Am J Ophthalmol 138:1046-8. 2004
    To compare vitreous concentrations of triamcinolone acetonide (TA) achieved by prior therapeutic intravitreal and subtenon injections.
  32. ncbi Hepatitis A vaccine administration: comparison between jet-injector and needle injection
    J Williams
    Alaska Native Medical Center, Viral Hepatitis Program, 4315 Diplomacy Drive, Anchorage, AK 99508, USA
    Vaccine 18:1939-43. 2000
    ..To determine if a significant difference between these two methods in seroconversion rates or geometric mean titers of anti HAV antibody occurs at day 15, 30, and 210 days after vaccination...
  33. ncbi Acute intraocular inflammation after intravitreous injections of bevacizumab for treatment of neovascular age-related macular degeneration
    Sanjeewa S Wickremasinghe
    Medical Retina Unit, Royal Victorian Eye and Ear Hospital, Melbourne, Australia
    Ophthalmology 115:1911-5. 2008
    ..We describe acute intraocular inflammation after intravitreous injection of bevacizumab for the treatment of neovascular AMD...
  34. pmc Anthropological perspectives on injections: a review
    A V Reeler
    Health Access International, Royston, Herts, England
    Bull World Health Organ 78:135-43. 2000
    Qualitative studies from developing countries have pointed to the widespread popularity of injections. In addition to their use by formal and informal providers and traditional healers, there is now increasing evidence of the use of ..
  35. ncbi Efficacy of intraosseous injections of anesthetic in children and adolescents
    Jean Louis Sixou
    Department of Pediatric Dentistry, UFR d Odontologie de l Université de Rennes 1 and CHU de Rennes, France
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106:173-8. 2008
    The goal of this study was to determine the efficacy of the intraosseous (IO) injections of anesthetic as a primary technique in children and adolescents.
  36. ncbi Effect of donepezil and lercanidipine on memory impairment induced by intracerebroventricular streptozotocin in rats
    Swapnil Sonkusare
    Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, S A S Nagar 160062, Punjab, India
    Life Sci 77:1-14. 2005
    ..3 mg/kg) showed significant improvement in memory. When administered together, the effect of combination of these two drugs on memory and cholinesterase activity was higher than that obtained with either of the drugs when used alone...
  37. ncbi The efficacy of supplemental intraosseous anesthesia after insufficient mandibular block
    Samir Prohić
    Department of Oral Surgery and Oral Medicine, School of Dental Medicine, Bolnicka 4a, 71000 Sarajevo, Bosnia and Herzegovina
    Bosn J Basic Med Sci 5:57-60. 2005
    ..9% of mandibular molars. The difference between anesthetic efficacy of the classical mandibular block and anesthetic efficacy of the supplemental intraosseous anesthesia, applied after the insufficient mandibular block, is obvious...
  38. ncbi Ultrasound-guided versus 'blind' intraparotid injections of botulinum toxin-A for the treatment of sialorrhoea in patients with Parkinson's disease
    Okan Dogu
    Department of Neurology, Faculty of Medicine, Tip Fakultesi Hastanesi, Noroloji Anabilim Dali, Zeytinlibahce Cad, Mersin Universitesi, 33070 Mersin, Turkey
    Clin Neurol Neurosurg 106:93-6. 2004
    To investigate the efficacy and safety of intraparotid botulinum toxin-A (BTX-A) injections into parotid gland using ultrasound-guided versus nonguided techniques for the treatment of sialorrhoea in patients with Parkinson's disease (PD).
  39. ncbi Anesthetic efficacy of a repeated intraosseous injection following a primary intraosseous injection
    Joanne Jensen
    Private Practice, Pleasant Hill, CA, USA
    J Endod 34:126-30. 2008
    ..In conclusion, using the methodology presented, repeating the intraosseous injection 30 minutes after an initial intraosseous injection will provide an additional 15 minutes of pulpal anesthesia...
  40. ncbi The efficacy and safety of 0.75% levobupivacaine vs 0.75% bupivacaine for peribulbar anaesthesia
    D J Birt
    Department of Anaesthesia, Derriforf Hospital, Plymouth, UK
    Eye (Lond) 17:200-6. 2003
    ..Thus, this prospective, randomised, double-masked study was undertaken to assess the efficacy and safety of 0.75% levobupivacaine vs 0.75% bupivacaine, each with hyaluronidase, for peribulbar anaesthesia...
  41. ncbi Local injections of the 5-hydroxytryptamine antagonist mianserin into substantia nigra pars reticulata block tremulous jaw movements in rats: studies with a putative model of Parkinsonian tremor
    Brian B Carlson
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Psychopharmacology (Berl) 165:229-37. 2003
    ..Cholinomimetic-induced jaw movements are a putative model of parkinsonian tremor, and the ability of antipsychotic drugs to suppress these movements in rats is correlated with motor side-effect liability in humans...
  42. pmc Safety and efficacy of gene transfer for Leber's congenital amaurosis
    Albert M Maguire
    Scheie Eye Institute, University of Pennsylvania, USA
    N Engl J Med 358:2240-8. 2008
    ..Although the follow-up was very short and normal vision was not achieved, this study provides the basis for further gene therapy studies in patients with LCA...
  43. ncbi Bevacizumab-augmented retinal laser photocoagulation in proliferative diabetic retinopathy: a randomized double-masked clinical trial
    A Mirshahi
    Eye Research Center, Farabi Eye Hospital, Medical Sciences University of Tehran, Tehran, Iran
    Eur J Ophthalmol 18:263-9. 2008
    ..To evaluate the additional therapeutic effect of single intravitreal bevacizumab injection on standard laser treatment in the management of proliferative diabetic retinopathy...
  44. ncbi Complications of intravitreal injections
    Kapil M Sampat
    Philadelphia College of Osteopathic Medicine, Department of Ophthalmology, Philadelphia, Pennsylvania, USA
    Curr Opin Ophthalmol 21:178-83. 2010
    ..The purpose of this review is to highlight the complications associated with these injections.
  45. ncbi A mouse model of depression induced by repeated corticosterone injections
    Yunan Zhao
    Laboratory of Pharmaceutical Sciences, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China
    Eur J Pharmacol 581:113-20. 2008
    ..Mice received repeated injections of vehicle and 20 mg/kg of corticosterone for 1, 3 and 5 weeks, and then were subjected to the forced-swim and ..
  46. ncbi Triamcinolone acetonide as an adjuvant in the surgical treatment of retinal detachment with proliferative vitreoretinopathy
    Rizwan A Cheema
    Cardiff Eye Unit, University Hospital of Wales, Cardiff, United Kingdom
    Ophthalmic Surg Lasers Imaging 38:365-70. 2007
    ..To report the efficacy of intravitreal triamcinolone acetonide as an adjuvant in the surgical management of cases with advanced proliferative vitreoretinopathy (PVR)...
  47. ncbi Year 2 efficacy results of 2 randomized controlled clinical trials of pegaptanib for neovascular age-related macular degeneration
    U Chakravarthy
    Centre for Vision Sciences, The Queen s University of Belfast and The Royal Victoria Hospital, Belfast, United Kingdom
    Ophthalmology 113:1508.e1-25. 2006
    ..To evaluate the efficacy of a second year of pegaptanib sodium therapy in patients with neovascular age-related macular degeneration (AMD)...
  48. ncbi Selective nerve root blocks for the treatment of sciatica: evaluation of injection site and effectiveness--a study with patients and cadavers
    C W Pfirrmann
    Department of Radiology, University Hospital Balgrist, Forchstrasse 340, Ch 8008 Zurich, Switzerland
    Radiology 221:704-11. 2001
    ..To relate different types of radiographic contrast material distributions to anatomic compartments by using cadaveric specimens and to relate the injection site to treatment-induced discomfort and therapeutic effect...
  49. ncbi ESCRS study of prophylaxis of postoperative endophthalmitis after cataract surgery: Preliminary report of principal results from a European multicenter study
    Peter Barry
    European Society of Cataract and Refractive Surgeons, Dublin, Ireland
    J Cataract Refract Surg 32:407-10. 2006
    ..To report results in the European Society of Cataract & Refractive Surgeons (ESCRS) multicenter study of the prophylaxis of endophthalmitis after cataract surgery...
  50. ncbi Autologous blood injections for refractory lateral epicondylitis
    Scott G Edwards
    Department of Orthopaedic Surgery, University of Tennessee, Memphis Campbell Clinic, USA
    J Hand Surg Am 28:272-8. 2003
    ..The purpose of this study was to evaluate prospectively the results of refractory lateral epicondylitis treated with autologous blood injections.
  51. pmc Measles virus spread and pathogenesis in genetically modified mice
    B Mrkic
    Institut für Molekularbiologie Abt I, Universitat Zurich, Zurich, Switzerland
    J Virol 72:7420-7. 1998
    ..We conclude that in mice alpha/beta interferon controls MV infection and that a high-affinity receptor facilitates, but is not strictly required for, MV spread and pathogenesis...
  52. ncbi Risk factors for hepatitis C virus infection in male adults in Rawalpindi-Islamabad, Pakistan
    A Bari
    Division of Epidemiology and Biostatistics, Department of Community Health Sciences, The Aga Khan University, Karachi, Pakistan
    Trop Med Int Health 6:732-8. 2001
    ..To identify risk factors associated with HCV infection in Islamabad-Rawalpindi...
  53. ncbi Fear of injections in young adults: prevalence and associations
    Yael Nir
    Infectious Diseases and Travel Clinic, Bnai Zion Medical Center, Haifa, Israel
    Am J Trop Med Hyg 68:341-4. 2003
    Fear of injections may interfere with receipt of vaccines. The frequency, associations, and precipitators of fear-provoking factors of 400 travelers visiting a travel health clinic were evaluated...
  54. ncbi Intravitreal bevacizumab (Avastin) in the treatment of macular edema secondary to branch retinal vein occlusion
    Melvin D Rabena
    California Retina Consultants and Research Foundation, Santa Barbara, CA 93103, USA
    Retina 27:419-25. 2007
    ..To report the authors' experience after intravitreal bevacizumab (Avastin, Genentech) injection in patients with macular edema (ME) secondary to branch retinal vein occlusive disease (BRVO)...
  55. ncbi Twelve-month safety of intravitreal injections of bevacizumab (Avastin): results of the Pan-American Collaborative Retina Study Group (PACORES)
    Lihteh Wu
    Instituto de Cirugia Ocular, San Jose, Costa Rica
    Graefes Arch Clin Exp Ophthalmol 246:81-7. 2008
    ..Bevacizumab, a humanized recombinant monoclonal IgG antibody that binds and inhibits all VEGF isoforms, has been proposed as an alternative treatment option...
  56. ncbi Catheter-based autologous bone marrow myocardial injection in no-option patients with advanced coronary artery disease: a feasibility study
    Shmuel Fuchs
    Cardiovascular Research Institute, MedStar Research Institute, Washington Hospital Center, 110 Irving Street NW, 4B 1, Washington, DC 20010, USA
    J Am Coll Cardiol 41:1721-4. 2003
    ..We conducted a pilot study to evaluate the feasibility of transendocardial delivery of autologous bone marrow (ABM) strategy in patients with severe symptomatic chronic myocardial ischemia not amenable to conventional revascularization...
  57. pmc Pneumatic displacement and intravitreal bevacizumab: a new approach for management of submacular hemorrhage in choroidal neovascular membrane
    Shobhit Chawla
    Vitreo Retinal Services, Lucknow, India
    Indian J Ophthalmol 57:155-7. 2009
    ..05 ml, along with 0.5 ml of SF6 was injected through the pars plana into the vitreous cavity. Postoperative best corrected visual acuity improved in all eyes with complete or partial displacement of SMH out of the foveal area...
  58. ncbi Intravitreal triamcinolone for uveitic cystoid macular edema: an optical coherence tomography study
    R J Antcliff
    GKT Department of Ophthalmology, Rayne Institute, St Thomas' Hospital, Lambeth Palace Road, London SE1 7EH, England, UK
    Ophthalmology 108:765-72. 2001
    ..14-0.42). CONCLUSIONS: Complete anatomic and, to some extent, functional recovery can be induced by intravitreal TA despite long-term refractory inflammatory CME. Optical coherence tomography aids in the management of these cases...
  59. ncbi Fear of blood, injury, and injections, and its relationship to dental anxiety and probability of avoiding dental treatment among 18-year-olds in Norway
    Margrethe Vika
    Faculty of Psychology, University of Bergen, Norway
    Int J Paediatr Dent 18:163-9. 2008
    ..More knowledge about the relationship between blood-injury-injection phobia (BIIP) and dental anxiety (DA) may give new clinically relevant information in the assessment and management of children with DA...
  60. ncbi Targeted alpha-radionuclide therapy of functionally critically located gliomas with 213Bi-DOTA-[Thi8,Met(O2)11]-substance P: a pilot trial
    D Cordier
    Division of Neurosurgery, University Hospitals, Basel, Switzerland
    Eur J Nucl Med Mol Imaging 37:1335-44. 2010
    ..Therefore, we evaluated locally injected (213)Bi-DOTA-substance P in patients with critically located gliomas as the primary therapeutic modality...
  61. ncbi Thermosensitive chitosan-Pluronic hydrogel as an injectable cell delivery carrier for cartilage regeneration
    Kyung Min Park
    Department of Molecular Science and Technology, Ajou University, Suwon, Republic of Korea
    Acta Biomater 5:1956-65. 2009
    ..These results suggested that the CP hydrogel has potential as an injectable cell delivery carrier for cartilage regeneration and could serve as a new biomaterial for tissue engineering...
  62. ncbi Safety of repeat intravitreal injections of bevacizumab versus ranibizumab: our experience after 2,000 injections
    Ioannis D Ladas
    1st Department of Ophthalmology, Medical School of Athens University, Athens, Greece
    Retina 29:313-8. 2009
    To compare the safety of repeat intravitreal injections of bevacizumab versus ranibizumab performed on a large series of patients during the past 2 years period of time.
  63. ncbi Antipsychotic long-acting injections in clinical practice: medication management and patient choice
    Richard Gray
    Faculty of Health, University of East Anglia, Norwich NR4 7TJ, UK
    Br J Psychiatry Suppl 52:S51-6. 2009
    ..A patient-centred approach to care, focusing on recovery, demands a reconsideration of how choices are made about treatment, how this affects medication adherence, and the role of long-acting antipsychotics (LAIs) in this process...
  64. ncbi Evaluation of 19 cases of inadvertent globe perforation due to periocular injections
    Salil S Gadkari
    Gadkari Eye Centre, Pune, India
    Indian J Ophthalmol 55:103-7. 2007
    ..Inadvertent globe perforation due to periocular injection is a serious iatrogenic complication...
  65. ncbi Bilateral simultaneous intravitreal injections in the office setting
    Sophie J Bakri
    Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Ophthalmol 148:66-9.e1. 2009
    To report the outcomes and complications of bilateral simultaneous intravitreal injections performed in the office.
  66. pmc Efficacy and safety of multiple intravitreal triamcinolone injections for refractory diabetic macular oedema
    Mark C Gillies
    Save Sight and Eye Health Institute, Department of Clinical Ophthalmology, University of Sydney, GPO Box 4337, Sydney NSW 2001, Australia
    Br J Ophthalmol 91:1323-6. 2007
    The efficacy and safety of repeated injections of intravitreal triamcinolone (IVTA) for diabetic macular oedema is unclear, with results of previous reports conflicting.
  67. ncbi Reinforcing effects of central ethanol injections in newborn rat pups
    Michael E Nizhnikov
    Department of Psychology, Center for Developmental Psychobiology, Binghamton University SUNY, Binghamton, New York 13902, USA
    Alcohol Clin Exp Res 30:2089-96. 2006
    ..Given that early ethanol exposure can promote its future abuse, it is vital to discover the mechanisms behind reinforcing effects of ethanol at this stage of life...
  68. pmc Unsafe injections in the developing world and transmission of bloodborne pathogens: a review
    L Simonsen
    World Health Organization, Geneva, Switzerland
    Bull World Health Organ 77:789-800. 1999
    Unsafe injections are suspected to occur routinely in developing countries...
  69. ncbi Olanzapine long-acting injection: a review of its use in the treatment of schizophrenia
    James E Frampton
    Adis, a Wolters Kluwer Business, Auckland, New Zealand
    Drugs 70:2289-313. 2010
    ..1% of injections in clinical trials...
  70. pmc Macrophages inhibit neovascularization in a murine model of age-related macular degeneration
    Rajendra S Apte
    Department of Ophthalmology, Washington University School of Medicine, St Louis, Missouri, USA
    PLoS Med 3:e310. 2006
    ..The current theory is that macrophage infiltration promotes the development of neovascularization in CNV...
  71. ncbi Localization of the sentinel lymph node in tongue VX2 carcinoma via indirect CT lymphography combined with methylene blue dye injection
    Haitao Wu
    Department of Otolaryngology Head and Neck Surgery, EENT Hospital, Fudan University, 83 Fenyang Road, Shanghai, PR China
    Acta Otolaryngol 130:503-10. 2010
    ..Indirect computed tomography lymphography (CT-LG) combined with blue dye injection can locate the sentinel lymph node (SLN) in tongue carcinoma...
  72. ncbi Overprescribing in China, driven by financial incentives, results in very high use of antibiotics, injections, and corticosteroids
    Yongbin Li
    Huazhong University of Science and Technology, Wuhan, China
    Health Aff (Millwood) 31:1075-82. 2012
    ..These findings point to the need to integrate rational prescribing into China's ongoing health care reform...
  73. ncbi Circadian activity precedes daily methamphetamine injections in the rat
    A E Kosobud
    Department of Psychology, IN University, Bloomington 47405, USA
    Neurosci Lett 250:99-102. 1998
    Scheduled daily injections of methamphetamine (MA) produced locomotor activity that preceded and followed the usual time of injection in rats housed under conditions of constant, moderately dim light and temporally distributed feeding...
  74. ncbi Botulinum toxin A (Botox) intradetrusor injections in adults with neurogenic detrusor overactivity/neurogenic overactive bladder: a systematic literature review
    Gilles Karsenty
    Hopital Sainte Marguerite, Marseille, France
    Eur Urol 53:275-87. 2008
    ..systematic literature review discusses the efficacy and safety of botulinum toxin type A (Botox) intradetrusor injections in adults with neurogenic detrusor overactivity (NDO) and urinary incontinence or overactive bladder symptoms of ..
  75. ncbi Injectable calcium sulfate/mineralized collagen-based bone repair materials with regulable self-setting properties
    Zonggang Chen
    National Glycoengineering Research Center, Shandong University, Jinan, 250100, People s Republic of China
    J Biomed Mater Res A 99:554-63. 2011
    ..It can offer a satisfactory biological environment for growing new bone in the implants and for stimulating bone formation...
  76. ncbi Reducing use of injections through interactional group discussions: a randomized controlled trial
    R Bhunia
    Field Epidemiology Training Programme, National Institute of Epidemiology, Indian Council of Medical Research, Chennai, India
    Indian Pediatr 47:409-14. 2010
    To determine whether interactional group discussions could reduce prescriptions of injections by physicians.
  77. ncbi Early versus late injection medialization for unilateral vocal cord paralysis
    Aaron D Friedman
    Department of Surgery, Harvard Medical School, Center for Laryngeal Surgery and Voice Rehabilitation, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Laryngoscope 120:2042-6. 2010
    ..late (>6 months) injection medialization laryngoplasty impacts the need for subsequent open-neck reconstruction to restore vocal function in patients with unilateral vocal cord paralysis...
  78. ncbi Community-based provision of injectable contraceptives in Madagascar: 'task shifting' to expand access to injectable contraceptives
    Theresa H Hoke
    Family Health International, Research Triangle Park, NC 27709, USA
    Health Policy Plan 27:52-9. 2012
    ..Committed to reducing unmet contraceptive need among remote, rural populations, the Ministry of Health and Family Planning (MOHFP) of Madagascar sought evidence regarding the safety, effectiveness and acceptability of CBD of injectables...
  79. ncbi Intraocular injection of crystalline cortisone as adjunctive treatment of diabetic macular edema
    J B Jonas
    Department of Ophthalmology and Eye Hospital, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Heidelberg, Germany
    Am J Ophthalmol 132:425-7. 2001
    ..To report the clinical outcome of a diabetic patient with macular edema treated with an intravitreal injection of crystalline cortisone...
  80. ncbi Growth factor-based therapies provide additional benefit beyond physical therapy in resistant elbow tendinopathy: a prospective, single-blind, randomised trial of autologous blood injections versus platelet-rich plasma injections
    Leon Creaney
    BUPA Health and Wellbeing, London, UK
    Br J Sports Med 45:966-71. 2011
    ..Two such products; platelet-rich plasma (PRP) and autologous blood, have a growing body of supporting evidence. No previous trial has directly compared the efficacy of these two methods...
  81. ncbi Population beliefs about the efficacy of injections in Pakistan's Sindh province
    Naveed Z Janjua
    Department of Community Health Sciences, Aga Khan University, Stadium Road, Karachi 74800, Pakistan
    Public Health 120:824-33. 2006
    ..We conducted this study to identify factors associated with receiving at least one injection during the past 3 months in an urban and a rural area in the Sindh province of Pakistan...
  82. ncbi Efficacy of intravitreal bevacizumab for polypoidal choroidal vasculopathy
    F Gomi
    Department of Ophthalmology, Osaka University Medical School, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Br J Ophthalmol 92:70-3. 2008
    The aim of the study was to assess the short-term efficacy of intravitreal injections of bevacizumab for polypoidal choroidal vasculopathy (PCV).
  83. pmc Ocular side effects associated with peribulbar injections of triamcinolone acetonide for diabetic macular edema
    Emily Y Chew
    National Eye Institute National Institutes of Health, Bethesda, Maryland, USA
    Retina 31:284-9. 2011
    To evaluate long-term effects of anterior and posterior peribulbar injections of triamcinolone acetonide on intraocular pressure (IOP) elevation and cataract development.
  84. ncbi [Application status and safety countermeasures of traditional Chinese medicine injections]
    Xing jiang Xiong
    Department of Cardiology, Guang anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China
    Zhong Xi Yi Jie He Xue Bao 8:307-11. 2010
    The research and development of traditional Chinese medicine (TCM) injections is an important innovation of modernization of TCM, which has great clinical value and irreplaceability in medical enterprise of China...
  85. ncbi Pain assessment by children and adolescents during intraosseous anaesthesia using a computerized system (QuickSleeper)
    Jean Louis Sixou
    Department of Paediatric Dentistry, UFR d Odontologie de l Université de Rennes 1 and CHU de Rennes, 35043 Rennes Cedex, France
    Int J Paediatr Dent 19:360-6. 2009
    Intraosseous (IO) anaesthesia has been shown to be effective in children. However, the pain associated with anaesthetic injections, and its acceptance by children, have never been studied.
  86. ncbi Single injection peribulbar anesthesia with a short needle combined with digital compression
    Waleed Riad
    Department of Anaesthesia, King Khaled Eye Specialist Hospital, P O Box 7191, Riyadh 11462, Kingdom of Saudi Arabia
    Anesth Analg 107:1751-3. 2008
    ..We compare the efficacy of using a 15 mm to the standard 25 mm needle for performing peribulbar blockade...
  87. ncbi A 5-year assessment of safety and aesthetic results after facial soft-tissue augmentation with polyacrylamide hydrogel (Aquamid): a prospective multicenter study of 251 patients
    Norbert Pallua
    Department of Plastic and Reconstructive Surgery, Hand Surgery Burn Center, University Hospital of the RWTH, Aachen, Germany
    Plast Reconstr Surg 125:1797-804. 2010
    ..To evaluate the safety and efficacy of the material, the manufacturer initiated in 2001 a prospective clinical trial with a follow-up of 5 years. This represents one of the longest running studies on currently used fillers...
  88. ncbi Peripheral nerve blocks and trigger point injections in headache management - a systematic review and suggestions for future research
    Avi Ashkenazi
    Neurologic Group of Bucks Montgomery County, Doylestown, PA, USA
    Headache 50:943-52. 2010
    Interventional procedures such as peripheral nerve blocks (PNBs) and trigger point injections (TPIs) have long been used in the treatment of various headache disorders...
  89. ncbi Comparative vaccine-specific and other injectable-specific risks of injection-site sarcomas in cats
    Anup Srivastav
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA
    J Am Vet Med Assoc 241:595-602. 2012
    ..To compare associations between vaccine types and other injectable drugs with development of injection-site sarcomas in cats...
  90. ncbi Intravitreal and orbital floor triamcinolone acetonide injections in noninfectious uveitis: a comparative study
    Martin Roesel
    Department of Ophthalmology, St Franziskus Hospital, University Duisburg Essen, DE 48145 Münster, Germany
    Ophthalmic Res 42:81-6. 2009
    ..To compare the effect of orbital floor (OFTA) or intravitreal (IVTA) administration of triamcinolone acetonide on visual acuity and chronic cystoid macular edema (CME) in patients with uveitis...
  91. ncbi Repeated injections of botulinum toxin-A for idiopathic detrusor overactivity
    Arun Sahai
    Department of Urology, Guy s Hospital and King s College London School of Medicine, London, United Kingdom
    Urology 75:552-8. 2010
    To report the efficacy and safety of repeated injections of botulinum toxin-A (BTX-A) in treating idiopathic detrusor overactivity refractory to anticholinergics...
  92. ncbi Second-look endoscopy with thermal coagulation or injections for peptic ulcer bleeding: a meta-analysis
    Kelvin K F Tsoi
    Institute of Digestive Disease, Chinese University of Hong Kong, Hong Kong, China
    J Gastroenterol Hepatol 25:8-13. 2010
    ..of peptic ulcer bleeding, the benefits of second-look endoscopic treatment with thermal coagulation or injections in controlling recurrent bleeding is unsure...
  93. ncbi Twelve-year survey of fatal reactions to allergen injections and skin testing: 1990-2001
    David I Bernstein
    Division of Immunology Allergy, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0563, USA
    J Allergy Clin Immunol 113:1129-36. 2004
    ..Fatal reactions associated with skin testing and injection immunotherapy have not been surveyed in North America since 1989...
  94. ncbi Subconjunctival and intracorneal bevacizumab injection for corneal neovascularization in lipid keratopathy
    Joo Youn Oh
    Department of Ophthalmology, Seoul National University College of Medicine, Seoul 110 744, Korea
    Cornea 28:1070-3. 2009
    The purpose of this study was to evaluate the efficacy and safety of subconjunctival and corneal intrastromal bevacizumab injections on corneal neovascularization in patients with lipid keratopathy.
  95. pmc Degradation, cytotoxicity, and biocompatibility of NIPAAm-based thermosensitive, injectable, and bioresorbable polymer hydrogels
    Zhanwu Cui
    The School of Biological and Health Systems Engineering, Center for Interventional Biomaterials, Arizona State University, Tempe, Arizona 85287 9709, USA
    J Biomed Mater Res A 98:159-66. 2011
    ..2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2011...
  96. ncbi Computer-controlled delivery versus syringe delivery of local anesthetic injections for therapeutic scaling and root planing
    Peter M Loomer
    Department of Stomatology, University of California, San Francisco School of Dentistry, 94143, USA
    J Am Dent Assoc 135:358-65. 2004
    ..The anterior middle superior alveolar, or AMSA, injection was compared with other maxillary injections.
  97. ncbi Ongoing positive effect of platelet-rich plasma versus corticosteroid injection in lateral epicondylitis: a double-blind randomized controlled trial with 2-year follow-up
    Taco Gosens
    Department of Orthopaedic Surgery, St Elisabeth Hospital, Tilburg, The Netherlands
    Am J Sports Med 39:1200-8. 2011
    ..Platelet-rich plasma (PRP) has been shown to be a general stimulation for repair and 1-year results showed promising success percentages...
  98. ncbi HIV incidence and recent injections among adults in rural southwestern Uganda
    Jimmy A Whitworth
    Medical Research Council Programme on AIDS, Uganda Virus Research Institute, Entebbe, Uganda
    AIDS 21:1056-8. 2007
    ..HIV cases were matched for age, sex and time period with 36 controls to examine associations with recent injections. A significant association between HIV incidence and a history of injections was detected that was not reduced ..
  99. ncbi Comparison of initial cell retention and clearance kinetics after subendocardial or subepicardial injections of endothelial progenitor cells in a canine myocardial infarction model
    Andrea J Mitchell
    Department of Medical Biophysics, University of Western Ontario, Ontario, Canada
    J Nucl Med 51:413-7. 2010
    ..Direct routes appear preferable. However, most prior studies have used epicardial injections, which are not practical for routine clinical use...
  100. ncbi Safety and efficacy of intravitreal anti-VEGF injections for age-related macular degeneration
    V Swetha E Jeganathan
    Centre for Eye Research Australia, University of Melbourne, Victoria, Australia
    Curr Opin Ophthalmol 20:223-5. 2009
    To report the safety and efficacy of intravitreal injections for age-related macular degeneration (AMD).
  101. pmc Intra-myocardial biomaterial injection therapy in the treatment of heart failure: Materials, outcomes and challenges
    Devin M Nelson
    Department of Bioengineering, University of Pittsburgh, PA 15219, USA
    Acta Biomater 7:1-15. 2011
    ....

Research Grants81

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..Objectives: - To compare the effectiveness of ranibizumab and bevacizumab injections for diabetic macular edema...
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..Objectives: - To compare the effectiveness of ranibizumab and bevacizumab injections for diabetic macular edema...
  3. Principles of Therapy in Cerebellar Disease: Explorations in Ion Channel Mutants
    JOHN SAMUEL STAHL; Fiscal Year: 2013
    ..We will record eye movements in tottering following systemic and intrafloccular injections of 4- aminopyridine...
  4. Autonomic and Antihypertensive Actions of Neuronal CGRP/RAMP1 Receptors
    Mark W Chapleau; Fiscal Year: 2013
    ..mice using the nervous system-specific nestin Cre-recombinase to globally target the nervous system and local injections of viral vectors expressing Cre-recombinase to target specific brain regions including brainstem, subfornical ..
  5. Axonopathy in Glaucoma
    Samuel D Crish; Fiscal Year: 2013
    ..to neurobiological outcome measures including: 1) loss of anterograde axonal transport using intravitreal injections of the sensitive neuronal tracer cholera toxin beta subunit (CTB), and 2) axonal degeneration - ..
  6. Controlling Radiation Injury by TLR5 Agonists
    Andrei V Gudkov; Fiscal Year: 2012
    ..named CBLB502, is a powerful radioprotectant and mitigator of radiation injury suitable for intramuscular injections. It is a polypeptide derived from bacterial protein flagellin that acts as an agonist of Toll-like receptor 5 (..
  7. Nanopolymersomes for Transcutaneous Co-Delivery of Vaccine Antigens and Adjuvants
    PAUL CAMILLE TUMEH; Fiscal Year: 2013
    ..The World Health Organization estimates that 5-10% percent of the 16 billion injections administered worldwide each year are given for immunization...
  8. Steroid Responsive Mechanisms in the Ear
    DENNIS ROYAL TRUNE; Fiscal Year: 2012
    ..Finally, the functional impact of middle ear injections versus systemic delivery will be compared to determine the ability of each method to control glucocorticoid and ..
  9. Cre, Dre Dual Lineage Model for Calcium Imaging and Optogenetic Manipulations
    Petr Tvrdik; Fiscal Year: 2013
    ..populations, such as specific neurons and glia, without any confounding issues of dye loading efficiency, viral injections, etc., because all the required tools can be brought together by breeding...
  10. Therapeutic Effect of a Novel Antioxidant on Degenerative Eye Disorders
    Nuran Ercal; Fiscal Year: 2012
    ..Aims of the proposed research are to evaluate 1) cataract formation in male Wistar rat pups receiving selenite injections and 2) retinal degeneration in rd10+/+ and Ccl2-/- mice that spontaneously develop progressive photoreceptor ..
  11. Mechanisms of Angiogenesis in Retinopathy of Prematurity
    Mary Elizabeth Hartnett; Fiscal Year: 2009
    ..of microRNAs to VEGFA or VEGF164 packaged into lentiviral vectors with a CD44 promoter;subretinal injections;systemic NADPH oxidase inhibitors or clodronate;measurement of reactive oxygen species (e.g...
  12. Effectivenss of a New Non-Invasive Erectile Support System in Aging Populations
    S ALEXANDER WEINSTOCK; Fiscal Year: 2012
    ..still controversial prescribed pills, and more invasive treatments including, transurethral inserts, penile injections, and penile implants...
  13. Mechanisms of Angiogenesis of Retinopathy of Prematurity
    MARY ELIZABETH RUTH HARTNETT; Fiscal Year: 2013
    ..of microRNAs to VEGFA or VEGF164 packaged into lentiviral vectors with a CD44 promoter;subretinal injections;systemic NADPH oxidase inhibitors or clodronate;measurement of reactive oxygen species (e.g...
  14. Controlled delivery of polypeptide hormone calcitonin
    Jagdish Singh; Fiscal Year: 2013
    ..Currently, multiple injections of calcitonin is a common practice in treating the above conditions due to its short biological half-life...
  15. Neuropeptide modulation of biogenic amine function and aggression in a crustacean
    Maria A Sosa; Fiscal Year: 2013
    ..To achieve these aims, we will use techniques of behavioral observation and quantitation before and after injections of agents of interest, CNS dissection, immunohistochemistry, confocal microscopy, hemolymph sampling and ..
  16. Environmental regulation of estrogen dependent aggression
    Brian C Trainor; Fiscal Year: 2013
    ..This suggests that estrogens may decrease aggression by driving transcription. In short day's estradiol injections increase aggression within 15 minutes, suggesting these effects are mediated by nongenomic pathways...
  17. Epithelial Sodium Channels in the Supraoptic Vasopressin and Oxytocin Neurons
    Ryoichi Teruyama; Fiscal Year: 2009
    ..2005). Intracerebroventricular injections of the ENaC blocker, the amiloride analogue benzamil, significantly attenuated the hypertension in animal models ..
  18. Pharmacological strategies to improve breathing after cervical spinal cord injury
    FRANCIS GOLDER; Fiscal Year: 2009
    ..Demonstrating clear translational potential, intraperitoneal injections of CGS 21680 also elicits long-lasting improvements in tidal volume in awake rats with cervical SCI...
  19. Long-Acting G-CSF Analog for Treating ARS
    GEORGE NORBERT COX; Fiscal Year: 2013
    ..Our long-acting G-CSF analog also improved survival compared to placebo following multiple injections into irradiated mice...
  20. Regulation of factor VIII Levels and Activity by Members of LDL Receptor Family
    Dudley K Strickland; Fiscal Year: 2013
    ..Hemophilia A is associated with deficiency of coagulation factor VIII (fVIII) and is treated by repeated injections of exogenous fVIII. Replacement therapy remains expensive and is estimated as up to $200,000/adult patient/year...
  21. VEGF Regulation of Hepatic Erythropoietin Synthesis
    Calvin Kuo; Fiscal Year: 2009
    ..Single injections in mice of these adenoviruses produce high levels of circulating soluble Flk1 and Flt1 ectodomains which persist ..
  22. A Cis-regulatory Model for Neural Border Induction
    Daniel Meulemans Medeiros; Fiscal Year: 2013
    ..The proposed work will test this model using mRNA injections, mutagenesis, and chromatin immunoprecipitation (ChIP)...
  23. The lymph node microenvionment in tumor metastasis
    Judith A Varner; Fiscal Year: 2012
    ..In contrast, stimulation of lymph node lymphangiogenesis by injections of VEGF-C accelerates metastasis to stimulated lymph nodes...
  24. Development of a Porcine Model of Ataxia-Telangiectasia
    Christopher Rogers; Fiscal Year: 2011
    ..Physical and speech therapy may improve the daily lives of patients, and 3-globulin injections can be given to support the immune system. However, no treatment is currently directed at the underlying defect...
  25. Molecular Mechanisms of Gastrin Mediated Pathways in Gastric Cancer Cells
    Basabi Rana; Fiscal Year: 2013
    ..luciferase and kinase assays, immunoprecipitation, SiRNA technology, subcutaneous xenografts and tail vein injections. Significance of potential new findings: The fact that hypergastrinemia promotes tumor progression poses a major ..
  26. Gold Nanoparticle Assisted Delivery of Cancer Vaccines and Immune Stimulants
    Adam Lin; Fiscal Year: 2013
    ..and tend to stay at injection sites while smaller nanoparticles drain into lymph nodes with subcutaneous injections. They also have known toxicities post degradation...
  27. Mechanisms of structural plasticity in stress-related disorders
    Scott J Russo; Fiscal Year: 2013
    ..Although the biochemical mechanisms of NF?B mediated spine alterations are unknown, intracranial injections of the HSV-IKK mutants into the NAc resulted in gross changes in Rac1-PAK1 signaling, a RhoGTPase pathway known ..
  28. Epigenetics and choline: mediation of fetal alcohol effects in a rat model
    Carol L Cheatham; Fiscal Year: 2013
    ..This diet will be important in the avoidance of the stress of injections that is inherent in cholin administration...
  29. Modeling schizophrenia gamma deficits using cell-specific RNAi knockdown of GAD67
    RITCHIE EDWARD BROWN; Fiscal Year: 2012
    ..To achieve cell-type and region specificity, injections of viral vectors (adeno-associated virus;AAV) with Cre recombinase-dependent expression of small hairpin RNA ..
  30. Prevention of Esophageal Cancer with Berries
    Gary Stoner; Fiscal Year: 2013
    ..In the rat, esophageal tumors are induced within 25-30 weeks by repeated s.c. injections of the N-nitrosamine carcinogen, N-nitrosomethylbenzylamine (NMBA)...
  31. Development of a Porcine Model of Ataxia-Telangiectasia
    Christopher Rogers; Fiscal Year: 2013
    ..Physical and speech therapy can improve the lives of patients, and [unreadable]-globulin injections can be given to support the immune system. However, no treatment is directed at the underlying defect...
  32. Prevention and Treatment of Chlorine Gas Induced Injury to the Pulmonary System
    Sadis Matalon; Fiscal Year: 2011
    ..5, 6, 12, 24 and 48 h post exposure. These measurements will be repeated following intravenous injections of NAC, ascorbate and deferoxamine as well as albuterol and the tip peptide, every 6 h post exposure for 48 h...
  33. The Role of Cyp2b in Toxicant Metabolism and Sensitivity
    William S Baldwin; Fiscal Year: 2012
    ..Last, recent preliminary data following ip injections with TCPOBOP or corn oil as a carrier revealed that Cyp2b-KD mice but not wild-type mice are unable to properly ..
  34. Delayed pubertal development on the mechanism of bone loss at maturity
    Vanessa R Yingling; Fiscal Year: 2011
    ..Pubertal delay will be completed by gonadotropin releasing hormone antagonist 21 (GnRH-antagonist) injections. At 50 days of age changes in bone morphology will be evaluated using a novel 22 3D texture analysis...
  35. Serotonin Receptor Modulation of Neurotrophic Factors in the Retina
    Mark E Pennesi; Fiscal Year: 2013
    ..have been shown to prevent photoreceptor death in animal models of RP13-17, but such treatments require frequent injections or implanted drug release systems...
  36. Novel Glycosaminoglycan Ethers for Prevention of Metastasis
    Alana L Welm; Fiscal Year: 2011
    ..therapeutic window, showing intravenous safety even as high as 100 mg/kg single injection or daily 10 mg/kg injections. In this Phase I SBIR project, we will establish the feasibility of using subcutaneous SAGEs as simple anti-..
  37. Selenoprotein K modulates calcium-dependent signaling in immune cells
    PETER R HOFFMAN; Fiscal Year: 2013
    ..An established protocol will be utilized to infect these mice with footpad injections of WNV...
  38. Cell Specific Expression in the Pituitary Gland
    Sally A Camper; Fiscal Year: 2013
    ..Treatment involves hormone replacement therapy, which can involve daily injections of recombinant growth hormone at great expense per patient...
  39. Treatment of Acute Coronary Syndromes with Recombinant LCAT Infusion
    BRIAN ROBERT KRAUSE; Fiscal Year: 2011
    ..Multiple injections of rhLCAT over several days produced even greater increases in HDL-C, and resulted in enhanced expression of ..
  40. Delivery of biologically active nucleic acids to epidermal cells
    ROGER L contact KASPAR; Fiscal Year: 2010
    ..Intradermal injections appear to deliver nucleic acids to epidermal cells, but the large cutaneous surface makes such an approach ..
  41. Enhancing Plasticity in Damaged Spinal Cord to Repair Transmission and Function
    Victor L Arvanian; Fiscal Year: 2013
    ..combine Ch-ABC treatment with (i) AAV-mediated transgene delivery of NT-3 (AAV-NT3;intraspinal and intrathecal injections;AAV-mediated gene delivery has been found to be safe in multiple clinical trials) and (ii) repetitive electro-..
  42. Development of Transdermal Films for the the Delivery of HIV Therapeutics
    Anthony Sang Won Ham; Fiscal Year: 2010
    ..Through conventional administration, such as injections or oral, PYD would be subjected to extensive first pass metabolism by the liver limiting its effectiveness...
  43. Feedback and Hormonal Regulation of Hepatic HMG-CoA Reductase
    GENE CHARLES NESS; Fiscal Year: 2010
    ..will be examined by either over expressing hepatic HMGR or by knocking it down with hydrodynamic tail vein injections of plasmids containing HMGR cDNA or siRNA...
  44. Systemic Application for Injury Site Specific Delivery via Neutrophils to Treat B
    XUDONG J LI; Fiscal Year: 2013
    ..As such, the use of fluoroscopy-guided lumbar epidural injections of steroids to reduce the local chemo-inflammatory response has increased dramatically since their inception as ..
  45. Protein Therapy for Recessive Dystrophic Epidermolysis Bullosa
    David T Woodley; Fiscal Year: 2010
    ..With C7 protein therapy, we showed that intradermal injections of recombinant C7 into human RDEB skin equivalents transplanted onto athymic mice stably restored C7 expression ..
  46. Development of Small Heat Shock Proteins as Therapeutic Agents in the Eye
    JONATHAN MARK PETRASH; Fiscal Year: 2010
    ..for long-term therapy while at the same time minimizing risks and costs associated with repeated intraocular injections. It is likely that drugs intended for treating degenerative disorders of the eye should be administered from the ..
  47. Mammary Gland Morphogenesis and Breast Cancer
    Ian G Macara; Fiscal Year: 2013
    ..to manipulate gene expression in primary cells, which are tested using the in vivo transplant model, tail vein injections, and in vitro mammosphere cultures. 3...
  48. Diet, Insulin, Dopamine, and Reward.
    Margaret E Rice; Fiscal Year: 2013
    ..experiments in Aim 3 will determine the effect of intrastriatal insulin and insulin receptor (InsR) antagonist injections on behavioral responses to rewarding brain stimulation and food- and drug-paired environments...
  49. Neurobiological mechanisms of nicotine reinforcement: Role of the nucleus tractus
    LUIS MIGUEL TUESTA; Fiscal Year: 2012
    ..Preliminary data show that GLP-1 neurons in the NTS are activated in response to acute nicotine injections. In addition, preliminary studies suggest that nicotine IVSA is almost completely abolished in mice lacking ..
  50. Oral immune modulatory therapy using antigens bioencapsulated in plant cells
    Roland W Herzog; Fiscal Year: 2013
    ..delivery of therapeutic protein antigens without a need for fermentation, purification, cold chain, or sterile injections. Bioencapsulated antigens are protected in the stomach from acids or enzymes, but are released in the gut when ..
  51. Auditory Neuroprotection by Small Molecule Agonists of the TrkB Receptor
    Keqiang Ye; Fiscal Year: 2013
    ..this project, we have obtained preliminary data showing that systemic application of 7,8-DHF by intraperitoneal injections dramatically protected SG neurons from degeneration without any obvious side effects in mice...
  52. Treating cutaneous leishmaniasis by radio-frequency induced heat (RFH) therapy
    Abhay R Satoskar; Fiscal Year: 2012
    ..recommended treatment for CL world-wide, but they are toxic, and compliance with treatment is poor because daily injections for 3 weeks or longer are required...
  53. Translating a CSF delivered AAV9-SMN for treatment of Spinal Muscular Atrophy
    Brian K Kaspar; Fiscal Year: 2013
    ..When virus is delivered to the CSF, via intraventricular injections, we and others13,17 have demonstrated that SMA mice survive significantly longer, greater than 100 days of age, ..
  54. Chronic Toll-like Receptor Ligation and Hematopoietic Stem Cell Aging
    Brandt L Esplin; Fiscal Year: 2010
    ..Daily intraperitoneal injections with LPS or Pam3CSK4 will be used to model chronic infection...
  55. Genetic Regulation of Rhombomere Formation
    CHARLES G SAGERSTROM; Fiscal Year: 2013
    ..knock-down, zinc-finger nuclease-mediated targeted deletions), as well as misexpression approaches (mRNA injections, GAL4:UAS transgenesis), to determine the function of these genes...
  56. Randomized Trial of Antenatal Late Preterm Steroids (ALPS) - Clinical Coordinatin
    Ronald Wapner; Fiscal Year: 2012
    ..Eligible and consenting women will be randomized to a course of two intramuscular injections containing 12 mg of betamethasone, 24 hours apart or to a similar course of an identically appearing placebo...
  57. Structural and Functional Changes in Myopia and Susceptibility to Glaucoma
    Lisa Ostrin; Fiscal Year: 2013
    ..myopic eyes are more susceptible to glaucoma, IOP will be elevated in normal and myopic eyes using intracameral injections of microbeads (the Microbead Occlusion Model), and its effects on structure and function evaluated...
  58. AAV vectors for retinal delivery in a mouse model of age-related retinopathy
    KATHARINE LIANG; Fiscal Year: 2013
    ..The field is currently impeded by a reliance on subretinal injections, which are invasive and deliver therapeutics to a limited area in the retina...
  59. Sphingosine 1-Phosphate: A New Target for Early Diabetic Retinopathy
    Arup Das; Fiscal Year: 2013
    ..the majority of patients do not recover vision, and the effect is transient, needing repeated intravitreal injections of drugs...
  60. Development of a Human Hydrolase to Treat Cocaine Abuse and Overdose: Rat Models
    WILLIAM STEPHEN BRIMIJOIN; Fiscal Year: 2011
    ..b>Injections of this protein hastened drug elimination 100-fold or more, prevented toxicity from a lethal dose of cocaine ..
  61. Leads and Target Validation for Vascular Calcification in Chronic Kidney Disease
    Jose Luis Millan; Fiscal Year: 2010
    ..smooth muscle and that medial calcification in uremic rats and in mouse models of PPi-deficiency is prevented by injections of PPi...
  62. Long-acting Growth Hormone for Treating HIV-Associated Adipose Redistribution Syn
    George Cox; Fiscal Year: 2009
    ..The improved in vivo characteristics of this novel GH analog will reduce the need for frequent injections, improve patient quality of life and potentially lead to a more effective therapy for the treatment of HARS...
  63. Transscleral Transport & Polymeric Delivery of Antibody & Steroids for Macular Ed
    Ashim K Mitra; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Repeated intravitreal injections of steroids and anti-VEGF agents in the treatment of macular edema, pose potential post-surgical problems...
  64. HYALURONIC ACID/TGF-B COMPOSITE TO TREAT OSTEOARTHRITIS
    STEVEN KINCAID; Fiscal Year: 1991
    ..Treatment of osteoarthritic joints with injections of hyaluronic acid has proven to provide short term improvement of clinical signs possibly because of its ..
  65. Cortical contributions to basal ganglia disorders
    PETER STRICK; Fiscal Year: 2006
    ..These injections produce reversible dyskinesias, hyperactivity, attention deficits or stereotypes, depending upon the location of ..
  66. PREVENTING CONTRAST-INDUCED NEPHROPATHY
    Ali Hassan; Fiscal Year: 2009
    ..procedures such as stent implantation, angioplasty, and diagnostic angiography require frequent and large injections of radiopaque contrast agents in order to visualize the blood vessels...
  67. Topical Nanoparticles for CNV
    Uday B Kompella; Fiscal Year: 2010
    ..Current therapeutic management of AMD is far from optimal and requires repeated injections in the vitreous cavity of the eye...
  68. Modulation of Pruritus by Spinal Cannabinoids
    Gregory W Terman; Fiscal Year: 2010
    ..nociception, itch sensation, also appears to be increased in animals previously exposed to repeated morphine injections - although this effect is largely masked by concurrent spinal endocannabinoid inhibition...
  69. A Bi-Institutional Pilot Study of Vaccinations for Patients with Low Grade Glioma
    Edward G Shaw; Fiscal Year: 2010
    ..Institute and the Comprehensive Cancer Center of Wake Forest University of a vaccination regime (subcutaneous injections of glioma-associated antigen [GAA]-derived cytotoxic T-lymphocyte [CTL] epitope-peptides with simultaneous ..
  70. Novel Adeno-Associated Viral Therapy for Wet Age-Related Macular Degeneration
    James M Wilson; Fiscal Year: 2012
    ..The standard of care for wet AMD is repeated intraocular injections of vascular endothelial growth factor (VEGF) inhibitors, including the monoclonal antibody fragment ranibizumab...
  71. Back pain Outcomes using Longitudinal Data (BOLD)
    Jeffrey G Jarvik; Fiscal Year: 2010
    ..patients with spinal stenosis to evaluate the effectiveness, cost and safety of combined epidural steroid injections and local anesthetics compared with local anesthetic injections alone, and 2) a prospective observational cohort ..
  72. 5-FLUOROURACIL & GLAUCOMA FILTERING SURGERY
    Dale Heuer; Fiscal Year: 1992
    ..a multicenter randomized clinical trial, began in September 1985, to determine if postoperative subconjunctival injections of 5-fluorouracil (5- FU) would increase the success rate of glaucoma filtering surgery in patients with poor ..
  73. Islet Protection from Hypoxia Posttransplant
    Klearchos K Papas; Fiscal Year: 2010
    ..Oral administration, if effective, would provide a preferred, more practical and safer alternative to injections. The objectives of this Phase I STTR are to: (i) Determine whether the succinate esters of alpha- plus gamma-..
  74. Dopamine D2 and Adenosine A2A roles:Tremulous Movements
    John Salamone; Fiscal Year: 2007
    ..In a recent study from our laboratory, it was demonstrated that IP injections of the adenosine A2A antagonist, KF17837, also suppressed haloperidol-induced tremulous jaw movements, and ..
  75. Immunomodulatory Mechanisms of Sublingual Immunotherapy
    Louis Rosenthal; Fiscal Year: 2006
    ..sensitization is allergen-specific subcutaneous immunotherapy (SCIT), which involves a series of subcutaneous injections of allergen extracts...
  76. Peripheral and Central Mechanism of Pain in Patients with Fibromyalgia
    ROLAND M STAUD; Fiscal Year: 2010
    ..In the second Specific Aim we will study the analgesic mechanisms of FM subjects related to injections of lidocaine or saline placebo into painful trapezius muscle (TrapM) tender points (analgesia)...
  77. ANATOMY OF IDENTIFIED CELL POPULATIONS IN VISUAL CORTEX
    BARBARA MC GUIRE; Fiscal Year: 1991
    ..cell biological techniques of tissue slice preparations, fluorescence tracing methods and intracellular dye injections. By focusing on a few specific cell populations, it will be possible to fully characterize individual cell types ..
  78. Daily genistein injections stimulate intestinal secretion: How?
    Layla Al Nakkash; Fiscal Year: 2007
    ..In normal wild-type (Wt) female mice, we tested intestinal function after 2 weeks of daily genistein injections (600 mg/kg body weight) and compared to genistein-free injected (vehicle control) mice...
  79. Increased vulnerability of BDNF deficient mice to mild stress
    JULIE GORTON HENSLER; Fiscal Year: 2010
    ..of responses to repeated stress, we hypothesize that mice deficient in BDNF will not habituate to repeated injections of saline...
  80. STRESS GENES AND HEMORRHAGIC BRAIN INJURY
    Frank Sharp; Fiscal Year: 2001
    ..Subarachnoid injections of whole blood, lysed blood or hemoglobin induce hemeoxygenase-1 (HO-1) in microglia throughout the entire brain...