cytological techniques

Summary

Top Publications

  1. ncbi Cervical biopsy-based comparison of a new liquid-based thin-layer preparation with conventional Pap smears
    Maria da Gloria Mattosinho de Castro Ferraz
    Department of Gynecology, Federal University of Sao Paulo, Escola Paulista de Medicina Unifesp EPM, Sao Paulo, Brazil
    Diagn Cytopathol 30:220-6. 2004
  2. ncbi Direct comparison of liquid-based and conventional cytology in a South African screening trial
    Sylvia Taylor
    Department of Pathology, Columbia University, New York, NY 10032, USA
    Int J Cancer 118:957-62. 2006
  3. ncbi A comparison of liquid-based cytology with conventional cytology
    C Celik
    Department of Obstetrics and Gynecology, Selcuk University Meram Medical School, Konya, Turkey
    Int J Gynaecol Obstet 100:163-6. 2008
  4. pmc Long term predictive values of cytology and human papillomavirus testing in cervical cancer screening: joint European cohort study
    Joakim Dillner
    Lund University, Medical Microbiology, University Hospital MAS, 205 02 Malmo, Sweden
    BMJ 337:a1754. 2008
  5. pmc Aptamer-based microfluidic device for enrichment, sorting, and detection of multiple cancer cells
    Ye Xu
    Center for Research at the Bio Nano Interface, Department of Chemistry, Shands Cancer Center, UF Genetics Institute, University of Florida, Gainesville, Florida 32611 7200, USA
    Anal Chem 81:7436-42. 2009
  6. ncbi HPV screening for cervical cancer in rural India
    Rengaswamy Sankaranarayanan
    International Agency for Research on Cancer, Lyon, France
    N Engl J Med 360:1385-94. 2009
  7. pmc HPV testing in routine cervical screening: cross sectional data from the ARTISTIC trial
    H C Kitchener
    Division of Human Development, University of Manchester, Hathersage Road, Manchester M13 0JH, UK
    Br J Cancer 95:56-61. 2006
  8. pmc Intravital microscopy: a novel tool to study cell biology in living animals
    Roberto Weigert
    Intracellular Membrane Trafficking Unit, Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive Room 303A, Bethesda, MD 20892 4340, USA
    Histochem Cell Biol 133:481-91. 2010
  9. ncbi Human papillomavirus viral load expressed as relative light units (RLU) correlates with the presence and grade of preneoplastic lesions of the uterine cervix in atypical squamous cells of undetermined significance (ASCUS) cytology
    M Origoni
    Department of Obstetrics and Gynecology, Vita Salute San Raffaele University School of Medicine at San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy
    Eur J Clin Microbiol Infect Dis 31:2401-6. 2012
  10. pmc Take advantage of time in your experiments: a guide to simple, informative kinetics assays
    Thomas D Pollard
    Department of Molecular Cellular and Developmental Biology, Yale University, New Haven, CT 06520 8103, USA
    Mol Biol Cell 24:1103-10. 2013

Research Grants

  1. STRUCTURE AND GENETIC CONTROL OF COLICINES
    Donald Helinski; Fiscal Year: 2005
  2. Recombination pathway and partner choice during C. elegans meiosis
    DIANA ELIZABETH LIBUDA; Fiscal Year: 2013
  3. The Role of IME4 and IME2 in Drosophila Gametogenesis
    CINTIA FABIANA HONGAY; Fiscal Year: 2010
  4. NEURONAL DEVELOPMENT INTERACTION AND ORGANIZATION
    Michael Bennett; Fiscal Year: 2000
  5. GENETIC ANALYSIS OF ENDOCYTOSIS
    Monty Krieger; Fiscal Year: 1990
  6. Endoscopic Therapy of Early Cancer in Barretts Esophagus
    Kenneth Wang; Fiscal Year: 2009
  7. ROLE OF PROTO-ONCOGENES IN THE DEVELOPMENT OF C. ELEGANS
    Mario Capecchi; Fiscal Year: 1990
  8. ToxR and TcpP function and localization in V. cholerae
    JYL MATSON; Fiscal Year: 2007
  9. CHEMISTRY & MORPHOLOGY OF VITREOUS REGENERATION
    ERWIN HULTSCH; Fiscal Year: 1980
  10. REGULATION OF CELLULAR PROLIFERATION
    Michael Prystowsky; Fiscal Year: 1991

Detail Information

Publications228 found, 100 shown here

  1. ncbi Cervical biopsy-based comparison of a new liquid-based thin-layer preparation with conventional Pap smears
    Maria da Gloria Mattosinho de Castro Ferraz
    Department of Gynecology, Federal University of Sao Paulo, Escola Paulista de Medicina Unifesp EPM, Sao Paulo, Brazil
    Diagn Cytopathol 30:220-6. 2004
    ....
  2. ncbi Direct comparison of liquid-based and conventional cytology in a South African screening trial
    Sylvia Taylor
    Department of Pathology, Columbia University, New York, NY 10032, USA
    Int J Cancer 118:957-62. 2006
    ..Because of the higher unit cost of LBC, low resource settings should carefully consider the potential benefits and drawbacks of LBC before adopting this new technology...
  3. ncbi A comparison of liquid-based cytology with conventional cytology
    C Celik
    Department of Obstetrics and Gynecology, Selcuk University Meram Medical School, Konya, Turkey
    Int J Gynaecol Obstet 100:163-6. 2008
    ..To evaluate the 2 methods of cytologic screening to detect abnormalities of the cervical epithelium...
  4. pmc Long term predictive values of cytology and human papillomavirus testing in cervical cancer screening: joint European cohort study
    Joakim Dillner
    Lund University, Medical Microbiology, University Hospital MAS, 205 02 Malmo, Sweden
    BMJ 337:a1754. 2008
    ..To obtain large scale and generalisable data on the long term predictive value of cytology and human papillomavirus (HPV) testing for development of cervical intraepithelial neoplasia grade 3 or cancer (CIN3+)...
  5. pmc Aptamer-based microfluidic device for enrichment, sorting, and detection of multiple cancer cells
    Ye Xu
    Center for Research at the Bio Nano Interface, Department of Chemistry, Shands Cancer Center, UF Genetics Institute, University of Florida, Gainesville, Florida 32611 7200, USA
    Anal Chem 81:7436-42. 2009
    ....
  6. ncbi HPV screening for cervical cancer in rural India
    Rengaswamy Sankaranarayanan
    International Agency for Research on Cancer, Lyon, France
    N Engl J Med 360:1385-94. 2009
    ....
  7. pmc HPV testing in routine cervical screening: cross sectional data from the ARTISTIC trial
    H C Kitchener
    Division of Human Development, University of Manchester, Hathersage Road, Manchester M13 0JH, UK
    Br J Cancer 95:56-61. 2006
    ..HPV 16 and HPV 18 are more predictive of underlying disease, but other HPV types account for 30% of high-grade disease...
  8. pmc Intravital microscopy: a novel tool to study cell biology in living animals
    Roberto Weigert
    Intracellular Membrane Trafficking Unit, Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive Room 303A, Bethesda, MD 20892 4340, USA
    Histochem Cell Biol 133:481-91. 2010
    ..Indeed, first we will focus on those studies in which organs were imaged at the tissue level, then on those focusing on single cells imaging, and finally on those imaging subcellular organelles and structures...
  9. ncbi Human papillomavirus viral load expressed as relative light units (RLU) correlates with the presence and grade of preneoplastic lesions of the uterine cervix in atypical squamous cells of undetermined significance (ASCUS) cytology
    M Origoni
    Department of Obstetrics and Gynecology, Vita Salute San Raffaele University School of Medicine at San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy
    Eur J Clin Microbiol Infect Dis 31:2401-6. 2012
    ..05). The HPV viral load in ASCUS cases significantly correlates with the severity of cervical cancer precursors. These data may have prognostic value, as they significantly correlate with the probability of a CIN2+ ...
  10. pmc Take advantage of time in your experiments: a guide to simple, informative kinetics assays
    Thomas D Pollard
    Department of Molecular Cellular and Developmental Biology, Yale University, New Haven, CT 06520 8103, USA
    Mol Biol Cell 24:1103-10. 2013
    ..These "transient-state" methods not only differ in concept from traditional approaches used to analyze enzyme reactions at steady state, but they are also applicable to learning about the dynamics of any biological process...
  11. pmc Rate of cervical cancer, severe intraepithelial neoplasia, and adenocarcinoma in situ in primary HPV DNA screening with cytology triage: randomised study within organised screening programme
    Ahti Anttila
    Mass Screening Registry of the Finnish Cancer Registry, Pieni Roobertinkatu 9, FIN 00130 Helsinki, Finland
    BMJ 340:c1804. 2010
    ..To assess the performance and impact of primary human papillomavirus (HPV) DNA screening with cytology triage compared with conventional cytology on cervical cancer and severe pre-cancerous lesions...
  12. pmc Circulating tumor cells in breast cancer: a tool whose time has come of age
    Ramona F Swaby
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    BMC Med 9:43. 2011
    ..We will also introduce their utility in pharmacodynamic monitoring for rational selection of molecularly targeted therapies and briefly address how they can help elucidate the biology of cancer metastasis...
  13. pmc Sensitivity, specificity, and clinical value of human papillomavirus (HPV) E6/E7 mRNA assay as a triage test for cervical cytology and HPV DNA test
    Maria Benevolo
    Agency for Public Health Lazio Sanità, Via di Santa Costanza 53, 00198 Rome, Italy
    J Clin Microbiol 49:2643-50. 2011
    ..It is also more efficient than cytology for the triage of HPV DNA-positive women. Nevertheless, its low sensitivity demands a strict follow-up of HPV DNA positive-mRNA negative cases...
  14. ncbi Abnormal cervicovaginal cytology with negative human papillomavirus testing
    Giovanni Negri
    Department of Pathology, Central Hospital Bolzano, Bolzano, Italy
    Cancer 111:280-4. 2007
    ..In this study, the authors investigated the occurrence and causes of abnormal cervicovaginal cytologies with negative HPV testing...
  15. pmc Cytology and human papillomavirus testing 6 to 12 months after ASCUS or LSIL cytology in organized screening to predict high-grade cervical neoplasia between screening rounds
    Ameli Tropé
    Department of Obstetrics and Gynaecology, Akershus University Hospital, Lørenskog, Norway
    J Clin Microbiol 50:1927-35. 2012
    ..In addition, the low CIN2+ risk among women with a negative Amplicor HPV test in our study confirms its safe use in a clinical setting...
  16. ncbi Human papillomavirus testing and liquid-based cytology: results at recruitment from the new technologies for cervical cancer randomized controlled trial
    Guglielmo Ronco
    Unit of Cancer Epidemiology, Centro per la Prevenzione Oncologica Piemonte, 10123 Turin, Italy
    J Natl Cancer Inst 98:765-74. 2006
    ....
  17. pmc Alternative technologies in cervical cancer screening: a randomised evaluation trial
    Ahti Anttila
    Mass Screening Registry, Finnish Cancer Registry, Liisankatu 21 B, FI 00170 Helsinki, Finland
    BMC Public Health 6:252. 2006
    ..A substantial amount of deaths from the disease could be prevented further by organised screening programmes or improving currently running programmes...
  18. pmc Using iterative cluster merging with improved gap statistics to perform online phenotype discovery in the context of high-throughput RNAi screens
    Zheng Yin
    Center for Bioinformatics, The Methodist Hospital Research Institute and Weill Cornell College of Medicine, 6565 Fannin Street, Houston, TX 77030, USA
    BMC Bioinformatics 9:264. 2008
    ..Arbitrarily extracted information causes biased analysis, while combining the complete existing datasets with each new image is intractable in high-throughput screens...
  19. ncbi [Flow cytometric analysis of HLA-DR, IL-6 and IL-8 expression by conjunctival epithelial cells from patients with prolonged topical antiglaucoma treatments]
    L Bensoussan
    Centre Hospitalier National d Ophtalmologie des Quinze Vingts, EA 3123 Université Pierre et Marie Curie Paris 6
    J Fr Ophtalmol 26:782-9. 2003
    ..To investigate the expression of three inflammation markers, HLA-DR, IL-6, and IL-8, by conjunctival epithelial cells obtained using impression cytology (IC) samples from long-term treated glaucoma patients...
  20. pmc Green light to illuminate signal transduction events
    Tamas Balla
    Section on Molecular Signal Transduction, Program on Developmental Neuroscience, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Trends Cell Biol 19:575-86. 2009
    ..Spatial definition of biochemical events followed with real-time temporal resolution has become a standard goal, and several new techniques are now breaking the resolution barrier of light microscopy...
  21. pmc Lifetime effects, costs, and cost effectiveness of testing for human papillomavirus to manage low grade cytological abnormalities: results of the NHS pilot studies
    Rosa Legood
    Health Economics Research Centre, Department of Public Health, University of Oxford, Oxford OX3 7LF
    BMJ 332:79-85. 2006
    ..To predict the incremental lifetime effects, costs, and cost effectiveness of using human papillomavirus testing to triage women with borderline or mildly dyskaryotic cervical smear results for immediate colposcopy...
  22. ncbi Human feeder layers for human embryonic stem cells
    M Amit
    Department of Obstetrics and Gynecology, Rambam Medical Center, Rambam Medical Center, Haifa, Isreal
    Biol Reprod 68:2150-6. 2003
    ....
  23. ncbi Fluorescence microscopy--avoiding the pitfalls
    Claire M Brown
    Life Sciences Complex Imaging Facility, Department of Biochemistry, McGill University, Montreal, Canada, H3G 1Y6
    J Cell Sci 120:1703-5. 2007
  24. pmc HPV testing as a triage for borderline or mild dyskaryosis on cervical cytology: results from the Sentinel Sites study
    R S Kelly
    Cancer Screening Evaluation Unit, Institute of Cancer Research, Richard Doll Building, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK
    Br J Cancer 105:983-8. 2011
    ..The aim of the present study was to study the impact of wider rollout of HPV triage for women with low-grade cytology on colposcopy referral and outcomes...
  25. ncbi Long-term follow-up of cervical abnormalities among women screened by HPV testing and cytology-Results from the Hammersmith study
    Jack Cuzick
    Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London, United Kingdom
    Int J Cancer 122:2294-300. 2008
    ..52, p = 0.001), whereas there was little difference according to initial cytology (HR = 1.64, p = 0.51)...
  26. pmc Triage of women with low-grade cervical lesions--HPV mRNA testing versus repeat cytology
    Sveinung Wergeland Sørbye
    Department of Clinical Pathology, The University Hospital of North Norway, Tromsø, Norway
    PLoS ONE 6:e24083. 2011
    ..A high specificity and positive predictive value (PPV) of the triage test is important to avoid unnecessary diagnostic and therapeutic procedures...
  27. pmc Accuracy of liquid based versus conventional cytology: overall results of new technologies for cervical cancer screening: randomised controlled trial
    Guglielmo Ronco
    Unit of Cancer Epidemiology, Centre for Cancer Prevention, Via S Francesco da Paola 31 10123 Turin, Italy
    BMJ 335:28. 2007
    ..To compare the accuracy of conventional cytology with liquid based cytology for primary screening of cervical cancer...
  28. ncbi What's next? Perspectives and future needs of cervical screening in Europe in the era of molecular testing and vaccination
    Elsebeth Lynge
    Institute of Public Health, University of Copenhagen, Østre Farimagsgade 5, DK 1014 København K, Denmark
    Eur J Cancer 45:2714-21. 2009
    ..To outline the perspectives for future control of cervical cancer in Europe...
  29. ncbi HPV triage for low grade (L-SIL) cytology is appropriate for women over 35 in mass cervical cancer screening using liquid based cytology
    Guglielmo Ronco
    Unit of Cancer Epidemiology, Centro per la Prevenzione Oncologica CPO, Via S Francesco da Paola 31, 10123 Turin, Italy
    Eur J Cancer 43:476-80. 2007
    ..5% (95%CI 58.3-70.3) at age 35-60. In conclusion, triaging by HPV testing performed better in women aged over 35 years than those younger. For older women, HPV triaging should also be considered for managing those with LSIL cytology...
  30. ncbi Screening with a primary human papillomavirus test does not increase detection of cervical cancer and intraepithelial neoplasia 3
    Laura Kotaniemi-Talonen
    Mass Screening Registry, Finnish Cancer Registry, Liisankatu 21 B, FI 00170 Helsinki, Finland
    Eur J Cancer 44:565-71. 2008
    ..To determine cross-sectional validity of primary human papillomavirus (HPV) screening in comparison to cytological screening...
  31. ncbi Interleukin-8 concentrations in conjunctival epithelium brush cytology samples correlate with neutrophil, eosinophil infiltration, and corneal damage
    T Miyoshi
    Department of Ophthalmology, Tachikawa Hospital, KKR, Tokyo, Japan
    Cornea 20:743-7. 2001
    ..CONCLUSION: IL-8 in the extracellular space of the conjunctival epithelium may play a role in the recruitment of neutrophils and possibly eosinophils and in the pathogenesis of corneal damage in severe allergic diseases...
  32. pmc Routine cervical screening with primary HPV testing and cytology triage protocol in a randomised setting
    L Kotaniemi-Talonen
    Mass Screening Registry, Finnish Cancer Registry, Liisankatu 21 B, FI 00170 Helsinki, Finland
    Br J Cancer 93:862-7. 2005
    ..With cytology triage, the specificity improves to the level of conventional cytology...
  33. ncbi Impression cytology: recent advances and applications in dry eye disease
    Eli Lopin
    Department of Ophthalmology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Ocul Surf 7:93-110. 2009
    ..Dry eye disease is one area in which IC has contributed to significant advances...
  34. ncbi Effect of study design and quality on unsatisfactory rates, cytology classifications, and accuracy in liquid-based versus conventional cervical cytology: a systematic review
    Elizabeth Davey
    Screening and Test Evaluation Program, School of Public Health, University of Sydney, Australia
    Lancet 367:122-32. 2006
    ..We reviewed the published work to assess the performance of liquid-based cytology relative to conventional cytology in primary studies assessed to be of low, medium, or high methodological quality...
  35. doi In vivo marking of single cells in chick embryos using photoactivation of GFP
    D A Stark
    Stowers Institute for Medical Research, Kansas City, Missouri, USA
    Curr Protoc Cell Biol . 2005
    ..The technique has the potential to be a less-invasive, accurate tool for in vivo studies that involve following cell lineage and cell migration...
  36. pmc Automated migration analysis based on cell texture: method & reliability
    Jianfeng Qin
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    BMC Cell Biol 6:9. 2005
    ..It was designed specifically to identify the impact of Second Hand Smoke (SHS) on endothelial cell migration but has broader applications. The analysis has two stages: (1) preprocessing of image texture, and (2) migration analysis...
  37. pmc Analysis of inadequate cervical smears using Shewhart control charts
    Wayne N Harrison
    Walsall Teaching Primary Care Trust, Lichfield House, WS1 1TE, UK
    BMC Public Health 4:25. 2004
    ..Furthermore, the proportion of inadequate smears is known to vary widely amongst providers. This study investigates this variation using Shewhart's theory of variation and control charts, and suggests strategies for addressing this...
  38. pmc Automated measurement of cell motility and proliferation
    Alfred Bahnson
    Automated Cell, Inc 390 William Pitt Way, Pittsburgh, PA 15238, USA
    BMC Cell Biol 6:19. 2005
    ..Here we describe a fully automated system in which images are acquired 24/7 from 384 well plates and are automatically processed to yield high-content motility and morphological data...
  39. ncbi Improving fluorescence-based assays for the in vitro analysis of cell adhesion and migration
    Paola Spessotto
    Division for Experimental Oncology 2, The National Cancer Institute CRO IRCCS, Aviano, PN, Italy
    Mol Biotechnol 20:285-304. 2002
    ....
  40. ncbi Analysis methods of human cell migration
    Frank Entschladen
    Institute of Immunology, Witten Herdecke University, Stockumer Street 10, 58448 Witten, Germany
    Exp Cell Res 307:418-26. 2005
    ..This review therefore gives an overview of the migration assays which are currently in use, describes the methods, and critically enlightens the particular advantages and disadvantages of each method...
  41. pmc Assessment of 1183 screen-detected, category 3B, circumscribed masses by cytology and core biopsy with long-term follow up data
    G Farshid
    BreastScreen SA, 1 Goodwood Road, Wayville 5065, South Australia
    Br J Cancer 98:1182-90. 2008
    ....
  42. ncbi Improvement of diagnostic accuracy and screening conditions with liquid-based cytology
    Doris Schledermann
    Department of Pathology, Odense University Hospital, Winsloewparken 15, 5000 Odense C, Denmark
    Diagn Cytopathol 34:780-5. 2006
    ..In addition, we focus on the optimized cellular material that shows the diagnostic details very clearly to the microscopist and leads to radically improved screening conditions...
  43. ncbi Criteria for organized cervical screening programs. Special emphasis on The Netherlands program
    Antonius G J M Hanselaar
    Department of Pathology, University Medical Center Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Acta Cytol 46:619-29. 2002
    ..Evaluation of medical and organizational aspects is mandatory. Cooperation between all involved parties is a prerequisite of creating a successful screening program...
  44. ncbi Morphogenesis of primary human biliary epithelial cells: induction in high-density culture or by coculture with autologous human hepatocytes
    M K Auth
    Liver Research Laboratories, Queen Elizabeth Medical Centre, and School of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK
    Hepatology 33:519-29. 2001
    ..These findings indicate that for human biliary ductular morphogenesis, epithelial cell-cell interactions are required but that mesenchymally derived factors such as HGF may not be important...
  45. ncbi Evaluation of p16INK4a expression in ThinPrep cervical specimens with the CINtec p16INK4a assay: correlation with biopsy follow-up results
    Jane L Meyer
    Cytyc Corporation, Marlborough, Massachusetts, USA
    Cancer 111:83-92. 2007
    ..The ability of this assay to accurately identify underlying high-grade lesions was assessed by using follow-up biopsies and comparing these results with Hybrid Capture 2 (Digene, Gaithersburg, Md) high-risk HPV (hc(2)) results...
  46. ncbi Pap test in a high-risk population comparison of conventional and liquid-base cytology
    Maria Lucia Utagawa
    Division of Pathology of Adolfo Lutz Institute, 01246 902 São Paulo, Brazil
    Diagn Cytopathol 31:169-72. 2004
    ....
  47. ncbi Reliability of sparing Papanicolaou test conventional reading in cases reported as No Further Review at AutoPap-assisted cytological screening: survey of 30,658 cases with follow-up cytological screening
    Grazia Maria Troni
    Istituto Scientifico Prevenzione Oncologica CSPO, Florence, Italy
    Cancer 111:93-8. 2007
    ..AutoPap-assisted smear reading has been proposed prior to conventional manual reading; the latter may be unnecessary for cases reported as No Further Review (NFR) and would be required for cases reported as Review (REV)...
  48. ncbi Clinical significance of immunocytochemistry for PIK3CA as a carcinogenesis-related marker on liquid-based cytology in cervical intraepithelial neoplasia
    Tomoko Goto
    Department of Obstetrics and Gynecology, Saitama Medical College, 38 Morohongo, Iruma gun, Saitama 350 0495, Japan
    Oncol Rep 15:387-91. 2006
    ..Thus, expression of PIK3CA was observed in liquid-based cytology in CIN lesions, which suggested its diagnostic significance in addition to the use of routine cervical cancer smear and the HPV screening program...
  49. pmc Accuracy of reading liquid based cytology slides using the ThinPrep Imager compared with conventional cytology: prospective study
    Elizabeth Davey
    Screening and Test Evaluation Program, School of Public Health, University of Sydney, NSW 2006, Australia
    BMJ 335:31. 2007
    ..To compare the accuracy of liquid based cytology using the computerised ThinPrep Imager with that of manually read conventional cytology...
  50. ncbi Testing automated liquid-based cytology samples with a manual liquid-based cytology method using residual cell suspensions from 500 ThinPrep cases
    John A Maksem
    Bostwick Laboratories, 2500 Sand Lake Road, Orlando, Florida 32809, USA
    Diagn Cytopathol 34:391-6. 2006
    ..Also, SILs often present as aggregates of cohesive cells which, if overlooked or ineffectively transferred to ALBC slides, would not be diagnosed...
  51. ncbi Interlaboratory reproducibility of liquid-based equivocal cervical cytology within a randomized controlled trial framework
    M Confortini
    Unit of Analytical and Biomolecular Cytology, Centro per lo Studio e la Prevenzione Oncologica, Florence, Italy
    Diagn Cytopathol 35:541-4. 2007
    ..The lack of reproducibility for ASCUS was not a result of the introduction of this new technology but rather to the low reproducibility of the ASCUS category itself stemming from intrinsic uncertainties in the reporting criteria...
  52. ncbi Immunohistochemical detection of p16INK4a in liquid-based cytology specimens on cell block sections
    Haiyan Liu
    Department of Pathology, Lehigh Valley Hospital, Allentown, Pennsylvania, USA
    Cancer 111:74-82. 2007
    ..To further improve the diagnostic accuracy of the ASC-H Papanicolaou smear and to reduce unnecessary procedures, the authors evaluated the utility of immunodetection of p16 in liquid-based cytology specimens on cell blocks...
  53. ncbi Histopathological outcomes of women with squamous cell carcinoma on cervical cytology
    Kittipat Charoenkwan
    Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
    Asian Pac J Cancer Prev 7:403-6. 2006
    ..The loop electrosurgical excision procedure (LEEP) remains an important measure for combined treatment and diagnosis...
  54. ncbi How accurate is cytological diagnosis of cervical glandular lesions?
    Marise A R Moreira
    Department of Pathology, School of Medicine, Federal University of Goias, Goias, Brazil
    Diagn Cytopathol 36:270-4. 2008
    ..The use of HPV DNA test alone or combined to screening glandular lesions may contribute to minimize the limitations of both conventional and LBC preparations to diagnose glandular abnormalities...
  55. ncbi Rapid, high throughput determination of cervical cytology specimen adequacy using a capillary-based cytometer
    Ryan Polina
    Invirion Diagnostics LLC, Oak Brook, Illinois 60523, USA
    Cytometry B Clin Cytom 74:133-6. 2008
    ..Use of this instrument reduced the amount of sample required by >90% and reduced the average per sample assay time from 120 s to 10 s compared with flow cytometry...
  56. ncbi Grading follicular lymphoma on fine needle aspiration specimens. Comparison with proliferative index by DNA image analysis and Ki-67 labeling index
    Wei Sun
    Division of Pathology and Laboratory Medicine, Department of Pathology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 053, Houston, Texas 77030, USA
    Acta Cytol 48:119-26. 2004
    ..To determine whether follicular lymphoma (FL) can be graded on fine needle aspiration (FNA) biopsies by determining the percentage of centroblasts in the neoplastic follicles on the smears...
  57. ncbi [The role of the cytological screening, HPV-test and the colposcopy for early detection of the precancerous lesions of the uterine cervix]
    S Ivanov
    Akush Ginekol (Sofiia) 46:45-9. 2007
    ..We tried to summarise our and foreign experience in the field of early finding and screening of the precancerous lesions of the uterine cervix...
  58. ncbi [Two cytological methods for screening for cervical cancer]
    Benny Kirschner
    Hvidovre Hospital, Patologiafdelingen
    Ugeskr Laeger 170:1933-7. 2008
    ..In spite of this, almost 150 Danish women die from the disease each year. There are currently two different methods for preparation of cervical samples: conventional Papanicolaou smear and liquid-based cytology...
  59. ncbi New strategies for cervical cancer screening in adolescents
    Susan Hayden Gray
    Division of Adolescent Young Adult Medicine, Department of Medicine, Children s Hospital Boston, MA 02115, USA
    Curr Opin Pediatr 16:344-9. 2004
    ....
  60. ncbi Liquid-based cytology: is this the way forward for cervical screening?
    Robin P Moseley
    The Pauline Cooper Department of Cytology, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    Cytopathology 13:71-82. 2002
    ..Our analysis of existing data does not support the nationwide implementation of LBC at present. Further studies are recommended in order to evaluate the place of this technology within the NHSCSP...
  61. ncbi Is it reality or an illusion that liquid-based cytology is better than conventional cervical smears?
    Robin Moseley
    Cytopathology 13:135-6. 2002
  62. ncbi Is it reality or an illusion that liquid-based cytology is better than conventional cervical smears? Authors' reply
    Amanda Herbert
    Cytopathology 13:133. 2002
  63. ncbi Towards a single cell cancer diagnosis. Multimodal and monocellular measurements of markers and morphology (5M)
    A Bocking
    Institute of Cytopathology, Heinrich Heine University Dusseldorf, Moorenstr 5, 40225 Dusseldorf, Germany
    Cell Oncol 26:73-9. 2004
  64. ncbi Comparison of two preparation methods for endocervical evaluation
    Hye Sun Kim
    Department of Pathology, Cheil General Hospital and Women s Healthcare Center, Kwandong University College of Medicine, Seoul, Republic of Korea
    Acta Cytol 51:742-8. 2007
    ....
  65. ncbi "Sip volume" as a quality indicator in liquid-based cervical cytology
    Mark E Sherman
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892 7374, USA
    Cancer 108:462-7. 2006
    ..It was hypothesized that the volumes required to prepare ThinPreps ("sip volumes") represent indicators of specimen quality...
  66. ncbi Preneoplastic and neoplastic cervical lesions as detected in Cytoblock sections: the importance of sampling women with bleeding symptoms
    M E Boon
    Leiden Cytology and Pathology Laboratoty, Leiden, The Netherlands
    Eur J Gynaecol Oncol 28:282-6. 2007
    ..The purpose was to use cervical samples to prepare Cytoblocks and use the subsequent paraffin sections for additional immunostaining in our studies on angiogenesis...
  67. pmc Effect of testing for human papillomavirus as a triage during screening for cervical cancer: observational before and after study
    Sue Moss
    Cancer Screening Evaluation Unit, Institute of Cancer Research, Sutton, Surrey SM2 5NG
    BMJ 332:83-5. 2006
    ..To assess the effect of introducing testing for human papillomavirus combined with liquid based cytology in women with low grade cytological abnormalities...
  68. ncbi Is it rational to start population-based cervical cancer screening at or soon after age 20? Analysis of time trends in preinvasive and invasive diseases
    Kristjan Sigurdsson
    Cancer Detection Clinic, Icelandic Cancer Society, 105 Reykjavik, Iceland
    Eur J Cancer 43:769-74. 2007
    ..The study confirms an increasing rate of preinvasive and invasive disease among younger women and indicates the benefit of starting organised screening at 2-3 year intervals soon after age 20...
  69. ncbi Liquid-based cytology versus conventional Papanicolaou smear in an organized screening program : a prospective randomized study
    Bjorn Strander
    Department of Obstetrics and Gynecology, Sahlgrenska Academy, University of Goteborg and Sahlgrenska University Hospital, Goteborg, Sweden
    Cancer 111:285-91. 2007
    ..The primary endpoint was histopathologic high-grade lesions in current and subsequent screening rounds. The secondary endpoints were cytologic diagnosis and inadequate samples...
  70. ncbi Screening for cervical cancer and initial treatment of patients with abnormal results from papanicolaou testing
    John B Bundrick
    Division of General Internal Medicine, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Mayo Clin Proc 80:1063-8. 2005
    ..Testing for HPV as an adjunct to cervical cytology for primary screening is now considered reasonable for many women older than 30 years...
  71. ncbi Fine-needle aspiration cytology in the diagnosis of cutaneous leishmaniasis
    Masoom Kassi
    Bolan Medical College Complex Hospital, Quetta, Pakistan
    Ann Saudi Med 24:93-7. 2004
    ..We compared fine-needle aspiration cytology (FNAC) with the conventional method of excisional biopsy to assess the efficacy, utility and accuracy of FNAC for the diagnosis of CL...
  72. ncbi Validation of a five-tier cytodiagnostic system for thyroid fine needle aspiration biopsies using cytohistologic correlation
    Brian J Yoder
    Department of Pathology, University of Florida, Gainesville, Florida 32610 0275, USA
    Thyroid 16:781-6. 2006
    ..We present our experience using a five-tier system, including the diagnostic terminology: benign, indeterminate, suspicious, malignant, and unsatisfactory...
  73. ncbi Proteomic analysis of high-grade dysplastic cervical cells obtained from ThinPrep slides using laser capture microdissection and mass spectrometry
    Ye Gu
    Northeastern University, Boston, Massachusetts 02115, USA
    J Proteome Res 6:4256-68. 2007
    ..With the study of additional clinical specimens, the differential abundance of proteins in high-grade dysplastic cells versus morphologically normal cervical cells may lead to validated novel biomarkers for cervical disease...
  74. ncbi A follow-up study of atypical squamous cells in gynecologic cytology using conventional papanicolaou smears and liquid-based preparations: the impact of the Bethesda System 2001
    Chris Yick Kwong Lee
    Department of Pathology, Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
    Am J Clin Pathol 127:548-55. 2007
    ..Introduction of dichotomous subcategorization of ASC is relevant, with ASC-H associated with a much higher risk of subsequent high-grade squamous lesions...
  75. ncbi Follow-up study of atypical glandular cells in gynecologic cytology using conventional Pap smears and liquid-based preparations: impact of the Bethesda System 2001
    Chris Yick Kwong Lee
    Department of Pathology, The University of Hong Kong and Hong Kong Sanatorium and Hospital, Hong Kong Special Administrative Region, China
    Acta Cytol 52:159-68. 2008
    ..This study evaluated the impact of the Bethesda System (TBS) 2001 in reporting of atypical glandular cells (AGC) when using conventional Pap smears (CS) and liquid-based cytology preparations (LBC)...
  76. ncbi Conventional Pap smear and liquid-based cytology as screening tools in low-resource settings in Latin America: experience of the Latin American screening study
    Adhemar Longatto-Filho
    Instituto Adolfo Lutz and Hospital Leonor M de Barros, Sao Paulo, Brazil
    Acta Cytol 49:500-6. 2005
    ....
  77. ncbi Evaluation of cervical screening strategies with adjunct high-risk human papillomavirus testing for women with borderline or mild dyskaryosis
    Johannes Berkhof
    Department of Clinical Epidemiology and Biostatistics, VU University Medical Centre, Amsterdam, The Netherlands
    Int J Cancer 118:1759-68. 2006
    ....
  78. ncbi Human papillomavirus DNA detection in the management of women with twice mildly abnormal cytological smears
    Linda Ho
    Department of Molecular Pathology, University College London, London, United Kingdom
    J Med Virol 69:118-21. 2003
    ..The utility of high-risk HPV detection in the management of women presenting with mild cytological abnormalities is discussed...
  79. ncbi Analysis of standard methods for diagnosing vaginitis: HIV infection does not complicate the diagnosis of vaginitis
    Beverly E Sha
    Department of Medicine, Section of Infectious Diseases, Rush University Medical Center, Chicago, IL, USA
    J Low Genit Tract Dis 11:240-50. 2007
    ..We sought to determine whether the standard diagnostic methods for vaginitis behave similarly among HIV-infected and at-risk seronegative women...
  80. ncbi A peer comparison program for the quality assurance of human papillomavirus DNA detection using the Digene Hybrid Capture II/SurePath method shows excellent analytic interlaboratory correlation
    Diane L Kuebler
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts
    Cancer 111:339-43. 2007
    ..In this report, the authors provide the results from a self-developed program between 2 cytology laboratories...
  81. ncbi Resolution of equivocal results with the Hybrid Capture II high-risk HPV DNA test: a cytologic/histologic review of 191 cases
    Stewart M Knoepp
    Department of Pathology, Massachusetts General Hospital and Harvard University, Boston, MA 02114, USA
    Diagn Mol Pathol 16:125-9. 2007
    ..These "equivocal" values are resulted as positive for hrHPV if either of 2 subsequent test values equals or exceeds 1.0 RLU/CO. Samples that show <1.0 RLU/CO after 2 repeat tests are resulted as negative for hrHPV...
  82. ncbi Human papilloma virus detection in liquid cytology, in situ hybridization and polymerase chain reaction
    F Alameda
    Virchows Arch 446:202-3. 2005
  83. ncbi Gynecological cytology: too old to be a pop star but too young to die
    Adhemar Longatto-Filho
    Diagn Cytopathol 35:672-3. 2007
  84. ncbi Comparison of the performance of rapid prescreening, 10% random review, and clinical risk criteria as methods of internal quality control in cervical cytopathology
    Suelene B N Tavares
    School of Pharmacy, Federal University of Goias, Goiania, Goias, Brazil
    Cancer 114:165-70. 2008
    ..Little direct comparison data are available comparing RPS with other more widely used IQC methods...
  85. pmc Commentary: Liquid automation refreshes Dr Papanicolaou
    Geoff Watts
    BMJ 335:35-6. 2007
  86. ncbi Measuring the significance of workload on performance of cytotechnologists in gynecologic cytology: a study using rapid prescreening
    Majorie Deschenes
    Department of Pathology, McGill University Health Center and McGill University, Montreal, Quebec, Canada
    Cancer 114:149-54. 2008
    ..Workload is extensively regulated and often used as a measure of quality in gynecologic cytology. Whether workload correlates with the sensitivity of screening in gynecologic cytology is not known...
  87. ncbi Liquid-based cervical cytology tests
    Sandra M Sulik
    J Fam Pract 51:378. 2002
  88. ncbi Endometrial brush cytology in the surveillance of post-menopausal patients under tamoxifen: a prospective longitudinal study
    Carole Mathelin
    Service de Gynecologie Obstetrique, Centre Hospitalier Universitaire, 1 Place de l Hopital, 67091 Strasbourg Cedex, France
    Eur J Obstet Gynecol Reprod Biol 132:126-8. 2007
    ..To evaluate cytological sampling of endometrium using Endobrush (Lab CCD, Paris, France) in the surveillance of tamoxifen-treated patients...
  89. ncbi [Impression cytology in patients with dry eye syndrome and various rheumatic diseases]
    Monika Oziebło-Kupczyk
    Klinika Okulistyki Ozieciecej Akademii Medycznej w Białymstoku
    Klin Oczna 108:420-3. 2006
    ..The aim of this study was to evaluate the cytological changes of bulbar conjunctiva in patients with various rheumatic diseases and dry eye syndrome...
  90. ncbi Evaluating the risk of cervical precancer with a combination of cytologic, virologic, and visual methods
    Sophia S Wang
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute NIH, 6120 Executive Boulevard, EPS MSC 7234, Bethesda, MD 20892 7234, USA
    Cancer Epidemiol Biomarkers Prev 14:2665-8. 2005
    ..We conclude that the clear discrimination of cervical cancer risk provided by multiple test modalities is consistent with our understanding of cervical etiology related to HPV natural history...
  91. ncbi Identification of Chlamydia trachomatis DNA in human papillomavirus (HPV) positive women with normal and abnormal cytology
    R R Finan
    Department of Obstetrics, St Georges Hospital, Beirut
    Arch Gynecol Obstet 266:168-71. 2002
    ..Collectively, this suggests that a causal relationship between HPV and CT infection in the development of CIN disease...
  92. pmc Ploidy manipulation of the gametophyte, endosperm and sporophyte in nature and for crop improvement: a tribute to Professor Stanley J. Peloquin (1921-2008)
    Rodomiro Ortiz
    International Maize and Wheat Improvement Center CIMMYT, Apdo Postal 6 641, 06600 Mexico, D F, Mexico
    Ann Bot 104:795-807. 2009
    ....
  93. ncbi Polymorphisms for the size of heterochromatic regions allow sex-independent quantification of post-BMT chimerism targeting metaphase and interphase cells
    I Buno
    Dpto de Biologia, Universidad Autonoma de Madrid, Spain
    Haematologica 84:138-41. 1999
    Fully quantitative cytological techniques for the analysis of hemopoietic chimerism are very limited and largely restricted to sex-chromosome detection after sex-mismatched bone marrow transplants (BMTs)...
  94. ncbi The dynamics of homologous chromosome pairing during male Drosophila meiosis
    Julio Vazquez
    Department of Biochemistry and Biophysics, University of California, San Francisco, 94143, USA
    Curr Biol 12:1473-83. 2002
    ..Due to limitations in available cytological techniques, the early stages of homologous chromosome pairing in male Drosophila have not been observed, and the ..
  95. pmc Niemann-Pick C variant detection by altered sphingolipid trafficking and correlation with mutations within a specific domain of NPC1
    X Sun
    Thoracic Diseases Research Unit, Department of Biochemistry and Molecular Biology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Am J Hum Genet 68:1361-72. 2001
    ..Our findings should be useful for the detection of NPC variants and also may provide significant new insight regarding NPC1 genotype/phenotype correlations...
  96. ncbi Persisting fetal microchimerism does not interfere with forensic Y-chromosome typing
    M Klintschar
    Institute of Legal Medicine, University Halle Wittenberg, Franzosenweg 1, Halle D 06112, Germany
    Forensic Sci Int 139:151-4. 2004
    ..The sensitivity of this approach exceeds that of cytological techniques combined with autosomal DNA typing...
  97. ncbi ASY1 coordinates early events in the plant meiotic recombination pathway
    E Sanchez-Moran
    School of Biosciences, University of Birmingham, Birmingham, UK
    Cytogenet Genome Res 120:302-12. 2008
    ..The development of molecular and cytological techniques in Arabidopsis, besides allowing investigation of the more conserved aspects of meiosis, are also ..
  98. ncbi Development of a PCR assay for detection of the oyster pathogen Bonamia ostreae and support for its inclusion in the Haplosporidia
    R B Carnegie
    School of Marine Sciences, University of Maine, Orono 04469, USA
    Dis Aquat Organ 42:199-206. 2000
    ..The PCR assay developed here is more sensitive and less ambiguous than standard histological and cytological techniques. Phylogenetic analysis of DNA sequence data confirmed B. ostreae to be a member of the Haplosporidia.
  99. ncbi Quantitative analysis of the Purkinje cell and the granule cell populations in the cerebellum of nude mice
    A Bakalian
    Laboratoire de Neurobiologie du Developpement, URA C N R S 1488, Universite Pierre et Marie Curie, Paris, France
    J Neurogenet 9:207-18. 1995
    ..1981). The present work was aimed at reappraising the claimed anomalies by using quantitative cytological techniques. We counted the Purkinje and the granule cells, on serial sagittal sections stained with thionin, in the ..
  100. ncbi Tandem use of immunofluorescent and DNA staining assays to validate nested PCR detection of mycoplasma
    Ashok Kumar
    Cell Biology, Institute of Pathology ICMR, P B No 4909, Safdarjang Hospital Campus, New Delhi, Delhi 110029, India
    In Vitro Cell Dev Biol Anim 44:189-92. 2008
    ..sensitivity to detect as low a contamination as a few organisms, was compared with the results from two cytological techniques employed in tandem...
  101. ncbi Development of one set of chromosome-specific microsatellite-containing BACs and their physical mapping in Gossypium hirsutum L
    Kai Wang
    National Key Laboratory of Crop Genetics and Germplasm Enhancement, Cotton Research Institute, Nanjing Agricultural University, Nanjing, 210095, Jiangsu Province, China
    Theor Appl Genet 115:675-82. 2007
    ....

Research Grants65

  1. STRUCTURE AND GENETIC CONTROL OF COLICINES
    Donald Helinski; Fiscal Year: 2005
    ..coli, Pseudomonas putida and Pseudomonas aeruginosa using biochemical, genetic and cytological techniques. RK2 encodes a replication initiation protein (TrfA) and a replication origin that has as its main ..
  2. Recombination pathway and partner choice during C. elegans meiosis
    DIANA ELIZABETH LIBUDA; Fiscal Year: 2013
    ..Also, utilizing a variety of genetic and cytological techniques, I will assess the roles of known meiotic proteins in promoting specific meiotic repair outcomes...
  3. The Role of IME4 and IME2 in Drosophila Gametogenesis
    CINTIA FABIANA HONGAY; Fiscal Year: 2010
    ..melanogaster's husbandry, genetics, molecular genetics and cytological techniques to investigate the role of IME4 and IME2 in meiosis, and the three year independent phase of this award in ..
  4. NEURONAL DEVELOPMENT INTERACTION AND ORGANIZATION
    Michael Bennett; Fiscal Year: 2000
    ..Cytology, Confocal Microscope and Antibody/Protein Cores provide cutting edge cytological techniques to provide the essential structural correlates to the physiological aspects of the Program...
  5. GENETIC ANALYSIS OF ENDOCYTOSIS
    Monty Krieger; Fiscal Year: 1990
    ..The combination of somatic cell genetics and molecular cytological techniques should help provide answers to fundamental questions about mammalian cell function in general, and LDL ..
  6. Endoscopic Therapy of Early Cancer in Barretts Esophagus
    Kenneth Wang; Fiscal Year: 2009
    ..cancer progression including aneuploidy, loss of heterozygosity for p53 or p16 performed using novel cytological techniques can be correlated with flow cytometry performed on tissue...
  7. ROLE OF PROTO-ONCOGENES IN THE DEVELOPMENT OF C. ELEGANS
    Mario Capecchi; Fiscal Year: 1990
    ..A combination of molecular and cytological techniques will be used to pinpoint the time and site of expression of each of these genes during development...
  8. ToxR and TcpP function and localization in V. cholerae
    JYL MATSON; Fiscal Year: 2007
    ..localization of these transcriptional activators and the promoter DMA they specifically bind using cytological techniques. We will also identify the mechanism controlling TcpP turnover in the absence of TcpH through the ..
  9. CHEMISTRY & MORPHOLOGY OF VITREOUS REGENERATION
    ERWIN HULTSCH; Fiscal Year: 1980
    ..in vitro experiments to analyze the metabolism of the vitreous cells, using chemical, pulse labelling, and cytological techniques. the effects of the extracellular vitreous matrix and its components on the biosynthetic and proliferative ..
  10. REGULATION OF CELLULAR PROLIFERATION
    Michael Prystowsky; Fiscal Year: 1991
    ..Molecular cytological techniques will be used to carry out these studies...
  11. Inverted Laser-Scanning Confocal Microscope
    Douglas Taatjes; Fiscal Year: 2004
    ..It will also afford the capacity for advanced high-quality imaging capabilities and ensure sustained and efficient use for the UVM biomedical research community for the future. ..
  12. MOLECULAR DETERMINANTS OF ANGIOGENSIS IN ORAL CANCER
    Mark Lingen; Fiscal Year: 2005
    ....
  13. Oral Cancer, Chemoprevention, and Anti-Angiogenesis
    Mark Lingen; Fiscal Year: 2009
    ..abstract_text> ..
  14. Molecular Profiling of Premalignant Oral Lesions
    Mark Lingen; Fiscal Year: 2008
    ..This molecular analysis may also greatly improve diagnostic prediction compared to the cellular pattern recognition currently used by pathologists. [unreadable] [unreadable]..
  15. Automated Tissue Arrayer
    Mark Lingen; Fiscal Year: 2004
    ..An already established Internal Advisory Committee will oversee an equitable and appropriate use by a broad disciplinary group of scientists while giving priority to NIH-supported groups. ..
  16. Actin-based Neuronal State Changes
    Martha U Gillette; Fiscal Year: 2010
    ..Sleep disorders, learning/memory impairments, drug-addiction and aging will be direct beneficiaries. ..
  17. A Novel Technique of Imposing Femtonewton Forces
    Jin Yu Shao; Fiscal Year: 2007
    ..Therefore, the EMAT should have great potential to make an impact in the field of single molecule and single bond biophysics. [unreadable] [unreadable]..
  18. Micro-Thickness Collagen Membranes in Tissue Engineering
    Robert Vernon; Fiscal Year: 2007
    ..Moreover, data from this work will serve as a foundation for further development of TEBVs. Accordingly, this application is well suited to the purpose of the R21 mechanism. [unreadable] [unreadable] [unreadable]..
  19. PHYSIOLOGICAL CHEMISTRY OF INTEGRIN FUNCTION
    Michael Dustin; Fiscal Year: 2007
    ..These experiments should provide new insight into regulation of integrin function and identify potential therapeutic targets for regulation of leukocyte integrins. ..
  20. Alloantigen exposure influences infection threshold
    MARY BURKHARD; Fiscal Year: 2006
    ..Because these therapies would work in a virus non-specific manner, they would have potential use at the population level against multiple virus subtypes. ..
  21. Imageable tumor-targeting bacteria
    Ming Zhao; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  22. Nanoparticle Targeting to Control Angiogenesis
    JEFFREY DAVIDSON; Fiscal Year: 2006
    ..The objective is to design drug delivery systems that will specifically target pathological angiogenesis with minimal effects on the normal vasculature. ..
  23. Probing single proteins in nanofabricated bioenvironment
    Daniel Chiu; Fiscal Year: 2006
    ..Gaining a better understanding of the true in vivo activities of proteins inside cells is critical for developing new drugs that target these proteins for the treatment of devastating diseases. ..
  24. Myocytes sense substrate stiffness - New materials
    Dennis Discher; Fiscal Year: 2006
    ..PEM coating of stents will also be examined for inhibiting the proliferative response of smooth muscle cells implicated in restenosis. ..
  25. Microscale control of stem cell signaling using cell patterning and perfusion
    Joel Voldman; Fiscal Year: 2010
    ..Our technology provides a new window into stem cell biology that will help determine new ways to control their behavior. ..
  26. Targeted tumoricidal bacteria
    Ming Zhao; Fiscal Year: 2007
    ..Future human trials of the tumor-killing bacteria can be held after the Phase I and Phase II grant periods are completed. [unreadable] [unreadable] [unreadable]..
  27. Dual-color tumor-host imaging models
    Meng Yang; Fiscal Year: 2007
    ..These models have significant commercial potential for discovery and development of stroma-targeted and anti-angiogenesis drugs. [unreadable] [unreadable] [unreadable]..
  28. The CXCR4-SDF-1 Axis in Metastatic Rhabdomyosarcoma
    Mariusz Ratajczak; Fiscal Year: 2009
    ..This work will be of relevance for designing strategies to block the SDF-1-CXCR4 axis to treat CXCR4-positive cancers. ..
  29. 9th International Neurotoxicology Assoc (INA9) Meeting
    Michael Aschner; Fiscal Year: 2003
    ....
  30. Development of a Urological CD Cell Typing System
    Peter Nelson; Fiscal Year: 2009
    ..These studies will involve the evaluation of in vitro growth characteristics, cellular gene expression, organ topography, inter-species conservation, and transgenic animal models. ..
  31. Orthotopic models of tumor angiogenesis and blood flow
    Meng Yang; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  32. Therapeutic hair follicle-derived neurospheres
    Meng Yang; Fiscal Year: 2007
    ..Human hair- follicle bulge cells will be further characterized and developed for therapeutic potential for nerve regeneration in Phase III. [unreadable]..
  33. Cloning a major gene for mouse adenovirus susceptibility
    Katherine R Spindler; Fiscal Year: 2010
    ..The project is expected to identify a previously undescribed intractiorT^ieT^eerrK6sfiTrTrmrne res immune evasion, thus increasing our understanding of viral infections and mechanisms of host response to pathogens. ~ ..
  34. A Microfluidic Chemotaxis High Throughput System
    Ivar Meyvantsson; Fiscal Year: 2007
    ..To enable the discovery of drugs to block this process, we are developing plastic devices for high throughput cell migration assays in defined chemical gradients. [unreadable] [unreadable] [unreadable]..
  35. Analysis of Circulating Tumor Cells in a Phase I/II Study for Breast Cancer
    Ramona Swaby; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  36. Biomechanics on Neutrophil Rolling on the Endothelium
    Jin Yu Shao; Fiscal Year: 2006
    ..The microvillus mechanics will be studied with the optical tweezers, combined with the micropipette manipulation system. ..
  37. New Mouse Mutation Exhibiting Failed Fertilization
    Mary Ann Handel; Fiscal Year: 2006
    ..Thus, an expeditious and focused attack over a relatively short funding period is desirable to bring the project to the point of setting priorities for future research and development of the concept. ..
  38. THE DAZ GENES AND EARLY GERM CELL DEVELOPMENT
    Renee Reijo Pera; Fiscal Year: 2003
    ..abstract_text> ..
  39. Profiling individual synaptic vesicles with nanofluidics
    Daniel Chiu; Fiscal Year: 2003
    ....
  40. Large Scale Chemical Screen Against Pathogenic Bacteria
    Sanford Simon; Fiscal Year: 2003
    ..coli system that has been optimized for the colorimetric detection of channels that are open. These E. coli will then be screened with a chemical library to detect agents that open these channels. ..
  41. CELLULAR AND MOLECULAR BASIS OF HIV BASED THROMBOCYTOPEN
    Mariusz Ratajczak; Fiscal Year: 2002
    ..In toto, the studies proposed in this grant will increase the knowledge about pathogenesis of AIDS associated thrombocytopenia and may lead to development of new strategies for its treatment of prevention. (End of Abstract) ..
  42. RHOMOCYCSTEINASE FOR HOMOCYSTEINE ASSAY
    Yuying Tan; Fiscal Year: 2002
    ..The tHCY enzymatic kits for these applications will be ready for commercial launch at this point. PROPOSED COMMERCIAL APPLICATION: Not Available ..
  43. OPSIN BIOGENESIS AND RETINITIS PIGMENTOSA
    Sanford Simon; Fiscal Year: 2002
    ....
  44. MOLECULAR ALTERATIONS IN PROSTATE CANCER PROGRESSION
    Peter Nelson; Fiscal Year: 2002
    ..3) Compile and evaluate a panel of cancer-phenotype associated products for prognostic relevance. ..
  45. PEDIATRIC ONCOLOGY GROUP STUDIES
    Thomas McLean; Fiscal Year: 2002
    ....
  46. Inhibitors of 5alpha-reductase for acne therapy
    Lingna Li; Fiscal Year: 2002
    ..PROPOSED COMMERCIAL APPLICATIONS: Liposomal 4-MA will be developed as a topical selectively targeted therapeutic for acne for which they should be a very market. ..
  47. Photon Migration for Measurement of Small Tissue Volumes
    Vasan Venugopalan; Fiscal Year: 2001
    ..abstract_text> ..
  48. HIGH-PRECISION FLOW CYTOMETRY OF BACTERIA AND VIRUSES
    Howard Shapiro; Fiscal Year: 2004
    ..The relationship between staining intensity and nucleic acid type and content in viruses, will be investigated, with a view toward refining cytometric virus detection and identification. ..
  49. GENETICS OF PROSTATE CANCER SUSCEPTIBILITY
    Peter Nelson; Fiscal Year: 2005
    ..The resulting data will provide information about the type and distribution of mutations in high-risk families as well as provide useful information for understanding genetic heterogeneity of prostate cancer. ..
  50. A Program for Expanding ELSI Undergraduate Pedagogy
    Ronald Green; Fiscal Year: 2005
    ..This proposal represents a logical next step in the employment of the skills and resources we have developed at Dartmouth for undergraduate ELSI education. ..
  51. Enzyme therapy for hyperhomocysteinemia
    Yuying Tan; Fiscal Year: 2005
    ..Phase II results will lead to an IND for MEGC-PEG-rMETase for end stage renal disease patients and other patients with intractable hyperhomocysteinemia and high cardiovascular disease mortality. ..
  52. Multiplex system for stem cell culture and in situ assay
    Joel Voldman; Fiscal Year: 2004
    ..abstract_text> ..
  53. MEIOSIS IN MEN AND RISKS ASSOCIATED WITH ICSI
    Renee Reijo Pera; Fiscal Year: 2005
    ..They propose to extend their findings and use their new technology in the genetics of human reproduction by using single sperm PCR to examine the germ cells of infertile men for DAZ deletions and defects in DNA repair and recombination. ..
  54. Discovery of novel fluorescent reporter genes
    Ming Zhao; Fiscal Year: 2004
    ..Reporters with spectral properties that can be used for whole-body imaging of tumors in the lung and their metastases will be candidates for further development for numerous applications of multi-color imaging. ..
  55. CYTOMETRIC TUBERCULOSIS DETECTION AND SENSITIVITY TESTS
    Howard Shapiro; Fiscal Year: 2005
    ..bovis, M. smegmatis, and M. tuberculosis H37Ra, and evaluate the suitability of fluorescent nitrate reductase substrates for detection and quantification of mycobacterial strains expressing that enzyme. ..
  56. Imaging single proteins in vivo with quantum dots
    Sanford Simon; Fiscal Year: 2008
    ..Longer-term strategic directions will include trying to develop the technology for chemically tagging interacting proteins and technologies for tracking proteins for longer time periods as they move in three dimensions. ..
  57. CHOLINERGIC REGULATION OF THE CIRCADIAN CLOCK
    Martha Gillette; Fiscal Year: 2004
    ....
  58. Profiling Biochemical Contents of Single Mitochondria
    Daniel Chiu; Fiscal Year: 2009
    ..While our focus here is on the analysis of individual mitochondria, we believe our method can be applied equally well to the chemical analysis of other subcellular organelles and compartments. ..
  59. Human papillomavirus as a risk factor for HIV infection
    PETER CHIN HONG; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  60. PHYSIOLOGICAL SUBSTRATES OF A CIRCADIAN OSCILLATOR
    Martha Gillette; Fiscal Year: 2004
    ....
  61. Effect of Pertussis Toxin on Cough in Guinea Pig
    NICHOLAS CARBONETTI; Fiscal Year: 2005
    ..abstract_text> ..