Genomes and Genes
containment of biohazards
Summary: Provision of physical and biological barriers to the dissemination of potentially hazardous biologically active agents (bacteria, viruses, recombinant DNA, etc.). Physical containment involves the use of special equipment, facilities, and procedures to prevent the escape of the agent. Biological containment includes use of immune personnel and the selection of agents and hosts that will minimize the risk should the agent escape the containment facility.
Publications240 found, 100 shown here
- ARAMIS project: a more explicit demonstration of risk control through the use of bow-tie diagrams and the evaluation of safety barrier performanceValérie de Dianous
INERIS, Direction des Risques Accidentels, Parc Technologique ALATA, BP2 60 550 Verneuil en Halatte, France
J Hazard Mater 130:220-33. 2006..During the risk analysis, a practical tool called risk graph is used to assess if the number and the reliability of the safety functions for a given cause are sufficient to reach a good risk control...
- The impact of regulations, safety considerations and physical limitations on research progress at maximum biocontainmentAmy C Shurtleff
Integrated Toxicology Division, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702, USA
Viruses 4:3932-51. 2012..The possibilities and limitations of biomedical research involving microbial pathogens of biodefense concern in BSL-4 containment laboratories are explored in this review...
- Biosafety breaches. Accidents spur a closer look at risks at biodefense labsJocelyn Kaiser
Science 317:1852-4. 2007
- Clinical laboratories, the select agent program, and biological surety (biosurety)Ross H Pastel
United States Army Medical Research Institute of Infectious Diseases USAMRIID, 1425 Porter Street, Fort Detrick, MD 21702, USA
Clin Lab Med 26:299-312, vii. 2006..Both sets of regulations have four pillars (safety, physical security, agent account-ability, and personnel reliability) that are built on a foundation of training and covered by a roof of management (operations and plans)...
- A computerized data-capture system for animal biosafety level 4 laboratoriesDennis A Bente
Special Pathogens Program, Public Health Agency of Canada, University of Manitoba, Winnipeg, MB, Canada
J Am Assoc Lab Anim Sci 50:660-4. 2011....
- Public health and biosecurity. Life sciences at a crossroads: respiratory transmissible H5N1Michael T Osterholm
Center for Infectious Disease Research and Division of Environmental Health Sciences, Medical School, University of Minnesota, Minneapolis, MN 55455, USA
Science 335:801-2. 2012
- Framework for leadership and training of Biosafety Level 4 laboratory workersJames W Le Duc
Institute for Human Infections and Immunity, Galveston National Laboratory, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 0610, USA
Emerg Infect Dis 14:1685-8. 2008..Although standardized certification of training does not formally exist, the directors agreed that facility-specific, time-limited documentation to recognize specific skills and experiences of trained persons is needed...
- Managing potential laboratory exposure to ebola virus by using a patient biocontainment care unitMark G Kortepeter
US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA
Emerg Infect Dis 14:881-7. 2008..Research facilities contemplating work with pathogens requiring Biosafety Level 4 laboratory precautions should be mindful of the occupational health issues highlighted in this article...
- Public health and biosecurity. H5N1 debates: hung up on the wrong questionsDaniel R Perez
Department of Veterinary Medicine, University of Maryland, College Park, MD 20742 3711, USA
Science 335:799-801. 2012
- [Current biosafety in clinical laboratories in Japan: report of questionnaires' data obtained from clinical laboratory personnel in Japan]Mieko Goto
Division of Infectious Diseases, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo
Kansenshogaku Zasshi 81:39-44. 2007..These results suggest that biosafety systems are woefully lacking or inadequate in clinical laboratories in Japan and must be established at the earliest possible opportunity...
- High-containment biodefense research laboratories: meeting report and center recommendationsGigi Kwik Gronvall
The Center for Biosecurity of The University of Pittsburgh Medical Center, Baltimore, Maryland 21202, USA
Biosecur Bioterror 5:75-85. 2007
- Research in the hot zoneRobert Steinbrook
N Engl J Med 354:109-12. 2006
- Biodefense labs. Boston University Under Fire for Pathogen MishapAndrew Lawler
Science 307:501. 2005
- Patient care in a biological safety level-4 (BSL-4) environmentLeRoy A Marklund
Operational Medicine Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA
Crit Care Nurs Clin North Am 15:245-55. 2003....
- Air evacuation under high-level biosafety containment: the aeromedical isolation teamG W Christopher
U S Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702 5011
Emerg Infect Dis 5:241-6. 1999..This article also examines technical aspects of the team's equipment, training, capabilities, and deployments...
- Biosafety considerations for autopsyKurt B Nolte
University of New Mexico School of Medicine, Albuquerque, New Mexico
Am J Forensic Med Pathol 23:107-22. 2002..These risks can be substantially mitigated through proper assessment, personal protective equipment, appropriate autopsy procedures, and facility design...
- Yersinia pestis: still a plague in the 21st centuryDeborah Josko
School of Health Related Professions, Department of Clinical Laboratory Science, University of Medicine and Dentistry of New Jersey, Newark, NJ 07107, USA
Clin Lab Sci 17:25-9. 2004..Unless antibiotics are administered within 24 hours of the initial symptoms, death is inevitable. Its potential for use as a biological weapon is of major concern to public health officials...
- Botulin toxin: a weapon in terrorismDeborah Josko
School of Health Related Professions, Department of Clinical Laboratory Science, University of Medicine and Dentistry of New Jersey, Newark, NJ 07107, USA
Clin Lab Sci 17:30-4. 2004..Due to the severity and potency of this neurotoxin, its importance as a biological weapon is of major concern to public health officials...
- Francisella tularensis: possible agent in bioterrorismMelissa Gallagher-Smith
University of Medicine and Dentistry of New Jersey School of Health Related Professions, Newark, NJ 07107, USA
Clin Lab Sci 17:35-9. 2004..Therefore, it is very important for both medical professionals and public health officials to be prepared to contain and control the situation should it actually occur...
- Viable infectious cell sorting in a BSL-3 facilityStephen P Perfetto
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Methods Mol Biol 263:419-24. 2004..With this system in place, aerosol containment can be measured quickly and efficiently, therefore reducing the risk to the operator when sorting viable infectious cells...
- Evidence-based biosafety: a review of the principles and effectiveness of microbiological containment measuresTjeerd G Kimman
Center for Infectious Disease Control, RIVM National Institute of Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands
Clin Microbiol Rev 21:403-25. 2008..It is unknown to what extent specific measures contribute to the overall level of biosafety. We therefore recommend that the evidence base of biosafety practice be strengthened...
- Biosafety concerns for shared flow cytometry core facilitiesIngrid Schmid
David Geffen School of Medicine at UCLA, Department of Hematology Oncology, Los Angeles, California 90095, USA
Cytometry A 56:113-9. 2003..In this report we review safety issues that are pertinent to flow cytometry core facilities by discussing the individual components of this biosafety questionnaire...
- Regulation of biological research in the terrorism eraBarry Kellman
International Weapons Control Center, DePaul University College of Law, USA
Health Matrix Clevel 13:159-80. 2003
- Biodefense facilities. Suit targets two DOE labsDavid Malakoff
Science 301:1168-9. 2003
- Setting biohazard guidelines in a facility: a Catch 22Diane J Gaertner
Contemp Top Lab Anim Sci 42:8. 2003
- Defining and managing biohazardous waste in U.S. research-oriented universities: a survey of environmental health and safety professionalsRobin Lyn Mecklem
Department of Public Health, Oregon State University, Corvallis, OR 97331 6406, USA
J Environ Health 66:17-22. 2003..To ensure compliance with institutional policy, most universities segregate and package waste, train waste generators, and conduct inspections...
- Complying with the Occupational Safety and Health Administration's Bloodborne Pathogens Standard: implementing needleless systems and intravenous safety devicesMichelle A Marini
Emergency Services, Children s Hospital, Boston, MA 02115, USA
Pediatr Emerg Care 20:209-14. 2004..Addressing these obstacles and providing adequate training for all clinicians were required for successful implementation of these i.v. safety devices...
- Biosafety: guidelines for working with pathogenic and infectious microorganismsRichard Coico
Weill Medical College of Cornell University, New York, New York, USA
Curr Protoc Immunol . 2005..In addition, resources for more information are provided in the Literature Cited and Key References sections and in URLs given text and within the Internet Resources section...
- [Accidents with biological material at West Paraná University Hospital]Neide Tiemi Murofuse
REPAT USP, Rede de Prevenção de Acidentes de Trabalhos com Material Biológico em Hospitais Brasileiros
Rev Gaucha Enferm 26:168-79. 2005..Out of the 586 hospital workers, there was a register of 20 (3,4%) injured workers in 2003 and 23 (3,8%) in 2004, representing an increase of 15% in the notifications from one year to the other...
- Land use planning in IndiaJ P Gupta
Department of Chemical Engineering, Indian Institute of Technology, Kanpur 208026, India
J Hazard Mater 130:300-6. 2006..level of industrialization in different parts, need for creation of jobs, eco-sensitive regions, tribal regions, historical monuments, etc. This paper discusses the current scene in India and the near future aspects...
- The development of an audit technique to assess the quality of safety barrier managementFrank Guldenmund
Safety Science Group, Delft University of Technology, Netherlands
J Hazard Mater 130:234-41. 2006..However, this strength is also its limitation, since the full safety management system is not covered with the technique. Finally, some preliminary experiences obtained from several test sites are compiled and discussed...
- ARAMIS project: a comprehensive methodology for the identification of reference accident scenarios in process industriesChristian Delvosalle
Faculte Polytechnique de Mons, Major Risk Research Centre, 56 rue de l Epargne, 7000 Mons, Belgium
J Hazard Mater 130:200-19. 2006..The reference accident scenarios are chosen with the help of a tool called "risk matrix", crossing the frequency and the consequences of accidents. This paper presents both methodologies and an application on an ethylene oxide storage...
- Environmental vulnerability assessment in the vicinity of an industrial site in the frame of ARAMIS European projectJ Tixier
Industrial Risk and Natural Hazard Department, LGEI, Ecole des Mines d Alès, 6 avenue de Clavières, 30319 Ales Cedex, France
J Hazard Mater 130:251-64. 2006..The result is an operational tool allowing competent authorities, industrialists and risk experts to assess the vulnerability of the area surrounding an industrial site...
- The accidental risk assessment methodology for industries (ARAMIS)/layer of protection analysis (LOPA) methodology: a step forward towards convergent practices in risk assessment?Richard Gowland
European Process Safety Centre, 161 189 Railway Terrace, Rugby, Warwickshire CV 21 3 HQ, UK
J Hazard Mater 130:307-10. 2006..LOPA is potentially a means of carrying out the assessment of barriers required in ARAMIS. This paper attempts to explain the principles of LOPA and the means by which it can be used within ARAMIS...
- [Occupational risk for blood exposure and staff behaviour: a cross-sectional study in 3 Moroccan healthcare centers]K Djeriri
Service Santé Travail Environnement, CHU de Clermont Ferrand, Place Henri Dunant, 63000 Clermont Ferrand, France
Med Mal Infect 35:396-401. 2005..The study included health-care workers in the Taza and Temara hospitals and health centers, as well as in a Rabat public medical analysis laboratory...
- A risk severity index for industrial plants and sitesE Planas
Centre d Estudis del Risc Tecnològic, Universitat Politecnica de Catalunya, Diagonal 647, 08028 Barcelona, Catalonia, Spain
J Hazard Mater 130:242-50. 2006..The methodology has been applied to diverse test cases and it has proved to be useful for risk assessment, for comparative studies and for land use planning...
- Quantifying the influence of safety management on the reliability of safety barriersNijs Jan Duijm
Risø National Laboratory, Systems Analysis Department, P O Box 49, DK 4000 Roskilde, Denmark
J Hazard Mater 130:284-92. 2006..A preliminary set of weight factors is presented with some examples of resulting reductions in reliability--this demonstration confirms that the set of weight factors needs further development...
- Improving the biosafety of cell sorting by adaptation of a cell sorting system to a biosafety cabinetKlaus Lennartz
Institute of Cell Biology Cancer Research, West German Cancer Center Essen, University of Duisburg Essen, Medical School, Essen, Germany
Cytometry A 66:119-27. 2005..With aid of this unit, sorting can be performed in conformance with the recommendations for biosafety level 2...
- Facility design considerations for select agent animal researchDan Frasier
Commissioning Services, Cornerstone Commissioning, Inc, Boxford, Massachusetts, USA
ILAR J 46:23-33. 2005....
- Biosafety practices associated with potential agents of biocrime and biowarfareLouAnn C Burnett
Vanderbilt University, Nashville, Tennessee, USA
Curr Protoc Microbiol . 2006..Procedures describing physical security, personnel reliability, and material control and accountability define a security plan for this type of research...
- Standard safety practices for sorting of unfixed cellsIngrid Schmid
David Geffen School of Medicine at UCLA, Los Angeles, California, USA
Curr Protoc Cytom . 2007....
- Biosafety lab passes disaster testRex Dalton
Nature 455:1012. 2008
- A primer on the requirements for select agents and toxins used in biomedical and agricultural research applicationsT P Johnston
New York Medical College, Vosburgh 237, Valhalla, NY 10595, USA
Health Phys 90:S56-61. 2006..This summary is necessary since radiolabeled select agents and toxins are being utilized in research applications and require oversight by the health physicist...
- National Science Advisory Board for Biosecurity reviews papers, holds second meetingJackie Fox
Biosecur Bioterror 4:9-11. 2006
- No use crying over spilled PERCJoe Lorenz
PRO TERRA Environmental Contracting Co, Columbus, Ohio, USA
Occup Health Saf 73:48, 50, 52. 2004
- Select agent regulationsJanet C Gonder
Garber Consulting LLC, Pinehurst, NC, USA
ILAR J 46:4-7. 2005..A brief overview of recent regulations is presented, as well as where to obtain additional information on regulations, standards, and guidelines related to work with select agents and toxins...
- Administrative issues related to infectious disease research in the age of bioterrorismJerry Jaax
Research Compliance, Kansas State University, Manhattan, Kansas, USA
ILAR J 46:8-14. 2005....
- Issues related to the use of animals in biocontainment research facilitiesJohn Copps
Canadian Food Inspection Agency, National Centre for Animal Care, Winnipeg, Manitoba, Canada
ILAR J 46:34-43. 2005..The challenges of working with infectious disease agents in high levels of containment, and some solutions to these challenges, are described from an animal care point of view...
- Congress queries need for and safety of high-containment research laboratoriesMike Mitka
JAMA 298:2359-60. 2007
- Interview with Jean L. Patterson, PhD, Chairman, Department of Virology and Immunology, Southwest Foundation for Biomedical ResearchMadeline Drexler
Biosecur Bioterror 5:97-103. 2007
- Keeping cool in the hot zoneMarc Barrera
Occup Health Saf 77:90. 2008
- New EU regulations: towards biosecurity but not censorshipCarsten Roller
Eur J Immunol 37:3301-3. 2007
- [Biosafety in laboratories concerning exposure to biological agents]N Vonesch
Istituto Superiore per la Prevenzione e la Sicurezza del Lavoro, Dipartimento Medicina del Lavoro
G Ital Med Lav Ergon 28:444-56. 2006..This paper describes some aspects that include good microbiological practices (GMPs), appropriate containment equipment, practices and operational procedures to minimize workers' risk of injury or illness...
- Biodefense. Lawmakers worry that lab expansion poses risksJocelyn Kaiser
Science 318:182. 2007
- The changing world of biocontainment and biosecurityM Jeggo
OIE Collaborating Centre for New and Emerging Diseases, Australian Animal Health Laboratory, Australia
Dev Biol (Basel) 128:47-51. 2007..The Australian Animal Health Laboratory (AAHL) provides an example of what might be considered best practice in biocontainment while considering regulations, cost and need...
- Specimen collection, storage, and transmission to the laboratory for hematological testsN Tatsumi
Department of Clinical and Laboratory Medicine, Osaka City University Medical School, Osaka, Japan
Int J Hematol 75:261-8. 2002
- Managing a low-level mixed waste storage facility: a checklist for compliance to 40 CFR 266Kenyon D Yoder
Principle HES, Corporate Safety and I H, Bayer Corporation, Pittsburgh, PA 15205, USA
Health Phys 82:S77-81. 2002....
- Hazardous materials responses in a mid-sized metropolitan areaFrank G Walter
Arizona Emergency Medicine Research Center, Division of Medical Toxicology, Medical Toxicology Fellowship, Department of Emergency Medicine, College of Medicine, University of Arizona, Tucson, Arizona 85724 5057, USA
Prehosp Emerg Care 7:214-8. 2003..To determine the chemicals involved in fire department hazardous materials (hazmat) responses and analyze the concomitant emergency medical services' patient care needs...
- International Society for Analytical Cytology biosafety standard for sorting of unfixed cellsIngrid Schmid
Department of Hematology Oncology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
Cytometry A 71:414-37. 2007..However, the field of cytometry has progressed since 1997, and the document requires an update...
- Differences in the cost of antidepressants across state Medicaid programsChristina M L Kelton
College of Business, University of Cincinnati, PO Box 210223, Cincinnati, OH 45221 0223, USA
J Ment Health Policy Econ 11:33-47. 2008....
- Review of occupational medicine practice guidelines for interventional pain management and potential implicationsLaxmaiah Manchikanti
Pain Management Center of Paducah, Paducah, KY 42003, USA
Pain Physician 11:271-89. 2008....
- Effect of precipitation, sorption and stable of isotope on maximum release rates of radionuclides from engineered barrier system (EBS) in deep repositoryA Malekifarsani
Moscow Power Engineering Institute Technical University, Krasnokazarmennaya st, 17T Aviamatorhaya, Moscow, Russian Federation
J Environ Radioact 100:807-14. 2009..For example, release rates of Pu-240, Cm-246 and Am-241, which are relatively short-lived and strongly sorbing, are very small, whereas that of Zr-93, which is also strongly sorbing but long-lived, is significantly higher...
- Low pH gel intranasal sprays inactivate influenza viruses in vitro and protect ferrets against influenza infectionPaul Rennie
Procter and Gamble Health Sciences Institute, Egham, Surrey, UK
Respir Res 8:38. 2007..The work described here investigated the sensitivity of influenza viruses to low pH, and the activity of low pH nasal sprays on the course of an influenza infection in the ferret model...
- The complete chloroplast genome sequence of Citrus sinensis (L.) Osbeck var 'Ridge Pineapple': organization and phylogenetic relationships to other angiospermsMichael G Bausher
USDA ARS, Horticultural Research Laboratory, Fort Pierce, FL 34945 3030, USA
BMC Plant Biol 6:21. 2006..We have sequenced the Citrus chloroplast genome to facilitate genetic improvement of this crop and to assess phylogenetic relationships among major lineages of angiosperms...
- Evaluation of a novel chromogenic agar medium for isolation and differentiation of vancomycin-resistant Enterococcus faecium and Enterococcus faecalis isolatesNathan A Ledeboer
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
J Clin Microbiol 45:1556-60. 2007..faecalis and E. faecium. Extending the incubation period beyond 24 h did not significantly improve the recovery of VRE and resulted in decreased specificity...
- Gated stress-only 99mTc myocardial perfusion SPECT imaging accurately assesses coronary artery diseaseC A Santana
Radiology Department, Emory University Hospital, Atlanta, Georgia 30322, USA
Nucl Med Commun 24:241-9. 2003....
- Mutilation of self and object: the destructive world of the paranoid-schizoid patient and the struggle for containment and integrationRobert T Waska
Psychoanal Rev 89:373-98. 2002..In this final stage, the patient "O" was able to acknowledge, work through, and integrate her prior feelings and phantasies of loss, persecution, and abandonment anxiety into more manageable and reality-based depressive functioning...
- Cost-effective approach of video-assisted thoracic surgery: 7 years experienceH P Liu
Department of Anesthesiology, Chang Gung Memorial Hospital, Taipei, Taiwan
Chang Gung Med J 23:405-12. 2000..Only through stringent use of expensive endoscopic consumables and application of modified techniques based on traditional surgical principles can VATS be performed efficaciously and economically for a wide range of thoracic conditions...
- Hospital utilization, efficiency and access to care during and shortly after restructuring acute care in Newfoundland and LabradorBrendan Barrett
Clinical Epidemiology Unit, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland and Labrador, Canada
J Health Serv Res Policy 10:S2:31-7. 2005....
- The impact of China's retail drug price control policy on hospital expenditures: a case study in two Shandong hospitalsQingyue Meng
Center for Health Management and Policy, Shandong University, Wenhua Xi Rd 44, Jinan, Shandong 250012, China
Health Policy Plan 20:185-96. 2005..Improvement of rational use of drugs and correcting the present incentive structure for hospitals and drug prescribers may be important additional strategies for achieving containment of drug expenditures...
- Autograft containment in posterolateral spine fusionRaj D Rao
Department of Orthopaedic Surgery, Medical College of Wisconsin, 9200 W Wisconsin Avenue, Milwaukee, WI 53226 0099, USA
Spine J 8:563-9. 2008..Biocontainment devices have been clinically used in the skull and mandible to guide bone regeneration. The role of a mechanical device in containing graft material in the developing posterolateral lumbar spine fusion is unclear...
- Commercialization of a novel fermentation conceptKiran Mazumdar-Shaw
Biocon India Limited, 20th KM, Hosur Road, Hebbagodi 561229, Bangalore, India
Adv Biochem Eng Biotechnol 85:29-42. 2003....
- Blood profile holds clues to role of infection in a premonitory state for idiopathic parkinsonism and of gastrointestinal infection in established diseaseAndre Charlett
Therapeutics Research Group, Institute of Psychiatry at King s College London, London, UK
Gut Pathog 1:20. 2009..Thus, two prognostic indicators in established IP fit with involvement of Helicobacter and SIBO...
- The nine-year sustained cost-containment impact of swiss pilot physicians-pharmacists quality circlesAnne Niquille
Universities of Geneva and Lausanne, Switzerland
Ann Pharmacother 44:650-7. 2010..PPQCs are based on a multifaceted collaborative process mediated by community pharmacists for improving compliance with clinical guidelines within GPs' prescribing practices...
- The biomechanical influence of tibio-talar containment on stability of the ankle jointArno Frigg
Department of Orthopaedic Surgery, University of Basel, Basel, Switzerland
Knee Surg Sports Traumatol Arthrosc 15:1355-62. 2007..People who have an unstable ankle configuration and who nevertheless engage in activities with high risk of ankle sprains could be asked to wear ankle protecting sports equipment...
- New concepts and technologies in home care and ambulatory monitoringA Dittmar
Microcapteurs et Microsystèmes Biomédicaux, INSA Lyon, bat Leonard de Vinci, CNRS LPM, 20 Avenue Albert Einstein, 69621 Villeurbanne Cedex, France
Stud Health Technol Inform 108:9-35. 2004..A "societal health education" has to be provided to physicians and to patients to get all the benefits of this new context...
- Effects of a step-therapy program for angiotensin receptor blockers on antihypertensive medication utilization patterns and cost of drug therapyKrista Yokoyama
WellPoint NextRx, West Hills, CA 91304, USA
J Manag Care Pharm 13:235-44. 2007..Step therapy for angiotensin receptor blockers (ARBs) requiring prior use of angiotensin-converting enzyme inhibitors (ACEIs) is a common cost-containment intervention in managed care...
- Inactivated influenza vaccines: recent progress and implications for the elderlyValentina Parodi
Department of Health Sciences, University of Genoa, Italy
Drugs Aging 28:93-106. 2011....
- Supporting future surgical innovation. Lung transplantation as a case studyK Reemtsma
Habif Center for Surgical Studies, Columbia University, College of Physicians and Surgeons, New York, NY
Ann Surg 218:465-73; discussion 474-5. 1993..It was concluded that provisional coverage within a predetermined research protocol may be a promising mechanism to remedy this situation, providing timely assessment of new procedures before widespread application...
- Poultry litter application to loblolly pine forests: growth and nutrient containmentAlexander L Friend
USDA Forest Service, North Central Research Station, 410 MacInnes Drive, Houghton, MI 49931, USA
J Environ Qual 35:837-48. 2006....
- Reversed remodelling in dilated cardiomyopathy by passive containment surgery is associated with decreased circulating levels of endothelin-1Fredrik Bredin
Department of Cardiothoracic Surgery and Anesthesiology, Karolinska University Hospital, S 171 76 Stockholm, Sweden
Eur J Cardiothorac Surg 29:299-303. 2006..To evaluate the influence on circulating levels of endothelin-1 and big endothelin-1 in relation to echocardiographic findings and functional assessment, by passive containment surgery in heart failure patients with dilated cardiomyopathy...
- Pursuing cost containment in a pluralistic payer environment: from the aftermath of Clinton's failure at health care reform to the Balanced Budget Act of 1997Rick Mayes
Department of Political Science, University of Richmond and Petris Centre on Health Care Markets and Consumer Welfare, University of California, Berkeley, CA, USA
Health Econ Policy Law 1:237-61. 2006....
- Breast cancer survival and treatment in health maintenance organization and fee-for-service settingsA L Potosky
Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD 20892 7344, USA
J Natl Cancer Inst 89:1683-91. 1997....
- Has cost containment after the National Health Insurance system been successful? Determinants of Taiwan hospital costsJung Hua Hung
Department of Business Administration, National Central University, Jhongli, Taiwan
Health Policy 85:321-35. 2008..Finally, policymakers should establish related benchmark indices for what drivers up hospital costs (micro-aspect) and to control healthcare expenditures (macro-level)...
- Detecting continuity violations in infancy: a new account and new evidence from covering and tube eventsSu Hua Wang
Department of Psychology, University of California, 1156 High Street, Santa Cruz, CA 95064, USA
Cognition 95:129-73. 2005..A new account of infants' physical reasoning attempts to make sense of all of these results. New research directions suggested by the account are also discussed...
- Sequence diversity of the Trypanosoma cruzi complement regulatory protein familyM Beucher
Department of Immunology E1004, University of Pittsburgh School of Medicine, Pittsburgh, PA 15237, USA
Infect Immun 76:750-8. 2008..Finally, we show that a clonal line of T. cruzi expresses multiple unique copies of CRP that are differentially recognized by patient sera...
- Local control of the immune response in the liverP A Knolle
Zentrum für Molekulare Biologie Heidelberg, University of Heidelberg, Germany
Immunol Rev 174:21-34. 2000..Besides sinusoidal endothelial cells, other cell populations of the liver, such as dendritic cells, Kupffer cells and perhaps also hepatocytes, may contribute to tolerance induction by deletion of T cells through induction of apoptosis...
- Changes in natriuretic peptides following passive containment surgery in heart failure patients with dilated cardiomyopathyFredrik Bredin
Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
Interact Cardiovasc Thorac Surg 8:191-4. 2009..56+/-3 mm, P<0.01). Following passive containment surgery using the ACORN Cardiac Support Device functional improvement and reversed remodelling is accompanied by decreased BNP levels...
- Switching to gatekeeping: changes in expenditures and utilization for childrenT G Ferris
Institute for Health Policy, Division of General Medicine, Massachusetts General Hospital for Children and Harvard Medical School, Boston, Massachusetts 02114, USA
Pediatrics 108:283-90. 2001..Little empirical research describes the impact of switching into a gatekeeping plan on health care expenditures and utilization for children...
- Cameroon: an African model for final stages of guinea worm eradicationG Greer
Vector Biology and Control Project, Arlington, Virginia
Am J Trop Med Hyg 50:393-400. 1994..Weekly reporting should be extended to all villages with recent confirmed cases and to as many villages reporting cases during the previous transmission season as logistically possible.(ABSTRACT TRUNCATED AT 250 WORDS)..
- Honeybee flight metabolic rate: does it depend upon air temperature?William A Woods
Department of Biology, University of Massachusetts Boston, Massachusetts 02125 3393, USA
J Exp Biol 208:1161-73. 2005....
- Arsenic removal using steel manufacturing byproducts as permeable reactive materials in mine tailing containment systemsJoo Sung Ahn
Department of Earth System Sciences, Yonsei University, Seoul 120 749, South Korea
Water Res 37:2478-88. 2003..When applied to real tailing leachate, ECD was found to be the most efficient barrier material to increase pH and to remove As and dissolved metals...
- Rural-urban differences in health care benefits of a community-based sample of at-risk drinkersJohn C Fortney
VA HSR and D Center for Healthcare and Outcomes Research, Central Arkansas Veterans Healthcare System, USA
J Rural Health 19:292-8. 2003..Different types of health plan cost-containment strategies (eg, gatekeeping, selective contracting, and cost-sharing) may affect the utilization of behavioral health services differently in urban and rural areas...
- Effects of time of administration and dietary iodine levels on potassium iodide (KI) blockade of thyroid irradiation by 131I from radioactive falloutP B Zanzonico
Nuclear Medicine Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Health Phys 78:660-7. 2000....
- Natural rates of sediment containment of PAH, PCB and metal inventories in Sydney Harbour, Nova ScotiaJ N Smith
Bedford Institute of Oceanography, Fisheries and Oceans Canada, Dartmouth, NS, Canada B2Y 4A2
Sci Total Environ 407:4858-69. 2009....
- The complete chloroplast genome sequence of Gossypium hirsutum: organization and phylogenetic relationships to other angiospermsSeung Bum Lee
Dept of Molecular Biology and Microbiology, University of Central Florida, Biomolecular Science, Building 20, Orlando, FL 32816 2364, USA
BMC Genomics 7:61. 2006..In addition, the sequence data were used to assess phylogenetic relationships among the major clades of rosids using cotton and 25 other completely sequenced angiosperm chloroplast genomes...
- Potential use of densified polymer-pastefill mixture as waste containment barrier materialsM Fall
Department of Civil Engineering, University of Ottawa, Ontario, Canada
Waste Manag 30:2570-8. 2010..10, 0.20 and 0.5% of SAP. From this study, it can be concluded that PP materials show encouraging performance properties for barrier design...
- [Frequency of decubitus ulcer in patients of a university medical center. Combination of routine documentation and cross-sectional study]J Stausberg
Institut für Medizinische Informatik, Biometrie und Epidemiologie, Universitatsklinikum Essen, Hufelandstrasse 55, 45122 Essen
Dtsch Med Wochenschr 130:2311-5. 2005..The interdisciplinary pressure ulcer project at the University Clinics in Essen combined a routine documentation with a cross-sectional survey, thus providing both measurements for the first time...
- Influenza A (H1N1-2009) pandemic in Singapore--public health control measures implemented and lessons learntJoanne Tay
Communicable Diseases Division, Ministry of Health, Singapore
Ann Acad Med Singapore 39:313-12. 2010..Documenting the measures taken and lessons learnt provides a learning opportunity for both doctors and policy makers, and can help fortify Singapore's ability to respond to future major disease outbreaks...
- Laboratory containment of SARS virusWilina Lim
Virology Division, Public Health Labortory Services Branch, Centre for Health Protection, Department of Health, Hong Kong
Ann Acad Med Singapore 35:354-60. 2006..Audits of these laboratories in 2004 showed that laboratory safety and containment requirements as recommended were generally met...
- Prescription duration after drug copay changes in older people: methodological aspectsSebastian Schneeweiss
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Ave, Boston, MA 02115, USA
J Am Geriatr Soc 50:521-5. 2002..Reference pricing, a copayment for expensive medications above a fixed limit, for angiotensin-converting enzyme(ACE) inhibitors in older British Columbia residents, is used as a case example...
- Clinically enhanced multi-purpose administrative dataset for comparative effectivHamisu Salihu; Fiscal Year: 2010....
- Recombinant Attenuated Salmonella Vaccines for HumansRoy Curtiss; Fiscal Year: 2012..We will also develop a RASV using S. Typhi as vector to prevent transmission and infection by Mycobacterium tuberculosis. ..
- Viral and Host Determinants of New World Alphaviral EntryASIM AMINSHARIF AHMED; Fiscal Year: 2013..Children's Hospital Boston is committed to this career development plan and has assured the candidate will be able to devote at least 85% full-time effort to the activities described in this proposal. ..
- Salmonella Vaccines Against Bacterial EnteropathogensRoy Curtiss; Fiscal Year: 2013..If successful, this vaccine(s) should have a societal public health benefit of a magnitude similar to the impact of the smallpox vaccine. ..
- Lactoferrin for Immunomodulation of Systemic Inflammatory Response SyndromeMarian L Kruzel; Fiscal Year: 2011..The goal of this proposal is to examine the utility of a novel human recombinant Lactoferrin to combat SIRS, and limit progression of SIRS. ..
- Expression signatures of TB-specific memory responses within the human lungRichard F Silver; Fiscal Year: 2013..tuberculosis antigens enhance containment of the organism in both Mtb-infected and BCG-vaccinated individuals. ..
- Regional Biocontainment LaboratoryCharles Bailey; Fiscal Year: 2007..The Provost and Chief Financial Officer have committed the University to pay these costs as appropriate should they exceed the balance of the start-up contingency fund. ..
- Molecular Biology of Eukaryotic VirusesBert L Semler; Fiscal Year: 2012....
- IMMUNITY AND VIRUS DISEASERaymond M Welsh; Fiscal Year: 2013..abstract_text> ..
- Integrated MRI-Based Examination for Evaluation of Peripheral Arterial DiseaseFelix W Wehrli; Fiscal Year: 2010....
- Phase I Study to Evaluate Safety and Toxicity of EGCG in HIV-1-Infected SubjectsChristina L Nance; Fiscal Year: 2011..This could result in a significant reduction in the national and global spread of HIV-1 infection with an enormous impact on public health. ..
- The roles of MKP-1 in Gram-negative bacterial sepsis and colitisYusen Liu; Fiscal Year: 2010..These studies will uncover critical immune regulatory mechanisms, and may lead to novel strategies for the treatment of sepsis and inflammatory bowel disease. ..
- Vestibular rehabilitation and dizziness in geriatric patientsCourtney Hall; Fiscal Year: 2012..This project will contribute to improved quality of life and containment of health care costs in the elderly. ..
- A novel Salmonella vaccine to protect against extra intestinal pathogenic E. coliMelha Mellata; Fiscal Year: 2011..Moreover, if successful, the delayed-attenuated lysis system proposed can be used in any live bacterial vaccine to increase their safety and efficacy in delivering antigens. ..
- Pilot studies of the molecular epidemiology of drug-resistant malaria in MyanmarChristopher V Plowe; Fiscal Year: 2013..This work is expected to contribute to the development of robust surveillance tools that can be used to track and contain artemisinin resistance in Southeast Asia and elsewhere. ..
- Novel Screen to Identify Arenavirus InhibitorsJuan Lama; Fiscal Year: 2013..These studies may lead to the development of much needed antivirals for the treatment of highly pathogenic arenavirus infections. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page ..
- Continuous Oxygen Monitor for Patients on Long-Term Oxygen Therapy (COMPLY)B Eugene Parker; Fiscal Year: 2011..The proposed system will provide an elective, practical, and fordable method for reliably assessing LTOT adherence in clinical practice and research settings. ..
- College of Medicine Phoenix Campus Vivarium Phase I ConstructionWilliam M Crist; Fiscal Year: 2010..The best and only way to assure optimal standards of experimental animal care required for our PHS-supported research efforts is to construct this dedicated laboratory animal vivarium serving the Phoenix Biomedical Campus. ..
- Gastric Injury In Trauma and Surgical SepsisDavid I Soybel; Fiscal Year: 2010..Such therapeutic strategies would be applicable not only to injury in the stomach, but to other regions of the GI tract affected by systemic stress and acute inflammation. ..
- Lipid storage and mobilization in M. tuberculosis as antilatency drugs targetsPAPPACHAN KOLATTUKUDY KOLATTUKUDY; Fiscal Year: 2013..This proposal is to discover targets for novel drugs that will be effective against latent TB. Such drugs are required to get complete cure and global eradication of TB. ..
- Th17 Cytokines and Lung ImmunityJay K Kolls; Fiscal Year: 2013..We have identified a novel T-cell population that plays a critical role in defense against pneumonia. This application will explore how these cells are generated and how they control host defense in the lung. ..
- Uncontrolled diabetes, immune dysregulation and tuberculosisBlanca I Restrepo; Fiscal Year: 2010..This is the first step towards understanding the biological basis of the association between these two diseases, and therefore designing strategies to manage these patients more efficiently. ..
- Effect of Crohn's Disease Risk Alleles on Enteric MicrobiotaEllen Li; Fiscal Year: 2010....
- Project CLEAR - Changing Lives by Eradicating Antibiotic ResistanceSusan S Huang; Fiscal Year: 2012..Findings could potentially impact best practice for the 1.8 million MRSA carriers who are discharged from U.S. hospitals each year. ..
- Synergy of Host Defense Mechanisms in the LungArturo Casadevall; Fiscal Year: 2012..Furthermore, these studies will provide information that could be used to design vaccines and new therapies based on immunological reagents such as antibodies. ..
- Non-clinical Development of Bactericidal Proteins Targeting PlagueDAVID WILLIAM MARTIN; Fiscal Year: 2010....
- Serine Proteinase Inhibitors (Serpins) in Tick Feeding and PhysiologyAlbert Mulenga; Fiscal Year: 2009..Identification of important tick proteins that regulate tick physiology and facilitate tick feeding is important before alternative tick control methods can be developed. ..
- Modernization and Transformation of the New Jersey Medical School Central ResearcRobert L Johnson; Fiscal Year: 2010....
- Molecular Mechanisms Regulating Early Stage Tick FeedingAlbert Mulenga; Fiscal Year: 2012..Identification of important tick proteins that regulate tick physiology and facilitate tick feeding is important before alternative tick control methods can be developed. ..
- Omics for TB Disease Progression (OTB)David R Sherman; Fiscal Year: 2013..This project combines separate advances in systems biology and network modeling to produce an experimentally grounded and verifiable systems-level model of the host regulatory networks that affect TB progression. ..
- Obesity, Aging, and Cancer Cost (OACC) StudyBenjamin M Craig; Fiscal Year: 2010....
- Innate Immunity and SIV InfectionAftab A Ansari; Fiscal Year: 2013..Studies are therefore focused on defining these early events in SIV infected monkeys. ..
- Molecular determinants of virulent arenavirus infection in hostsYuying Liang; Fiscal Year: 2013..We propose here to study the molecular mechanisms by which some arenaviruses can cause virulent infections in the hosts. These studies may lead to the development of effective treatments against the deadly arenavirus HF in humans. ..
- Emerging Infectious Diseases Training ProgramKathleen A McDonough; Fiscal Year: 2013..This application proposes to train pre- and postdoctoral scientists to combat such threats to the nation's public health. ..
- Mechanisms of CD8+ T cell Immune surveillance in human genital skin and mucosa afJia Zhu; Fiscal Year: 2012....
- Non-invasive Optical Imaging of Select Agent Bacteria in Non-human PrimatesFrederick D Quinn; Fiscal Year: 2010..PHS 398/2650 (Rev. 11/07) Page 12 Continuation Format Page ..
- Drug Cost Containment Changes and Quality of Care for Mentally Ill Dual EnrolleesStephen B Soumerai; Fiscal Year: 2012..In Aim 3 we will use both designs to examine the impact of the policy changes among at-risk subgroups (defined by somatic comorbidities and minority status) of patients with schizophrenia and bipolar disorder. ..
- MicroRNA marker-based prognosis of oral cancer survivalANGELA JIYEON YOON; Fiscal Year: 2013..Through this R03 program for the new investigators, the candidate will reach her long-term goal of becoming an independent investigator with expertise in the management of oral cancer. ..
- Innovative Device to Improve Safety of Preparing and Administering ChemotherapyPrasad Sunkara; Fiscal Year: 2013....
- Vascular Delivery of alpha-Sarcoglycan for LGMD2DJERRY ROY MENDELL; Fiscal Year: 2013..The outcome measures proven to be satisfactory and used extensively in our clinical trials program will determine efficacy of this approach. ..
- Dissemination of a Diabetes Prevention Program among Medicare Eligible RetireesELIZABETH MARY VENDITTI; Fiscal Year: 2013..Finally, exploratory analyses will document program costs and program impact on medical utilization. ..
- Intra-bladder MMC &suramin for nonmuscle-invading &locally advanced bladder caZe Lu; Fiscal Year: 2012..Given the extremely high lifetime health care costs for these patients (over $10 billion in 2003 dollars), an additional potential benefit is cost containment. ..
- Biological Models of Influenza A VirusGilles Clermont; Fiscal Year: 2010....
- Regulation of Apoptotic Envelope Formation by MTB in the Host MacrophageHEINZ GERNOT REMOLD; Fiscal Year: 2010..These studies will enhance our knowledge about critical host-pathogen interactions in tuberculosis that could foster development of novel approaches to treatment and prevention. ..
- WHONET for automated real-time multilevel global microbial surveillanceJohn Stelling; Fiscal Year: 2013....
- CTL and HIV Polymorphisms in Heterosexual TransmissionJianming Tang; Fiscal Year: 2013..A clear understanding of this virus-host interplay will benefit the ultimate goal of developing preventive tools that can reduce the further spread of HIV- 1 infection. ..
- Preclinical development of recombinant antigen diagnostics for Lassa feverRobert F Garry; Fiscal Year: 2013..The impact of Lassa fever in endemic areas of West Africa is immense, and a safe and effective diagnostic can also provide a very significant public health benefit. ..
- Influenza and Other Emerging Infectious Diseases in Vietnam (U01)HIEN TRAN NGUYEN; Fiscal Year: 2013....
- Resolution of inflammation in healing myocardial infarctsNikolaos G Frangogiannis; Fiscal Year: 2013..In addition, the novel effects of IRAK-M on fibroblast function and its potential interactions with the TGF- [unreadable] pathway have important implications in the biology of tissue inflammation and repair. ..
- Translational Regulation of Gene Expression in Neonatal PMNsChristian Con Yost; Fiscal Year: 2010..Results of these experiments will provide new and important mechanistic insight into the pathogenesis of NEC, and may lead to improvements in the prevention and treatment of this common and often devastating disease of prematurity. ..
- Comparative Effectiveness of Dementia Care Strategies in Underserved CommunitiesBARBARA G contact VICKREY; Fiscal Year: 2010....
- The Pathogenesis of Brain AbscessTAMMY L KIELIAN; Fiscal Year: 2013..Conceivably, this approach could lead to significant improvements in clinical outcomes and quality of life for patients recovering from brain abscesses. ..
- Effects of acute ethanol exposure on post burn intestinal immunity: role of IL-23Juan Luis Rendón; Fiscal Year: 2013..The proposed studies will potentially provide a mechanism by which alcohol complicates burn injury and reveal valuable therapeutic targets to improve the care of patients who sustain injury following exposure to alcohol. ..
- IVIS Spectrum CT Imaging System in BSL-3 ContainmentKATHERINE D RYMAN; Fiscal Year: 2013..The diversity of pathogens and animal models available in the University of Pittsburgh RBL and the plan to integrate this IVIS Spectrum CT with existing micro PET/CT imaging capabilities provides a truly unique resource. ..
- Improving Safety and Access for Physical ActivityDawn K Wilson; Fiscal Year: 2010....
- Plant-Derived hepatitis B Vaccine from Biomanufacturing System to Clinical TrialRobert Britt; Fiscal Year: 2009....
- Acute Myeloid Leukemia: MRD Analysis Using Modular uFluidics and uFlow CytometrySteven Allan Soper; Fiscal Year: 2013..A pilot study will be performed to measure MRD status in AML patients and associate that with the onset of hematologic relapse using the designed fluidic bio-processor with results compared to MFC. ..
- Dectin-1 and Invasive Pulmonary AspergillosisChad Steele; Fiscal Year: 2010..fumigatus and will hopefully lead us to develop novel immunotherapeutic strategies to augment host defense against A. fumigatus in susceptible individuals. ..
- Maternal immune protection against congenital CMV infectionSallie R Permar; Fiscal Year: 2012..Elucidation of the maternal immune correlates of protection against congenital CMV transmission and disease is vital to the design of effective maternal vaccine strategies in preventing CMV-associated brain damage and hearing loss. ..
- Becton Dickinson FACSAria IIu Cell Sorter Flow CytometerDIMITRIOS MOSKOFIDIS; Fiscal Year: 2010....
- UW SMPH CSC L3 unit rodent containment and quarantineCALVIN C PATTEN JR.; Fiscal Year: 2011..This project will have a direct and ongoing impact on public health, by creating a better environment for our research efforts, thus furthering the study of human diseases and enabling the development of innovative treatments. ..
- Effect of Tobacco Advocacy at the State LevelSTANTON ARNOLD GLANTZ; Fiscal Year: 2013....
- S. typhimiurium Vaccine Against Bacterial EnteropathogensRoy Curtiss; Fiscal Year: 2007..abstract_text> ..
- Impact of Medicaid Policy on cardiovascular drug use and clinical outcomesMichael A Fischer; Fiscal Year: 2010....
- MECHANISMS OF EMERGENCE OF Z00NOTIC VIRAL PATHOGENSRobert Tesh; Fiscal Year: 1999..Data resulting from the research will enhance prediction, prevention and control of several emerging viral diseases occurring in the Americas. ..
- IMPROVING ENVIRONMENTAL QUALITY AND HAZARD CONTAINMENTMaarten Bosland; Fiscal Year: 2004..abstract_text> ..
- Regional Biocontainment LaboratoryJAMES GAINES; Fiscal Year: 2007..abstract_text> ..
- Genotyping assays for the most common mutations associated with abacavir hypersenBERTRAND LEMIEUX; Fiscal Year: 2009..DNA sequencing remains a complex and costly method for DNA diagnostics. The method we propose to develop would be lower cost and easy to implement in near patient settings. ..
- MEDICAID FINANCING FOR THE SEVERELY MENTALLY ILLDonald Steinwachs; Fiscal Year: 1990....
- COST CONTAINMENT & GROUP HEALTH INSURANCE BENEFIT GROWTHDouglas Coate; Fiscal Year: 1993..In addition, they contain data on the illness risk of each firm's insured employees...