microbial sensitivity tests

Summary

Summary: Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).

Top Publications

  1. pmc Rapid molecular detection of tuberculosis and rifampin resistance
    Catharina C Boehme
    Foundation for Innovative New Diagnostics, Geneva, Switzerland
    N Engl J Med 363:1005-15. 2010
  2. ncbi Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance
    A P Magiorakos
    European Centre for Disease Prevention and Control, Stockholm, Sweden
    Clin Microbiol Infect 18:268-81. 2012
  3. pmc Epidemiology of invasive candidiasis: a persistent public health problem
    M A Pfaller
    Medical Microbiology Division, C606 GH, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Clin Microbiol Rev 20:133-63. 2007
  4. pmc Acinetobacter baumannii: emergence of a successful pathogen
    Anton Y Peleg
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center and Harvard Medical School, 110 Francis Street, LMOB Suite GB, Boston, MA 02215, USA
    Clin Microbiol Rev 21:538-82. 2008
  5. pmc Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India
    Dongeun Yong
    Yonsei University College of Medicine, Research Institute of Antimicrobial Resistance, Seoul, Republic of Korea
    Antimicrob Agents Chemother 53:5046-54. 2009
  6. pmc Antibiotics for emerging pathogens
    Michael A Fischbach
    Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Science 325:1089-93. 2009
  7. ncbi Antimicrobial effects of silver nanoparticles
    Jun Sung Kim
    Laboratory of Toxicology, Seoul National University, Seoul, Korea
    Nanomedicine 3:95-101. 2007
  8. ncbi Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances
    Irith Wiegand
    Centre for Microbial Diseases and Immunity Research, University of British Columbia, 2259 Lower Mall Research Station, Vancouver, British Columbia, V6T 1Z4, Canada
    Nat Protoc 3:163-75. 2008
  9. ncbi Determination of minimum inhibitory concentrations
    J M Andrews
    Department of Microbiology, City Hospital NHS Trust, Birmingham B18 7QH, UK
    J Antimicrob Chemother 48:5-16. 2001
  10. ncbi An increasing threat in hospitals: multidrug-resistant Acinetobacter baumannii
    Lenie Dijkshoorn
    Department of Infectious Diseases C5 P, Leiden University Medical Centre, Albinusdreef 2, P O Box 9600, 2300 RC Leiden, The Netherlands
    Nat Rev Microbiol 5:939-51. 2007

Research Grants

  1. Nitogen reduction and xenobiotic response
    Lauren A Trepanier; Fiscal Year: 2010
  2. Novel antibacterial agents for treatment of Tularemia
    Nachum Kaplan; Fiscal Year: 2004
  3. Host Cell Killing by EPEC: Central Role in Pathogenesis
    JOHN CRANE; Fiscal Year: 2005
  4. Validation of topography-biased antibody libraries
    Sylvia Smith; Fiscal Year: 2005
  5. C. Perfringens to Induce Anti-HIV Mucosal Immunity
    Phalguni Gupta; Fiscal Year: 2006
  6. Novel Inorganic Nucleases
    James Cowan; Fiscal Year: 2006
  7. Therapeutic vaccine against tuberculosis
    Lee Riley; Fiscal Year: 2006
  8. Effect of Zinc in Enteropathogenic E. coli Infection
    JOHN CRANE; Fiscal Year: 2006
  9. Plasmid-Mediated Quinolone Resistance
    George Jacoby; Fiscal Year: 2007
  10. Neonatal Immunization with Acellular Pertussis Vaccines
    Natasha Halasa; Fiscal Year: 2007

Detail Information

Publications319 found, 100 shown here

  1. pmc Rapid molecular detection of tuberculosis and rifampin resistance
    Catharina C Boehme
    Foundation for Innovative New Diagnostics, Geneva, Switzerland
    N Engl J Med 363:1005-15. 2010
    ..Early detection is essential to reduce the death rate and interrupt transmission, but the complexity and infrastructure needs of sensitive methods limit their accessibility and effect...
  2. ncbi Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance
    A P Magiorakos
    European Centre for Disease Prevention and Control, Stockholm, Sweden
    Clin Microbiol Infect 18:268-81. 2012
    ....
  3. pmc Epidemiology of invasive candidiasis: a persistent public health problem
    M A Pfaller
    Medical Microbiology Division, C606 GH, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Clin Microbiol Rev 20:133-63. 2007
    ..Further research to improve diagnostic, preventive, and therapeutic strategies is necessary to reduce the considerable morbidity and mortality associated with IC...
  4. pmc Acinetobacter baumannii: emergence of a successful pathogen
    Anton Y Peleg
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center and Harvard Medical School, 110 Francis Street, LMOB Suite GB, Boston, MA 02215, USA
    Clin Microbiol Rev 21:538-82. 2008
    ....
  5. pmc Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India
    Dongeun Yong
    Yonsei University College of Medicine, Research Institute of Antimicrobial Resistance, Seoul, Republic of Korea
    Antimicrob Agents Chemother 53:5046-54. 2009
    ..The broad resistance carried on these plasmids is a further worrying development for India, which already has high levels of antibiotic resistance...
  6. pmc Antibiotics for emerging pathogens
    Michael A Fischbach
    Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Science 325:1089-93. 2009
    ....
  7. ncbi Antimicrobial effects of silver nanoparticles
    Jun Sung Kim
    Laboratory of Toxicology, Seoul National University, Seoul, Korea
    Nanomedicine 3:95-101. 2007
    ..These results suggest that Ag nanoparticles can be used as effective growth inhibitors in various microorganisms, making them applicable to diverse medical devices and antimicrobial control systems...
  8. ncbi Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances
    Irith Wiegand
    Centre for Microbial Diseases and Immunity Research, University of British Columbia, 2259 Lower Mall Research Station, Vancouver, British Columbia, V6T 1Z4, Canada
    Nat Protoc 3:163-75. 2008
    ..Growth is assessed after incubation for a defined period of time (16-20 h) and the MIC value is read. This protocol applies only to aerobic bacteria and can be completed in 3 d...
  9. ncbi Determination of minimum inhibitory concentrations
    J M Andrews
    Department of Microbiology, City Hospital NHS Trust, Birmingham B18 7QH, UK
    J Antimicrob Chemother 48:5-16. 2001
    ..Tables giving expected MIC ranges for control NCTC and ATCC strains are also supplied...
  10. ncbi An increasing threat in hospitals: multidrug-resistant Acinetobacter baumannii
    Lenie Dijkshoorn
    Department of Infectious Diseases C5 P, Leiden University Medical Centre, Albinusdreef 2, P O Box 9600, 2300 RC Leiden, The Netherlands
    Nat Rev Microbiol 5:939-51. 2007
    ..Here, we present an overview of the current knowledge of the genus Acinetobacter, with the emphasis on the clinically most important species, Acinetobacter baumannii...
  11. pmc Sublethal antibiotic treatment leads to multidrug resistance via radical-induced mutagenesis
    Michael A Kohanski
    Howard Hughes Medical Institute, Boston University, Boston, MA 02215, USA
    Mol Cell 37:311-20. 2010
    ..This work establishes a radical-based molecular mechanism whereby sublethal levels of antibiotics can lead to multidrug resistance, which has important implications for the widespread use and misuse of antibiotics...
  12. ncbi Essential oils: their antibacterial properties and potential applications in foods--a review
    Sara Burt
    Department of Public Health and Food Safety, Faculty of Veterinary Medicine, University of Utrecht, P O Box 80175, 3508 TD Utrecht, The Netherlands
    Int J Food Microbiol 94:223-53. 2004
    ..Some EO components are legally registered flavourings in the EU and the USA. Undesirable organoleptic effects can be limited by careful selection of EOs according to the type of food...
  13. ncbi An epidemic, toxin gene-variant strain of Clostridium difficile
    L Clifford McDonald
    Epidemiology and Laboratory Branch, Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, USA
    N Engl J Med 353:2433-41. 2005
    ..difficile with increased virulence, resistance, or both...
  14. ncbi Multidrug-resistance efflux pumps - not just for resistance
    Laura J V Piddock
    Antimicrobial Agents Research Group, Division of Immunity and Infection, The Medical School, University of Birmingham, Birmingham B15 2TT, UK
    Nat Rev Microbiol 4:629-36. 2006
    ..Here, I present the accumulating evidence that multidrug-resistance efflux pumps have roles in bacterial pathogenicity and propose that these pumps therefore have greater clinical relevance than is usually attributed to them...
  15. ncbi Biological effects of essential oils--a review
    F Bakkali
    Institut Curie Section de Recherche, UMR2027 CNRS IC, LCR V28 CEA, Bat 110, Centre Universitaire, 91405 Orsay Cedex, France Université Abdelmalek Essâadi, Faculte des Sciences, Laboratoire de Biologie et Santé, BP 2121, Tetouan, Morocco
    Food Chem Toxicol 46:446-75. 2008
    ..These findings suggest that, at least in part, the encountered beneficial effects of essential oils are due to prooxidant effects on the cellular level...
  16. pmc Pulsed-field gel electrophoresis typing of oxacillin-resistant Staphylococcus aureus isolates from the United States: establishing a national database
    Linda K McDougal
    Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Clin Microbiol 41:5113-20. 2003
    ..Noticeably absent from the U.S. database were isolates with the previously described Brazilian and EMRSA15 PFGE patterns. These data suggest that there are a limited number of ORSA genotypes present in the United States...
  17. pmc Specialized persister cells and the mechanism of multidrug tolerance in Escherichia coli
    Iris Keren
    Department of Biology, Northeastern University, 134 Mugar Hall, 360 Huntington Ave, Boston, MA 02115
    J Bacteriol 186:8172-80. 2004
    ..The function of these specialized dormant cells is to ensure the survival of the population in the presence of lethal factors...
  18. pmc Extended-spectrum beta-lactamases: a clinical update
    David L Paterson
    Infectious Disease Division, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Clin Microbiol Rev 18:657-86. 2005
    ..ESBLs represent an impressive example of the ability of gram-negative bacteria to develop new antibiotic resistance mechanisms in the face of the introduction of new antimicrobial agents...
  19. ncbi A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis
    Koen Andries
    Johnson and Johnson Pharmaceutical Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium
    Science 307:223-7. 2005
    ..Plasma levels associated with efficacy in mice were well tolerated in healthy human volunteers. Mutants selected in vitro suggest that the drug targets the proton pump of adenosine triphosphate (ATP) synthase...
  20. ncbi Comparison of community- and health care-associated methicillin-resistant Staphylococcus aureus infection
    Timothy S Naimi
    Acute Disease Investigation and Control Section, Minnesota Department of Health, Minneapolis, USA
    JAMA 290:2976-84. 2003
    ..However, MRSA has emerged in patients without established risk factors (community-associated MRSA)...
  21. pmc Bacterial charity work leads to population-wide resistance
    Henry H Lee
    Howard Hughes Medical Institute, Center for BioDynamics, Boston, Massachusetts 02115, USA
    Nature 467:82-5. 2010
    ....
  22. pmc Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor
    M Zasloff
    Proc Natl Acad Sci U S A 84:5449-53. 1987
    ..The sequence of a partial cDNA of the precursor reveals that both peptides derive from a common larger protein. These peptides appear to represent a previously unrecognized class of vertebrate antimicrobial activities...
  23. ncbi Anti-infective potential of natural products: how to develop a stronger in vitro 'proof-of-concept'
    Paul Cos
    Laboratory for Microbiology, Parasitology and Hygiene LMPH, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium
    J Ethnopharmacol 106:290-302. 2006
    ....
  24. pmc Evolution of multidrug resistance during Staphylococcus aureus infection involves mutation of the essential two component regulator WalKR
    Benjamin P Howden
    Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia
    PLoS Pathog 7:e1002359. 2011
    ..aureus infections and demonstrates the role played by walKR to increase drug resistance, control metabolism and alter the virulence potential of this pathogen...
  25. ncbi Survey of infections due to Staphylococcus species: frequency of occurrence and antimicrobial susceptibility of isolates collected in the United States, Canada, Latin America, Europe, and the Western Pacific region for the SENTRY Antimicrobial Surveillanc
    D J Diekema
    Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Clin Infect Dis 32:S114-32. 2001
    ..Given the increasing multidrug resistance among staphylococci and the possible emergence of vancomycin-resistant strains, global strategies are needed to control emergence and spread of multiply resistant staphylococci...
  26. ncbi Alarming β-lactamase-mediated resistance in multidrug-resistant Enterobacteriaceae
    Karen Bush
    Biology Department, Indiana University Bloomington, Bloomington, IN 47405, USA
    Curr Opin Microbiol 13:558-64. 2010
    ..These enzymes are now appearing in multiple combinations of ESBLs and carbapenemases, thereby conferring resistance to virtually all β-lactam antibiotics...
  27. ncbi Pseudomonas biofilm formation and antibiotic resistance are linked to phenotypic variation
    Eliana Drenkard
    Department of Genetics, Harvard Medical School, Massahusetts General Hospital, Boston, MA 02114, USA
    Nature 416:740-3. 2002
    ..Compounds that affect PvrR function could have an important role in the treatment of CF infections...
  28. pmc Evaluation and strategy for use of MIRU-VNTRplus, a multifunctional database for online analysis of genotyping data and phylogenetic identification of Mycobacterium tuberculosis complex isolates
    Caroline Allix-Béguec
    Genoscreen, 1, rue du Professeur Calmette, Lille 59019 Cedex, France
    J Clin Microbiol 46:2692-9. 2008
    ..The MIRU-VNTRplus database is a powerful tool for high-resolution clonal identification and has little equivalent in terms of functionalities among the bacterial genotyping databases available so far...
  29. pmc SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of Mycobacterium tuberculosis
    Kapil Tahlan
    Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute for Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, USA
    Antimicrob Agents Chemother 56:1797-809. 2012
    ..Our results suggest that MmpL3 is the target of SQ109 and that MmpL3 is a transporter of mycobacterial TMM...
  30. ncbi Synergy, antagonism, and what the chequerboard puts between them
    F C Odds
    J Antimicrob Chemother 52:1. 2003
  31. ncbi A sensitive and quick microplate method to determine the minimal inhibitory concentration of plant extracts for bacteria
    J N Eloff
    Department of Pharmacology, University of Pretoria, South Africa
    Planta Med 64:711-3. 1998
    ..MIC values determined for sulfisoxazole, norfloxacin, gentamicin, and nitrofuratoin were similar to values indicated in the literature but values obtained with trimethroprim and ampicillin were higher with some bacteria...
  32. pmc Biofilms and planktonic cells of Pseudomonas aeruginosa have similar resistance to killing by antimicrobials
    A L Spoering
    Department of Biology, Northeastern University, 405 Mugar, 360 Huntington Ave, Boston, MS 02115, USA
    J Bacteriol 183:6746-51. 2001
    ..We further suggest that tolerance to antibiotics in stationary-phase or biofilm cultures is largely dependent on the presence of persister cells...
  33. pmc Molecular detection of mutations associated with first- and second-line drug resistance compared with conventional drug susceptibility testing of Mycobacterium tuberculosis
    Patricia J Campbell
    Mycobacteriology Laboratory Branch, Division of Tuberculosis Elimination, National Center for HIV AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Bldg 17, Room 4029, M S F08, Atlanta, GA 30333, USA
    Antimicrob Agents Chemother 55:2032-41. 2011
    ..tuberculosis complex. Further, the results can be used to design diagnostic tests utilizing other mutation detection technologies...
  34. ncbi Emergence of new forms of totally drug-resistant tuberculosis bacilli: super extensively drug-resistant tuberculosis or totally drug-resistant strains in iran
    Ali Akbar Velayati
    Mycobacteriology Research Centre, the National Research Institute of Tuberculosis and Lung Disease, World Health Organization Collaborating Centre, Shahid Beheshti University, Darabad, Tehran, Iran
    Chest 136:420-5. 2009
    ..The study documented the emergence of new forms of resistant bacilli (totally drug-resistant [TDR] or super extensively drug-resistant [XDR] tuberculosis [TB] strains) among patients with multidrug-resistant TB (MDR-TB)...
  35. ncbi A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis
    C K Stover
    PathoGenesis Corporation, Seattle, Washington 98119, USA
    Nature 405:962-6. 2000
    ..tuberculosis and promising oral activity in animal infection models. We conclude that nitroimidazopyrans offer the practical qualities of a small molecule with the potential for the treatment of tuberculosis...
  36. pmc Multilocus sequence typing of Klebsiella pneumoniae nosocomial isolates
    Laure Diancourt
    Unité Biodiversité des Bactéries Pathogènes Emergentes U389 INSERM, Institut Pasteur, 25 28 Rue du Dr Roux, 75724 Paris, Cedex 15, France
    J Clin Microbiol 43:4178-82. 2005
    ..Forty distinct allelic profiles were identified. MLST data were validated against ribotyping and showed high (96%) discriminatory power. The MLST approach provides unambiguous data useful for the epidemiology of K. pneumoniae isolates...
  37. pmc Emergence of Pseudomonas aeruginosa strains producing high levels of persister cells in patients with cystic fibrosis
    Lawrence R Mulcahy
    Department of Biology and Antimicrobial Discovery Center, Northeastern University, Boston, Massachusetts 02115, USA
    J Bacteriol 192:6191-9. 2010
    ..Persisters may play a similarly critical role in the recalcitrance of other chronic infections...
  38. pmc Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane
    Anna E Grzegorzewicz
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA
    Nat Chem Biol 8:334-41. 2012
    ....
  39. pmc Prevalence in the United States of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme
    Chi Hye Park
    Division of Infectious Diseases, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114 2696, USA
    Antimicrob Agents Chemother 50:3953-5. 2006
    ..aac(6')-Ib-cr was geographically widespread, stable over time, most common in Escherichia coli, equally prevalent in ciprofloxacin-susceptible and -resistant strains, and not associated with qnr genes...
  40. pmc The Calgary Biofilm Device: new technology for rapid determination of antibiotic susceptibilities of bacterial biofilms
    H Ceri
    Biofilm Research Group, University of Calgary, Calgary, Alberta, Canada T2N 1N4
    J Clin Microbiol 37:1771-6. 1999
    ..The CBD offers a new technology for the rational selection of antibiotics effective against microbial biofilms and for the screening of new effective antibiotic compounds...
  41. ncbi Contemporary causes of skin and soft tissue infections in North America, Latin America, and Europe: report from the SENTRY Antimicrobial Surveillance Program (1998-2004)
    Gary J Moet
    JMI Laboratories, North Liberty, IA 52317, USA
    Diagn Microbiol Infect Dis 57:7-13. 2007
    ..48.0%) when compared with other regions. Continued surveillance of pathogen prevalence and antimicrobial resistance patterns should provide information that is important to improve empiric care particularly in the hospital environment...
  42. pmc Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease
    Leah E Cowen
    Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada
    Proc Natl Acad Sci U S A 106:2818-23. 2009
    ....
  43. ncbi Epidemiology of antituberculosis drug resistance 2002-07: an updated analysis of the Global Project on Anti-Tuberculosis Drug Resistance Surveillance
    Abigail Wright
    Stop TB Department, WHO, Geneva, Switzerland
    Lancet 373:1861-73. 2009
    ..The Global Project on Anti-Tuberculosis Drug Resistance has been gathering data since 1994. This study provides the latest data on the extent of drug resistance worldwide...
  44. pmc High-level cefixime- and ceftriaxone-resistant Neisseria gonorrhoeae in France: novel penA mosaic allele in a successful international clone causes treatment failure
    Magnus Unemo
    WHO Collaborating Centre for Gonorrhoea and Other STIs, Department of Laboratory Medicine, Microbiology, Orebro University Hospital, Orebro, Sweden
    Antimicrob Agents Chemother 56:1273-80. 2012
    ..Nevertheless, new treatment strategies and/or drugs and, ideally, a vaccine are essential to develop for efficacious gonorrhea management...
  45. pmc Is Neisseria gonorrhoeae initiating a future era of untreatable gonorrhea?: detailed characterization of the first strain with high-level resistance to ceftriaxone
    Makoto Ohnishi
    National Institute of Infectious Diseases, Tokyo, Japan
    Antimicrob Agents Chemother 55:3538-45. 2011
    ..Ultimately, the development of new drugs for efficacious gonorrhea treatment is necessary...
  46. pmc Nasal colonization of humans with methicillin-resistant Staphylococcus aureus (MRSA) CC398 with and without exposure to pigs
    Christiane Cuny
    Robert Koch Institute, Wernigerode Branc, Wernigerode, Germany
    PLoS ONE 4:e6800. 2009
    ..The study presented here addresses the question of further transmission to non exposed humans...
  47. pmc Reduced vancomycin susceptibility in Staphylococcus aureus, including vancomycin-intermediate and heterogeneous vancomycin-intermediate strains: resistance mechanisms, laboratory detection, and clinical implications
    Benjamin P Howden
    Department of Infectious Diseases, Austin Health, Victoria, Australia
    Clin Microbiol Rev 23:99-139. 2010
    ..Given the subtleties of vancomycin susceptibility testing against S. aureus, it is imperative that diagnostic laboratories use well-standardized methods and have a framework for detecting reduced vancomycin susceptibility in S. aureus...
  48. ncbi ST11, the dominant clone of KPC-producing Klebsiella pneumoniae in China
    Yan Qi
    Department of Infectious Diseases, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People s Republic of China
    J Antimicrob Chemother 66:307-12. 2011
    ..Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae has spread rapidly in China. In this study, we aimed to investigate the molecular epidemiology of KPC-producing K. pneumoniae isolates in China...
  49. pmc Evaluation of the analytical performance of the Xpert MTB/RIF assay
    Robert Blakemore
    Division of Infectious Disease, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    J Clin Microbiol 48:2495-501. 2010
    ..M. tuberculosis was not detected until at least 10(8) copies of an MTBDRplus amplicon were spiked into 1 ml of sputum, suggesting that false-positive results would be unlikely to occur...
  50. ncbi Are community-associated methicillin-resistant Staphylococcus aureus (MRSA) strains replacing traditional nosocomial MRSA strains?
    Kyle J Popovich
    Division of Infectious Disease, Department of Medicine, Rush University Medical Center, and Division of Infectious Disease, Department of Medicine, Stroger Hospital of Cook County, Chicago, Illinois 60612, USA
    Clin Infect Dis 46:787-94. 2008
    ..We describe the epidemiology of hospital-onset community-associated MRSA bloodstream infections using phenotypic and genotypic analysis...
  51. ncbi Methicillin-resistant S. aureus infections among patients in the emergency department
    Gregory J Moran
    Department of Emergency Medicine, Olive View UCLA Medical Center, Sylmar, Calif 91342, USA
    N Engl J Med 355:666-74. 2006
    ..Methicillin-resistant Staphylococcus aureus (MRSA) is increasingly recognized in infections among persons in the community without established risk factors for MRSA...
  52. pmc Detection of new methicillin-resistant Staphylococcus aureus strains that carry a novel genetic homologue and important virulence determinants
    Artur J Sabat
    Department of Medical Microbiology, University of Groningen, Groningen, The Netherlands
    J Clin Microbiol 50:3374-7. 2012
    ..The worrisome emergence of such toxigenic MRSA strains raises concerns that MRSA strains with enhanced virulence potential and impaired detectability by standard molecular assays may spread in Europe...
  53. pmc Livestock-associated methicillin-resistant Staphylococcus aureus in humans, Europe
    Brigitte A G L van Cleef
    Epidemiology and Surveillance Unit, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Emerg Infect Dis 17:502-5. 2011
    ..Livestock-associated MRSA ST398 accounted for only a small proportion of MRSA isolates from humans; most were from the Netherlands, Belgium, Denmark, and Austria...
  54. pmc Performance assessment of the GenoType MTBDRsl test and DNA sequencing for detection of second-line and ethambutol drug resistance among patients infected with multidrug-resistant Mycobacterium tuberculosis
    Wei Lun Huang
    Reference Laboratory of Mycobacteriology, Research and Diagnostic Center, Centers for Disease Control, Taipei, Taiwan, Republic of China
    J Clin Microbiol 49:2502-8. 2011
    ..We recommend including new alleles consisting of the eis promoter and embB genes in molecular analysis. However, conventional DST is necessary to rule out false-negative results from molecular assays...
  55. pmc Genetic features of blaNDM-1-positive Enterobacteriaceae
    Laurent Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 55:5403-7. 2011
    ..The bla(NDM-1) plasmids coharbored a variety of resistance determinants, including β-lactamase genes, quinolone resistance genes, and 16S RNA methylase genes...
  56. ncbi rpoB gene sequence-based characterization of emerging non-tuberculous mycobacteria with descriptions of Mycobacterium bolletii sp. nov., Mycobacterium phocaicum sp. nov. and Mycobacterium aubagnense sp. nov
    Toidi Adekambi
    Unite des Rickettsies, CNRS UMR 6020 IFR 48, Faculte de Medecine, 27, Boulevard Jean Moulin, Université de la Méditerranée and Assistance Publique Hôpitaux de Marseille Timone, Fédération de Microbiologie Clinique, Marseille, France
    Int J Syst Evol Microbiol 56:133-43. 2006
    ....
  57. pmc Epidemiology and predictors of mortality in cases of Candida bloodstream infection: results from population-based surveillance, barcelona, Spain, from 2002 to 2003
    Benito Almirante
    Infectious Diseases Division, Hospital Universitari Vall d Hebron, Avda Vall d Hebron, 119 129, 08035 Barcelona, Spain
    J Clin Microbiol 43:1829-35. 2005
    ..Antifungal medication and catheter removal are critical in preventing mortality...
  58. ncbi Sampling the antibiotic resistome
    Vanessa M D'Costa
    Antimicrobial Research Centre, Department of Biochemistry and Biomedical Sciences, McMaster University, Ontario, Canada, L8N 3Z5
    Science 311:374-7. 2006
    ..They are a reservoir of resistance determinants that can be mobilized into the microbial community. Study of this reservoir could provide an early warning system for future clinically relevant antibiotic resistance mechanisms...
  59. ncbi Multiplex PCR for genes encoding prevalent OXA carbapenemases in Acinetobacter spp
    Neil Woodford
    Antibiotic Resistance Monitoring and Reference Laboratory, Centre for Infections, Health Protection Agency, 61 Colindale Ave, London NW9 5HT, UK
    Int J Antimicrob Agents 27:351-3. 2006
    ..Genes encoding OXA-58 were detected (with bla(OXA-51-like)) in a cluster of related isolates from a single hospital. This simple assay will assist in monitoring the mechanisms responsible for carbapenem resistance in Acinetobacter spp...
  60. pmc Novel carbapenem-hydrolyzing beta-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae
    H Yigit
    Hospital Infections Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Antimicrob Agents Chemother 45:1151-61. 2001
    ..pneumoniae strain 1534 is mainly due to production of a novel Bush group 2f, class A, carbapenem-hydrolyzing beta-lactamase, KPC-1, although alterations in porin expression may also play a role...
  61. pmc Microscopic-observation drug-susceptibility assay for the diagnosis of TB
    David A J Moore
    Department of Infectious Diseases and Immunity and the Wellcome Centre for Clinical Tropical Medicine, Imperial College London, Faculty of Medicine Hammersmith Campus, London, United Kingdom
    N Engl J Med 355:1539-50. 2006
    ....
  62. pmc Prevalence of livestock-associated MRSA in communities with high pig-densities in The Netherlands
    Brigitte A van Cleef
    Centre for Infectious Disease Control Netherlands, RIVM National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    PLoS ONE 5:e9385. 2010
    ..This cross-sectional study aimed to determine the spread to persons not in direct contact with livestock in areas with a high density of pig farms...
  63. pmc Agr-mediated dispersal of Staphylococcus aureus biofilms
    Blaise R Boles
    Department of Microbiology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
    PLoS Pathog 4:e1000052. 2008
    ..These findings indicate that induction of the agr system in established S. aureus biofilms detaches cells and demonstrate that the dispersal mechanism requires extracellular protease activity...
  64. pmc Community-acquired methicillin-resistant Staphylococcus aureus carrying Panton-Valentine leukocidin genes: worldwide emergence
    Francois Vandenesch
    INSERM E0230, Lyon, France
    Emerg Infect Dis 9:978-84. 2003
    ..Within each continent, the genetic background of CA-MRSA strains did not correspond to that of the hospital-acquired MRSA...
  65. ncbi Isolation and characterization of human beta -defensin-3, a novel human inducible peptide antibiotic
    J Harder
    Clinical Research Unit, Department of Dermatology, University Hospital Kiel, Schittenhelmstrasse 7, 24105 Kiel, Germany
    J Biol Chem 276:5707-13. 2001
    ..hBD-3 therefore might be important in the innate epithelial defense of infections by various microorganisms seen in skin and lung, such as cystic fibrosis...
  66. pmc Complete genome sequence of the multiresistant taxonomic outlier Pseudomonas aeruginosa PA7
    Paul H Roy
    Departement de Biochimie et de Microbiologie, and Centre de recherche en infectiologie, Universite Laval, Quebec, Quebec, Canada
    PLoS ONE 5:e8842. 2010
    ..PA7 is serotype O12 and pyoverdin type II. Preliminary proteomic studies indicate numerous differences with PAO1, some of which are probably a consequence of a frameshift mutation in the mvfR quorum sensing regulatory gene...
  67. ncbi Molecular epidemiology of community-associated meticillin-resistant Staphylococcus aureus in Europe
    Jonathan A Otter
    Department of Infection, King s College London and St Thomas Hospital, London, UK
    Lancet Infect Dis 10:227-39. 2010
    ..An understanding of the epidemiology of community-associated MRSA is essential to guide new control initiatives to prevent these organisms from becoming endemic in Europe...
  68. ncbi The diarylquinoline TMC207 for multidrug-resistant tuberculosis
    Andreas H Diacon
    Centre for Clinical Tuberculosis Research, the Department of Science and Technology, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, all in South Africa
    N Engl J Med 360:2397-405. 2009
    ..TMC207 potently inhibits drug-sensitive and drug-resistant Mycobacterium tuberculosis in vitro and shows bactericidal activity in patients who have drug-susceptible pulmonary tuberculosis...
  69. ncbi Silver colloid nanoparticles: synthesis, characterization, and their antibacterial activity
    Ales Panacek
    Department of Physical Chemistry, Palacky University, Svobody 26, 771 46 Olomouc, Czech Republic
    J Phys Chem B 110:16248-53. 2006
    ..Antibacterial activity of silver nanoparticles was found to be dependent on the size of silver particles. A very low concentration of silver (as low as 1.69 mug/mL Ag) gave antibacterial performance...
  70. pmc Bacteroides: the good, the bad, and the nitty-gritty
    Hannah M Wexler
    Wadsworth Anaerobe Laboratory, Greater Los Angeles VA Healthcare Systems University of California, Los Angeles, CA 90073, USA
    Clin Microbiol Rev 20:593-621. 2007
    ..Clinically, Bacteroides species have exhibited increasing resistance to many antibiotics, including cefoxitin, clindamycin, metronidazole, carbapenems, and fluoroquinolones (e.g., gatifloxacin, levofloxacin, and moxifloxacin)...
  71. ncbi Prevalence and characterisation of CTX-M β-lactamases amongst Escherichia coli isolates from healthy food animals in China
    Hongqing Zheng
    College of Veterinary Medicine, National Reference Laboratory of Veterinary Drug Residues, South China Agricultural University, Guangzhou 510642, China
    Int J Antimicrob Agents 39:305-10. 2012
    ..This study demonstrates that commensal E. coli from healthy food animals can be important reservoirs of bla(CTX-M) genes and may contribute to the dissemination and transfer of these β-lactamase genes throughout China...
  72. ncbi Pneumococcal serotype distribution and antimicrobial resistance in Chinese children hospitalized for pneumonia
    Kai Hu Yao
    Beijing Pediatric Research Institute, Beijing Children s Hospital Affiliated to Capital Medical University, Beijing, China
    Vaccine 29:2296-301. 2011
    ..The use of PCV7 has the potential to prevent a substantial number of pneumococcal infections. However, PCV13 is likely to prevent more episodes of pneumococcal disease in China because of the high rates of 19A...
  73. pmc Population structure of Staphylococcus aureus from remote African Babongo Pygmies
    Frieder Schaumburg
    Institute of Medical Microbiology, University of Munster, Munster, Germany
    PLoS Negl Trop Dis 5:e1150. 2011
    ..The objective of our study was to investigate the S. aureus carriage among a remote indigenous African population and to determine the molecular characteristics of the isolates, particularly those that were PVL-positive...
  74. ncbi Molecular mechanisms disrupting porin expression in ertapenem-resistant Klebsiella and Enterobacter spp. clinical isolates from the UK
    Michel Doumith
    Antibiotic Resistance Monitoring and Reference Laboratory, Health Protection Agency, Centre for Infections, 61 Colindale Avenue, London NW95EQ, UK
    J Antimicrob Chemother 63:659-67. 2009
    ..n = 28) and Enterobacter spp. (n = 27) referred from multiple hospitals to the UK national reference laboratory...
  75. pmc Class 1 integrons and tetracycline resistance genes in alcaligenes, arthrobacter, and Pseudomonas spp. isolated from pigsties and manured soil
    Yvonne Agersø
    Danish Food and Veterinary Research, Section of Antimicrobial Resistance, Bulowsvej 27, 1790 Copenhagen V, Denmark
    Appl Environ Microbiol 71:7941-7. 2005
    ..Use of tetracyclines in food animal production may increase not only Tc(r) but also multidrug resistance (caused by the presence tet genes and in-1) in bacteria...
  76. pmc Emergence of NDM-1 metallo-β-lactamase in Pseudomonas aeruginosa clinical isolates from Serbia
    Branko Jovcic
    Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, Serbia
    Antimicrob Agents Chemother 55:3929-31. 2011
    ..Five additional isolates from different patients clonally related to either MMA83 or MMA533 were found to be NDM-1 positive...
  77. ncbi GenoType MTBDR assays for the diagnosis of multidrug-resistant tuberculosis: a meta-analysis
    D I Ling
    Dept of Epidemiology, Biostatistics and Occupational Health, McGill University, 1020 Pine Avenue West, Montreal, QC H3A 1A2, Canada
    Eur Respir J 32:1165-74. 2008
    ..While specificity is excellent for isoniazid, sensitivity estimates were modest and variable. Together with data from demonstration projects, the meta-analysis provides evidence for policy making and clinical practice...
  78. ncbi Multiplex PCR strategy for subtyping the staphylococcal cassette chromosome mec type IV in methicillin-resistant Staphylococcus aureus: 'SCCmec IV multiplex'
    Catarina Milheiriço
    Laboratory of Molecular Genetics, Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Oeiras, Portugal
    J Antimicrob Chemother 60:42-8. 2007
    ..To develop and validate a new multiplex PCR strategy for subtyping SCCmec type IV methicillin-resistant Staphylococcus aureus (MRSA) strains-SCCmec IV multiplex PCR...
  79. ncbi Antimicrobial resistance: Not community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA)! A clinician's guide to community MRSA - its evolving antimicrobial resistance and implications for therapy
    Kyra Chua
    Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia
    Clin Infect Dis 52:99-114. 2011
    ..Continued monitoring of global epidemiology and emerging drug resistance data is critical for the effective management of these infections...
  80. ncbi An outbreak of infection due to beta-Lactamase Klebsiella pneumoniae Carbapenemase 2-producing K. pneumoniae in a Greek University Hospital: molecular characterization, epidemiology, and outcomes
    Maria Souli
    4th Dept of Internal Medicine, University General Hospital Attikon, 1 Rimini Str 124 62, Chaidari, Greece
    Clin Infect Dis 50:364-73. 2010
    ..We describe the emergence and spread of Klebsiella pneumoniae carbapenemase 2 (KPC-2)-producing K. pneumoniae at a Greek University hospital...
  81. ncbi Commensal Escherichia coli of healthy humans: a reservoir for antibiotic-resistance determinants
    Jannine K Bailey
    School of Molecular Bioscience, The University of Sydney, NSW 2006, Australia
    J Med Microbiol 59:1331-9. 2010
    ..coli of healthy humans represent an important reservoir for numerous antibiotic-resistance genes in many combinations. However, measuring the true extent of resistance carriage in commensal E. coli requires in-depth analysis...
  82. pmc Trends in antimicrobial resistance among urinary tract infection isolates of Escherichia coli from female outpatients in the United States
    James A Karlowsky
    Focus Technologies, Inc, 13665 Dulles Technology Drive, Suite 200, Herndon, VA 20171 4603, USA
    Antimicrob Agents Chemother 46:2540-5. 2002
    ..8 to 17.0%) from 1995 to 2001 but demonstrated considerable regional and institutional variation in 2001. Therapies other than SXT may need to be considered in some locations...
  83. ncbi Multiple mechanisms of antimicrobial resistance in Pseudomonas aeruginosa: our worst nightmare?
    David M Livermore
    Antibiotic Resistance Monitoring and Reference Laboratory, Central Public Health Laboratory, Colindale, London, United Kingdom
    Clin Infect Dis 34:634-40. 2002
    ..A few isolates of P. aeruginosa are resistant to all reliable antibiotics, and this problem seems likely to grow with the emergence of integrins that carry gene cassettes encoding both carbapenemases and amikacin acetyltransferases...
  84. ncbi Carbapenem resistance among Klebsiella pneumoniae isolates: risk factors, molecular characteristics, and susceptibility patterns
    Khetam Hussein
    Infectious Diseases Unit, Rambam Medical Center, Haifa, Israel
    Infect Control Hosp Epidemiol 30:666-71. 2009
    ..Carbapenem resistance among isolates of Klebsiella pneumoniae has been unusual...
  85. ncbi Resistance among Streptococcus pneumoniae: Implications for drug selection
    Peter C Appelbaum
    Departments of Pathology and Clinical Microbiology, Milton S Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA
    Clin Infect Dis 34:1613-20. 2002
    ..Efforts should be made to prevent pneumococcal infections in high-risk patients through vaccination...
  86. ncbi Antimicrobial activity of the crude extracts and compounds from Ficus chlamydocarpa and Ficus cordata (Moraceae)
    V Kuete
    Department of Biochemistry, Faculty of Science, University of Dschang, P O BOX 67, Dschang, Cameroon
    J Ethnopharmacol 120:17-24. 2008
    ..FCB was found to be more active than FCR on most of the tested organisms. The results provided evidence that the studied plants extract, as well as some of the isolated compounds might be potential sources of new antimicrobial drug...
  87. ncbi Anti-staphylococcal plant natural products
    Simon Gibbons
    Centre for Pharmacognosy and Phytotherapy, University of London School of Pharmacy, 29 39 Brunswick Square, London, UKWC1N 1AX
    Nat Prod Rep 21:263-77. 2004
  88. pmc Continued impact of pneumococcal conjugate vaccine on carriage in young children
    Susan S Huang
    Division of Infectious Diseases, School of Medicine, University of California, Irvine, Orange, CA 92868, USA
    Pediatrics 124:e1-11. 2009
    ....
  89. pmc AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutants
    H Okusu
    Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    J Bacteriol 178:306-8. 1996
    ..This experiment identified the AcrAB system as the major pump responsible for making the Mar mutants resistant to many agents, including tetracycline, chloramphenicol, ampicillin, nalidixic acid, and rifampin...
  90. pmc Synergistic effect of calcineurin inhibitors and fluconazole against Candida albicans biofilms
    Priya Uppuluri
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Antimicrob Agents Chemother 52:1127-32. 2008
    ..These findings reveal that calcineurin contributes to fluconazole resistance of biofilms and provide evidence that synergistic drug combinations may prove efficacious as novel therapeutic interventions to treat or prevent biofilms...
  91. ncbi Population snapshot of emergent Streptococcus pneumoniae serotype 19A in the United States, 2005
    Matthew R Moore
    Respiratory Diseases Branch, Centers for Disease Control and Prevention, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA
    J Infect Dis 197:1016-27. 2008
    ..To understand this increase, we characterized serotype 19A isolates recovered during 2005...
  92. pmc Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa: novel agents for combination therapy
    O Lomovskaya
    Microcide Pharmaceuticals, Inc, Mountain View, California 94043, USA
    Antimicrob Agents Chemother 45:105-16. 2001
    ..aeruginosa strains that are highly resistant to fluoroquinolones...
  93. ncbi Antibacterial properties of Ag nanoparticle loaded multilayers and formation of magnetically directed antibacterial microparticles
    Daeyeon Lee
    Department of Chemical Engineering and the Center for Materials Science and Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Langmuir 21:9651-9. 2005
    ..The minimum inhibitory concentration (MIC) of nanocomposite coated microspheres was determined by the agar dilution technique: antibacterial magnetic microspheres with higher concentrations of Ag nanoparticles exhibited lower MIC values...
  94. ncbi Fluoroquinolones, tuberculosis, and resistance
    Amy Sarah Ginsburg
    Center for Tuberculosis Research, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Lancet Infect Dis 3:432-42. 2003
    ..Discussion and education regarding appropriate use are necessary to preserve the effectiveness of this antibiotic class against the hazard of growing resistance...
  95. pmc Carbapenemases: the versatile beta-lactamases
    Anne Marie Queenan
    Johnson and Johnson Pharmaceutical Research and Development, L L C, Raritan, NJ 08869, USA
    Clin Microbiol Rev 20:440-58, table of contents. 2007
    ..This review updates the characteristics, epidemiology, and detection of the carbapenemases found in pathogenic bacteria...
  96. ncbi Identification and characterization of novel reptile cathelicidins from elapid snakes
    Hui Zhao
    Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming, Yunnan 650223, China
    Peptides 29:1685-91. 2008
    ..Snake cathelicidins also showed a close relationship with avian fowlicidins (1-3) and chicken myeloid antimicrobial peptide 27. Elapid cathelicidins might be used as models for the development of novel therapeutic drugs...
  97. pmc Accessory gene regulator (agr) locus in geographically diverse Staphylococcus aureus isolates with reduced susceptibility to vancomycin
    George Sakoulas
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
    Antimicrob Agents Chemother 46:1492-502. 2002
    ..These findings imply that compromised agr function is advantageous to clinical isolates of S. aureus toward the development of vancomycin heteroresistance, perhaps through the development of vancomycin tolerance...
  98. ncbi Dissemination in Japanese hospitals of strains of Staphylococcus aureus heterogeneously resistant to vancomycin
    K Hiramatsu
    Department of Bacteriology, Juntendo University, Tokyo, Japan
    Lancet 350:1670-3. 1997
    ..Two important questions need to be answered: (1) what is the prevalence of VRSA, and (2) by what mechanism does vancomycin resistance occur...
  99. ncbi Virulence and drug resistance roles of multidrug efflux systems of Salmonella enterica serovar Typhimurium
    Kunihiko Nishino
    Department of Molecular Microbiology, Howard Hughes Medical Institute, Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, USA
    Mol Microbiol 59:126-41. 2006
    ..The PhoP/PhoQ two-component system is a major regulator of Salmonella virulence, which underscores the connection between drug efflux systems and virulence...
  100. pmc New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate
    Kunikazu Yamane
    Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashi Murayama, Tokyo 208 0011, Japan
    Antimicrob Agents Chemother 51:3354-60. 2007
    ..coli was first identified. Surveillance of the qepA-harboring clinical isolates should be encouraged to minimize further dissemination of the kind of plasmid-dependent FQ resistance determinants among pathogenic microbes...
  101. ncbi Identification and characterization of methicillin-resistant coagulase-negative staphylococci from bovine mastitis
    Andrea T Fessler
    Institute of Farm Animal Genetics, Friedrich Loeffler Institut FLI, Neustadt Mariensee, Germany
    J Antimicrob Chemother 65:1576-82. 2010
    ....

Research Grants55

  1. Nitogen reduction and xenobiotic response
    Lauren A Trepanier; Fiscal Year: 2010
    ..The ultimate goal of these studies is to find better ways to prevent these adverse reactions. ..
  2. Novel antibacterial agents for treatment of Tularemia
    Nachum Kaplan; Fiscal Year: 2004
    ..tularensis microbiological data and animal model data to warrant inclusion of the information on the product label as a narrow spectrum agent that could be used in the event of a F. tularensis release. ..
  3. Host Cell Killing by EPEC: Central Role in Pathogenesis
    JOHN CRANE; Fiscal Year: 2005
    ..coli (RDEC-1) and rabbit EPEC (REPEC). ..
  4. Validation of topography-biased antibody libraries
    Sylvia Smith; Fiscal Year: 2005
    ..Furthermore, this study will lay the foundation for further development of highly specific and high affinity antibodies to a diverse array of toxins. ..
  5. C. Perfringens to Induce Anti-HIV Mucosal Immunity
    Phalguni Gupta; Fiscal Year: 2006
    ..The proposed study provides a novel strategy to induce strong mucosal immunity against HIV-1 which can lead to development of an anti-HlV-1 oral vaccine due to its safety, low production cost and easy administration. ..
  6. Novel Inorganic Nucleases
    James Cowan; Fiscal Year: 2006
    ..abstract_text> ..
  7. Therapeutic vaccine against tuberculosis
    Lee Riley; Fiscal Year: 2006
    ..Therapeutic vaccines against TB is a major priority in TB control, and we have an opportunity to identify such products by a novel approach using a simple, inexpensive, and reproducible animal model. ..
  8. Effect of Zinc in Enteropathogenic E. coli Infection
    JOHN CRANE; Fiscal Year: 2006
    ..abstract_text> ..
  9. Plasmid-Mediated Quinolone Resistance
    George Jacoby; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  10. Neonatal Immunization with Acellular Pertussis Vaccines
    Natasha Halasa; Fiscal Year: 2007
    ....
  11. Orgin of multidrug resistant uropathogenic E. coli
    Lee Riley; Fiscal Year: 2008
    ..This knowledge should lead to the implementation of improved control of drug-resistant infectious diseases. ..
  12. CV-N Secreting Lactobacilli and Retrocyclin Microbicides
    Phalguni Gupta; Fiscal Year: 2008
    ..The development of a combination microbicide product that incorporates CV-N/LAB and retrocyclin would provide a novel strategy which is expected to have potent anti-HIV activity without inducing cellular toxicity. ..
  13. SEMEN IN TRANSMISSION OF HIV
    Phalguni Gupta; Fiscal Year: 2010
    ..The information from the proposed study will be extremely useful to our understanding of transmission and eradication of HIV-1 following therapy. ..
  14. Novel Engineered Synthetic Metallodrugs Directed Against HCV
    San Ching; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  15. In vivo regulation of M. tuberculosis cell wall lipids
    Lee W Riley; Fiscal Year: 2010
    ..tuberculosis and granulomas may contribute to our understanding of the mechanism of persistence of M. tuberculosis that could lead to new tests to differentiate active TB from latent TB infection. ..
  16. Enteropathogenic and Toxigenic E.coli Interactions
    JOHN CRANE; Fiscal Year: 2004
    ..abstract_text> ..
  17. ORGAN CULTURE TO STUDY HIV TRANSMISSION
    Phalguni Gupta; Fiscal Year: 2003
    ....
  18. ASSESSMENT OF CD8 SUPPRESSION OF HIV/SIV TO VACCINES
    Phalguni Gupta; Fiscal Year: 2002
    ..The information generated from this project will be extremely useful in determining the utility of the suppressive activity in evaluating efficacy of a vaccine. ..
  19. MOLECULAR BIOLOGY OF INFECTION WITH M TUBERCULOSIS
    Lee Riley; Fiscal Year: 2002
    ..In addition, these studies may identify several potential targets for new chemotherapeutic agents or vaccine candidates. ..
  20. ANTIOXIDANT GENES OF MYCOBACERIUM TUBERCULOSIS
    Lee Riley; Fiscal Year: 2001
    ....
  21. Epidemiology of an uropathogenic E coli clonal group
    Lee Riley; Fiscal Year: 2003
    ..coli can be spread by contaminated ingestible vehicles, and use the data generated from this project to design long-term studies to better characterize risk factors associated with CgA infection. ..
  22. HIV IN SEMEN FROM INFECTED SUBJECTS FROM INDIA
    Phalguni Gupta; Fiscal Year: 2006
    ..Semen and blood plasma and mononuclear cells samples collected through our collaborative study in India will be used in this project. [unreadable] [unreadable]..
  23. BCG + hsp, a New Tuberculosis Vaccine
    Boris Nikonenko; Fiscal Year: 2003
    ..We will also examine the antibiotic sensitivity of this rBCGdeltahspR to 10 commonly used TB drugs to ensure that the genetic manipulations performed have not made it less sensitive to drug treatment. ..
  24. Cytology and function of ParA in E. coli
    JOSEPH A POGLIANO; Fiscal Year: 2010
    ..The findings from this analysis of a representative ParAB plasmid partitioning system should have wide implications for our understanding of plasmid and chromosome segregation. ..
  25. C. difficile Toxin Membrane Test with Magnetic Particles
    ROBERT CARMAN; Fiscal Year: 2004
    ..perfringens enterotoxin, another cause of AAD. The technology developed in this project will be widely applicable for the development of new highly sensitive stool antigen tests. ..
  26. SALIVARY PROTEINS IN DENTAL INTEGUMENTS
    FRANK OPPENHEIM; Fiscal Year: 2009
    ..abstract_text> ..
  27. Molecular Target Focused Discovery of Anticancer Drugs
    George R Pettit; Fiscal Year: 2010
    ....
  28. Evolution of Stress-Induced Bacterial Toxins
    Margaret A Riley; Fiscal Year: 2010
    ....
  29. Office for Access to Biomedical Research and Training
    CHARLES BIGGER; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  30. MOLECULAR EVOLUTION OF ENTERIC BACTERIOCINS
    Margaret Riley; Fiscal Year: 2002
    ..we gain regarding the natural role of bacteriocins, and the defenses raised against them within bacterial communities, can be directly applied to the rational application of novels antimicrobials to human health issues ..
  31. ORIGIN AND DYNAMICS OF HIV-1 IN SEMEN
    Phalguni Gupta; Fiscal Year: 2002
    ..The information from the proposed study will be extremely useful in the understanding of transmission and eradication of HIV following therapy. ..
  32. Developing Murine Models of HCV Replication
    SUSAN UPRICHARD; Fiscal Year: 2004
    ..abstract_text> ..
  33. Polymyxin-resistant Pseudomonas in CF Lung Infection
    Samuel M Moskowitz; Fiscal Year: 2010
    ..An interdisciplinary study of polymyxin resistant Pseudomonas from patients with cystic fibrosis is proposed to pinpoint the bacterial genes responsible for this resistance, so that management strategies may be devised to overcome it. ..
  34. Clinical Impact of Quinolone-Resistant E.coli carriage
    Ebbing Lautenbach; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  35. Cryptococcus gatti mating 1oci; mapping and gene study
    Vishnu Chaturvedi; Fiscal Year: 2004
    ..abstract_text> ..
  36. DETECTING NEONATAL SEPSIS USING MOLECULAR TECHNIQUES
    JEANNE JORDAN; Fiscal Year: 2003
    ....
  37. Rural Trial of Clinic Order Entry with Decision Support
    Matthew Samore; Fiscal Year: 2006
    ..The cost impact of the intervention will be measured to allow a comprehensive assessment of the value of this HIT. [unreadable] [unreadable]..
  38. BACTERIAL MODULATION OF LUNG INFLAMMATORY RESPONSE
    Thomas Russo; Fiscal Year: 2004
    ..g. hemolysin) and bacterially induced host response elements in directly mediating the pathogenesis of lung injury. ..
  39. CANDIDA PATHOGENESIS IN SURGERY AND TRAUMA
    Carol Wells; Fiscal Year: 2007
    ..Such knowledge should accelerate our ability to diagnose, treat, and control systemic candidiasis. ..
  40. Biofilm growth and detachment of an oral pathogen
    Jeffrey Kaplan; Fiscal Year: 2007
    ..abstract_text> ..
  41. Bacterial DnaA Initiator Protein: A Target for Novel Antibiotics
    Michelle Butler; Fiscal Year: 2008
    ..This proposal describes a new type of screening assay that can identify inhibitors of DnaA, a previously unexploited protein involved in the initiation of DNA synthesis. [unreadable] [unreadable] [unreadable]..
  42. A NOVEL THERAPY FOR RESPIRATORY SYNCYTIAL VIRUS
    Michelle Butler; Fiscal Year: 2003
    ..The goal is to file an IND within three years of initiation of the Phase I SBIR studies. ..
  43. DEVELOPMENT OF SCREENS FOR BACILLUS ANTHRACIS TARGETS
    Michelle Butler; Fiscal Year: 2005
    ..In Phase II, we will optimize the most promising compounds to develop novel leads and candidate drugs for pre-clinical testing in animal models of infection. ..
  44. DEVELOPMENT OF INHIBITORS OF MYCOBACTERIUM TUBERCULOSIS DNA REPLICATION
    Michelle Butler; Fiscal Year: 2007
    ..In Phase II, we will optimize the most promising compounds to develop novel leads and candidate drugs for pre-clinical testing in animal models of infection. [unreadable] [unreadable] [unreadable]..
  45. BACTERIAL DNA POLYMERASES: TARGET FOR NOVEL ANTIBIOTICS
    Michelle Butler; Fiscal Year: 2005
    ..The SAR development and in vitro and in vivo characterization studies are the subject of this Phase II application. ..
  46. MODELS FOR TESTING CANDIDATE TOPICAL MICROBICIDES FOR CYTOTOXICITY AND ACTIVITY A
    Mary Lampe; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  47. Molecular Target Focused Discovery of Anticancer Drugs
    GEORGE PETTIT; Fiscal Year: 2007
    ..In summary, the proposed research will be sharply aimed at the discovery and very rapid development of new anticancer drugs for the NCI programs direct at improving human cancer treatments. ..
  48. HELICOBACTER DIAGNOSTIC ASSAYS FOR LABORATORY MICE
    Stephen Barthold; Fiscal Year: 2004
    ..abstract_text> ..
  49. Mechanisms of Tandem Repeat Deletion in Group B Strep
    KAREN PUOPOLO; Fiscal Year: 2006
    ..The training goal of this project is to prepare the applicant for a career in bacterial genetic research by providing didactic education and the opportunity to develop laboratory expertise in this rapidly evolving field. ..
  50. IgA inducing peptide
    D Estes; Fiscal Year: 2005
    ..In addition, the proposed studies will begin to examine determine the potential relationship between IGIP and clinical abnormality in IgA production. ..
  51. 3RD ANNUAL MUTANT MOUSE REGIONAL RESOURCE CENTER MEETING
    Stephen Barthold; Fiscal Year: 2003
    ....
  52. 5th Comparative Medicine Resource Center Director Mtg.
    Stephen Barthold; Fiscal Year: 2008
    ....