drug administration routes

Summary

Summary: The various ways of administering a drug or other chemical to a site in a patient or animal from where the chemical is absorbed into the blood and delivered to the target tissue.

Top Publications

  1. ncbi Neurosteroid allopregnanolone mediates anxiolytic effect of etifoxine in rats
    Rajesh R Ugale
    Pharmacology Division, Shrimati Kishoritai Bhoyar College of Pharmacy, New Kamptee 441 002, Nagpur, Maharashtra, India
    Brain Res 1184:193-201. 2007
  2. pmc Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease
    Leah R Hanson
    Alzheimer s Research Center at Regions Hospital, HealthPartners Research Foundation, 640 Jackson Street, St, Paul, MN 55101, USA
    BMC Neurosci 9:S5. 2008
  3. ncbi Delivery of NGF to the brain: intranasal versus ocular administration in anti-NGF transgenic mice
    Simona Capsoni
    Lay Line Genomics S p A, Rome, Italy
    J Alzheimers Dis 16:371-88. 2009
  4. ncbi Size-dependent disposition of nanoparticles and microparticles following subconjunctival administration
    Aniruddha C Amrite
    Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE 68198 6025, USA
    J Pharm Pharmacol 57:1555-63. 2005
  5. ncbi A 10 year retrospective audit of long-term apomorphine use in Parkinson's disease
    Hilary L Tyne
    The University of Liverpool, UK
    J Neurol 251:1370-4. 2004
  6. ncbi The acceptability of different routes of administration of analgesia for breakthrough pain
    G Walker
    Palliative Care Cancer Unit, Nottingham City Hospital NHS Trust, Nottingham, UK
    Palliat Med 17:219-21. 2003
  7. ncbi Long-term 24-hour duodenal infusion of levodopa: outcome and dose requirements
    Dag Nyholm
    Department of Neuroscience, Neurology, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
    Neurology 65:1506-7. 2005
  8. ncbi Continuous apomorphine infusion and neuropsychiatric disorders: a controlled study in patients with advanced Parkinson's disease
    A E Di Rosa
    Department of Neuroscience, University of Messina, Via Consolare Valeria, Messina, Italy
    Neurol Sci 24:174-5. 2003
  9. ncbi Opioid delivery in the treatment of cancer breakthrough pain: a review of routes of administration
    Bruce Nicholson
    Division of Pain Medicine, Pain Specialists of Greater Lehigh Valley, Pennsylvania, USA
    J Opioid Manag 7:69-79. 2011
  10. ncbi Development of a non invasive NGF-based therapy for Alzheimer's disease
    Sonia Covaceuszach
    Lay Line Genomics S p A, Rome, Italy
    Curr Alzheimer Res 6:158-70. 2009

Detail Information

Publications244 found, 100 shown here

  1. ncbi Neurosteroid allopregnanolone mediates anxiolytic effect of etifoxine in rats
    Rajesh R Ugale
    Pharmacology Division, Shrimati Kishoritai Bhoyar College of Pharmacy, New Kamptee 441 002, Nagpur, Maharashtra, India
    Brain Res 1184:193-201. 2007
    ..Thus, our results provide behavioral evidence for the role of neurosteroids like ALLO in the anti-anxiety effect of etifoxine...
  2. pmc Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease
    Leah R Hanson
    Alzheimer s Research Center at Regions Hospital, HealthPartners Research Foundation, 640 Jackson Street, St, Paul, MN 55101, USA
    BMC Neurosci 9:S5. 2008
    ..This new method of delivery can revolutionize the treatment of Alzheimer's disease, stroke, and other brain disorders...
  3. ncbi Delivery of NGF to the brain: intranasal versus ocular administration in anti-NGF transgenic mice
    Simona Capsoni
    Lay Line Genomics S p A, Rome, Italy
    J Alzheimers Dis 16:371-88. 2009
    ..The ocular administration of hNGF-61 showed a more limited efficacy, even at higher doses. Thus, NGF nasal drops represent a viable and effective option to successfully deliver therapeutic NGF to the brain in a non-invasive manner...
  4. ncbi Size-dependent disposition of nanoparticles and microparticles following subconjunctival administration
    Aniruddha C Amrite
    Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE 68198 6025, USA
    J Pharm Pharmacol 57:1555-63. 2005
    ..Periocular administration of particulate systems of this size would likely be useful as sustained drug delivery systems...
  5. ncbi A 10 year retrospective audit of long-term apomorphine use in Parkinson's disease
    Hilary L Tyne
    The University of Liverpool, UK
    J Neurol 251:1370-4. 2004
    ..We have examined our experience of apomorphine over the last 10 years, to assess indications, pattern of use, efficacy, and side effect profile...
  6. ncbi The acceptability of different routes of administration of analgesia for breakthrough pain
    G Walker
    Palliative Care Cancer Unit, Nottingham City Hospital NHS Trust, Nottingham, UK
    Palliat Med 17:219-21. 2003
  7. ncbi Long-term 24-hour duodenal infusion of levodopa: outcome and dose requirements
    Dag Nyholm
    Department of Neuroscience, Neurology, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
    Neurology 65:1506-7. 2005
  8. ncbi Continuous apomorphine infusion and neuropsychiatric disorders: a controlled study in patients with advanced Parkinson's disease
    A E Di Rosa
    Department of Neuroscience, University of Messina, Via Consolare Valeria, Messina, Italy
    Neurol Sci 24:174-5. 2003
    ..The neuropsychiatric assessment did not change in both groups compared with baseline, except for a significant improvement of mood in the apomorphine group...
  9. ncbi Opioid delivery in the treatment of cancer breakthrough pain: a review of routes of administration
    Bruce Nicholson
    Division of Pain Medicine, Pain Specialists of Greater Lehigh Valley, Pennsylvania, USA
    J Opioid Manag 7:69-79. 2011
    ..The purpose of this review is to provide an overview of the different routes of opioid administration used in the treatment of cancer BTP and briefly discuss the characteristics of different delivery systems...
  10. ncbi Development of a non invasive NGF-based therapy for Alzheimer's disease
    Sonia Covaceuszach
    Lay Line Genomics S p A, Rome, Italy
    Curr Alzheimer Res 6:158-70. 2009
    ..The development of hNGF-61 towards clinical applications in AD patients is under way...
  11. pmc Immunization by a bacterial aerosol
    Lucila Garcia-Contreras
    University of North Carolina, Chapel Hill, NC 27599 7360, USA
    Proc Natl Acad Sci U S A 105:4656-60. 2008
    ....
  12. pmc Methadone antinociception is dependent on peripheral opioid receptors
    Li He
    Ernest Gallo Clinic and Research Center and the Department of Neurology, University of California, San Francisco, Emeryville, CA 94608, USA
    J Pain 10:369-79. 2009
    ....
  13. ncbi Prime-boost vaccination using recombinant Mycobacterium bovis BCG and recombinant vaccinia virus DIs harboring HIV-1 CRF01_AE gag in mice: influence of immunization routes
    Duanthanorm Promkhatkaew
    Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand
    Southeast Asian J Trop Med Public Health 40:273-81. 2009
    ..d. could be used to elicit prolonged CTL responses as well as memory T-cells in mice, which might be more practical than using i.v. route...
  14. ncbi Intra-amniotic endotoxin increases pulmonary surfactant proteins and induces SP-B processing in fetal sheep
    C J Bachurski
    Division of Pulmonary Biology, Children s Hospital Research Foundation, Cincinnati, Ohio 45229, USA
    Am J Physiol Lung Cell Mol Physiol 280:L279-85. 2001
    ..IA endotoxin caused rapid and sustained increases in SP mRNAs that preceded the increase in alveolar saturated phosphatidylcholine processing of SP-B and improved lung compliance in prematurely delivered lambs...
  15. pmc Off-label use of medicines in children: can available evidence avoid useless paediatric trials? The case of proton pump inhibitors for the treatment of gastroesophageal reflux disease
    Giovanni Tafuri
    Utrecht Institute for Pharmaceutical Sciences, Utrecht University, P O Box 80 082, 3508 TB, Utrecht, The Netherlands
    Eur J Clin Pharmacol 65:209-16. 2009
    ..In some cases of drug therapy, the available evidence might be sufficient to extend the indications to children without further clinical studies...
  16. ncbi Central cyclooxygenase inhibitors reduced IL-1beta-induced hyperalgesia in temporomandibular joint of freely moving rats
    Dong K Ahn
    Department of Oral Physiology, School of Dentistry, Kyungpook National University, 188 1 Sam Deok 2 ga, Chung gu, Daegu 700 412, South Korea
    Pain 117:204-13. 2005
    ..It is concluded that central acting of COX-3 inhibitors may be of therapeutic value in the treatment of inflammatory pain in TMJ...
  17. ncbi The role of methadone in cancer pain treatment--a review
    W Leppert
    Department of Palliative Medicine, Poznan University of Medical Sciences, Poznan, Poland
    Int J Clin Pract 63:1095-109. 2009
    ..Methadone is an opioid analgesic of step 3 of the World Health Organization (WHO) analgesic ladder...
  18. ncbi Pharmacokinetics of intraocular drug delivery by periocular injections using ocular fluorophotometry
    Deepta Ghate
    Emory University Eye Center, Atlanta, Georgia 30322, USA
    Invest Ophthalmol Vis Sci 48:2230-7. 2007
    ..To evaluate the pharmacokinetics of the periocular injections: posterior subtenon (PST), retrobulbar (RB), and subconjunctival (SC) injection...
  19. ncbi Enhanced brain targeting efficiency of intranasally administered plasmid DNA: an alternative route for brain gene therapy
    In Kwon Han
    MyGene Bioscience Institute, Kangnam Gu, Seoul, South Korea
    J Mol Med (Berl) 85:75-83. 2007
    ....
  20. ncbi Use of colistin in the treatment of multiple-drug-resistant gram-negative infections
    David Berlana
    Pharmacy Service, Hospital Universitari de Bellvitge, Barcelona, Spain
    Am J Health Syst Pharm 62:39-47. 2005
    ..The use of colistin for the treatment of infections caused by multiple-drug-resistant (MDR) gram-negative microorganisms was studied...
  21. pmc Oral versus IV treatment for catheter-related bloodstream infections
    Burke A Cunha
    Emerg Infect Dis 13:1800-1; author reply 1801. 2007
  22. ncbi Urocortin 2 increases c-Fos expression in topographically organized subpopulations of serotonergic neurons in the rat dorsal raphe nucleus
    Daniel R Staub
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK
    Brain Res 1044:176-89. 2005
    ....
  23. ncbi Effects of central leptin infusion on the reward-potentiating effect of D-amphetamine
    Joy Hao
    Department of Pharmacology, New York University School of Medicine, New York, NY 10016, USA
    Brain Res 1087:123-33. 2006
    ..Together, results of this study support the importance of weight loss, but not leptin, in the enhancement of drug reward sensitivity...
  24. ncbi Analgesic effects of the selective group II (mGlu2/3) metabotropic glutamate receptor agonists LY379268 and LY389795 in persistent and inflammatory pain models after acute and repeated dosing
    Carrie K Jones
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Neuropharmacology 49:206-18. 2005
    ..The present findings indicate that group II (mGluR2/3) metabotropic glutamate receptors may be involved in the mechanisms of hyperalgesia and allodynia, however tolerance rapidly develops to these effects...
  25. ncbi Neuroprotection and functional recovery conferred by administration of kappa- and delta 1-opioid agonists in a rat model of global ischemia
    Charlaine Charron
    University of Ottawa, School of Psychology, Ottawa, ON, Canada K1N 9A9
    Physiol Behav 93:502-11. 2008
    ..Similar to U50,488H, DPDPE had no significant impact on locomotor activity. These findings support a role for kappa- and delta-opioid receptors in attenuation of ischemia-induced hippocampal damage and cognitive impairments...
  26. ncbi 18-MC acts in the medial habenula and interpeduncular nucleus to attenuate dopamine sensitization to morphine in the nucleus accumbens
    Olga D Taraschenko
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
    Synapse 61:547-60. 2007
    ..The results suggest that 18-MC acts in the habenulo-interpeduncular pathway to modulate the effects of repeated morphine in the dopaminergic mesolimbic system...
  27. ncbi Spinal and local peripheral antiallodynic activity of Ro64-6198 in neuropathic pain in the rat
    Ilona Obara
    Department of Molecular Neuropharmacology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343 Krakow, Poland
    Pain 116:17-25. 2005
    ..Therefore, besides spinal, also peripheral ORL1 receptors may be targeted by drugs designed for the long-term treatment of chronic pain...
  28. ncbi Antiallodynic effects of NMDA glycine(B) antagonists in neuropathic pain: possible peripheral mechanisms
    Thomas Christoph
    Department of Pharmacology, Grünenthal GmbH R and D, Zieglerstr 6, 52078 Aachen, Germany
    Brain Res 1048:218-27. 2005
    ..Thus, peripheral NMDA receptors may substantially contribute to the efficacy of NMDA antagonists in neuropathic pain...
  29. ncbi Modulation of NMDA receptors by intrathecal administration of the sensory neuron-specific receptor agonist BAM8-22
    Tingjun Chen
    College of Life Sciences and Provincial Key Laboratory of Developmental Biology Neuroscience, Fujian Normal University Fuzhou, Fujian 350108, People s Republic of China
    Neuropharmacology 54:796-803. 2008
    ..Taken together, these data suggest that the activation of SNSR induces spinal analgesia by suppressing NMDA receptor-mediated activation of spinal dorsal horn neurons and an increase in NOS activity...
  30. ncbi Inhibition by spinal mu- and delta-opioid agonists of afferent-evoked substance P release
    Ichiro Kondo
    Department of Anesthesiology, University of California San Diego, La Jolla, California 92093, USA
    J Neurosci 25:3651-60. 2005
    ..All effects were reversed by naloxone. These results indicate that lumbar opiates inhibit noxious stimuli-induced neurotransmitter release from primary afferents at doses that are confirmed behaviorally as analgesic...
  31. pmc U-69593, a kappa opioid receptor agonist, decreases cocaine-induced behavioral sensitization in female rats
    Anabel Puig-Ramos
    Department of Physiology, University of Puerto Rico, School of Medicine, San Juan, Puerto Rico
    Behav Neurosci 122:151-60. 2008
    ..This decrease in cocaine-induced hyperlocomotion persisted after 1 week of cocaine withdrawal. These data indicate that the KOPr system participates in estradiol modulation of cocaine-induced behavioral sensitization in the female rat...
  32. ncbi Rats maintained chronically on buprenorphine show reduced heroin and cocaine seeking in tests of extinction and drug-induced reinstatement
    Robert E Sorge
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, QC, Canada
    Neuropsychopharmacology 30:1681-92. 2005
    ....
  33. ncbi Systemic administration of a dopamine, but not a serotonin or norepinephrine, transporter inhibitor reinstates cocaine seeking in the rat
    Heath D Schmidt
    Laboratory of Neuropsychopharmacology, Department of Pharmacology, L 603, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Behav Brain Res 175:189-94. 2006
    ..These results suggest that increases in extracellular concentrations of dopamine, specifically in the nucleus accumbens shell, are primarily responsible for promoting cocaine priming-induced reinstatement of drug seeking in rats...
  34. pmc Antihyperalgesic effects of loperamide in a model of rat neuropathic pain are mediated by peripheral delta-opioid receptors
    Katsumi Shinoda
    Pharmaceutical Research Center, Kyowa Hakko Kogyo Co, Ltd, 1188 Shimotogari, Nagaizumi cho, Sunto gun, Shizuoka ken 411 8731, Japan
    Neurosci Lett 411:143-6. 2007
    ....
  35. ncbi Roles of peripheral mitogen-activated protein kinases in melittin-induced nociception and hyperalgesia
    J Hao
    Institute for Biomedical Sciences of Pain and Institute for Functional Brain Disorders, Tangdu Hospital, Fourth Military Medical University, 1 Xinsi Road, Baqiao District, Xi an 710038, PR China
    Neuroscience 152:1067-75. 2008
    ..However, they are not likely to be involved in the processing of melittin-induced primary mechanical hyperalgesia, implicating a mechanistic separation between mechanical and thermal hyperalgesia in the periphery...
  36. ncbi Cataleptic activity of the denatured venom of the social wasp Agelaia vicina (Hymenoptera, Vespidae) in Rattus norvegicus (Rodentia, Muridae)
    Luciana de Oliveira
    Neurobiology and Venoms Laboratory, Biology Department of the Faculty of Philosophy, Sciences and Literature of Ribeirão Preto, University of Sao Paulo, Ribeirao Preto SP, Brazil
    Prog Neuropsychopharmacol Biol Psychiatry 30:198-203. 2006
    ..However, the association of haloperidol and denatured venom was reverted by theophylline but not by ketamine. These findings suggest that A. vicina venom may affect neural substrates involved with catalepsy in the central nervous system...
  37. ncbi DAMGO and 6beta-glycine substituted 14-O-methyloxymorphone but not morphine show peripheral, preemptive antinociception after systemic administration in a mouse visceral pain model and high intrinsic efficacy in the isolated rat vas deferens
    Mahmoud Al-Khrasani
    Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary
    Brain Res Bull 74:369-75. 2007
    ..Our findings support the role of peripheral MOR in the pathology of pain states involving sensitization of peripheral nociceptors...
  38. pmc Buprenorphine reduces alcohol drinking through activation of the nociceptin/orphanin FQ-NOP receptor system
    Roberto Ciccocioppo
    Department of Experimental Medicine and Public Health, University of Camerino, Camerino, Italy
    Biol Psychiatry 61:4-12. 2007
    ..Here we evaluated whether buprenorphine, a partial agonist at micro-opioid and NOP receptors, would reduce ethanol consumption in msP rats via activation of NOP receptors...
  39. ncbi Effects of rat/mouse hemokinin-1, a mammalian tachykinin peptide, on the antinociceptive activity of pethidine administered at the peripheral and supraspinal level
    Cai Yun Fu
    Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, Lanzhou University, 222 Tian Shui South Road, Lanzhou 730000, People s Republic of China
    Behav Brain Res 184:39-46. 2007
    ..Our results may pave the way for a new strategy for the control of pain and may provide a clinical strategy to enable selection of either opioid as a priority...
  40. ncbi The acute and chronic administration of (+/-)-8-hydroxy-2-(Di-n-propylamino)tetralin significantly alters the activity of spontaneously active midbrain dopamine neurons in rats: an in vivo electrophysiological study
    Kazuhiko Nakamura
    Department of Psychiatry, Hamamatsu University School of Medicine 1 20 1, Handayama, Hamamatsu, 431 3192, Shizuoka, Japan
    Synapse 59:359-67. 2006
    ..01 and 0.1 mg/kg, but significantly decreased by 1 mg/kg of 8-OH-DPAT. Overall, the systemic administration of 8-OH-DPAT preferentially affects the activity of spontaneously active A10 DA neurons in rats...
  41. pmc Peptidic delta opioid receptor agonists produce antidepressant-like effects in the forced swim test and regulate BDNF mRNA expression in rats
    Mary M Torregrossa
    Neuroscience Program, University of Michigan, Ann Arbor, MI 48109, USA
    Brain Res 1069:172-81. 2006
    ....
  42. ncbi The role of NR2B containing NMDA receptor in place preference conditioned with morphine and natural reinforcers in rats
    Yao Ying Ma
    Neuroscience Research Institute and Department of Neurobiology, Peking University Health Science Center, Key Laboratory of Neuroscience, The Ministry of Education and Ministry of Public Health, 38 Xueyuan Road, Beijing 100083, PR China
    Exp Neurol 200:343-55. 2006
    ..Taking together, these findings suggested that NR2B containing NMDA receptor may be more involved with morphine reward rather than natural rewards, and that antagonism of NR2B may have a potential for the treatment of morphine abuse...
  43. ncbi Ghrelin inhibits inflammatory pain in rats: involvement of the opioid system
    Valeria Sibilia
    Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milano, Via Vanvitelli, 32, 20129 Milan, Italy
    Neuropharmacology 51:497-505. 2006
    ..c.), did not antagonize antinociception elicited by i.p. ghrelin. Overall these data indicate that ghrelin exerts an inhibitory role on inflammatory pain through an interaction with the central opioid system...
  44. pmc Neuroprotection by tamoxifen in focal cerebral ischemia is not mediated by an agonist action at estrogen receptors but is associated with antioxidant activity
    Yonghua Zhang
    Neural and Vascular Biology Theme, Ordway Research Institute, 150 New Scotland Avenue, Albany, NY 12208, USA
    Exp Neurol 204:819-27. 2007
    ..These data are consistent with at least part of tamoxifen's marked neuroprotection in focal cerebral ischemic injury being due to its antioxidant activity but not by an acute action on estrogen receptors (212 words)...
  45. ncbi Pretreatment with subeffective doses of Rimonabant attenuates orexigenic actions of orexin A-hypocretin 1
    Inmaculada Crespo
    Departamento de Psicobiologia, Facultad de Psicologia, Universidad Complutense de Madrid, Campus de Somosaguas E 28223 Madrid, Spain
    Neuropharmacology 54:219-25. 2008
    ....
  46. pmc Separation of the convulsions and antidepressant-like effects produced by the delta-opioid agonist SNC80 in rats
    Emily M Jutkiewicz
    Department of Pharmacology, University of Michigan Medical School, 1301 MSRB III, Ann Arbor, MI 48109 0632, USA
    Psychopharmacology (Berl) 182:588-96. 2005
    ..Therefore, determining how to separate the convulsive and antidepressant-like characteristics of these compounds is essential for their potential clinical use...
  47. ncbi The possible role of the NO-cGMP pathway in nociception: different spinal and supraspinal action of enzyme blockers on rat dorsal horn neurones
    Ulrich Hoheisel
    Institut fur Pharmakologie und Toxikologie, Charite, Humboldt Universitat, Berlin, Germany
    Pain 117:358-67. 2005
    ..The results show that at the spinal level, a lack of cGMP and NO has an excitatory action on dorsal horn neurones, whereas supraspinally an elevated level of cGMP is excitatory...
  48. ncbi Dopamine and adenosine receptor interaction as basis for the treatment of Parkinson's disease
    Nicola Simola
    Department of Toxicology and Centre of Excellence for Neurobiology of Dependence, University of Cagliari, 09124 Cagliari, Italy
    J Neurol Sci 248:48-52. 2006
    ..The prospective of providing additional antitremor benefits considerably enhances the therapeutic potential of A(2A) antagonists...
  49. ncbi Effects and mechanisms of supraspinal administration of rat/mouse hemokinin-1, a mammalian tachykinin peptide, on nociception in mice
    Cai Yun Fu
    Department of Biochemistry and Molecular Biology, School of Life Science, Lanzhou University, 222 Tian Shui South Road, Lanzhou 730000, People s Republic of China
    Brain Res 1056:51-8. 2005
    ..c.v. administration of r/m HK-1...
  50. ncbi Limited brain diffusion of the glucocorticoid receptor agonist RU28362 following i.c.v. administration: implications for i.c.v. drug delivery and glucocorticoid negative feedback in the hypothalamic-pituitary-adrenal axis
    A B Francis
    Campus Box 345, University of Colorado at Boulder, Boulder, CO 80309, USA
    Neuroscience 141:1503-15. 2006
    ....
  51. ncbi Pronociceptive role of peripheral and spinal 5-HT7 receptors in the formalin test
    Héctor I Rocha-González
    Departamento de Farmacobiologia, Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional, Calzada de los Tenorios 235, Colonia Granjas Coapa, 14330 Mexico, D F, Mexico
    Pain 117:182-92. 2005
    ..Data suggest that 5-HT7, but not 5-HT1A, receptors play a pronociceptive role in peripheral and spinal sites in the rat formalin test...
  52. ncbi ABT-594 (a nicotinic acetylcholine agonist): anti-allodynia in a rat chemotherapy-induced pain model
    James J Lynch
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Department R4N5, Bldg AP9A LL, 100 Abbott Park Road, Abbott Park, IL 60064 6115, USA
    Eur J Pharmacol 509:43-8. 2005
    ....
  53. ncbi Large-amplitude 5-HT1A receptor activation: a new mechanism of profound, central analgesia
    F C Colpaert
    Centre de Recherche Pierre Fabre, 17, avenue Jean Moulin, 81106 Castres Cedex, France
    Neuropharmacology 43:945-58. 2002
    ....
  54. ncbi Noradrenaline transporter blockers raise extracellular dopamine in medial prefrontal but not parietal and occipital cortex: differences with mianserin and clozapine
    V Valentini
    Department of Toxicology and Centre of Excellence Neurobiology of Addiction, University of Cagliari, Cagliari, Italy
    J Neurochem 88:917-27. 2004
    ..This process, although extensive in the PFCX, appears insignificant in the ParCX and OccCX, probably as a result of the higher ratio of NA to DA resulting in exclusion of DA from NA transporter...
  55. ncbi Novel mechanism of enhanced nociception in a model of AIDS therapy-induced painful peripheral neuropathy in the rat
    Elizabeth K Joseph
    Department of Medicine, Division of Neuroscience and Biomedical Sciences Program, and UCSF NIH Pain Center, University of California, San Francisco, CA 94143 0440, USA
    Pain 107:147-58. 2004
    ..This study provides evidence for a novel, calcium-dependent, mechanism for neuropathic pain in a model of AIDS therapy-induced painful peripheral neuropathy...
  56. ncbi Effects on cocaine and food self-administration of (+)-HA-966, a partial agonist at the glycine/NMDA modulatory site, in rats
    Luigi Cervo
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy
    Psychopharmacology (Berl) 173:124-31. 2004
    ..Since this effect was observed studying only one dose of cocaine and considering the characteristic bell-shaped curve generated by cocaine in self-administration studies under FR schedules, the precise nature of the effect is not clear...
  57. ncbi Prolonged nicotine dependence associated with extended access to nicotine self-administration in rats
    Neil E Paterson
    Department of Neuropharmacology CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 173:64-72. 2004
    ..Most nicotine self-administration (NSA) studies in rats are performed under limited-access conditions. Few studies have examined the relationship between nicotine dependence and NSA...
  58. ncbi Further evidence for the mediation of both subtypes of dopamine D1/D2 receptors and cerebral neuropeptide Y (NPY) in amphetamine-induced appetite suppression
    Dong Yih Kuo
    Department of Physiology, Chung Shan Medical University, Taichung City, Taiwan 402, ROC
    Behav Brain Res 147:149-55. 2003
    ..Taken together, the present results confirmed that both subtypes of D1 and D2 receptors and cerebral NPY were involved in the anorectic action of AMPH...
  59. ncbi A peripheral cannabinoid mechanism suppresses spinal fos protein expression and pain behavior in a rat model of inflammation
    A G Nackley
    Neuroscience and Behavior Program, Department of Psychology, The University of Georgia, Athens, GA 30602 3013, USA
    Neuroscience 117:659-70. 2003
    ....
  60. pmc Pharmacological characterisation of a rat model of incisional pain
    Garth T Whiteside
    Neuropharmacology, Purdue Pharma LP, 6 Cedar Brook Drive, Cranbury, NJ 08512, USA
    Br J Pharmacol 141:85-91. 2004
    ....
  61. ncbi Reversal of phencyclidine-induced dopaminergic dysregulation by N-methyl-D-aspartate receptor/glycine-site agonists
    Daniel C Javitt
    Nathan Kline Institute for Psychiatric Research, NYU School of Medicine, Orangeburg, NY, USA
    Neuropsychopharmacology 29:300-7. 2004
    ..These findings demonstrate effective doses of glycine for use in animal models of schizophrenia, and support recent clinical studies showing the effectiveness of NMDA agonists in the treatment of persistent symptoms of schizophrenia...
  62. ncbi Intraseptal infusion of oxotremorine impairs memory in a delayed-non-match-to-sample radial maze task
    J G Bunce
    Department of Psychology, University of Connecticut, Storrs, CT 06269, USA
    Neuroscience 121:259-67. 2003
    ....
  63. ncbi Effects of cocaine in rats exposed to heroin
    Francesco Leri
    Department of Psychology, University of Guelph, Canada
    Neuropsychopharmacology 28:2102-16. 2003
    ..In response to cocaine, however, DA activity in the Acb was significantly lower in rats withdrawn from the highest dose of heroin...
  64. ncbi Inhibition of [18F]FP-TZTP binding by loading doses of muscarinic agonists P-TZTP or FP-TZTP in vivo is not due to agonist-induced reduction in cerebral blood flow
    Kazuaki Shimoji
    Positron Emission Tomography Department, Clinical Center, NIMH, National Institutes of Health, Bethesda, Maryland 20892, USA
    Synapse 50:151-63. 2003
    ..The methods employed here may also be of interest to evaluate physiological effects of blocking agents utilized to validate other radiopharmaceuticals...
  65. ncbi Peripheral and central sites of action for A-85380 in the spinal nerve ligation model of neuropathic pain
    Lynne E Rueter
    Neurological Research, D4N5 AP9A, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 6115, USA
    Pain 103:269-76. 2003
    ..Together these data further support the idea that different mechanisms underlie different pain states and suggest that the effects of NNR agonists in neuropathic pain may be due in part to peripheral actions of the compounds...
  66. ncbi The mGluR5 antagonist MPEP decreased nicotine self-administration in rats and mice
    Neil E Paterson
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 167:257-64. 2003
    ..Metabotropic glutamate receptors 5 (mGluR5) are found in the nucleus accumbens and may play a role in modulating the post-synaptic response to both glutamate and dopamine...
  67. ncbi The effects of endogenous interleukin-1 bioactivity on locus coeruleus neurons in response to bacterial and viral substances
    Mark K Borsody
    Department of Psychiatry and Behavioral Sciences, Emory University Medical School, Emory West Campus, 1256 Briarcliff Road, N E, Atlanta, GA 30306, USA
    Brain Res 1007:39-56. 2004
    ..In contrast, poly(I)/(C) increased the activity of LC neurons but this did not critically involve IL-1 receptors in the LC...
  68. ncbi Evidence that CB-1 and CB-2 cannabinoid receptors mediate antinociception in neuropathic pain in the rat
    David A Scott
    The Department of Pharmacology, University of Melbourne, Melbourne, VIC 3010, Australia
    Pain 109:124-31. 2004
    ..005). These results suggest a role for CB-2 receptor-mediated antinociception in both acute and neuropathic pain in addition to centrally located CB-1 mechanisms...
  69. ncbi Roles of opioid receptor subtypes on the antinociceptive effect of intrathecal sildenafil in the formalin test of rats
    Myung Ha Yoon
    Department of Anesthesiology and Pain Medicine, Chonnam National University, Medical School, Gwangju, Republic of Korea
    Neurosci Lett 441:125-8. 2008
    ..Both mu and delta opioid receptors are involved. However, it seems that kappa opioid receptors play in the effect of sildenafil...
  70. ncbi Blockade of peripheral 5HT3 receptor attenuates the formalin-induced nocifensive behavior in persistent temporomandibular joint inflammation of rat
    Keiichiro Okamoto
    Department of Anatomy and Neurobiology, Wakayama Medical University, Kimiidera 811 1, Wakayama City 640 0012, Japan
    Neurosci Lett 367:259-63. 2004
    ....
  71. ncbi Fluoxetine administration potentiates the effect of olanzapine on locus coeruleus neuronal activity
    Matthew A Seager
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    Biol Psychiatry 55:1103-9. 2004
    ..g., fluoxetine) have shown great promise in the treatment of these treatment-resistant patients. As of yet, the precise neural mechanisms responsible for the beneficial clinical effect of these combinations are not completely understood...
  72. ncbi Teneurin proteins possess a carboxy terminal sequence with neuromodulatory activity
    Liqun Wang
    Department of Zoology, University of Toronto, 25 Harbord Street, Toronto, Canada M5S 3G5
    Brain Res Mol Brain Res 133:253-65. 2005
    ..These data indicate that TCAP may possess functions that are independent of the teneurin proprotein and together, the teneurins and TCAP, may represent a novel system to regulate neuronal function and emotionality...
  73. ncbi Behavioural effects of the novel AMPA/GluR5 selective receptor antagonist NS1209 after systemic administration in animal models of experimental pain
    Gordon Blackburn-Munro
    Department of Pharmacology, Neurosearch A S, Pederstrupvej 93, DK 2750 Ballerup, Denmark
    Neuropharmacology 47:351-62. 2004
    ..Thus, systemic administration of NS1209 at non-ataxic doses has marked analgesic actions comparable to those of morphine in a range of animal models of experimental pain...
  74. ncbi Continuous perfusion with morphine of the orbitofrontal cortex reduces allodynia and hyperalgesia in a rat model for mononeuropathy
    Hassen A Al Amin
    Department of Psychiatry, Faculty of Medicine, American University of Beirut, Beirut, Lebanon
    Neurosci Lett 364:27-31. 2004
    ..The observed results support the idea that this area is a component of a flexible cerebral network involved in pain processing and perception...
  75. ncbi NPY mediates the feeding elicited by muscimol injections into the nucleus accumbens shell
    Thomas R Stratford
    Laboratory of Integrative Neuroscience and Department of Psychology m c 285, University of Illinois at Chicago, 1007 W Harrison Street, Chicago, IL 60607, USA
    Neuroreport 15:2673-6. 2004
    ..Intra-AcbSh muscimol elicited a large increase in food intake which was potently suppressed by blocking either central Y1 or Y5 receptors. Our results suggest that the AcbSh influences food intake, in part, through the release of NPY...
  76. ncbi MGlu5 antagonism impairs exploration and memory of spatial and non-spatial stimuli in rats
    Gert R J Christoffersen
    Department of Biology, August Krogh Building, University of Copenhagen, DK 2100 Copenhagen, Denmark
    Behav Brain Res 191:235-45. 2008
    ..However, the fact that prelimbic administration of MPEP inhibited retention without reducing exploration shows that memory formation was also impacted directly by prelimbic mGlu5 in both spatial and non-spatial learning...
  77. ncbi Increased nociceptive response in mice lacking the adenosine A1 receptor
    Wei ping Wu
    Department of Neurotec, Division of Clinical Neurophysiology, Karolinska Institutet, Karolinska University Hospital Huddinge, S 141 86 Stockholm, Sweden
    Pain 113:395-404. 2005
    ..A1 receptors also contribute to the antinociceptive effect of spinal morphine. Selective A1 receptor agonists may be tested clinically as analgesics, particularly under conditions of neuropathic pain...
  78. ncbi Antidepressant-like effects of uridine and omega-3 fatty acids are potentiated by combined treatment in rats
    William A Carlezon
    Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts, USA
    Biol Psychiatry 57:343-50. 2005
    ..We also examined the effects of omega-3 fatty acids (OMG), which increase membrane fluidity and reportedly have antidepressant effects in humans, alone and in combination with uridine...
  79. ncbi Behavioral effects of intracerebroventricular microinfusion of agmatine in adult rats
    Ping Liu
    Department of Anatomy and Structural Biology, School of Medical Sciences, University of Otago, Dunedin, New Zealand
    Behav Neurosci 122:557-69. 2008
    ..These results suggest that the behavioral effects of agmatine are task- and dose-dependent, and agmatine may be an anxiolytic and memory modulator...
  80. ncbi [The new 2005 resuscitation guidelines of the European Resuscitation Council: comments and supplements]
    V Wenzel
    Univ Klinik für Anaesthesie und Allgemeine Intensivmedizin, Medizinische Universitat, Anichstrasse 35, 6020, Innsbruck, Austria
    Anaesthesist 55:958-66, 968-72, 974-9. 2006
    ..b>Drug administration routes for adults and children: first choice IV, second choice intraosseous, third choice endobronchial [..
  81. ncbi [Comments on the 2010 guidelines on cardiopulmonary resuscitation of the European Resuscitation Council]
    V Wenzel
    Univ Klinik für Anaesthesie und Intensivmedizin, Medizinische Universitat Innsbruck, Anichstr 35, 6020, Innsbruck, Osterreich
    Anaesthesist 59:1105-23. 2010
    ..Supraglottic airway devices are alternatives to tracheal intubation. Drug administration routes for adults and children: first choice i.v., second choice intraosseous (i.o.)...
  82. ncbi The inhalation of drugs: advantages and problems
    Joseph L Rau
    Department of Cardiopulmonary Care Sciences, Georgia State University, Atlanta, USA
    Respir Care 50:367-82. 2005
    ..Potential improvements in aerosol delivery include better standardization of function and patient use, greater reliability, and reduction of drug loss...
  83. ncbi Implementation of an integrated drug information system for inpatients to reduce medication errors in administering stage
    Tun Yang Lawrence Sung
    Graduate Institute of Medical Informatics, Taipei Medical University, Taipei, Taiwan
    Conf Proc IEEE Eng Med Biol Soc 2008:743-6. 2008
    ..on a computerized drug cart and could provide patients' data, drug information with drug images, drug administration routes, drug interactions, and intravenous drug compatibility information...
  84. ncbi Proteinuria in a placebo-controlled study of basic fibroblast growth factor for intermittent claudication
    L T Cooper
    Mayo Clinic and Foundation, Cardiovascular Division, Rochester, MN 55905, USA
    Vasc Med 6:235-9. 2001
    ..Future clinical trials of bFGF protein should carefully monitor renal function and consider alternative dosing schedules and drug administration routes.
  85. ncbi Sedation in the geriatric patient
    Julián López-Jiménez
    Universidad Internacional de Cataluña, Espana
    Med Oral 9:45-55. 2004
    ..A description is made of the recommended psychoactive drug administration routes according to the associated pathology and of the most frequent pharmacological interactions with the ..
  86. ncbi [Pharmacokinetics (PK) of mAbs]
    Gilles Paintaud
    Universite Francois Rabelais de Tours, lt lt Génétique, Immunothérapie, chimie et cancer gt gt, France
    Med Sci (Paris) 25:1057-62. 2009
    ..Complex PK models are needed to describe satisfactorily their fate in the body and their concentration-effect relationship...
  87. ncbi Optimising antimicrobial therapy in diabetic foot infections
    Nalini Rao
    Division of Infectious Disease, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15232 1381, USA
    Drugs 67:195-214. 2007
    ..Certain other organisms, such as Pseudomonas aeruginosa and Enterococcus spp., while potentially pathogenic, are often colonisers that do not require targeted therapy...
  88. ncbi A novel stent for percutaneous heart valve implantation: first in vitro results
    C Marchand
    LPMT, ENSISA, CNRS UMR 7189, Mulhouse, France
    J Biomech Eng 132:054502. 2010
    ..Prosthesis static and dynamic regurgitation are evaluated and show values close to those obtained with other commercially available prostheses...
  89. ncbi Abdominal aorta anastomosis in rats and stable gastric pentadecapeptide BPC 157, prophylaxis and therapy
    M Hrelec
    Department of Pharmacology and Pathology, Medical Faculty, University of Zagreb, Zagreb, Croatia
    J Physiol Pharmacol 60:161-5. 2009
    ....
  90. pmc Post-retrieval disruption of a cocaine conditioned place preference by systemic and intrabasolateral amygdala beta2- and alpha1-adrenergic antagonists
    Rick E Bernardi
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97239, USA
    Learn Mem 16:777-89. 2009
    ..These systemic and site-specific injections, as well as the FOS immunohistochemical analyses, implicate the importance of specific noradrenergic signaling mechanisms within the BLA in post-retrieval plasticity...
  91. ncbi Specific immunotherapy in pollen allergy
    Michael Wallner
    Christian Doppler Laboratory for Allergy Diagnosis and Therapy, Department of Molecular Biology, University of Salzburg, Hellbrunnerstralle 34, A 5020 Salzburg, Austria
    Curr Opin Mol Ther 9:160-7. 2007
    ..These new formulations, for use in the routine management of pollen allergies, should become available in the near future...
  92. ncbi Opioid rotation in patients with cancer: a review of the current literature
    Athina Vadalouca
    Pain Therapy and Palliative Care, Aretaieion University Hospital, Athens, Greece
    J Opioid Manag 4:213-50. 2008
    ..However, too much work is to be done to further individualize analgesic therapy for patients with cancer...
  93. ncbi Drug administration via nasogastric tube
    Sonya Clarke
    School of Nursing and Midwifery, Queen s University, Belfast
    Paediatr Nurs 20:32. 2008
    ..Findings of the review are summarised here in relation to using the nasogastric tube to administer medication to children with the aim of informing practice and improving safety...
  94. ncbi Analysis of the chronic intake of and withdrawal from diazepam on emotional reactivity and sensory information processing in rats
    J De Ross
    Instituto de Neurociências and Comportamento INeC, Campus USP, 14040 901, Ribeirao Preto, SP, Brazil
    Prog Neuropsychopharmacol Biol Psychiatry 32:794-802. 2008
    ..All these findings are indicative of a sensitization of the neural substrates of aversion in diazepam-withdrawn animals without concomitant changes on the processing of sensory information...
  95. ncbi Evaluation of transmission of Brucella abortus strain 19 in bison by intravaginal, intrauterine, and intraconjunctival inoculation
    Samantha R Uhrig
    Department of Clinical Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    J Wildl Dis 49:522-6. 2013
    ..abortus. The seroconversion of four of eight VI bison indicated exposure of the immune system to the agent and the need for further studies on venereal transmission in bison...
  96. pmc Glossitis and tongue trauma subsequent to administration of an oral medication, using an udder infusion cannula, in a horse
    Mark C Fuller
    Department of Health Management, Atlantic Veterinary College, University of Prince Edward Island, 550 University Avenue, Charlottetown, Prince Edward Island
    Can Vet J 48:845-7. 2007
    ..The tongue appeared to have been punctured inadvertently. The horse recovered after treatment with intravenous fluid, antibiotics, and anti-inflammatory drugs. Administering oral medication by this method should be discouraged...
  97. ncbi Ventilatory and cardiovascular actions of centrally administered trout tachykinins in the unanesthetized trout
    Jean Claude Le Mevel
    Laboratoire de Traitement de l Information Médicale, INSERM U650, Faculte de Medecine et des Sciences de la Sante, Universite de Bretagne Occidentale, 22 avenue Camille Desmoulins, CS 93837, 29238 Brest Cedex 3, France
    J Exp Biol 210:3301-10. 2007
    ....
  98. ncbi Monoamine oxidase inhibition dramatically prolongs the duration of nicotine withdrawal-induced place aversion
    Karine Guillem
    Laboratoire de Neuropsychobiologie des Désadaptations UMR CNRS 5541, Universite de Bordeaux 2, Bordeaux, France
    Biol Psychiatry 63:158-63. 2008
    ....
  99. ncbi Importance of cocaine- and amphetamine-regulated transcript peptide in the central nucleus of amygdala in anxiogenic responses induced by ethanol withdrawal
    Manoj P Dandekar
    Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University Campus, Nagpur, India
    Neuropsychopharmacology 33:1127-36. 2008
    ..We suggest that CART may mediate the early signs of anxiety-like behavior induced by ethanol withdrawal within the neuroanatomical framework of the CeA...
  100. ncbi [Criteria for delegating the safe hospital administration of drug therapy via natural route to nurses aids in hospital]
    Alvisa Palese
    Universita Degli Studi di Udine
    Assist Inferm Ric 31:228-33. 2012
    ..To assess if and how many patients admitted to hospital could receive the drug therapy via natural route by specialized nurses aids (OSSc)...
  101. ncbi Botulinum neurotoxins and formalin-induced pain: central vs. peripheral effects in mice
    Siro Luvisetto
    Istituto di Neuroscienze del CNR, Psicobiologia e Psicofarmacologia, Centro Europeo di Ricerca sul Cervello, Via del Fosso di Fiorano 64, 00143 Roma, Italy
    Brain Res 1082:124-31. 2006
    ..Such data suggest BoNTs as a useful tool in the studies aimed at the comprehension of the mechanisms of inflammatory pain...

Research Grants75

  1. Hyaluronan facilitates hematopoietic recovery following ionizing irradiation
    Sophia K Khaldoyanidi; Fiscal Year: 2010
    ..In addition, we will test different drug administration routes including oral and subcutaneous...
  2. NICOTINE DEPENDENCE--TAILORING AND PREFERENCE RESEARCH
    Nina Schneider; Fiscal Year: 2001
    ..Several new scales will be tested: one which assesses withdrawal via anchored responding and a set of scales for testing preference with an ultimate aim of developing a tool for easily matching smokers to therapy. ..
  3. OPIOID DEPRESSION OF RESPIRATORY NEURONS
    PETER LALLEY; Fiscal Year: 2003
    ..It will also test a new method that may alleviate opioid-induced depression of respiration without affecting analgesia, and counteract respiratory depression by overdose of opioids. ..
  4. Methylated Genes as Serum Biomarkers for Lung Cancer
    Mark Kris; Fiscal Year: 2008
    ..Future studies will be required to establish this technique as a reliable diagnostic tool to guide the management of patients with lung cancer. ..
  5. RCT of Russian IDU Peer Network HIV Prevent Intervention
    Carl Latkin; Fiscal Year: 2007
    ..abstract_text> ..
  6. Protective Influence of Residential Learning Communities
    SEAN MCCABE; Fiscal Year: 2006
    ..At each measurement point, participants will complete a set of measures that assess substance use behaviors and constructs addressed by RLCs. ..
  7. Bladder Regulation by Corticotropin-Releasing Factor
    RITA VALENTINO; Fiscal Year: 2006
    ..These studies unite complementary expertise from laboratories in urology and basic neuroscience to increase our knowledge of the central regulation of urinary function in normal and pathological state. [unreadable] [unreadable]..
  8. Giant Cell Myocarditis Treatment Trial Pilot Study
    COOPER LESLIE; Fiscal Year: 2005
    ..Abstract Not Provided ..
  9. Intracerebral Infusion of Radiolabeled Specific Antibody
    John Sampson; Fiscal Year: 2006
    ..abstract_text> ..
  10. Dendritic Cell Immunotherapy of Malignant Gliomas
    John Sampson; Fiscal Year: 2006
    ..abstract_text> ..
  11. Training Program in Neurovirology
    HOWARD GENDELMAN; Fiscal Year: 2006
    ....
  12. Promoter-Based Mapping of Amygdala Microcircuits
    Donald Rainnie; Fiscal Year: 2006
    ..These experiments will advance our understanding of the primate amygdala, a necessary step for understanding the pathophysiology of and development of novel treatments for disorders of alcohol addiction and other psychiatric disorders. ..
  13. Gene Repair in signal Transduction after CNS Injury
    Philip Liu; Fiscal Year: 2006
    ..abstract_text> ..
  14. Comorbid childhood anxiety and asthma
    Renee Goodwin; Fiscal Year: 2006
    ..That study will involve a longitudinal epidemiologic preventive intervention study aimed at reducing the risk of anxiety disorders among pediatric asthma/allergy patients. ..
  15. Development of CART for HIV adherence and cocaine abuse
    Karen Ingersoll; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  16. LATENCY AND REACTIVATION TUBERCULOSIS
    YUKARI MANABE; Fiscal Year: 2006
    ..Appropriate animal models are critical to the successful development of tuberculosis vaccines, new drugs and better diagnostic tests for tuberculosis. ..
  17. Treatment of Early Stage Multiple Myeloma
    S Rajkumar; Fiscal Year: 2006
    ..BM angiogenesis will be studied using immunostaining (IHC) for CD34 and an in vitro human angiogenesis assay. VEGF expression will be studied using IHC and quantitative RT-PCR. ..
  18. A Network & Dyad HIV Prevention Intervention for Intravenous Drug User
    Carl Latkin; Fiscal Year: 2007
    ..Main outcome measures will be self-reported sex and injection risk behaviors. Self-reports will be cross-validated by urinalysis of STIs. [unreadable] [unreadable]..
  19. Hyperalgesia in Methadone Patients: Can it be Treated?
    Margaret Compton; Fiscal Year: 2007
    ..abstract_text> ..
  20. Supraspinal Modulation of Neuropathic Pain
    Bradley Taylor; Fiscal Year: 2007
    ..abstract_text> ..
  21. Case Management Alternatives for African American Women at High Risk for HIV
    Hilary L Surratt; Fiscal Year: 2010
    ....
  22. Phencyclidine Abuse & Psychosis: Biomedical Mechanisms
    Daniel C Javitt; Fiscal Year: 2010
    ....
  23. CD47 as a neurovascular target for stroke therapy
    Eng H Lo; Fiscal Year: 2010
    ..Proof-of-concept data collected here may lead to the development of CD47 as a novel neurovascular target for stroke therapy. ..
  24. How does Motivational Interviewing Work? Mechanisms of Action in Project CHOICES
    Karen Ingersoll; Fiscal Year: 2009
    ..Once these components are identified, new, science-based interventions could be developed for a range of health-threatening behaviors for people with chronic illnesses including addictive disorders. ..
  25. NEUROPEPTIDERGIC INHIBITION OF SPINAL PAIN TRANSMISSION
    Bradley Taylor; Fiscal Year: 2008
    ..We predict that the activity of this population of spinal neurons will be decreased by NPY administration, and increased by NPY knockdown. ..
  26. The Role of NF-kappaB in Chemotherapy Resistance
    James Cusack; Fiscal Year: 2009
    ..This proposal has the potential to completely alter chemotherapy strategies based on our understanding of the role of NF-kappaB in chemotherapy resistance. ..
  27. Alcohol, Sleep and Brain Development
    IAN COLRAIN; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  28. Oral Androgen Administration and Function in Man
    JOHN AMORY; Fiscal Year: 2008
    ..Matsumoto M.D., Director, Clinical Research Unit VA-Puget Sound and Professor of Medicine, University of Washington School of Medicine will co-mentor this award. [unreadable] [unreadable]..
  29. Systems Biology of Angiogenesis: from Molecules to Therapy
    BRIAN ANNEX; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  30. STEM CELLS AND AGING
    Stewart Sell; Fiscal Year: 2008
    ..The results of these experiments should provide critical proof for one of the most important hypothetical properties of adult stem cells. ..
  31. Estrogen & Progesterone Effects on Orthostatic Tolerance
    NINA STACHENFELD; Fiscal Year: 2010
    ..We also expect that the data in these studies will provide a basis to study the impact of sex hormones on diseases related to compromised peripheral circulation, such as hypertension, Raynaud's phenomenon and diabetes ..
  32. LEVODOPA PHARMACOKINETICS AND PHARMACODYNAMICS
    John Nutt; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  33. Progesterone Modulation of Pulsatile GnRH Secretion
    CHRISTOPHER MCCARTNEY; Fiscal Year: 2007
    ..McCartney's development into an independent patient-oriented investigator in the field of reproductive endocrinology. [unreadable] [unreadable]..
  34. Antibody mediated intracellular bacterial elimination
    Gary Winslow; Fiscal Year: 2006
    ....
  35. NEURONAL ELECTROPHYSIOLOGY IN HIV DEMENTIA
    HOWARD GENDELMAN; Fiscal Year: 2001
    ....
  36. ALTERNATIVE THERAPIES FOR MENOPAUSE: A RANDOMIZED TRIAL
    Katherine Newton; Fiscal Year: 2004
    ....
  37. Cadmium Teratogenesis to murine strains proteomics
    Michael Collins; Fiscal Year: 2003
    ..abstract_text> ..
  38. HIV ADHERENCE MENTORED RES. SCIENTIST DEV. AWARD
    Karen Ingersoll; Fiscal Year: 2003
    ..abstract_text> ..
  39. Nocardia: A Novel Environmental Agent For Parkinsonism?
    Peter LeWitt; Fiscal Year: 2003
    ..These outcomes will be significant because they should add to our understanding of the neurodegenerative process in PD, and could lead to improved means of diagnosis and treatment for individuals with this disorder. ..
  40. REGULATION OF BBB GLUT1 GLUCOSE TRANSPORTER
    William Pardridge; Fiscal Year: 2002
    ..These studies will provide insight into molecular mechanisms of regulation of a step crucial to the maintenance of cerebral intermediary metabolism, i.e., the continuous transport of glucose across the blood-brain barrier in vivo. ..
  41. PASSIVE IMMUNITY TO COCAINE USING NOVEL HUMAN ANTIBODIES
    Andrew Norman; Fiscal Year: 2003
    ..These studies will form the basis for an application to the FDA for advancement of an identified human monoclonal anti-cocaine antibody to Phase II clinical trials to determine the efficacy of a passive immunotherapy of cocaine abuse. ..
  42. Behavioral Despair and Interleukin-1
    Terrence Deak; Fiscal Year: 2002
    ..abstract_text> ..
  43. PILOT TRIAL OF THALAMIC STIMULATION FOR EPILEPSY
    Robert Fisher; Fiscal Year: 2001
    ..A consortium of centers experienced in epilepsy research will collaborate on this project, which will move brain stimulation for epilepsy into the realm of a testable new therapy for intractable seizures. ..
  44. PAIN, OPIOID ANALGESIA AND BLOOD PRESSURE CONTROL
    Bradley Taylor; Fiscal Year: 2002
    ..The results of these studies will facilitate our understanding of the mechanisms that contribute to chronic pain in the hypertensive patient. ..
  45. High-Density ERP mapping & FMRI
    Daniel Javitt; Fiscal Year: 2002
    ..The equipment will also permit monitoring of background EEG during both human and animal studies. Software is requested for state-of-the-art ERP dipole mapping and ERP/MRI co-registration. ..
  46. BIODEGRADABLE HYDROPHILIC POLYACETALS
    MIKHAIL PAPISOV; Fiscal Year: 2001
    ..abstract_text> ..
  47. Neurobiology of Orexin/Hypocretin-Induced Arousal
    CRAIG BERRIDGE; Fiscal Year: 2004
    ..These studies will provide a better understanding of the neurobiology of orexin, the neurobiology of sleep and waking, and the potential role of orexin in narcolepsy and other disorders of arousal. ..
  48. BIOGENIC AMINE SYSTEMS, CRF, AND STRESS
    RITA VALENTINO; Fiscal Year: 2005
    ..Like the previous K02 award, the K05 award will promote future career development by providing stable salary support and flexibility to enhance technical skills and conceptual bases and promoting leadership. ..
  49. Murine strain sensitivity to cadmium teratogenesis
    Michael Collins; Fiscal Year: 2005
    ..An additive oligogenic model involving nine genes for the induction of the forelimb defect has been proposed. ..
  50. Vascular Protection in Acute Ischemic Stroke
    Susan Fagan; Fiscal Year: 2005
    ..Collectively, the successful completion of the research summarized in this proposal can be expected to contribute to the development of methods to make reperfusion safer, and therefore more accessible, to human stroke patients. ..
  51. Antisense imaging of brain gene expression in vivo
    William Pardridge; Fiscal Year: 2005
    ..This technology could be extended to humans and to other organs. At present, there is no parallel technology that enables the non-invasive in vivo imaging of "any gene in any person," which is the goal of this work. ..
  52. Genetic Risk Factors for Portopulmonary Hypertension
    Steven Kawut; Fiscal Year: 2005
    ..In addition, this pilot study could suggest targeted preventative or therapeutic modalities, leading to clinical trials for an "orphan" disease routinely excluded from other research programs and trials of therapy. ..
  53. BRAIN/PELVIC VISCERA INTERACTIONS IN PSYCHIATRIC DISEASE
    RITA VALENTINO; Fiscal Year: 2001
    ....
  54. Pharmacotherapy for Minor Depression
    Robert Howland; Fiscal Year: 2004
    ..The results of this study will have profound public health implications by improving our understanding of the efficacy of SJW and standard antidepressants for the treatment of MinorD. ..
  55. PROTEASE INHIBITOR RELATED ATHEROSCLEROSIS IN HIV
    Andrew Carr; Fiscal Year: 2005
    ....
  56. Nucleus Accumbens-Mediated Feeding: Output Pathways
    Thomas R Stratford; Fiscal Year: 2010
    ....
  57. Localized modulation of RPE P-gp/MRP activity for back-of-the-eye drug delivery
    Soumyajit Majumdar; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  58. IRON REGULATION & VIRULENCE--MYCOBACTERIUM TUBERCULOSIS
    YUKARI MANABE; Fiscal Year: 2003
    ..Elucidation of this iron-dependent IdeR regulon may lead to the identification of virulence determinants, and novel antigens for vaccines and therapeutics. ..
  59. NITROXIDERGIC CEREBROVASCULAR TONE DURING ANESTHESIA
    Shailendra Joshi; Fiscal Year: 2005
    ..abstract_text> ..
  60. SYSTEMIC LYMPH NODE SPECIFIC AGENTS
    MIKHAIL PAPISOV; Fiscal Year: 2003
    ..If successful, this project will result in the development of a new class of preparations and a new strategy for prophylactic and early post-exposure treatment of bacterial diseases of Category A. ..
  61. SEX HORMONES AND BODY FLUID REGULATION
    NINA STACHENFELD; Fiscal Year: 2003
    ....
  62. TISSUE-SPECIFIC EFFECTS OF PROGESTINS
    KATHRYN HORWITZ; Fiscal Year: 2003
    ..NT-B, and ligand-regulated transcription by full-length PR. The proposed studies address the presently unknown functions of the two PR N-termini. ..
  63. BRAIN CELL APOPTOSIS AFTER INTRACEREBRAL HEMORRHAGE
    ENG LO; Fiscal Year: 2003
    ..Results may be used to improve the clinical management and treatment of intracerebral hemorrhage. ..
  64. Oleylethanolamide derivatives as anti-obesity agents
    Daniele Piomelli; Fiscal Year: 2005
    ....
  65. NEUROBEHAVIORAL MECHANISMS OF DRUG ADDICTION
    STANLEY GLICK; Fiscal Year: 2001
    ..This research may result in novel treatments for addictive disorders in humans. ..
  66. A Decision Support Tool for Adult Sickle Cell Emergency Department Patients
    Paula Tanabe; Fiscal Year: 2010
    ..This knowledge will position the candidate to launch a research career as an investigator who will conduct projects aimed at scientifically evaluating mechanisms to improve the care of persons with SCD in the ED setting. ..
  67. Characterization of a novel brain cannabinoid ligand
    Daniele Piomelli; Fiscal Year: 2010
    ..The objective of our research is to understand how these transmitters are produced and eliminated, and discover innovative medicines that target these processes. ..
  68. PHARMACOLOGY & NEUROSCIENCE TRAINING IN DRUG ABUSE
    STANLEY GLICK; Fiscal Year: 2008
    ..All aspects of the program are administered by the director and an executive committee of administrative and training faculty. ..
  69. NABTC Member Intitution Grant (UCSF Project Leader)
    Susan Chang; Fiscal Year: 2008
    ..The overall goal of this program is to more effectively treat patients with primary brain tumors, especially malignant glioma, with the purpose of increasing the duration and quality of survival. ..
  70. CONTROL OF ENDOCANNABINOID RELEASE IN VIVO
    Daniele Piomelli; Fiscal Year: 2003
    ..Moreover, by uncovering the neurochemical interactions between cocaine and the endogenous cannabinoids, our studies will contribute to the general understanding of substance abuse and neuropsychiatric disorders. ..
  71. Mechanisms of Vascular Injury in the preterm lung
    Suhas Kallapur; Fiscal Year: 2006
    ..The experimental design in this proposal incorporates challenging but, particularly in this environment achievable goals that will provide important knowledge in the pathogenesis of bronchopulmonary dysplasia. ..
  72. RESPONSIVE POLYMER ENGINEERED PROTEIN CONJUGATES
    Allan Hoffman; Fiscal Year: 2001
    ..This action should increase the efficacies of gene, antisense oligonucleotide, and cancer therapies. ..
  73. DIENCEPHALIC MECHANISMS OF DRUG ABUSE
    STANLEY GLICK; Fiscal Year: 2008
    ..The work proposed here may ultimately result in new kinds of treatments for drug abuse. ..