Genomes and Genes
Summary: Abstaining from all food.
Publications364 found, 100 shown here
- Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in manD R Matthews
Diabetologia 28:412-9. 1985..Comparison of a patient's fasting values with the model's predictions allows a quantitative assessment of the contributions of insulin resistance ..
- National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participantsGoodarz Danaei
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
Lancet 378:31-40. 2011..We estimated trends and their uncertainties in mean fasting plasma glucose (FPG) and diabetes prevalence for adults aged 25 years and older in 199 countries and territories.
- The CREB coactivator TORC2 is a key regulator of fasting glucose metabolismSeung Hoi Koo
Peptide Biology Laboratories, Salk Institute for Biological Studies, 10010 N Torrey Pines Rd, La Jolla, California 92037 1002, USA
Nature 437:1109-11. 2005..Glucagon enhances glucose output from the liver during fasting by stimulating the transcription of gluconeogenic genes via the cyclic AMP-inducible factor CREB (CRE binding ..
- Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21Takeshi Inagaki
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Cell Metab 5:415-25. 2007..FGF21 is induced directly by PPARalpha in liver in response to fasting and PPARalpha agonists. FGF21 in turn stimulates lipolysis in white adipose tissue and ketogenesis in liver...
- Impaired glucose tolerance and impaired fasting glycaemia: the current status on definition and interventionN Unwin
Diabetes and Metabolism, School of Clinical Medical Sciences, University of New Castle, UK
Diabet Med 19:708-23. 2002..review the latest information relating to the risks associated with impaired glucose tolerance (IGT) and impaired fasting glycaemia (IFG) for future diabetes and cardiovascular disease (CVD)...
- Trajectories of glycaemia, insulin sensitivity, and insulin secretion before diagnosis of type 2 diabetes: an analysis from the Whitehall II studyAdam G Tabak
Department of Epidemiology and Public Health, University College London, London, UK
Lancet 373:2215-21. 2009..We aimed to characterise trajectories of fasting and postload glucose, insulin sensitivity, and insulin secretion in individuals who develop type 2 diabetes.
- Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1J C Yoon
Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 413:131-8. 2001..Gluconeogenesis is strongly stimulated during fasting and is aberrantly activated in diabetes mellitus...
- Reduced postprandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patientsT Vilsbøll
Department of Internal Medicine F, Gentofte Hospital, University of Copenhagen, Denmark
Diabetes 50:609-13. 2001..2% [7.0-12.5]) and 12 matched healthy subjects. The patients had fasting hyperglycemia (10.7 mmol/l [8.0-14.8]) increasing to 14.6 mmol/l (11.5-21.5) 75 min after meal ingestion...
- The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liverNicola L Beer
Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK
Hum Mol Genet 18:4081-8. 2009..A common GCKR variant (P446L) is reproducibly associated with triglyceride and fasting plasma glucose levels in the general population...
- Adipocytes in subjects with impaired fasting glucose and impaired glucose tolerance are resistant to the anti-lipolytic effect of insulinMuhammad A Abdul-Ghani
Diabetes Division, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
Acta Diabetol 45:147-50. 2008Impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) are two intermediate states in the transition from normal glucose metabolism to type 2 diabetes...
- New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes riskJosee Dupuis
Department of Biostatistics, Boston University School of Public Health, Massachusetts, USA
Nat Genet 42:105-16. 2010..influencing glycemic traits, we performed meta-analyses of 21 genome-wide association studies informative for fasting glucose, fasting insulin and indices of beta-cell function (HOMA-B) and insulin resistance (HOMA-IR) in up to 46,..
- Contributions of fasting and postprandial plasma glucose increments to the overall diurnal hyperglycemia of type 2 diabetic patients: variations with increasing levels of HbA(1c)Louis Monnier
Department of Metabolism, Lapeyronie Hospital, Montpellier, France
Diabetes Care 26:881-5. 2003The exact contributions of postprandial and fasting glucose increments to overall hyperglycemia remain controversial. The discrepancies between the data published previously might be caused by the interference of several factors...
- Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegansSakiko Honjoh
Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Sakyo ku, Kyoto, 606 8502, Japan
Nature 457:726-30. 2009..In mammals, two regimens of dietary restriction, intermittent fasting (IF) and chronic caloric restriction, have proven to extend lifespan and reduce the incidence of age-related ..
- The effect of time-of-day and Ramadan fasting on anaerobic performancesH Chtourou
Research Laboratory Sports Performance Optimization, National Center of Medicine and Science in Sports CNMSS, Tunis, Tunisia
Int J Sports Med 33:142-7. 2012This study was designed to assess the effects of Ramadan-intermittent-fasting (RIF) and time-of-day on muscle power and fatigue during the Wingate test...
- Serum uric acid and risk for development of hypertension and impaired fasting glucose or Type II diabetes in Japanese male office workersN Nakanishi
Department of Social and Environmental Medicine, Course of Social Medicine, Osaka University Graduate School of Medicine F2, Suita Shi, Osaka, Japan
Eur J Epidemiol 18:523-30. 2003..of hypertension (blood pressure > or = 140/90 mmHg and/or medication for hypertension) and impaired fasting glucose (IFG) (a fasting plasma glucose level 6.1-6...
- The metabolic syndrome as predictor of type 2 diabetes: the San Antonio heart studyCarlos Lorenzo
Division of Clinical Epidemiology, University of Texas Health Science Center, San Antonio, Texas 78284 7873, USA
Diabetes Care 26:3153-9. 2003....
- Fasting serum glucose level and cancer risk in Korean men and womenSun Ha Jee
Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea
JAMA 293:194-202. 2005..Diabetes is a serious and costly disease that is becoming increasingly common in many countries. The role of diabetes as a cancer risk factor remains unclear...
- Identifying sources of phthalate exposure with human biomonitoring: results of a 48h fasting study with urine collection and personal activity patternsHolger M Koch
Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum IPA, Burkle de la Camp Platz 1, 44789 Bochum, Germany Electronic address
Int J Hyg Environ Health 216:672-81. 2013..Therefore, we studied urinary phthalate metabolite patterns over a period of strict fasting and additionally recorded personal activity patterns with a diary to investigate non-dietary routes of exposure...
- Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBPAmy K Walker
Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts 02129, USA
Genes Dev 24:1403-17. 2010..During fasting, SREBP-dependent lipid/cholesterol synthesis is rapidly diminished in the mouse liver; however, the mechanism has ..
- Pancreatic fat is negatively associated with insulin secretion in individuals with impaired fasting glucose and/or impaired glucose tolerance: a nuclear magnetic resonance studyMartin Heni
Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany
Diabetes Metab Res Rev 26:200-5. 2010..The aim was to thoroughly quantify the fat content of pancreas sections (caput, corpus, and cauda) and to compare the impact of pancreatic, intrahepatic, and visceral fat on insulin secretion in humans...
- Plasma osteocalcin is inversely related to fat mass and plasma glucose in elderly Swedish menJenny M Kindblom
Center for Bone Research at the Sahlgrenska Academy, Institute of Medicine, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
J Bone Miner Res 24:785-91. 2009..b>Fasting levels of plasma osteocalcin, plasma glucose, serum insulin, and lipids were analyzed in elderly men (75.3 +/- 3...
- Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight lossD E Kelley
Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Am J Physiol 277:E1130-41. 1999..extraction of [9,10 (3)H]oleate) and indirect calorimetry across the leg to determine substrate oxidation during fasting and insulin-stimulated conditions...
- Replication of genome-wide association studies (GWAS) loci for fasting plasma glucose in African-AmericansE Ramos
Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, MSC 5635, Bethesda, MD 20892, USA
Diabetologia 54:783-8. 2011..have significantly enhanced our understanding of the genetic basis of diabetes and related traits, including fasting plasma glucose (FPG). However, the majority of GWASs have been conducted in populations of European ancestry...
- Prevalence of diabetes and impaired fasting glucose in Chinese adults, China National Nutrition and Health Survey, 2002Shuqian Liu
College of Public Health, University of Oklahoma, Oklahoma City, Oklahoma, USA
Prev Chronic Dis 8:A13. 2011..We report the prevalence of type 2 diabetes and impaired fasting glucose (IFG) and the association between diabetes and overweight and obesity in Chinese adults...
- Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscleCarles Canto
Ecole Polytechnique Federale de Lausanne, Switzerland
Cell Metab 11:213-9. 2010During fasting and after exercise, skeletal muscle efficiently switches from carbohydrate to lipid as the main energy source to preserve glycogen stores and blood glucose levels for glucose-dependent tissues...
- Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in miceJulio E Ayala
Vanderbilt NIH Mouse Metabolic Phenotyping Center, Nashville, TN 37232, USA
Dis Model Mech 3:525-34. 2010..We also propose guidelines for the description of methods, presentation of data and interpretation of results. The recommendations presented in this article are based on the experience of the MMPC Consortium and other investigators...
- Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetesChristian Wolfrum
Laboratory of Metabolic Diseases, Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
Nature 432:1027-32. 2004..Pharmacological intervention to inhibit phosphorylation of Foxa2 may be an effective treatment for type 2 diabetes...
- Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: stimulation of eating by 2-arachidonoyl glycerolTim C Kirkham
Department of Psychology, University of Reading, Earley Gate, Whiteknights, Reading RG6 6AL, UK
Br J Pharmacol 136:550-7. 2002..measured anandamide and 2-arachidonoyl glycerol (2-AG) levels in feeding-associated brain regions of rats, during fasting, feeding of a palatable food, or after satiation...
- The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesisYiguo Wang
Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Nature 460:534-7. 2009..Here we show that CRTC2 functions as a dual sensor for ER stress and fasting signals...
- Fasting and differential chemotherapy protection in patientsLizzia Raffaghello
Andrus Gerontology Center, Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA
Cell Cycle 9:4474-6. 2010..Based on the discovery in model organisms that short term starvation (STS or fasting) causes a rapid switch of cells to a protected mode, we described a fasting-based intervention that causes ..
- Effects of APOA5 -1131T>C (rs662799) on fasting plasma lipids and risk of metabolic syndrome: evidence from a case-control study in China and a meta-analysisChunxiao Xu
Department of Epidemiology and Biostatistics, School of Public Health, Zhejiang University, Hangzhou, Zhejiang, PR China
PLoS ONE 8:e56216. 2013..To systematically evaluate the associations between -1131T>C polymorphism and fasting lipid parameters and the risk of MetS, we conducted a case-control study in a Chinese population and a meta-..
- Fasting time and lipid levels in a community-based population: a cross-sectional studyDavinder Sidhu
Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada
Arch Intern Med 172:1707-10. 2012Although current guidelines recommend measuring lipid levels in a fasting state, recent studies suggest that nonfasting lipid profiles change minimally in response to food intake and may be superior to fasting levels in predicting ..
- Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1Joseph T Rodgers
Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Nature 434:113-8. 2005..modulates ageing in several species--controls the gluconeogenic/glycolytic pathways in liver in response to fasting signals through the transcriptional coactivator PGC-1alpha...
- Inhibition of growth hormone signaling by the fasting-induced hormone FGF21Takeshi Inagaki
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Cell Metab 8:77-83. 2008..In this report, we demonstrate that fibroblast growth factor 21 (FGF21), a hormone induced by fasting, causes GH resistance...
- Paradoxical regulation of human FGF21 by both fasting and feeding signals: is FGF21 a nutritional adaptation factor?Takashi Uebanso
Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan
PLoS ONE 6:e22976. 2011..A deletion study of the human FGF21 promoter (-1672 to +230 bp) revealed two fasting signals, including peroxisome proliferator-activated receptor α (PPARα) and glucagon signals, that ..
- Urinary cadmium, impaired fasting glucose, and diabetes in the NHANES IIIGary G Schwartz
Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
Diabetes Care 26:468-70. 2003..To test the hypothesis that exposure to cadmium is associated with impaired fasting glucose and type 2 diabetes, we examined the associations between urinary cadmium and the prevalence of impaired ..
- Fasting plasma C-peptide and micro- and macrovascular complications in a large clinic-based cohort of type 1 diabetic patientsFrancesco Panero
Department of Internal Medicine, University of Turin, Turin, Italy
Diabetes Care 32:301-5. 2009..Our aim was to retrospectively evaluate the association of fasting plasma C-peptide values with micro- and macrovascular complications.
- Fasting insulin reflects heterogeneous physiological processes: role of insulin clearanceMark O Goodarzi
Cedars Sinai Medical Center, Division of Endocrinology, Diabetes and Metabolism, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA
Am J Physiol Endocrinol Metab 301:E402-8. 2011Several processes contribute to variation in fasting insulin concentration, including fasting glucose, insulin resistance, insulin secretion, and insulin clearance...
- GLP-1 based therapies: differential effects on fasting and postprandial glucoseM S Fineman
Elcelyx Therapeutics, Inc, San Diego, CA, USA
Diabetes Obes Metab 14:675-88. 2012..have differential effects on their mechanisms of action, ultimately resulting in differential effects on their fasting and postprandial glucose lowering potential...
- Evaluation of fasting state-/oral glucose tolerance test-derived measures of insulin release for the detection of genetically impaired β-cell functionSilke A Herzberg-Schäfer
Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, University Hospital Tübingen and Eberhard Karls University Tübingen, Tubingen, Germany
PLoS ONE 5:e14194. 2010To date, fasting state- and different oral glucose tolerance test (OGTT)-derived measures are used to estimate insulin release with reasonable effort in large human cohorts required, e.g., for genetic studies...
- Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivitySung Hee Um
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland
Nature 431:200-5. 2004..However, S6K1-deficient mice maintain normal glucose levels during fasting, suggesting hypersensitivity to insulin, raising the question of their metabolic fate as a function of age and ..
- Coexpression of Agrp and NPY in fasting-activated hypothalamic neuronsT M Hahn
Nat Neurosci 1:271-2. 1998
- Fasting activation of AgRP neurons requires NMDA receptors and involves spinogenesis and increased excitatory toneTiemin Liu
Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
Neuron 73:511-22. 2012..Activation of AgRP neurons by fasting, as assessed by c-Fos, Agrp and Npy mRNA expression, AMPA receptor-mediated EPSCs, depolarization and firing ..
- Gestational diabetes mellitus: simplifying the international association of diabetes and pregnancy diagnostic algorithm using fasting plasma glucoseMukesh M Agarwal
Department of Pathology, Faculty of Medicine, United Arab Emirates University, Al Ain, United Arab Emirates
Diabetes Care 33:2018-20. 2010..of Diabetes and Pregnancy Study Group (IADPSG) criteria on 1) gestational diabetes mellitus (GDM) diagnosis compared with the American Diabetes Association (ADA) criteria and 2) the fasting plasma glucose (FPG) to predict GDM.
- The loss of postprandial glycemic control precedes stepwise deterioration of fasting with worsening diabetesLouis Monnier
Department of Metabolic Diseases, Lapeyronie Hospital, 34295 Montpellier Cedex 5, France
Diabetes Care 30:263-9. 2007The aim of the study was to determine whether the loss of fasting and postprandial glycemic control occurs in parallel or sequentially in the evolution of type 2 diabetes.
- Effects of prandial versus fasting glycemia on cardiovascular outcomes in type 2 diabetes: the HEART2D trialItamar Raz
Internal Medicine, Hadassah Hospital, Jerusalem, Israel
Diabetes Care 32:381-6. 2009..HEART2D) is a multinational, randomized, controlled trial designed to compare the effects of prandial versus fasting glycemic control on risk for cardiovascular outcomes in patients with type 2 diabetes after acute myocardial ..
- Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapyLizzia Raffaghello
Andrus Gerontology Center, Department of Biological Sciences and Norris Cancer Center, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089 0191, USA
Proc Natl Acad Sci U S A 105:8215-20. 2008....
- Association of television viewing with fasting and 2-h postchallenge plasma glucose levels in adults without diagnosed diabetesDavid W Dunstan
International Diabetes Institute, Melbourne, Australia
Diabetes Care 30:516-22. 2007We examined the associations of television viewing time with fasting plasma glucose (FPG) and 2-h postchallenge plasma glucose (2-h PG) levels in Australian adults.
- Longitudinal study on pubertal insulin resistanceM I Goran
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
Diabetes 50:2444-50. 2001..mass was assessed by dual-energy X-ray absorptiometry, visceral fat was determined by computed tomography, and fasting blood was analyzed for hormone levels...
- Quantitative contributions of gluconeogenesis to glucose production during fasting in type 2 diabetes mellitusA Wajngot
Department of Endocrinology and Diabetology, Karolinska Hospital, Stockholm, Sweden
Metabolism 50:47-52. 2001..Production and the contribution of gluconeogenesis declined more in the diabetic subjects during the fast. The factors regulating these changes remain uncertain...
- Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetesRona J Strawbridge
Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden
Diabetes 60:2624-34. 2011..Studies of the insulin processing pathway could provide new insights about T2D pathophysiology...
- The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylaseThomas Gerken
Chemistry Research Laboratory and Oxford Centre for Integrative Systems Biology, University of Oxford, 12 Mansfield Road, Oxford, Oxon OX1 3TA, UK
Science 318:1469-72. 2007..nuclei governing energy balance, and that Fto mRNA levels in the arcuate nucleus are regulated by feeding and fasting. Studies can now be directed toward determining the physiologically relevant FTO substrate and how nucleic acid ..
- Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fastingS Kersten
Institut de Biologie Animale, Universite de Lausanne, CH 1015 Lausanne, Switzerland
J Clin Invest 103:1489-98. 1999..peroxisomal fatty acid oxidation, suggesting that PPARalpha may be involved in the transcriptional response to fasting. To investigate this possibility, PPARalpha-null mice were subjected to a high fat diet or to fasting, and their ..
- mTORC1 controls fasting-induced ketogenesis and its modulation by ageingShomit Sengupta
Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
Nature 468:1100-4. 2010..Here we show that mTORC1 controls ketogenesis in mice in response to fasting. We find that liver-specific loss of TSC1 (tuberous sclerosis 1), an mTORC1 inhibitor, leads to a fasting-..
- Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's diseaseVeerendra Kumar Madala Halagappa
Laboratory of Neurosciences, National Institute on Aging, Intramural Research Program, Baltimore, MD 21224, USA
Neurobiol Dis 26:212-20. 2007..the hypothesis that two different energy restriction regimens, 40% calorie restriction (CR) and intermittent fasting (IF) can protect against cognitive decline in the triple-transgenic mouse model of AD (3xTgAD mice)...
- A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disordersT C Leone
Center for Cardiovascular Research, Washington University School of Medicine, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 96:7473-8. 1999..proliferator-activated receptor alpha (PPARalpha), plays a pivotal role in the cellular metabolic response to fasting. Short-term starvation caused hepatic steatosis, myocardial lipid accumulation, and hypoglycemia, with an ..
- Prolonged fasting identifies skeletal muscle mitochondrial dysfunction as consequence rather than cause of human insulin resistanceJoris Hoeks
Department of Human Biology, School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
Diabetes 59:2117-25. 2010..dysfunction is secondary to the development of insulin resistance, we employed the unique model of prolonged fasting in humans...
- The circulating metabolic regulator FGF21 is induced by prolonged fasting and PPARalpha activation in manCecilia Gälman
Department of Endocrinology, Metabolism and Diabetes, Molecular Nutrition Unit, Karolinska Institutet, Karolinska University Hospital Huddinge, S 141 86 Stockholm, Sweden
Cell Metab 8:169-74. 2008FGF21 is a critical metabolic regulator, pivotal for fasting adaptation and directly regulated by PPARalpha in rodents. However, the physiological role of FGF21 in man is not yet defined and was investigated in our study...
- Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesisJames Rhee
Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 100:4012-7. 2003The liver plays several critical roles in the metabolic adaptation to fasting. We have shown previously that the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) is induced in ..
- The role of alpha-cell dysregulation in fasting and postprandial hyperglycemia in type 2 diabetes and therapeutic implicationsBeth Elaine Dunning
PharmaWrite, Princeton, New Jersey 08540, USA
Endocr Rev 28:253-83. 2007..The evidence that glucagon excess contributes to the development and maintenance of fasting hyperglycemia and that failure to suppress glucagon secretion contributes to postprandial hyperglycemia is then ..
- Nontraumatic fracture risk with diabetes mellitus and impaired fasting glucose in older white and black adults: the health, aging, and body composition studyElsa S Strotmeyer
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA
Arch Intern Med 165:1612-7. 2005..Diabetes mellitus (DM) and related complications may increase clinical fracture risk in older adults...
- Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1alpha in skeletal muscleOrsolya M Palacios
USDA ARS Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
Aging (Albany NY) 1:771-83. 2009..we find that SIRT3 protein levels in skeletal muscle are sensitive to diet, for SIRT3 expression increases by fasting and caloric restriction, yet it is decreased by high-fat diet...
- Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intakeR Michael Anson
Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
Proc Natl Acad Sci U S A 100:6216-20. 2003..We report that when C57BL6 mice are maintained on an intermittent fasting (alternate-day fasting) dietary-restriction regimen their overall food intake is not decreased and their body ..
- Calcium signaling through CaMKII regulates hepatic glucose production in fasting and obesityLale Ozcan
Department of Medicine, Columbia University, New York, NY 10032, USA
Cell Metab 15:739-51. 2012..activated in a calcium- and IP3R-dependent manner by cAMP and glucagon in primary hepatocytes and by glucagon and fasting in vivo...
- Green tea intake lowers fasting serum total and LDL cholesterol in adults: a meta-analysis of 14 randomized controlled trialsXin Xin Zheng
Key Laboratory for Clinical Cardiovascular Genetics and Sino German Laboratory for Molecular Medicine, Cardiovascular Institute, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing, China
Am J Clin Nutr 94:601-10. 2011..The effect of green tea beverage and green tea extract on lipid changes is controversial...
- Free fatty acids link metabolism and regulation of the insulin-sensitizing fibroblast growth factor-21Knut Mai
Department of Endocrinology, Diabetes and Nutrition, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
Diabetes 58:1532-8. 2009..FGF-21 has been suggested to be a peroxisome proliferator-activator receptor (PPAR) alpha-dependent regulator of fasting metabolism, we hypothesized that free fatty acids (FFAs), natural agonists of PPARalpha, might modify FGF-21 ..
- Post-fasting olfactory, transcriptional, and feeding responses in DrosophilaShelli F Farhadian
Laboratory of Neurogenetics and Behavior, The Rockefeller University, 1230 York Avenue, Box 63, New York, NY 10065, USA
Physiol Behav 105:544-53. 2012The sensation of hunger after a period of fasting and of satiety after eating is crucial to behavioral regulation of food intake, but the biological mechanisms regulating these sensations are incompletely understood...
- Gene expression profile change and associated physiological and pathological effects in mouse liver induced by fasting and refeedingFang Zhang
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
PLoS ONE 6:e27553. 2011..Biological process and pathway analysis showed that fasting mainly affected lipid and carboxylic acid metabolic processes in liver...
- Refeeding after fasting elicits insulin-dependent regulation of Per2 and Rev-erbα with shifts in the liver clockYu Tahara
Department of Physiology and Pharmacology, School of Advanced Science and Engineering, Waseda University, Tokyo, Japan
J Biol Rhythms 26:230-40. 2011..Our results indicate that an acute change of Per2 and Rev-erbα gene expression mediated by refeeding-induced insulin secretion is a critical step mediating the early phase of feeding-induced entrainment of the liver clock...
- Rapid development of fasting-induced hepatic lipidosis in the American mink (Neovison vison): effects of food deprivation and re-alimentation on body fat depots, tissue fatty acid profiles, hematology and endocrinologyKirsti Rouvinen-Watt
Department of Plant and Animal Sciences, Nova Scotia Agricultural College, Truro, NS, Canada
Lipids 45:111-28. 2010..This could be a key contributor to the pathophysiology of fatty liver disease in mink influencing disease progression...
- Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetesTing Lu
Department of Endocrinology, Xuhui District Central Hospital, Shanghai, China
Nutr Res 32:408-12. 2012..double-blinded clinical study to analyze the effect of cinnamon extract on glycosylated hemoglobin A(1c) and fasting blood glucose levels in Chinese patients with type 2 diabetes...
- α-lipoic acid can improve endothelial dysfunction in subjects with impaired fasting glucoseGuangda Xiang
Department of Endocrinology, Wuhan General Hospital of Guangzhou Command, Wuhan 430070, Hubei Province, PR China
Metabolism 60:480-5. 2011..studies showed that impairment of endothelium-dependent arterial dilation (EDAD) exists in subjects with impaired fasting glucose (IFG). The crucial mechanism of this endothelial dysfunction remains unclear...
- Impaired fasting glucose is associated with renal hyperfiltration in the general populationToralf Melsom
Department of Medical Biochemistry, University Hospital of North Norway, and the Department of Clinical Medicine, University of Tromsø, Tromsø, Norway
Diabetes Care 34:1546-51. 2011..We assessed whether impaired fasting glucose (IFG; 5.6-6...
- Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studiesJennifer A Nettleton
Division of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas Health Sciences Center, Houston, Houston, Texas, USA
Diabetes Care 33:2684-91. 2010..association studies (GWAS) have identified several single nucleotide polymorphisms (SNPs) associated with fasting glucose and insulin concentrations in individuals free of diabetes...
- Elevated fasting insulin predicts the future incidence of metabolic syndrome: a 5-year follow-up studyKi Chul C Sung
Division of Cardiology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea
Cardiovasc Diabetol 10:108. 2011..We aimed to assess whether the baseline insulin levels could predict the development of MS in a well characterised cohort of otherwise healthy adults who were followed over a five year period...
- Effects of 16 genetic variants on fasting glucose and type 2 diabetes in South Asians: ADCY5 and GLIS3 variants may predispose to type 2 diabetesSimon D Rees
College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom
PLoS ONE 6:e24710. 2011..of Glucose and Insulin related traits Consortium (MAGIC) recently identified 16 loci robustly associated with fasting glucose, some of which were also associated with type 2 diabetes...
- Impact of A1C screening criterion on the diagnosis of pre-diabetes among U.S. adultsDevin M Mann
Department of Medicine, Division of General Internal Medicine, Mount Sinai School of Medicine, New York, New York, USA
Diabetes Care 33:2190-5. 2010New clinical practice recommendations include A1C as an alternative to fasting glucose as a diagnostic test for identifying pre-diabetes. The impact of these new recommendations on the diagnosis of pre-diabetes is unknown.
- Fasting increases and satiation decreases olfactory detection for a neutral odor in ratsP Aimé
Laboratoire de Neurosciences Sensorielles, Comportement, Cognition, CNRS, UMR 5020, Universite Claude Bernard Lyon 1, 50 avenue Tony Garnier, 69366 Lyon Cedex 07, France
Behav Brain Res 179:258-64. 2007..Since these results were obtained using a neutral odor, we suggest that olfactory acuity increases during fasting, enabling animals to more easily detect both food and environmental odors such as those of predators...
- Fasting plasma glucose and HbA1c as risk factors for Type 2 diabetesKazuo Inoue
Department of Public Health, Graduate School Medicine, University of Tokyo, Tokyo, Japan
Diabet Med 25:1157-63. 2008We examined the value of combining fasting plasma glucose (FPG) and glycated haemoglobin (HbA(1c)) as a predictor of diabetes, using the new American Diabetes Association (ADA) criteria of FPG and lower cut-off point of HbA(1c).
- Upregulation of Ghrelin expression in the stomach upon fasting, insulin-induced hypoglycemia, and leptin administrationK Toshinai
Third Department of Internal Medicine, Miyazaki Medical College, Miyazaki, 889 1692, Japan
Biochem Biophys Res Commun 281:1220-5. 2001..in rat stomach, with the ratio of des-octanoylated ghrelin to n-octanoylated ghrelin markedly increased after fasting. The ghrelin mRNA level in the stomach also increased after administration of insulin and leptin...
- Perioperative fasting in adults and children: guidelines from the European Society of AnaesthesiologyIan Smith
Directorate of Anaesthesia, University Hospital of North Staffordshire, Stoke on Trent, UK
Eur J Anaesthesiol 28:556-69. 2011This guideline aims to provide an overview of the present knowledge on aspects of perioperative fasting with assessment of the quality of the evidence...
- Increased arterial stiffness in healthy subjects with high-normal glucose levels and in subjects with pre-diabetesJin Young Shin
Department of Family Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
Cardiovasc Diabetol 10:30. 2011Increased fasting plasma glucose (FPG), which includes impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and diabetes, is a risk factor for arterial stiffness...
- Fasting C-peptide levels and death resulting from all causes and breast cancer: the health, eating, activity, and lifestyle studyMelinda L Irwin
Yale School of Public Health, P O Box 208034, New Haven, CT 06520 8034, USA
J Clin Oncol 29:47-53. 2011..To examine the association between serum C-peptide, a marker of insulin secretion, measured 3 years after a breast cancer diagnosis, and death resulting from all causes and breast cancer...
- Desnutrin, an adipocyte gene encoding a novel patatin domain-containing protein, is induced by fasting and glucocorticoids: ectopic expression of desnutrin increases triglyceride hydrolysisJosep A Villena
Department of Nutritional Sciences and Toxicology, University of California, Berkeley, California 94720, USA
J Biol Chem 279:47066-75. 2004..Desnutrin mRNA levels were regulated by the nutritional status of animals, being transiently induced during fasting. In vitro desnutrin gene expression was up-regulated by dexamethasone in a dose-dependent manner but not by cAMP, ..
- Assessment of dietary consumption and time-course of changes in serum lipids and lipoproteins before, during and after Ramadan in young Algerian adultsM Y Lamri-Senhadji
Laboratoire de Nutrition Clinique et Métabolique, Faculte des Sciences, Department de Biologie, Université d Oran, 31100 Es Sénia, Algeria
Singapore Med J 50:288-94. 2009During the month of Ramadan, fasting is obligatory for all healthy adult Muslims, with the only exempted adults being those who have to travel or are sick...
- Pioglitazone decreases fasting and postprandial endogenous glucose production in proportion to decrease in hepatic triglyceride contentBalasubramanian Ravikumar
Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, U K
Diabetes 57:2288-95. 2008..We studied the effect of pioglitazone on hepatic triglyceride content and the consequent effect on postprandial endogenous glucose production (EGP) in type 2 diabetes...
- Beneficial effects of intermittent fasting and caloric restriction on the cardiovascular and cerebrovascular systemsMark P Mattson
Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
J Nutr Biochem 16:129-37. 2005Intermittent fasting (IF; reduced meal frequency) and caloric restriction (CR) extend lifespan and increase resistance to age-related diseases in rodents and monkeys and improve the health of overweight humans...
- Homeostasis model assessment is more reliable than the fasting glucose/insulin ratio and quantitative insulin sensitivity check index for assessing insulin resistance among obese children and adolescentsMehmet Keskin
Department of Pediatrics, School of Medicine, Erciyes University, 38039, Kayseri, Turkey
Pediatrics 115:e500-3. 2005Simple fasting methods to measure insulin resistance, such as the homeostasis model assessment (HOMA), fasting glucose/insulin ratio (FGIR), and quantitative insulin sensitivity check index (QUICKI) methods, have been widely promoted for ..
- Fasting blood glucose and cancer risk in a cohort of more than 140,000 adults in AustriaK Rapp
Department of Epidemiology, University of Ulm, Ulm, Germany
Diabetologia 49:945-52. 2006We investigated relations between fasting blood glucose and the incidence of cancer.
- An investigation into the acute and long-term effects of selected yogic postures on fasting and postprandial glycemia and insulinemia in healthy young subjectsS Manjunatha
Department of Physiology, All India Institute of Medical Sciences, New Delhi
Indian J Physiol Pharmacol 49:319-24. 2005..The study is significant in that it has for the first time attempted to probe the mechanism by which yogasanas help diabetes mellitus...
- Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target geneS Kersten
Institut de Biologie Animale, Universite de Lausanne, CH 1015, Switzerland
J Biol Chem 275:28488-93. 2000b>Fasting is associated with significant changes in nutrient metabolism, many of which are governed by transcription factors that regulate the expression of rate-limiting enzymes...
- Concurrent alterations of O-GlcNAcylation and phosphorylation of tau in mouse brains during fastingXu Li
Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, P R China
Eur J Neurosci 23:2078-86. 2006..regulates protein O-GlcNAcylation, and the latter modulates phosphorylation of tau inversely, we investigated, in fasting Kunming mice, whether impaired brain glucose uptake/metabolism causes abnormal hyperphosphorylation of tau and, ..
- Fasting compared with nonfasting triglycerides and risk of cardiovascular events in womenSandeep Bansal
Donald W Reynolds Center for Cardiovascular Research, Brigham and Women s Hospital, Boston, MA 02215, USA
JAMA 298:309-16. 2007..Although triglyceride levels are typically obtained in the fasting state, postprandial hypertriglyceridemia may play an important role in atherosclerosis.
- Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophyM D Gomes
Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 98:14440-5. 2001Muscle wasting is a debilitating consequence of fasting, inactivity, cancer, and other systemic diseases that results primarily from accelerated protein degradation by the ubiquitin-proteasome pathway...
- SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylationMatthew D Hirschey
Gladstone Institute of Virology and Immunology, San Francisco, California 94158, USA
Nature 464:121-5. 2010..Here we report that SIRT3 expression is upregulated during fasting in liver and brown adipose tissues...
- Defect in peroxisome proliferator-activated receptor alpha-inducible fatty acid oxidation determines the severity of hepatic steatosis in response to fastingT Hashimoto
Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611 3008, USA
J Biol Chem 275:28918-28. 2000b>Fasting causes lipolysis in adipose tissue leading to the release of large quantities of free fatty acids into circulation that reach the liver where they are metabolized to generate ketone bodies to serve as fuels for other tissues...
- CREB regulates hepatic gluconeogenesis through the coactivator PGC-1S Herzig
Peptide Biology Laboratories, Salk Institute for Biological Studies, 10010 N Torrey Pines Road, La Jolla, California 92037 1002, USA
Nature 413:179-83. 2001..response element binding (CREB) protein gene, or overexpressing a dominant-negative CREB inhibitor, exhibit fasting hypoglycaemia [corrected] and reduced expression of gluconeogenic enzymes...
- The transcriptomic signature of fasting murine liverMilka Sokolovic
AMC Liver Center, Academic Medical Center, University of Amsterdam, The Netherlands
BMC Genomics 9:528. 2008The contribution of individual organs to the whole-body adaptive response to fasting has not been established...
- Patient-directed titration for achieving glycaemic goals using a once-daily basal insulin analogue: an assessment of two different fasting plasma glucose targets - the TITRATE studyL Blonde
Ochsner Diabetes Clinical Research Unit, Department of Endocrinology, Diabetes and Metabolic Diseases, Ochsner Medical Center, New Orleans, LA, USA
Diabetes Obes Metab 11:623-31. 2009To compare efficacy and safety of two fasting plasma glucose (FPG) titration targets [4.4-6.1 mmol/l (80-110 mg/dl) and 3.9-5...
- Type 2 diabetes and impaired fasting blood glucose in rural Bangladesh: a population-based studyAkhtar Hussain
Institute of General Practice and Community Medicine, Department of International Health, University of Oslo, Norway
Eur J Public Health 17:291-6. 2007..Therefore, it is of particular interest to study the epidemiological transition of the state and to identify the risk factors in order to recognize the extent of the problem...
- Long-chain omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid dose-dependently reduce fasting serum triglyceridesKathy Musa-Veloso
Cantox Health Sciences International, Mississauga, Ontario, Canada
Nutr Rev 68:155-67. 2010..the long-chain omega-3 fatty acids eicosapentaenoic acid and/or docosahexaenoic acid dose-dependently reduce fasting serum triglycerides (TG) and, if so, to create a mathematical model that may be used to predict potential percent ..
- Pyruvate Dehydrogenase kinase as Therapeutic Target for Hepatic Steatosis, ObesitRobert A Harris; Fiscal Year: 2012..of the proposal are: (a) determine the effects that knocking out both PDK2 and PDK4 in the same mouse has upon fasting blood glucose levels, glucose tolerance, insulin sensitivity, hepatic steatosis, adiposity, branched chain amino ..
- Brain Activation responses in adolescents with genetic predisposition to obesitySusan Carnell; Fiscal Year: 2011..b>Fasting levels of gut hormones will be assessed during the physical...
- Pharmacogenetics of obesity and endocannabinergic modulation (POEM)Russell A Wilke; Fiscal Year: 2012..12 quantitative traits: body mass index (BMI), waist circumference, hip circumference, waist/hip ratio (WHR), fasting glucose, insulin, insulin/glucose ratio, homeostasis model assessment of insulin resistance (HOMA-IR), fasting ..
- The gastric X/A-like (ghrelin) cell: A peripheral regulator of food intakeNILS WG LAMBRECHT; Fiscal Year: 2012..2) Effect of fasting (24 hr food restriction) and re-feeding on (a) nesfatin-1/NUCB2 concentration and ghrelin/desacyl ghrelin (DAG) ..
- Autonomic, Endothelial, and Inflammatory Correlates of Sleep DurationMERCEDES RENEE CARNETHON; Fiscal Year: 2012..tumor necrosis factor-1, plasminogen activator inhibitor-1) and inflammation (C-reactive protein) measured in fasting blood...
- Regulation of thyroid hormone levels by central and peripheral pathwaysKRISTEN RACHEL VELLA; Fiscal Year: 2013..As I transition from postdoctoral fellow to Instructor, I look to target the specific neurons responsible for fasting-induced suppression of TH levels and use the results of this research to apply for extramural funding, such as an ..
- Role of Txnip in adapting fuel metabolism to nutritional stateSIMON HUI; Fiscal Year: 2013..TKO) mice become hypoglycemia, hypertriglycerdemia and hyperketonemia when fasted and cannot survive long-term fasting. Using tissue-specific Txnip knockout mice, we have identified that impaired mitochondrial oxidation in the ..
- Impact of the P479L Variant in CPT1A on Infant Mortality in AlaskaDavid M Koeller; Fiscal Year: 2011..CPT1A is the liver isoform of CPT1 and is required for ketogenesis during periods of fasting. Patients with severe forms of CPT1A deficiency can present with a wide variety of symptoms, including ..
- Response to and signals of caloric restriction and intermittent feeding regimensMARC KOPEL HELLERSTEIN; Fiscal Year: 2010..Our studies have shown that intermittent feeding (IF) regimens such as modifed alternate-day fasting (mADF) reproduce many of the benefits of true CR in mice, without weight loss or change in body composition...
- Neurobehavioral Correlates of Familial/genetic obesity risk in adolescentsSusan Carnell; Fiscal Year: 2013..b>Fasting levels of gut hormones will be assessed during the physical...
- METABOLIC SYNDROME AND PERIODONTITIS IN POSTMENOPAUSAL WOMENMichael J LaMonte; Fiscal Year: 2013..composition;questionnaires on lifestyle habits, oral hygiene and medical history;resting blood pressure;and a fasting blood sample meticulously collected, processed and frozen, that have had relevant biomarkers measured...
- Retinoid Metabolism and Alcohol Induced DiseaseWilliam S Blaner; Fiscal Year: 2010..the sole transport protein for retinol in the circulation, accounting for >95% of the retinoid present in the fasting circulation...
- VitC to Decrease Effects of Smoking in Pregnancy on Infant Lung Function-CCC-LeadCYNTHIA T MCEVOY; Fiscal Year: 2013..smoking and medication compliance, including urine cotinines levels, smoking questionnaires, pill counts and fasting plasma ascorbic acid levels...
- Osteocalcin and Metabolic Risk Factors. The Framingham StudyYi Hsiang Hsu; Fiscal Year: 2011..effects on both serum OC and metabolic risk factors (including waist circumference, systolic blood pressure, fasting triglycerides, fasting HDL cholesterol, fasting plasma glucose, fasting plasma insulin, adiponectin ..
- The Relationship Between STK39, Salt Sensitivity, and HCTZ-induced BP ResponseYEN PEI CHRISTY CHANG; Fiscal Year: 2010..Interestingly, the STK39 genotypes associated with higher BP are also associated with lower fasting glucose, raising the possibility that STK39 genotypes might predict a subgroup of salt-sensitive hypertensives ..
- JNK exacerbates ischemia/reperfusion injury in hyperglycemic subjects.Keith A Webster; Fiscal Year: 2010..PUBLIC HEALTH RELEVANCE: Fasting hyperglycemia is associated with increased myocardial infarction in both animal models and patients...
- Sex Hormones in Postmenopausal Women in the Diabetes Prevention ProgramCatherine Kim; Fiscal Year: 2012..The DPP enrolled participants with either impaired fasting glucose or impaired glucose tolerance, 45% of whom were non-white, and the DPP also obtained multiple measures of ..
- Early Life Conditions, Survival, and Health: A Pedigree-Based Population StudyKen R Smith; Fiscal Year: 2013..acid, creatinine, serum cholesterol, glycosylated hemoglobin, dehydroepiandrosterone sulfate (DHEAS &DHEA), fasting glucose and insulin resistance, telomere length, blood pressure, heart rate, grip strength, forced expiratory ..
- Role of leptin-mediated PI3 Kinase signaling on reproductive controlCarol Fuzeti Elias; Fiscal Year: 2013..Leptin also blunts the fasting-induced suppression of LH secretion and fertility...
- Atypical PKC Knockout Models: Effect on Glucose and Lipid HomeostasisRobert V Farese; Fiscal Year: 2013..protects lipid and glucose homeostasis by diminishing activation of hepatic SREBP-1c and NF B, and by diminishing fasting-dependent expression of PEPCK and glucose-6-phosphatase (G6Pase)...
- Undercarboxylated osteocalcin, body fat, and diabetes in older adultsAnn V Schwartz; Fiscal Year: 2010..those with and without diabetes, the study will also determine whether ucOC levels at baseline predict changes in fasting glucose, A1C and insulin resistance, in lipids (serum triglycerides, total cholesterol, LDLc, HDLc, nonHDLc, and ..
- Arsenic Exposure, Genetic Determinants and Diabetes Risk in a Family StudyAna Navas-Acien; Fiscal Year: 2013..Demographic, lifestyle and medical information and measures of fasting glucose and insulin, lipid profile, hypertension endpoints, body mass index, and waist and hip circumferences are ..
- A Culturally Tailored LIfestyle Intervention to Prevent Diabetes in South Asians:KABAYAM M VENKAT NARAYAN; Fiscal Year: 2010..Secondary outcomes are changes in percent body fat, body mass index, waist-to-hip ratio, fasting glucose, blood pressure, plasma lipids, activity, and diet...
- Hypothalamic SIRT1 and Energy BalanceEduardo A Nillni; Fiscal Year: 2013..availability to energy homeostasis at the hypothalamic level, and this effect depends -at least in part- on the fasting induced and Sirt1 mediated regulation of FoxO1 deacetylation and mTOR signaling...
- Effects of GSH +/- Arginine on Markers of Inflammation Among Adults with CVD RiskChristopher D Gardner; Fiscal Year: 2010..Secondary outcomes include blood pressure, blood cholesterol, fasting insulin, serum isoprostanes (a measure of oxidative stress) and s-nitrosyl glutathione (a stable, nitric oxide ..
- Exploring persistent epigenetic changes after prenatal famine exposure in humansL H Lumey; Fiscal Year: 2010..to disease risk factors for cardio-vascular disease and diabetes such as obesity, elevated blood cholesterol or fasting glucose values...
- VitC to Decrease Effects of Smoking in Pregnancy on Infant Lung Function-DCCCynthia D Morris; Fiscal Year: 2013..smoking and medication compliance, including urine cotinines levels, smoking questionnaires, pill counts and fasting plasma ascorbic acid levels...
- Regulation of Triglyceride Metabolism by the transcription factor CREB-HAnn Hwee Lee; Fiscal Year: 2013..CREB-H is induced by fatty acids, the fatty acid oxidation regulator PPAR1, and fasting in the liver, suggesting that it might participate in nutrient and energy metabolism...
- Comparative Effectiveness of Medical Therapy vs. Bariatric Surgery for Obese T2DMDAVID BRADLEY contact LAUTZ; Fiscal Year: 2010..endpoint of this 2-year feasibility study will be glycemic control 12 months after randomization, assessed as fasting plasma glucose levels <126 mg/dL and HbA1c <6.5%...
- Lifespan Extension Despite Greatly Elevated Insulin and Body FatDavid E Harrison; Fiscal Year: 2013..In vivo tests to identify this point will include short-term fasting glucose and insulin levels, glucose tolerance, insulin sensitivity, gluconeogenesis, glycogenolysis, beta-..
- NPC1L1 and Metabolic DiseasesLiqing Yu; Fiscal Year: 2013..at biochemical and gene expression levels in WT and L1KO mice under dietary excess, ezetimibe treatment or fasting conditions...
- Regulation of Hepatic Lipid and Glucose Metabolism by PC-TP/StarD2David E Cohen; Fiscal Year: 2013..Them2 limits insulin signaling and thereby promotes hepatic glucose production and triglyceride synthesis under fasting conditions...
- Hyperglycemia and Pregnancy Outcome(HAPO)Follow Up StudyBoyd E Metzger; Fiscal Year: 2013..and independently associated with later maternal risk of disorders of glucose metabolism (diabetes, impaired fasting glucose, impaired glucose tolerance)...
- Metabolic Actions of Omega-3 Fatty Acids on InflammationMichael Miller; Fiscal Year: 2013..3 of the following components: central obesity, high triglycerides, low HDL, abnormal blood pressure and impaired fasting glucose levels...
- Insulin Signaling and Metabolic Effects through CLK2 KinasePere Puigserver; Fiscal Year: 2013..the effects of Clk2 on hepatic glucose and lipid metabolism in mice through loss-of-function of hepatic Clk2 in fasting/feeding cycles and genetic and diet-induced obesity...
- Growth hormone and adult physiologyRhonda D Kineman; Fiscal Year: 2013..muscle) 3) determine if AOiGHD will influence whole body metabolism and weight changes in response to acute fasting/refeeding or longterm diet-induced weight loss...
- Novel PPAR-Independent Peroxisome Proliferators for Type 2 DiabetesLIDIA NIEROBISZ; Fiscal Year: 2011..The proof of principle compound reduces fasting blood glucose, decreases plasma free fatty acids and decreases lipid accumulation in the liver...
- Maternal Obesity and Gestational Diabetes: Impact on MetabolomeWilliam L Lowe; Fiscal Year: 2013..the hypothesis that distinct metabolic signatures are independently associated with maternal metabolic traits (fasting, 1 hr., and 2 hr...
- Energy Balance During Ketosis in Rat BrainJOSEPH CHARLES LAMANNA; Fiscal Year: 2010..fuel for brain, ketones supplement brain metabolism, especially under conditions of glucose sparing, such as fasting, starvation or high fat-low carbohydrate diet...
- The New England Family Study: Fifty Year Post-Perinatal Follow-Up for Life CourseERIC contact LOUCKS; Fiscal Year: 2010..assessments include adiposity, atherosclerosis (coronary artery calcium CT scans), cognitive function, diabetes (fasting glucose), and cardiovascular risk factors (e.g. lipids)...
- Mediators of Atherosclerosis in South Asians Living in AmericaAlka M Kanaya; Fiscal Year: 2013..Pakistan, Nepal, Bangladesh, and Sri Lanka) represent a quarter of the world's population and are one of the fasting growing ethnic groups in the United States...
- Role of the insulin/IGF-axis in incident CIN-2+Howard D Strickler; Fiscal Year: 2010..serum levels of IGF-I, IGF-II, IGFBP-3, and C-peptide (a surrogate marker of insulin that does not require fasting blood), in N=182 GP women with persistent oncogenic HPV, and N=142 with incident cervical pre-cancer (i.e...
- Melanin-Concentrating Hormone: Ancestral Role in Feeding &Sleep RegulationPhilippe Mourrain; Fiscal Year: 2013..MCH2, like mammalian hMCH, is expressed in a distinct population of hypothalamic neurons and is up-regulated upon fasting, suggesting a conservation of MCH2/hMCH regulation and function across vertebrates...
- Pulmonary Vascular-Right Ventricular Axis Research ProgramWai Hong Wilson Tang; Fiscal Year: 2013..expression and uptake of the glucose analogue [18F]2-fluoro-2-deoxy-D-glucose by positron emission tomography (fasting FDG-PET) in PAH patients...
- SIRT1 as a regulator of health and lifespan of mammalsDavid A Sinclair; Fiscal Year: 2013..reactive oxygen species (ROS) and lactate, and a failure of muscle mitochondria to adapt their metabolism to fasting. Strikingly, this same defect occurs in wild type mice as they age...
- Cellular Mechanisms for Increased Gluconeogenesis in Type 2 DiabetesVarman T Samuel; Fiscal Year: 2013DESCRIPTION (provided by applicant): In patients with T2D, increased hepatic gluconeogenesis is the main cause of fasting hyperglycemia...
- Classical and non-classical responses to vitamin D in children: the role of DBP gThomas O Carpenter; Fiscal Year: 2010..changes in BMI, incidence of infection, blood pressure, insulin sensitivity (using measures derived from fasting insulin and cortisol levels) and circulating levels of aldosterone and renin...
- Vitamin D and Vascular Function in Obese ChildrenKumaravel Rajakumar; Fiscal Year: 2013..pulse wave velocity as a measure of arterial stiffness;(3) surrogate estimates of insulin sensitivity (fasting glucose/fasting insulin ratio or Homeostasis Model of Assessment - Insulin Resistance [HOMA-IR]);(4) metabolic ..
- Establishing the Precursors of Osteoporosis in ChildrenXiping Xu; Fiscal Year: 2010..the funded MS study, including steroid hormones: androgen, estrogen, testosterons, LH, and FSH;metabolic markers: fasting and 2-hr post OGTT insulin, glucose, HOMA-IR, fasting lipids;growth hormones: insulin-like growth factor (IGF-I);..
- Appetite-regulating Hormones and Neurocircuitry in Anorexia NervosaELIZABETH AUSTEN LAWSON; Fiscal Year: 2013..During a single visit, subjects will undergo measurement of BMI;a fasting blood draw for hormone levels (eg, ghrelin, PYY);assessment of appetite, mood and disordered eating ..
- RISK FACTORS FOR CVD IN WOMENJOANN ELISABETH MANSON; Fiscal Year: 2012..Blood samples were collected from 32,826 participants in 1989-1990 (with 18,664 fasting), and detailed nutritional, behavioral, and lifestyle variables have been collected biennially...
- Biopsychosocial Determinants of Adolescent Obesity/Cardiovascular RiskSheila Gahagan; Fiscal Year: 2012..In addition, we will measure anthropometry, fat and muscle mass (DXA), fasting glucose, insulin (HOMA IR), lipids, leptin, ghrelin, adiponectin, orexin, CRP, and TNF alpha...
- Systemic Factors that Maintain a Young Liver PhenotypeRoy G Smith; Fiscal Year: 2012..During CR and fasting, production of the hormone ghrelin increases and the ghrelin receptor (GHS-R1a) expressed in the hypothalamus is ..
- Renin-angiotensin and fibrinolysis interaction in humansNANCY JOAN BROWN; Fiscal Year: 2013..An effect of ACE inhibition on incident diabetes was not replicated in patients with impaired fasting glucose in the Diabetes Reduction Assessment with Ramipril and Rosiglitazone Medication trial...
- Metabolic Syndrome and PeriodontitisELIZABETH A KAYE; Fiscal Year: 2013..Serum lipids, fasting serum glucose, body mass index and waist circumference were also measured every 3 years over the same time period...
- CONTROL OF GONADOTROPIN SECRETION DURING LACTATIONKevin L Grove; Fiscal Year: 2013DESCRIPTION (provided by applicant): It is firmly established that states of energy deficiency, such as fasting, anorexia nervosa, cachexia, bulimia, lactation and exercise-induced amenorrhea, as well as states of energy overabundance, ..
- Structure and Function of Enzymes in Fatty Acid OxidationJUNG JA P KIM; Fiscal Year: 2013..The rate of this process can be altered by diet (fed/fasting), physiological status (pregnancy), or diseases (diabetes)...
- Regulation of Hepatic Gluconeogenesis by the CREB:TORC2 PathwayMarc R Montminy; Fiscal Year: 2010During fasting, elevations in circulating pancreatic glucagon promote hepatic glucose output through induction of the gluconeogenic program by the CREB coactivator TORC2...
- Lactation and Incidence of Diabetes Mellitus in CARDIA WomenERICA PAULINE GUNDERSON; Fiscal Year: 2013..Entering its 25th year, CARDIA will have measured cardiometabolic risk factors (fasting glucose, insulin, lipids, BMI, waist girth, blood pressure) up to 8 times since baseline (1986-2011), and ..
- Regulation of Hepatic Gluconeogenesis by the CREB:TORC2 PathwayMarc R Montminy; Fiscal Year: 2013During fasting, elevations in circulating pancreatic glucagon promote hepatic glucose output through induction of the gluconeogenic program by the CREB coactivator TORC2...
- A simple dietary message to improve dietary quality for metabolic syndromeYunsheng Ma; Fiscal Year: 2012..Assessments, including diet, anthropometrics, blood pressure, fasting blood glucose, glycosylated hemoglobin (HbA1c), blood lipids, insulin, inflammatory markers, medication use, ..
- A Mindfulness-Based Approach to the Treatment of Obesity and DiabetesCarla K Miller; Fiscal Year: 2010..The impact of the interventions on weight, glycemic control (HbA1c and fasting plasma glucose), insulin sensitivity, dietary intake, physical activity, depression, anxiety and self-efficacy ..
- Regulation of Carbohydrate Metabolism and LipogenesisKosaku Uyeda; Fiscal Year: 2013..of ChREBP enhances the binding to 14-3-3 and is essential for export of ChREBP out of the nucleus under fasting conditions...
- GASTROINTESTINAL & CARDIAC RESPONSE TO SEMI-STARVATIONEleanor Young; Fiscal Year: 1991..overcome the adverse effects of negative N balance and subsequent loss of lean muscle mass that occurs with total fasting. The safety and efficacy of these diets were strongly challenged following reports of adverse effects and of ..
- NEUROENDOCRINE CONTROL OF ANTERIOR PITUITARY HORMONESRHONDA KINEMAN; Fiscal Year: 2006..To test this hypothesis, the effects of fasting on neuropeptide mRNA levels, in mice harboring defects in leptin synthesis (ob/ob), tissue source of leptin (AZIP-..
- DIETARY COMPOSITION, OBESITY, AND CARDIOVASCULAR RISKERNST SCHAEFER; Fiscal Year: 2003..C, HDL C, remnant lipoprotein C, Lp(a) C, insulin, glycosylated hemoglobin, glucose, and blood pressure) in the fasting and nonfasting state (4 hours after a meal) in 80 men and women (men greater than or equal to 50 and less than 65 ..
- CORONARY ARTERY DISEASE AND POSTPRANDIAL LIPOPROTEINSHenry Ginsberg; Fiscal Year: 1992Epidemiologic evidence for an association between risk for developing CAD and fasting levels of plasma lipids, lipoproteins and apolipoproteins is derived from international cross-sectional data, prospective within-country population ..
- Role of GLP-1 in Congenital HyperinsulinismDIVA DEL CARMEN DE LEON; Fiscal Year: 2010..mice) and that antagonism of the GLP-1 receptor by exendin-(9-39) suppresses insulin secretion and corrects fasting hypoglycemia in these mice...
- Endothelial Function Predictors in Adolescent DiabetesROBERT PAUL HOFFMAN; Fiscal Year: 2010..Unfortunately, most studies that have examined endothelial function in type 1 diabetes have done so in the usual fasting state. It is unknown what effect short-term glucose control and acute glucose level have on these measurements...
- TRH REGULATION/BIOSYNTHESIS AND PARAVENTRICULAR NUCLEUSRONALD MICHAEL LECHAN; Fiscal Year: 2010..hormone under normal conditions and during special circumstances when metabolic adaptation is necessary such as fasting, infection and chronic illnesses...
- A Pilot of Customized Continuous Care Management of Obesity in Pre-DiabeticsJun Ma; Fiscal Year: 2010..a Customized Continuous Care Management (CCCM) model with patients who are obese or overweight and have impaired fasting glucose in a primary care setting...
- Hyperhomocysteinemia in Alzheimer's DiseaseRamon Diaz Arrastia; Fiscal Year: 2003..We plan to do this through the following specific aims: (a) Determine whether fasting or post-methionine load (PML) are best associated with AD...
- Molecular Epidemiology of Recurrent Aphthous Stomatitis: Role of GhrelinLorena Baccaglini; Fiscal Year: 2009..Specific Aim 1 (Circulating ghrelin): We will compare fasting total plasma ghrelin levels (1) in 60 cases (30 with and 30 without active ulcers) vs...
- Role of Oleylethanolamine in the Regulation of the HPT AxisCsaba Fekete; Fiscal Year: 2010..anorexic actions, oleylethanolamine (OEA), in the regulation of the hypothalamic-pituitary-thyroid axis during fasting. Since we observed in our preliminary studies that OEA inhibits the fasting-induced activation of cfos in NPY ..