microbial colony count

Summary

Summary: Enumeration by direct count of viable, isolated bacterial, archaeal, or fungal CELLS or SPORES capable of growth on solid CULTURE MEDIA. Each colony (i.e., microbial colony-forming unit) represents the progeny of a single cell in the original inoculum. The method is used routinely by environmental microbiologists for quantifying organisms in AIR; FOOD; and WATER; by clinicians for measuring patients' microbial load; and in antimicrobial drug testing.

Top Publications

  1. ncbi Phage therapy reduces Campylobacter jejuni colonization in broilers
    Jaap A Wagenaar
    Division of Infectious Diseases, Animal Sciences Group, P O Box 65, 8200 AB Lelystad, The Netherlands
    Vet Microbiol 109:275-83. 2005
  2. ncbi New three-stage in vitro model for infant colonic fermentation with immobilized fecal microbiota
    Cécile Cinquin
    Dairy Research Centre STELA, Pavillon Paul Comtois, Universite Laval, Quebec, QC, Canada
    FEMS Microbiol Ecol 57:324-36. 2006
  3. pmc Cell density and mobility protect swarming bacteria against antibiotics
    Mitchell T Butler
    University of Texas, Austin, TX 78712, USA
    Proc Natl Acad Sci U S A 107:3776-81. 2010
  4. ncbi Inhibition of Staphylococcus aureus by the commensal bacteria of human milk
    M P Heikkilä
    Department of Applied Chemistry and Microbiology, University of Helsinki, Helsinki, Finland
    J Appl Microbiol 95:471-8. 2003
  5. ncbi Similar bifidogenic effects of prebiotic-supplemented partially hydrolyzed infant formula and breastfeeding on infant gut microbiota
    Minna M Rinne
    The University of Turku, 20014 Turku, Finland Department of Pediatrics, Turku University Central Hospital, 20520 Turku, Finland
    FEMS Immunol Med Microbiol 43:59-65. 2005
  6. pmc Bacterial competition for human nasal cavity colonization: role of Staphylococcal agr alleles
    Gerard Lina
    Centre National de Référence des Staphylocoques, INSERM E 0230, IFR 62, Faculte de Medecine Laennec, Lyon, France
    Appl Environ Microbiol 69:18-23. 2003
  7. pmc A member of the cAMP receptor protein family of transcription regulators in Mycobacterium tuberculosis is required for virulence in mice and controls transcription of the rpfA gene coding for a resuscitation promoting factor
    Lisa Rickman
    Division of Mycobacterial Research, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    Mol Microbiol 56:1274-86. 2005
  8. pmc Susceptibility of biofilms to Bdellovibrio bacteriovorus attack
    Daniel Kadouri
    Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755, USA
    Appl Environ Microbiol 71:4044-51. 2005
  9. ncbi Culture-independent methods for identifying microbial communities in cheese
    Jean Luc Jany
    Laboratoire Universitaire de Biodiversité et Ecologie Microbienne, Université Européenne de Bretagne ESMISAB, Parvis Blaise Pascal, Technopôle de Brest Iroise, Plouzane, France
    Food Microbiol 25:839-48. 2008
  10. ncbi Airway bacterial concentrations and exacerbations of chronic obstructive pulmonary disease
    Sanjay Sethi
    Veterans Affairs Western New York Healthcare System 151, 3495 Bailey Avenue, Buffalo, NY 14215, USA
    Am J Respir Crit Care Med 176:356-61. 2007

Detail Information

Publications266 found, 100 shown here

  1. ncbi Phage therapy reduces Campylobacter jejuni colonization in broilers
    Jaap A Wagenaar
    Division of Infectious Diseases, Animal Sciences Group, P O Box 65, 8200 AB Lelystad, The Netherlands
    Vet Microbiol 109:275-83. 2005
    ..This again resulted in a significant decrease in Campylobacter colonization. We conclude that phage treatment is a promising alternative for reducing C. jejuni colonization in broilers...
  2. ncbi New three-stage in vitro model for infant colonic fermentation with immobilized fecal microbiota
    Cécile Cinquin
    Dairy Research Centre STELA, Pavillon Paul Comtois, Universite Laval, Quebec, QC, Canada
    FEMS Microbiol Ecol 57:324-36. 2006
    ..These results demonstrate that this new three-stage continuous culture with immobilized cells provides a useful tool for studying the infant colon ecosystem...
  3. pmc Cell density and mobility protect swarming bacteria against antibiotics
    Mitchell T Butler
    University of Texas, Austin, TX 78712, USA
    Proc Natl Acad Sci U S A 107:3776-81. 2010
    ..This work has relevance to the adaptive antibiotic resistance of bacterial biofilms...
  4. ncbi Inhibition of Staphylococcus aureus by the commensal bacteria of human milk
    M P Heikkilä
    Department of Applied Chemistry and Microbiology, University of Helsinki, Helsinki, Finland
    J Appl Microbiol 95:471-8. 2003
    ..To study the bacterial diversity in expressed human milk with a focus on detecting bacteria with an antimicrobial activity against Staphylococcus aureus, known as a causative agent of maternal breast infections and neonatal infections...
  5. ncbi Similar bifidogenic effects of prebiotic-supplemented partially hydrolyzed infant formula and breastfeeding on infant gut microbiota
    Minna M Rinne
    The University of Turku, 20014 Turku, Finland Department of Pediatrics, Turku University Central Hospital, 20520 Turku, Finland
    FEMS Immunol Med Microbiol 43:59-65. 2005
    ..This would suggest that early gut Bifidobacterium microbiota can be modified by special diets up to the age of 6 months...
  6. pmc Bacterial competition for human nasal cavity colonization: role of Staphylococcal agr alleles
    Gerard Lina
    Centre National de Référence des Staphylocoques, INSERM E 0230, IFR 62, Faculte de Medecine Laennec, Lyon, France
    Appl Environ Microbiol 69:18-23. 2003
    ....
  7. pmc A member of the cAMP receptor protein family of transcription regulators in Mycobacterium tuberculosis is required for virulence in mice and controls transcription of the rpfA gene coding for a resuscitation promoting factor
    Lisa Rickman
    Division of Mycobacterial Research, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    Mol Microbiol 56:1274-86. 2005
    ..In summary, it has been shown that Rv3676 is a direct regulator of rpfA expression, and because rpfA codes for a resuscitation promoting factor this may implicate Rv3676 in reactivation of dormant M. tuberculosis infections...
  8. pmc Susceptibility of biofilms to Bdellovibrio bacteriovorus attack
    Daniel Kadouri
    Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755, USA
    Appl Environ Microbiol 71:4044-51. 2005
    ..In flow cell experiments B. bacteriovorus was able to decrease the biomass of both E. coli and Pseudomonas fluorescens biofilms as determined by phase-contrast and epifluorescence microscopy...
  9. ncbi Culture-independent methods for identifying microbial communities in cheese
    Jean Luc Jany
    Laboratoire Universitaire de Biodiversité et Ecologie Microbienne, Université Européenne de Bretagne ESMISAB, Parvis Blaise Pascal, Technopôle de Brest Iroise, Plouzane, France
    Food Microbiol 25:839-48. 2008
    ..Further, our analysis draws attention to the lack of data available on suitable DNA sequences for identifying fungal communities in cheese and proposes some potential DNA targets...
  10. ncbi Airway bacterial concentrations and exacerbations of chronic obstructive pulmonary disease
    Sanjay Sethi
    Veterans Affairs Western New York Healthcare System 151, 3495 Bailey Avenue, Buffalo, NY 14215, USA
    Am J Respir Crit Care Med 176:356-61. 2007
    ..Bacterial concentrations are higher during exacerbation than during stable disease; however, these studies are cross sectional and devoid of strain typing...
  11. ncbi The capacity of nondigestible carbohydrates to stimulate fecal bifidobacteria in healthy humans: a double-blind, randomized, placebo-controlled, parallel-group, dose-response relation study
    Yoram Bouhnik
    Department of Gastroenterology and the Therapeutic Research Unit, Hopital Lariboisiere, Paris, France
    Am J Clin Nutr 80:1658-64. 2004
    ..Nondigestible carbohydrates (NDCHs) are fermented in the colon, where they can selectively promote the growth of bifidobacteria...
  12. ncbi The role of parasites in sympatric and allopatric host diversification
    Angus Buckling
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Nature 420:496-9. 2002
    ..These results show that exploiters can drive diversification between populations, but may inhibit diversification within populations by opposing diversifying selection that arises from resource competition...
  13. pmc An improved protocol for quantification of freshwater Actinobacteria by fluorescence in situ hybridization
    Raju Sekar
    Max Planck Institute for Marine Microbiology, Celciusstrasse 1, D 28359 Bremen, Germany
    Appl Environ Microbiol 69:2928-35. 2003
    ..Our findings confirm that members of this lineage are among the numerically most important Bacteria of freshwater picoplankton...
  14. pmc Development of a synthetic minimal medium for Listeria monocytogenes
    Hsiang Ning Tsai
    Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, United Kingdom
    Appl Environ Microbiol 69:6943-5. 2003
    ..Complex broth-grown L. monocytogenes had to adapt to HTM by inducing amino acid biosyntheis. HTM is the simplest minimal medium available for growth of L. monocytogenes...
  15. ncbi Computational improvements reveal great bacterial diversity and high metal toxicity in soil
    Jason Gans
    Bioscience Division, Los Alamos National Laboratory, Los Alamos, NM 87501, USA
    Science 309:1387-90. 2005
    ..Metal pollution reduced diversity more than 99.9%, revealing the highly toxic effect of metal contamination, especially for rare taxa...
  16. pmc Phylogenetic diversity, abundance, and axial distribution of bacteria in the intestinal tract of two soil-feeding termites (Cubitermes spp.)
    Dirk Schmitt-Wagner
    Mikrobielle Okologie, Fachbereich Biologie, Universitat Konstanz, 78457 Konstanz, Germany
    Appl Environ Microbiol 69:6007-17. 2003
    ..Schmitt-Wagner, M. W. Friedrich, B. Wagner, and A. Brune, Appl. Environ. Microbiol. 69:6018-6024, 2003) corroborated the presence of compartment-specific bacterial communities in the gut of different Cubitermes species...
  17. ncbi Microbiological effects of consuming a synbiotic containing Bifidobacterium bifidum, Bifidobacterium lactis, and oligofructose in elderly persons, determined by real-time polymerase chain reaction and counting of viable bacteria
    Sabine Bartosch
    Microbiology and Gut Biology Group, University of Dundee, Dundee, United Kingdom
    Clin Infect Dis 40:28-37. 2005
    ....
  18. pmc Endogenous interleukin-18 improves the early antimicrobial host response in severe melioidosis
    W Joost Wiersinga
    Academic Medical Center, Meibergdreef 9, Room G2 132, 1105 AZ Amsterdam, The Netherlands
    Infect Immun 75:3739-46. 2007
    ..Together, these data indicate that the enhanced production of IL-18 in melioidosis is an essential part of a protective immune response to this severe infection...
  19. pmc Fecal microbiota composition and frailty
    Sandra P van Tongeren
    Department of Medical Microbiology, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Appl Environ Microbiol 71:6438-42. 2005
    ..In contrast to this, the number of Enterobacteriaceae was significantly higher (sevenfold) in samples from very frail volunteers...
  20. ncbi Rapid detection of group B streptococci in pregnant women at delivery
    M G Bergeron
    Infectious Diseases Research Center and the Division of Microbiology, Universite Laval, Quebec, Que, Canada
    N Engl J Med 343:175-9. 2000
    ..Group B streptococcal infections are an important cause of neonatal morbidity and mortality. A rapid method for the detection of this organism in pregnant women at the time of delivery is needed to allow early treatment of neonates...
  21. pmc Transfer of vancomycin resistance transposon Tn1549 from Clostridium symbiosum to Enterococcus spp. in the gut of gnotobiotic mice
    Aline Launay
    Centre d Etudes Pharmaceutiques, Chatenay Malabry, France
    Antimicrob Agents Chemother 50:1054-62. 2006
    ..These data demonstrate functionality of the Tn1549-like element and attest that the transfer of the vanB operon between enterococci and human commensal anaerobes occurs in the intestinal environment...
  22. ncbi Enumeration of 16S rDNA of Desulfotomaculum lineage 1 in rice field soil by real-time PCR with SybrGreen detection
    Stephan Stubner
    Max Planck Institute for Terrestrial Microbiology, Karl von Frisch Strasse, D 35043, Marburg, Germany
    J Microbiol Methods 50:155-64. 2002
    ..Approximately half of this number was obtained in both habitats with a PCR assay specific for a Desulfotomaculum sequence cluster obtained previously from rice field soil...
  23. pmc Survival of enterococci and staphylococci on hospital fabrics and plastic
    A N Neely
    Shriners Hospitals for Children, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3095, USA
    J Clin Microbiol 38:724-6. 2000
    ....
  24. pmc Legionella contamination in hot water of Italian hotels
    Paola Borella
    Department of Hygiene and Microbiology, Via Campi, 287, I 41100 Modena, Italy
    Appl Environ Microbiol 71:5805-13. 2005
    ..pneumophila serogroup 1 colonization. The possible role of chlorine in favoring the survival of Legionella species is discussed...
  25. pmc The capacity of short-chain fructo-oligosaccharides to stimulate faecal bifidobacteria: a dose-response relationship study in healthy humans
    Yoram Bouhnik
    Hépato Gastroentérologie et Assistance Nutritive, Hopital Lariboisiere, 2 rue Ambroise Pare, 75475 Paris Cedex 10, France
    Nutr J 5:8. 2006
    ..5 to 10 g/d in comparison with a placebo. The aim of this presentation is to give more details about the dose-response effects of short-chain fructo-oligosaccharides (scFOS)...
  26. pmc Rectal carriage of enterohemorrhagic Escherichia coli O157 in slaughtered cattle
    J Christopher Low
    Animal Health Group, Scottish Agricultural College, UK
    Appl Environ Microbiol 71:93-7. 2005
    ..coli O157 carriage in cattle. The data also support the hypothesis that high-level fecal shedding (> or =1 x 10(3) CFU g of feces(-1)) of enterohemorrhagic E. coli O157 results from colonization of this site...
  27. ncbi Stability of microbial communities in goat milk during a lactation year: molecular approaches
    Cécile Callon
    INRA Unité de Recherches Fromagères URF545, INRA, 36 rue de Salers, 15000 Aurillac, France
    Syst Appl Microbiol 30:547-60. 2007
    ..However, the composition of the community can vary according to factors other than feeding. This study opens new investigation fields in the field of raw milk microbial ecology...
  28. ncbi Quantification of Bifidobacterium spp., Escherichia coli and Clostridium difficile in faecal samples of breast-fed and formula-fed infants by real-time PCR
    John Penders
    Department of Epidemiology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, 6200 MD Maastricht, The Netherlands
    FEMS Microbiol Lett 243:141-7. 2005
    ..difficile as well as E. coli are significantly lower in the gut microbiota of breast-fed infants than in that of formula-fed infants, whereas the prevalence and counts of Bifidobacterium spp. is similar among both groups...
  29. ncbi Hypermutability impedes cooperation in pathogenic bacteria
    Freya Harrison
    Department of Zoology, University of Oxford, United Kingdom
    Curr Biol 15:1968-71. 2005
    ..Cheats appeared and increased in frequency more rapidly in mutator populations. The presence of cheats was costly to the group, as shown by a negative correlation between cheat frequency and population density...
  30. ncbi Extracellular replication of Listeria monocytogenes in the murine gall bladder
    Jonathan Hardy
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 303:851-3. 2004
    ..The data suggest that L. monocytogenes may be carried in the human gall bladder...
  31. ncbi The rpf gene of Micrococcus luteus encodes an essential secreted growth factor
    Galina V Mukamolova
    Institute of Biological Sciences, University of Wales, Aberystwyth, Ceredigion SY23 3DD, UK
    Mol Microbiol 46:611-21. 2002
    ....
  32. ncbi Assessment of the microbial diversity at the surface of Livarot cheese using culture-dependent and independent approaches
    J Mounier
    UMR Genie et Microbiologie des Procedes Alimentaires, INRA, AgroParisTech, Thiverval Grignon, France
    Int J Food Microbiol 133:31-7. 2009
    ..These probes allowed the detection of these yeasts directly in cheese. The use of the rRNA gene-based approach combined with FISH analysis was useful to investigate the diversity of a surface microbial consortium from cheese...
  33. ncbi The effectiveness of existing and modified cleaning regimens in a Welsh hospital
    C J Griffith
    Cardiff School of Health Sciences, University of Wales Institute Cardiff, Cardiff, UK
    J Hosp Infect 66:352-9. 2007
    ..These findings suggest that simple improvements can be made to existing cleaning regimens to increase their efficacy...
  34. ncbi A novel titanium wound chamber for the study of wound infections in pigs
    Lars Steinstraesser
    Department for Plastic Surgery, Burn Center, BG University Hospital Bergmannsheil, Ruhr University, Bochum, Germany
    Comp Med 56:279-85. 2006
    ..We conclude that the use of titanium chambers in pigs provides a reliable and reproducible in vivo model to investigate wound healing, wound infection, and treatment options...
  35. ncbi Evaluation of the bacterial vaginal flora of 20 postmenopausal women by direct (Nugent score) and molecular (polymerase chain reaction and denaturing gradient gel electrophoresis) techniques
    Jeremy P Burton
    Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute, London, Ontario, Canada
    J Infect Dis 186:1770-80. 2002
    ..This study indicates that asymptomatic BV appears to be much more common than is currently perceived; these findings may have implications for the health of postmenopausal women...
  36. pmc Influence of pregnancy on the pathogenesis of listeriosis in mice inoculated intragastrically
    Terri S Hamrick
    College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
    Infect Immun 71:5202-9. 2003
    ....
  37. ncbi Persister cells and tolerance to antimicrobials
    Iris Keren
    Department of Biology, Northeastern University, Boston, MA 02115, USA
    FEMS Microbiol Lett 230:13-8. 2004
    ..This suggests that persisters are not at a particular stage in the cell cycle, neither are they defective cells nor cells created in response to antibiotics. Our data indicate that persisters are specialized survivor cells...
  38. ncbi The viable but nonculturable state in bacteria
    James D Oliver
    Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223 0001, USA
    J Microbiol 43:93-100. 2005
    ..It is hoped that this mini-review will encourage researchers to consider this survival state in their studies as an alternative to the conclusion that a lack of culturability indicates the cells they are examining are dead...
  39. ncbi Biofilm susceptibility to bacteriophage attack: the role of phage-borne polysaccharide depolymerase
    K A Hughes
    British Antarctic Survey, High Cross, Cambridge, UK
    Microbiology 144:3039-47. 1998
    ..Scanning electron microscopy confirmed that specific phage could extensively degrade susceptible biofilms and continue to infect biofilm bacteria whilst EPS degradation was occurring...
  40. ncbi CellProfiler: free, versatile software for automated biological image analysis
    Michael R Lamprecht
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Biotechniques 42:71-5. 2007
    ....
  41. pmc Phenotypic tolerance: antibiotic enrichment of noninherited resistance in bacterial populations
    C Wiuff
    Department of Biology, Emory University, 1510 Clifton Rd, Atlanta, Georgia 30322, USA
    Antimicrob Agents Chemother 49:1483-94. 2005
    ....
  42. ncbi The characterisation of Bacillus spores occurring in the manufacturing of (low acid) canned products
    S J C M Oomes
    Unilever Food and Health Reseach Institute, Department of Advanced Food Microbiology, Unilever Research and Development Vlaardingen, Olivier van Noortlaan 120, 3133AT Vlaardingen, The Netherlands
    Int J Food Microbiol 120:85-94. 2007
    ..The data proofed to be useful for the generation of strain specific probes. Protocols to validate these probes in routine identification and innovation aimed at tailor made heat processing in soup manufacturing have been formulated...
  43. ncbi Maternal adaptive immunity influences the intestinal microflora of suckling mice
    Rosa L Diaz
    Department of Pediatrics, Division of Gastroenterology and Nutrition, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, CA, USA
    J Nutr 134:2359-64. 2004
    ....
  44. ncbi Bacterial dynamics in spring water of alpine karst aquifers indicates the presence of stable autochthonous microbial endokarst communities
    Andreas H Farnleitner
    Institute of Chemical Engineering, Research Area Gene Technology and Applied Biochemistry, Vienna University of Technology, Getreidemarkt 166 9, A 1060 Vienna, Austria
    Environ Microbiol 7:1248-59. 2005
    ....
  45. ncbi Interactions in biofilms between Listeria monocytogenes and resident microorganisms from food industry premises
    Brigitte Carpentier
    Agence Francaise de Securite Sanitaire des Aliments, Laboratoire d Etudes et de Recherches sur la Qualité des Aliments et sur les Procédés Agro alimentaires, LERQAP, 23 avenue du Gnral De Gaulle, F 94706 Maisons Alfort, France
    Int J Food Microbiol 97:111-22. 2004
    ..monocytogenes cells adhering to the stainless steel coupons and forming microcolonies. This study suggests that the "house flora" can have a strong effect on the likelihood of finding L. monocytogenes on inert surfaces...
  46. pmc PCR-based DNA amplification and presumptive detection of Escherichia coli O157:H7 with an internal fluorogenic probe and the 5' nuclease (TaqMan) assay
    R D Oberst
    Food Animal Health and Management Center, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas 66506, USA
    Appl Environ Microbiol 64:3389-96. 1998
    ..coli O157:H7 in ground beef and potentially in other food and environmental samples...
  47. ncbi A toll-like receptor that prevents infection by uropathogenic bacteria
    Dekai Zhang
    Section of Immunobiology and Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 303:1522-6. 2004
    ..Mice lacking TLR11 are highly susceptible to infection of the kidneys by uropathogenic bacteria, indicating a potentially important role for TLR11 in preventing infection of internal organs of the urogenital system...
  48. ncbi Prospective, controlled, cross-over trial of alcohol-based hand gel in critical care units
    Mark E Rupp
    Department of Internal Medicine, University of Nebraska Medical Center, Omaha, USA
    Infect Control Hosp Epidemiol 29:8-15. 2008
    ..There are limited data from prospective studies to indicate whether improvement in hand hygiene associated with the use of alcohol-based hand hygiene products results in improved patient outcomes...
  49. ncbi Detection and quantification of the human-specific HF183 Bacteroides 16S rRNA genetic marker with real-time PCR for assessment of human faecal pollution in freshwater
    Sylvie Seurinck
    Laboratory of Microbial Ecology and Technology LabMET, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    Environ Microbiol 7:249-59. 2005
    ....
  50. ncbi Enumeration of heterotrophs, fecal coliforms and Escherichia coli in water: comparison of 3M Petrifilm plates with standard plating procedures
    H Schraft
    Department of Biology, Lakehead University, Thunder Bay, ON, Canada P7B 5E1
    J Microbiol Methods 60:335-42. 2005
    ..coli. This comparison illustrates the high specificity of Petrifilm EC plates for enumeration of both fecal coliforms and E. coli in water...
  51. pmc Effects of exogenous recombinant interleukin-12 on immune responses and protection against Brucella abortus in a murine model
    I K Lee
    Bacterial Diseases Research Unit, National Animal Disease Center, Agriculture Research Service, United States Department of Agriculture, Ames, Iowa 50010, USA
    Can J Vet Res 65:223-8. 2001
    ..05) S2308 colonization of splenic tissues. Our data suggest that although IL-12 may augment protective immunity induced by live SRB51, it does not influence protection induced by vaccination with killed SRB51...
  52. ncbi Presence of halophilic and alkaliphilic lactic acid bacteria in various cheeses
    M Ishikawa
    Department of Fermentation Science, Tokyo University of Agriculture, Tokyo, Japan
    Lett Appl Microbiol 44:308-13. 2007
    ..We sought to confirm the presence of halophilic and alkaliphilic lactic acid bacteria (HALAB) of marine origin in cheeses and thus contribute to the understanding of the roles of LAB flora in cheese ripening...
  53. ncbi A comparison of thiosulphate-citrate-bile salts-sucrose (TCBS) agar and thiosulphate-chloride-iodide (TCI) agar for the isolation of Vibrio species from estuarine environments
    C Pfeffer
    Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
    Lett Appl Microbiol 36:150-1. 2003
    ..The purpose of this study was to compare a recently described medium, thiosulphate-chloride-iodide (TCI), for the isolation of estuarine vibrios with thiosulphate-citrate-bile salts-sucrose (TCBS)...
  54. ncbi Microbiologic determinants of exacerbation in chronic obstructive pulmonary disease
    Antoni Rosell
    Servei de Pneumologia, Hospital Germans Trias i Pujol, 08916 Badalona, Spain
    Arch Intern Med 165:891-7. 2005
    ....
  55. ncbi Programmed population control by cell-cell communication and regulated killing
    Lingchong You
    Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA
    Nature 428:868-71. 2004
    ..This circuit incorporates a mechanism for programmed death in response to changes in the environment, and allows us to probe the design principles of its more complex natural counterparts...
  56. ncbi Antioxidative probiotic fermented goats' milk decreases oxidative stress-mediated atherogenicity in human subjects
    Tiiu Kullisaar
    Department of Biochemistry, Medical Faculty, University of Tartu, Tartu, Estonia
    Br J Nutr 90:449-56. 2003
    ..We conclude that the goats' milk fermented with our special antioxidative lactobacilli strain Lactobacillus fermentum ME-3 exhibits anti-atherogenic effects...
  57. ncbi Interleukin-18 gene-deficient mice show enhanced defense and reduced inflammation during pneumococcal meningitis
    Petra J G Zwijnenburg
    Department of Pediatrics, Vrije Universiteit Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    J Neuroimmunol 138:31-7. 2003
    ..These findings suggest that endogenous IL-18 contributes to a detrimental inflammatory response during pneumococcal meningitis and that elimination of IL-18 may improve the outcome of this disease...
  58. pmc Double blind, placebo controlled trial of two probiotic strains in interleukin 10 knockout mice and mechanistic link with cytokine balance
    J McCarthy
    Department of Medicine, University College Cork, National University of Ireland, Cork, Ireland
    Gut 52:975-80. 2003
    ..Prophylactic efficacy against colitis following lactobacillus consumption in interleukin 10 (IL-10) knockout (KO) mice has been reported. Whether this applies equally to other probiotic strains is unknown, and the mechanism is unclear...
  59. pmc Prolonged impact of antibiotics on intestinal microbial ecology and susceptibility to enteric Salmonella infection
    Amy Croswell
    Department of Pediatrics, Division of Gastroenterology, The Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Infect Immun 77:2741-53. 2009
    ....
  60. ncbi A family of autocrine growth factors in Mycobacterium tuberculosis
    Galina V Mukamolova
    Institute of Biological Sciences, University of Wales, Aberystwyth, Ceredigion SY23 3 DD, UK
    Mol Microbiol 46:623-35. 2002
    ..The Rpf family of bacterial growth factors may therefore provide novel opportunities for preventing and controlling mycobacterial infections...
  61. ncbi Influence of a combination of Lactobacillus acidophilus NCFM and lactitol on healthy elderly: intestinal and immune parameters
    Arthur C Ouwehand
    Health and Nutrition, Danisco, Sokeritehtaantie 20, 02460 Kantvik, Finland
    Br J Nutr 101:367-75. 2009
    ..The results suggest that consumption of lactitol combined with L. acidophilus NCFM twice daily may improve some markers of the intestinal microbiota composition and mucosal functions...
  62. pmc Discerning the complexity of community interactions using a Drosophila model of polymicrobial infections
    Christopher D Sibley
    Department of Microbiology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada
    PLoS Pathog 4:e1000184. 2008
    ..aeruginosa...
  63. pmc Experimental Mycobacterium tuberculosis infection of cynomolgus macaques closely resembles the various manifestations of human M. tuberculosis infection
    Saverio V Capuano
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Infect Immun 71:5831-44. 2003
    ..In addition, this model will provide an opportunity to study the latent M. tuberculosis infection observed in approximately 90% of all infected humans...
  64. ncbi Lactobacilli in the intestinal microbiota of Swedish infants
    Siv Ahrne
    Department of Food Technology, Engineering and Nutrition, Lund University, Box 124, 22100 Lund, Sweden
    Microbes Infect 7:1256-62. 2005
    ..Our results suggest that certain Lactobacillus species, especially L. rhamnosus, thrive in the intestinal flora of breast-fed infants. After weaning they are replaced by other Lactobacillus species of types found in food...
  65. pmc Novel endophytic nitrogen-fixing clostridia from the grass Miscanthus sinensis as revealed by terminal restriction fragment length polymorphism analysis
    Takuya Miyamoto
    Graduate School of Life Sciences, Tohoku University, Katahira, Aoba ku, Sendai, Japan
    Appl Environ Microbiol 70:6580-6. 2004
    ..When phylogenetic populations from M. sinensis and the soil around the plants were compared, group II clostridia were found to exist exclusively in M. sinensis...
  66. pmc The role of RelMtb-mediated adaptation to stationary phase in long-term persistence of Mycobacterium tuberculosis in mice
    John L Dahl
    Tuberculosis Research Section, National Institute of Allergy and Infectious Disease, 12441 Parklawn Drive, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 100:10026-31. 2003
    ..Thus, RelMtb is critical for the successful establishment of persistent infection in mice by altering the expression of antigenic and enzymatic factors that may contribute to successful latent infection...
  67. ncbi Dosage-related bifidogenic effects of galacto- and fructooligosaccharides in formula-fed term infants
    G Moro
    Center for Infant Nutrition, Macedonio Melloni Maternity Hospital, Milan, Italy
    J Pediatr Gastroenterol Nutr 34:291-5. 2002
    ..In this study, the bifidogenic effect of an experimental prebiotic oligosaccharide mixture consisting of low-molecular-weight galactooligosaccharides and high-molecular-weight fructooligosaccharides was analyzed in 90 term infants...
  68. ncbi Thermally treated grass fibers as colonizable substrate for beneficial bacterial inoculum
    R Trifonova
    Plant Research International, Wageningen, The Netherlands
    Microb Ecol 56:561-71. 2008
    ..4%) and alpha-proteobacteria (21.7%) were prevalent in TGF. A germination assay with lettuce seeds showed that the phytotoxicity of TGF and TGE decreased due to the microbial enrichment...
  69. ncbi Predictive model for survival and growth of Salmonella typhimurium DT104 on chicken skin during temperature abuse
    T P Oscar
    USDA, Agricultural Res Serv, Microbial Food Safety Research Unit and USDA 1890, Center for Food Science and Technol, Univ of Maryland Eastern Shore, Princess Anne, Maryland 21853, USA
    J Food Prot 72:304-14. 2009
    ..Thus, it was concluded that the tertiary model provided valid predictions for survival and growth of Salmonella Typhimurium DT104 from a low initial dose on both nonkosher and kosher chicken skin with native flora...
  70. pmc Charge effect on the photoinactivation of Gram-negative and Gram-positive bacteria by cationic meso-substituted porphyrins
    Eliana Alves
    Department of Biology and CESAM, University of Aveiro, 3810 193 Aveiro, Portugal
    BMC Microbiol 9:70. 2009
    ..The present study complements our previous work on the search for photosensitizers that might be considered good candidates for the photoinactivation of a large spectrum of environmental microorganisms...
  71. ncbi Quantification of biofilm in microtiter plates: overview of testing conditions and practical recommendations for assessment of biofilm production by staphylococci
    Srdjan Stepanovic
    Department of Bacteriology, Institute of Microbiology and Immunology, School of Medicine, Belgrade, Serbia
    APMIS 115:891-9. 2007
    ..The obtained results should simplify quantification of biofilm formation in microtiter plates, and make it more reliable and comparable among different laboratories...
  72. ncbi A modified ATP benchmark for evaluating the cleaning of some hospital environmental surfaces
    T Lewis
    University Hospitals Coventry and Warwickshire NHS Trust Hospital, Walsgrave, Coventry, UK
    J Hosp Infect 69:156-63. 2008
    ..They can also be used in the assessment of novel cleaning methods, such as steam cleaning and microfibre cloths, which have potential use in the National Health Service...
  73. ncbi Porphyrin derivatives as photosensitizers for the inactivation of Bacillus cereus endospores
    A Oliveira
    Department of Biology and CESAM, University of Aveiro, Aveiro, Portugal
    J Appl Microbiol 106:1986-95. 2009
    ....
  74. ncbi Control of bacterial contamination in microfiltered water dispensers (MWDs) by disinfection
    Franca Zanetti
    Department of Medicine and Public Health, University of Bologna, Via S Giacomo, 12 40126 Bologna, Italy
    Int J Food Microbiol 128:446-52. 2009
    ..In conclusion, hydrogen peroxide at 3% can be proposed as a suitable product for periodic disinfection of domestic MWDs, taking into consideration also its low cost and easy availability...
  75. ncbi Italian multicentre study on microbial environmental contamination in dental clinics: a pilot study
    Cesira Pasquarella
    Dipartimento di Sanita Pubblica, Universita degli Studi di Parma, Italy
    Sci Total Environ 408:4045-51. 2010
    ....
  76. ncbi Cultivation of globally distributed soil bacteria from phylogenetic lineages previously only detected in cultivation-independent surveys
    Michelle Sait
    Department of Microbiology and Immunology, The University of Melbourne, Victoria 3010, Australia
    Environ Microbiol 4:654-66. 2002
    ....
  77. pmc Modeling microbial survival in buildup biofilm for complex medical devices
    Michelle J Alfa
    Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada
    BMC Infect Dis 9:56. 2009
    ..This study investigated whether the BBF matrix represents a greater challenge to disinfectant efficacy and microbial eradication than traditional biofilm (TBF), which forms when a surface is constantly bathed in fluid...
  78. ncbi Potential for preventing spread of fungi in air-conditioning systems constructed using copper instead of aluminium
    L Weaver
    Environmental Healthcare Unit, University of Southampton, Biomedical Sciences Building, Bassett Crescent East, Southampton, UK
    Lett Appl Microbiol 50:18-23. 2010
    ..As copper has been previously suggested as an antimicrobial surface, we tested the effectiveness of copper as an antifungal surface which could be used in air-conditioning systems as an alternative to aluminium...
  79. pmc Quantitative real-time PCR assays to identify and quantify fecal Bifidobacterium species in infants receiving a prebiotic infant formula
    Monique Haarman
    Microbiology Section, Biomedical Research Department, Numico Research BV, P O Box 7005, 6700 CA Wageningen, The Netherlands
    Appl Environ Microbiol 71:2318-24. 2005
    ..38% +/- 0.98% for the OSF group). In conclusion, the specific prebiotic infant formula used induces a fecal microbiota that closely resembles the microbiota of breast-fed infants also at the level of the different Bifidobacterium species...
  80. ncbi Wound fluid bacterial levels exceed tissue bacterial counts in controlled porcine partial-thickness burn infections
    Karl Breuing
    Division of Plastic Surgery, Brigham and Women s Hospital and Children s Hospital, Boston, Mass 02115, USA
    Plast Reconstr Surg 111:781-8. 2003
    ....
  81. ncbi Development and validation of a stochastic model for predicting the growth of Salmonella typhimurium DT104 from a low initial density on chicken frankfurters with native microflora
    T P Oscar
    U S Department of Agriculture, Agricultural Research Service, Microbial Food Safety Research Unit, Maryland 21853, USA
    J Food Prot 71:1135-44. 2008
    ..Based on this performance evaluation, the tertiary model was considered acceptable and valid for stochastic predictions of Salmonella Typhimurium DT104 growth from a low initial density on chicken frankfurters with native microflora...
  82. ncbi Origin and spoilage potential of the microbiota dominating genus Psychrobacter in sterile rehydrated salt-cured and dried salt-cured cod (Gadus morhua)
    Ingebrigt Bjørkevoll
    Norwegian Institute of Fisheries and Aquaculture Research, N 9291 Tromsø, Norway
    Int J Food Microbiol 84:175-87. 2003
    ..The dominating bacterium in rehydrated salt-cured and dried salt-cured cod seems to mainly originate from the fresh fish itself and not from contamination during processing...
  83. ncbi Effect of brining, modified atmosphere packaging, and superchilling on the shelf life of Cod (Gadus morhua) loins
    Hélène L Lauzon
    Matis ohf, 101 Reykjavik, Iceland
    J Food Sci 74:M258-67. 2009
    ..The shelf life of air-packed brined loins at -2 degrees C was 12 to 15 d but only 13 d under MA. The same synergistic effect did therefore not apply to brined loins as with unbrined ones...
  84. pmc Impact of immunization against SpyCEP during invasive disease with two streptococcal species: Streptococcus pyogenes and Streptococcus equi
    Claire E Turner
    Department of Infectious Diseases and Immunity, Hammersmith Hospital, Du Cane Road, London, W12 0NN, United Kingdom
    Vaccine 27:4923-9. 2009
    ..CEP-immunized mice also demonstrated reduced bacterial dissemination from S. equi intramuscular infection. Therefore immunization against SpyCEP may provide protection against other streptococci species with homologous proteases...
  85. ncbi Control of Pseudomonas aeruginosa and Stenotrophomonas maltophilia contamination of microfiltered water dispensers with peracetic acid and hydrogen peroxide
    Rossella Sacchetti
    Department of Medicine and Public Health, Division of Hygiene, University of Bologna, Via S Giacomo, 12 40126 Bologna, Italy
    Int J Food Microbiol 132:162-6. 2009
    ..In the case of disinfection with HP for 40 min, P. aeruginosa was not detected in most of the samples (73.7%). Numbers of S. maltophilia decreased with increasing time after treatment...
  86. pmc Airway inflammation and bronchial bacterial colonization in chronic obstructive pulmonary disease
    Sanjay Sethi
    Division of Pulmonary Critical Care and Sleep Medicine, and Division of Infectious Diseases, Department of Medicine, University at Buffalo, Buffalo, NY, USA
    Am J Respir Crit Care Med 173:991-8. 2006
    ..This "colonization" of the tracheobronchial tree, currently believed to be innocuous, could serve as an inflammatory stimulus, independent of current tobacco smoke exposure...
  87. ncbi [Occurrence of bacteria from the Legionella genus in cooling water systems]
    Renata Matuszewska
    Zakład Higieny Komunalnej, Narodowy Instytut Zdrowia Publicznego Państwowy Zakład Higieny, 00 791 Warszawa, ul Chocimska 24
    Rocz Panstw Zakl Hig 59:445-54. 2008
    ..Creation of low regulations which will put the obligation of cooling water systems monitoring of Legionella bacteria occurrence and taking preventive measures is necessary...
  88. ncbi Evaluation of logistic processing to reduce cross-contamination of commercial broiler carcasses with Campylobacter spp
    Lakshmi Prasanna Potturi-Venkata
    Department of Poultry Science, Auburn University, Auburn, Alabama 36849 5416, USA
    J Food Prot 70:2549-54. 2007
    ..These findings suggest that a simple logistic processing schedule can preserve the Campylobacter-negative status of broiler carcasses and result in products with enhanced food safety...
  89. ncbi Survival of Clostridium difficile on copper and steel: futuristic options for hospital hygiene
    L Weaver
    Environmental Healthcare Unit, School of Biological Sciences, University of Southampton, Southampton, UK
    J Hosp Infect 68:145-51. 2008
    ..The results suggest that using copper alloys in hospitals and other healthcare facilities could offer the potential to reduce spread of C. difficile from contaminated surfaces...
  90. ncbi Bacterial community dynamics during the winter-spring transition in the North Sea
    Melanie Sapp
    Alfred Wegnener Institute, Foundation for Polar and Marine Research, Biologische Anstalt Helgoland, Helgoland, Germany
    FEMS Microbiol Ecol 59:622-37. 2007
    ..Overall, results indicate that changes in the bacterial community were caused not only by abiotic factors but also by the phytoplankton community...
  91. ncbi Character displacement promotes cooperation in bacterial biofilms
    Michael A Brockhurst
    School of Biological Sciences, Biosciences Building, University of Liverpool, Crown Street, Liverpool L69 7ZB, United Kingdom
    Curr Biol 16:2030-4. 2006
    ..These results demonstrate that diversification into different ecological niches can minimize selection against cooperation in the face of local resource competition...
  92. ncbi Transfer coefficient models for escherichia coli O157:H7 on contacts between beef tissue and high-density polyethylene surfaces
    Rolando A Flores
    Crop Conversion Science and Engineering Research Unit, U S Department of Agriculture, Agricultural Research Service, Eastern Regional Research Center, 600 East Mermaid Lane, Wyndmoor, Pennsylvania 19038, USA
    J Food Prot 69:1248-55. 2006
    ..The parameters for the exponential model for cross-contamination with E. coli O157:H7 between beef tissue and HDPE surfaces were determined, allowing for the use of the resulting model in quantitative microbial risk assessment...
  93. pmc Serotypes, virulence genes and intimin types of Shiga toxin (verocytotoxin)-producing Escherichia coli isolates from minced beef in Lugo (Spain) from 1995 through 2003
    Azucena Mora
    Laboratorio de Referencia de E coli, Departamento de Microbioloxia e Parasitoloxia, Universidade de Santiago de Compostela USC, 27002 Lugo, Spain
    BMC Microbiol 7:13. 2007
    ..Also to establish if those STEC isolated from food possessed the same virulence profiles as STEC strains causing human infections...
  94. ncbi Lactobacillus salivarius CECT 5713, a potential probiotic strain isolated from infant feces and breast milk of a mother-child pair
    R Martin
    Departamento de Nutricion, Bromatologia y Tecnologia de los Alimentos, Facultad de Veterinaria, Universidad Complutense de Madrid, 28040 Madrid, Spain
    Int J Food Microbiol 112:35-43. 2006
    ..Finally, it was strongly adhesive to Caco-2 and HT-29 cells did not produce biogenic amines and were unable to degrade gastric mucin in vitro...
  95. ncbi Bacteriological quality of drinking water from dispensers (coolers) and possible control measures
    Andreas Baumgartner
    Federal Office of Public Health, Section of Microbiology and Biotechnology, 3003 Bern, Switzerland
    J Food Prot 69:3043-6. 2006
    ..Consequently, in keeping with legal requirement for bottled spring and mineral water in Switzerland, it is also advisable that P. aeruginosa be absent in 100-ml samples of cooler water...
  96. ncbi Growth and lysis of the fish pathogen Moritella viscosa
    E Benediktsdottir
    Institute of Biology, University of Iceland, Askja, Iceland
    Lett Appl Microbiol 45:115-20. 2007
    ..The sensitivity to lysis is a profound bottleneck to studies of the fish pathogen Moritella viscosa. The aim of this study was to examine the growth and the lysis process of M. viscosa cells under different physical and chemical conditions...
  97. ncbi Risk Factors for Methicillin-Resistant Staphylococcus aureus (MRSA) and Use of a Nasal Mupirocin Ointment in Oral Cancer Inpatients
    Minoru Miyake
    Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Kagawa University, Kagawa, Japan
    J Oral Maxillofac Surg 65:2159-63. 2007
    ..Elimination of methicillin-resistant Staphylococcus aureus (MRSA) is of critical importance in oral and maxillofacial surgery because control is very difficult once infection of an oral tumor or oral wound with MRSA is established...
  98. ncbi Biofilm-forming ability profiling of Staphylococcus aureus and Staphylococcus epidermidis mastitis isolates
    M Oliveira
    CIISA Faculdade de Medicina Veterinaria, Avenida da Universidade Tecnica, 1300 477 Lisboa, Portugal
    Vet Microbiol 118:133-40. 2006
    ..This method better mimics the in vivo conditions, especially in terms of the presence of calcium and iron, which in high concentrations, respectively, are known to inhibit or induce biofilm production...
  99. ncbi Inactivation of Pseudomonas aeruginosa and Aeromonas hydrophila by silver in tap water
    Nadia Silvestry-Rodriguez
    Department of Agricultural and Biosystems Engineering, The University of Arizona, Tucson, Arizona, USA
    J Environ Sci Health A Tox Hazard Subst Environ Eng 42:1579-84. 2007
    ..Furthermore, silver shows promise as a secondary disinfectant, even in the presence of organic matter in concentrations that would reduce the effectiveness of free chlorine...
  100. ncbi Inflammation patterns induced by different Burkholderia species in mice
    W Joost Wiersinga
    Center for Infection and Immunity Amsterdam CINIMA, Amsterdam, The Netherlands
    Cell Microbiol 10:81-7. 2008
    ..pseudomallei 1026b or AJ1D8. These data show that B. pseudomallei AJ1D8 is just as lethal as wild-type B. pseudomallei in an in vivo mouse model, and B. thailandensis is perhaps more virulent than is often recognized...
  101. ncbi Potential use of copper surfaces to reduce survival of epidemic meticillin-resistant Staphylococcus aureus in the healthcare environment
    J O Noyce
    Environmental Healthcare Unit, University of Southampton, Southampton, UK
    J Hosp Infect 63:289-97. 2006
    ..Consequently, the contemporary application of stainless steel in hospital environments for work surfaces and door furniture is not recommended...

Research Grants63

  1. Development of a HTS system:topoisomerase targets (RMI)
    Yuk Ching Tse Dinh; Fiscal Year: 2004
    ..The screening system should also be applicable for targeting topoisomerases in pathogenic bacteria relevant for biodefense. ..
  2. Duodenal Mucosal Defense Mechanisms
    Jonathan D Kaunitz; Fiscal Year: 2013
    ..Since Duox is hypothesized to control foregut bacterial colonization, the proposed system may bear on several important diseases, such as small intestinal bacteria overgrowth (SIBO), cystic fibrosis, and inflammatory bowel disease. ..
  3. The effectiveness of copper surfaces in reducing healthcare acquired infections
    DANIEL ZACHARY USLAN; Fiscal Year: 2013
    ..This project therefore addresses the recent focus of AHRQ on novel approaches to prevention and reduction of healthcare-associated infections. ..
  4. ERADICATING BIOFILMS WITH AN ATMOSPHERIC GLOW PLASMA
    Kimberly Kelly Wintenberg; Fiscal Year: 2000
    ..The technology is relatively inexpensive and can be engineered to fit on a tabletop or to be portable. Such a device would find great use in hospitals, clinics, physican and dental offices, to name a few. ..
  5. An in vivo Gene Deletion System for Analyzing Temporal Requirement of the Dot/Icm
    Zhao Qing Luo; Fiscal Year: 2009
    ..In addition, study on this bacterium could share light on our understanding of other intracellular pathogens because L. pneumophila and these infectious agents share many pathogenic mechanisms. ..
  6. Novel Polymer Coatings for Prevention of Biofilms in Dental Unit Waterlines
    Jeffrey Dalsin; Fiscal Year: 2009
    ..Coatings for waterlines that are designed to prevent bacterial growth would largely prevent this problem, reducing health-related risks to both patients and Dental care workers. ..
  7. DETECTION OF DENTAL WATER LINE BIOFILMS
    Thomas Rogers; Fiscal Year: 2000
    ..Development of a rapid, automated system that can be integrated into biocide control processes would be of enormous value in dealing with these multibillion dollar problems. ..
  8. RAPID SCREENING OF MICROBES IN URINE
    WAI CHUN LO; Fiscal Year: 2000
    ..Reagent systems which will distinguish bacteria from other urine sediment elements have high potential as products. 60,000,000 annual urine microbiology cultures are performed in North America. ..
  9. Novel Targets for Treatment of Pseudomonas aeruginosa
    Philip Lister; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  10. MICROBIAL ASSOCIATIONS IN PERIODONTAL HEALTH AND DISEASE
    Anne Haffajee; Fiscal Year: 2006
    ..These data will provide a basis for understanding microbial community structure, ecological relationships and define desired microbiological end-point of therapy. ..
  11. Identification of Uncultivated and Unrecognized Pathogens of Periodontitis
    ANNE DENISE HAFFAJEE; Fiscal Year: 2010
    ..The identification of such pathogens should, over time, lead to better diagnosis of disease, optimal treatment strategies for the individual patient, new therapeutic approaches and carefully targeted approaches to prevention. ..
  12. Three Periodontal Therapies in Current & Non-Smokers
    Anne Haffajee; Fiscal Year: 2007
    ..The proposed investigation should provide a model to examine methods that could be useful in treating compromised patients whether compromised by harmful habits such as smoking, systemic disease, or genetic background. ..
  13. EFFECT OF ANTIBIOTICS ON ORAL BIOFILMS IN VIVO
    Anne Haffajee; Fiscal Year: 2001
    ..abstract_text> ..
  14. C. difficile Toxin Membrane Test with Magnetic Particles
    ROBERT CARMAN; Fiscal Year: 2004
    ..perfringens enterotoxin, another cause of AAD. The technology developed in this project will be widely applicable for the development of new highly sensitive stool antigen tests. ..
  15. Mucin-degrading microflora for prophylactic antibiotics
    ROBERT CARMAN; Fiscal Year: 2008
    ..difficile, and reduces the incidence of C. difficile- induced antibiotic-associated diarrhea. [unreadable] [unreadable] [unreadable]..
  16. Chronic Prostatitis Collaborative Research Network
    Anthony Schaeffer; Fiscal Year: 2007
    ..abstract_text> ..
  17. Novel Application of Infection Control Strategies to Limit Transmission of ESBL'S
    Ebbing Lautenbach; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  18. QUINOLONE RESISTANCE IN NOSOCOMIAL URINARY INFECTIONS
    Ebbing Lautenbach; Fiscal Year: 2004
    ....
  19. Clinical Impact of Quinolone-Resistant E.coli carriage
    Ebbing Lautenbach; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  20. Quinolone resistant E coli in long term care facilities
    Ebbing Lautenbach; Fiscal Year: 2009
    ..abstract_text> ..
  21. Novel Antimicrobial Agents Against M. tuberculosis
    MARCUS HORWITZ; Fiscal Year: 2008
    ..mammalian GS, and test the toxicity of the analogs in mice. 2) Test the novel MSO analogs for their capacity to inhibit M. tuberculosis growth in broth culture, in human macrophages, and in guinea pigs. ..
  22. Quantitative PCR for the Detection of Fungal Infections
    David Fredricks; Fiscal Year: 2008
    ..Hypothesis: Fungal 18S rDNA qPCR employing a broad range fungal probe, or a system of multiple specific probes, will be useful for detecting emerging fungal pathogens in the transplant setting. [unreadable] [unreadable]..
  23. Innate Effectors of rAls3p-N Anti-Candida Vaccine
    Brad J Spellberg; Fiscal Year: 2010
    ..PNS 398/2590 (Rev. 11/07) Page - Continuation Format Page ..
  24. Adrenergic Antagonism During Murine Candidiasis
    Brad Spellberg; Fiscal Year: 2008
    ..For these reasons, the potential for adrenergic antagonism to act as an effective immunotherapy is highly meritorious of investigation in this training application. ..
  25. Effectiveness of Sealing Caries: A Way to Reduce Disparities in Dental Caries
    Margherita Fontana; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  26. Cellular & Molecular Fungal Biology 2008 Gordon Research Conference
    Nancy Keller; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  27. LcrV Plague Vaccine with Altered Immune Modulatory Properties
    Olaf Schneewind; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  28. Attachment of Oral Actinobacillus to Epithelium
    Daniel Fine; Fiscal Year: 2008
    ..The longterm goal of this application is to use this information to identify targets for therapeutic agents that can interfere with attachment of Aa to oral tissues and thus prevent colonization leading to LAP. [unreadable] [unreadable]..
  29. Tularemia and the Human Innate Immune Response
    Gary Klimpel; Fiscal Year: 2009
    ..abstract_text> ..
  30. Human Cellular Immune Responses to Leptospira
    Gary Klimpel; Fiscal Year: 2009
    ..Learning how Leptospira interact with the human immune system will lead us to understand the pathogenesis of leptospirosis and how to develop vaccines and strategies to control the associated pathology. ..
  31. Interdisciplinary Research:Antimicrobial Resistance(RMI)
    Elaine Larson; Fiscal Year: 2006
    ..In the final year, plans for a sustainable Consortium on antimicrobial resistance will be formalized. [unreadable] [unreadable]..
  32. Regulation of Pulmonary Host Defense by Leptin
    Peter Mancuso; Fiscal Year: 2010
    ..They will also test the use of exogenous leptin as an adjunctive therapeutic agent in the treatment of pneumococcal pneumonia. ..
  33. The Pore-forming Toxin of Legionella Pneumophila
    Yousef Abu Kwaik; Fiscal Year: 2003
    ..Our studies on L. pneumophila may provide a paradigm for other vacuolar intracellular pathogens such as Mycobacterium, Salmonella, and Chlamydia. ..
  34. Recombinant murine IL-10 produced in situ by H. pylori
    KATHRYN EATON; Fiscal Year: 2005
    ..pylori, but will also establish a model in which the roles of other cytokines and mediators can be determined, and host and bacterial interactions can be directly evaluated in vivo. ..
  35. M TUBERCULOSIS PHAGOSOME
    MARCUS HORWITZ; Fiscal Year: 2002
    ..tuberculosis to survive and multiply within its host cells and should facilitate the development of new strategies for prevention and treatment of tuberculosis. ..
  36. Oral Immunology/Microbiology Research Group Annual Mtg
    Daniel Fine; Fiscal Year: 2003
    ..Perpetuation of the OIMRG and its annual meetings greatly enhances the spirit of collegial interaction/collaboration among investigators with expertise in immunology and microbial pathogenesis as related to oral health and disease. ..
  37. Characterization of the Francisella tularensis phagosome
    MARCUS HORWITZ; Fiscal Year: 2003
    ..tularensis subverts the host cell membrane trafficking pathways and attains an intracellular compartment that is hospitable for its survival and growth will help guide new strategies for the prevention and treatment of tularemia. ..
  38. Toll-like Receptors and the Innate Immune Response
    THOMAS HAWN; Fiscal Year: 2003
    ..tuberculosis and L. major will reveal novel insights about innate immunity and infectious diseases that will have implications for vaccine development. ..
  39. BACTERIAL MODULATION OF LUNG INFLAMMATORY RESPONSE
    Thomas Russo; Fiscal Year: 2004
    ..g. hemolysin) and bacterially induced host response elements in directly mediating the pathogenesis of lung injury. ..
  40. HOME HYGIENE INTERVENTION
    Elaine Larson; Fiscal Year: 2002
    ..Logistic regression, Liang-Zeger regression, and Chi Square analyses will be used to test differences in rates of transmission of symptoms and changes in quantity, types and resistance patterns of microbial flora of the hands. ..
  41. SORBENTS+ENGINEERED BACTERIA AS GUT-BASED UREMIA THERAPY
    Natarajan Ranganathan; Fiscal Year: 2002
    ..It is equally feasible that our oral formulation may also have applications as a adjunct therapy for dialysis. ..
  42. Microbial Markers for Periodontal Disease in Children
    Daniel Fine; Fiscal Year: 2005
    ....
  43. Oral infection and inflammation in transplant patients
    Anna Dongari Bagtzoglou; Fiscal Year: 2005
    ....
  44. Periodontal Disease and Prematurity
    Ananda Dasanayake; Fiscal Year: 2006
    ..The collective expertise of the investigative team and the excellent clinical and research facilities are additional strengths. ..
  45. Tracking Mucosal T cells to Commensal Microbes in Vivo
    Massimo Costalonga; Fiscal Year: 2006
    ..The data will be important to human health, establishing a framework to study in vivo mucosal infectious agents and oral vaccines. ..
  46. Predicting Caries Risk in Underserved Toddlers
    Margherita Fontana; Fiscal Year: 2005
    ....
  47. PCR assays to detect individual pneumococcal serotypes
    LORRY RUBIN; Fiscal Year: 2006
    ..Furthermore, they will be critical for determining the effects of current and future pneumococcal vaccines on serotype-specific carriage. ..
  48. Host and Bacterial Factors in Disease due to H. pylori
    Kathryn A Eaton; Fiscal Year: 2010
    ..This will allow us to hire additional staff to ensure rapid completion of the remaining experiments. With these changes we fully expect to complete these experiments in 2 years. ..
  49. Oral Exposure and Transmission of HIV
    Peter Southern; Fiscal Year: 2003
    ....
  50. Role of Cytokines in Two Hit Organ Injury
    Jean Nemzek; Fiscal Year: 2006
    ..Successful completion of these aims could impact current two hit theories and use of immune therapy in septic patients exposed to additional inflammatory insults. ..
  51. P. Aeruginosa Biofilms and Burn Wound Infections
    Karin Sauer; Fiscal Year: 2006
    ..aeruginosa pathogenesis and by identifying virulence factors that may be targeted for therapeutic intervention. ..
  52. The Molecular Microbiology of Bacterial Vaginosis
    David Fredricks; Fiscal Year: 2003
    ..In future studies, vaginal fluid samples from a larger cohort of women will be assayed to determine if a candidate pathogen is specifically associated with BV. ..
  53. A dietary supplement for augmenting kidney function
    Natarajan Ranganathan; Fiscal Year: 2004
    ..The fully developed product will have immense benefits for the uremic patients both in a higher quality of life and a decrease in the financial burden associated with renal dysfunction therapy. ..
  54. Incidence, risk factors, and consequences of neonatal hypothermia in Nepal
    LUKE MULLANY; Fiscal Year: 2008
    ..Examination of alternate cutoffs for defining hypothermia severity may improve design of low-cost technologies for identification and subsequent management of hypothermic infants in the community. [unreadable] [unreadable] [unreadable]..
  55. Microbiology of Stenotrophomonas maltophilia infection
    JOANNA BROOKE; Fiscal Year: 2005
    ..abstract_text> ..
  56. The Type III Pathway of Yersinia Pestis
    Olaf Schneewind; Fiscal Year: 2004
    ..Together these studies are also aimed at identifying molecular targets for drug therapies, an important area of research to aid in the defense against biological warfare and bioterrorist deployment of the select agent Y. pestis. ..
  57. OmpR and acid regulation of Escherichia coli fim genes
    WILLIAM SCHWAN; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  58. Oral Immunology/Microbiology Annual Meeting
    Daniel Fine; Fiscal Year: 2003
    ..Perpetuation of the OIMRG and its annual meetings greatly enhances the spirit of collegial interaction/collaboration among investigators with expertise in immunology and microbial pathogenesis as related to oral health and disease. ..
  59. Receptor-Mediated Endocytosis of Legionella Pneumophila
    Yousef Abu Kwaik; Fiscal Year: 2004
    ..Our studies may uncover potential pathogenic evolution of Lpn to invade the more evolved mammalian cells, and may contribute to the understanding of invasion of protozoa by Mycobacterium and Chlamydia. ..
  60. Social Ordering and Mental/Physical Health in Children
    W Boyce; Fiscal Year: 2006
    ..abstract_text> ..
  61. Social Disparities in the Early Neurobiology of Stress
    W Boyce; Fiscal Year: 2006
    ..abstract_text> ..
  62. Impact of Social Stress on TLR4-Induced Microbicidal Activity of CD11b+ Cells
    Michael Bailey; Fiscal Year: 2008
    ..Defining the stress-induced cellular changes that enhance immune functioning could stimulate new therapeutic approaches to treating infectious diseases. [unreadable] [unreadable] [unreadable] [unreadable]..