virus inactivation

Summary

Summary: Inactivation of viruses by non-immune related techniques. They include extremes of pH, HEAT treatment, ultraviolet radiation, IONIZING RADIATION; DESICCATION; ANTISEPTICS; DISINFECTANTS; organic solvents, and DETERGENTS.

Top Publications

  1. ncbi Inactivation of West Nile virus, vaccinia virus and viral surrogates for relevant and emergent viral pathogens in plasma-derived products
    K M Remington
    Preclinical Research and Pathogen Safety, Biological Products Division, Bayer Health Care, LLC, Research Triangle Park, NC 27709, USA
    Vox Sang 87:10-8. 2004
  2. ncbi Virus inactivation by high intensity broad spectrum pulsed light
    Peter Roberts
    Bio Products Laboratory, Research and Development Department, Dagger Lane, Elstree, WD6 3BX, Herts, UK
    J Virol Methods 110:61-5. 2003
  3. ncbi Comparative efficacy of ethanol and isopropanol against feline calicivirus, a norovirus surrogate
    Yashpal S Malik
    Department of Veterinary Medicine, College of Veterinary Medicine, University of Minnesota, St Paul, 55108, USA
    Am J Infect Control 34:31-5. 2006
  4. ncbi Pathogen inactivation and removal procedures used in the production of intravenous immunoglobulins
    Christoph Kempf
    ZLB Behring AG, Wankdorfstr 10, CH 3000 Bern 22, Switzerland
    Biologicals 35:35-42. 2007
  5. ncbi Inactivation of avian influenza virus using common detergents and chemicals
    M E Lombardi
    Department of Bioresources Engineering, University of Delaware, 264 Townsend Hall, Newark, DE 19716, USA
    Avian Dis 52:118-23. 2008
  6. pmc Inactivation of murine norovirus by chemical biocides on stainless steel
    Thomas Magulski
    Mikrolab GmbH, Norderoog 2, D 28259 Bremen, Germany
    BMC Infect Dis 9:107. 2009
  7. ncbi Effect of high hydrostatic pressure processing on norovirus infectivity and genome stability in strawberry puree and mineral water
    Katarina Kovac
    InstitutoTecnológicoAgrario de Castilla y León ITACyL, Valladolid, Spain
    Int J Food Microbiol 152:35-9. 2012
  8. ncbi Comparative efficacy of seven hand sanitizers against murine norovirus, feline calicivirus, and GII.4 norovirus
    Geun woo Park
    Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Food Prot 73:2232-8. 2010
  9. ncbi Methylene blue photoinactivation of RNA viruses
    Robert A Floyd
    Oklahoma Medical Research Foundation, Auburn University, Auburn, AL 36849, USA
    Antiviral Res 61:141-51. 2004
  10. ncbi Heat inactivation of avian influenza and Newcastle disease viruses in egg products
    David E Swayne
    Southeast Poultry Research Laboratory, Agricultural Research Service, United States Department of Agriculture, Athens, GA 30605, USA
    Avian Pathol 33:512-8. 2004

Detail Information

Publications235 found, 100 shown here

  1. ncbi Inactivation of West Nile virus, vaccinia virus and viral surrogates for relevant and emergent viral pathogens in plasma-derived products
    K M Remington
    Preclinical Research and Pathogen Safety, Biological Products Division, Bayer Health Care, LLC, Research Triangle Park, NC 27709, USA
    Vox Sang 87:10-8. 2004
    ..The purpose of this study was to evaluate the efficacy of current viral inactivation methods for West Nile and vaccinia viruses and to reassess the use of model viruses to predict inactivation of similar viral pathogens...
  2. ncbi Virus inactivation by high intensity broad spectrum pulsed light
    Peter Roberts
    Bio Products Laboratory, Research and Development Department, Dagger Lane, Elstree, WD6 3BX, Herts, UK
    J Virol Methods 110:61-5. 2003
    ..However, in the presence of protein, i.e. 5% v/v foetal-calf serum (0.2% w/v protein), virus inactivation was less effective. At a dose of 2.0 J/cm2, virus inactivation was 5.0->6.4 log, however, HSV-1 (3...
  3. ncbi Comparative efficacy of ethanol and isopropanol against feline calicivirus, a norovirus surrogate
    Yashpal S Malik
    Department of Veterinary Medicine, College of Veterinary Medicine, University of Minnesota, St Paul, 55108, USA
    Am J Infect Control 34:31-5. 2006
    ..Because alcohol and alcohol-based products have been used as antiseptics and their efficacy against several enveloped viruses has been documented, we wanted to determine their efficacy against nonenveloped calicivirus...
  4. ncbi Pathogen inactivation and removal procedures used in the production of intravenous immunoglobulins
    Christoph Kempf
    ZLB Behring AG, Wankdorfstr 10, CH 3000 Bern 22, Switzerland
    Biologicals 35:35-42. 2007
    ..Based on their mechanism these procedures are grouped into three classes: partitioning, inactivation, and virusfiltration...
  5. ncbi Inactivation of avian influenza virus using common detergents and chemicals
    M E Lombardi
    Department of Bioresources Engineering, University of Delaware, 264 Townsend Hall, Newark, DE 19716, USA
    Avian Dis 52:118-23. 2008
    ..Only citric acid and commercially available iodine/acid disinfectant were found to be effective at inactivating LPAIV on both porous and nonporous surfaces...
  6. pmc Inactivation of murine norovirus by chemical biocides on stainless steel
    Thomas Magulski
    Mikrolab GmbH, Norderoog 2, D 28259 Bremen, Germany
    BMC Infect Dis 9:107. 2009
    ..Murine norovirus (MNV) as a surrogate for human NoV was used to study the efficacy of active ingredients of chemical disinfectants for virus inactivation on inanimate surfaces.
  7. ncbi Effect of high hydrostatic pressure processing on norovirus infectivity and genome stability in strawberry puree and mineral water
    Katarina Kovac
    InstitutoTecnológicoAgrario de Castilla y León ITACyL, Valladolid, Spain
    Int J Food Microbiol 152:35-9. 2012
    ..Finally, we found no consistent correlation between RT-qPCR and virus infectivity results, and consequently RT-qPCR is not a satisfactory tool for predicting risks to human health...
  8. ncbi Comparative efficacy of seven hand sanitizers against murine norovirus, feline calicivirus, and GII.4 norovirus
    Geun woo Park
    Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Food Prot 73:2232-8. 2010
    ..2 log units after exposure for 5 min. The susceptibility of FCV to low pH and the relative high susceptibility of MNV to alcohols suggest that both surrogate viruses should be considered for in vitro testing of hand sanitizers...
  9. ncbi Methylene blue photoinactivation of RNA viruses
    Robert A Floyd
    Oklahoma Medical Research Foundation, Auburn University, Auburn, AL 36849, USA
    Antiviral Res 61:141-51. 2004
    ..MB photoinactivation of viruses show significant promise because the technology not only offers significant potency but the history of safe MB use in human therapy makes it attractive also...
  10. ncbi Heat inactivation of avian influenza and Newcastle disease viruses in egg products
    David E Swayne
    Southeast Poultry Research Laboratory, Agricultural Research Service, United States Department of Agriculture, Athens, GA 30605, USA
    Avian Pathol 33:512-8. 2004
    ..By contrast, the HPAI virus was inactivated in liquid egg products but not in dried egg whites when using the low-temperature industry pasteurization protocol...
  11. pmc Reactions of beta-propiolactone with nucleobase analogues, nucleosides, and peptides: implications for the inactivation of viruses
    Joost P Uittenbogaard
    Unit Vaccinology, National Institute for Public Health and the Environment, 3720 BA Bilthoven, The Netherlands
    J Biol Chem 286:36198-214. 2011
    ..The study provides detailed knowledge on the chemistry of β-propiolactone inactivation of viruses...
  12. ncbi Methylene blue-mediated photodynamic inactivation as a novel disinfectant of enterovirus 71
    Tak Wah Wong
    Department of Dermatology, Graduated Institute of Clinical Medicine, National Cheng Kung University Medical College and Hospital, Tainan, Taiwan, Republic of China
    J Antimicrob Chemother 65:2176-82. 2010
    ..We tested whether methylene blue, an inexpensive and safe photosensitizer, is feasible for photodynamic inactivation of enterovirus 71 (EV71) in the environment...
  13. ncbi Production of monoclonal antibodies and development of an antigen capture ELISA directed against the envelope glycoprotein GP of Ebola virus
    Andreas Lucht
    Bundeswehr Institute of Microbiology, Neuherbergstrasse 11, 80937 Munich, Germany
    Med Microbiol Immunol 193:181-7. 2004
    ..Since the ELISA is able to detect even SDS-inactivated EBOV in spiked human sera, it could complement the existing diagnostic tools in the field and in routine laboratories where high containment facilities are not available...
  14. pmc Influenza virus inactivation for studies of antigenicity and phenotypic neuraminidase inhibitor resistance profiling
    Marcel Jonges
    National Institute for Public Health and the Environment, Center for Infectious Disease Control, Laboratory for Infectious Diseases and Screening, Bilthoven, Netherlands
    J Clin Microbiol 48:928-40. 2010
    ..Triton X-100 treatment proved to be the easiest-to-use influenza virus inactivation protocol for application in combination with phenotypic NA inhibitor susceptibility assays, while formalin ..
  15. ncbi Selection and characterization of vaccine strain for Enterovirus 71 vaccine development
    Jui Yuan Chang
    Vaccine R and D Center, National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan Township, Miaoli County 350, Taiwan
    Vaccine 30:703-11. 2012
    ..Therefore, these results provide valuable information for cell-based EV71 vaccine development...
  16. ncbi Inactivated Sendai virus particles eradicate tumors by inducing immune responses through blocking regulatory T cells
    Masayuki Kurooka
    Division of Gene Therapy Science, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Cancer Res 67:227-36. 2007
    ..Because it can enhance antitumor immunity and simultaneously remove Treg-mediated suppression, HVJ-E shows promise as a novel therapeutic for cancer immunotherapy...
  17. ncbi Effect of inactivation method on the cross-protective immunity induced by whole 'killed' influenza A viruses and commercial vaccine preparations
    Yoichi Furuya
    Viral Immunology and Molecular Virology, The John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
    J Gen Virol 91:1450-60. 2010
    ..Finally, freeze-drying of gamma-A/PC did not affect the ability to induce cross-protective immunity...
  18. ncbi Inactivation of hepatitis A virus by heat and high hydrostatic pressure: variation among laboratory strains
    N Shimasaki
    Department of Virology II, Division of Biosafety Control and Research, National Institute of Infectious Diseases, Gakuen, Musashimurayama, Tokoyo, Japan
    Vox Sang 96:14-9. 2009
    ..Cell-adapted HAV strains are generally used to confirm virus inactivation in manufacturing blood products, but the strains may differ in their sensitivity to inactivation treatment...
  19. ncbi Inactivation of hepatitis A virus and a calicivirus by high hydrostatic pressure
    David H Kingsley
    U S Department of Agriculture, Microbial Food Safety Research Unit, W W Baker Center, Delaware State University, Dover 19901, USA
    J Food Prot 65:1605-9. 2002
    Potential application of high hydrostatic pressure processing (HPP) as a method for virus inactivation was evaluated...
  20. ncbi Inactivation of hepatitis A virus by high-pressure processing: the role of temperature and pressure oscillation
    David H Kingsley
    U S Department of Agriculture, Agricultural Research Service, Microbial Food Safety Research Unit, James W W Baker Center, Delaware State University, Dover, Delaware 19901, USA
    J Food Prot 69:2454-9. 2006
    ..This work suggested that slightly elevated temperatures are advantageous for pressure inactivation of HAV within foods...
  21. ncbi Mechanism of inactivation of murine norovirus-1 by high pressure processing
    Qingjuan Tang
    College of Food Science and Engineering, Ocean University of China, No 5, Yushan Road, Qingdao, Shandong Province 266003, PR China
    Int J Food Microbiol 137:186-9. 2010
    ..The integrity of the capsid was not affect by HPP. Partial motif changes of the viral capsid caused by HPP were accessed by induced sensitivity to proteinase K...
  22. ncbi The inactivation of avian influenza virus subtype H5N1 isolated from chickens in Thailand by chemical and physical treatments
    Suwarak Wanaratana
    Department of Veterinary Medicine, Faculty of Veterinary Science, Chulalongkorn University, 39 Henri Dunant Rd, Patumwan, Bangkok 10330, Thailand
    Vet Microbiol 140:43-8. 2010
    ..In this study, CUK-2/04 was more resistant to the disinfectants, temperatures, and pH compared to the other isolates...
  23. ncbi Resistance of porcine circovirus and chicken anemia virus to virus inactivation procedures used for blood products
    Jon Welch
    Virus Evolution Group, Center for Infectious Diseases, University of Edinburgh, Summerhall, Edinburgh, UK
    Transfusion 46:1951-8. 2006
    b>Virus inactivation procedures are used to prevent contamination of plasma-derived blood products with viruses...
  24. ncbi Inactivation of influenza A virus H1N1 by disinfection process
    Eun Kyo Jeong
    Department of Biological Sciences, Hannam University, Daejeon, South Korea
    Am J Infect Control 38:354-60. 2010
    ..This study was conducted to evaluate the efficacy of disinfection processes, which can be easily operated at hospitals, in inactivating influenza A virus H1N1 (H1N1)...
  25. ncbi Inactivated Sendai virus suppresses murine melanoma growth by inducing host immune responses and down-regulating β-catenin expression
    Quan Zhang
    College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, China
    Biomed Environ Sci 25:509-16. 2012
    ..This paper aims to investigate the anti-tumor mechanism of inactivated Sendai virus (Hemagglutinating virus of Japan envelope, HVJ-E) for murine melanoma (B16F10)...
  26. ncbi Sterile alpha motif containing domain 9 is involved in death signaling of malignant glioma treated with inactivated Sendai virus particle (HVJ-E) or type I interferon
    Masahiko Tanaka
    Division of Gene Therapy Science, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    Int J Cancer 126:1982-91. 2010
    ..However, overexpression of the SAMD9 gene failed to induce significant cell death in U251MG cells. Thus, SAMD9 could be a key molecule to control cancer cell death by HVJ-E or IFN-beta treatment...
  27. ncbi Effective hepatitis A virus inactivation during low-heat dehydration of contaminated green onions
    David T Laird
    US Food and Drug Administration, National Center for Food Safety and Technology, 6502 S Archer Road, Summit Argo, IL 60501, USA
    Food Microbiol 28:998-1002. 2011
    ..4 °C reduced infectious HAV in onions by 1, 2, and 3 logs respectively, the Z value being 7.3 °C. It was concluded that low heat dehydration using 62.5 °C or above could effectively inactivate HAV on contaminated onions by >3 logs...
  28. ncbi Comparison of the efficiency and the specificity of DNA-bound and free cationic porphyrin in photodynamic virus inactivation
    Kristóf Zupán
    Institute of Biophysics and Radiation Biology, Semmelweis University, Budapest, Hungary
    J Photochem Photobiol B 90:105-12. 2008
    ..Here we tested the virus inactivation capability of meso-Tetrakis(4-N-methylpyridyl)porphyrin (TMPyP) and meso-Tri-(4-N-methylpyridyl)..
  29. pmc Inactivation of a human norovirus surrogate, human norovirus virus-like particles, and vesicular stomatitis virus by gamma irradiation
    Kurtis Feng
    Department of Food Science and Technology, College of Food, Agricultural, and Environmental Sciences, Division of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, OH, USA
    Appl Environ Microbiol 77:3507-17. 2011
    ..gamma irradiation disrupted virion structure and degraded viral proteins and genomic RNA, which resulted in virus inactivation. Using human norovirus VLPs as a model, we provide the first evidence that the capsid of human norovirus has ..
  30. ncbi Investigation of the antiviral properties of copper iodide nanoparticles against feline calicivirus
    Nozomi Shionoiri
    Division of Biotechnology and Life Science, Institute of Engineering, Tokyo University of Agriculture and Technology, 2 24 16 Naka cho, Koganei, Tokyo 184 8588, Japan
    J Biosci Bioeng 113:580-6. 2012
    ..CuI nanoparticles could be proposed as useful sources of a continuous supply of Cu(+) ions for efficient virus inactivation. Furthermore, this study brings new insights into toxic actions of copper iodide nanoparticles against ..
  31. ncbi Discrimination between infectious and non-infectious human norovirus using porcine gastric mucin
    Brooke A Dancho
    Agricultural Research Service, Food Safety and Intervention Technologies Unit, U S Department of Agriculture, Delaware State University, Dover, DE 19901, USA
    Int J Food Microbiol 155:222-6. 2012
    ..In total, these results suggest the loss of NoV binding to porcine mucin as a potential means to preferentially exclude non-infectious virus particles from subsequent RT-PCR detection...
  32. ncbi Temperature and treatment time influence high hydrostatic pressure inactivation of feline calicivirus, a norovirus surrogate
    Haiqiang Chen
    Department of Animal and Food Sciences, University of Delaware, Newark, Delaware 19716 2150, USA
    J Food Prot 68:2389-94. 2005
    ..human noroviruses, was used for detailed evaluation of the high pressure processing parameters necessary for virus inactivation. Pressure inactivation curves of FCV strain KCD in Dulbecco's modified Eagle medium with 10% fetal bovine ..
  33. ncbi Dengue virus inactivation by minipool TnBP/Triton X-45 treatment of plasma and cryoprecipitate
    T Burnouf
    Human Protein Process Sciences, Lille, France
    Vox Sang 104:1-6. 2013
    ..The goal of this study was to determine the rate and extent of inactivation of dengue virus (DENV) during this process...
  34. ncbi Pressure inactivation of hepatitis A virus in strawberry puree and sliced green onions
    David H Kingsley
    U S Department of Agriculture, Agricultural Research Service, Microbial Food Safety Research Unit, James W W Baker Center, Delaware State University, Dover, Delaware 19901, USA
    J Food Prot 68:1748-51. 2005
    ..Although high-pressure processing may cause some organoleptic alterations to strawberries and onions, results show high-pressure processing will inactivate hepatitis A virus in these foods...
  35. ncbi Inactivation of human and murine norovirus by high-pressure processing
    Gloria Sanchez
    Department of Biotechnology, Institute of Agrochemistry and Food Technology IATA, Spanish Council for Scientific Research CSIC, Paterna, Spain
    Foodborne Pathog Dis 8:249-53. 2011
    ..5 log(10) units as determined by RT-qPCR. Additionally, RNA of human NoV was more resistant to certain HPP treatments than the RNA of MNV...
  36. ncbi Response of four types of coliphages to high hydrostatic pressure
    D Guan
    Department of Animal and Food Sciences, University of Delaware, Newark, 19716 2150, USA
    Food Microbiol 23:546-51. 2006
    ..5-log(10) when exposed to 400 MPa for 5 min. Treatment at 450 MPa for 5 min was necessary to obtain a log(10) reduction of 6-7 for T4...
  37. ncbi Aqueous matrix compositions and pH influence feline calicivirus inactivation by high pressure processing
    David H Kingsley
    U S Department of Agriculture, Agricultural Research Service, Microbial Food Safety Research Unit, W W Baker Center, Delaware State University, Dover, Delaware 19901, USA
    J Food Prot 71:1598-603. 2008
    ..Aqueous matrix compositions, in particular different concentrations of NaCl and sucrose or different pH values, can substantially alter the efficiency of virus inactivation by high pressure processing.
  38. ncbi High hydrostatic pressure processing of murine norovirus 1-contaminated oysters inhibits oral infection in STAT-1(-/-)-deficient female mice
    R M Gogal
    Center for Molecular Medicine and Infectious Disease, Department of Biomedical Sciences and Pathobiology, Virginia Maryland Regional College of Veterinary Medicine, Virginia Polytechnic and State University, Blacksburg, Virginia 24061, USA
    J Food Prot 74:209-14. 2011
    ..Further, the data suggest that HPP may be an effective food processing intervention for norovirus-contaminated shellfish and thus may decrease risk to both immunocompromised and immunocompetent individuals who consume shellfish...
  39. ncbi Inactivation of selected picornaviruses by high hydrostatic pressure
    David H Kingsley
    Microbial Food Safety Research Unit, U S Department of Agriculture, Agricultural Research Service, James W W Baker Center, Delaware State University, Dover, DE 19901, USA
    Virus Res 102:221-4. 2004
    ..These data establish that different picornaviruses have widely variable pressure inactivation thresholds in response to HPP...
  40. ncbi Effect of high hydrostatic pressure on four genotypes of F-specific RNA bacteriophages
    D Guan
    Department of Animal and Food Sciences, University of Delaware, Newark, DE 19716, USA
    J Appl Microbiol 102:51-6. 2007
    ..The pressure responses of four genotypes of F-specific RNA bacteriophages, f2, GA, Qbeta and SP, were evaluated with respect to pressure magnitude, treatment temperature and suspending medium...
  41. pmc Inactivation of enteric viruses in minimally processed berries and herbs
    S Butot
    Quality and Safety Assurance Department, Nestle Research Center, Lausanne, Switzerland
    Appl Environ Microbiol 75:4155-61. 2009
    ..Addition of a terminal dry heat treatment at 120 degrees C after freeze-drying enhanced virus inactivation by at least 2 log(10) units, except for HuNoV GII...
  42. ncbi Critical studies on binding-based RT-PCR detection of infectious Noroviruses
    Dan Li
    Laboratory of Food Microbiology and Food Preservation, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    J Virol Methods 177:153-9. 2011
    ..This study indicates an improvement in the evaluation of the infectivity of non-cultivable human NoVs. This is also a comprehensive study on both specific and non-specific binding properties of NoVs...
  43. ncbi In-vivo efficacy of hand sanitisers against feline calicivirus: a surrogate for norovirus
    S L S Lages
    Department of Veterinary Population Medicine, University of Minnesota, St Paul, MN 55108, USA
    J Hosp Infect 68:159-63. 2008
    ..Further research on alternative hand sanitisers should continue for effective control of norovirus infections...
  44. ncbi Inactivation of Norovirus by ozone gas in conditions relevant to healthcare
    J B Hudson
    Viroforce Systems Inc Laboratory, Vancouver, Canada
    J Hosp Infect 66:40-5. 2007
    ..Our results show that Norovirus can be inactivated by exposure to ozone gas from a portable commercial generator in settings such as hotel rooms, cruise ship cabins and healthcare facilities...
  45. ncbi Survival and transfer of murine norovirus 1, a surrogate for human noroviruses, during the production process of deep-frozen onions and spinach
    Leen Baert
    Department of Food Safety and Food Quality, Laboratory of Food Microbiology and Food Preservation, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, 9000 Ghent, Belgium
    J Food Prot 71:1590-7. 2008
    ..Blanching spinach (80 degrees C for 1 min) resulted in at least 2.44-log reductions of infectious MNV-1, but many genomic copies were still present...
  46. ncbi Safety and protective efficacy of INA-inactivated Venezuelan equine encephalitis virus: implication in vaccine development
    Anuj Sharma
    Centre for Combat Casualty and Life Sustainment Research, Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Vaccine 29:953-9. 2011
    ..Results suggest that inactivation of enveloped viruses by INA may occur by two independent mechanisms and the INA-inactivated VEEV elicit a protective antibody response in mice...
  47. ncbi [Effects of hand hygiene on feline calicivirus inactivation and removal as norovirus surrogate treated with antiseptic hand rubbing, wet wipes, and functional water]
    Kohji Mori
    Department of Microbiology, Tokyo Metropolitan Institute of Public Health
    Kansenshogaku Zasshi 81:249-55. 2007
    ..Results underscore the importance of selection in hand washing metheds (alternative soap and also) in preventing viral gastroenteritis...
  48. ncbi The reduction of murine norovirus 1, B. fragilis HSP40 infecting phage B40-8 and E. coli after a mild thermal pasteurization process of raspberry puree
    L Baert
    Laboratory of Food Microbiology and Food Preservation, Department of Food Safety and Food Quality, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, 9000 Ghent, Belgium
    Food Microbiol 25:871-4. 2008
    ..Moreover, <3 log reductions of MNV-1 were observed suggesting that upon high initial contamination load, infectious NoV particles may remain on mildly pasteurized raspberry puree...
  49. ncbi Development of a high pressure processing inactivation model for hepatitis A virus
    Stephen F Grove
    Food Safety Centre, Tasmanian Institute of Agricultural Research, School of Agricultural Science, University of Tasmania, Private Bag 54, Hobart, Tasmania 7001, Australia
    J Food Prot 72:1434-42. 2009
    ..Additional inactivation data with greater reproducibility should be collected to enable expansion of the model and to increase the accuracy of its predictions...
  50. pmc Characterization of ozone disinfection of murine norovirus
    Mi Young Lim
    Department of Environmental Health, School of Public Health, Seoul National University, Seoul, South Korea
    Appl Environ Microbiol 76:1120-4. 2010
    ..Our results indicate that NoV may be more resistant to ozone than has been previously reported. Nevertheless, proper ozone disinfection practices can be used to easily control its transmission in water...
  51. pmc In vivo comparison of two human norovirus surrogates for testing ethanol-based handrubs: the mouse chasing the cat!
    Syed A Sattar
    Center for Research on Environmental Microbiology CREM, University of Ottawa, Ottawa, Ontario, Canada
    PLoS ONE 6:e17340. 2011
    ..These findings indicate the need for a review of the continuing use of FCV as a surrogate for HuNoV...
  52. ncbi Heat inactivation of hepatitis A virus and a norovirus surrogate in soft-shell clams (Mya arenaria)
    Halimatou Sow
    Institut des Nutraceutiques et des Aliments Fonctionnels, Universite Laval, Quebec, Quebec, Canada
    Foodborne Pathog Dis 8:387-93. 2011
    ..The results of the present study should contribute to the development of strategies for controlling the spread of enteric viral illness via shellfish...
  53. ncbi Virus inactivation by silver doped titanium dioxide nanoparticles for drinking water treatment
    Michael V Liga
    Department of Civil and Environmental Engineering, Rice University, Houston, TX 77005, USA
    Water Res 45:535-44. 2011
    ..The increased production of hydroxyl free radicals was found to be responsible for the enhanced viral inactivation...
  54. ncbi In vitro inactivation of feline calicivirus (FCV) by chemical disinfectants: resistance variation among field strains
    Barbara Di Martino
    Department of Scienze Biomediche Comparate, University of Teramo, Piazza Aldo Moro, 45, 64100 Teramo, Italy
    Arch Virol 155:2047-51. 2010
    ....
  55. pmc Effects of UVA irradiation, aryl azides, and reactive oxygen species on the orthogonal inactivation of the human immunodeficiency virus (HIV-1)
    Julie M Belanger
    Center for Cancer Research Nanobiology Program, National Cancer Institute Frederick, Frederick, MD 21702, USA
    Virology 417:221-8. 2011
    ..show detergent resistance and that this property may be useful towards the creation of a novel orthogonal virus inactivation strategy for use in preparing experimental vaccines...
  56. pmc Evaluation of liquid- and fog-based application of Sterilox hypochlorous acid solution for surface inactivation of human norovirus
    Geun woo Park
    Department of Environmental Sciences and Engineering, Univerisity of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Appl Environ Microbiol 73:4463-8. 2007
    ..9% (3 log10), regardless of carrier location and orientation. We conclude that HOCl solution as a liquid or fog is likely to be effective in disinfecting common settings to reduce NV exposures and thereby control virus spread via fomites...
  57. pmc Cholesterol depletion of human immunodeficiency virus type 1 and simian immunodeficiency virus with beta-cyclodextrin inactivates and permeabilizes the virions: evidence for virion-associated lipid rafts
    David R M Graham
    The Leukocyte Immunochemistry Laboratory, Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Virol 77:8237-48. 2003
    ....
  58. pmc High-pressure inactivation of hepatitis A virus within oysters
    Kevin R Calci
    Gulf Coast Seafood Laboratory, U S Food and Drug Administration, Dauphin Island, Alabama, USA
    Appl Environ Microbiol 71:339-43. 2005
    ..Bioconcentration of nearly 6 log(10) PFU of HAV per oyster was achieved under simulated natural conditions. These results suggest that HHP treatment of raw shellfish will be a viable strategy for the reduction of infectious HAV...
  59. ncbi Inactivation of feline calicivirus, a norovirus surrogate, by chlorine dioxide gas
    Hirofumi Morino
    Taiko Pharmaceutical Co, Ltd, Uchihonmachi 3 34 14, Suita, Osaka 564 0032, Japan
    Biocontrol Sci 14:147-53. 2009
    ..3 ppm concentration of ClO2 gas and a humidifier in places without human activity may make it possible to inactivate NV in the dry state on any surface within a contaminated room without serious adverse effects...
  60. pmc Inactivation of influenza A virus on copper versus stainless steel surfaces
    J O Noyce
    Environmental Healthcare Unit, University of Southampton, Biomedical Sciences Building, Bassett Crescent East, Southampton, UK
    Appl Environ Microbiol 73:2748-50. 2007
    ..After incubation for 24 h on stainless steel, 500,000 virus particles were still infectious. After incubation for 6 h on copper, only 500 particles were active...
  61. pmc Use of murine norovirus as a surrogate to evaluate resistance of human norovirus to disinfectants
    Gaël Belliot
    Laboratoire de Virologie, Centre National de Référence des Virus Entériques, Centre Hospitalier Universitaire de Dijon, 7 Boulevard Jeanne d Arc, 21079 Dijon Cedex, France
    Appl Environ Microbiol 74:3315-8. 2008
    ..Real-time reverse transcription-PCR results indicated that the presence of viral RNA did not correlate with the presence of infectious virus...
  62. ncbi Effects of electrolytes on virus inactivation by acidic solutions
    Mitsunori Nishide
    Division of Virology, Department of Cellular and Molecular Medicine, Wakayama Medical University Graduate School of Medicine, Wakayama, Japan
    Int J Mol Med 27:803-9. 2011
    ..We have previously shown that arginine synergizes with low pH in enhancing virus inactivation. Considering a potential application of the acid inactivation of viruses for the prevention and treatment of ..
  63. pmc Capsid functions of inactivated human picornaviruses and feline calicivirus
    Suphachai Nuanualsuwan
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, California 95616 8743, USA
    Appl Environ Microbiol 69:350-7. 2003
    ..was universal, regardless of virus type and inactivation method, except for UV-inactivated HAV, and so virus inactivation was almost always accompanied by the loss of virus attachment...
  64. ncbi Photoinactivation of hepatitis A virus by synthetic porphyrins
    Michael J Casteel
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina Chapel Hill, Chapel Hill, NC, USA
    Photochem Photobiol 80:294-300. 2004
    ..Disinfection by photoactivated synthetic porphyrins therefore can offer an effective and relatively safe approach to removal of nonenveloped viruses from aqueous media...
  65. pmc Inactivation of retroviruses with preservation of structural integrity by targeting the hydrophobic domain of the viral envelope
    Yossef Raviv
    Center for Cancer Research Nanobiology Program, NCI Frederick, Frederick, MD 21702, USA
    J Virol 79:12394-400. 2005
    ..Targeting the lipid domain of biological membranes with hydrophobic alkylating compounds could be used as a general approach for inactivation of enveloped viruses and other pathogenic microorganisms for vaccine application...
  66. ncbi Butyroyl-arginine as a potent virus inactivation agent
    Yukiko Katsuyama
    Division of Virology, Department of Cellular and Molecular Medicine, Wakayama Medical University Graduate School of Medicine, Wakayama 641 8509, Japan
    Int J Pharm 361:92-8. 2008
    b>Virus inactivation is a critical step in the manufacturing of recombinant therapeutic proteins, in particular antibodies, using mammalian expression systems...
  67. pmc Predictive model for inactivation of feline calicivirus, a norovirus surrogate, by heat and high hydrostatic pressure
    Roman Buckow
    Technische Universitat Berlin, Institut für Lebensmittelbiotechnologie und prozesstechnik, Königin Luise Strasse 22, D 14195 Berlin, Germany
    Appl Environ Microbiol 74:1030-8. 2008
    ..Modeling by nth-order kinetics of the virus inactivation was successful in predicting the inactivation of the infective virus particles...
  68. ncbi Solvent-induced virus inactivation by acidic arginine solution
    Kazuko Tsujimoto
    Division of Virology, Department of Cellular and Molecular Medicine, Wakayama Medical University Graduate School of Medicine, Wakayama 641 8509, Japan
    Int J Mol Med 25:433-7. 2010
    ..Low pH, detergent/solvent wash, or heating, called pasteurization, has been the main process for virus inactivation. Detergent/solvent wash is also used to treat superficial infectious diseases, including herpes simplex ..
  69. ncbi Molecular mechanism underlying B19 virus inactivation and comparison to other parvoviruses
    Bernhard Mani
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland
    Transfusion 47:1765-74. 2007
    ..The molecular mechanism governing the inactivation of B19V and the reason for its higher vulnerability remain unknown...
  70. ncbi Inactivation of the coronavirus that induces severe acute respiratory syndrome, SARS-CoV
    Miriam E R Darnell
    Center for Biologics Evaluation and Research, US Food and Drug Administration, 8800 Rockville Pike, HFM448, Bethesda, MD 20892, USA
    J Virol Methods 121:85-91. 2004
    ..We describe the kinetics of these efficient viral inactivation methods, which will allow research with SARS-CoV containing materials, that are rendered non-infectious, to be conducted at reduced safety levels...
  71. pmc Chlorine inactivation of highly pathogenic avian influenza virus (H5N1)
    Eugene W Rice
    US Environmental Protection Agency, Cincinnati, Ohio 45268, USA
    Emerg Infect Dis 13:1568-70. 2007
    ..Free chlorine concentrations typically used in drinking water treatment are sufficient to inactivate the virus by >3 orders of magnitude...
  72. pmc Low pH gel intranasal sprays inactivate influenza viruses in vitro and protect ferrets against influenza infection
    Paul Rennie
    Procter and Gamble Health Sciences Institute, Egham, Surrey, UK
    Respir Res 8:38. 2007
    ..The work described here investigated the sensitivity of influenza viruses to low pH, and the activity of low pH nasal sprays on the course of an influenza infection in the ferret model...
  73. pmc A novel, killed-virus nasal vaccinia virus vaccine
    Anna U Bielinska
    Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, Michigan 48109, USA
    Clin Vaccine Immunol 15:348-58. 2008
    ..VV/NE-based vaccines are highly immunogenic and induce protective mucosal and systemic immunity without the need for an inflammatory adjuvant or infection with live virus...
  74. ncbi Study on continuous (254 nm) and pulsed UV (266 and 355 nm) lights on BVD virus inactivation and its effects on biological properties of fetal bovine serum
    Mahmoud Karimi Azar Daryany
    Department of Microbiology, Faculty of Biological Sciences, Shahid Beheshti University, Evin, 19839 Tehran, Iran
    J Photochem Photobiol B 94:120-4. 2009
    ..5 J/cm(2) and 266 nm pulsed UV laser and was used to grow Vero cells, in comparison with a control group. The viability of cells in two groups was identical and the statistical evaluation showed no significant difference in 12 passages...
  75. ncbi Effects of several virucidal agents on inactivation of influenza, Newcastle disease, and avian infectious bronchitis viruses in the allantoic fluid of chicken eggs
    Motoharu Abe
    The Chemo Sero Therapeutic Research Institute, Kumamoto 860 8568, Japan
    Jpn J Infect Dis 60:342-6. 2007
    ..BC is easily biodegradable by activated sludge and is not very harmful to humans. We strongly recommend BC as a useful virucidal agent, especially in the manufacture of vaccines for these viruses...
  76. pmc Inactivation and purification of cowpea mosaic virus-like particles displaying peptide antigens from Bacillus anthracis
    Jamie P Phelps
    The Dow Chemical Company, Dowpharma, San Diego, CA 92121, USA
    J Virol Methods 141:146-53. 2007
    ..3 g kg(-1) of leaf tissue. The results demonstrate the ability to generate multi-gram quantities of non-infectious, chimeric CPMV VLPs in plants for use in the development of peptide-based vaccines...
  77. pmc Inactivation of a norovirus by high-pressure processing
    David H Kingsley
    US Department of Agriculture, Agricultural Research Service, Microbial Food Safety Research Unit, James W W Baker Center, Delaware State University, Dover, DE 19901 USA
    Appl Environ Microbiol 73:581-5. 2007
    ..56 log(10) PFU. Evaluation of virus inactivation as a function of treatment times ranging from 0 to 150 s and 0 to 900 s at 5 degrees C and 20 degrees C, ..
  78. ncbi Evaluation of resistance development and viability recovery by a non-enveloped virus after repeated cycles of aPDT
    Liliana Costa
    CESAM and Department of Biology, University of Aveiro, 3810 193 Aveiro, Portugal
    Antiviral Res 91:278-82. 2011
    ..The results suggest that aPDT represents a valuable and promising alternative therapy to treat viral infections, overcoming the problem of microbial resistance...
  79. pmc Modeling the airborne survival of influenza virus in a residential setting: the impacts of home humidification
    Theodore A Myatt
    Environmental Health and Engineering, Inc, Needham, MA, USA
    Environ Health 9:55. 2010
    ..Maintaining airborne moisture levels that reduce survival of the virus in the air and on surfaces could be another tool for managing public health risks of influenza...
  80. ncbi Visible light sensitized inactivation of MS-2 bacteriophage by a cationic amine-functionalized C60 derivative
    Min Cho
    Civil and Environmental Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    Environ Sci Technol 44:6685-91. 2010
    ..and 1O2 CT (the product of 1O2 concentration and exposure time) required to achieve a target level of virus inactivation was quantitatively analyzed...
  81. pmc Hydrophobic inactivation of influenza viruses confers preservation of viral structure with enhanced immunogenicity
    Yossef Raviv
    Nanobiology Program, Center of Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA
    J Virol 82:4612-9. 2008
    ..When used as a vaccine given intranasally (i.n.), INA-inactivated influenza virus induced immune responses similar to live virus infection...
  82. ncbi Inactivation of hepatitis A virus and norovirus surrogate in suspension and on food-contact surfaces using pulsed UV light (pulsed light inactivation of food-borne viruses)
    Julie Jean
    Institut des Nutraceutiques et des Aliments Fonctionnels, Universite Laval, Quebec, Quebec G1K 7P4, Canada
    Food Microbiol 28:568-72. 2011
    ..This study showed that short duration pulses represent an excellent alternative for inactivation of food-borne viruses. This technology could be used to inactivate viruses in drinking water or on food-handling surfaces...
  83. ncbi Evaluation of murine norovirus as a surrogate for human norovirus and hepatitis A virus in heat inactivation studies
    J Hewitt
    Communicable Disease Group, Institute of Environmental Science and Research Ltd, Kenepuru Science Centre, Porirua, New Zealand
    J Appl Microbiol 107:65-71. 2009
    ..To determine the suitability of murine norovirus (MNV) as a surrogate for human norovirus (HuNoV) in heat inactivation studies...
  84. pmc Inactivation and UV disinfection of murine norovirus with TiO2 under various environmental conditions
    Jungeun Lee
    Institute of Health and Environment, Department of Environmental Health, School of Public Health, Seoul National University, 28 Yeongeon dong, Chongro Gu, Seoul, Korea
    Appl Environ Microbiol 74:2111-7. 2008
    ..6-log(10) reductions in the amounts of infectious MNV occurred with and without TiO(2), respectively. Our results demonstrate that MNV can persist in various environmental conditions and can be efficiently controlled by UV disinfection...
  85. ncbi Complete inactivation of Venezuelan equine encephalitis virus by 1,5-iodonaphthylazide
    Anuj Sharma
    Centre for Combat Casualty and Life Sustainment Research, Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Biochem Biophys Res Commun 358:392-8. 2007
    ..This data suggest that such inactivation strategies can be used for developing vaccine candidates for VEEV and other enveloped viruses...
  86. ncbi Inactivation of SARS coronavirus by means of povidone-iodine, physical conditions and chemical reagents
    Hiroaki Kariwa
    Laboratory of Public Health, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Dermatology 212:119-23. 2006
    ..Irradiation with ultraviolet light at 134 microW/cm(2) for 15 min reduced the infectivity from 3.8 x 10(7) to 180 TCID(50)/ml; however, prolonged irradiation (60 min) failed to eliminate the remaining virus, leaving 18.8 TCID(50)/ml...
  87. ncbi Improvement of virus safety of an antihemophilc factor IX by virus filtration process
    In Seop Kim
    Department of Biological Sciences, College of Life Science and Nanotechnology, Hannam University, Daejon, Korea
    J Microbiol Biotechnol 18:1317-25. 2008
    ..12 for HAV, >or=4.28 for PPV, >or=5.33 for EMCV, >or=5.51 for HIV, >or=5.17 for BVDV, and >or=5.75 for BHV. These results indicate that the virus filtration process successfully improved the viral safety of factor IX...
  88. ncbi Physicochemical characterization of El Tor Vibriophage S20
    Moumita Dutta
    Division of Electron Microscopy, National Institute of Cholera and Enteric Diseases, Kolkata, India
    Intervirology 50:264-72. 2007
    ..To characterize Vibrio cholerae El Tor typing phage S20 (ATCC No. 51352-B3)...
  89. ncbi Photochemical treatment of plasma with amotosalen and long-wavelength ultraviolet light inactivates pathogens while retaining coagulation function
    Yasmin Singh
    Cerus Corp, Concord, California 94520, USA
    Transfusion 46:1168-77. 2006
    ..These studies evaluated the efficacy of PCT to inactivate pathogens in plasma and the effect of PCT on plasma function...
  90. ncbi Assessment of viral inactivation during pH 3.3 pepsin digestion and caprylic acid treatment of antivenoms
    Thierry Burnouf
    Human Plasma Product Services, 18 rue Saint Jacques, F 59000 Lille, France
    Biologicals 35:329-34. 2007
    ..Therefore the current manufacturing processes of at least some animal antisera already include production steps that can ensure robust viral inactivation of LE viruses and moderate inactivation of a NLE virus...
  91. ncbi Avian reovirus activates a novel proapoptotic signal by linking Src to p53
    Lin Ping-Yuan
    Graduate Institute and Department of Life Science, Tzu Chi University, 701, Sec 3, Chung Yang Rd, Hualien, Taiwan, 970
    Apoptosis 11:2179-93. 2006
    ..These studies provide strong evidence that the viral gene expression is required for ARV S1133 to initiate a proapoptotic signal via Src to p53. In addition, sigmaC was able to utilize a p53-dependent pathway to elicit apoptosis...
  92. pmc Infectivity of RNA from inactivated poliovirus
    Suphachai Nuanualsuwan
    World Health Organization Collaborating Center for Food Virology, Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616 8743, USA
    Appl Environ Microbiol 69:1629-32. 2003
    ..The results of these experiments indicate that viral RNA is a primary target of UV and hypochlorite inactivations but that the sole target of thermal inactivation is the viral capsid...
  93. ncbi Inactivation of lipid enveloped viruses by octanoic Acid treatment of immunoglobulin solution
    H Dichtelmüller
    Biotest Pharma GmbH, Dreieich, Germany
    Biologicals 30:135-42. 2002
    ..Octanoic acid treatment as described here, has been demonstrated as an effective and rapid virus inactivation procedure, which shows high robustness at the tested ranges of temperature, pH and protein content of the ..
  94. ncbi Characterization of Vibrio cholerae O1 ElTor typing phage S5
    K Mitra
    Division of Electron Microscopy, National Institute of Cholera and Enteric Diseases, Kolkata, India
    Arch Virol 152:1775-86. 2007
    ..SDS-PAGE of phage S5 shows two major structural polypeptides of 50 and 42 kDa. A 3D structure of the phage head was reconstructed at a resolution of 37 A using Cryo-EM and a single-particle reconstruction technique...
  95. ncbi Dry-heat treatment process for enhancing viral safety of an antihemophilic factor VIII concentrate prepared from human plasma
    In Seop Kim
    Department of Biological Sciences, College of Life Science and Nanotechnology, Hannam University, Daejon 305 811, Korea
    J Microbiol Biotechnol 18:997-1003. 2008
    ..Moreover, the treatment represents an effective measure for the inactivation of non-lipid-enveloped viruses, in particular HAV, which is resistant to solvent/detergent treatment...
  96. ncbi Inactivation of Hantaan virus-containing samples for subsequent investigations outside biosafety level 3 facilities
    Annette A Kraus
    Institut fur Virologie, Charite, Universitatsmedizin Berlin, Campus Charite Mitte, Berlin, Germany
    Intervirology 48:255-61. 2005
    ..A biosafety program must address handling and disposal of infectious materials as well as appropriate virus inactivation or depletion procedures to permit necessary further processing of specimens outside the biosafety level 3 ..
  97. ncbi H5N1 influenza virus and the safety of plasma products
    T R Kreil
    Global Pathogen Safety and R and D Vaccines, Baxter BioScience, Vienna, Austria
    Transfusion 47:452-9. 2007
    ..To confirm the safety margins of plasma products, dedicated virus inactivation processes used during their production were investigated for their effectiveness in inactivating this virus ..
  98. pmc Effect of exposure to UV-C irradiation and monochloramine on adenovirus serotype 2 early protein expression and DNA replication
    Kwanrawee Sirikanchana
    Department of Civil and Environmental Engineering, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Appl Environ Microbiol 74:3774-82. 2008
    ..Future efforts will determine the pre-E1A synthesis step in the adenovirus life cycle affected by exposure to UV and monochloramine, with the goal of identifying the viral molecular target of these two disinfectants...
  99. ncbi Photochemical inactivation of selected viruses and bacteria in platelet concentrates using riboflavin and light
    Patrick H Ruane
    Navigant Biotechnologies, Lakewood, Colorado 80215, USA
    Transfusion 44:877-85. 2004
    ..A medical device is being developed for the reduction of pathogens in PLT concentrates (PCs). The device uses broadband UV light and the compound riboflavin (vitamin B(2))...
  100. ncbi Inactivation of SARS coronavirus by means of povidone-iodine, physical conditions, and chemical reagents
    Hiroaki Kariwa
    Laboratory of Public Health, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Jpn J Vet Res 52:105-12. 2004
    ..8 TCID50/ml. We believe that these findings will be useful for the implementation of infection control measures against SARS, and for the establishment of effective guidelines for the prevention of SARS outbreaks...
  101. ncbi Isolation of Nanjing local strains of HHV-7 and their biological and immunological characteristics
    Kun Yao
    Department of Microbiology and Immunology, Nanjing Medical University, Nanjing 210029, China
    Cell Mol Immunol 1:367-72. 2004
    ..Infection with HHV-7 in vitro could affect immune function of lymphocytes by disturbing cytokine production and CD antigen expression...

Research Grants37

  1. CRYOBARIC INACTIVATION OF VIRAL CONTAMINANTS IN PLASMA
    NATHAN LAWRENCE; Fiscal Year: 2002
    ..PCT achieves virus inactivation through application of repeated pulses of hyperbaric pressure to plasma or protein solutions...
  2. Neutralizing antibodies raised by covalent immunization
    Yasuhiro Nishiyama; Fiscal Year: 2007
    ..The studies are likely to strengthen the foundation for further development of neutralizing antibodies capable of permanent virus inactivation. [unreadable] [unreadable]
  3. CFI Pathogen Inactivation Technology
    Trevor P Castor; Fiscal Year: 2010
    ..We plan to develop this technology as an orthogonal virus inactivation technology to techniques such as solvent-detergent (SD) that is not effective against non-enveloped viruses ..
  4. CFI Inactivation of Human Plasma
    TREVOR CASTOR; Fiscal Year: 2009
    ..We propose to do so by further advancing a unique, rapid and generally applicable virus inactivation technique based on supercritical and near-critical fluids (SuperFluids" or SFS) technology...
  5. Development of a Novel Semen-Activated Prodrug as an Anti-HIV Microbicide
    ROBERT WALTER BUCKHEIT; Fiscal Year: 2010
    ..to mimic the events which must occur in the vagina and to quantify the kinetics of drug activation and virus inactivation in the presence of semen and other appropriate biological matrices...
  6. Functional Characterization of the Hepatitis C Virus E1-E2 Glycoproteins
    GREGORY B MELIKIAN; Fiscal Year: 2010
    ..in the absence of receptors does not induce irreversible conformational changes in E1E2 leading to virus inactivation;(2) binding to soluble or to membrane-anchored receptors renders E1E2 competent to undergo conformational ..
  7. Multivalent Env gp120 Targeting Gold Nanoparticle Virucides of HIV-1
    Irwin M Chaiken; Fiscal Year: 2013
    ..The results will provide precedent for how other gp120 inhibitor-NP compositions can be devised for HIV-1 virus inactivation as well as how ligand-specific pathogen rupture can potentially be achieved for other viruses that contain ..
  8. SUPERFLUIDS--ELECTRIC FIELD VIRUS INACTIVATION
    TREVOR CASTOR; Fiscal Year: 1999
    ..Aphios has developed a rapid and generally applicable virus inactivation technique for both enveloped and non-enveloped viruses based on supercritical and near-critical fluids (..
  9. VIRUS INACTIVATION OF HUMAN RED CELLS FOR TRANSFUSION
    CLARK EDSON; Fiscal Year: 1999
    ..safe as a result of extensive donor screening and testing, there is a still great need for safe, effective virus inactivation procedure(s)...
  10. DEVELOPMENT OF AN IMPROVED VIRUS-FREE FIBRIN GLUE
    TREVOR CASTOR; Fiscal Year: 2000
    ..glue sealant for off-the-shelf surgical applications and burn treatment by utilizing a unique and effective virus inactivation technology...
  11. VIRALLY INACTIVATED HUMAN RED CELLS FOR TRANSFUSION
    Andrei Purmal; Fiscal Year: 2004
    ..In the United States alone, there are over 12,000,000 red blood cell transfusions annually and there is no virus inactivation procedure available to decontaminate them...
  12. IN VITRO INACTIVATION OF VIRUSES IN BLOOD COMPONENTS
    Daniel Meruelo; Fiscal Year: 1999
    ..Potential methods for removal of HY from blood after virus inactivation, incorporating hydrophobic resins and other methods will be evaluated...
  13. VIRUS PHOTOINACTIVATION--DIMETHYLMETHYLENE BLUE IN RBC
    Stephen Wagner; Fiscal Year: 2004
    ..However, the development of virus inactivation methods should provide an additional level of safety...
  14. OMRF MRI SYSTEM
    ROBERT FLOYD; Fiscal Year: 2004
    ..Additionally, new MRI technology will be developed for assessing tissue localization of specific flee radicals with a focus on nitric oxide intermediates, and tissue-specific contrast enhancement. ..
  15. CVN-12p1 Chimeras and Combinations for AIDS Microbiocides
    Irwin Chaiken; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  16. Novel Approaches to the Assessment of Oral Mucosal Immu*
    Theresa Whiteside; Fiscal Year: 2003
    ..A better understanding of oral immunity in normal and HIV-infected mucosa is important for the development of new antiviral therapies, including oral antiviral vaccines. ..
  17. Evalulation of Echinacea in a Human Rhinovirus Challenge
    Ronald Turner; Fiscal Year: 2003
    ....
  18. Characterization of Human Caliciviruses
    Xi Jiang; Fiscal Year: 2010
    ..abstract_text> ..
  19. ENHANCING COLLECTIN MEDIATED HOST DEFENSE
    Kevan Hartshorn; Fiscal Year: 2001
    ..These experiments should yield important insights into basic collection biology and demonstrate that enhancement of collectin-mediated pulmonary host defense can be achieved in vivo through rational alteration of wild type collectins. ..
  20. Automated high-throughput detection anti-HLA antibodies
    John Roback; Fiscal Year: 2006
    ..This application proposes to develop a test that could be used to screen blood donors for these antibodies, thus preventing TRALI and improving patient outcomes. [unreadable] [unreadable] [unreadable]..
  21. Rapid quantitation of residual WBCs in filtered blood
    John Roback; Fiscal Year: 2004
    ....
  22. INTERLEUKIN 5 RECEPTOR RECOGNITION, MIMETICS, ANTAGONISM
    Irwin Chaiken; Fiscal Year: 2004
    ..And it will yield antagonist strategies which could lead to molecular tools for therapeutic intervention in asthma and other allergic diseases. ..
  23. Structural Mechanism of IL5-Receptor Subunit Recruitment
    Irwin Chaiken; Fiscal Year: 2004
    ....
  24. IMMUNOPATHOLOGY OF HIV-1 VPR
    Velpandi Ayyavoo; Fiscal Year: 2007
    ..abstract_text> ..
  25. El Paso Community College's Transition EARDA Activities
    Maria Alvarez; Fiscal Year: 2006
    ..S.-Mexico border region. ..
  26. NOVEL DEVICES FOR RAPID BLOOD COMPATIBILITY TESTING
    John Roback; Fiscal Year: 2004
    ..The results of the multi-center trial (to be completed during Phase Ill) will lead to an FDA 510(k) application. ..
  27. Norwalk-like Viruses and Their Receptors
    Xi Jiang; Fiscal Year: 2009
    ..Specific aim 3. To determine the crystal structure of NLV capsid and sub-capsid units in the presence and absence of human histo-blood group antigens. ..
  28. Feasibility and Pilot Efficacy of Flash-heated Breastmilk to Reduce Pediatric HIV
    Caroline Chantry; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  29. Vaccine-enhanced DLI to prevent cancer recurrence after stem cell transplantation
    John Roback; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  30. Third International Calicivirus Conference
    Xi Jiang; Fiscal Year: 2007
    ..We will publish a proceeding of the meeting as a supplement of the Journal of[unreadable] Infectious Diseases after the meeting. ..
  31. DNA-Based Vaccines for Oral Carcnoma
    Theresa Whiteside; Fiscal Year: 2005
    ....
  32. MURINE MODEL FOR MONKEY B VIRUS INFECTION
    JERRY RITCHEY; Fiscal Year: 2004
    ..abstract_text> ..
  33. FREE RADICALS AND CHOLINE DEFICIENT LIVER CARCINOGENESIS
    ROBERT FLOYD; Fiscal Year: 2005
    ..C) We will determine if PBN (or its metabolite 4-OH-PBN) inhibits CD-mediated HCC development and ascertain if these compounds increase apoptosis in preneoplastic cells in this model. ..
  34. Allogeneic BMT and adoptive antiviral immunotherapy
    John Roback; Fiscal Year: 2005
    ..Furthermore, these investigations will provide an improved understanding of the defects that render allogeneic HPCT recipients susceptible to lethal infections. ..
  35. Bioactivity and Vitamins in Flash-heated Breastmilk
    Caroline Chantry; Fiscal Year: 2005
    ..Information from these analyses will be used in linear programming to predict how the described changes in nutrient content of milk due to heating would affect the overall dietary needs of the child and the associated costs. ..