fasting

Summary

Summary: Abstaining from all food.

Top Publications

  1. ncbi Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
    D R Matthews
    Diabetologia 28:412-9. 1985
  2. doi National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants
    Goodarz Danaei
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Lancet 378:31-40. 2011
  3. ncbi The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism
    Seung Hoi Koo
    Peptide Biology Laboratories, Salk Institute for Biological Studies, 10010 N Torrey Pines Rd, La Jolla, California 92037 1002, USA
    Nature 437:1109-11. 2005
  4. ncbi Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21
    Takeshi Inagaki
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Metab 5:415-25. 2007
  5. ncbi Impaired glucose tolerance and impaired fasting glycaemia: the current status on definition and intervention
    N Unwin
    Diabetes and Metabolism, School of Clinical Medical Sciences, University of New Castle, UK
    Diabet Med 19:708-23. 2002
  6. pmc Trajectories of glycaemia, insulin sensitivity, and insulin secretion before diagnosis of type 2 diabetes: an analysis from the Whitehall II study
    Adam G Tabak
    Department of Epidemiology and Public Health, University College London, London, UK
    Lancet 373:2215-21. 2009
  7. ncbi Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
    J C Yoon
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 413:131-8. 2001
  8. ncbi Reduced postprandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patients
    T Vilsbøll
    Department of Internal Medicine F, Gentofte Hospital, University of Copenhagen, Denmark
    Diabetes 50:609-13. 2001
  9. pmc The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver
    Nicola L Beer
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK
    Hum Mol Genet 18:4081-8. 2009
  10. doi Adipocytes in subjects with impaired fasting glucose and impaired glucose tolerance are resistant to the anti-lipolytic effect of insulin
    Muhammad A Abdul-Ghani
    Diabetes Division, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Acta Diabetol 45:147-50. 2008

Detail Information

Publications364 found, 100 shown here

  1. ncbi Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
    D R Matthews
    Diabetologia 28:412-9. 1985
    ..Comparison of a patient's fasting values with the model's predictions allows a quantitative assessment of the contributions of insulin resistance ..
  2. doi National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants
    Goodarz Danaei
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Lancet 378:31-40. 2011
    ..We estimated trends and their uncertainties in mean fasting plasma glucose (FPG) and diabetes prevalence for adults aged 25 years and older in 199 countries and territories.
  3. ncbi The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism
    Seung Hoi Koo
    Peptide Biology Laboratories, Salk Institute for Biological Studies, 10010 N Torrey Pines Rd, La Jolla, California 92037 1002, USA
    Nature 437:1109-11. 2005
    ..Glucagon enhances glucose output from the liver during fasting by stimulating the transcription of gluconeogenic genes via the cyclic AMP-inducible factor CREB (CRE binding ..
  4. ncbi Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21
    Takeshi Inagaki
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Metab 5:415-25. 2007
    ..FGF21 is induced directly by PPARalpha in liver in response to fasting and PPARalpha agonists. FGF21 in turn stimulates lipolysis in white adipose tissue and ketogenesis in liver...
  5. ncbi Impaired glucose tolerance and impaired fasting glycaemia: the current status on definition and intervention
    N Unwin
    Diabetes and Metabolism, School of Clinical Medical Sciences, University of New Castle, UK
    Diabet Med 19:708-23. 2002
    ..review the latest information relating to the risks associated with impaired glucose tolerance (IGT) and impaired fasting glycaemia (IFG) for future diabetes and cardiovascular disease (CVD)...
  6. pmc Trajectories of glycaemia, insulin sensitivity, and insulin secretion before diagnosis of type 2 diabetes: an analysis from the Whitehall II study
    Adam G Tabak
    Department of Epidemiology and Public Health, University College London, London, UK
    Lancet 373:2215-21. 2009
    ..We aimed to characterise trajectories of fasting and postload glucose, insulin sensitivity, and insulin secretion in individuals who develop type 2 diabetes.
  7. ncbi Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
    J C Yoon
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 413:131-8. 2001
    ..Gluconeogenesis is strongly stimulated during fasting and is aberrantly activated in diabetes mellitus...
  8. ncbi Reduced postprandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patients
    T Vilsbøll
    Department of Internal Medicine F, Gentofte Hospital, University of Copenhagen, Denmark
    Diabetes 50:609-13. 2001
    ..2% [7.0-12.5]) and 12 matched healthy subjects. The patients had fasting hyperglycemia (10.7 mmol/l [8.0-14.8]) increasing to 14.6 mmol/l (11.5-21.5) 75 min after meal ingestion...
  9. pmc The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver
    Nicola L Beer
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK
    Hum Mol Genet 18:4081-8. 2009
    ..A common GCKR variant (P446L) is reproducibly associated with triglyceride and fasting plasma glucose levels in the general population...
  10. doi Adipocytes in subjects with impaired fasting glucose and impaired glucose tolerance are resistant to the anti-lipolytic effect of insulin
    Muhammad A Abdul-Ghani
    Diabetes Division, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Acta Diabetol 45:147-50. 2008
    Impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) are two intermediate states in the transition from normal glucose metabolism to type 2 diabetes...
  11. pmc New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
    Josee Dupuis
    Department of Biostatistics, Boston University School of Public Health, Massachusetts, USA
    Nat Genet 42:105-16. 2010
    ..influencing glycemic traits, we performed meta-analyses of 21 genome-wide association studies informative for fasting glucose, fasting insulin and indices of beta-cell function (HOMA-B) and insulin resistance (HOMA-IR) in up to 46,..
  12. ncbi Contributions of fasting and postprandial plasma glucose increments to the overall diurnal hyperglycemia of type 2 diabetic patients: variations with increasing levels of HbA(1c)
    Louis Monnier
    Department of Metabolism, Lapeyronie Hospital, Montpellier, France
    Diabetes Care 26:881-5. 2003
    The exact contributions of postprandial and fasting glucose increments to overall hyperglycemia remain controversial. The discrepancies between the data published previously might be caused by the interference of several factors...
  13. doi Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans
    Sakiko Honjoh
    Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Sakyo ku, Kyoto, 606 8502, Japan
    Nature 457:726-30. 2009
    ..In mammals, two regimens of dietary restriction, intermittent fasting (IF) and chronic caloric restriction, have proven to extend lifespan and reduce the incidence of age-related ..
  14. doi The effect of time-of-day and Ramadan fasting on anaerobic performances
    H Chtourou
    Research Laboratory Sports Performance Optimization, National Center of Medicine and Science in Sports CNMSS, Tunis, Tunisia
    Int J Sports Med 33:142-7. 2012
    This study was designed to assess the effects of Ramadan-intermittent-fasting (RIF) and time-of-day on muscle power and fatigue during the Wingate test...
  15. ncbi Serum uric acid and risk for development of hypertension and impaired fasting glucose or Type II diabetes in Japanese male office workers
    N Nakanishi
    Department of Social and Environmental Medicine, Course of Social Medicine, Osaka University Graduate School of Medicine F2, Suita Shi, Osaka, Japan
    Eur J Epidemiol 18:523-30. 2003
    ..of hypertension (blood pressure > or = 140/90 mmHg and/or medication for hypertension) and impaired fasting glucose (IFG) (a fasting plasma glucose level 6.1-6...
  16. ncbi The metabolic syndrome as predictor of type 2 diabetes: the San Antonio heart study
    Carlos Lorenzo
    Division of Clinical Epidemiology, University of Texas Health Science Center, San Antonio, Texas 78284 7873, USA
    Diabetes Care 26:3153-9. 2003
    ....
  17. ncbi Fasting serum glucose level and cancer risk in Korean men and women
    Sun Ha Jee
    Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea
    JAMA 293:194-202. 2005
    ..Diabetes is a serious and costly disease that is becoming increasingly common in many countries. The role of diabetes as a cancer risk factor remains unclear...
  18. doi Identifying sources of phthalate exposure with human biomonitoring: results of a 48h fasting study with urine collection and personal activity patterns
    Holger M Koch
    Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum IPA, Burkle de la Camp Platz 1, 44789 Bochum, Germany Electronic address
    Int J Hyg Environ Health 216:672-81. 2013
    ..Therefore, we studied urinary phthalate metabolite patterns over a period of strict fasting and additionally recorded personal activity patterns with a diary to investigate non-dietary routes of exposure...
  19. pmc Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP
    Amy K Walker
    Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts 02129, USA
    Genes Dev 24:1403-17. 2010
    ..During fasting, SREBP-dependent lipid/cholesterol synthesis is rapidly diminished in the mouse liver; however, the mechanism has ..
  20. doi Pancreatic fat is negatively associated with insulin secretion in individuals with impaired fasting glucose and/or impaired glucose tolerance: a nuclear magnetic resonance study
    Martin Heni
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany
    Diabetes Metab Res Rev 26:200-5. 2010
    ..The aim was to thoroughly quantify the fat content of pancreas sections (caput, corpus, and cauda) and to compare the impact of pancreatic, intrahepatic, and visceral fat on insulin secretion in humans...
  21. doi Plasma osteocalcin is inversely related to fat mass and plasma glucose in elderly Swedish men
    Jenny M Kindblom
    Center for Bone Research at the Sahlgrenska Academy, Institute of Medicine, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    J Bone Miner Res 24:785-91. 2009
    ..b>Fasting levels of plasma osteocalcin, plasma glucose, serum insulin, and lipids were analyzed in elderly men (75.3 +/- 3...
  22. ncbi Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss
    D E Kelley
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Am J Physiol 277:E1130-41. 1999
    ..extraction of [9,10 (3)H]oleate) and indirect calorimetry across the leg to determine substrate oxidation during fasting and insulin-stimulated conditions...
  23. pmc Replication of genome-wide association studies (GWAS) loci for fasting plasma glucose in African-Americans
    E Ramos
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, MSC 5635, Bethesda, MD 20892, USA
    Diabetologia 54:783-8. 2011
    ..have significantly enhanced our understanding of the genetic basis of diabetes and related traits, including fasting plasma glucose (FPG). However, the majority of GWASs have been conducted in populations of European ancestry...
  24. pmc Prevalence of diabetes and impaired fasting glucose in Chinese adults, China National Nutrition and Health Survey, 2002
    Shuqian Liu
    College of Public Health, University of Oklahoma, Oklahoma City, Oklahoma, USA
    Prev Chronic Dis 8:A13. 2011
    ..We report the prevalence of type 2 diabetes and impaired fasting glucose (IFG) and the association between diabetes and overweight and obesity in Chinese adults...
  25. pmc Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle
    Carles Canto
    Ecole Polytechnique Federale de Lausanne, Switzerland
    Cell Metab 11:213-9. 2010
    During fasting and after exercise, skeletal muscle efficiently switches from carbohydrate to lipid as the main energy source to preserve glycogen stores and blood glucose levels for glucose-dependent tissues...
  26. pmc Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice
    Julio E Ayala
    Vanderbilt NIH Mouse Metabolic Phenotyping Center, Nashville, TN 37232, USA
    Dis Model Mech 3:525-34. 2010
    ..We also propose guidelines for the description of methods, presentation of data and interpretation of results. The recommendations presented in this article are based on the experience of the MMPC Consortium and other investigators...
  27. ncbi Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes
    Christian Wolfrum
    Laboratory of Metabolic Diseases, Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nature 432:1027-32. 2004
    ..Pharmacological intervention to inhibit phosphorylation of Foxa2 may be an effective treatment for type 2 diabetes...
  28. pmc Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: stimulation of eating by 2-arachidonoyl glycerol
    Tim C Kirkham
    Department of Psychology, University of Reading, Earley Gate, Whiteknights, Reading RG6 6AL, UK
    Br J Pharmacol 136:550-7. 2002
    ..measured anandamide and 2-arachidonoyl glycerol (2-AG) levels in feeding-associated brain regions of rats, during fasting, feeding of a palatable food, or after satiation...
  29. pmc The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis
    Yiguo Wang
    Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 460:534-7. 2009
    ..Here we show that CRTC2 functions as a dual sensor for ER stress and fasting signals...
  30. pmc Fasting and differential chemotherapy protection in patients
    Lizzia Raffaghello
    Andrus Gerontology Center, Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA
    Cell Cycle 9:4474-6. 2010
    ..Based on the discovery in model organisms that short term starvation (STS or fasting) causes a rapid switch of cells to a protected mode, we described a fasting-based intervention that causes ..
  31. pmc Effects of APOA5 -1131T>C (rs662799) on fasting plasma lipids and risk of metabolic syndrome: evidence from a case-control study in China and a meta-analysis
    Chunxiao Xu
    Department of Epidemiology and Biostatistics, School of Public Health, Zhejiang University, Hangzhou, Zhejiang, PR China
    PLoS ONE 8:e56216. 2013
    ..To systematically evaluate the associations between -1131T>C polymorphism and fasting lipid parameters and the risk of MetS, we conducted a case-control study in a Chinese population and a meta-..
  32. ncbi Fasting time and lipid levels in a community-based population: a cross-sectional study
    Davinder Sidhu
    Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada
    Arch Intern Med 172:1707-10. 2012
    Although current guidelines recommend measuring lipid levels in a fasting state, recent studies suggest that nonfasting lipid profiles change minimally in response to food intake and may be superior to fasting levels in predicting ..
  33. ncbi Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1
    Joseph T Rodgers
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 434:113-8. 2005
    ..modulates ageing in several species--controls the gluconeogenic/glycolytic pathways in liver in response to fasting signals through the transcriptional coactivator PGC-1alpha...
  34. pmc Inhibition of growth hormone signaling by the fasting-induced hormone FGF21
    Takeshi Inagaki
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Metab 8:77-83. 2008
    ..In this report, we demonstrate that fibroblast growth factor 21 (FGF21), a hormone induced by fasting, causes GH resistance...
  35. pmc Paradoxical regulation of human FGF21 by both fasting and feeding signals: is FGF21 a nutritional adaptation factor?
    Takashi Uebanso
    Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan
    PLoS ONE 6:e22976. 2011
    ..A deletion study of the human FGF21 promoter (-1672 to +230 bp) revealed two fasting signals, including peroxisome proliferator-activated receptor α (PPARα) and glucagon signals, that ..
  36. ncbi Urinary cadmium, impaired fasting glucose, and diabetes in the NHANES III
    Gary G Schwartz
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Diabetes Care 26:468-70. 2003
    ..To test the hypothesis that exposure to cadmium is associated with impaired fasting glucose and type 2 diabetes, we examined the associations between urinary cadmium and the prevalence of impaired ..
  37. pmc Fasting plasma C-peptide and micro- and macrovascular complications in a large clinic-based cohort of type 1 diabetic patients
    Francesco Panero
    Department of Internal Medicine, University of Turin, Turin, Italy
    Diabetes Care 32:301-5. 2009
    ..Our aim was to retrospectively evaluate the association of fasting plasma C-peptide values with micro- and macrovascular complications.
  38. pmc Fasting insulin reflects heterogeneous physiological processes: role of insulin clearance
    Mark O Goodarzi
    Cedars Sinai Medical Center, Division of Endocrinology, Diabetes and Metabolism, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA
    Am J Physiol Endocrinol Metab 301:E402-8. 2011
    Several processes contribute to variation in fasting insulin concentration, including fasting glucose, insulin resistance, insulin secretion, and insulin clearance...
  39. doi GLP-1 based therapies: differential effects on fasting and postprandial glucose
    M S Fineman
    Elcelyx Therapeutics, Inc, San Diego, CA, USA
    Diabetes Obes Metab 14:675-88. 2012
    ..have differential effects on their mechanisms of action, ultimately resulting in differential effects on their fasting and postprandial glucose lowering potential...
  40. pmc Evaluation of fasting state-/oral glucose tolerance test-derived measures of insulin release for the detection of genetically impaired β-cell function
    Silke A Herzberg-Schäfer
    Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, University Hospital Tübingen and Eberhard Karls University Tübingen, Tubingen, Germany
    PLoS ONE 5:e14194. 2010
    To date, fasting state- and different oral glucose tolerance test (OGTT)-derived measures are used to estimate insulin release with reasonable effort in large human cohorts required, e.g., for genetic studies...
  41. ncbi Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
    Sung Hee Um
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland
    Nature 431:200-5. 2004
    ..However, S6K1-deficient mice maintain normal glucose levels during fasting, suggesting hypersensitivity to insulin, raising the question of their metabolic fate as a function of age and ..
  42. ncbi Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons
    T M Hahn
    Nat Neurosci 1:271-2. 1998
  43. pmc Fasting activation of AgRP neurons requires NMDA receptors and involves spinogenesis and increased excitatory tone
    Tiemin Liu
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    Neuron 73:511-22. 2012
    ..Activation of AgRP neurons by fasting, as assessed by c-Fos, Agrp and Npy mRNA expression, AMPA receptor-mediated EPSCs, depolarization and firing ..
  44. pmc Gestational diabetes mellitus: simplifying the international association of diabetes and pregnancy diagnostic algorithm using fasting plasma glucose
    Mukesh M Agarwal
    Department of Pathology, Faculty of Medicine, United Arab Emirates University, Al Ain, United Arab Emirates
    Diabetes Care 33:2018-20. 2010
    ..of Diabetes and Pregnancy Study Group (IADPSG) criteria on 1) gestational diabetes mellitus (GDM) diagnosis compared with the American Diabetes Association (ADA) criteria and 2) the fasting plasma glucose (FPG) to predict GDM.
  45. ncbi The loss of postprandial glycemic control precedes stepwise deterioration of fasting with worsening diabetes
    Louis Monnier
    Department of Metabolic Diseases, Lapeyronie Hospital, 34295 Montpellier Cedex 5, France
    Diabetes Care 30:263-9. 2007
    The aim of the study was to determine whether the loss of fasting and postprandial glycemic control occurs in parallel or sequentially in the evolution of type 2 diabetes.
  46. pmc Effects of prandial versus fasting glycemia on cardiovascular outcomes in type 2 diabetes: the HEART2D trial
    Itamar Raz
    Internal Medicine, Hadassah Hospital, Jerusalem, Israel
    Diabetes Care 32:381-6. 2009
    ..HEART2D) is a multinational, randomized, controlled trial designed to compare the effects of prandial versus fasting glycemic control on risk for cardiovascular outcomes in patients with type 2 diabetes after acute myocardial ..
  47. pmc Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy
    Lizzia Raffaghello
    Andrus Gerontology Center, Department of Biological Sciences and Norris Cancer Center, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089 0191, USA
    Proc Natl Acad Sci U S A 105:8215-20. 2008
    ....
  48. ncbi Association of television viewing with fasting and 2-h postchallenge plasma glucose levels in adults without diagnosed diabetes
    David W Dunstan
    International Diabetes Institute, Melbourne, Australia
    Diabetes Care 30:516-22. 2007
    We examined the associations of television viewing time with fasting plasma glucose (FPG) and 2-h postchallenge plasma glucose (2-h PG) levels in Australian adults.
  49. ncbi Longitudinal study on pubertal insulin resistance
    M I Goran
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Diabetes 50:2444-50. 2001
    ..mass was assessed by dual-energy X-ray absorptiometry, visceral fat was determined by computed tomography, and fasting blood was analyzed for hormone levels...
  50. ncbi Quantitative contributions of gluconeogenesis to glucose production during fasting in type 2 diabetes mellitus
    A Wajngot
    Department of Endocrinology and Diabetology, Karolinska Hospital, Stockholm, Sweden
    Metabolism 50:47-52. 2001
    ..Production and the contribution of gluconeogenesis declined more in the diabetic subjects during the fast. The factors regulating these changes remain uncertain...
  51. pmc Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes
    Rona J Strawbridge
    Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden
    Diabetes 60:2624-34. 2011
    ..Studies of the insulin processing pathway could provide new insights about T2D pathophysiology...
  52. pmc The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase
    Thomas Gerken
    Chemistry Research Laboratory and Oxford Centre for Integrative Systems Biology, University of Oxford, 12 Mansfield Road, Oxford, Oxon OX1 3TA, UK
    Science 318:1469-72. 2007
    ..nuclei governing energy balance, and that Fto mRNA levels in the arcuate nucleus are regulated by feeding and fasting. Studies can now be directed toward determining the physiologically relevant FTO substrate and how nucleic acid ..
  53. pmc Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting
    S Kersten
    Institut de Biologie Animale, Universite de Lausanne, CH 1015 Lausanne, Switzerland
    J Clin Invest 103:1489-98. 1999
    ..peroxisomal fatty acid oxidation, suggesting that PPARalpha may be involved in the transcriptional response to fasting. To investigate this possibility, PPARalpha-null mice were subjected to a high fat diet or to fasting, and their ..
  54. doi mTORC1 controls fasting-induced ketogenesis and its modulation by ageing
    Shomit Sengupta
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 468:1100-4. 2010
    ..Here we show that mTORC1 controls ketogenesis in mice in response to fasting. We find that liver-specific loss of TSC1 (tuberous sclerosis 1), an mTORC1 inhibitor, leads to a fasting-..
  55. ncbi Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease
    Veerendra Kumar Madala Halagappa
    Laboratory of Neurosciences, National Institute on Aging, Intramural Research Program, Baltimore, MD 21224, USA
    Neurobiol Dis 26:212-20. 2007
    ..the hypothesis that two different energy restriction regimens, 40% calorie restriction (CR) and intermittent fasting (IF) can protect against cognitive decline in the triple-transgenic mouse model of AD (3xTgAD mice)...
  56. pmc A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders
    T C Leone
    Center for Cardiovascular Research, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 96:7473-8. 1999
    ..proliferator-activated receptor alpha (PPARalpha), plays a pivotal role in the cellular metabolic response to fasting. Short-term starvation caused hepatic steatosis, myocardial lipid accumulation, and hypoglycemia, with an ..
  57. pmc Prolonged fasting identifies skeletal muscle mitochondrial dysfunction as consequence rather than cause of human insulin resistance
    Joris Hoeks
    Department of Human Biology, School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    Diabetes 59:2117-25. 2010
    ..dysfunction is secondary to the development of insulin resistance, we employed the unique model of prolonged fasting in humans...
  58. doi The circulating metabolic regulator FGF21 is induced by prolonged fasting and PPARalpha activation in man
    Cecilia Gälman
    Department of Endocrinology, Metabolism and Diabetes, Molecular Nutrition Unit, Karolinska Institutet, Karolinska University Hospital Huddinge, S 141 86 Stockholm, Sweden
    Cell Metab 8:169-74. 2008
    FGF21 is a critical metabolic regulator, pivotal for fasting adaptation and directly regulated by PPARalpha in rodents. However, the physiological role of FGF21 in man is not yet defined and was investigated in our study...
  59. pmc Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis
    James Rhee
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:4012-7. 2003
    The liver plays several critical roles in the metabolic adaptation to fasting. We have shown previously that the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) is induced in ..
  60. ncbi The role of alpha-cell dysregulation in fasting and postprandial hyperglycemia in type 2 diabetes and therapeutic implications
    Beth Elaine Dunning
    PharmaWrite, Princeton, New Jersey 08540, USA
    Endocr Rev 28:253-83. 2007
    ..The evidence that glucagon excess contributes to the development and maintenance of fasting hyperglycemia and that failure to suppress glucagon secretion contributes to postprandial hyperglycemia is then ..
  61. ncbi Nontraumatic fracture risk with diabetes mellitus and impaired fasting glucose in older white and black adults: the health, aging, and body composition study
    Elsa S Strotmeyer
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Arch Intern Med 165:1612-7. 2005
    ..Diabetes mellitus (DM) and related complications may increase clinical fracture risk in older adults...
  62. pmc Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1alpha in skeletal muscle
    Orsolya M Palacios
    USDA ARS Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Aging (Albany NY) 1:771-83. 2009
    ..we find that SIRT3 protein levels in skeletal muscle are sensitive to diet, for SIRT3 expression increases by fasting and caloric restriction, yet it is decreased by high-fat diet...
  63. pmc Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake
    R Michael Anson
    Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 100:6216-20. 2003
    ..We report that when C57BL6 mice are maintained on an intermittent fasting (alternate-day fasting) dietary-restriction regimen their overall food intake is not decreased and their body ..
  64. pmc Calcium signaling through CaMKII regulates hepatic glucose production in fasting and obesity
    Lale Ozcan
    Department of Medicine, Columbia University, New York, NY 10032, USA
    Cell Metab 15:739-51. 2012
    ..activated in a calcium- and IP3R-dependent manner by cAMP and glucagon in primary hepatocytes and by glucagon and fasting in vivo...
  65. doi Green tea intake lowers fasting serum total and LDL cholesterol in adults: a meta-analysis of 14 randomized controlled trials
    Xin Xin Zheng
    Key Laboratory for Clinical Cardiovascular Genetics and Sino German Laboratory for Molecular Medicine, Cardiovascular Institute, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing, China
    Am J Clin Nutr 94:601-10. 2011
    ..The effect of green tea beverage and green tea extract on lipid changes is controversial...
  66. pmc Free fatty acids link metabolism and regulation of the insulin-sensitizing fibroblast growth factor-21
    Knut Mai
    Department of Endocrinology, Diabetes and Nutrition, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Diabetes 58:1532-8. 2009
    ..FGF-21 has been suggested to be a peroxisome proliferator-activator receptor (PPAR) alpha-dependent regulator of fasting metabolism, we hypothesized that free fatty acids (FFAs), natural agonists of PPARalpha, might modify FGF-21 ..
  67. pmc Post-fasting olfactory, transcriptional, and feeding responses in Drosophila
    Shelli F Farhadian
    Laboratory of Neurogenetics and Behavior, The Rockefeller University, 1230 York Avenue, Box 63, New York, NY 10065, USA
    Physiol Behav 105:544-53. 2012
    The sensation of hunger after a period of fasting and of satiety after eating is crucial to behavioral regulation of food intake, but the biological mechanisms regulating these sensations are incompletely understood...
  68. pmc Gene expression profile change and associated physiological and pathological effects in mouse liver induced by fasting and refeeding
    Fang Zhang
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    PLoS ONE 6:e27553. 2011
    ..Biological process and pathway analysis showed that fasting mainly affected lipid and carboxylic acid metabolic processes in liver...
  69. doi Refeeding after fasting elicits insulin-dependent regulation of Per2 and Rev-erbα with shifts in the liver clock
    Yu Tahara
    Department of Physiology and Pharmacology, School of Advanced Science and Engineering, Waseda University, Tokyo, Japan
    J Biol Rhythms 26:230-40. 2011
    ..Our results indicate that an acute change of Per2 and Rev-erbα gene expression mediated by refeeding-induced insulin secretion is a critical step mediating the early phase of feeding-induced entrainment of the liver clock...
  70. doi Rapid development of fasting-induced hepatic lipidosis in the American mink (Neovison vison): effects of food deprivation and re-alimentation on body fat depots, tissue fatty acid profiles, hematology and endocrinology
    Kirsti Rouvinen-Watt
    Department of Plant and Animal Sciences, Nova Scotia Agricultural College, Truro, NS, Canada
    Lipids 45:111-28. 2010
    ..This could be a key contributor to the pathophysiology of fatty liver disease in mink influencing disease progression...
  71. doi Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes
    Ting Lu
    Department of Endocrinology, Xuhui District Central Hospital, Shanghai, China
    Nutr Res 32:408-12. 2012
    ..double-blinded clinical study to analyze the effect of cinnamon extract on glycosylated hemoglobin A(1c) and fasting blood glucose levels in Chinese patients with type 2 diabetes...
  72. doi α-lipoic acid can improve endothelial dysfunction in subjects with impaired fasting glucose
    Guangda Xiang
    Department of Endocrinology, Wuhan General Hospital of Guangzhou Command, Wuhan 430070, Hubei Province, PR China
    Metabolism 60:480-5. 2011
    ..studies showed that impairment of endothelium-dependent arterial dilation (EDAD) exists in subjects with impaired fasting glucose (IFG). The crucial mechanism of this endothelial dysfunction remains unclear...
  73. pmc Impaired fasting glucose is associated with renal hyperfiltration in the general population
    Toralf Melsom
    Department of Medical Biochemistry, University Hospital of North Norway, and the Department of Clinical Medicine, University of Tromsø, Tromsø, Norway
    Diabetes Care 34:1546-51. 2011
    ..We assessed whether impaired fasting glucose (IFG; 5.6-6...
  74. pmc Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies
    Jennifer A Nettleton
    Division of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas Health Sciences Center, Houston, Houston, Texas, USA
    Diabetes Care 33:2684-91. 2010
    ..association studies (GWAS) have identified several single nucleotide polymorphisms (SNPs) associated with fasting glucose and insulin concentrations in individuals free of diabetes...
  75. pmc Elevated fasting insulin predicts the future incidence of metabolic syndrome: a 5-year follow-up study
    Ki Chul C Sung
    Division of Cardiology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea
    Cardiovasc Diabetol 10:108. 2011
    ..We aimed to assess whether the baseline insulin levels could predict the development of MS in a well characterised cohort of otherwise healthy adults who were followed over a five year period...
  76. pmc Effects of 16 genetic variants on fasting glucose and type 2 diabetes in South Asians: ADCY5 and GLIS3 variants may predispose to type 2 diabetes
    Simon D Rees
    College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom
    PLoS ONE 6:e24710. 2011
    ..of Glucose and Insulin related traits Consortium (MAGIC) recently identified 16 loci robustly associated with fasting glucose, some of which were also associated with type 2 diabetes...
  77. pmc Impact of A1C screening criterion on the diagnosis of pre-diabetes among U.S. adults
    Devin M Mann
    Department of Medicine, Division of General Internal Medicine, Mount Sinai School of Medicine, New York, New York, USA
    Diabetes Care 33:2190-5. 2010
    New clinical practice recommendations include A1C as an alternative to fasting glucose as a diagnostic test for identifying pre-diabetes. The impact of these new recommendations on the diagnosis of pre-diabetes is unknown.
  78. ncbi Fasting increases and satiation decreases olfactory detection for a neutral odor in rats
    P Aimé
    Laboratoire de Neurosciences Sensorielles, Comportement, Cognition, CNRS, UMR 5020, Universite Claude Bernard Lyon 1, 50 avenue Tony Garnier, 69366 Lyon Cedex 07, France
    Behav Brain Res 179:258-64. 2007
    ..Since these results were obtained using a neutral odor, we suggest that olfactory acuity increases during fasting, enabling animals to more easily detect both food and environmental odors such as those of predators...
  79. doi Fasting plasma glucose and HbA1c as risk factors for Type 2 diabetes
    Kazuo Inoue
    Department of Public Health, Graduate School Medicine, University of Tokyo, Tokyo, Japan
    Diabet Med 25:1157-63. 2008
    We examined the value of combining fasting plasma glucose (FPG) and glycated haemoglobin (HbA(1c)) as a predictor of diabetes, using the new American Diabetes Association (ADA) criteria of FPG and lower cut-off point of HbA(1c).
  80. ncbi Upregulation of Ghrelin expression in the stomach upon fasting, insulin-induced hypoglycemia, and leptin administration
    K Toshinai
    Third Department of Internal Medicine, Miyazaki Medical College, Miyazaki, 889 1692, Japan
    Biochem Biophys Res Commun 281:1220-5. 2001
    ..in rat stomach, with the ratio of des-octanoylated ghrelin to n-octanoylated ghrelin markedly increased after fasting. The ghrelin mRNA level in the stomach also increased after administration of insulin and leptin...
  81. doi Perioperative fasting in adults and children: guidelines from the European Society of Anaesthesiology
    Ian Smith
    Directorate of Anaesthesia, University Hospital of North Staffordshire, Stoke on Trent, UK
    Eur J Anaesthesiol 28:556-69. 2011
    This guideline aims to provide an overview of the present knowledge on aspects of perioperative fasting with assessment of the quality of the evidence...
  82. pmc Increased arterial stiffness in healthy subjects with high-normal glucose levels and in subjects with pre-diabetes
    Jin Young Shin
    Department of Family Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
    Cardiovasc Diabetol 10:30. 2011
    Increased fasting plasma glucose (FPG), which includes impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and diabetes, is a risk factor for arterial stiffness...
  83. pmc Fasting C-peptide levels and death resulting from all causes and breast cancer: the health, eating, activity, and lifestyle study
    Melinda L Irwin
    Yale School of Public Health, P O Box 208034, New Haven, CT 06520 8034, USA
    J Clin Oncol 29:47-53. 2011
    ..To examine the association between serum C-peptide, a marker of insulin secretion, measured 3 years after a breast cancer diagnosis, and death resulting from all causes and breast cancer...
  84. ncbi Desnutrin, an adipocyte gene encoding a novel patatin domain-containing protein, is induced by fasting and glucocorticoids: ectopic expression of desnutrin increases triglyceride hydrolysis
    Josep A Villena
    Department of Nutritional Sciences and Toxicology, University of California, Berkeley, California 94720, USA
    J Biol Chem 279:47066-75. 2004
    ..Desnutrin mRNA levels were regulated by the nutritional status of animals, being transiently induced during fasting. In vitro desnutrin gene expression was up-regulated by dexamethasone in a dose-dependent manner but not by cAMP, ..
  85. ncbi Assessment of dietary consumption and time-course of changes in serum lipids and lipoproteins before, during and after Ramadan in young Algerian adults
    M Y Lamri-Senhadji
    Laboratoire de Nutrition Clinique et Métabolique, Faculte des Sciences, Department de Biologie, Université d Oran, 31100 Es Sénia, Algeria
    Singapore Med J 50:288-94. 2009
    During the month of Ramadan, fasting is obligatory for all healthy adult Muslims, with the only exempted adults being those who have to travel or are sick...
  86. pmc Pioglitazone decreases fasting and postprandial endogenous glucose production in proportion to decrease in hepatic triglyceride content
    Balasubramanian Ravikumar
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, U K
    Diabetes 57:2288-95. 2008
    ..We studied the effect of pioglitazone on hepatic triglyceride content and the consequent effect on postprandial endogenous glucose production (EGP) in type 2 diabetes...
  87. ncbi Beneficial effects of intermittent fasting and caloric restriction on the cardiovascular and cerebrovascular systems
    Mark P Mattson
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
    J Nutr Biochem 16:129-37. 2005
    Intermittent fasting (IF; reduced meal frequency) and caloric restriction (CR) extend lifespan and increase resistance to age-related diseases in rodents and monkeys and improve the health of overweight humans...
  88. ncbi Homeostasis model assessment is more reliable than the fasting glucose/insulin ratio and quantitative insulin sensitivity check index for assessing insulin resistance among obese children and adolescents
    Mehmet Keskin
    Department of Pediatrics, School of Medicine, Erciyes University, 38039, Kayseri, Turkey
    Pediatrics 115:e500-3. 2005
    Simple fasting methods to measure insulin resistance, such as the homeostasis model assessment (HOMA), fasting glucose/insulin ratio (FGIR), and quantitative insulin sensitivity check index (QUICKI) methods, have been widely promoted for ..
  89. ncbi Fasting blood glucose and cancer risk in a cohort of more than 140,000 adults in Austria
    K Rapp
    Department of Epidemiology, University of Ulm, Ulm, Germany
    Diabetologia 49:945-52. 2006
    We investigated relations between fasting blood glucose and the incidence of cancer.
  90. ncbi An investigation into the acute and long-term effects of selected yogic postures on fasting and postprandial glycemia and insulinemia in healthy young subjects
    S Manjunatha
    Department of Physiology, All India Institute of Medical Sciences, New Delhi
    Indian J Physiol Pharmacol 49:319-24. 2005
    ..The study is significant in that it has for the first time attempted to probe the mechanism by which yogasanas help diabetes mellitus...
  91. ncbi Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene
    S Kersten
    Institut de Biologie Animale, Universite de Lausanne, CH 1015, Switzerland
    J Biol Chem 275:28488-93. 2000
    b>Fasting is associated with significant changes in nutrient metabolism, many of which are governed by transcription factors that regulate the expression of rate-limiting enzymes...
  92. ncbi Concurrent alterations of O-GlcNAcylation and phosphorylation of tau in mouse brains during fasting
    Xu Li
    Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, P R China
    Eur J Neurosci 23:2078-86. 2006
    ..regulates protein O-GlcNAcylation, and the latter modulates phosphorylation of tau inversely, we investigated, in fasting Kunming mice, whether impaired brain glucose uptake/metabolism causes abnormal hyperphosphorylation of tau and, ..
  93. ncbi Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women
    Sandeep Bansal
    Donald W Reynolds Center for Cardiovascular Research, Brigham and Women s Hospital, Boston, MA 02215, USA
    JAMA 298:309-16. 2007
    ..Although triglyceride levels are typically obtained in the fasting state, postprandial hypertriglyceridemia may play an important role in atherosclerosis.
  94. pmc Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy
    M D Gomes
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 98:14440-5. 2001
    Muscle wasting is a debilitating consequence of fasting, inactivity, cancer, and other systemic diseases that results primarily from accelerated protein degradation by the ubiquitin-proteasome pathway...
  95. pmc SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
    Matthew D Hirschey
    Gladstone Institute of Virology and Immunology, San Francisco, California 94158, USA
    Nature 464:121-5. 2010
    ..Here we report that SIRT3 expression is upregulated during fasting in liver and brown adipose tissues...
  96. ncbi Defect in peroxisome proliferator-activated receptor alpha-inducible fatty acid oxidation determines the severity of hepatic steatosis in response to fasting
    T Hashimoto
    Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611 3008, USA
    J Biol Chem 275:28918-28. 2000
    b>Fasting causes lipolysis in adipose tissue leading to the release of large quantities of free fatty acids into circulation that reach the liver where they are metabolized to generate ketone bodies to serve as fuels for other tissues...
  97. ncbi CREB regulates hepatic gluconeogenesis through the coactivator PGC-1
    S Herzig
    Peptide Biology Laboratories, Salk Institute for Biological Studies, 10010 N Torrey Pines Road, La Jolla, California 92037 1002, USA
    Nature 413:179-83. 2001
    ..response element binding (CREB) protein gene, or overexpressing a dominant-negative CREB inhibitor, exhibit fasting hypoglycaemia [corrected] and reduced expression of gluconeogenic enzymes...
  98. pmc The transcriptomic signature of fasting murine liver
    Milka Sokolovic
    AMC Liver Center, Academic Medical Center, University of Amsterdam, The Netherlands
    BMC Genomics 9:528. 2008
    The contribution of individual organs to the whole-body adaptive response to fasting has not been established...
  99. doi Patient-directed titration for achieving glycaemic goals using a once-daily basal insulin analogue: an assessment of two different fasting plasma glucose targets - the TITRATE study
    L Blonde
    Ochsner Diabetes Clinical Research Unit, Department of Endocrinology, Diabetes and Metabolic Diseases, Ochsner Medical Center, New Orleans, LA, USA
    Diabetes Obes Metab 11:623-31. 2009
    To compare efficacy and safety of two fasting plasma glucose (FPG) titration targets [4.4-6.1 mmol/l (80-110 mg/dl) and 3.9-5...
  100. ncbi Type 2 diabetes and impaired fasting blood glucose in rural Bangladesh: a population-based study
    Akhtar Hussain
    Institute of General Practice and Community Medicine, Department of International Health, University of Oslo, Norway
    Eur J Public Health 17:291-6. 2007
    ..Therefore, it is of particular interest to study the epidemiological transition of the state and to identify the risk factors in order to recognize the extent of the problem...
  101. doi Long-chain omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid dose-dependently reduce fasting serum triglycerides
    Kathy Musa-Veloso
    Cantox Health Sciences International, Mississauga, Ontario, Canada
    Nutr Rev 68:155-67. 2010
    ..the long-chain omega-3 fatty acids eicosapentaenoic acid and/or docosahexaenoic acid dose-dependently reduce fasting serum triglycerides (TG) and, if so, to create a mathematical model that may be used to predict potential percent ..

Research Grants74

  1. Pyruvate Dehydrogenase kinase as Therapeutic Target for Hepatic Steatosis, Obesit
    Robert A Harris; Fiscal Year: 2012
    ..of the proposal are: (a) determine the effects that knocking out both PDK2 and PDK4 in the same mouse has upon fasting blood glucose levels, glucose tolerance, insulin sensitivity, hepatic steatosis, adiposity, branched chain amino ..
  2. Brain Activation responses in adolescents with genetic predisposition to obesity
    Susan Carnell; Fiscal Year: 2011
    ..b>Fasting levels of gut hormones will be assessed during the physical...
  3. Pharmacogenetics of obesity and endocannabinergic modulation (POEM)
    Russell A Wilke; Fiscal Year: 2012
    ..12 quantitative traits: body mass index (BMI), waist circumference, hip circumference, waist/hip ratio (WHR), fasting glucose, insulin, insulin/glucose ratio, homeostasis model assessment of insulin resistance (HOMA-IR), fasting ..
  4. The gastric X/A-like (ghrelin) cell: A peripheral regulator of food intake
    NILS WG LAMBRECHT; Fiscal Year: 2012
    ..2) Effect of fasting (24 hr food restriction) and re-feeding on (a) nesfatin-1/NUCB2 concentration and ghrelin/desacyl ghrelin (DAG) ..
  5. Autonomic, Endothelial, and Inflammatory Correlates of Sleep Duration
    MERCEDES RENEE CARNETHON; Fiscal Year: 2012
    ..tumor necrosis factor-1, plasminogen activator inhibitor-1) and inflammation (C-reactive protein) measured in fasting blood...
  6. Regulation of thyroid hormone levels by central and peripheral pathways
    KRISTEN RACHEL VELLA; Fiscal Year: 2013
    ..As I transition from postdoctoral fellow to Instructor, I look to target the specific neurons responsible for fasting-induced suppression of TH levels and use the results of this research to apply for extramural funding, such as an ..
  7. Role of Txnip in adapting fuel metabolism to nutritional state
    SIMON HUI; Fiscal Year: 2013
    ..TKO) mice become hypoglycemia, hypertriglycerdemia and hyperketonemia when fasted and cannot survive long-term fasting. Using tissue-specific Txnip knockout mice, we have identified that impaired mitochondrial oxidation in the ..
  8. Impact of the P479L Variant in CPT1A on Infant Mortality in Alaska
    David M Koeller; Fiscal Year: 2011
    ..CPT1A is the liver isoform of CPT1 and is required for ketogenesis during periods of fasting. Patients with severe forms of CPT1A deficiency can present with a wide variety of symptoms, including ..
  9. Response to and signals of caloric restriction and intermittent feeding regimens
    MARC KOPEL HELLERSTEIN; Fiscal Year: 2010
    ..Our studies have shown that intermittent feeding (IF) regimens such as modifed alternate-day fasting (mADF) reproduce many of the benefits of true CR in mice, without weight loss or change in body composition...
  10. Neurobehavioral Correlates of Familial/genetic obesity risk in adolescents
    Susan Carnell; Fiscal Year: 2013
    ..b>Fasting levels of gut hormones will be assessed during the physical...
  11. METABOLIC SYNDROME AND PERIODONTITIS IN POSTMENOPAUSAL WOMEN
    Michael J LaMonte; Fiscal Year: 2013
    ..composition;questionnaires on lifestyle habits, oral hygiene and medical history;resting blood pressure;and a fasting blood sample meticulously collected, processed and frozen, that have had relevant biomarkers measured...
  12. Retinoid Metabolism and Alcohol Induced Disease
    William S Blaner; Fiscal Year: 2010
    ..the sole transport protein for retinol in the circulation, accounting for >95% of the retinoid present in the fasting circulation...
  13. VitC to Decrease Effects of Smoking in Pregnancy on Infant Lung Function-CCC-Lead
    CYNTHIA T MCEVOY; Fiscal Year: 2013
    ..smoking and medication compliance, including urine cotinines levels, smoking questionnaires, pill counts and fasting plasma ascorbic acid levels...
  14. Osteocalcin and Metabolic Risk Factors. The Framingham Study
    Yi Hsiang Hsu; Fiscal Year: 2011
    ..effects on both serum OC and metabolic risk factors (including waist circumference, systolic blood pressure, fasting triglycerides, fasting HDL cholesterol, fasting plasma glucose, fasting plasma insulin, adiponectin ..
  15. The Relationship Between STK39, Salt Sensitivity, and HCTZ-induced BP Response
    YEN PEI CHRISTY CHANG; Fiscal Year: 2010
    ..Interestingly, the STK39 genotypes associated with higher BP are also associated with lower fasting glucose, raising the possibility that STK39 genotypes might predict a subgroup of salt-sensitive hypertensives ..
  16. JNK exacerbates ischemia/reperfusion injury in hyperglycemic subjects.
    Keith A Webster; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Fasting hyperglycemia is associated with increased myocardial infarction in both animal models and patients...
  17. Sex Hormones in Postmenopausal Women in the Diabetes Prevention Program
    Catherine Kim; Fiscal Year: 2012
    ..The DPP enrolled participants with either impaired fasting glucose or impaired glucose tolerance, 45% of whom were non-white, and the DPP also obtained multiple measures of ..
  18. Early Life Conditions, Survival, and Health: A Pedigree-Based Population Study
    Ken R Smith; Fiscal Year: 2013
    ..acid, creatinine, serum cholesterol, glycosylated hemoglobin, dehydroepiandrosterone sulfate (DHEAS &DHEA), fasting glucose and insulin resistance, telomere length, blood pressure, heart rate, grip strength, forced expiratory ..
  19. Role of leptin-mediated PI3 Kinase signaling on reproductive control
    Carol Fuzeti Elias; Fiscal Year: 2013
    ..Leptin also blunts the fasting-induced suppression of LH secretion and fertility...
  20. Atypical PKC Knockout Models: Effect on Glucose and Lipid Homeostasis
    Robert V Farese; Fiscal Year: 2013
    ..protects lipid and glucose homeostasis by diminishing activation of hepatic SREBP-1c and NF B, and by diminishing fasting-dependent expression of PEPCK and glucose-6-phosphatase (G6Pase)...
  21. Undercarboxylated osteocalcin, body fat, and diabetes in older adults
    Ann V Schwartz; Fiscal Year: 2010
    ..those with and without diabetes, the study will also determine whether ucOC levels at baseline predict changes in fasting glucose, A1C and insulin resistance, in lipids (serum triglycerides, total cholesterol, LDLc, HDLc, nonHDLc, and ..
  22. Arsenic Exposure, Genetic Determinants and Diabetes Risk in a Family Study
    Ana Navas-Acien; Fiscal Year: 2013
    ..Demographic, lifestyle and medical information and measures of fasting glucose and insulin, lipid profile, hypertension endpoints, body mass index, and waist and hip circumferences are ..
  23. A Culturally Tailored LIfestyle Intervention to Prevent Diabetes in South Asians:
    KABAYAM M VENKAT NARAYAN; Fiscal Year: 2010
    ..Secondary outcomes are changes in percent body fat, body mass index, waist-to-hip ratio, fasting glucose, blood pressure, plasma lipids, activity, and diet...
  24. Hypothalamic SIRT1 and Energy Balance
    Eduardo A Nillni; Fiscal Year: 2013
    ..availability to energy homeostasis at the hypothalamic level, and this effect depends -at least in part- on the fasting induced and Sirt1 mediated regulation of FoxO1 deacetylation and mTOR signaling...
  25. Effects of GSH +/- Arginine on Markers of Inflammation Among Adults with CVD Risk
    Christopher D Gardner; Fiscal Year: 2010
    ..Secondary outcomes include blood pressure, blood cholesterol, fasting insulin, serum isoprostanes (a measure of oxidative stress) and s-nitrosyl glutathione (a stable, nitric oxide ..
  26. Exploring persistent epigenetic changes after prenatal famine exposure in humans
    L H Lumey; Fiscal Year: 2010
    ..to disease risk factors for cardio-vascular disease and diabetes such as obesity, elevated blood cholesterol or fasting glucose values...
  27. VitC to Decrease Effects of Smoking in Pregnancy on Infant Lung Function-DCC
    Cynthia D Morris; Fiscal Year: 2013
    ..smoking and medication compliance, including urine cotinines levels, smoking questionnaires, pill counts and fasting plasma ascorbic acid levels...
  28. Regulation of Triglyceride Metabolism by the transcription factor CREB-H
    Ann Hwee Lee; Fiscal Year: 2013
    ..CREB-H is induced by fatty acids, the fatty acid oxidation regulator PPAR1, and fasting in the liver, suggesting that it might participate in nutrient and energy metabolism...
  29. Comparative Effectiveness of Medical Therapy vs. Bariatric Surgery for Obese T2DM
    DAVID BRADLEY contact LAUTZ; Fiscal Year: 2010
    ..endpoint of this 2-year feasibility study will be glycemic control 12 months after randomization, assessed as fasting plasma glucose levels <126 mg/dL and HbA1c <6.5%...
  30. Lifespan Extension Despite Greatly Elevated Insulin and Body Fat
    David E Harrison; Fiscal Year: 2013
    ..In vivo tests to identify this point will include short-term fasting glucose and insulin levels, glucose tolerance, insulin sensitivity, gluconeogenesis, glycogenolysis, beta-..
  31. NPC1L1 and Metabolic Diseases
    Liqing Yu; Fiscal Year: 2013
    ..at biochemical and gene expression levels in WT and L1KO mice under dietary excess, ezetimibe treatment or fasting conditions...
  32. Regulation of Hepatic Lipid and Glucose Metabolism by PC-TP/StarD2
    David E Cohen; Fiscal Year: 2013
    ..Them2 limits insulin signaling and thereby promotes hepatic glucose production and triglyceride synthesis under fasting conditions...
  33. Hyperglycemia and Pregnancy Outcome(HAPO)Follow Up Study
    Boyd E Metzger; Fiscal Year: 2013
    ..and independently associated with later maternal risk of disorders of glucose metabolism (diabetes, impaired fasting glucose, impaired glucose tolerance)...
  34. Metabolic Actions of Omega-3 Fatty Acids on Inflammation
    Michael Miller; Fiscal Year: 2013
    ..3 of the following components: central obesity, high triglycerides, low HDL, abnormal blood pressure and impaired fasting glucose levels...
  35. Insulin Signaling and Metabolic Effects through CLK2 Kinase
    Pere Puigserver; Fiscal Year: 2013
    ..the effects of Clk2 on hepatic glucose and lipid metabolism in mice through loss-of-function of hepatic Clk2 in fasting/feeding cycles and genetic and diet-induced obesity...
  36. Growth hormone and adult physiology
    Rhonda D Kineman; Fiscal Year: 2013
    ..muscle) 3) determine if AOiGHD will influence whole body metabolism and weight changes in response to acute fasting/refeeding or longterm diet-induced weight loss...
  37. Novel PPAR-Independent Peroxisome Proliferators for Type 2 Diabetes
    LIDIA NIEROBISZ; Fiscal Year: 2011
    ..The proof of principle compound reduces fasting blood glucose, decreases plasma free fatty acids and decreases lipid accumulation in the liver...
  38. Maternal Obesity and Gestational Diabetes: Impact on Metabolome
    William L Lowe; Fiscal Year: 2013
    ..the hypothesis that distinct metabolic signatures are independently associated with maternal metabolic traits (fasting, 1 hr., and 2 hr...
  39. Energy Balance During Ketosis in Rat Brain
    JOSEPH CHARLES LAMANNA; Fiscal Year: 2010
    ..fuel for brain, ketones supplement brain metabolism, especially under conditions of glucose sparing, such as fasting, starvation or high fat-low carbohydrate diet...
  40. The New England Family Study: Fifty Year Post-Perinatal Follow-Up for Life Course
    ERIC contact LOUCKS; Fiscal Year: 2010
    ..assessments include adiposity, atherosclerosis (coronary artery calcium CT scans), cognitive function, diabetes (fasting glucose), and cardiovascular risk factors (e.g. lipids)...
  41. Mediators of Atherosclerosis in South Asians Living in America
    Alka M Kanaya; Fiscal Year: 2013
    ..Pakistan, Nepal, Bangladesh, and Sri Lanka) represent a quarter of the world's population and are one of the fasting growing ethnic groups in the United States...
  42. Role of the insulin/IGF-axis in incident CIN-2+
    Howard D Strickler; Fiscal Year: 2010
    ..serum levels of IGF-I, IGF-II, IGFBP-3, and C-peptide (a surrogate marker of insulin that does not require fasting blood), in N=182 GP women with persistent oncogenic HPV, and N=142 with incident cervical pre-cancer (i.e...
  43. Melanin-Concentrating Hormone: Ancestral Role in Feeding &Sleep Regulation
    Philippe Mourrain; Fiscal Year: 2013
    ..MCH2, like mammalian hMCH, is expressed in a distinct population of hypothalamic neurons and is up-regulated upon fasting, suggesting a conservation of MCH2/hMCH regulation and function across vertebrates...
  44. Pulmonary Vascular-Right Ventricular Axis Research Program
    Wai Hong Wilson Tang; Fiscal Year: 2013
    ..expression and uptake of the glucose analogue [18F]2-fluoro-2-deoxy-D-glucose by positron emission tomography (fasting FDG-PET) in PAH patients...
  45. SIRT1 as a regulator of health and lifespan of mammals
    David A Sinclair; Fiscal Year: 2013
    ..reactive oxygen species (ROS) and lactate, and a failure of muscle mitochondria to adapt their metabolism to fasting. Strikingly, this same defect occurs in wild type mice as they age...
  46. Cellular Mechanisms for Increased Gluconeogenesis in Type 2 Diabetes
    Varman T Samuel; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): In patients with T2D, increased hepatic gluconeogenesis is the main cause of fasting hyperglycemia...
  47. Classical and non-classical responses to vitamin D in children: the role of DBP g
    Thomas O Carpenter; Fiscal Year: 2010
    ..changes in BMI, incidence of infection, blood pressure, insulin sensitivity (using measures derived from fasting insulin and cortisol levels) and circulating levels of aldosterone and renin...
  48. Vitamin D and Vascular Function in Obese Children
    Kumaravel Rajakumar; Fiscal Year: 2013
    ..pulse wave velocity as a measure of arterial stiffness;(3) surrogate estimates of insulin sensitivity (fasting glucose/fasting insulin ratio or Homeostasis Model of Assessment - Insulin Resistance [HOMA-IR]);(4) metabolic ..
  49. Establishing the Precursors of Osteoporosis in Children
    Xiping Xu; Fiscal Year: 2010
    ..the funded MS study, including steroid hormones: androgen, estrogen, testosterons, LH, and FSH;metabolic markers: fasting and 2-hr post OGTT insulin, glucose, HOMA-IR, fasting lipids;growth hormones: insulin-like growth factor (IGF-I);..
  50. Appetite-regulating Hormones and Neurocircuitry in Anorexia Nervosa
    ELIZABETH AUSTEN LAWSON; Fiscal Year: 2013
    ..During a single visit, subjects will undergo measurement of BMI;a fasting blood draw for hormone levels (eg, ghrelin, PYY);assessment of appetite, mood and disordered eating ..
  51. RISK FACTORS FOR CVD IN WOMEN
    JOANN ELISABETH MANSON; Fiscal Year: 2012
    ..Blood samples were collected from 32,826 participants in 1989-1990 (with 18,664 fasting), and detailed nutritional, behavioral, and lifestyle variables have been collected biennially...
  52. Biopsychosocial Determinants of Adolescent Obesity/Cardiovascular Risk
    Sheila Gahagan; Fiscal Year: 2012
    ..In addition, we will measure anthropometry, fat and muscle mass (DXA), fasting glucose, insulin (HOMA IR), lipids, leptin, ghrelin, adiponectin, orexin, CRP, and TNF alpha...
  53. Systemic Factors that Maintain a Young Liver Phenotype
    Roy G Smith; Fiscal Year: 2012
    ..During CR and fasting, production of the hormone ghrelin increases and the ghrelin receptor (GHS-R1a) expressed in the hypothalamus is ..
  54. Renin-angiotensin and fibrinolysis interaction in humans
    NANCY JOAN BROWN; Fiscal Year: 2013
    ..An effect of ACE inhibition on incident diabetes was not replicated in patients with impaired fasting glucose in the Diabetes Reduction Assessment with Ramipril and Rosiglitazone Medication trial...
  55. Metabolic Syndrome and Periodontitis
    ELIZABETH A KAYE; Fiscal Year: 2013
    ..Serum lipids, fasting serum glucose, body mass index and waist circumference were also measured every 3 years over the same time period...
  56. CONTROL OF GONADOTROPIN SECRETION DURING LACTATION
    Kevin L Grove; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): It is firmly established that states of energy deficiency, such as fasting, anorexia nervosa, cachexia, bulimia, lactation and exercise-induced amenorrhea, as well as states of energy overabundance, ..
  57. Structure and Function of Enzymes in Fatty Acid Oxidation
    JUNG JA P KIM; Fiscal Year: 2013
    ..The rate of this process can be altered by diet (fed/fasting), physiological status (pregnancy), or diseases (diabetes)...
  58. Regulation of Hepatic Gluconeogenesis by the CREB:TORC2 Pathway
    Marc R Montminy; Fiscal Year: 2010
    During fasting, elevations in circulating pancreatic glucagon promote hepatic glucose output through induction of the gluconeogenic program by the CREB coactivator TORC2...
  59. Lactation and Incidence of Diabetes Mellitus in CARDIA Women
    ERICA PAULINE GUNDERSON; Fiscal Year: 2013
    ..Entering its 25th year, CARDIA will have measured cardiometabolic risk factors (fasting glucose, insulin, lipids, BMI, waist girth, blood pressure) up to 8 times since baseline (1986-2011), and ..
  60. Regulation of Hepatic Gluconeogenesis by the CREB:TORC2 Pathway
    Marc R Montminy; Fiscal Year: 2013
    During fasting, elevations in circulating pancreatic glucagon promote hepatic glucose output through induction of the gluconeogenic program by the CREB coactivator TORC2...
  61. A simple dietary message to improve dietary quality for metabolic syndrome
    Yunsheng Ma; Fiscal Year: 2012
    ..Assessments, including diet, anthropometrics, blood pressure, fasting blood glucose, glycosylated hemoglobin (HbA1c), blood lipids, insulin, inflammatory markers, medication use, ..
  62. A Mindfulness-Based Approach to the Treatment of Obesity and Diabetes
    Carla K Miller; Fiscal Year: 2010
    ..The impact of the interventions on weight, glycemic control (HbA1c and fasting plasma glucose), insulin sensitivity, dietary intake, physical activity, depression, anxiety and self-efficacy ..
  63. Regulation of Carbohydrate Metabolism and Lipogenesis
    Kosaku Uyeda; Fiscal Year: 2013
    ..of ChREBP enhances the binding to 14-3-3 and is essential for export of ChREBP out of the nucleus under fasting conditions...
  64. GASTROINTESTINAL & CARDIAC RESPONSE TO SEMI-STARVATION
    Eleanor Young; Fiscal Year: 1991
    ..overcome the adverse effects of negative N balance and subsequent loss of lean muscle mass that occurs with total fasting. The safety and efficacy of these diets were strongly challenged following reports of adverse effects and of ..
  65. NEUROENDOCRINE CONTROL OF ANTERIOR PITUITARY HORMONES
    RHONDA KINEMAN; Fiscal Year: 2006
    ..To test this hypothesis, the effects of fasting on neuropeptide mRNA levels, in mice harboring defects in leptin synthesis (ob/ob), tissue source of leptin (AZIP-..
  66. DIETARY COMPOSITION, OBESITY, AND CARDIOVASCULAR RISK
    ERNST SCHAEFER; Fiscal Year: 2003
    ..C, HDL C, remnant lipoprotein C, Lp(a) C, insulin, glycosylated hemoglobin, glucose, and blood pressure) in the fasting and nonfasting state (4 hours after a meal) in 80 men and women (men greater than or equal to 50 and less than 65 ..
  67. CORONARY ARTERY DISEASE AND POSTPRANDIAL LIPOPROTEINS
    Henry Ginsberg; Fiscal Year: 1992
    Epidemiologic evidence for an association between risk for developing CAD and fasting levels of plasma lipids, lipoproteins and apolipoproteins is derived from international cross-sectional data, prospective within-country population ..
  68. Role of GLP-1 in Congenital Hyperinsulinism
    DIVA DEL CARMEN DE LEON; Fiscal Year: 2010
    ..mice) and that antagonism of the GLP-1 receptor by exendin-(9-39) suppresses insulin secretion and corrects fasting hypoglycemia in these mice...
  69. Endothelial Function Predictors in Adolescent Diabetes
    ROBERT PAUL HOFFMAN; Fiscal Year: 2010
    ..Unfortunately, most studies that have examined endothelial function in type 1 diabetes have done so in the usual fasting state. It is unknown what effect short-term glucose control and acute glucose level have on these measurements...
  70. TRH REGULATION/BIOSYNTHESIS AND PARAVENTRICULAR NUCLEUS
    RONALD MICHAEL LECHAN; Fiscal Year: 2010
    ..hormone under normal conditions and during special circumstances when metabolic adaptation is necessary such as fasting, infection and chronic illnesses...
  71. A Pilot of Customized Continuous Care Management of Obesity in Pre-Diabetics
    Jun Ma; Fiscal Year: 2010
    ..a Customized Continuous Care Management (CCCM) model with patients who are obese or overweight and have impaired fasting glucose in a primary care setting...
  72. Hyperhomocysteinemia in Alzheimer's Disease
    Ramon Diaz Arrastia; Fiscal Year: 2003
    ..We plan to do this through the following specific aims: (a) Determine whether fasting or post-methionine load (PML) are best associated with AD...
  73. Molecular Epidemiology of Recurrent Aphthous Stomatitis: Role of Ghrelin
    Lorena Baccaglini; Fiscal Year: 2009
    ..Specific Aim 1 (Circulating ghrelin): We will compare fasting total plasma ghrelin levels (1) in 60 cases (30 with and 30 without active ulcers) vs...
  74. Role of Oleylethanolamine in the Regulation of the HPT Axis
    Csaba Fekete; Fiscal Year: 2010
    ..anorexic actions, oleylethanolamine (OEA), in the regulation of the hypothalamic-pituitary-thyroid axis during fasting. Since we observed in our preliminary studies that OEA inhibits the fasting-induced activation of cfos in NPY ..