Genomes and Genes
drug administration routes
Summary: The various ways of administering a drug or other chemical to a site in a patient or animal from where the chemical is absorbed into the blood and delivered to the target tissue.
Publications244 found, 100 shown here
- Neurosteroid allopregnanolone mediates anxiolytic effect of etifoxine in ratsRajesh R Ugale
Pharmacology Division, Shrimati Kishoritai Bhoyar College of Pharmacy, New Kamptee 441 002, Nagpur, Maharashtra, India
Brain Res 1184:193-201. 2007..Thus, our results provide behavioral evidence for the role of neurosteroids like ALLO in the anti-anxiety effect of etifoxine...
- Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative diseaseLeah R Hanson
Alzheimer s Research Center at Regions Hospital, HealthPartners Research Foundation, 640 Jackson Street, St, Paul, MN 55101, USA
BMC Neurosci 9:S5. 2008..This new method of delivery can revolutionize the treatment of Alzheimer's disease, stroke, and other brain disorders...
- Delivery of NGF to the brain: intranasal versus ocular administration in anti-NGF transgenic miceSimona Capsoni
Lay Line Genomics S p A, Rome, Italy
J Alzheimers Dis 16:371-88. 2009..The ocular administration of hNGF-61 showed a more limited efficacy, even at higher doses. Thus, NGF nasal drops represent a viable and effective option to successfully deliver therapeutic NGF to the brain in a non-invasive manner...
- Size-dependent disposition of nanoparticles and microparticles following subconjunctival administrationAniruddha C Amrite
Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE 68198 6025, USA
J Pharm Pharmacol 57:1555-63. 2005..Periocular administration of particulate systems of this size would likely be useful as sustained drug delivery systems...
- A 10 year retrospective audit of long-term apomorphine use in Parkinson's diseaseHilary L Tyne
The University of Liverpool, UK
J Neurol 251:1370-4. 2004..We have examined our experience of apomorphine over the last 10 years, to assess indications, pattern of use, efficacy, and side effect profile...
- The acceptability of different routes of administration of analgesia for breakthrough painG Walker
Palliative Care Cancer Unit, Nottingham City Hospital NHS Trust, Nottingham, UK
Palliat Med 17:219-21. 2003
- Long-term 24-hour duodenal infusion of levodopa: outcome and dose requirementsDag Nyholm
Department of Neuroscience, Neurology, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
Neurology 65:1506-7. 2005
- Continuous apomorphine infusion and neuropsychiatric disorders: a controlled study in patients with advanced Parkinson's diseaseA E Di Rosa
Department of Neuroscience, University of Messina, Via Consolare Valeria, Messina, Italy
Neurol Sci 24:174-5. 2003..The neuropsychiatric assessment did not change in both groups compared with baseline, except for a significant improvement of mood in the apomorphine group...
- Opioid delivery in the treatment of cancer breakthrough pain: a review of routes of administrationBruce Nicholson
Division of Pain Medicine, Pain Specialists of Greater Lehigh Valley, Pennsylvania, USA
J Opioid Manag 7:69-79. 2011..The purpose of this review is to provide an overview of the different routes of opioid administration used in the treatment of cancer BTP and briefly discuss the characteristics of different delivery systems...
- Development of a non invasive NGF-based therapy for Alzheimer's diseaseSonia Covaceuszach
Lay Line Genomics S p A, Rome, Italy
Curr Alzheimer Res 6:158-70. 2009..The development of hNGF-61 towards clinical applications in AD patients is under way...
- Immunization by a bacterial aerosolLucila Garcia-Contreras
University of North Carolina, Chapel Hill, NC 27599 7360, USA
Proc Natl Acad Sci U S A 105:4656-60. 2008....
- Methadone antinociception is dependent on peripheral opioid receptorsLi He
Ernest Gallo Clinic and Research Center and the Department of Neurology, University of California, San Francisco, Emeryville, CA 94608, USA
J Pain 10:369-79. 2009....
- Prime-boost vaccination using recombinant Mycobacterium bovis BCG and recombinant vaccinia virus DIs harboring HIV-1 CRF01_AE gag in mice: influence of immunization routesDuanthanorm Promkhatkaew
Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand
Southeast Asian J Trop Med Public Health 40:273-81. 2009..d. could be used to elicit prolonged CTL responses as well as memory T-cells in mice, which might be more practical than using i.v. route...
- Intra-amniotic endotoxin increases pulmonary surfactant proteins and induces SP-B processing in fetal sheepC J Bachurski
Division of Pulmonary Biology, Children s Hospital Research Foundation, Cincinnati, Ohio 45229, USA
Am J Physiol Lung Cell Mol Physiol 280:L279-85. 2001..IA endotoxin caused rapid and sustained increases in SP mRNAs that preceded the increase in alveolar saturated phosphatidylcholine processing of SP-B and improved lung compliance in prematurely delivered lambs...
- Off-label use of medicines in children: can available evidence avoid useless paediatric trials? The case of proton pump inhibitors for the treatment of gastroesophageal reflux diseaseGiovanni Tafuri
Utrecht Institute for Pharmaceutical Sciences, Utrecht University, P O Box 80 082, 3508 TB, Utrecht, The Netherlands
Eur J Clin Pharmacol 65:209-16. 2009..In some cases of drug therapy, the available evidence might be sufficient to extend the indications to children without further clinical studies...
- Central cyclooxygenase inhibitors reduced IL-1beta-induced hyperalgesia in temporomandibular joint of freely moving ratsDong K Ahn
Department of Oral Physiology, School of Dentistry, Kyungpook National University, 188 1 Sam Deok 2 ga, Chung gu, Daegu 700 412, South Korea
Pain 117:204-13. 2005..It is concluded that central acting of COX-3 inhibitors may be of therapeutic value in the treatment of inflammatory pain in TMJ...
- The role of methadone in cancer pain treatment--a reviewW Leppert
Department of Palliative Medicine, Poznan University of Medical Sciences, Poznan, Poland
Int J Clin Pract 63:1095-109. 2009..Methadone is an opioid analgesic of step 3 of the World Health Organization (WHO) analgesic ladder...
- Pharmacokinetics of intraocular drug delivery by periocular injections using ocular fluorophotometryDeepta Ghate
Emory University Eye Center, Atlanta, Georgia 30322, USA
Invest Ophthalmol Vis Sci 48:2230-7. 2007..To evaluate the pharmacokinetics of the periocular injections: posterior subtenon (PST), retrobulbar (RB), and subconjunctival (SC) injection...
- Enhanced brain targeting efficiency of intranasally administered plasmid DNA: an alternative route for brain gene therapyIn Kwon Han
MyGene Bioscience Institute, Kangnam Gu, Seoul, South Korea
J Mol Med (Berl) 85:75-83. 2007....
- Use of colistin in the treatment of multiple-drug-resistant gram-negative infectionsDavid Berlana
Pharmacy Service, Hospital Universitari de Bellvitge, Barcelona, Spain
Am J Health Syst Pharm 62:39-47. 2005..The use of colistin for the treatment of infections caused by multiple-drug-resistant (MDR) gram-negative microorganisms was studied...
- Oral versus IV treatment for catheter-related bloodstream infectionsBurke A Cunha
Emerg Infect Dis 13:1800-1; author reply 1801. 2007
- Urocortin 2 increases c-Fos expression in topographically organized subpopulations of serotonergic neurons in the rat dorsal raphe nucleusDaniel R Staub
Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK
Brain Res 1044:176-89. 2005....
- Effects of central leptin infusion on the reward-potentiating effect of D-amphetamineJoy Hao
Department of Pharmacology, New York University School of Medicine, New York, NY 10016, USA
Brain Res 1087:123-33. 2006..Together, results of this study support the importance of weight loss, but not leptin, in the enhancement of drug reward sensitivity...
- Analgesic effects of the selective group II (mGlu2/3) metabotropic glutamate receptor agonists LY379268 and LY389795 in persistent and inflammatory pain models after acute and repeated dosingCarrie K Jones
Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
Neuropharmacology 49:206-18. 2005..The present findings indicate that group II (mGluR2/3) metabotropic glutamate receptors may be involved in the mechanisms of hyperalgesia and allodynia, however tolerance rapidly develops to these effects...
- Neuroprotection and functional recovery conferred by administration of kappa- and delta 1-opioid agonists in a rat model of global ischemiaCharlaine Charron
University of Ottawa, School of Psychology, Ottawa, ON, Canada K1N 9A9
Physiol Behav 93:502-11. 2008..Similar to U50,488H, DPDPE had no significant impact on locomotor activity. These findings support a role for kappa- and delta-opioid receptors in attenuation of ischemia-induced hippocampal damage and cognitive impairments...
- 18-MC acts in the medial habenula and interpeduncular nucleus to attenuate dopamine sensitization to morphine in the nucleus accumbensOlga D Taraschenko
Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
Synapse 61:547-60. 2007..The results suggest that 18-MC acts in the habenulo-interpeduncular pathway to modulate the effects of repeated morphine in the dopaminergic mesolimbic system...
- Spinal and local peripheral antiallodynic activity of Ro64-6198 in neuropathic pain in the ratIlona Obara
Department of Molecular Neuropharmacology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343 Krakow, Poland
Pain 116:17-25. 2005..Therefore, besides spinal, also peripheral ORL1 receptors may be targeted by drugs designed for the long-term treatment of chronic pain...
- Antiallodynic effects of NMDA glycine(B) antagonists in neuropathic pain: possible peripheral mechanismsThomas Christoph
Department of Pharmacology, Grünenthal GmbH R and D, Zieglerstr 6, 52078 Aachen, Germany
Brain Res 1048:218-27. 2005..Thus, peripheral NMDA receptors may substantially contribute to the efficacy of NMDA antagonists in neuropathic pain...
- Modulation of NMDA receptors by intrathecal administration of the sensory neuron-specific receptor agonist BAM8-22Tingjun Chen
College of Life Sciences and Provincial Key Laboratory of Developmental Biology Neuroscience, Fujian Normal University Fuzhou, Fujian 350108, People s Republic of China
Neuropharmacology 54:796-803. 2008..Taken together, these data suggest that the activation of SNSR induces spinal analgesia by suppressing NMDA receptor-mediated activation of spinal dorsal horn neurons and an increase in NOS activity...
- Inhibition by spinal mu- and delta-opioid agonists of afferent-evoked substance P releaseIchiro Kondo
Department of Anesthesiology, University of California San Diego, La Jolla, California 92093, USA
J Neurosci 25:3651-60. 2005..All effects were reversed by naloxone. These results indicate that lumbar opiates inhibit noxious stimuli-induced neurotransmitter release from primary afferents at doses that are confirmed behaviorally as analgesic...
- U-69593, a kappa opioid receptor agonist, decreases cocaine-induced behavioral sensitization in female ratsAnabel Puig-Ramos
Department of Physiology, University of Puerto Rico, School of Medicine, San Juan, Puerto Rico
Behav Neurosci 122:151-60. 2008..This decrease in cocaine-induced hyperlocomotion persisted after 1 week of cocaine withdrawal. These data indicate that the KOPr system participates in estradiol modulation of cocaine-induced behavioral sensitization in the female rat...
- Rats maintained chronically on buprenorphine show reduced heroin and cocaine seeking in tests of extinction and drug-induced reinstatementRobert E Sorge
Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, QC, Canada
Neuropsychopharmacology 30:1681-92. 2005....
- Systemic administration of a dopamine, but not a serotonin or norepinephrine, transporter inhibitor reinstates cocaine seeking in the ratHeath D Schmidt
Laboratory of Neuropsychopharmacology, Department of Pharmacology, L 603, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
Behav Brain Res 175:189-94. 2006..These results suggest that increases in extracellular concentrations of dopamine, specifically in the nucleus accumbens shell, are primarily responsible for promoting cocaine priming-induced reinstatement of drug seeking in rats...
- Antihyperalgesic effects of loperamide in a model of rat neuropathic pain are mediated by peripheral delta-opioid receptorsKatsumi Shinoda
Pharmaceutical Research Center, Kyowa Hakko Kogyo Co, Ltd, 1188 Shimotogari, Nagaizumi cho, Sunto gun, Shizuoka ken 411 8731, Japan
Neurosci Lett 411:143-6. 2007....
- Roles of peripheral mitogen-activated protein kinases in melittin-induced nociception and hyperalgesiaJ Hao
Institute for Biomedical Sciences of Pain and Institute for Functional Brain Disorders, Tangdu Hospital, Fourth Military Medical University, 1 Xinsi Road, Baqiao District, Xi an 710038, PR China
Neuroscience 152:1067-75. 2008..However, they are not likely to be involved in the processing of melittin-induced primary mechanical hyperalgesia, implicating a mechanistic separation between mechanical and thermal hyperalgesia in the periphery...
- Cataleptic activity of the denatured venom of the social wasp Agelaia vicina (Hymenoptera, Vespidae) in Rattus norvegicus (Rodentia, Muridae)Luciana de Oliveira
Neurobiology and Venoms Laboratory, Biology Department of the Faculty of Philosophy, Sciences and Literature of Ribeirão Preto, University of Sao Paulo, Ribeirao Preto SP, Brazil
Prog Neuropsychopharmacol Biol Psychiatry 30:198-203. 2006..However, the association of haloperidol and denatured venom was reverted by theophylline but not by ketamine. These findings suggest that A. vicina venom may affect neural substrates involved with catalepsy in the central nervous system...
- DAMGO and 6beta-glycine substituted 14-O-methyloxymorphone but not morphine show peripheral, preemptive antinociception after systemic administration in a mouse visceral pain model and high intrinsic efficacy in the isolated rat vas deferensMahmoud Al-Khrasani
Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary
Brain Res Bull 74:369-75. 2007..Our findings support the role of peripheral MOR in the pathology of pain states involving sensitization of peripheral nociceptors...
- Buprenorphine reduces alcohol drinking through activation of the nociceptin/orphanin FQ-NOP receptor systemRoberto Ciccocioppo
Department of Experimental Medicine and Public Health, University of Camerino, Camerino, Italy
Biol Psychiatry 61:4-12. 2007..Here we evaluated whether buprenorphine, a partial agonist at micro-opioid and NOP receptors, would reduce ethanol consumption in msP rats via activation of NOP receptors...
- Effects of rat/mouse hemokinin-1, a mammalian tachykinin peptide, on the antinociceptive activity of pethidine administered at the peripheral and supraspinal levelCai Yun Fu
Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, Lanzhou University, 222 Tian Shui South Road, Lanzhou 730000, People s Republic of China
Behav Brain Res 184:39-46. 2007..Our results may pave the way for a new strategy for the control of pain and may provide a clinical strategy to enable selection of either opioid as a priority...
- The acute and chronic administration of (+/-)-8-hydroxy-2-(Di-n-propylamino)tetralin significantly alters the activity of spontaneously active midbrain dopamine neurons in rats: an in vivo electrophysiological studyKazuhiko Nakamura
Department of Psychiatry, Hamamatsu University School of Medicine 1 20 1, Handayama, Hamamatsu, 431 3192, Shizuoka, Japan
Synapse 59:359-67. 2006..01 and 0.1 mg/kg, but significantly decreased by 1 mg/kg of 8-OH-DPAT. Overall, the systemic administration of 8-OH-DPAT preferentially affects the activity of spontaneously active A10 DA neurons in rats...
- Peptidic delta opioid receptor agonists produce antidepressant-like effects in the forced swim test and regulate BDNF mRNA expression in ratsMary M Torregrossa
Neuroscience Program, University of Michigan, Ann Arbor, MI 48109, USA
Brain Res 1069:172-81. 2006....
- The role of NR2B containing NMDA receptor in place preference conditioned with morphine and natural reinforcers in ratsYao Ying Ma
Neuroscience Research Institute and Department of Neurobiology, Peking University Health Science Center, Key Laboratory of Neuroscience, The Ministry of Education and Ministry of Public Health, 38 Xueyuan Road, Beijing 100083, PR China
Exp Neurol 200:343-55. 2006..Taking together, these findings suggested that NR2B containing NMDA receptor may be more involved with morphine reward rather than natural rewards, and that antagonism of NR2B may have a potential for the treatment of morphine abuse...
- Ghrelin inhibits inflammatory pain in rats: involvement of the opioid systemValeria Sibilia
Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milano, Via Vanvitelli, 32, 20129 Milan, Italy
Neuropharmacology 51:497-505. 2006..c.), did not antagonize antinociception elicited by i.p. ghrelin. Overall these data indicate that ghrelin exerts an inhibitory role on inflammatory pain through an interaction with the central opioid system...
- Neuroprotection by tamoxifen in focal cerebral ischemia is not mediated by an agonist action at estrogen receptors but is associated with antioxidant activityYonghua Zhang
Neural and Vascular Biology Theme, Ordway Research Institute, 150 New Scotland Avenue, Albany, NY 12208, USA
Exp Neurol 204:819-27. 2007..These data are consistent with at least part of tamoxifen's marked neuroprotection in focal cerebral ischemic injury being due to its antioxidant activity but not by an acute action on estrogen receptors (212 words)...
- Pretreatment with subeffective doses of Rimonabant attenuates orexigenic actions of orexin A-hypocretin 1Inmaculada Crespo
Departamento de Psicobiologia, Facultad de Psicologia, Universidad Complutense de Madrid, Campus de Somosaguas E 28223 Madrid, Spain
Neuropharmacology 54:219-25. 2008....
- Separation of the convulsions and antidepressant-like effects produced by the delta-opioid agonist SNC80 in ratsEmily M Jutkiewicz
Department of Pharmacology, University of Michigan Medical School, 1301 MSRB III, Ann Arbor, MI 48109 0632, USA
Psychopharmacology (Berl) 182:588-96. 2005..Therefore, determining how to separate the convulsive and antidepressant-like characteristics of these compounds is essential for their potential clinical use...
- The possible role of the NO-cGMP pathway in nociception: different spinal and supraspinal action of enzyme blockers on rat dorsal horn neuronesUlrich Hoheisel
Institut fur Pharmakologie und Toxikologie, Charite, Humboldt Universitat, Berlin, Germany
Pain 117:358-67. 2005..The results show that at the spinal level, a lack of cGMP and NO has an excitatory action on dorsal horn neurones, whereas supraspinally an elevated level of cGMP is excitatory...
- Dopamine and adenosine receptor interaction as basis for the treatment of Parkinson's diseaseNicola Simola
Department of Toxicology and Centre of Excellence for Neurobiology of Dependence, University of Cagliari, 09124 Cagliari, Italy
J Neurol Sci 248:48-52. 2006..The prospective of providing additional antitremor benefits considerably enhances the therapeutic potential of A(2A) antagonists...
- Effects and mechanisms of supraspinal administration of rat/mouse hemokinin-1, a mammalian tachykinin peptide, on nociception in miceCai Yun Fu
Department of Biochemistry and Molecular Biology, School of Life Science, Lanzhou University, 222 Tian Shui South Road, Lanzhou 730000, People s Republic of China
Brain Res 1056:51-8. 2005..c.v. administration of r/m HK-1...
- Limited brain diffusion of the glucocorticoid receptor agonist RU28362 following i.c.v. administration: implications for i.c.v. drug delivery and glucocorticoid negative feedback in the hypothalamic-pituitary-adrenal axisA B Francis
Campus Box 345, University of Colorado at Boulder, Boulder, CO 80309, USA
Neuroscience 141:1503-15. 2006....
- Pronociceptive role of peripheral and spinal 5-HT7 receptors in the formalin testHéctor I Rocha-González
Departamento de Farmacobiologia, Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional, Calzada de los Tenorios 235, Colonia Granjas Coapa, 14330 Mexico, D F, Mexico
Pain 117:182-92. 2005..Data suggest that 5-HT7, but not 5-HT1A, receptors play a pronociceptive role in peripheral and spinal sites in the rat formalin test...
- ABT-594 (a nicotinic acetylcholine agonist): anti-allodynia in a rat chemotherapy-induced pain modelJames J Lynch
Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Department R4N5, Bldg AP9A LL, 100 Abbott Park Road, Abbott Park, IL 60064 6115, USA
Eur J Pharmacol 509:43-8. 2005....
- Large-amplitude 5-HT1A receptor activation: a new mechanism of profound, central analgesiaF C Colpaert
Centre de Recherche Pierre Fabre, 17, avenue Jean Moulin, 81106 Castres Cedex, France
Neuropharmacology 43:945-58. 2002....
- Noradrenaline transporter blockers raise extracellular dopamine in medial prefrontal but not parietal and occipital cortex: differences with mianserin and clozapineV Valentini
Department of Toxicology and Centre of Excellence Neurobiology of Addiction, University of Cagliari, Cagliari, Italy
J Neurochem 88:917-27. 2004..This process, although extensive in the PFCX, appears insignificant in the ParCX and OccCX, probably as a result of the higher ratio of NA to DA resulting in exclusion of DA from NA transporter...
- Novel mechanism of enhanced nociception in a model of AIDS therapy-induced painful peripheral neuropathy in the ratElizabeth K Joseph
Department of Medicine, Division of Neuroscience and Biomedical Sciences Program, and UCSF NIH Pain Center, University of California, San Francisco, CA 94143 0440, USA
Pain 107:147-58. 2004..This study provides evidence for a novel, calcium-dependent, mechanism for neuropathic pain in a model of AIDS therapy-induced painful peripheral neuropathy...
- Effects on cocaine and food self-administration of (+)-HA-966, a partial agonist at the glycine/NMDA modulatory site, in ratsLuigi Cervo
Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy
Psychopharmacology (Berl) 173:124-31. 2004..Since this effect was observed studying only one dose of cocaine and considering the characteristic bell-shaped curve generated by cocaine in self-administration studies under FR schedules, the precise nature of the effect is not clear...
- Prolonged nicotine dependence associated with extended access to nicotine self-administration in ratsNeil E Paterson
Department of Neuropharmacology CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Psychopharmacology (Berl) 173:64-72. 2004..Most nicotine self-administration (NSA) studies in rats are performed under limited-access conditions. Few studies have examined the relationship between nicotine dependence and NSA...
- Further evidence for the mediation of both subtypes of dopamine D1/D2 receptors and cerebral neuropeptide Y (NPY) in amphetamine-induced appetite suppressionDong Yih Kuo
Department of Physiology, Chung Shan Medical University, Taichung City, Taiwan 402, ROC
Behav Brain Res 147:149-55. 2003..Taken together, the present results confirmed that both subtypes of D1 and D2 receptors and cerebral NPY were involved in the anorectic action of AMPH...
- A peripheral cannabinoid mechanism suppresses spinal fos protein expression and pain behavior in a rat model of inflammationA G Nackley
Neuroscience and Behavior Program, Department of Psychology, The University of Georgia, Athens, GA 30602 3013, USA
Neuroscience 117:659-70. 2003....
- Pharmacological characterisation of a rat model of incisional painGarth T Whiteside
Neuropharmacology, Purdue Pharma LP, 6 Cedar Brook Drive, Cranbury, NJ 08512, USA
Br J Pharmacol 141:85-91. 2004....
- Reversal of phencyclidine-induced dopaminergic dysregulation by N-methyl-D-aspartate receptor/glycine-site agonistsDaniel C Javitt
Nathan Kline Institute for Psychiatric Research, NYU School of Medicine, Orangeburg, NY, USA
Neuropsychopharmacology 29:300-7. 2004..These findings demonstrate effective doses of glycine for use in animal models of schizophrenia, and support recent clinical studies showing the effectiveness of NMDA agonists in the treatment of persistent symptoms of schizophrenia...
- Intraseptal infusion of oxotremorine impairs memory in a delayed-non-match-to-sample radial maze taskJ G Bunce
Department of Psychology, University of Connecticut, Storrs, CT 06269, USA
Neuroscience 121:259-67. 2003....
- Effects of cocaine in rats exposed to heroinFrancesco Leri
Department of Psychology, University of Guelph, Canada
Neuropsychopharmacology 28:2102-16. 2003..In response to cocaine, however, DA activity in the Acb was significantly lower in rats withdrawn from the highest dose of heroin...
- Inhibition of [18F]FP-TZTP binding by loading doses of muscarinic agonists P-TZTP or FP-TZTP in vivo is not due to agonist-induced reduction in cerebral blood flowKazuaki Shimoji
Positron Emission Tomography Department, Clinical Center, NIMH, National Institutes of Health, Bethesda, Maryland 20892, USA
Synapse 50:151-63. 2003..The methods employed here may also be of interest to evaluate physiological effects of blocking agents utilized to validate other radiopharmaceuticals...
- Peripheral and central sites of action for A-85380 in the spinal nerve ligation model of neuropathic painLynne E Rueter
Neurological Research, D4N5 AP9A, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 6115, USA
Pain 103:269-76. 2003..Together these data further support the idea that different mechanisms underlie different pain states and suggest that the effects of NNR agonists in neuropathic pain may be due in part to peripheral actions of the compounds...
- The mGluR5 antagonist MPEP decreased nicotine self-administration in rats and miceNeil E Paterson
Department of Neuropharmacology, CVN 7, The Scripps Research Institute, La Jolla, CA 92037, USA
Psychopharmacology (Berl) 167:257-64. 2003..Metabotropic glutamate receptors 5 (mGluR5) are found in the nucleus accumbens and may play a role in modulating the post-synaptic response to both glutamate and dopamine...
- The effects of endogenous interleukin-1 bioactivity on locus coeruleus neurons in response to bacterial and viral substancesMark K Borsody
Department of Psychiatry and Behavioral Sciences, Emory University Medical School, Emory West Campus, 1256 Briarcliff Road, N E, Atlanta, GA 30306, USA
Brain Res 1007:39-56. 2004..In contrast, poly(I)/(C) increased the activity of LC neurons but this did not critically involve IL-1 receptors in the LC...
- Evidence that CB-1 and CB-2 cannabinoid receptors mediate antinociception in neuropathic pain in the ratDavid A Scott
The Department of Pharmacology, University of Melbourne, Melbourne, VIC 3010, Australia
Pain 109:124-31. 2004..005). These results suggest a role for CB-2 receptor-mediated antinociception in both acute and neuropathic pain in addition to centrally located CB-1 mechanisms...
- Roles of opioid receptor subtypes on the antinociceptive effect of intrathecal sildenafil in the formalin test of ratsMyung Ha Yoon
Department of Anesthesiology and Pain Medicine, Chonnam National University, Medical School, Gwangju, Republic of Korea
Neurosci Lett 441:125-8. 2008..Both mu and delta opioid receptors are involved. However, it seems that kappa opioid receptors play in the effect of sildenafil...
- Blockade of peripheral 5HT3 receptor attenuates the formalin-induced nocifensive behavior in persistent temporomandibular joint inflammation of ratKeiichiro Okamoto
Department of Anatomy and Neurobiology, Wakayama Medical University, Kimiidera 811 1, Wakayama City 640 0012, Japan
Neurosci Lett 367:259-63. 2004....
- Fluoxetine administration potentiates the effect of olanzapine on locus coeruleus neuronal activityMatthew A Seager
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
Biol Psychiatry 55:1103-9. 2004..g., fluoxetine) have shown great promise in the treatment of these treatment-resistant patients. As of yet, the precise neural mechanisms responsible for the beneficial clinical effect of these combinations are not completely understood...
- Teneurin proteins possess a carboxy terminal sequence with neuromodulatory activityLiqun Wang
Department of Zoology, University of Toronto, 25 Harbord Street, Toronto, Canada M5S 3G5
Brain Res Mol Brain Res 133:253-65. 2005..These data indicate that TCAP may possess functions that are independent of the teneurin proprotein and together, the teneurins and TCAP, may represent a novel system to regulate neuronal function and emotionality...
- Behavioural effects of the novel AMPA/GluR5 selective receptor antagonist NS1209 after systemic administration in animal models of experimental painGordon Blackburn-Munro
Department of Pharmacology, Neurosearch A S, Pederstrupvej 93, DK 2750 Ballerup, Denmark
Neuropharmacology 47:351-62. 2004..Thus, systemic administration of NS1209 at non-ataxic doses has marked analgesic actions comparable to those of morphine in a range of animal models of experimental pain...
- Continuous perfusion with morphine of the orbitofrontal cortex reduces allodynia and hyperalgesia in a rat model for mononeuropathyHassen A Al Amin
Department of Psychiatry, Faculty of Medicine, American University of Beirut, Beirut, Lebanon
Neurosci Lett 364:27-31. 2004..The observed results support the idea that this area is a component of a flexible cerebral network involved in pain processing and perception...
- NPY mediates the feeding elicited by muscimol injections into the nucleus accumbens shellThomas R Stratford
Laboratory of Integrative Neuroscience and Department of Psychology m c 285, University of Illinois at Chicago, 1007 W Harrison Street, Chicago, IL 60607, USA
Neuroreport 15:2673-6. 2004..Intra-AcbSh muscimol elicited a large increase in food intake which was potently suppressed by blocking either central Y1 or Y5 receptors. Our results suggest that the AcbSh influences food intake, in part, through the release of NPY...
- MGlu5 antagonism impairs exploration and memory of spatial and non-spatial stimuli in ratsGert R J Christoffersen
Department of Biology, August Krogh Building, University of Copenhagen, DK 2100 Copenhagen, Denmark
Behav Brain Res 191:235-45. 2008..However, the fact that prelimbic administration of MPEP inhibited retention without reducing exploration shows that memory formation was also impacted directly by prelimbic mGlu5 in both spatial and non-spatial learning...
- Increased nociceptive response in mice lacking the adenosine A1 receptorWei ping Wu
Department of Neurotec, Division of Clinical Neurophysiology, Karolinska Institutet, Karolinska University Hospital Huddinge, S 141 86 Stockholm, Sweden
Pain 113:395-404. 2005..A1 receptors also contribute to the antinociceptive effect of spinal morphine. Selective A1 receptor agonists may be tested clinically as analgesics, particularly under conditions of neuropathic pain...
- Antidepressant-like effects of uridine and omega-3 fatty acids are potentiated by combined treatment in ratsWilliam A Carlezon
Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts, USA
Biol Psychiatry 57:343-50. 2005..We also examined the effects of omega-3 fatty acids (OMG), which increase membrane fluidity and reportedly have antidepressant effects in humans, alone and in combination with uridine...
- Behavioral effects of intracerebroventricular microinfusion of agmatine in adult ratsPing Liu
Department of Anatomy and Structural Biology, School of Medical Sciences, University of Otago, Dunedin, New Zealand
Behav Neurosci 122:557-69. 2008..These results suggest that the behavioral effects of agmatine are task- and dose-dependent, and agmatine may be an anxiolytic and memory modulator...
- [The new 2005 resuscitation guidelines of the European Resuscitation Council: comments and supplements]V Wenzel
Univ Klinik für Anaesthesie und Allgemeine Intensivmedizin, Medizinische Universitat, Anichstrasse 35, 6020, Innsbruck, Austria
Anaesthesist 55:958-66, 968-72, 974-9. 2006..b>Drug administration routes for adults and children: first choice IV, second choice intraosseous, third choice endobronchial [..
- [Comments on the 2010 guidelines on cardiopulmonary resuscitation of the European Resuscitation Council]V Wenzel
Univ Klinik für Anaesthesie und Intensivmedizin, Medizinische Universitat Innsbruck, Anichstr 35, 6020, Innsbruck, Osterreich
Anaesthesist 59:1105-23. 2010..Supraglottic airway devices are alternatives to tracheal intubation. Drug administration routes for adults and children: first choice i.v., second choice intraosseous (i.o.)...
- The inhalation of drugs: advantages and problemsJoseph L Rau
Department of Cardiopulmonary Care Sciences, Georgia State University, Atlanta, USA
Respir Care 50:367-82. 2005..Potential improvements in aerosol delivery include better standardization of function and patient use, greater reliability, and reduction of drug loss...
- Implementation of an integrated drug information system for inpatients to reduce medication errors in administering stageTun Yang Lawrence Sung
Graduate Institute of Medical Informatics, Taipei Medical University, Taipei, Taiwan
Conf Proc IEEE Eng Med Biol Soc 2008:743-6. 2008..on a computerized drug cart and could provide patients' data, drug information with drug images, drug administration routes, drug interactions, and intravenous drug compatibility information...
- Proteinuria in a placebo-controlled study of basic fibroblast growth factor for intermittent claudicationL T Cooper
Mayo Clinic and Foundation, Cardiovascular Division, Rochester, MN 55905, USA
Vasc Med 6:235-9. 2001..Future clinical trials of bFGF protein should carefully monitor renal function and consider alternative dosing schedules and drug administration routes.
- Sedation in the geriatric patientJulián López-Jiménez
Universidad Internacional de Cataluña, Espana
Med Oral 9:45-55. 2004..A description is made of the recommended psychoactive drug administration routes according to the associated pathology and of the most frequent pharmacological interactions with the ..
- [Pharmacokinetics (PK) of mAbs]Gilles Paintaud
Universite Francois Rabelais de Tours, lt lt Génétique, Immunothérapie, chimie et cancer gt gt, France
Med Sci (Paris) 25:1057-62. 2009..Complex PK models are needed to describe satisfactorily their fate in the body and their concentration-effect relationship...
- Optimising antimicrobial therapy in diabetic foot infectionsNalini Rao
Division of Infectious Disease, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15232 1381, USA
Drugs 67:195-214. 2007..Certain other organisms, such as Pseudomonas aeruginosa and Enterococcus spp., while potentially pathogenic, are often colonisers that do not require targeted therapy...
- A novel stent for percutaneous heart valve implantation: first in vitro resultsC Marchand
LPMT, ENSISA, CNRS UMR 7189, Mulhouse, France
J Biomech Eng 132:054502. 2010..Prosthesis static and dynamic regurgitation are evaluated and show values close to those obtained with other commercially available prostheses...
- Abdominal aorta anastomosis in rats and stable gastric pentadecapeptide BPC 157, prophylaxis and therapyM Hrelec
Department of Pharmacology and Pathology, Medical Faculty, University of Zagreb, Zagreb, Croatia
J Physiol Pharmacol 60:161-5. 2009....
- Post-retrieval disruption of a cocaine conditioned place preference by systemic and intrabasolateral amygdala beta2- and alpha1-adrenergic antagonistsRick E Bernardi
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97239, USA
Learn Mem 16:777-89. 2009..These systemic and site-specific injections, as well as the FOS immunohistochemical analyses, implicate the importance of specific noradrenergic signaling mechanisms within the BLA in post-retrieval plasticity...
- Specific immunotherapy in pollen allergyMichael Wallner
Christian Doppler Laboratory for Allergy Diagnosis and Therapy, Department of Molecular Biology, University of Salzburg, Hellbrunnerstralle 34, A 5020 Salzburg, Austria
Curr Opin Mol Ther 9:160-7. 2007..These new formulations, for use in the routine management of pollen allergies, should become available in the near future...
- Opioid rotation in patients with cancer: a review of the current literatureAthina Vadalouca
Pain Therapy and Palliative Care, Aretaieion University Hospital, Athens, Greece
J Opioid Manag 4:213-50. 2008..However, too much work is to be done to further individualize analgesic therapy for patients with cancer...
- Drug administration via nasogastric tubeSonya Clarke
School of Nursing and Midwifery, Queen s University, Belfast
Paediatr Nurs 20:32. 2008..Findings of the review are summarised here in relation to using the nasogastric tube to administer medication to children with the aim of informing practice and improving safety...
- Analysis of the chronic intake of and withdrawal from diazepam on emotional reactivity and sensory information processing in ratsJ De Ross
Instituto de Neurociências and Comportamento INeC, Campus USP, 14040 901, Ribeirao Preto, SP, Brazil
Prog Neuropsychopharmacol Biol Psychiatry 32:794-802. 2008..All these findings are indicative of a sensitization of the neural substrates of aversion in diazepam-withdrawn animals without concomitant changes on the processing of sensory information...
- Evaluation of transmission of Brucella abortus strain 19 in bison by intravaginal, intrauterine, and intraconjunctival inoculationSamantha R Uhrig
Department of Clinical Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
J Wildl Dis 49:522-6. 2013..abortus. The seroconversion of four of eight VI bison indicated exposure of the immune system to the agent and the need for further studies on venereal transmission in bison...
- Glossitis and tongue trauma subsequent to administration of an oral medication, using an udder infusion cannula, in a horseMark C Fuller
Department of Health Management, Atlantic Veterinary College, University of Prince Edward Island, 550 University Avenue, Charlottetown, Prince Edward Island
Can Vet J 48:845-7. 2007..The tongue appeared to have been punctured inadvertently. The horse recovered after treatment with intravenous fluid, antibiotics, and anti-inflammatory drugs. Administering oral medication by this method should be discouraged...
- Ventilatory and cardiovascular actions of centrally administered trout tachykinins in the unanesthetized troutJean Claude Le Mevel
Laboratoire de Traitement de l Information Médicale, INSERM U650, Faculte de Medecine et des Sciences de la Sante, Universite de Bretagne Occidentale, 22 avenue Camille Desmoulins, CS 93837, 29238 Brest Cedex 3, France
J Exp Biol 210:3301-10. 2007....
- Monoamine oxidase inhibition dramatically prolongs the duration of nicotine withdrawal-induced place aversionKarine Guillem
Laboratoire de Neuropsychobiologie des Désadaptations UMR CNRS 5541, Universite de Bordeaux 2, Bordeaux, France
Biol Psychiatry 63:158-63. 2008....
- Importance of cocaine- and amphetamine-regulated transcript peptide in the central nucleus of amygdala in anxiogenic responses induced by ethanol withdrawalManoj P Dandekar
Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University Campus, Nagpur, India
Neuropsychopharmacology 33:1127-36. 2008..We suggest that CART may mediate the early signs of anxiety-like behavior induced by ethanol withdrawal within the neuroanatomical framework of the CeA...
- [Criteria for delegating the safe hospital administration of drug therapy via natural route to nurses aids in hospital]Alvisa Palese
Universita Degli Studi di Udine
Assist Inferm Ric 31:228-33. 2012..To assess if and how many patients admitted to hospital could receive the drug therapy via natural route by specialized nurses aids (OSSc)...
- Botulinum neurotoxins and formalin-induced pain: central vs. peripheral effects in miceSiro Luvisetto
Istituto di Neuroscienze del CNR, Psicobiologia e Psicofarmacologia, Centro Europeo di Ricerca sul Cervello, Via del Fosso di Fiorano 64, 00143 Roma, Italy
Brain Res 1082:124-31. 2006..Such data suggest BoNTs as a useful tool in the studies aimed at the comprehension of the mechanisms of inflammatory pain...
- Hyaluronan facilitates hematopoietic recovery following ionizing irradiationSophia K Khaldoyanidi; Fiscal Year: 2010..In addition, we will test different drug administration routes including oral and subcutaneous...
- NICOTINE DEPENDENCE--TAILORING AND PREFERENCE RESEARCHNina Schneider; Fiscal Year: 2001..Several new scales will be tested: one which assesses withdrawal via anchored responding and a set of scales for testing preference with an ultimate aim of developing a tool for easily matching smokers to therapy. ..
- OPIOID DEPRESSION OF RESPIRATORY NEURONSPETER LALLEY; Fiscal Year: 2003..It will also test a new method that may alleviate opioid-induced depression of respiration without affecting analgesia, and counteract respiratory depression by overdose of opioids. ..
- Methylated Genes as Serum Biomarkers for Lung CancerMark Kris; Fiscal Year: 2008..Future studies will be required to establish this technique as a reliable diagnostic tool to guide the management of patients with lung cancer. ..
- RCT of Russian IDU Peer Network HIV Prevent InterventionCarl Latkin; Fiscal Year: 2007..abstract_text> ..
- Protective Influence of Residential Learning CommunitiesSEAN MCCABE; Fiscal Year: 2006..At each measurement point, participants will complete a set of measures that assess substance use behaviors and constructs addressed by RLCs. ..
- Bladder Regulation by Corticotropin-Releasing FactorRITA VALENTINO; Fiscal Year: 2006..These studies unite complementary expertise from laboratories in urology and basic neuroscience to increase our knowledge of the central regulation of urinary function in normal and pathological state. [unreadable] [unreadable]..
- Giant Cell Myocarditis Treatment Trial Pilot StudyCOOPER LESLIE; Fiscal Year: 2005..Abstract Not Provided ..
- Intracerebral Infusion of Radiolabeled Specific AntibodyJohn Sampson; Fiscal Year: 2006..abstract_text> ..
- Dendritic Cell Immunotherapy of Malignant GliomasJohn Sampson; Fiscal Year: 2006..abstract_text> ..
- Training Program in NeurovirologyHOWARD GENDELMAN; Fiscal Year: 2006....
- Promoter-Based Mapping of Amygdala MicrocircuitsDonald Rainnie; Fiscal Year: 2006..These experiments will advance our understanding of the primate amygdala, a necessary step for understanding the pathophysiology of and development of novel treatments for disorders of alcohol addiction and other psychiatric disorders. ..
- Gene Repair in signal Transduction after CNS InjuryPhilip Liu; Fiscal Year: 2006..abstract_text> ..
- Comorbid childhood anxiety and asthmaRenee Goodwin; Fiscal Year: 2006..That study will involve a longitudinal epidemiologic preventive intervention study aimed at reducing the risk of anxiety disorders among pediatric asthma/allergy patients. ..
- Development of CART for HIV adherence and cocaine abuseKaren Ingersoll; Fiscal Year: 2006..unreadable] [unreadable]..
- LATENCY AND REACTIVATION TUBERCULOSISYUKARI MANABE; Fiscal Year: 2006..Appropriate animal models are critical to the successful development of tuberculosis vaccines, new drugs and better diagnostic tests for tuberculosis. ..
- Treatment of Early Stage Multiple MyelomaS Rajkumar; Fiscal Year: 2006..BM angiogenesis will be studied using immunostaining (IHC) for CD34 and an in vitro human angiogenesis assay. VEGF expression will be studied using IHC and quantitative RT-PCR. ..
- A Network & Dyad HIV Prevention Intervention for Intravenous Drug UserCarl Latkin; Fiscal Year: 2007..Main outcome measures will be self-reported sex and injection risk behaviors. Self-reports will be cross-validated by urinalysis of STIs. [unreadable] [unreadable]..
- Hyperalgesia in Methadone Patients: Can it be Treated?Margaret Compton; Fiscal Year: 2007..abstract_text> ..
- Supraspinal Modulation of Neuropathic PainBradley Taylor; Fiscal Year: 2007..abstract_text> ..
- Case Management Alternatives for African American Women at High Risk for HIVHilary L Surratt; Fiscal Year: 2010....
- Phencyclidine Abuse & Psychosis: Biomedical MechanismsDaniel C Javitt; Fiscal Year: 2010....
- CD47 as a neurovascular target for stroke therapyEng H Lo; Fiscal Year: 2010..Proof-of-concept data collected here may lead to the development of CD47 as a novel neurovascular target for stroke therapy. ..
- How does Motivational Interviewing Work? Mechanisms of Action in Project CHOICESKaren Ingersoll; Fiscal Year: 2009..Once these components are identified, new, science-based interventions could be developed for a range of health-threatening behaviors for people with chronic illnesses including addictive disorders. ..
- NEUROPEPTIDERGIC INHIBITION OF SPINAL PAIN TRANSMISSIONBradley Taylor; Fiscal Year: 2008..We predict that the activity of this population of spinal neurons will be decreased by NPY administration, and increased by NPY knockdown. ..
- The Role of NF-kappaB in Chemotherapy ResistanceJames Cusack; Fiscal Year: 2009..This proposal has the potential to completely alter chemotherapy strategies based on our understanding of the role of NF-kappaB in chemotherapy resistance. ..
- Alcohol, Sleep and Brain DevelopmentIAN COLRAIN; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Oral Androgen Administration and Function in ManJOHN AMORY; Fiscal Year: 2008..Matsumoto M.D., Director, Clinical Research Unit VA-Puget Sound and Professor of Medicine, University of Washington School of Medicine will co-mentor this award. [unreadable] [unreadable]..
- Systems Biology of Angiogenesis: from Molecules to TherapyBRIAN ANNEX; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- STEM CELLS AND AGINGStewart Sell; Fiscal Year: 2008..The results of these experiments should provide critical proof for one of the most important hypothetical properties of adult stem cells. ..
- Estrogen & Progesterone Effects on Orthostatic ToleranceNINA STACHENFELD; Fiscal Year: 2010..We also expect that the data in these studies will provide a basis to study the impact of sex hormones on diseases related to compromised peripheral circulation, such as hypertension, Raynaud's phenomenon and diabetes ..
- LEVODOPA PHARMACOKINETICS AND PHARMACODYNAMICSJohn Nutt; Fiscal Year: 2008..unreadable] [unreadable]..
- Progesterone Modulation of Pulsatile GnRH SecretionCHRISTOPHER MCCARTNEY; Fiscal Year: 2007..McCartney's development into an independent patient-oriented investigator in the field of reproductive endocrinology. [unreadable] [unreadable]..
- Antibody mediated intracellular bacterial eliminationGary Winslow; Fiscal Year: 2006....
- NEURONAL ELECTROPHYSIOLOGY IN HIV DEMENTIAHOWARD GENDELMAN; Fiscal Year: 2001....
- ALTERNATIVE THERAPIES FOR MENOPAUSE: A RANDOMIZED TRIALKatherine Newton; Fiscal Year: 2004....
- Cadmium Teratogenesis to murine strains proteomicsMichael Collins; Fiscal Year: 2003..abstract_text> ..
- HIV ADHERENCE MENTORED RES. SCIENTIST DEV. AWARDKaren Ingersoll; Fiscal Year: 2003..abstract_text> ..
- Nocardia: A Novel Environmental Agent For Parkinsonism?Peter LeWitt; Fiscal Year: 2003..These outcomes will be significant because they should add to our understanding of the neurodegenerative process in PD, and could lead to improved means of diagnosis and treatment for individuals with this disorder. ..
- REGULATION OF BBB GLUT1 GLUCOSE TRANSPORTERWilliam Pardridge; Fiscal Year: 2002..These studies will provide insight into molecular mechanisms of regulation of a step crucial to the maintenance of cerebral intermediary metabolism, i.e., the continuous transport of glucose across the blood-brain barrier in vivo. ..
- PASSIVE IMMUNITY TO COCAINE USING NOVEL HUMAN ANTIBODIESAndrew Norman; Fiscal Year: 2003..These studies will form the basis for an application to the FDA for advancement of an identified human monoclonal anti-cocaine antibody to Phase II clinical trials to determine the efficacy of a passive immunotherapy of cocaine abuse. ..
- Behavioral Despair and Interleukin-1Terrence Deak; Fiscal Year: 2002..abstract_text> ..
- PILOT TRIAL OF THALAMIC STIMULATION FOR EPILEPSYRobert Fisher; Fiscal Year: 2001..A consortium of centers experienced in epilepsy research will collaborate on this project, which will move brain stimulation for epilepsy into the realm of a testable new therapy for intractable seizures. ..
- PAIN, OPIOID ANALGESIA AND BLOOD PRESSURE CONTROLBradley Taylor; Fiscal Year: 2002..The results of these studies will facilitate our understanding of the mechanisms that contribute to chronic pain in the hypertensive patient. ..
- High-Density ERP mapping & FMRIDaniel Javitt; Fiscal Year: 2002..The equipment will also permit monitoring of background EEG during both human and animal studies. Software is requested for state-of-the-art ERP dipole mapping and ERP/MRI co-registration. ..
- BIODEGRADABLE HYDROPHILIC POLYACETALSMIKHAIL PAPISOV; Fiscal Year: 2001..abstract_text> ..
- Neurobiology of Orexin/Hypocretin-Induced ArousalCRAIG BERRIDGE; Fiscal Year: 2004..These studies will provide a better understanding of the neurobiology of orexin, the neurobiology of sleep and waking, and the potential role of orexin in narcolepsy and other disorders of arousal. ..
- BIOGENIC AMINE SYSTEMS, CRF, AND STRESSRITA VALENTINO; Fiscal Year: 2005..Like the previous K02 award, the K05 award will promote future career development by providing stable salary support and flexibility to enhance technical skills and conceptual bases and promoting leadership. ..
- Murine strain sensitivity to cadmium teratogenesisMichael Collins; Fiscal Year: 2005..An additive oligogenic model involving nine genes for the induction of the forelimb defect has been proposed. ..
- Vascular Protection in Acute Ischemic StrokeSusan Fagan; Fiscal Year: 2005..Collectively, the successful completion of the research summarized in this proposal can be expected to contribute to the development of methods to make reperfusion safer, and therefore more accessible, to human stroke patients. ..
- Antisense imaging of brain gene expression in vivoWilliam Pardridge; Fiscal Year: 2005..This technology could be extended to humans and to other organs. At present, there is no parallel technology that enables the non-invasive in vivo imaging of "any gene in any person," which is the goal of this work. ..
- Genetic Risk Factors for Portopulmonary HypertensionSteven Kawut; Fiscal Year: 2005..In addition, this pilot study could suggest targeted preventative or therapeutic modalities, leading to clinical trials for an "orphan" disease routinely excluded from other research programs and trials of therapy. ..
- BRAIN/PELVIC VISCERA INTERACTIONS IN PSYCHIATRIC DISEASERITA VALENTINO; Fiscal Year: 2001....
- Pharmacotherapy for Minor DepressionRobert Howland; Fiscal Year: 2004..The results of this study will have profound public health implications by improving our understanding of the efficacy of SJW and standard antidepressants for the treatment of MinorD. ..
- PROTEASE INHIBITOR RELATED ATHEROSCLEROSIS IN HIVAndrew Carr; Fiscal Year: 2005....
- Nucleus Accumbens-Mediated Feeding: Output PathwaysThomas R Stratford; Fiscal Year: 2010....
- Localized modulation of RPE P-gp/MRP activity for back-of-the-eye drug deliverySoumyajit Majumdar; Fiscal Year: 2008..unreadable] [unreadable]..
- IRON REGULATION & VIRULENCE--MYCOBACTERIUM TUBERCULOSISYUKARI MANABE; Fiscal Year: 2003..Elucidation of this iron-dependent IdeR regulon may lead to the identification of virulence determinants, and novel antigens for vaccines and therapeutics. ..
- NITROXIDERGIC CEREBROVASCULAR TONE DURING ANESTHESIAShailendra Joshi; Fiscal Year: 2005..abstract_text> ..
- SYSTEMIC LYMPH NODE SPECIFIC AGENTSMIKHAIL PAPISOV; Fiscal Year: 2003..If successful, this project will result in the development of a new class of preparations and a new strategy for prophylactic and early post-exposure treatment of bacterial diseases of Category A. ..
- SEX HORMONES AND BODY FLUID REGULATIONNINA STACHENFELD; Fiscal Year: 2003....
- TISSUE-SPECIFIC EFFECTS OF PROGESTINSKATHRYN HORWITZ; Fiscal Year: 2003..NT-B, and ligand-regulated transcription by full-length PR. The proposed studies address the presently unknown functions of the two PR N-termini. ..
- BRAIN CELL APOPTOSIS AFTER INTRACEREBRAL HEMORRHAGEENG LO; Fiscal Year: 2003..Results may be used to improve the clinical management and treatment of intracerebral hemorrhage. ..
- Oleylethanolamide derivatives as anti-obesity agentsDaniele Piomelli; Fiscal Year: 2005....
- NEUROBEHAVIORAL MECHANISMS OF DRUG ADDICTIONSTANLEY GLICK; Fiscal Year: 2001..This research may result in novel treatments for addictive disorders in humans. ..
- A Decision Support Tool for Adult Sickle Cell Emergency Department PatientsPaula Tanabe; Fiscal Year: 2010..This knowledge will position the candidate to launch a research career as an investigator who will conduct projects aimed at scientifically evaluating mechanisms to improve the care of persons with SCD in the ED setting. ..
- Characterization of a novel brain cannabinoid ligandDaniele Piomelli; Fiscal Year: 2010..The objective of our research is to understand how these transmitters are produced and eliminated, and discover innovative medicines that target these processes. ..
- PHARMACOLOGY & NEUROSCIENCE TRAINING IN DRUG ABUSESTANLEY GLICK; Fiscal Year: 2008..All aspects of the program are administered by the director and an executive committee of administrative and training faculty. ..
- NABTC Member Intitution Grant (UCSF Project Leader)Susan Chang; Fiscal Year: 2008..The overall goal of this program is to more effectively treat patients with primary brain tumors, especially malignant glioma, with the purpose of increasing the duration and quality of survival. ..
- CONTROL OF ENDOCANNABINOID RELEASE IN VIVODaniele Piomelli; Fiscal Year: 2003..Moreover, by uncovering the neurochemical interactions between cocaine and the endogenous cannabinoids, our studies will contribute to the general understanding of substance abuse and neuropsychiatric disorders. ..
- Mechanisms of Vascular Injury in the preterm lungSuhas Kallapur; Fiscal Year: 2006..The experimental design in this proposal incorporates challenging but, particularly in this environment achievable goals that will provide important knowledge in the pathogenesis of bronchopulmonary dysplasia. ..
- RESPONSIVE POLYMER ENGINEERED PROTEIN CONJUGATESAllan Hoffman; Fiscal Year: 2001..This action should increase the efficacies of gene, antisense oligonucleotide, and cancer therapies. ..
- DIENCEPHALIC MECHANISMS OF DRUG ABUSESTANLEY GLICK; Fiscal Year: 2008..The work proposed here may ultimately result in new kinds of treatments for drug abuse. ..