constriction

Summary

Summary: The act of constricting.

Top Publications

  1. ncbi Late umbilical cord-clamping as an intervention for reducing iron deficiency anaemia in term infants in developing and industrialised countries: a systematic review
    Patrick van Rheenen
    Emma Kinderziekenhuis, Academic Medical Centre, Amsterdam, The Netherlands
    Ann Trop Paediatr 24:3-16. 2004
  2. ncbi Brain but not spinal NR2B receptor is responsible for the anti-allodynic effect of an NR2B subunit-selective antagonist CP-101,606 in a rat chronic constriction injury model
    Etsuko Nakazato
    Discovery Biology Research, Pfizer Global R and D, Nagoya Laboratories, Taketoyo, Aichi, Japan
    Pharmacology 73:8-14. 2005
  3. ncbi Sildenafil citrate and vacuum constriction device combination enhances sexual satisfaction in erectile dysfunction after radical prostatectomy
    Rupesh Raina
    Glickman Urological Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Urology 65:360-4. 2005
  4. ncbi Comparison between two methods of drain clamping after total knee arthroplasty
    Narayana Prasad
    Bombay Hospital and Postgraduate Institute, Mumbai, India
    Arch Orthop Trauma Surg 125:381-4. 2005
  5. ncbi T cell infiltration after chronic constriction injury of mouse sciatic nerve is associated with interleukin-17 expression
    Christoph Kleinschnitz
    Department of Neurology, Julius Maximilians Universitat, Josef Schneider Str 11, D 97080 Wurzburg, Germany
    Exp Neurol 200:480-5. 2006
  6. ncbi Portal triad occlusion induces endotoxin tolerance: role of portal congestion
    Naoki Unno
    Second Department of Surgery, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu, 431 3192, Japan
    J Surg Res 135:213-7. 2006
  7. ncbi Green tea pain modulating effect in sciatic nerve chronic constriction injury rat model
    Waleed M Renno
    Department of Anatomy, Faculty of Medicine, Health Sciences Centre, University of Kuwait, Safat, Kuwait
    Nutr Neurosci 9:41-7. 2006
  8. ncbi Intracisternal administration of mitogen-activated protein kinase inhibitors reduced mechanical allodynia following chronic constriction injury of infraorbital nerve in rats
    Eun J Lim
    Department of Oral Physiology and BrainKorea 21, School of Dentistry, Kyungpook National University, Daegu 700 412, South Korea
    Prog Neuropsychopharmacol Biol Psychiatry 31:1322-9. 2007
  9. ncbi A systematic review and meta-analysis of a brief delay in clamping the umbilical cord of preterm infants
    Heike Rabe
    Department of Neonatology, Brighton and Sussex University Hospitals, Brighton, UK
    Neonatology 93:138-44. 2008
  10. doi Critical role of the rostral ventromedial medulla in early spinal events leading to chronic constriction injury neuropathy in rats
    Raul Sanoja
    Instituto Venezolano de Investigaciones Cientificas, Caracas, Venezuela
    J Pain 9:532-42. 2008

Research Grants

  1. REGULATION OF PULMONARY CIRCULATION IN FETUS AND NEWBORN
    Girija G Konduri; Fiscal Year: 2013
  2. Targeting Cell Death to Prevent Ventricular Remodeling and Heart Failure
    Abhinav Diwan; Fiscal Year: 2011
  3. KCNQ Channels and Vasoconstrictor Signal Transduction
    Kenneth L Byron; Fiscal Year: 2013
  4. KINETICS OF DRUG MACROMOLECULE COMPLEX FORMATION
    PALMER WILLIAM TAYLOR; Fiscal Year: 2013
  5. Julian M Stewart; Fiscal Year: 2016
  6. Regulation of Cardiac Kv Channel Expression
    Edwin S Levitan; Fiscal Year: 2013
  7. Cellular interactions in asthma
    CHRISTOPHER DAVID CABALLERO ALLEN; Fiscal Year: 2012
  8. Antenatal betamethasone for persistent pulmonary hypertension of newborn
    Girija G Konduri; Fiscal Year: 2010
  9. Khalid Matrougui; Fiscal Year: 2014
  10. Shuying Yang; Fiscal Year: 2014

Detail Information

Publications266 found, 100 shown here

  1. ncbi Late umbilical cord-clamping as an intervention for reducing iron deficiency anaemia in term infants in developing and industrialised countries: a systematic review
    Patrick van Rheenen
    Emma Kinderziekenhuis, Academic Medical Centre, Amsterdam, The Netherlands
    Ann Trop Paediatr 24:3-16. 2004
    ..In developing countries where fetal anaemia is common, the advantages of delayed cord-clamping might be especially beneficial...
  2. ncbi Brain but not spinal NR2B receptor is responsible for the anti-allodynic effect of an NR2B subunit-selective antagonist CP-101,606 in a rat chronic constriction injury model
    Etsuko Nakazato
    Discovery Biology Research, Pfizer Global R and D, Nagoya Laboratories, Taketoyo, Aichi, Japan
    Pharmacology 73:8-14. 2005
    ..Mechanical allodynia was induced by chronic constriction injury (CCI) of the sciatic nerve in male Sprague-Dawley rats...
  3. ncbi Sildenafil citrate and vacuum constriction device combination enhances sexual satisfaction in erectile dysfunction after radical prostatectomy
    Rupesh Raina
    Glickman Urological Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Urology 65:360-4. 2005
    To assess the effectiveness of combining sildenafil citrate with a vacuum constriction device (VCD) in men (after radical prostatectomy) unsatisfied with the results of the VCD alone.
  4. ncbi Comparison between two methods of drain clamping after total knee arthroplasty
    Narayana Prasad
    Bombay Hospital and Postgraduate Institute, Mumbai, India
    Arch Orthop Trauma Surg 125:381-4. 2005
    ..To study the clinical outcome of two methods of drain clamping after total knee arthroplasty and to determine the effect on blood loss and blood transfusion...
  5. ncbi T cell infiltration after chronic constriction injury of mouse sciatic nerve is associated with interleukin-17 expression
    Christoph Kleinschnitz
    Department of Neurology, Julius Maximilians Universitat, Josef Schneider Str 11, D 97080 Wurzburg, Germany
    Exp Neurol 200:480-5. 2006
    ..analyzed the temporal gene expression pattern of IL-17A and its main regulators IL-23 and IL-15 after chronic constriction injury (CCI) of the sciatic nerve, a lesion paradigm inducing neuropathic pain, by quantitative reverse ..
  6. ncbi Portal triad occlusion induces endotoxin tolerance: role of portal congestion
    Naoki Unno
    Second Department of Surgery, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu, 431 3192, Japan
    J Surg Res 135:213-7. 2006
    ..However, administration of a sublethal dose of endotoxin results in resistance to its toxic activities. We tested the hypothesis that portal congestion due to PTO induces endotoxin tolerance...
  7. ncbi Green tea pain modulating effect in sciatic nerve chronic constriction injury rat model
    Waleed M Renno
    Department of Anatomy, Faculty of Medicine, Health Sciences Centre, University of Kuwait, Safat, Kuwait
    Nutr Neurosci 9:41-7. 2006
    We investigated the effect of green tea (GT) in unilateral chronic constriction injury (CCI) to the rat scaitic nerve...
  8. ncbi Intracisternal administration of mitogen-activated protein kinase inhibitors reduced mechanical allodynia following chronic constriction injury of infraorbital nerve in rats
    Eun J Lim
    Department of Oral Physiology and BrainKorea 21, School of Dentistry, Kyungpook National University, Daegu 700 412, South Korea
    Prog Neuropsychopharmacol Biol Psychiatry 31:1322-9. 2007
    ..the role of mitogen-activated protein kinase (MAPK) in orofacial neuropathic pain following chronic constriction injury of the infraorbital nerve (ION-CCI)...
  9. ncbi A systematic review and meta-analysis of a brief delay in clamping the umbilical cord of preterm infants
    Heike Rabe
    Department of Neonatology, Brighton and Sussex University Hospitals, Brighton, UK
    Neonatology 93:138-44. 2008
    ..The optimal timing of clamping the umbilical cord in preterm infants at birth is the subject of continuing debate...
  10. doi Critical role of the rostral ventromedial medulla in early spinal events leading to chronic constriction injury neuropathy in rats
    Raul Sanoja
    Instituto Venezolano de Investigaciones Cientificas, Caracas, Venezuela
    J Pain 9:532-42. 2008
    ..In this report, the role of the rostral ventromedial medulla (RVM) in the early events of the chronic constriction injury (CCI) model was investigated in behavioral and electrophysiological experiments...
  11. ncbi Prolonged constriction of sciatic nerve affecting oxidative stressors & antioxidant enzymes in rat
    Devarapali Varija
    Department of Zoology, Osmania University, Hyderabad, India
    Indian J Med Res 129:587-92. 2009
    ..was carried out to determine the effects of reactive oxygen species in the balance between the pro-oxidant and antioxidant levels in experimental peripheral constriction injury induced by silver wire looping of sciatic nerve of rats.
  12. doi Intrathecal herpes simplex virus type 1 amplicon vector-mediated human proenkephalin reduces chronic constriction injury-induced neuropathic pain in rats
    Wangyuan Zou
    Department of Anesthesiology, Xiangya Hospital, Central South University, Changsha 410008, PR China
    Mol Med Rep 4:529-33. 2011
    ..effect of herpes simplex virus type 1 (HSV-1) amplicon vector-mediated human proenkephalin (hPPE) on chronic constriction injury (CCI)-induced neuropathic pain in rats...
  13. doi Endothelial function assessment: flow-mediated dilation and constriction provide different and complementary information on the presence of coronary artery disease
    Tommaso Gori
    Department of Cardiology and Angiology, University Medical Center Mainz, Germany
    Eur Heart J 33:363-71. 2012
    ..It also remains unclear whether the study of endothelial function provides information that is additive to that of traditional risk factors...
  14. pmc Neurotrophic factor changes in the rat thick skin following chronic constriction injury of the sciatic nerve
    Jennifer C Peleshok
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec H3G 1Y6, Canada
    Mol Pain 8:1. 2012
    ..It is the objective of this study to delineate the distribution of the precursor form of nerve growth factor to those cell types expressing it, as well as to describe its distribution with respect to those nerve fibers responsive to it...
  15. pmc AAV-mediated knock-down of HRC exacerbates transverse aorta constriction-induced heart failure
    Chang Sik Park
    College of Life Sciences and Systems Biology Research Center, Gwangju Institute of Science and Technology GIST, Buk Gu, Gwangju, Republic of Korea
    PLoS ONE 7:e43282. 2012
    ....
  16. ncbi The effect of thalidomide treatment on vascular pathology and hyperalgesia caused by chronic constriction injury of rat nerve
    C Sommer
    Department of Neurology, University of Wurzburg, Germany
    Pain 74:83-91. 1998
    ..We conclude that preemptive treatment with a substance that blocks production of TNF reduces pain-related symptoms and pathologic vascular changes in the chronic constriction injury model of neuropathic pain.
  17. ncbi Cerebral emboli and serum S100beta during cardiac operations
    H P Grocott
    Department of Anesthesiology, Duke Heart Center, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 65:1645-9; discussion 1649-50. 1998
    ..The purpose of this investigation was to determine the correlation between cerebral microemboli and S100beta levels during cardiac operations...
  18. ncbi Pro- and anti-inflammatory cytokine gene expression in rat sciatic nerve chronic constriction injury model of neuropathic pain
    K Okamoto
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Exp Neurol 169:386-91. 2001
    ..To study the role of key pro- and anti-inflammatory cytokines in a chronic constriction model of neuropathic pain, mRNA expression of TNF, IL-1beta, IL-6, and IL-10 was quantified using competitive ..
  19. ncbi Comparison between 1-hour and 24-hour drain clamping using diluted epinephrine solution after total knee arthroplasty
    K Yamada
    Department of Orthopaedic Surgery, Komaki City Hospital, Aichi, Japan
    J Arthroplasty 16:458-62. 2001
    ..05). Two patients (9.1%) in this group required additional surgery. One-hour clamping is preferable to 24-hour clamping in the drain-clamping method for minimizing complications...
  20. ncbi Does temporary clamping of drains following knee arthroplasty reduce blood loss? A randomised controlled trial
    N Kiely
    Royal Preston Hospital, Sharoe Green Lane, Fulwood, Preston PR2 9HT, UK
    Knee 8:325-7. 2001
    ..The authors conclude that the practice of clamping drains has no benefit in routine knee arthroplasty. However, when faced with immediate brisk blood loss, the results suggest that drains can be clamped without any excess morbidity...
  21. ncbi Effect of delayed cord clamping on iron stores in infants born to anemic mothers: a randomized controlled trial
    Rajesh Gupta
    Neonatal Division, Department of Pediatrics, Maulana Azad Medical College, New Delhi 110 002, India
    Indian Pediatr 39:130-5. 2002
    ..To study the effects of cord clamping on iron stores of infants born to anemic mothers at 3 months of age...
  22. ncbi Aortic constriction exacerbates atherosclerosis and induces cardiac dysfunction in mice lacking apolipoprotein E
    Jiao Hui Wu
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill 27599 7525, USA
    Arterioscler Thromb Vasc Biol 22:469-75. 2002
    ..We have tested the effects of chronic hypertension induced by suprarenal aortic constriction on the development of atherosclerosis in apolipoprotein E-deficient (Apoe-/-) mice...
  23. ncbi Load-dependent and -independent regulation of proinflammatory cytokine and cytokine receptor gene expression in the adult mammalian heart
    Georg Baumgarten
    Winters Center for Heart Failure Research, Department of Medicine, Houston VAMC and Baylor College of Medicine, Houston, Tex 77030, USA
    Circulation 105:2192-7. 2002
    ..Although previous studies have examined the effects of acute hemodynamic pressure overload on proinflammatory cytokine gene expression, the effects of sustained hemodynamic overloading have not been examined...
  24. ncbi Circulating RBC volume, measured with biotinylated RBCs, is superior to the Hct to document the hematologic effects of delayed versus immediate umbilical cord clamping in preterm neonates
    Ronald G Strauss
    Department of Pathology, University of Iowa Roy J and Lucille A Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
    Transfusion 43:1168-72. 2003
    ..e., a fall in plasma volume concentrates RBCs to increase Hct; a rise in plasma volume dilutes RBCs to decrease Hct)...
  25. ncbi Immediate and delayed cord clamping in infants born between 24 and 32 weeks: a pilot randomized controlled trial
    Judith S Mercer
    College of Nursing, University of Rhode Island, White Hall, 2 Heathman Road, Kingston, RI 02881 2021, USA
    J Perinatol 23:466-72. 2003
    ..This pilot study's aim was to establish feasibility of a protocol for delayed cord clamping (DCC) versus immediate cord clamping (ICC) at preterm birth and to examine its effects on initial blood pressure and other outcomes...
  26. ncbi Bacterial translocation, endotoxaemia and apoptosis following Pringle manoeuvre in rats
    Kriton S Filos
    Department of Anaesthesiology and Critical Care Medicine, School of Medicine, University of Patras, Patras, Greece
    Injury 35:35-43. 2004
    ..No data exist to date on the effects of Pm on mucosal barrier dysfunction, systemic bacterial translocation (BT), endotoxaemia and apoptosis...
  27. ncbi Massive gastrointestinal bleeding complicating portal vein cross-clamping during liver transplantation
    Dominic A Cave
    Department of Anesthesiology and Pain Medicine, University of Alberta, Edmonton, Alberta, Canada
    Anesth Analg 98:935-6, table of contents. 2004
    ..This case suggests that acute intraoperative hemorrhage from a varix should always be a consideration before liver transplantation in patients who have a history of upper gastrointestinal bleeding...
  28. ncbi Mandibular midline osteotomy for constriction
    Donald R Joondeph
    Department of Orthodontics, School of Dentistry, University of Washington, Seattle, USA
    Am J Orthod Dentofacial Orthop 126:268-70. 2004
  29. ncbi The early effects of delayed cord clamping in term infants born to Libyan mothers
    Musbah Omar Emhamed
    Child and Reproductive Health Group, Liverpool School of Tropical Medicine, Liverpool, UK
    Trop Doct 34:218-22. 2004
    ..It is a safe, simple and low cost delivery procedure that should be incorporated in integrated programmes aimed at reducing iron deficiency anaemia in infants in developing countries...
  30. pmc Complete versus selective portal triad clamping for minor liver resections: a prospective randomized trial
    Juan Figueras
    Department of Surgery, Hospital Universitari de Bellvitge, University of Barcelona, Spain
    Ann Surg 241:582-90. 2005
    ..To evaluate the feasibility, safety, efficacy, amount of hemorrhage, postoperative complications, and ischemic injury of selective clamping in patients undergoing minor liver resections...
  31. ncbi The effect of umbilical venous constriction on placental development, cord length and perinatal outcome
    Svein Magne Skulstad
    Institute of Clinical Medicine, Department of Obstetrics and Gynaecology, University of Bergen, Bergen, Norway
    Early Hum Dev 81:325-31. 2005
    Umbilical vein constriction at the fetal abdominal inlet is a common finding after week 13, when the period of umbilical herniation is brought to an end.
  32. ncbi Effect of the cannabinoid CB1 receptor antagonist, SR141716, on nociceptive response and nerve demyelination in rodents with chronic constriction injury of the sciatic nerve
    Barbara Costa
    Department of Biotechnology and Bioscience, University of Milano Bicocca, Piazza della Scienza 2, 20126 Milano, Italy
    Pain 116:52-61. 2005
    ..of the selective cannabinoid receptor type 1 (CB1) antagonist, SR141716 (rimonabant), in rats with chronic constriction injury of the sciatic nerve (CCI), an animal model of neuropathic pain...
  33. ncbi Comparison between 4-hour clamping drainage and nonclamping drainage after total knee arthroplasty
    Po Chuan Shen
    Department of Orthopedics, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    J Arthroplasty 20:909-13. 2005
    ..These results suggested that clamping the drainage in the first 4 postoperative hours reduces postoperative blood loss without causing excess morbidity after total knee arthroplasty...
  34. ncbi Single crossclamp improves 6-month cognitive outcome in high-risk coronary bypass patients: the effect of reduced aortic manipulation
    John W Hammon
    Department of Cardiothoracic Surgery, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Thorac Cardiovasc Surg 131:114-21. 2006
    ....
  35. ncbi The effect of timing of cord clamping on neonatal venous hematocrit values and clinical outcome at term: a randomized, controlled trial
    José M Ceriani Cernadas
    Division of Neonatology, Department of Pediatrics, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina
    Pediatrics 117:e779-86. 2006
    ..The umbilical cord is usually clamped immediately after birth. There is no sound evidence to support this approach, which might deprive the newborn of some benefits such as an increase in iron storage...
  36. ncbi Delayed release of drain in total knee replacement reduces blood loss. A prospective randomised study
    Niloy Roy
    Royal Oldham Hospital, Oldham, Lancashire, United Kingdom
    Acta Orthop Belg 72:34-8. 2006
    ..The results show that delaying release of the drains by one hour reduces postoperative blood loss and transfusion requirement following total knee arthroplasty...
  37. pmc Delayed cord clamping in very preterm infants reduces the incidence of intraventricular hemorrhage and late-onset sepsis: a randomized, controlled trial
    Judith S Mercer
    University of Rhode Island, Kingston, RI, USA
    Pediatrics 117:1235-42. 2006
    ..Other outcome variables were late-onset sepsis (LOS) and intraventricular hemorrhage (IVH)...
  38. ncbi Effect of timing of umbilical cord clamping on iron status in Mexican infants: a randomised controlled trial
    Camila M Chaparro
    Department of Nutrition, Program in International and Community Nutrition, University of California, Davis, CA 95616 8669, USA
    Lancet 367:1997-2004. 2006
    ..We aimed to assess whether a 2-minute delay in the clamping of the umbilical cord of normal-weight, full-term infants improved iron and haematological status up to 6 months of age...
  39. ncbi Neurotrophin-3 attenuates galanin expression in the chronic constriction injury model of neuropathic pain
    T D Wilson-Gerwing
    Department of Anatomy and Cell Biology, Cameco MS Neuroscience Research Center, University of Saskatchewan, 701 Queen Street, Saskatoon, Saskatchewan, Canada S7N 5E5
    Neuroscience 141:2075-85. 2006
    ..thermal hyperalgesia and expression of molecules complicit in this behavioral response induced by chronic constriction injury (CCI) of the sciatic nerve...
  40. ncbi Spindle-shaped constriction and propagated dilation of arterioles during cortical spreading depression
    Takashi Osada
    Department of Neurology, School of Medicine, Keio University, Shinjuku ku, Tokyo, Japan
    Neuroreport 17:1365-8. 2006
    ..Although it varied in magnitude and time-course, this arteriolar behavior was observed in all six cats. Despite these changes, no associated downstream tissue microvascular flow changes were discernable...
  41. pmc A practical approach to timing cord clamping in resource poor settings
    Patrick F van Rheenen
    Paediatric Gastroenterology, Department of Paediatrics, University Medical Centre Groningen, PO Box 30001, 9700 RB Groningen, Netherlands
    BMJ 333:954-8. 2006
  42. ncbi Umbilical cord milking reduces the need for red cell transfusions and improves neonatal adaptation in infants born at less than 29 weeks' gestation: a randomised controlled trial
    S Hosono
    Dr S Hosono, Department of Paediatrics and Child Health, Nihon University School of Medicine, 30 1 Oyaguchi Itabashi, Tokyo 173 8610, Japan
    Arch Dis Child Fetal Neonatal Ed 93:F14-9. 2008
    ..To investigate the effects of umbilical cord milking on the need for red blood cell (RBC) transfusion and morbidity in very preterm infants...
  43. ncbi Neutrophils invade lumbar dorsal root ganglia after chronic constriction injury of the sciatic nerve
    N Morin
    Department of Surgery, Rhode Island Hospital, Brown Medical School, Providence, RI 02903, USA
    J Neuroimmunol 184:164-71. 2007
    ..PMN infiltration in DRG tissue sections and estimated PMN count by flow cytometry following sciatic chronic constriction injury (CCI)...
  44. ncbi Modification of classical neurochemical markers in identified primary afferent neurons with Abeta-, Adelta-, and C-fibers after chronic constriction injury in mice
    Ruth Ruscheweyh
    Department of Neurophysiology, Center for Brain Research, Medical University of Vienna, A 1090 Vienna, Austria
    J Comp Neurol 502:325-36. 2007
    ..conduction velocity (corrected for utilization time) in dorsal root ganglia taken from mice after a chronic constriction injury (CCI) of the sciatic nerve and control mice, and later stained them for IB4, SP, calcitonin gene-related ..
  45. ncbi Late vs early clamping of the umbilical cord in full-term neonates: systematic review and meta-analysis of controlled trials
    Eileen K Hutton
    Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario
    JAMA 297:1241-52. 2007
    ..With few exceptions, the umbilical cord of every newborn is clamped and cut at birth, yet the optimal timing for this intervention remains controversial...
  46. ncbi Delayed cord clamping and haemoglobin levels in infancy: a randomised controlled trial in term babies
    Patrick van Rheenen
    Department of Paediatrics, Paediatric Gastroenterology, University Medical Centre, Groningen, The Netherlands
    Trop Med Int Health 12:603-16. 2007
    ....
  47. ncbi Does a constriction ring alter ejaculation latency?
    Seyed Reza Hosseini
    Department of Urology, Tehran University of Medical Sciences, Iran
    BJU Int 100:619-20. 2007
    To assess the efficacy of a 'constriction ring' as an option for treating premature ejaculation (PE).
  48. ncbi Reorganization of dorsal root ganglion neurons following chronic sciatic nerve constriction injury: correlation with morphine and lidocaine analgesia
    Yuri Kolesnikov
    Department of Anesthesiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Eur J Pharmacol 568:124-33. 2007
    Chronic constriction injury of the sciatic nerve is an animal model for neuropathic pain. In this model, the analgesic potency of systemic morphine was significantly diminished in nerve-injured mice (ED(50) 19...
  49. doi Systematic review and meta-analysis of the effect of portal triad clamping on outcome after hepatic resection
    N N Rahbari
    Department of Surgery, University of Heidelberg, Heidelberg, Germany
    Br J Surg 95:424-32. 2008
    ..The effect of portal triad clamping (PTC) on outcome after hepatic resection is uncertain...
  50. doi Chronic doxycycline exposure accelerates left ventricular hypertrophy and progression to heart failure in mice after thoracic aorta constriction
    Laurent Vinet
    INSERM U698, G H Bichat Claude Bernard, 75877 Paris Cedex 18, France
    Am J Physiol Heart Circ Physiol 295:H352-60. 2008
    ..Therefore, we examined the influence of Dox on LV remodeling and MMP expression in mice after transverse aortic constriction (TAC). One month after TAC, cardiac hypertrophy (99% vs...
  51. doi Penile constriction devices: case report, review of the literature, and recommendations for extrication
    Jonathan Silberstein
    Department of Surgery, University of California, San Diego Medical Center, San Diego, CA, USA
    J Sex Med 5:1747-57. 2008
    Penile constriction devices often present significant challenges to urologic surgeons. Failure to remove such devices can lead to significant ischemia and loss of tissue...
  52. pmc Laryngeal constriction during hypoxic gasping and its role in improving autoresuscitation in two mouse strains
    Z Song
    Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, USA
    J Appl Physiol (1985) 106:1223-6. 2009
    ..Also, they show that SWR/J mice have a deficiency in central nervous system mechanisms regulating glottic closure during hypoxic gasping...
  53. doi Atherosclerotic plaque disruption induced by stress and lipopolysaccharide in apolipoprotein E knockout mice
    Mei Ni
    Shandong Univ Qilu Hospital, No 107, Wen Hua Xi Road, Jinan, Shandong 250012, P R China
    Am J Physiol Heart Circ Physiol 296:H1598-606. 2009
    ..Plasma fibrinogen levels were remarkably elevated in the stress and stress+LPS groups. In conclusion, stress- and LPS-costimulated apoE(-/-) mice provide a useful model for studies of plaque vulnerability and interventions...
  54. doi Hemodynamic and histomorphometric characteristics of heart failure induced by aortic stenosis in the guinea pig: comparison of two constriction sizes
    Bruno Laviolle
    Laboratoire de Pharmacologie Experimentale et Clinique, UPRES EA 3194 Groupe de recherche cardio vasculaire, Faculte de Medecine, Universite de Rennes 1, 2 Avenue du Pr Leon Bernard, 35043 Rennes, France
    Can J Physiol Pharmacol 87:908-14. 2009
    ..A 12G stenosis results in compensated hypertrophy at 60 and 120 d; a 14G stenosis leads to compensated hypertrophy at 60 d and heart failure at 120 d...
  55. doi Deficiency of the negative immune regulator B7-H1 enhances inflammation and neuropathic pain after chronic constriction injury of mouse sciatic nerve
    Nurcan Uceyler
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany
    Exp Neurol 222:153-60. 2010
    ..We analyzed the temporal gene expression profile of B7-H1 and different cytokines after chronic constriction injury (CCI) of the sciatic nerve, a lesion paradigm inducing neuropathic pain, by quantitative real-time ..
  56. pmc Chronic constriction injury reduces cannabinoid receptor 1 activity in the rostral anterior cingulate cortex of mice
    Michelle R Hoot
    Virginia Commonwealth University, Department of Pharmacology and Toxicology, Richmond, VA, USA
    Brain Res 1339:18-25. 2010
    ..Chronic constriction injury (CCI) produced a significant decrease in WIN 55,212-2-stimulated [(35)S]GTPgammaS binding in membranes ..
  57. doi Induction of heart failure by minimally invasive aortic constriction in mice: reduced peroxisome proliferator-activated receptor γ coactivator levels and mitochondrial dysfunction
    Gloria Faerber
    Department of Cardiac Surgery, University of Leipzig Heart Center, Leipzig, Germany
    J Thorac Cardiovasc Surg 141:492-500, 500.e1. 2011
    ..We assessed the suitability of minimally invasive transverse aortic constriction to induce heart failure in C57BL/6 mice and assessed mitochondrial biogenesis and function.
  58. pmc Care during the third stage of labour: a postal survey of UK midwives and obstetricians
    Diane Farrar
    Bradford Institute for Health Research, Bradford Royal Infirmary, Bradford, BD9 6RJ, UK
    BMC Pregnancy Childbirth 10:23. 2010
    ..Evidence to guide care during the third stage is limited and there is variation in recommendations which may contribute to differences in practice. This paper describes current UK practice during the third stage of labour...
  59. doi Differential effect of spironolactone in chronic constriction injury and vincristine-induced neuropathic pain in rats
    Amteshwar Singh Jaggi
    Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, India
    Eur J Pharmacol 648:102-9. 2010
    The present study was designed to investigate the ameliorative potential of spironolactone in chronic constriction injury and vincristine-induced neuropathic pain in rats...
  60. doi Risk of deep venous thrombosis in drain clamping with tranexamic acid and carbazochrome sodium sulfonate hydrate in total knee arthroplasty
    Tomohiro Onodera
    Department of Orthopaedic Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Arthroplasty 27:105-8. 2012
    ..Tranexamic acid and carbazochrome sodium sulfonate hydrate in the drain-clamping method help reduce bleeding after TKA without increasing the risk of deep venous thrombosis...
  61. doi Glial cell line-derived neurotrophic factor gene transfer exerts protective effect on axons in sciatic nerve following constriction-induced peripheral nerve injury
    Jhih Yin Shi
    Institute of Biological Sciences, National Sun Yat Sen University, Kaohsiung 804, Taiwan
    Hum Gene Ther 22:721-31. 2011
    ..effect of glial cell line-derived neurotrophic factor (GDNF) using peripheral gene delivery in a rat model of constriction-induced peripheral nerve injury...
  62. pmc Cardiac overexpression of 8-oxoguanine DNA glycosylase 1 protects mitochondrial DNA and reduces cardiac fibrosis following transaortic constriction
    Jianxun Wang
    Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Am J Physiol Heart Circ Physiol 301:H2073-80. 2011
    ..8-oxo-dG) under basal conditions, after doxorubicin administration, or after transaortic constriction (TAC), but the transgene produced no detectable reduction in nuclear 8-oxo-dG content...
  63. doi Novel extraction technique to remove a penile constriction device
    Darren J Katz
    Department of Urology, Monash Medical Centre, Southern Health, Melbourne, Australia
    J Sex Med 9:937-40. 2012
    ..Penile strangulation can be a challenging clinical situation and usually requires prompt treatment. The clinician should be aware of the various techniques to remove such devices...
  64. doi Low-level laser therapy alleviates neuropathic pain and promotes function recovery in rats with chronic constriction injury: possible involvements in hypoxia-inducible factor 1α (HIF-1α)
    Yueh Ling Hsieh
    Department of Physical Therapy, Graduate Institute of Rehabilitation Science, China Medical University, Taichung, Taiwan 40402
    J Comp Neurol 520:2903-16. 2012
    ..These findings might lead to a sufficient morphological and functional recovery of the peripheral nerve...
  65. doi Exercise training attenuates neuropathic pain and cytokine expression after chronic constriction injury of rat sciatic nerve
    Yu Wen Chen
    Department of Physical Therapy, China Medical University, Taichung, Taiwan
    Anesth Analg 114:1330-7. 2012
    ..whether physical exercise regulates the functional recovery and heat shock protein 72 (Hsp72), tumor necrosis factor-α (TNF-α), and interlukin-1β (IL-1β) expression after chronic constriction injury (CCI) of the sciatic nerve.
  66. doi Evaluation of aqueous and ethanolic extracts of saffron, Crocus sativus L., and its constituents, safranal and crocin in allodynia and hyperalgesia induced by chronic constriction injury model of neuropathic pain in rats
    Bahareh Amin
    Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
    Fitoterapia 83:888-95. 2012
    ..ethanolic and aqueous extracts of saffron as well as its bioactive ingredients, safranal and crocin, in chronic constriction injury (CCI)-induced neuropathic pain in rats...
  67. doi Effect of periaqueductal gray melanocortin 4 receptor in pain facilitation and glial activation in rat model of chronic constriction injury
    Haichen Chu
    Department of Anesthesiology, Affiliated Hospital of Medical College, Qingdao University, China
    Neurol Res 34:871-88. 2012
    ..This research will choose PAG to discuss the effect of MC4R in pain facilitation induced by chronic constriction injury (CCI) and further discuss its effect in glial activity and inflammatory factor levels in nerve injury.
  68. ncbi Ameliorative potential of Butea monosperma on chronic constriction injury of sciatic nerve induced neuropathic pain in rats
    Venkata R K Thiagarajan
    School of Chemical and Biotechnology, SASTRA University, Thanjavur, Tamilnadu, India
    An Acad Bras Cienc 84:1091-104. 2012
    ..designed to investigate the ameliorative role of ethanolic extract from leaves of Butea monosperma in chronic constriction injury (CCI) of sciatic nerve induced neuropathic pain in rats...
  69. pmc Intra-articular injection of tranexamic acid via a drain plus drain-clamping to reduce blood loss in cementless total knee arthroplasty
    Hirotaka Mutsuzaki
    Department of Orthopaedic Surgery, Ibaraki Prefectural University of Health Sciences, 4669 2 Ami, Ami Machi, Inashiki Gun, Ibaraki 300 0394, Japan
    J Orthop Surg Res 7:32. 2012
    ..In a retrospective study, we explored whether postoperative intra-articular retrograde injection of tranexamic acid (TA) and leaving a drain clamp in place for 1 h reduced blood loss...
  70. doi microRNA changes in the dorsal horn of the spinal cord of rats with chronic constriction injury: A TaqMan® Low Density Array study
    Yuuki Genda
    Department of Anaesthesiology and Pain Medicine, Graduate School of Medicine, Nippon Medical School, Bunkyo ku, Tokyo 113 8603, Japan
    Int J Mol Med 31:129-37. 2013
    ..this possibility by analyzing miRNA expression in the dorsal horn of the spinal cord in a chronic constriction injury (CCI) rat model using the TaqMan® Low Density Array (TLDA)...
  71. doi Temporal distribution of p300/CBP immunoreactivity in the adult rat spinal dorsal horn following chronic constriction injury (CCI)
    Xiao yan Zhu
    Department of Anesthesiology, Xiangya Hospital of Central South University, Changsha, Hunan, China
    Cell Mol Neurobiol 33:197-204. 2013
    ..in this study, their spatiotemporal distribution in the spinal cord of adult rat following chronic constriction injury (CCI) was studied. p300 and CBP expressed predominantly in nuclei in the gray matter of rat spinal cord...
  72. doi Effects of chronic administration of amitriptyline, gabapentin and minocycline on spinal brain-derived neurotrophic factor expression and neuropathic pain behavior in a rat chronic constriction injury model
    Pascal Vanelderen
    Department of Anesthesiology, Intensive Care, Emergency Care and Pain Therapy, Ziekenhuis Oost Limburg, Genk, Belgium
    Reg Anesth Pain Med 38:124-30. 2013
    ..No data are available on the effect of amitriptyline and gabapentin on spinal BDNF expression. If the mechanism of action of the latter drugs does not involve brain-derived NP inhibition, further clinical research in BDNF is warranted...
  73. pmc Satellite glial cell proliferation in the trigeminal ganglia after chronic constriction injury of the infraorbital nerve
    Macayla Donegan
    University of California San Francisco, Center for Integrative Neuroscience, Box 0444, 675 Nelson Rising Lane, San Francisco, California
    Glia 61:2000-8. 2013
    We have examined satellite glial cell (SGC) proliferation in trigeminal ganglia following chronic constriction injury of the infraorbital nerve...
  74. pmc Apical constriction: themes and variations on a cellular mechanism driving morphogenesis
    Adam C Martin
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Development 141:1987-98. 2014
    Apical constriction is a cell shape change that promotes tissue remodeling in a variety of homeostatic and developmental contexts, including gastrulation in many organisms and neural tube formation in vertebrates...
  75. ncbi Repair of traumatic aortic rupture: a 25-year experience
    A J Razzouk
    Division of Cardiothoracic Surgery, Loma Linda University, 11175 Campus St, Suite 21121, Loma Linda, CA 92354, USA
    Arch Surg 135:913-8; discussion 919. 2000
    ..Surgical management of traumatic aortic rupture (TAR) is controversial, specifically whether distal aortic perfusion modifies the outcome...
  76. ncbi Differential activation of MAPK in injured and uninjured DRG neurons following chronic constriction injury of the sciatic nerve in rats
    Koichi Obata
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Eur J Neurosci 20:2881-95. 2004
    ..kinase (ERK) and p38 mitogen-activated protein kinase (MAPK) in the dorsal root ganglion (DRG) in the chronic constriction injury (CCI) model...
  77. ncbi Hemostatic alterations associated with supraceliac aortic cross-clamping
    Petros V Anagnostopoulos
    Department of Surgery, Division of Vascular Surgery and Department of Pathology, Henry Ford Hospital, 2799 West Grand Blvd, Detroit, MI 48202, USA
    J Vasc Surg 35:100-8. 2002
    ..However, t-PA Ag levels reflect both active and inactive (bound to serum t-PA inhibitors) forms of serum t-PA, and elevations confirm the presence of fibrinolysis only in conjunction with an increase in t-PA activity...
  78. ncbi A spinal thecal sac constriction model supports the theory that induced pressure gradients in the cord cause edema and cyst formation
    A Josephson
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Neurosurgery 48:636-45; discussion 645-6. 2001
    ..A hypothesis that could explain how spinal cord cysts form in these situations has been presented recently. Therefore, a novel spinal thecal sac constriction model was implemented to test various aspects of this hypothesis.
  79. ncbi [Neurological complications of aortic artery surgery]
    Y Carrascal
    , Hospital 12 de Octubre, Madrid,
    Rev Neurol 27:854-61. 1998
    ..Neurological damage continues to be the main cause of morbi-mortality in patients with dissection or aneurysm of the aorta...
  80. ncbi Divergent effects of ischemia/reperfusion and nitric oxide donor on TNFalpha mRNA accumulation in rat organs
    M A Rahat
    Immunology Research Unit, Lady Davis Carmel Medical Center, Rappaport Family Institute for Research in the Medical Sciences, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa
    Shock 15:312-7. 2001
    ..The divergent organ pattern of TNFalpha transcription emphasizes the importance of its localized expression, which is critical to the understanding of its autocrine and paracrine actions in ischemia and reperfusion...
  81. ncbi Diethylmaleate, a pro-oxidant, attenuates experimental ischaemia-reperfusion-induced lung injury
    P D Kiely
    Department of Surgery, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland
    Br J Surg 89:482-5. 2002
    ..The aim of this study was to evaluate whether DEM could have a protective effect on neutrophil-mediated lung injury in an animal model of lower-torso IR...
  82. ncbi Clinically relevant thermal preconditioning attenuates ischemia-reperfusion injury
    P H McCormick
    Department of Surgery, Royal College of Surgeons of Ireland, Beaumont Hospital, 9 Dublin, Republic of Ireland
    J Surg Res 109:24-30. 2003
    ..Our aim was thus to establish a novel and clinically applicable method of preconditioning...
  83. ncbi Effects of TVE application during 70% hepatectomy on regeneration capacity of rats
    Serdar Topaloglu
    First Department of Surgery, Ankara Numune Training and Research Hospital, 06100 Sihhiye, Ankara, Turkey
    J Surg Res 124:139-45. 2005
    ..This study was planned to compare the effects of liver resections performed either with portal pedicle clamping or with TVE on the regeneration process...
  84. ncbi Ischemic preconditioning versus intermittent vascular inflow control during major liver resection in pigs
    Vassilios Smyrniotis
    Second Department of Surgery, School of Medicine, Areteion Hospital, Athens University, Athens, Greece
    World J Surg 29:930-4. 2005
    ..51 vs. 2.85 +/- 1.16; p = 0.04) compared to the IPC group. It appears that IPC should be employed when liver ischemia is anticipated to last less than 90 minutes, followed by IVC when the liver ischemia is expected to last 120 minutes...
  85. ncbi Effects of ulinastatin on pulmonary artery pressure during abdominal aortic aneurysmectomy
    Saori Kurosawa
    Department of Anesthesiology, Sapporo Medical University School of Medicine, Sapporo 060 8543, Japan
    J Clin Anesth 18:18-23. 2006
    ..We examined whether ulinastatin, a urinary trypsin inhibitor, prevents ischemia-reperfusion injury and increase in PAP after aortic unclamping (XU) during AAAectomy...
  86. ncbi Alpha glutathione S-transferase: a potential marker of ischemia-reperfusion injury of the intestine after cardiac surgery?
    Morgan P McMonagle
    Department of Paediatric Surgery, Our Lady s Hospital for Sick Children, Crumlin, Dublin 12, Ireland
    J Pediatr Surg 41:1526-31. 2006
    ..The aim of the study was to assess the utility of alpha glutathione S-transferase (alphaGST) as a potential marker of intestinal ischemia-reperfusion injury in children after cardiac surgery...
  87. ncbi Loss of renal function and microvascular blood flow after suprarenal aortic clamping and reperfusion (SPACR) above the superior mesenteric artery is greatly augmented compared with SPACR above the renal arteries
    Stuart I Myers
    McGuire Research Institute McGuire VA Medical Center, Richmond, VA, USA
    J Vasc Surg 45:357-66. 2007
    ..This study examined the hypothesis that SMA-SRACR-induced downregulation of renal blood flow and function is more severe than renal-SRACR owing to the addition of systemic oxygen-derived free radical (ODFR) release...
  88. doi Preconditioning, but not postconditioning, with Sevoflurane reduces pulmonary neutrophil accumulation after lower body ischaemia/reperfusion injury in rats
    R Kalb
    Heinrich Heine University Dusseldorf, Department of Anaesthesiology, Dusseldorf, Germany
    Eur J Anaesthesiol 25:454-9. 2008
    ..We tested the hypothesis that pre- or postconditioning with Sevoflurane attenuates pulmonary neutrophil accumulation after ischaemia/reperfusion injury of the aorta...
  89. ncbi Regional blood flow occlusion during extensive pelvic procedures for ovarian cancer: a randomized trial
    S M Eisenkop
    Women s Cancer Center Encino Tarzana, Tarzana, CA, USA
    Int J Gynecol Cancer 14:699-705. 2004
    ..There were no immediate or delayed complications due to aortic clamping. Aortic occlusion significantly reduces the blood loss and operative time for patients requiring MPE in the context of primary cytoreductive operations...
  90. ncbi Ischemic preconditioning versus intermittent vascular occlusion in liver resections performed under selective vascular exclusion: a prospective randomized study
    Vassilios Smyrniotis
    Second Department of Surgery, University of Athens, School of Medicine, Areteion Hospital, 76 Vas Sofias Av, 115 28, Athens, Greece
    Am J Surg 192:669-74. 2006
    ..The aim of this study was to compare ischemic preconditioning with the intermittent vascular occlusion technique in liver resections performed under inflow and outflow occlusion...
  91. ncbi Use of partial cardiopulmonary bypass for coarctation repair through a left thoracotomy in children without collaterals
    Carl L Backer
    Division of Cardiovascular Thoracic Surgery, Children s Memorial Hospital, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60614, USA
    Ann Thorac Surg 82:964-72. 2006
    ..We reviewed the results with that strategy and compared this CPB group with COA repairs in which CPB was not used to see whether there was any increase in morbidity or delay in recovery...
  92. ncbi Regulation of cardiac and skeletal muscle malonyl-CoA decarboxylase by fatty acids
    M E Young
    Division of Cardiology, Department of Internal Medicine, University of Texas-Houston Medical School, Houston, TX 77030, USA
    Am J Physiol Endocrinol Metab 280:E471-9. 2001
    ..The results suggest that fatty acids induce the expression of MCD in rat heart and skeletal muscle. Additional posttranscriptional mechanisms regulating MCD activity appear to exist...
  93. ncbi Effect of cardiopulmonary bypass and aortic clamping on functional residual capacity and ventilation distribution in children
    Britta S von Ungern-Sternberg
    Pediatric Anesthesia Unit, Geneva Children s Hospital, Geneva, Switzerland
    J Thorac Cardiovasc Surg 134:1193-8. 2007
    ....
  94. ncbi Reduced endothelial vascular relaxation in growth-restricted offspring of pregnant rats with reduced uterine perfusion
    Jason A Payne
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Miss, USA
    Hypertension 42:768-74. 2003
    ..NO-mediated vascular relaxation is inhibited in IUGR offspring of pregnant rats with reduced uteroplacental perfusion, and this may explain the increased vascular constriction and arterial pressure in young adults with low birth weight.
  95. ncbi Renal fibrosis in diabetic and aortic-constricted hypertensive rats
    B Gallego
    , , 37007 Salamanca, Spain
    Am J Physiol Regul Integr Comp Physiol 280:R1823-9. 2001
    ..in rats with diabetes and hypertension is due to hemodynamic or metabolic changes, a progressive aortic constriction between the two renal arteries has been done in streptozotocin-induced diabetic rats (constriction + diabetes ..
  96. ncbi Evaluation of a rat model of preeclampsia for HELLP syndrome characteristics
    Christy M Isler
    Department of Obstetrics and Gynecology, East Carolina University Brody School of Medicine, Greenville, North Carolina, USA
    J Soc Gynecol Investig 10:151-3. 2003
    ..To determine whether a rat model of preeclampsia includes features consistent with HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome...
  97. ncbi Pressure-independent effects of angiotensin II on hypertensive myocardial fibrosis
    Keisuke Tokuda
    Department of Internal Medicine III and Cardiovascular Research Institute, Kurume University School of Medicine, Kurume, Japan
    Hypertension 43:499-503. 2004
    ..PO was induced by suprarenal aortic constriction (AC) at day 0 in male Wistar rats, and they were orally administered 0...
  98. pmc Complex blunt aortic injury or repair: beneficial effects of cardiopulmonary bypass use
    Preston R Miller
    Department of Surgery, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27514, USA
    Ann Surg 237:877-83; discussion 883-4. 2003
    ..Special consideration is given to the influence of bypass in the outcome of complex injuries or repair circumstances...
  99. ncbi Is there a threshold duration of vascular occlusion for hindlimb reactive hyperemia?
    Jennifer Rogers
    Department of Exercise Science, University of Iowa, Iowa City, IA 52242, USA
    J Appl Physiol 99:1272-7. 2005
    ....
  100. ncbi Cardiomyocyte apoptosis and duration of aortic clamping in pig model of open heart surgery
    Markus Malmberg
    Research Centre of Applied and Preventive Cardiovascular Medicine, Turku University, FIN 20520 Turku, Finland
    Eur J Cardiothorac Surg 30:480-4. 2006
    ..The purpose of this study was to determine whether occurrence of cardiomyocyte apoptosis is related to the duration of aortic clamping in experimental pig model of cardiac surgery with cardiopulmonary bypass...
  101. ncbi Performance evaluation of a new pulse oximeter during mild hypothermic cardiopulmonary bypass
    Kazuo Irita
    Department of Anesthesiology and Critical Care Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Anesth Analg 96:11-4, table of contents. 2003
    ....

Research Grants79

  1. REGULATION OF PULMONARY CIRCULATION IN FETUS AND NEWBORN
    Girija G Konduri; Fiscal Year: 2013
    ..Studies in a fetal lamb model of PPHN, induced by prenatal ductal constriction demonstrated a decrease in NO release and increase in oxidative stress in pulmonary arteries...
  2. Targeting Cell Death to Prevent Ventricular Remodeling and Heart Failure
    Abhinav Diwan; Fiscal Year: 2011
    ..We have developed and validated the technique of transverse aortic constriction. Thus, in these studies, mice with combined forced cardiac expression and cardiac specific deletion of Nix and ..
  3. KCNQ Channels and Vasoconstrictor Signal Transduction
    Kenneth L Byron; Fiscal Year: 2013
    ..The effects of these drugs on arterial constriction and their role as mediators of vasoconstrictor hormone action (demonstrated for the first time in our ..
  4. KINETICS OF DRUG MACROMOLECULE COMPLEX FORMATION
    PALMER WILLIAM TAYLOR; Fiscal Year: 2013
    ..expand to presumed non-competitive sites on this molecule, in particular the vestibule leading into the channel constriction and the non-a subunit interfaces that do not bind agonist...
  5. Julian M Stewart; Fiscal Year: 2016
    ..central hypovolemia results from splanchnic blood pooling due to defective splanchnic arterial and venous constriction. Preliminary data support the hypothesis that production of nitric oxide (NO) is enhanced in these patients ..
  6. Regulation of Cardiac Kv Channel Expression
    Edwin S Levitan; Fiscal Year: 2013
    ..preliminary experiments suggest that AUF1 knockout mice are compromised in their response to transverse aortic constriction (TAC), showing that AUF1 is important for the in vivo cardiac response to pressure overload...
  7. Cellular interactions in asthma
    CHRISTOPHER DAVID CABALLERO ALLEN; Fiscal Year: 2012
    DESCRIPTION (Provided by the applicant) Abstract: Asthma is a lung disease that causes constriction of the airways in response to triggers such as pollen, mold, viral infection, or even cold air...
  8. Antenatal betamethasone for persistent pulmonary hypertension of newborn
    Girija G Konduri; Fiscal Year: 2010
    ..Studies in fetal lambs with prenatal ductal constriction, a model that mimics PPHN, have shown that pulmonary vascular dysfunction is associated with an increase in ..
  9. Khalid Matrougui; Fiscal Year: 2014
    ..has been shown to be critical in the development of microvascular myogenic tone expressed as microvascular constriction in response to pressure increases...
  10. Shuying Yang; Fiscal Year: 2014
    ..Both diseases have severe bone abnormalities including shortening of the long bones and constriction of the thoracic cage. However, it is unclear how IFT80 mutation leads to skeletal abnormalities...
  11. Matthew J Campen; Fiscal Year: 2016
    ..ambient air pollution, may have pathological vasoactive properties by blunting coronary dilation and enhancing constriction. ECG and vascular abnormalities in ApoE-/- mice occurred when exposed by inhalation to fresh diesel or gasoline ..
  12. WILLIAM BRYSON CAMPBELL; Fiscal Year: 2014
    ..Agonists such as norepinephrine and angiotensin promote constriction by activating the RhoA-Rho kinase cascade that sensitizes contractile proteins to Ca...
  13. CHERRY P WONGTRAKOOL; Fiscal Year: 2014
    ..exposure can promote airway hyperresponsiveness (AHR), a characteristic feature of asthma defined as airway constriction after exposure to a provocational agent...
  14. Pulmonary Vasoreactivity Following Chronic Hypoxia
    Thomas C Resta; Fiscal Year: 2012
    ..Aim #1: Identify the intracellular signaling mechanism responsible for elevated myogenic and agonist-dependent constriction following CH...
  15. WILLIAM BRYSON CAMPBELL; Fiscal Year: 2015
    ..APA may determine whether ZG cell-mediated EET- and/or endothelial-mediated NO mechanisms oppose the constriction by AII and maintain ABF in high renin states.
  16. Isoform specific effects of the autoinhibitory element and the C-terminus of nitr
    JOHN SALERNO; Fiscal Year: 2009
    ..The endothelial isoform of NOS (eNOS) controls vascular constriction and dilation and has effects on platelet aggregation, with pathologies including hypertension and other ..
  17. Jian Wang; Fiscal Year: 2014
    ..been found to enhance calcium signaling in pulmonary artery smooth muscle cells, causing cell proliferation and constriction. Our study focuses on investigation of whether and how BMP4 regulates this process, which, if successful, will ..
  18. NO-Zinc Signaling in Intact Pulmonary Endothelium
    CLAUDETTE MARIE ST CROIX; Fiscal Year: 2010
    ..We will examine the role of NO- MT-Zn on constriction of the microcirculation via intravital microscopy of subpleural vessels of IPLs from TIE- 2-GFP and MT and eNOS ..
  19. Zsolt Bagi; Fiscal Year: 2014
    ..application led to my main hypothesis that small coronary arteries of diabetic patients exhibit a paradoxical constriction to sudden increases in flow, an alteration, which contributes to no reflow...
  20. DOMINIC AARON SILER; Fiscal Year: 2015
    ..Delayed microvascular spasm, a constriction of small resistance vessels and capillaries in the brain by an unknown cause, is associated with a significant ..
  21. MYOCARDIAL PERFUSION IN THE HYPERTROPHIED HEART
    ROBERT JAMES BACHE; Fiscal Year: 2010
    ..2 or SUR that result in ATP-insensitive KATP channels will be subjected to transverse aortic constriction to determine whether lack of KATP channel activity exacerbates myocardial hypertrophy and LV dysfunction, or ..
  22. Enhancement of Coronary Constriction by Volatile Organic Air Toxics
    Matthew J Campen; Fiscal Year: 2013
    ..Successful completion of these Aims will identify new pathways that mediate transference of air pollution toxicity to systemic vasculature that contributes to cardiovascular morbidity. ..
  23. Peter A Campochiaro; Fiscal Year: 2014
    ..mutations leads to death of rods resulting in night blindness followed by gradual death of cones causing constriction of visual fields and eventual blindness...
  24. The conditional GPR30 knockout mouse: a model of female-specific cardiac aging
    Leanne Groban; Fiscal Year: 2013
    ..of GPR30 in hearts from adult female mice exposed to chronic hemodynamic overload induced by transverse aortic constriction. To attain this objective, we will test the working hypothesis thatin the absence of cardiac GPR30, impairments ..
  25. Role of CaMKII Phosphorylation of RyR in Pathological &Physiological Hypertrophy
    Jonathan L Respress; Fiscal Year: 2011
    ..Methods include echocardiography, transverse aortic constriction (TAC), intracardiac hemodynamic measurements, cell isolation and confocal microscopy, MRI, exercise/treadmill ..
  26. Intrauterine chronic hypoxia and ryanodine receptors in fetal pulmonary arteries
    Sean M Wilson; Fiscal Year: 2013
    ..The fundamental focus is that ryanodine receptors (RyR) are central to the process of pulmonary arterial constriction in response to acute alveolar hypoxia, which can be dysregulated in individuals with pulmonary hypertension...
  27. Cytochrome P4501A1 and Vascular Injury
    Mary K Walker; Fiscal Year: 2012
    ..vascular function independently of increases in blood pressure by evaluating endothelial-dependent dilation and constriction in mesenteric arteries ex vivo prior to increases in blood pressure...
  28. Susan Lowey; Fiscal Year: 2016
    ..used along with in vitro studies to examine the role of actin filament cross-linking by a-actinin during ring constriction and remodeling...
  29. CATHERINE LAURA PASSARIELLO; Fiscal Year: 2015
    ..I propose to stress a new cardiac-specific mAKAP[unreadable] knock-out mouse by transverse aortic constriction and phenylephrine/angiotensin infusion via osmotic pump...
  30. Role of Endothelin System and NAD(P)H Oxidase in Retinal Arteriolar Dysfunction
    Travis W Hein; Fiscal Year: 2012
    ..elevated intraocular pressure (IOP) impaired bradykinin-induced NO-mediated dilation and enhanced ET-1-mediated constriction in pig retinal arterioles...
  31. Role of Serotonin in Smypathetic Function
    Karie E Scrogin; Fiscal Year: 2012
    ..It is further proposed that the preferential constriction of the venous vasculature induced by 5-HT1A receptor activation will produce less reperfusion injury during ..
  32. Crina M Nimigean; Fiscal Year: 2016
    ..block for MthK will be compared to similar experiments for KcsA, a channel known to gate with a bundle-crossing constriction. The proposed aims will provide important new insights into the fundamental nature of potassium channel ..
  33. Role of natriuretic peptides in the ductus arteriosus
    JOHN JEFFREY REESE; Fiscal Year: 2013
    ..to prevent postnatal closure);the response to fetal exposure to NP receptor antagonists (to induce fetal DA constriction);and the effect of NP antagonists on mouse models of PDA (to induce PDA constriction in neonates)...
  34. The role of SP-A in Mp-induced exacerbations during allergic airway disease.
    JULIE GUNNELLS LEDFORD; Fiscal Year: 2013
    ..My previous work shows that mice lacking SP-A have increased airway constriction during Mp infection compared to WT mice and that inhibition of TNF-? transcription reduces their responses...
  35. Paul C Simpson; Fiscal Year: 2016
    ..cancer drug doxorubicin), ischemic CM (post-myocardial infarction), and pressure overload CM (transverse aortic constriction)...
  36. Role of BK subunits in ethanol-cholesterol synergistic inhibition of BK channel
    Anna Bukiya; Fiscal Year: 2011
    ..Cerebrovascular ischemia results from impaired vasodilation and/or enhanced constriction of cerebral arteries...
  37. David B Jacoby; Fiscal Year: 2016
    ..We have recently shown that stimulating TLR-7 and TLR-8 relaxes airway smooth muscle and prevents broncho-constriction in response to a variety of stimuli...
  38. Nikki L Jernigan; Fiscal Year: 2016
    ..associated with obstructive pulmonary disease and sleep apnea often results in generalized pulmonary arterial constriction and vascular remodeling, subsequent pulmonary hypertension and right heart failure...
  39. Paracrine Regulation of BPH Pathogeneis
    SIMON HAYWARD; Fiscal Year: 2009
    ..Clinically BPH results in urethral constriction with a consequent slowing of urinary flow rates and an inability to properly empty the urinary bladder...
  40. Paracrine Regulation of BPH Pathogenesis
    Simon W Hayward; Fiscal Year: 2013
    ..Clinically BPH results in urethral constriction with a consequent slowing of urinary flow rates and an inability to properly empty the urinary bladder...
  41. Role of serum- and glucocorticoid-regulated kinase-1 in electrical remodeling
    Anthony Rosenzweig; Fiscal Year: 2013
    ..In a model of cardiac hypertrophy and heart failure induced by transverse aortic constriction (TAC), SGK1-DN TGs are substantially protected against cardiac dysfunction and fibrosis...
  42. Regulation of cell division in Trypanosoma brucei
    Ziyin Li; Fiscal Year: 2011
    ..Unlike animal cells that divide along the shortest cellular axis through constriction of an actomyosin contractile ring (Oliferenko et al., 2009), cytokinesis in T...
  43. ARUNI BHATNAGAR BHATNAGAR; Fiscal Year: 2015
    ..hypothesis we will examine 4-hydroxyalkenal formation and metabolism in hearts subjected to transverse aortic constriction (TAC) and we will measure changes in the activity and the levels of aldehyde-metabolizing enzymes and cellular ..
  44. RAJASEKARAN NAMAKKAL SOORAPPAN; Fiscal Year: 2016
    ..RS on cardiac function, structural remodeling and stress- induced cardiac hypertrophy in mice with trans-aortic constriction. Next, we will study the effect of RS on redox potential of ER and investigate the mechanisms associated with ..
  45. Murine slow onset outlet obstruction as a model of human voiding dysfunction
    Ronald W Wood; Fiscal Year: 2010
    ..tightening a ligature around the urethra, resulting in onset of Dl in a few weeks;instant onset of urethral constriction is likely to differ importantly from partial outlet obstruction that takes five or more decades to develop in ..
  46. Interleukin-33 and Myocardial Pressure Overload
    Richard T Lee; Fiscal Year: 2013
    ..and that wildtype mice treated with recombinant IL-33 have reduced cardiac fibrosis after transverse aortic constriction. These preliminary data reveal IL-33/ST2 signaling as a novel biomechanically-activated and cardioprotective ..
  47. Jun Li; Fiscal Year: 2016
    ..Aim 2: Test the hypothesis that PAK1 is required for the formation of tomaculum/axonal constriction. PAK1, as a serine-threonine kinase and a member of the PAK family (from PAK1 to 6), interacts with small ..
  48. Structural and mechanistic studies of mitochondrial fission
    David C Chan; Fiscal Year: 2010
    ..Dnm1, to the mitochondrial surface, where it assembles into a multimeric complex that mediates mitochondrial constriction. Dnm1 recruitment requires the mitochondrial membrane protein Fis1, with the adaptor proteins Mdv1 and Caf4 ..
  49. ROBERT D BOWLES; Fiscal Year: 2014
    ..In Aim 1, a model of chronic constriction injury (CCI) of the sciatic nerve will be developed in transgenic mice (NFkB-RE-Luc) containing a luciferase NF-..
  50. HAX-1: a Multifaceted Family of Apoptotic Regulators
    Aikaterini Kontrogianni-Konstantopoulos; Fiscal Year: 2012
    ..may restore cardiac morphology and function in rats subjected to pressure overload through transverse aortic constriction (Aim 2)...
  51. The role of interleukin-18 in myocardial hypertrophy and failure
    Bysani Chandrasekar; Fiscal Year: 2013
    ..Our studies in wild-type mice show that pressure overload induced by transverse aortic constriction (TAC) leads to left ventricular hypertrophy (LVH) and increased IL-18 expression...
  52. Steven S An; Fiscal Year: 2015
    ..Here we focus on the structure and function of airway smooth muscle - the end organ that leads to airway constriction - and the role for a transcription factor (Nrf2) in the context of airway wall remodeling in chronic asthma.
  53. Patrick J Pagano; Fiscal Year: 2016
    ..and SIRP-[unreadable]-dependent signaling, leading to marked impairment in vascular relaxation and/or enhanced constriction in I/R...
  54. MICHAEL SETH KAPILOFF; Fiscal Year: 2014
    ..and both unstressed, aging mice and mice subjected to chronic isoproterenol infusion, transverse aortic constriction and myocardial infarction will be studied. Specific Aim 2: Regulation of AC5 by mAKAPb Complexes...
  55. Kwoon Y Wong; Fiscal Year: 2016
    ..by applicant): The retina mediates various subconscious, photoadaptive responses to light, including pupil constriction, acute enhancement of alertness, regulating hormone secretion from the brain, and synchronizing the body clock ..
  56. Stephen L Archer; Fiscal Year: 2015
    ..5. At birth, O2-induced increases in mitochondrial H2O2 in DA smooth muscle cells (DASMC) promote constriction by several mechanisms: Kv channel inhibition, direct activation of O2-sensitive calcium channels and rho kinase ..
  57. Deborah J Andrew; Fiscal Year: 2015
    ..The goals of this proposal are (Aim 1) to characterize the molecular machinery that coordinates apical constriction, a cell shape change required for the formation of many organs;(Aim 2) to identify other key regulators that ..
  58. Yingjie Chen; Fiscal Year: 2014
    ..We examined the effect of double gene knockout (DKO) of BP1 and BP2 on transverse aortic constriction (TAC) or myocardial infarct induced CHF in mice, and the results demonstrated that BP1/2 DKO profoundly ..
  59. The regulatory role of Bone morphogenetic protein 1 in suture patency and fusion
    Matthew Harris; Fiscal Year: 2013
    ..Defects in suture formation lead to malformations and deformations, which cause constriction of the cranium and can impair cognition...
  60. Signaling Mechanisms in Myogenic Tone of Skeletal Muscle Arterioles: Role of BKCa
    Michael A Hill; Fiscal Year: 2012
    ..Myogenic constriction depends on smooth muscle (SM) membrane depolarization and voltage- dependent Ca2+-influx...
  61. Withrow Gil Wier; Fiscal Year: 2015
    ..The sympathetic nervous system and myogenic constriction are two key determinants of vascular tone in vivo, and NCX1 is proposed to be a specific molecular component in ..
  62. Mechanisms and regulation of macropinosome closure
    Joel A Swanson; Fiscal Year: 2010
    ..The successful completion of macropinocytosis always requires closure: the constriction of a region of the cell surface that transforms a cup-shaped invagination of plasma membrane into a discrete ..
  63. INHALATIONAL ANESTHETICS AND CORONARY VASOMOTION
    JOHN SILL; Fiscal Year: 1992
    ..Epicardial lesions are not static and fixed but are-capable of considerable constriction and dilatation, depending upon underlying coronary vascular tone...
  64. INHIBITORY LEFT ATRIAL INFLUENCES ON THE BAROREFLEX
    David Ramsay; Fiscal Year: 1991
    ..Differential changes in pressure will be achieved by graded constriction of cuffs placed around the thoracic portion of the inferior vena cava, pulmonary artery, ascending aorta and ..
  65. Endothelin vasoconstriction in a rat model of sleep apnea-induced hypertension.
    Nancy L Kanagy; Fiscal Year: 2010
    ..Intriguingly, augmented ET-1 constriction in IH/HC arteries appears to be mediated entirely by increases Ca2+ sensitivity while ET constriction in Sham ..
  66. Investigating the molecular and mechanical regulation of pulsed actomyosin contra
    ADAM CHRISTOPHER MARTIN; Fiscal Year: 2010
    ..Specifically, I have analyzed apical constriction, a common cell shape change that facilitates epithelial bending and tissue invagination...
  67. Cerebral artery Ca2+ signaling & subarachnoid hemorrhage
    George Wellman; Fiscal Year: 2009
    ..fundamental changes in Ca2+ signaling and voltage-dependent Ca2+ channel (VDCC) properties lead to enhanced constriction of cerebral arteries in an established rabbit SAH model...
  68. SITES OF ACTION OF INHALATIONAL ANESTHETICS ON HPV
    James Baumgardner; Fiscal Year: 2001
    ..Following oxygen sensing the hypoxic response is a triphasic sequence with a transient Phase 1 constriction, a more or less transient (depending on wall tension conditions) Phase 2 dilation and a persistent Phase 3 ..
  69. Regulation of Vascular Tone and Ca channels by Integrins
    Michael Davis; Fiscal Year: 2009
    ..mechanisms converge on vascular smooth muscle (VSM) ion channels to regulate intracellular Ca2+ and control constriction/dilation...
  70. CEREBRAL VESSEL INNERVATION IN HYPERTENSION
    Tony Lee; Fiscal Year: 2002
    ..In addition, the direct effect of ACh on cerebral vascular smooth muscle is constriction, not dilation...
  71. Sphingosine 1 Phosphate and Embolic Stroke
    Christian Waeber; Fiscal Year: 2003
    ..aim, we will use in vitro preparations to test the hypothesis that Rho kinases are required for S1P-induced constriction (Y-27632 should inhibit)...