atherogenic diet

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Top Publications

  1. pmc Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1
    M Accad
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94141, USA
    J Clin Invest 105:711-9. 2000
  2. ncbi Lipid-induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet
    Naoto Matsuzawa
    Department of Disease Control and Homeostasis, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Hepatology 46:1392-403. 2007
  3. ncbi Components of metabolic syndrome and coronary artery disease in female Ossabaw swine fed excess atherogenic diet
    Melissa C Dyson
    Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri, USA
    Comp Med 56:35-45. 2006
  4. ncbi Guar gum consumption increases hepatic nuclear SREBP2 and LDL receptor expression in pigs fed an atherogenic diet
    Todd C Rideout
    Centre for Nutrition Modelling, Department of Animal and Poultry Science, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    J Nutr 137:568-72. 2007
  5. pmc Effects of atherogenic diet on hepatic gene expression across mouse strains
    Keith R Shockley
    The Jackson Laboratory, Bar Harbor, Maine 04605, USA
    Physiol Genomics 39:172-82. 2009
  6. ncbi Reduction of serum cholesterol and hypercholesterolemic atherosclerosis in rabbits by secoisolariciresinol diglucoside isolated from flaxseed
    K Prasad
    Department of Physiology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Circulation 99:1355-62. 1999
  7. pmc Loss of receptor-mediated lipid uptake via scavenger receptor A or CD36 pathways does not ameliorate atherosclerosis in hyperlipidemic mice
    Kathryn J Moore
    Lipid Metabolism Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Invest 115:2192-201. 2005
  8. ncbi Dyslipidemia and vascular dysfunction in diabetic pigs fed an atherogenic diet
    J L Dixon
    Department of Food Science and Human Nutrition, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia 65211, USA
    Arterioscler Thromb Vasc Biol 19:2981-92. 1999
  9. ncbi Antithrombotic potential of olive oil administration in rabbits with elevated cholesterol
    J P De La Cruz
    Department of Pharmacology and Therapeutics, School of Medicine, University of Malaga, Spain
    Thromb Res 100:305-15. 2000
  10. ncbi Attenuating effect of chlorella supplementation on oxidative stress and NFkappaB activation in peritoneal macrophages and liver of C57BL/6 mice fed on an atherogenic diet
    Hyo Seon Lee
    School of Food and Life Science and Biohealth Product Research Center, Inje University, Obang dong, Kimhae, Korea
    Biosci Biotechnol Biochem 67:2083-90. 2003

Detail Information

Publications205 found, 100 shown here

  1. pmc Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1
    M Accad
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94141, USA
    J Clin Invest 105:711-9. 2000
    ....
  2. ncbi Lipid-induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet
    Naoto Matsuzawa
    Department of Disease Control and Homeostasis, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Hepatology 46:1392-403. 2007
    ..Conversely, the high-fat component down-regulated the hepatic gene expression of antioxidant enzymes and might have increased oxidative stress...
  3. ncbi Components of metabolic syndrome and coronary artery disease in female Ossabaw swine fed excess atherogenic diet
    Melissa C Dyson
    Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri, USA
    Comp Med 56:35-45. 2006
    ..We conclude that relatively brief feeding of excess atherogenic diet produces striking features of metabolic syndrome and coronary artery disease in female Ossabaw swine.
  4. ncbi Guar gum consumption increases hepatic nuclear SREBP2 and LDL receptor expression in pigs fed an atherogenic diet
    Todd C Rideout
    Centre for Nutrition Modelling, Department of Animal and Poultry Science, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    J Nutr 137:568-72. 2007
    ..We conclude that the hypocholesterolemic effects of GG consumption are related to a reduction in hepatic free cholesterol concentration and associated increases in nuclear active SREBP2 expression and hepatic LDLr abundance...
  5. pmc Effects of atherogenic diet on hepatic gene expression across mouse strains
    Keith R Shockley
    The Jackson Laboratory, Bar Harbor, Maine 04605, USA
    Physiol Genomics 39:172-82. 2009
    ..The gene expression data and phenotype data have been made publicly available as an online tool for exploring the effects of atherogenic diet in inbred mouse strains (http://cgd-array.jax.org/DietStrainSurvey).
  6. ncbi Reduction of serum cholesterol and hypercholesterolemic atherosclerosis in rabbits by secoisolariciresinol diglucoside isolated from flaxseed
    K Prasad
    Department of Physiology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Circulation 99:1355-62. 1999
    ..The objective of this study was to determine the effect of SDG on various blood lipid and aortic tissue oxidative stress parameters and on the development of atherosclerosis in rabbits fed a high-cholesterol diet...
  7. pmc Loss of receptor-mediated lipid uptake via scavenger receptor A or CD36 pathways does not ameliorate atherosclerosis in hyperlipidemic mice
    Kathryn J Moore
    Lipid Metabolism Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Invest 115:2192-201. 2005
    ..study, Apoe-/- mice lacking SR-A or CD36, backcrossed into the C57BL/6 strain for 7 generations, were fed an atherogenic diet for 8 weeks...
  8. ncbi Dyslipidemia and vascular dysfunction in diabetic pigs fed an atherogenic diet
    J L Dixon
    Department of Food Science and Human Nutrition, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia 65211, USA
    Arterioscler Thromb Vasc Biol 19:2981-92. 1999
    ..This porcine model should provide insights into the etiology of human diabetic dyslipidemia and facilitate study of peripheral vascular and coronary artery disease in diabetic patients...
  9. ncbi Antithrombotic potential of olive oil administration in rabbits with elevated cholesterol
    J P De La Cruz
    Department of Pharmacology and Therapeutics, School of Medicine, University of Malaga, Spain
    Thromb Res 100:305-15. 2000
    ..the effect of dietary supplementation with virgin olive oil in an experimental model with rabbits fed an atherogenic diet (saturated fat 48% of total fat)...
  10. ncbi Attenuating effect of chlorella supplementation on oxidative stress and NFkappaB activation in peritoneal macrophages and liver of C57BL/6 mice fed on an atherogenic diet
    Hyo Seon Lee
    School of Food and Life Science and Biohealth Product Research Center, Inje University, Obang dong, Kimhae, Korea
    Biosci Biotechnol Biochem 67:2083-90. 2003
    ..nuclear factor kappa B (NFkappaB) activation in peritoneal macrophages and liver of C57BL/6 mice fed on an atherogenic diet. The animals were maintained on an atherogenic diet (control), or an atherogenic diet supplemented with 3% (w/..
  11. ncbi Effect of an indigenous herbal compound preparation 'Trikatu' on the lipid profiles of atherogenic diet and standard diet fed Rattus norvegicus
    Valsala Sivakumar
    Department of Zoology, Annamalai University, Annamalai Nagar, 608002 Tamil Nadu, India
    Phytother Res 18:976-81. 2004
    ..Hence 'Trikatu' can be used as a potent hypolipidaemic agent and it can reduce the atherosclerosis associated with a high fat diet...
  12. pmc A physiologically relevant atherogenic diet causes severe endothelial dysfunction within 4 weeks in rabbit
    Sudarshan Rai
    Departments of Cardiology and Medicine, University of Melbourne, Austin Health, Australia
    Int J Exp Pathol 90:598-604. 2009
    ..This model could be used to study the early onset of endothelial dysfunction prior to the initiation of atherosclerosis...
  13. ncbi Atherogenic diet leads to posttranslational down-regulation of murine hepatocyte SR-BI expression
    Andreas Niemeier
    Department of Biochemistry and Molecular Biology II, Molecular Cell Biology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20249 Hamburg, Germany
    Atherosclerosis 202:169-75. 2009
    ..In SREBP-1a and -1c transgenic mice on normal chow, SR-BI was transcriptionally down-regulated. When fed the atherogenic diet, the posttranslational SR-BI regulation was still functional on this background...
  14. ncbi Effects of atherogenic diet consumption on lipoproteins in mouse strains C57BL/6 and C3H
    B Y Ishida
    Children s Hospital Oakland Research Institute, CA 94609
    J Lipid Res 32:559-68. 1991
    ..Plasma lipoproteins from female mice fed chow or an atherogenic diet displayed strain differences in lipoprotein particle sizes and apolipoprotein (apo) composition...
  15. ncbi Maternal atherogenic diet in swine is protective against early atherosclerosis development in offspring consuming an atherogenic diet post-natally
    J F Norman
    Division of Physical Therapy Education and Department of Pediatrics, University of Nebraska Medical Center, Omaha, NE, USA
    Atherosclerosis 157:41-7. 2001
    ..We evaluated the effect of a maternal atherogenic diet on atherosclerosis development in offspring...
  16. ncbi Endogenous p53 protects vascular smooth muscle cells from apoptosis and reduces atherosclerosis in ApoE knockout mice
    John Mercer
    Division of Cardiovascular Medicine, University of Cambridge, PO Box 110, Addenbrooke s Hospital, Cambridge, CB2 2QQ, UK
    Circ Res 96:667-74. 2005
    ..We conclude that endogenous levels of p53 protect VSMCs and stromal cells against apoptosis, while promoting apoptosis in macrophages, and protect against atherosclerosis development...
  17. ncbi Effect of atorvastatin on intracellular calcium uptake in coronary smooth muscle cells from diabetic pigs fed an atherogenic diet
    B J Hill
    Department of Physiology, School of Medicine, University of Missouri, MA415 Medical Sciences Building, Columbia, MO 65212, USA
    Atherosclerosis 159:117-24. 2001
    ..In summary, this study demonstrates that atorvastatin prevents the enhanced uptake of Ca(2+) by SR and non-SR Ca(2+) stores in diabetic dyslipidemic pigs...
  18. ncbi The effect of ethanol extract of Hypericum lysimachioides on lipid profile in hypercholesterolemic rabbits and its in vitro antioxidant activity
    Fidan Hakimoğlu
    University of Dicle, Faculty of Science and Art, Chemistry Department, 21280 Diyarbakir, Turkey
    Atherosclerosis 192:113-22. 2007
    ..Antioxidative activities of ethanol extract of HL was found to be comparable with Vitamin E. In conclusion, the use of this extract could be useful in the management of cardiovascular disease in which atherosclerosis is important...
  19. ncbi Regulation of cholesterol 7alpha-hydroxylase mRNA expression in C57BL/6 mice fed an atherogenic diet
    Hitoshi Ando
    Division of Clinical Pharmacology, Department of Pharmacology, Jichi Medical School, Tochigi 329 0498, Japan
    Atherosclerosis 178:265-9. 2005
    ..the following five diets for 2 weeks: a standard diet, cholic acid, cholesterol, cholesterol+high fat, or an atherogenic diet (cholic acid+cholesterol+high fat)...
  20. ncbi Walnuts reduce aortic ET-1 mRNA levels in hamsters fed a high-fat, atherogenic diet
    Paul Davis
    Department of Nutrition, University of California, Davis, CA 95616, USA
    J Nutr 136:428-32. 2006
    ..Finally, the results indicate that the walnut fat compartment is a likely location for the components responsible for the reduced aortic CE concentration...
  21. ncbi Phenolics from purple grape, apple, purple grape juice and apple juice prevent early atherosclerosis induced by an atherogenic diet in hamsters
    Kelly Decorde
    EA 4188 Nutrition Humaine, Biodisponibilité et Athérogénèse, Universite Montpellier 1 and 2, Montpellier, France
    Mol Nutr Food Res 52:400-7. 2008
    ..Five groups of eight hamsters each were fed an atherogenic diet for 12 wk. They received daily by gavage either 7...
  22. ncbi Cholesterol and cholate components of an atherogenic diet induce distinct stages of hepatic inflammatory gene expression
    Laurent Vergnes
    Departments of Medicine and Human Genetics, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 278:42774-84. 2003
    ....
  23. ncbi Fenugreek seeds reduce atherogenic diet-induced cholesterol gallstone formation in experimental mice
    R L R Reddy
    Department of Biochemistry and Nutrition, Central Food Technological Research Institute, CSIR, Mysore 570 020, India
    Can J Physiol Pharmacol 87:933-43. 2009
    ..77-0.99 in fenugreek treatments compared with 2.57 in the high-cholesterol group. Thus, fenugreek seed offers health-beneficial antilithogenic potential by virtue of its favourable influence on cholesterol metabolism...
  24. ncbi Dietary resveratrol alters lipid metabolism-related gene expression of mice on an atherogenic diet
    Jiyun Ahn
    Food Function Research Center, Korea Food Research Institute, 516, Bundang, Gyeonggi 463 746, Republic of Korea
    J Hepatol 49:1019-28. 2008
    ..The aim of the present study is to test whether resveratrol protects against metabolic steatohepatitis through the modulation of lipid metabolism-related genes...
  25. pmc Immune-deficient mice develop typical atherosclerotic fatty streaks when fed an atherogenic diet
    A I Fyfe
    Department of Medicine, University of California, Los Angeles 90024
    J Clin Invest 94:2516-20. 1994
    ..These data indicate that the classical immune system, while not essential for atherosclerotic fatty streak development, may act to suppress the development of lesions...
  26. ncbi Role of group II secretory phospholipase A2 in atherosclerosis: 1. Increased atherogenesis and altered lipoproteins in transgenic mice expressing group IIa phospholipase A2
    B Ivandic
    Department of Microbiology and Molecular Genetics and Molecular Biology Institute, Division of Cardiology, University of California, Los Angeles 90095, USA
    Arterioscler Thromb Vasc Biol 19:1284-90. 1999
    ..These data also provide a possible mechanism for the observation that there is an increased incidence of coronary artery disease in many chronic inflammatory diseases...
  27. ncbi Macrophage-expressed group IIA secretory phospholipase A2 increases atherosclerotic lesion formation in LDL receptor-deficient mice
    Nancy R Webb
    Department of Internal Medicine, University of Kentucky Medical Center MN520, 800 Rose St, Lexington, KY 40536 0084, USA
    Arterioscler Thromb Vasc Biol 23:263-8. 2003
    ..In the present study, we show for the first time that elicited peritoneal macrophages from transgenic mice express human group IIA sPLA(2). This study tested whether macrophage-expressed sPLA(2) contributes to atherogenesis...
  28. pmc Complex genetic control of HDL levels in mice in response to an atherogenic diet. Coordinate regulation of HDL levels and bile acid metabolism
    D Machleder
    Department of Medicine, University of California, Los Angeles 90095, USA
    J Clin Invest 99:1406-19. 1997
    ..Furthermore, we observed that two of the loci for C7AH expression contributed to differences in gallstone formation between these strains...
  29. ncbi Hazelnut oil administration reduces aortic cholesterol accumulation and lipid peroxides in the plasma, liver, and aorta of rabbits fed a high-cholesterol diet
    Aydan Hatipoglu
    Department of Biochemistry, Istanbul Faculty of Medicine, University of Istanbul, 34093 Capa Istanbul, Turkey
    Biosci Biotechnol Biochem 68:2050-7. 2004
    ..HO did not alter the antioxidant system in the liver in the HC group. Our findings indicate that HO reduced oxidative stress and cholesterol accumulation in the aortas of rabbits fed an HC diet...
  30. ncbi Virgin olive and fish oils enhance the hepatic antioxidant defence system in atherosclerotic rabbits
    C M Aguilera
    Department of Biochemistry and Molecular Biology University of Granada, C Ramón y Cajal 4 18071 Granada, Spain
    Clin Nutr 22:379-84. 2003
    ..In this study we report the effects of sunflower, virgin olive and fish oils on the lipid profile and antioxidant defence system in liver mitochondria from rabbits with experimental atherosclerosis...
  31. ncbi Effects of atherogenic diet and atorvastatin treatment on gene expression profiles in the C57BL/6J mouse liver
    Yulan Zhao
    Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Gene Expr 14:149-58. 2008
    This study investigated the early and long-term effects of atherogenic diet on hepatic gene expression, and the restorative effects of atorvastatin in treating hypercholesterolemia...
  32. ncbi Anti-atherogenic effects of the aqueous extract of rhubarb in rats fed an atherogenic diet
    Mi Kyoung Moon
    Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk, 570 749, Republic of Korea
    Am J Chin Med 36:555-68. 2008
    ..the development of atherosclerosis through regulating vascular inflammatory processes in rats fed with an atherogenic diet. AR significantly reduced plasma low-density lipoprotein-cholesterol, and increased plasma high-density ..
  33. doi Replacing dietary carbohydrate with protein and fat decreases the concentrations of small LDL and the inflammatory response induced by atherogenic diets in the guinea pig
    Matthew J Sharman
    Centre of Excellence for Alzheimer s Disease Research and Care, Edith Cowan University, Joondalup WA 6027, Australia
    J Nutr Biochem 19:732-8. 2008
  34. ncbi Phycobiliprotein C-phycocyanin from Spirulina platensis is powerfully responsible for reducing oxidative stress and NADPH oxidase expression induced by an atherogenic diet in hamsters
    Jérome Riss
    EA 4188, Nutrition Humaine, Biodisponibilité et Athérogénèse, Place E Bataillon, Universite Montpellier 1 and 2, 34095 Montpellier, France
    J Agric Food Chem 55:7962-7. 2007
    ..Forty hamsters were divided into 5 groups of 8 and fed an atherogenic diet for 12 weeks. They received by gavage either 7...
  35. ncbi Cell composition, replication, and apoptosis in atherosclerotic plaques after 6 months of cholesterol withdrawal
    M M Kockx
    Department of Pathology, A Z Middelheim, Antwerp, Belgium
    Circ Res 83:378-87. 1998
    ..Moreover, the expression of the proapoptotic factor, BAX, was reduced in the remaining cells, which were mainly SMCs. These findings could help to explain the benefit of lipid-lowering therapy on plaque stabilization...
  36. ncbi A fibre cocktail of fenugreek, guar gum and wheat bran reduces oxidative modification of LDL induced by an atherogenic diet in rats
    Nandini Venkatesan
    Vaccine Research and Development Center, National Health Research Institutes, Miaoli County, Taiwan, ROC
    Mol Cell Biochem 294:145-53. 2007
    ..This study was undertaken to evaluate the influence of a novel fibre mix of fenugreek seed powder, guar gum and wheat bran (Fibernat) on LDL oxidation induced by an atherogenic diet.
  37. ncbi The reversal of the inhibition on lipids synthesis by L-659,699 in arterial smooth muscle cells cultures
    A Carazo
    Department of Biochemistry and Molecular Biology, Faculty of Sciences, University of Granada, Spain
    Mol Cell Biochem 221:25-31. 2001
    ..The effect of inhibitor is stronger in young cultures (3-4 steps) than in the older ones (11-12 steps). In young C-SMC and Ch-SMC cultures the inhibition of cholesterol and triacylglycerides synthesis by L-659,699 was reversal...
  38. ncbi Effects of conjugated linoleic acid on body fat accumulation and serum lipids in hamsters fed an atherogenic diet
    V Navarro
    Department of Nutrition and Food Science, University of the Basque Country, Paseo de la Universidad 7, 01006 Vitoria, Spain
    J Physiol Biochem 59:193-9. 2003
    ..effects of c-9,t-11 and t-10,c-12 CLA isomers on body fat accumulation and serum lipids in hamsters fed an atherogenic diet. Hamsters were divided in four groups: one group was fed a chow diet (control) and the other three groups ..
  39. ncbi In vivo antiatherogenic properties of olive oil and its constituent lipid classes in hyperlipidemic rabbits
    Haralabos C Karantonis
    Laboratory of Biochemistry, Faculty of Chemistry, National and Kapodistrian University of Athens, Panepistimioupolis, Greece
    Nutr Metab Cardiovasc Dis 16:174-85. 2006
    ....
  40. ncbi Hypolipidemic activity of Eclipta prostrata (L.) L. leaf extract in atherogenic diet induced hyperlipidemic rats
    R Dhandapani
    Medicinal Plants Research Unit, P G and Research Department of Microbiology, Thanthai Hans Roever College, Perambalur 621 212, India
    Indian J Exp Biol 45:617-9. 2007
    In atherogenic diet induced hyperlipidemic model, the rats receiving treatment with the aqueous extract of the leaves of E...
  41. ncbi Gallic acid antagonizes P-selectin-mediated platelet-leukocyte interactions: implications for the French paradox
    Chantal C M Appeldoorn
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Leiden University, Gorlaeus Laboratories, Leiden, The Netherlands
    Circulation 111:106-12. 2005
    ....
  42. ncbi Effects of hyperfibrinogenemia on vasculature of C57BL/6 mice with and without atherogenic diet
    Alyssa A Gulledge
    Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill 27599 7525, USA
    Arterioscler Thromb Vasc Biol 23:130-5. 2003
    ..To study this relationship, we examined spontaneous and diet-induced atherosclerosis in transgenic mice with hyperfibrinogenemia (elevated fibrinogen)...
  43. ncbi trans-10,cis-12 conjugated linoleic acid prevents adiposity but not insulin resistance induced by an atherogenic diet in hamsters
    Edurne Simón
    Department of Nutrition and Food Science, Faculty of Pharmacy, University of the Basque Country, Paseo de la Univrsidad, 7, 01006 Vitoria, Spain
    J Nutr Biochem 17:126-31. 2006
    ..work was to analyse the effects of trans-10,cis-12 CLA isomer on insulin sensitivity in hamsters fed an atherogenic diet. Hamsters were divided into three groups: one group was fed a chow diet (control) and the other two a ..
  44. ncbi Green tea catechins, alleviate hepatic lipidemic-oxidative injury in Wistar rats fed an atherogenic diet
    E Ramesh
    Department of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli, Tamil Nadu, India
    Chem Biol Interact 180:10-9. 2009
    ..When male albino Wistar rats were fed an atherogenic diet for 30 days and then treated with saline for 7 or 15 days, there was a significant decline in hepatic mean ..
  45. ncbi Morphologic and electroretinographic phenotype of SR-BI knockout mice after a long-term atherogenic diet
    Alexandra C Provost
    Universite Paris Descartes, Faculté de Médecine Paris Descartes site Necker, Centre de Recherche Thérapeutique en Ophtalmologie, EA 2502 CERTO, AP HP Assistance Publique Hôpitaux de Paris, Paris, France
    Invest Ophthalmol Vis Sci 50:3931-42. 2009
    ..To evaluate functional and ultrastructural changes in the retina of scavenger receptor B1 (SR-BI) knockout (KO) mice consuming a high fat cholate (HFC) diet...
  46. ncbi Possible amelioration of atherogenic diet induced dyslipidemia, hypothyroidism and hyperglycemia by the peel extracts of Mangifera indica, Cucumis melo and Citrullus vulgaris fruits in rats
    Hamendra Singh Parmar
    Endocrine Research Unit, Devi Ahilya University, Indore, MP, India
    Biofactors 33:13-24. 2008
    ..In the second experiment rats were maintained on pre-standardized atherogenic diet CCT (supplemented with 4% cholesterol, 1% cholic acid and 0...
  47. ncbi Atherogenic diet-induced hepatitis is partially dependent on murine TLR4
    Moreshwar S Desai
    Pediatric Critical Care Medicine, Baylor College of Medicine, Houston, TX 77030 2600, USA
    J Leukoc Biol 83:1336-44. 2008
    ..TLR2 deletion had no effect on diet-induced hepatitis but increased the amount of steatosis. We conclude that the early inflammatory liver injury but not hepatic lipid loading induced by the ATH diet in mice is mediated in part by TLR4...
  48. ncbi In vivo electrotransfer of interleukin-10 cDNA prevents endothelial upregulation of activated NF-kappaB and adhesion molecules following an atherogenic diet
    Stéphane Potteaux
    Centre de Recherche Cardiovasculaire Inserm Lariboisiere, U689, Paris
    Eur Cytokine Netw 17:13-8. 2006
    ..However, the molecular mechanisms involved in IL-10 protection against atherosclerosis in vivo remain poorly understood. In this study, we examined the effect of IL-10 cDNA in vivo electrotransfer on diet-induced, endothelial activation...
  49. ncbi Supplementation of plant sterols and minerals benefits obese Zucker rats fed an atherogenic diet
    Timo Vaskonen
    Institute of Biomedicine, Pharmacology, University of Helsinki, Finland
    J Nutr 132:231-7. 2002
    ..Supplementation of this atherogenic diet with plant sterols (1 g/100 g) and replacing the NaCl partially by calcium, magnesium and potassium ..
  50. ncbi Mechanism of dystrophic calcification in rabbit aortas: temporal and spatial distributions of calcifying vesicles and calcification-related structural proteins
    Howard H T Hsu
    Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160 7410, USA
    Cardiovasc Pathol 13:3-10. 2004
    ..Whether the distributions of other structural proteins related to calcification such as collagen and elastin fibers undergo coordinated modifications has not been established...
  51. pmc Effects of dietary calcium on atherosclerosis, aortic calcification, and icterus in rabbits fed a supplemental cholesterol diet
    Howard H T Hsu
    Department of Pathology and Laboratory Medicine, Cardiovascular Research Division, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Lipids Health Dis 5:16. 2006
    ....
  52. ncbi [Advanced glycation end products accelerate atherosclerosis via enhancement of oxidative stress]
    Wei Ru Zhang
    Department of Nephrology, Nanfang Hospital, Guangzhou 510515, China
    Zhonghua Yi Xue Za Zhi 84:1066-72. 2004
    ..To investigate the effect of advanced glycation end products (AGE) on atheromatous plaque formation and its possible mechanisms...
  53. ncbi Genetic deletion of tissue-type plasminogen activator (t-PA) in APOE3-Leiden mice reduces progression of cholesterol-induced atherosclerosis
    Farhad Rezaee
    Department of Vascular and Connective Tissue Research, Gaubius Laboratory, TNO PG, Leiden, The Netherlands
    Thromb Haemost 90:710-6. 2003
    ..offspring was used to evaluate the progression of atherosclerotic lesions after they were fed a variant atherogenic diet for 12 weeks...
  54. ncbi Atorvastatin has hypolipidemic and anti-inflammatory effects in apoE/LDL receptor-double-knockout mice
    Petr Nachtigal
    Department of Biological and Medical Sciences, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Heyrovskeho 1203, Hradec Kralove 500 05, Czech Republic
    Life Sci 82:708-17. 2008
    ..The control group of animals (n=8) was fed with the western type diet (atherogenic diet) and in other two groups atorvastatin was added to the atherogenic diet at the dosage of either 10 mg/kg or ..
  55. ncbi Effects of flaxseed oil on serum lipids and atherosclerosis in hypercholesterolemic rabbits
    Paul Lee
    Department of Physiology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    J Cardiovasc Pharmacol Ther 8:227-35. 2003
    ....
  56. ncbi A comparative study of efficacy of tibolone and simvastatin on atherosclerosis in ovariectomized cholesterol-fed rabbits
    Yali Cui
    College of Veterinary Medicine, China Agriculture University, Beijing 100094, China
    Maturitas 50:337-43. 2005
    ..The present study investigated the effect of tibolone and simvastatin on atherosclerosis and the expression of both estrogen receptor A (ERA) and LDL receptor (LDLR) mRNA in ovariectomized cholesterol-fed rabbits...
  57. ncbi Harmful effects of increased LDLR expression in mice with human APOE*4 but not APOE*3
    Sudi I Malloy
    Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill 27599, USA
    Arterioscler Thromb Vasc Biol 24:91-7. 2004
    ....
  58. ncbi Molecular imaging of atherosclerotic plaques using a human antibody against the extra-domain B of fibronectin
    Christian M Matter
    Cardiovascular Research, Institute of Physiology, University of Zurich and Cardiovascular Center, Zurich University Hospital, Switzerland
    Circ Res 95:1225-33. 2004
    ..Thus, our findings may set the stage for antibody-based molecular imaging of atherosclerotic plaques in the intact organism...
  59. ncbi Inhibition of sphingomyelin synthesis reduces atherogenesis in apolipoprotein E-knockout mice
    Tae Sik Park
    Cardiovascular Pharmacology, Pfizer Global Research and Development, Ann Arbor, Mich 48105, USA
    Circulation 110:3465-71. 2004
    ..To test this hypothesis, apolipoprotein E (apoE)-knockout (KO) mice were treated with myriocin, a potent inhibitor of serine palmitoyltransferase, the rate-limiting enzyme in SM biosynthesis...
  60. ncbi Temporal relationships between circulating levels of CC and CXC chemokines and developing atherosclerosis in apolipoprotein E*3 Leiden mice
    Nuala Murphy
    Department of Biochemistry and Molecular Biology, Royal Free and University College Medical School of UCL, London, UK
    Arterioscler Thromb Vasc Biol 23:1615-20. 2003
    ..Serum chemokine concentrations were measured in apolipoprotein (apo) E*3 Leiden mice and their nontransgenic littermates and related to the differing rates of atherogenesis in these animals...
  61. pmc Activation of heat shock transcription factor 1 in atherosclerosis
    Bernhard Metzler
    Department of Internal Medicine, Division of Cardiology, University Hospital of Innsbruck, Innsbruck, Austria
    Am J Pathol 162:1669-76. 2003
    ..Thus, our findings provide the first evidence that HSF1 is activated and highly expressed in atherosclerotic lesions and that cytokine stimulation and disturbed mechanical stress to the vessel wall may be responsible for such activation...
  62. ncbi Inhibition of atherosclerosis in apoE-null mice by immunization with apoB-100 peptide sequences
    Gunilla Nordin Fredrikson
    Department of Medicine, Malmo University Hospital, Lund University, Malmo, Sweden
    Arterioscler Thromb Vasc Biol 23:879-84. 2003
    ..Immunization of animals with oxidized LDL results in reduction of atherosclerosis, suggesting an atheroprotective effect of this immune response...
  63. ncbi Mouse strain-specific differences in vascular wall gene expression and their relationship to vascular disease
    Raymond Tabibiazar
    Donald W Reynolds Cardiovascular Clinical Research Center, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Arterioscler Thromb Vasc Biol 25:302-8. 2005
    ..In this study, we sought to identify the genetic pathways that are differentially activated in the aortas of these mice...
  64. ncbi Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesis
    Romeo Ricci
    Cardiovascular Research, Institute of Physiology, and Division of Cardiology, University Hospital Zurich, CH 8057 Zurich, Switzerland
    Science 306:1558-61. 2004
    ..Thus, JNK2-dependent phosphorylation of SR-A promotes uptake of lipids in macrophages, thereby regulating foam cell formation, a critical step in atherogenesis...
  65. ncbi Cholesteryl ester transfer protein inhibitor (JTT-705) and the development of atherosclerosis in rabbits with severe hypercholesterolaemia
    Zhiping Huang
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University, Takara machi 13 1, Kanazawa 920 8641, Japan
    Clin Sci (Lond) 103:587-94. 2002
    ....
  66. ncbi Genetic ablation of caveolin-1 confers protection against atherosclerosis
    Philippe G Frank
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Golding 202, Bronx, NY 10461, USA
    Arterioscler Thromb Vasc Biol 24:98-105. 2004
    ..Here, we evaluate the potential role of caveolae membrane domains in the pathogenesis of atherosclerosis by using apolipoprotein E-deficient (ApoE-/-) mice as a model system...
  67. ncbi A diet-induced hypercholesterolemic murine model to study atherogenesis without obesity and metabolic syndrome
    Karsten Hartvigsen
    Department of Medicine, 0682, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0682, USA
    Arterioscler Thromb Vasc Biol 27:878-85. 2007
    ..Our aim was to design a diet inducing atherosclerosis through moderate hypercholesterolemia without associated parameters of the metabolic syndrome...
  68. ncbi Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice
    Nicholas J Alp
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Arterioscler Thromb Vasc Biol 24:445-50. 2004
    ..We aimed to investigate the importance of endothelial BH4 availability in atherosclerosis using a transgenic mouse model with endothelial-targeted overexpression of the rate-limiting enzyme in BH4 synthesis, GTP-cyclohydrolase I (GTPCH)...
  69. ncbi Effect of trans-resveratrol on the thrombogenicity and atherogenicity in apolipoprotein E-deficient and low-density lipoprotein receptor-deficient mice
    Hideharu Fukao
    Department of Nutritional Science, Faculty of Food Culture, Kurashiki Sakuyo University, 3515 Nagao, Tamashima, Kurashiki City, Okayama, 710 0292 Japan
    Blood Coagul Fibrinolysis 15:441-6. 2004
    ..Thus, t-RES orally administrated with a high-fat diet in apoE-/-/LDLR-/- mice significantly suppressed atherosclerosis in their aortae and reduced the laser-induced thrombosis in their carotid arteries...
  70. ncbi Inhibition of diet-induced atherosclerosis and endothelial dysfunction in apolipoprotein E/angiotensin II type 1A receptor double-knockout mice
    Sven Wassmann
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Circulation 110:3062-7. 2004
    ..Angiotensin II type 1 (AT1) receptor activation is potentially involved in the multifactorial pathogenesis of atherosclerosis...
  71. ncbi Increase in serum amyloid a evoked by dietary cholesterol is associated with increased atherosclerosis in mice
    Katherine E Lewis
    Department of Medicine, University of Washington, Seattle, Wash 98195 6426, USA
    Circulation 110:540-5. 2004
    ..Therefore, we hypothesized that diet-induced increases in SAA would increase atherosclerosis independent of their effect on plasma cholesterol levels...
  72. ncbi Effects of eggplant (Solanum melongena) on the atherogenesis and oxidative stress in LDL receptor knock out mice (LDLR(-/-))
    Françoise V Botelho
    Departamento de Bioquimica e Imunologia, ICB, Universidade Federal de Minas Gerais, Caixa Postal 486, 30 161 970, Belo Horizonte MG, Brazil
    Food Chem Toxicol 42:1259-67. 2004
    ..Surprisingly, eggplant increased oxidative stress, representing a risk factor for atherosclerosis. These results did not support the use of eggplant extract as hypocholesterolemic agent...
  73. ncbi Application of stereological methods for the quantification of VCAM-1 and ICAM-1 expression in early stages of rabbit atherogenesis
    Petr Nachtigal
    Department of Biological and Medical Sciences, Faculty of Pharmacy, Charles University in Prague, Heyrovskeho 1203, Hradec Kralove 500 05, Czech Republic
    Pathol Res Pract 200:219-29. 2004
    ..Stereological methods proved to be useful for the quantification of immunohistochemistry and can be used for an objective characterization of atherogenic changes in atherosclerosis...
  74. ncbi Endothelial overexpression of Fas ligand decreases atherosclerosis in apolipoprotein E-deficient mice
    Jiang Yang
    Department of Molecular Cardiology, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Mass 02118 2526, USA
    Arterioscler Thromb Vasc Biol 24:1466-73. 2004
    ..Fas ligand (FasL) can induce apoptosis in cells bearing the Fas receptor. The role of FasL in the vasculature with regard to atherosclerosis is controversial. This study examined the function of endothelial FasL during atherosclerosis...
  75. ncbi Effect of a taurine treatment on the regression of existing atherosclerotic lesions in rabbits fed on a high-cholesterol diet
    Jale Balkan
    Department of Biochemistry, Istanbul Faculty of Medicine, Istanbul University, Capa Istanbul, Turkey
    Biosci Biotechnol Biochem 68:1035-9. 2004
    ..These results indicate that the taurine treatment may accelerate the regression of cholesterol-induced atherosclerotic lesions in rabbits without having any effect on the plasma and aorta lipid and lipid peroxide levels...
  76. ncbi Development of aortic valve sclerosis in a rabbit model of atherosclerosis: an immunohistochemical and histological study
    Massimo Cimini
    University of Western Ontario, Department of Anatomy and Cell Biology, Canada
    J Heart Valve Dis 14:365-75. 2005
    ..Cellular, structural and morphological changes in the aortic valves of these rabbits were studied...
  77. ncbi Effect of macrophage-derived apolipoprotein E on hyperlipidemia and atherosclerosis of LDLR-deficient mice
    Weibin Shi
    Department of Radiology, University of Virginia, Charlottesville 22908, USA
    Biochem Biophys Res Commun 317:223-9. 2004
    ..56; P<0.0001). Thus, macrophage apoE-deficiency alleviates severe hyperlipidemia by slowing hepatic VLDL production and consequently reduces atherosclerosis in LDLR(-/-) mice...
  78. ncbi Differential effects of apolipoprotein A-I-mimetic peptide on evolving and established atherosclerosis in apolipoprotein E-null mice
    Xiaojun Li
    Atherosclerosis Research Center, Division of Cardiology, Department of Medicine and Burns and Allen Research Institute, Cedars Sinai Medical Center and David Geffen School of Medicine at UCLA, Los Angeles, Calif 90048, USA
    Circulation 110:1701-5. 2004
    ....
  79. ncbi Plasma cholesteryl esters provided by lecithin:cholesterol acyltransferase and acyl-coenzyme a:cholesterol acyltransferase 2 have opposite atherosclerotic potential
    Richard G Lee
    Arteriosclerosis Research Program, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Circ Res 95:998-1004. 2004
    ..Overall, the data suggest that ACAT2-derived CE is the predominant atherogenic lipid in blood, and that an important goal for prevention of atherosclerosis is to limit ACAT2-derived CE accumulation in lipoproteins...
  80. ncbi Plaque rupture after short periods of fat feeding in the apolipoprotein E-knockout mouse: model characterization and effects of pravastatin treatment
    Jason Johnson
    Bristol Heart Institute, University of Bristol, Bristol, United Kingdom
    Circulation 111:1422-30. 2005
    ....
  81. ncbi Murine cytomegalovirus infection increases aortic expression of proatherosclerotic genes
    Mary Susan Burnett
    Cardiovascular Research Institute, MedStar Research Institute, Washington Hospital Center, Washington, DC 20010, USA
    Circulation 109:893-7. 2004
    ..Additionally, in cholesterol-fed C57BL/6J mice, we examined the effects of MCMV infection on aortic lesion area...
  82. ncbi A new model to evaluate the diet-induced prothrombotic state, using He-Ne laser-induced thrombogenesis in the carotid artery of apolipoprotein E-deficient and low-density lipoprotein receptor-deficient mice
    Y Ijiri
    Laboratory of Physiology, Faculty of Nutrition, and High Technology Research Center, Kobe Gakuin University, Japan
    Blood Coagul Fibrinolysis 13:497-504. 2002
    ..These diets were on the basis of AIN93G and were given to mice for 4 or 8 weeks. The high fat diet significantly enhanced both the thrombotic reaction and the development of atherosclerosis as compared with the low fat diet...
  83. ncbi IFN-gamma deficiency exerts gender-specific effects on atherogenesis in apolipoprotein E-/- mice
    Stewart C Whitman
    University of Ottawa Heart Institute, Ottawa, Ontario, Canada, K1Y 4W7
    J Interferon Cytokine Res 22:661-70. 2002
    ..However, this effect is strikingly restricted to male mice...
  84. ncbi Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis
    L Boring
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94141, USA
    Nature 394:894-7. 1998
    ..These data reveal a role for MCP-1 in the development of early atherosclerotic lesions and suggest that upregulation of this chemokine by minimally oxidized lipids is an important link between hyperlipidaemia and fatty streak formation...
  85. ncbi The effects of magnesium sulphate and EDTA in the hypercholesterolaemic rabbit
    D A Evans
    Riyadh Armed Forces Hospital, Riyadh, Kingdom of Saudi Arabia Manfouha Central Hospital Riyadh, Kingdom of Saudi Arabia
    Diabetes Obes Metab 3:417-22. 2001
    ..It is concluded that CHL injections have a definite prophylactic effect on atherogenesis in the cholesterol-fed rabbit, and may have some therapeutic value in the regression phase. Further confirmatory studies are suggested...
  86. ncbi Effect of hypercholesterolemia on expression and function of vascular soluble guanylyl cyclase
    Ute Laber
    Institut fur Pharmakologie und Klinische Pharmakologie, Heinrich Heine Universitat, Dusseldorf, Germany
    Circulation 105:855-60. 2002
    ..Vasorelaxation to endothelial NO is mediated by activation of soluble guanylyl cyclase (sGC) and impaired by hypercholesterolemia in animals and humans. We investigated whether hypercholesterolemia impacts expression and function of sGC...
  87. pmc Gene expression in atherosclerotic lesion of ApoE deficient mice
    D M Wuttge
    Center for Molecular Medicine, Department of Medicine, Karolinska Hospital, Stockholm, Sweden
    Mol Med 7:383-92. 2001
    ..Thus, detailed evaluation of gene expression at several time points should help understanding the development of atherosclerosis and establishment of preventive intervention...
  88. ncbi Effects of heterozygous lipoprotein lipase deficiency on diet-induced atherosclerosis in mice
    C F Semenkovich
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Lipid Res 39:1141-51. 1998
    ..To address the role of LPL in atherosclerosis, LPL+/- mice in the C57BL/6J background were fed an atherogenic diet for 8 months...
  89. ncbi Lecithin:cholesterol acyltransferase deficiency increases atherosclerosis in the low density lipoprotein receptor and apolipoprotein E knockout mice
    James W Furbee
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, North Carolina 27157 1040, USA
    J Biol Chem 277:3511-9. 2002
    ..After 16 weeks of atherogenic diet (0...
  90. ncbi Extracellular superoxide dismutase deficiency and atherosclerosis in mice
    M L Sentman
    Department of Medical Biosciences, Clinical Chemistry, Umea University Hospital, Umea, Sweden
    Arterioscler Thromb Vasc Biol 21:1477-82. 2001
    ..On an apolipoprotein E-null background, the limited aortic lesions induced by a 1-month atherogenic diet were larger in EC-SOD wild-type mice than in EC-SOD-null mice, whereas there were no differences between the ..
  91. ncbi Lipid peroxidation and platelet activation in murine atherosclerosis
    T Cyrus
    Center for Experimental Therapeutics, Department of Pharmacology, University of Pennsylvania, Philadelphia, USA
    Circulation 104:1940-5. 2001
    ..Lipid peroxidation and platelet activation are thought to be important contributors to the pathogenesis of atherosclerosis. The relevance of their interaction in vivo, however, is unknown...
  92. pmc Role of macrophage colony-stimulating factor in atherosclerosis: studies of osteopetrotic mice
    J H Qiao
    Department of Medicine, Molecular Biology Institute, University of California, Los Angeles, USA
    Am J Pathol 150:1687-99. 1997
    ..The effects of the op mutation on atherogenesis may have resulted from decreased circulating monocytes, reduced tissue macrophages, or diminished arterial M-CSF...
  93. ncbi 12/15-Lipoxygenase gene disruption attenuates atherogenesis in LDL receptor-deficient mice
    J George
    Institute of Lipid and Atherosclerosis Research, Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Circulation 104:1646-50. 2001
    ..Previous in vivo tests of the role of LOs in atherogenesis animal models, however, have yielded conflicting results...
  94. ncbi Immunopathogenesis of atherosclerosis: endotoxin accelerates atherosclerosis in rabbits on hypercholesterolemic diet
    H A Lehr
    Institute of Pathology, University of Mainz, Germany
    Circulation 104:914-20. 2001
    ..These data support the concept that atherosclerosis has an immunopathological component and render it improbable that a single infectious agent should assume particular importance in its initiation or progression...
  95. ncbi Lack of apoA-I is not associated with increased susceptibility to atherosclerosis in mice
    H Li
    Department of Pathology, University of North Carolina, Chapel Hill 27599 7525
    Arterioscler Thromb 13:1814-21. 1993
    ..After being maintained on an atherogenic diet for 4 weeks, total plasma cholesterol of the homozygous mutants increased by 20 mg/dL, while that of normals ..
  96. ncbi Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice
    L Gu
    Department of Adult Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Mol Cell 2:275-81. 1998
    ..Thus, MCP-1 plays a unique and crucial role in the initiation of atherosclerosis and may provide a new therapeutic target in this disorder...
  97. ncbi Expression of LR11, a mosaic LDL receptor family member, is markedly increased in atherosclerotic lesions
    T Kanaki
    Second Department of Internal Medicine, School of Medicine, Chiba University, Japan
    Arterioscler Thromb Vasc Biol 19:2687-95. 1999
    ....
  98. ncbi Reduction of isoprostanes and regression of advanced atherosclerosis by apolipoprotein E
    R K Tangirala
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 276:261-6. 2001
    ..In summary, these results demonstrate that liver-derived apoE directly induced regression of advanced atherosclerosis and has anti-oxidant properties in vivo that may contribute to its anti-atherogenic effects...
  99. ncbi ICAM-1 deficiency reduces atherosclerotic lesions in double-knockout mice (ApoE(-/-)/ICAM-1(-/-)) fed a fat or a chow diet
    M C Bourdillon
    INSERM U331 Faculté de Médecine RTH Laënnec, Lyon, France
    Arterioscler Thromb Vasc Biol 20:2630-5. 2000
    ..Plasma cholesterol levels were not altered as a result of ICAM-1 deficiency. These studies show that ICAM-1 is implicated in the formation and progression of atherosclerotic lesions...
  100. pmc LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes
    B A Laffitte
    Howard Hughes Medical Institute, Department of Pathology, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 98:507-12. 2001
    ..Together with our previous work, these findings support a central role for LXR signaling pathways in the control of macrophage cholesterol efflux through the coordinate regulation of apoE, ABCA1, and ABCG1 expression...
  101. ncbi Protection against atherosclerosis by estrogen is independent of plasma cholesterol levels in LDL receptor-deficient mice
    M M Marsh
    Department of Immunology, The Scripps Research Institute, La Jolla, CA, 92037, USA
    J Lipid Res 40:893-900. 1999
    ..E2 protected LDLR-/- female mice from atherosclerosis and this protection was independent of changes in plasma cholesterol levels...

Research Grants63

  1. Mechanisms of coronary microvascular dysfunction in metabolic syndrome
    Johnathan D Tune; Fiscal Year: 2012
    ..proposed studies will be performed on Ossabaw swine fed a normal maintenance diet (7% kcal from fat) or an atherogenic diet (45% kcal from fat and 2% cholesterol) for 20 weeks...
  2. Macrophage AMPK, Inflammation, and Atherosclerosis
    Bingzhong Xue; Fiscal Year: 2013
    ..stress, inflammation and apoptosis development in early and late atherosclerotic lesions in these mice fed an atherogenic diet. Specific aim 3 will determine the protective effects of macrophage AMPK against insulin resistance using ..
  3. Plasmalogen-derived bioactive lipids in atherosclerosis
    David A Ford; Fiscal Year: 2013
    ..metabolites will also be identified in atherosclerotic tissue and plasma from LDL receptor-/- mice on an atherogenic diet that overexpress human MPO in their macrophages...
  4. Mitogen-activated Protein Kinases and NF-kB Activation in Vascular Smooth Muscle
    Bingbing Jiang; Fiscal Year: 2010
    ..selected inflammatory events and atherogenesis in wild type and I:B1 knock-out/I:B2 knock-in mice on an atherogenic diet either with or without angiotensin II infusion...
  5. Inflammation, Atherosclerosis and ApoA-I
    Mary G Sorci-Thomas; Fiscal Year: 2013
    ..deposition, accelerated atherosclerosis and the development of an autoimmune phenotype in response to an atherogenic diet in LDL receptor, apoA-Idouble knockout (DKO) mice...
  6. Macrophage, ABCA1, Inflammation, and Atherosclerosis
    John S Parks; Fiscal Year: 2012
    ..macrophage number, lipid content, and gene expression, and 5) effect on MSKO-LDLrKO and LDLrKO mice fed an atherogenic diet. In Specific aim 3, our preliminary data demonstrated that MSKO mice fed a high fat/high sucrose (HF/HS) diet ..
  7. Green Tea Nanocarriers: A Promising Approach for the Prevention and Treatment of
    Shu Wang; Fiscal Year: 2011
    ..To determine the effects of CSNLC-EGCG on atherosclerosis in vivo, LDL receptor null mice will receive an atherogenic diet for 20 weeks...
  8. Effects of Oxidized Low-density Lipoprotein on Bone Marrow Stem Cell
    Zhenguo Liu; Fiscal Year: 2013
    ..and quantitatively analyzed from both hyperlipidemic male LDL receptor knock out (LDLR-/-) mice (with atherogenic diet) and ox-LDL-infused wild-type (WT) normal C57BL/6 mice...
  9. Development of a Novel RA/Atherosclerosis Mouse Model
    HARRIS R PERLMAN; Fiscal Year: 2013
    ..arthritis beginning at 4-5 weeks of age followed by severe aortic atherosclerosis when receiving an atherogenic diet. Thus, for the first time, we introduce a mouse model that faithfully recapitulates both human diseases...
  10. Arginase II, A Novel Target in Atherosclerosis
    Lewis H Romer; Fiscal Year: 2013
    ..In the fourth aim, an atherogenic diet in genetically hypercholesterolemic (ApoE-/-) mice will be used to evaluate the consequences of inhibiting ..
  11. H2 haplotype and atherosclerosis
    Weibin Shi; Fiscal Year: 2013
    ..developing much smaller lesions than C57BL/6 (B6) mice when deficient in apolipoprotein E (apoE-/-) or fed an atherogenic diet. The two strains differ in the H2 haplotype with B6 having H2b and C3H having H2k. C3.SW-H2b/SnJ (C3...
  12. The role of ABCG1 in Atherosclerosis Progression and TH17 Differentiation
    LATEIRA DENISE HAYNES; Fiscal Year: 2013
    ..We have preliminary data that there is increased ROR3t expression in Tregs from ApoE-/- mice fed an atherogenic diet;however ROR3T expression is not increased in ApoE-/- ABCG1-/- mice fed the same diet...
  13. Noninvasive Assessment of Pancreatic Beta-Cell Mass
    Xiankai Sun; Fiscal Year: 2013
    ..The Ossabaw miniature pigs develop type 2 diabetes when placed on an atherogenic diet. PET measures of 68Ga-NOTA-EM2198 uptake will be correlated with the gold standard of pathology assay of ..
  14. Interleukin-19 Inhibits Atherosclerosis by Diverse Mechanisms
    Michael V Autieri; Fiscal Year: 2013
    ..application we present preliminary data showing that addition of recombinant IL-19 to LDLR-/- mice fed an atherogenic diet significantly and dramatically decreases atherosclerotic plaque, and IL-19-/- mice have an exacerbated ..
  15. Angiogenesis in a model of diabetes and endothelial dysfunction
    Frank Sellke; Fiscal Year: 2009
    ..model that mimics many of the abnormalities present in type I diabetic patients, and 2) Ossabaw swine fed an atherogenic diet that will develop a glucose intolerance and insulin resistance similar to type II diabetes...
  16. Ultrasound-induced tissue damage assessment
    WILLIAM D O'BRIEN; Fiscal Year: 2013
    ..when US interacts with UCAs in vivo;2) to determine the US thresholds for arterial damage in post-exposure atherogenic diet-fed NZW rabbits when US interacts with UCAs in vivo;3) to determine the US thresholds for arterial damage in ..
  17. ACTION OF ALCOHOL & QUERCETIN ON ANTI-ATHEROGENIC FACTORS & ATHEROGENESIS
    Raj Lakshman; Fiscal Year: 2007
    ..4. Feeding atherogenic diet for 8 weeks markedly decreased serum and liver PON activity and liver PON mRNA level coupled with extensive ..
  18. THE YUCATAN MICROPIG CARDIOVASCULAR MODEL OF MENOPAUSE
    James Goodrich; Fiscal Year: 2006
    ..will approach this by comparing groups of male, ovariectomized female, and intact female Micropigs fed an atherogenic diet. The end points will be identical to those of the first aim...
  19. VASCULAR/METABOLIC EFFECTS OF REPEAT WEIGHT LOSS/REGAIN
    DIETER KRAMSCH; Fiscal Year: 1992
    ..monkeys) comprising the following groups of animals: 1) normal control monkeys; 2) monkeys on a high calorie-atherogenic diet for 18 months (baseline weight gain/atherosclerosis); 3) maintenance of this high calorie diet for 30 more ..
  20. EXPERIMENTAL OCULAR VASCULAR OCCLUSIVE STUDIES
    SOHAN HAYREH; Fiscal Year: 1992
    ..This has been done for over 10 years now by feeding them a special atherogenic diet. In a proportion of these animals, over the past several years experimental chronic arterial hypertension has ..
  21. Effect of soy isoflavone on cholesterol & SREBP-regulated gene expression.
    Eimear Mullen; Fiscal Year: 2009
    ..We will use the C57BL/6J mouse and feed it an atherogenic diet for either 2 days, 10 days or 6 weeks...
  22. ISOLATION OF A HYPERCHOLESTEROLEMIA RESISTANCE GENE
    Karen Reue; Fiscal Year: 2002
    ..C57BL/6J (J) substrain, which develops hypercholesterolemia and atherosclerotic lesions in response to the atherogenic diet. The Bailey and J substrains exhibit an extremely high degree of genetic identity, with no polymorphisms ..
  23. ATHEROGENESIS AND THE BONE MARROW ANGIOTENSIN SYSTEM
    Carlos Ferrario; Fiscal Year: 2004
    ..and clonogenic assays and identify altered gene expression by array analysis in cynomolgus monkeys fed an atherogenic diet. In Specific Aim 3 they will evaluate whether blockade of the AT1 receptor alters bone marrow myelopoiesis ..
  24. DRUG TREATMENT OF STENOSING PRIMATE ATHEROSCLEROSIS
    DIETER KRAMSCH; Fiscal Year: 1980
    ..peripheral circulation in (1) monkeys on a high butter-cholesterol diet for 18 months, (2) monkeys on this atherogenic diet but treated with 2 different drugs, (3) monkeys on this atherogenic diet for 18 months without drugs followed ..
  25. ALCOHOL EFFECT ON SERUM APOLIPOPROTEINS
    Mark Deeg; Fiscal Year: 2000
    ..LDL receptor gene- knockout (LDLR -/-) mice and apo E-/- mice impeded the early atherosclerosis induced by an atherogenic diet. Furthermore, it showed that feeding the atherogenic diet sharply decreased serum apo A1 in LDLR-/- mice but ..
  26. ARTHEROSCLEROSIS IN INSULIN-RESISTANT, HYPERLIPIDEMIC P*
    David Clemmons; Fiscal Year: 2005
    ..will be determined in CH-IR pigs and compared to CH pigs without IR, both groups being fed a high fat atherogenic diet. A second study will compare these same variables in FH-IR and FH-nonIR pigs fed normal (low fat) pig chow...
  27. Apoj/Clusterin:A Protective Protein In Vascular Biology
    NORMAN GRANHOLM; Fiscal Year: 2005
    ..mice develop increased hypercholesterolemia compared to apoJ wild type mice fed the same cholesterol enriched atherogenic diet. This hypercholesterolemia is associated with an altered distribution of apoE among lipoprotein particles...
  28. MINORITY SCHOOL FACULTY DEVELOPMENT AWARD
    SEKHARA BASAVARAJU; Fiscal Year: 1991
    ..Two groups of pigeons will also be fed nifedipine along with the atherogenic diet. Blood pressure, body weight, plasma cholesterol, blood calcium and plasma lipoprotein concentrations will be ..
  29. LIPOPROTEIN METABOLISM GENETIC CONTROL--MOUSE MODEL
    Aldons Lusis; Fiscal Year: 1999
    ..that increased apoAII expression resulted in increased aortic fatty streak lesions in mice-maintained on an atherogenic diet. These conclusions were tested by constructing transgenic mice overexpressing apoAII, and the results were ..
  30. VITAMIN C AND GSH: ROLES IN VASCULAR FUNCTION
    Joseph Vita; Fiscal Year: 2004
    ..culture experiments in projects 1-3 will be expanded to the in vivo level, using experimental animals fed an atherogenic diet and vitamin C and/or GSH modulating agents...
  31. Human Heme Oxygenase-1 Gene Regulation by Oxidized LDL
    Anupam Agarwal; Fiscal Year: 2006
    ..Aim IA will evaluate the effects of an atherogenic diet in HO-l deficient mice in vivo...
  32. G6PD MARKER FOR MONOTYPISM IN BABOON ATHEROSCLEROSIS
    JOHN VANDEBERG; Fiscal Year: 1992
    ..Forty heterozygous baboons will be made moderately hyperlipidemic by an atherogenic diet, and 20 of these also will be made hypertensive by renal artery stenosis. After 2...
  33. EXERCISE, STRESS AND BLOOD PRESSURE REGULATION
    Robert Shade; Fiscal Year: 1993
    ..model of social stress; (3) graded work on a treadmill as a model of exercise; (4) baboons who will be fed an atherogenic diet; and (5) an instrumented tether system that allows us to obtain measurement of cardiovascular and biochemical ..
  34. ARTERIAL MORPHOLOGY AND REMODELING IN ATHEROSCLEROSIS
    Richard Kerber; Fiscal Year: 1993
    ..Experimental animals will be fed an atherogenic diet; atherosclerotic arterial remodeling will be studied...
  35. SOCIAL STATUS AND ATHEROSCLEROSIS IN FEMALES
    CAROL SHIVELY; Fiscal Year: 1991
    ..The proposed experiment requires 48 adult female cynomolgus macaques (Macaca fascicularis), fed an atherogenic diet and living in social groups of four animals each...
  36. Environmental Stress and the Vascular Cell Transcriptome
    Charles Johnson; Fiscal Year: 2003
    ..Mice feed an atherogenic diet will be challenged with benzo(a)pyrene to modulate overlapping signal transduction cascades leading to ..
  37. Mineralization studies related to atherosclerosis
    HOWARD HSU; Fiscal Year: 2004
    ..abstract_text> ..
  38. Role of Acetaldehyde in Alcoholic Cardiomyopathy
    Jun Ren; Fiscal Year: 2008
    ..Our long-term goal is to establish the toxic mechanism of acetaldehyde in the development of alcoholic cardiomyopathy so that prevention and treatment can be optimized [unreadable] [unreadable]..
  39. IGF-1, Oxidative Stress and Cardiovascular Aging
    Jun Ren; Fiscal Year: 2002
    ..Our long-term goal is to establish the causal link among IGF-1 deficiency, enhanced oxidative damage and ventricular dysfunction in the progression of cardiovascular aging so that hormonal or antioxidant therapy can be optimized...
  40. GENETIC MECHANISMS OF ESTROGEN ATHEROPROTECTION
    Amparo Villablanca; Fiscal Year: 2003
    ..Advances in our basic understanding of mechanisms of hormone action could lead to more effective strategies for treatment of coronary artery disease in both men and women. ..
  41. Regulation of atherosclerosis susceptibility.
    Weibin Shi; Fiscal Year: 2006
    ..In Specific Aim 4, we will conduct molecular analysis to characterize the causative genes residing in the chromosomal regions that influence atherosclerotic lesion formation. [unreadable] [unreadable]..
  42. CARDIOVASCULAR NUTRITION IN MEDICAL EDUCATION
    Scott Grundy; Fiscal Year: 2002
    ..The long term goal is to produce graduates who routinely address nutrition and exercise for cardiovascular health with their patients. ..
  43. PROGESTOGENS VS PHYTOESTROGENS-- AN ADJUNCT TO ERT
    James Williams; Fiscal Year: 2004
    ....
  44. Atherosclerosis Stage, Estrogen Receptors, and Vascular Responses to Estrogen
    THOMAS COSTIN REGISTER; Fiscal Year: 2010
    ....
  45. ENDOTHELIAL PROGENITOR CELLS FOR ENGINEERING VESSELS
    James Williams; Fiscal Year: 2008
    ..As such, these studies are an exciting and unique direction of research for Dr. Williams in collaboration with his colleagues at WFIRM. [unreadable] [unreadable] [unreadable]..
  46. QTL analysis of carotid atherosclerosis
    Weibin Shi; Fiscal Year: 2007
    ..One to two major QTLs for atherosclerotic lesions will be dissected through construction of congenic strains. ..
  47. Genetic analysis of neointimal hyperplasia
    Weibin Shi; Fiscal Year: 2009
    ..One to two major QTLs for neointimal hyperplasia will be dissected through construction and analysis of congenic strains. ..
  48. Chromium and Insulin Action
    William Cefalu; Fiscal Year: 2006
    ..abstract_text> ..
  49. Role of the CD40/CD40L dyad in atherosclerosis
    Masanori Aikawa; Fiscal Year: 2006
    ..abstract_text> ..
  50. HORMONE REPLACEMENT FOR PREVENTION OF VISCERAL OBESITY
    William Cefalu; Fiscal Year: 2002
    ....
  51. Upgrade of mass spectrometer facility
    Michael Thomas; Fiscal Year: 2003
    ..The new mass spectrometer will provide 1) a significant increase in detection sensitivity, 2) higher resolution, 3) greater accuracy of mass measurement, 4) increased reliability, and 5) compatibility with new generations of software. ..
  52. REGULATION OF PTH-INDUCED BONE ANABOLISM BY INFLAMMATORY LIPIDS
    Yin Tintut; Fiscal Year: 2007
    ..The proposed studies will determine how high cholesterol reduces efficacy of parathyroid hormone so that corrective strategies can be developed. [unreadable] [unreadable] [unreadable]..
  53. Gene expression networks for metabolic syndrome traits in mice
    Thomas A Drake; Fiscal Year: 2010
    ....
  54. New Mechanisms in the Pathogenesis of Diabetic Nephropathy
    Rama Natarajan; Fiscal Year: 2008
    ..They could also pave the way for novel new therapies for various complications of diabetes including nephropathy. [unreadable] [unreadable] [unreadable]..
  55. Muscle PPARgamma and Metabolic Regulation
    Andrew Norris; Fiscal Year: 2008
    ..abstract_text> ..
  56. SOY, LIFE STAGE, STRESS AND ATHEROSCLEROSIS IN FEMALES
    JAY KAPLAN; Fiscal Year: 2009
    ..of an ongoing study that currently contains sociallyhoused, premenopausal monkeys consuming a moderately atherogenic diet, in which protein is derived from either SOY or casein-lactalbumin (C/L)...
  57. Coronary Reactivity and Thromboxane Receptor Expression
    R Hermsmeyer; Fiscal Year: 2005
    ....
  58. Proatherogenic properties of platelet fator 4
    Bruce S Sachais; Fiscal Year: 2010
    ..into the role of PF4, the most abundant protein released by activated platelets, on the development of atherosclerosis, delineate the pathways by which this occurs in vivo, and suggest potential methods to intervene in atherogenesis ..
  59. ER beta selective agonist coronary protection-menopause
    R Hermsmeyer; Fiscal Year: 2005
    ..The new ERbetaA is to be contrasted with PremPro(r) (oral conjugated equine estrogens plus medroxyprogesterone acetate) which failed to provide cardiovascular protection in the Women's Health Initiative. ..
  60. Effects of Statins on AD beyond Cholesterol and Amyloid
    Ling Li; Fiscal Year: 2006
    ..abstract_text> ..