tissue engineering

Summary

Summary: Generating tissue in vitro for clinical applications, such as replacing wounded tissues or impaired organs. A cell culture facility is required for cell harvest and expansion.

Top Publications

  1. ncbi Adipose-derived stem cells for regenerative medicine
    Jeffrey M Gimble
    Stem Cell Biology Laboratory and Clinical Nutrition Research Unit, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Circ Res 100:1249-60. 2007
  2. pmc Control of stem cell fate by physical interactions with the extracellular matrix
    Farshid Guilak
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Cell Stem Cell 5:17-26. 2009
  3. ncbi Adult mesenchymal stem cells for tissue engineering versus regenerative medicine
    Arnold I Caplan
    Skeletal Research Center, Department of Biology, Case Western Reserve University, Cleveland, Ohio, USA
    J Cell Physiol 213:341-7. 2007
  4. ncbi Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering
    M P Lutolf
    Integrative Biosciences Institute, Ecole Polytechnique Federale de Lausanne EPFL, Building AA B 039, CH 1015 Lausanne, Switzerland
    Nat Biotechnol 23:47-55. 2005
  5. ncbi Porosity of 3D biomaterial scaffolds and osteogenesis
    Vassilis Karageorgiou
    Department of Chemical and Biological Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA
    Biomaterials 26:5474-91. 2005
  6. ncbi Corneal reconstruction with tissue-engineered cell sheets composed of autologous oral mucosal epithelium
    Kohji Nishida
    Department of Ophthalmology, Osaka University Medical School, Suita, Osaka, Japan
    N Engl J Med 351:1187-96. 2004
  7. ncbi Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering
    K Rezwan
    Department of Materials, Imperial College London, Prince Consort Road, London SW7 2BP, UK
    Biomaterials 27:3413-31. 2006
  8. ncbi Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart
    Harald C Ott
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Nat Med 14:213-21. 2008
  9. ncbi Decellularization of tissues and organs
    Thomas W Gilbert
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, 100 Technology Drive, Suite 200, Pittsburgh, PA 15219, USA
    Biomaterials 27:3675-83. 2006
  10. ncbi Exploring and engineering the cell surface interface
    Molly M Stevens
    Department of Materials and Institute for Biomedical Engineering, Imperial College of Science, Technology, and Medicine, Prince Consort Road, London SW7 2BP, UK
    Science 310:1135-8. 2005

Detail Information

Publications334 found, 100 shown here

  1. ncbi Adipose-derived stem cells for regenerative medicine
    Jeffrey M Gimble
    Stem Cell Biology Laboratory and Clinical Nutrition Research Unit, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Circ Res 100:1249-60. 2007
    ..The isolation, characterization, and preclinical and clinical application of adipose-derived stem cells (ASCs) are reviewed in this article...
  2. pmc Control of stem cell fate by physical interactions with the extracellular matrix
    Farshid Guilak
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Cell Stem Cell 5:17-26. 2009
    ..Here, we review some of the physical processes by which cues from the ECM can influence stem cell fate, with particular relevance to the use of stem cells in tissue engineering and regenerative medicine.
  3. ncbi Adult mesenchymal stem cells for tissue engineering versus regenerative medicine
    Arnold I Caplan
    Skeletal Research Center, Department of Biology, Case Western Reserve University, Cleveland, Ohio, USA
    J Cell Physiol 213:341-7. 2007
    ..The MSCs have been used in preclinical models for tissue engineering of bone, cartilage, muscle, marrow stroma, tendon, fat, and other connective tissues...
  4. ncbi Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering
    M P Lutolf
    Integrative Biosciences Institute, Ecole Polytechnique Federale de Lausanne EPFL, Building AA B 039, CH 1015 Lausanne, Switzerland
    Nat Biotechnol 23:47-55. 2005
    ....
  5. ncbi Porosity of 3D biomaterial scaffolds and osteogenesis
    Vassilis Karageorgiou
    Department of Chemical and Biological Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA
    Biomaterials 26:5474-91. 2005
    ..New fabrication techniques, such as solid-free form fabrication, can potentially be used to generate scaffolds with morphological and mechanical properties more selectively designed to meet the specificity of bone-repair needs...
  6. ncbi Corneal reconstruction with tissue-engineered cell sheets composed of autologous oral mucosal epithelium
    Kohji Nishida
    Department of Ophthalmology, Osaka University Medical School, Suita, Osaka, Japan
    N Engl J Med 351:1187-96. 2004
    ..We studied the use of autologous oral mucosal epithelial cells as a source of cells for the reconstruction of the corneal surface...
  7. ncbi Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering
    K Rezwan
    Department of Materials, Imperial College London, Prince Consort Road, London SW7 2BP, UK
    Biomaterials 27:3413-31. 2006
    Biodegradable polymers and bioactive ceramics are being combined in a variety of composite materials for tissue engineering scaffolds...
  8. ncbi Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart
    Harald C Ott
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Nat Med 14:213-21. 2008
    ..By day 8, under physiological load and electrical stimulation, constructs could generate pump function (equivalent to about 2% of adult or 25% of 16-week fetal heart function) in a modified working heart preparation...
  9. ncbi Decellularization of tissues and organs
    Thomas W Gilbert
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, 100 Technology Drive, Suite 200, Pittsburgh, PA 15219, USA
    Biomaterials 27:3675-83. 2006
    Decellularized tissues and organs have been successfully used in a variety of tissue engineering/regenerative medicine applications, and the decellularization methods used vary as widely as the tissues and organs of interest...
  10. ncbi Exploring and engineering the cell surface interface
    Molly M Stevens
    Department of Materials and Institute for Biomedical Engineering, Imperial College of Science, Technology, and Medicine, Prince Consort Road, London SW7 2BP, UK
    Science 310:1135-8. 2005
    ..Far-reaching implications are emerging for applications including medical implants, cell supports, and materials that can be used as instructive three-dimensional environments for tissue regeneration...
  11. pmc Engineering cartilage tissue
    Cindy Chung
    Department of Bioengineering, University of Pennsylvania, 240 Skirkanich Hall, 210 S 33rd Street, Philadelphia, PA 19104, USA
    Adv Drug Deliv Rev 60:243-62. 2008
    Cartilage tissue engineering is emerging as a technique for the regeneration of cartilage tissue damaged due to disease or trauma...
  12. ncbi Tissue engineering and regenerative medicine -where do we stand?
    Raymund E Horch
    Department of Plastic and Hand Surgery and Laboratory for Tissue Engineering and Regenerative Medicine, Friedrich Alexander University Erlangen Nuernberg, Erlangen, Germany
    J Cell Mol Med 16:1157-65. 2012
    b>Tissue Engineering (TE) in the context of Regenerative Medicine (RM) has been hailed for many years as one of the most important topics in medicine in the twenty-first century...
  13. pmc Nanotechnology in drug delivery and tissue engineering: from discovery to applications
    Jinjun Shi
    MIT Harvard Center for Cancer Nanotechnology Excellence, Laboratory of Nanomedicine and Biomaterials, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nano Lett 10:3223-30. 2010
    ..Herein, we discuss two important aspects of nanomedicine, drug delivery and tissue engineering, highlighting the advances we have recently experienced, the challenges we are currently facing, and what we ..
  14. pmc Recent advances in bone tissue engineering scaffolds
    Susmita Bose
    W M Keck Biomedical Materials Research Lab, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164 2920, USA
    Trends Biotechnol 30:546-54. 2012
    ..In this review, we highlight recent advances in bone scaffolds and discuss aspects that still need to be improved...
  15. ncbi Clinical transplantation of a tissue-engineered airway
    Paolo Macchiarini
    Department of General Thoracic Surgery, Hospital Clinic, Barcelona, Spain
    Lancet 372:2023-30. 2008
    ..We aimed to bioengineer tubular tracheal matrices, using a tissue-engineering protocol, and to assess the application of this technology in a patient with end-stage airway disease...
  16. pmc Tissue-engineered lungs for in vivo implantation
    Thomas H Petersen
    Department of Biomedical Engineering, Yale University, New Haven, CT 06520, USA
    Science 329:538-41. 2010
    ..Although representing only an initial step toward the ultimate goal of generating fully functional lungs in vitro, these results suggest that repopulation of lung matrix is a viable strategy for lung regeneration...
  17. ncbi A three-dimensional nanofibrous scaffold for cartilage tissue engineering using human mesenchymal stem cells
    W J Wan Ju Li
    Department of Health and Human Services, Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis, and Musculoskeletal and Skin Diseases, National Institute of Health, Bethesda, MD 20892, USA
    Biomaterials 26:599-609. 2005
    The utilization of adult stem cells in tissue engineering is a promising solution to the problem of tissue or organ shortage...
  18. ncbi Electrospinning: applications in drug delivery and tissue engineering
    Travis J Sill
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA
    Biomaterials 29:1989-2006. 2008
    Despite its long history and some preliminary work in tissue engineering nearly 30 years ago, electrospinning has not gained widespread interest as a potential polymer processing technique for applications in tissue engineering and drug ..
  19. pmc An overview of tissue and whole organ decellularization processes
    Peter M Crapo
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Biomaterials 32:3233-43. 2011
    ..An overview of decellularization methods, their effect upon resulting ECM structure and composition, and recently described perfusion techniques for whole organ decellularization techniques are presented herein...
  20. ncbi Tissue-engineered autologous bladders for patients needing cystoplasty
    Anthony Atala
    Department of Urology and Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Lancet 367:1241-6. 2006
    ..The presence of such segments in the urinary tract has been associated with many complications. We explored an alternative approach using autologous engineered bladder tissues for reconstruction...
  21. ncbi Electrospinning of collagen nanofibers
    Jamil A Matthews
    Department of Physiology, Virginia Commonwealth University, Richmond, Virginia 23298 0551, USA
    Biomacromolecules 3:232-8. 2002
    ..The structural, material, and biological properties of electrospun collagen suggest that this material may represent a nearly ideal tissue engineering scaffold.
  22. pmc Nanotechnological strategies for engineering complex tissues
    Tal Dvir
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nat Nanotechnol 6:13-22. 2011
    b>Tissue engineering aims at developing functional substitutes for damaged tissues and organs...
  23. ncbi Hydrogels for tissue engineering: scaffold design variables and applications
    Jeanie L Drury
    Department of Biologic and Materials Science, University of Michigan, Room 5210, Ann Arbor, MI 48109, USA
    Biomaterials 24:4337-51. 2003
    Polymer scaffolds have many different functions in the field of tissue engineering. They are applied as space filling agents, as delivery vehicles for bioactive molecules, and as three-dimensional structures that organize cells and ..
  24. ncbi The design of scaffolds for use in tissue engineering. Part I. Traditional factors
    S Yang
    Design Research Center, School of Mechanical and Production Engineering, Nanyang Technological University, Singapore
    Tissue Eng 7:679-89. 2001
    In tissue engineering, a highly porous artificial extracellular matrix or scaffold is required to accommodate mammalian cells and guide their growth and tissue regeneration in three dimensions...
  25. ncbi Biocompatibility and osteogenesis of biomimetic nano-hydroxyapatite/polyamide composite scaffolds for bone tissue engineering
    Huanan Wang
    Research Center for Nano Biomaterials, Analytical and Testing Center, Sichuan University, Chengdu, 610064, PR China
    Biomaterials 28:3338-48. 2007
    ..All these results indicate that the scaffolds fulfill the basic requirements of bone tissue engineering scaffold, and have the potential to be applied in orthopedic, reconstructive and maxillofacial surgery.
  26. ncbi Self-assembly and mineralization of peptide-amphiphile nanofibers
    J D Hartgerink
    Department of Materials Science and Engineering, Medical School, Northwestern University, 2225 North Campus Drive, Evanston, IL 60208, USA
    Science 294:1684-8. 2001
    ..This alignment is the same as that observed between collagen fibrils and hydroxyapatite crystals in bone...
  27. ncbi Tissue engineered myoblast sheets improved cardiac function sufficiently to discontinue LVAS in a patient with DCM: report of a case
    Yoshiki Sawa
    Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka, 565 0871, Japan
    Surg Today 42:181-4. 2012
    ..These findings suggest that cellular therapy using myoblast sheets is a promising new strategy for treating patients with end-stage DCM. This method might be an effective alternative to heart transplantation in the near future...
  28. ncbi The impact of PLGA scaffold orientation on in vitro cartilage regeneration
    Yingying Zhang
    Department of Plastic and Reconstructive Surgery, Shanghai 9th People s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Tissue Engineering, Shanghai, PR China
    Biomaterials 33:2926-35. 2012
    ..These results indicated that the longitudinal microtubular orientation of scaffolds can efficiently improve the structure and function of in vitro engineered cartilage...
  29. ncbi Tracheobronchial transplantation with a stem-cell-seeded bioartificial nanocomposite: a proof-of-concept study
    Philipp Jungebluth
    Advanced Center for Translational REGenerative Medicine, Karolinska Institutet, Stockholm, Sweden
    Lancet 378:1997-2004. 2011
    ..We report the clinical transplantation of the tracheobronchial airway with a stem-cell-seeded bioartificial nanocomposite...
  30. pmc Marine polysaccharides: a source of bioactive molecules for cell therapy and tissue engineering
    Karim Senni
    Seadev FermenSys SAS, Technopole Brest Iroise, France
    Mar Drugs 9:1664-81. 2011
    ..Marine polysaccharides present a real potential for natural product drug discovery and for the delivery of new marine derived products for therapeutic applications...
  31. ncbi Designing materials for biology and medicine
    Robert Langer
    Department of Chemical Engineering, Massachusetts Institute of Technology, Building E25 342, Cambridge, Massachusetts 02139, USA
    Nature 428:487-92. 2004
    ..These include synthetic replacements for biological tissues, designing materials for specific medical applications, and materials for new applications such as diagnostics and array technologies...
  32. ncbi The role of bioreactors in tissue engineering
    Ivan Martin
    Departments of Surgery and of Research, University Hospital Basel, Hebelstrasse 20, ZLF, Room 405, 4031, Basel, Switzerland
    Trends Biotechnol 22:80-6. 2004
    ..In addition, by automating and standardizing tissue manufacture in controlled closed systems, bioreactors could reduce production costs, thus facilitating a wider use of engineered tissues...
  33. ncbi Bone tissue engineering: a review in bone biomimetics and drug delivery strategies
    Joshua R Porter
    Department of Mechanical Engineering, School of Biomedical Engineering, Colorado State University, Fort Collins, CO 80523, USA
    Biotechnol Prog 25:1539-60. 2009
    ..biocompatibility, and controllable biodegradability, polymers have emerged as the principal material in bone tissue engineering. This article briefly reviews the physiological and anatomical characteristics of native bone, describes key ..
  34. ncbi Review: mineralization of synthetic polymer scaffolds for bone tissue engineering
    James D Kretlow
    Department of Bioengineering, Rice University, Houston, Texas 77251, USA
    Tissue Eng 13:927-38. 2007
    ..Conversely, much work in the field of bone tissue engineering has used composite materials consisting of a mineralized phase or materials designed to mineralize rapidly ..
  35. pmc Hydrogels as extracellular matrix mimics for 3D cell culture
    Mark W Tibbitt
    Department of Chemical and Biological Engineering, University of Colorado, Boulder, CO, USA
    Biotechnol Bioeng 103:655-63. 2009
    ..Ultimately, advances in synthetic-biologic hydrogel hybrids are needed to provide robust platforms for investigating cell physiology and fabricating tissue outside of the organism...
  36. pmc Microporous nanofibrous fibrin-based scaffolds for bone tissue engineering
    Thanaphum Osathanon
    Department of Oral Biology, School of Dentistry, University of Washington, Seattle, WA 98195, United States
    Biomaterials 29:4091-9. 2008
    The fibrotic response of the body to synthetic polymers limits their success in tissue engineering and other applications...
  37. pmc Adult mesenchymal stem cells and cell-based tissue engineering
    Rocky S Tuan
    National Institute of Arthritis, and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Arthritis Res Ther 5:32-45. 2003
    ..bone marrow stroma and a number of connective tissues, has provided exciting prospects for cell-based tissue engineering and regeneration...
  38. ncbi Silk-based biomaterials
    Gregory H Altman
    Department of Chemical and Biological Engineering, Bioengineering Center, Tufts University, 4 Colby Street, Medford, MA 02155, USA
    Biomaterials 24:401-16. 2003
    ..For example, in designing scaffolds for tissue engineering these properties are particularly relevant and recent results with bone and ligament formation in vitro ..
  39. ncbi Mesenchymal stem cells: molecular targets for tissue engineering
    Neeraj Kumar Satija
    Stem Cell Gene Therapy Research Group, Institute of Nuclear Medicine and Allied Sciences, Timarpur, Delhi, India
    Stem Cells Dev 16:7-23. 2007
    ..Their extensive proliferation and transdifferentiation potential makes them best suited for tissue engineering applications...
  40. pmc Foreign body reaction to biomaterials
    James M Anderson
    Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, United States
    Semin Immunol 20:86-100. 2008
    ..with tissue-engineered constructs containing proteins, cells, and other biological components for use in tissue engineering and regenerative medicine...
  41. ncbi Extracellular matrix as a biological scaffold material: Structure and function
    Stephen F Badylak
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Acta Biomater 5:1-13. 2009
    ..from the extracellular matrix (ECM) of intact mammalian tissues have been successfully used in a variety of tissue engineering/regenerative medicine applications both in preclinical studies and in clinical applications...
  42. pmc Reproducible, ultra high-throughput formation of multicellular organization from single cell suspension-derived human embryonic stem cell aggregates
    Mark D Ungrin
    Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 3:e1565. 2008
    ....
  43. ncbi Making tissue engineering scaffolds work. Review: the application of solid freeform fabrication technology to the production of tissue engineering scaffolds
    E Sachlos
    Department of Materials, University of Oxford, Parks Road, Oxford, OX1 3PH, UK
    Eur Cell Mater 5:29-39; discussion 39-40. 2003
    b>Tissue engineering is a new and exciting technique which has the potential to create tissues and organs de novo. It involves the in vitro seeding and attachment of human cells onto a scaffold...
  44. ncbi Tissue engineering--current challenges and expanding opportunities
    Linda G Griffith
    Department of Chemical Engineering, Division of Bioengineering and Environmental Health, and Biotechnology Process Engineering Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 295:1009-14. 2002
    b>Tissue engineering can be used to restore, maintain, or enhance tissues and organs...
  45. pmc Fabrication, characterization and cellular compatibility of poly(hydroxy alkanoate) composite nanofibrous scaffolds for nerve tissue engineering
    Elahe Masaeli
    Department of Textile Engineering, Isfahan University of Technology, Isfahan, Iran
    PLoS ONE 8:e57157. 2013
    b>Tissue engineering techniques using a combination of polymeric scaffolds and cells represent a promising approach for nerve regeneration...
  46. ncbi Stem-cell-based, tissue engineered tracheal replacement in a child: a 2-year follow-up study
    Martin J Elliott
    Department of Cardiothoracic Surgery, Great Ormond Street, Hospital for Children, London, UK
    Lancet 380:994-1000. 2012
    ..We describe the case of a child who received a stem-cell-based tracheal replacement and report findings after 2 years of follow-up...
  47. ncbi Third-generation biomedical materials
    Larry L Hench
    Department of Materials and the Tissue Engineering Centre, Imperial College of Science, Technology and Medicine, University of London, Prince Consort Road, London SW7 2BP, UK
    Science 295:1014-7. 2002
    ....
  48. pmc Microscale technologies for tissue engineering and biology
    Ali Khademhosseini
    Harvard Massachusetts Institute of Technology Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 103:2480-7. 2006
    Microscale technologies are emerging as powerful tools for tissue engineering and biological studies...
  49. pmc Similar properties of chondrocytes from osteoarthritis joints and mesenchymal stem cells from healthy donors for tissue engineering of articular cartilage
    Amilton M Fernandes
    The Norwegian Center for Stem Cell Research, University of Oslo, Oslo, Norway
    PLoS ONE 8:e62994. 2013
    ..We have isolated chondrocytes from OA joints, performed cell culture expansion and tissue engineering of cartilage using a disc-shaped alginate scaffold and chondrogenic differentiation medium...
  50. ncbi Capturing complex 3D tissue physiology in vitro
    Linda G Griffith
    Biological Engineering Division, Mechanical Engineering Department and Biotech Pharma Engineering Center, Massachusetts Institute of Technology, 16 429, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Nat Rev Mol Cell Biol 7:211-24. 2006
    The emergence of tissue engineering raises new possibilities for the study of complex physiological and pathophysiological processes in vitro...
  51. ncbi Hypoxia-mimicking mesoporous bioactive glass scaffolds with controllable cobalt ion release for bone tissue engineering
    Chengtie Wu
    State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, People s Republic of China
    Biomaterials 33:2076-85. 2012
    ..an important role in stimulating angiogenesis; there are, however, few studies to prepare hypoxia-mimicking tissue engineering scaffolds...
  52. ncbi On the mechanisms of biocompatibility
    David F Williams
    University of Liverpool, UK
    Biomaterials 29:2941-53. 2008
    ..This essay then turns its attention to the use of biomaterials in tissue engineering, sophisticated cell, drug and gene delivery systems and applications in biotechnology, and shows that here ..
  53. pmc Tissue engineering of functional articular cartilage: the current status
    Linda Kock
    Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands
    Cell Tissue Res 347:613-27. 2012
    ..In addition, the current status of tissue engineering of cartilage will be discussed, with the focus on extracellular matrix content, structure and its ..
  54. ncbi Tissue engineering and regenerative medicine: history, progress, and challenges
    Francois Berthiaume
    Department of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Annu Rev Chem Biomol Eng 2:403-30. 2011
    The past three decades have seen the emergence of an endeavor called tissue engineering and regenerative medicine in which scientists, engineers, and physicians apply tools from a variety of fields to construct biological substitutes that ..
  55. ncbi Osteogenesis and angiogenesis: the potential for engineering bone
    J M Kanczler
    Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Developmental Origins of Health and Disease, Institute of Developmental Sciences, University of Southampton, Southampton, SO16 6YD
    Eur Cell Mater 15:100-14. 2008
    ..this review, with consideration of how some of these key mechanisms can be combined with new developments in tissue engineering to enable repair and growth of skeletal fractures...
  56. ncbi Combining adult stem cells and polymeric devices for tissue engineering in infarcted myocardium
    Jean Pierre Karam
    LUNAM University, UMR S 1066, F 49933 Angers, France
    Biomaterials 33:5683-95. 2012
    ..Scaffold properties required for cardiac cell therapy are here discussed. New tissue engineering advances that may be implemented in combination with adult stem cells for myocardial infarction therapy are ..
  57. ncbi Silk protein fibroin from Antheraea mylitta for cardiac tissue engineering
    Chinmoy Patra
    Department of Cardiac Development and Remodelling, Max Planck Institute for Heart and Lung Research, Parkstrasse 1, 61231 Bad Nauheim, Germany
    Biomaterials 33:2673-80. 2012
    ..One possible solution to this problem is cardiac tissue engineering. Here, we have investigated the suitability of non-mulberry silk protein fibroin from Indian tropical tasar ..
  58. pmc High-fidelity tissue engineering of patient-specific auricles for reconstruction of pediatric microtia and other auricular deformities
    Alyssa J Reiffel
    Laboratory for Bioregenerative Medicine and Surgery, Division of Plastic Surgery, Weill Cornell Medical College, New York, New York, USA
    PLoS ONE 8:e56506. 2013
    ....
  59. ncbi The potential of human fetal mesenchymal stem cells for off-the-shelf bone tissue engineering application
    Zhi Yong Zhang
    Mechanical Engineering, Faculty of Engineering, National University of Singapore, Singapore
    Biomaterials 33:2656-72. 2012
    Mesenchymal stem cells (MSCs) have become one of the most promising cell sources for bone tissue engineering (BTE) applications...
  60. ncbi The extracellular matrix as a biologic scaffold material
    Stephen F Badylak
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Biomaterials 28:3587-93. 2007
    ....
  61. ncbi Vascularization is the key challenge in tissue engineering
    Esther C Novosel
    University of Stuttgart, Institute for Interfacial Engineering, Nobelstrasse 12, Stuttgart, Germany
    Adv Drug Deliv Rev 63:300-11. 2011
    ..Advantages and pitfalls of the approaches to create vascularized tissues in vitro are outlined and feasible future strategies are discussed...
  62. ncbi Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cells
    Janne L Simonsen
    Department of Endocrinology and Metabolism, University Hospital of Aarhus, DK 8000 Aarhus C, Denmark
    Nat Biotechnol 20:592-6. 2002
    ..These results suggest that ectopic expression of telomerase in hMSCs prevents senescence-associated impairment of osteoblast functions...
  63. pmc Biomimetic nanofibrous scaffolds for bone tissue engineering
    Jeremy M Holzwarth
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA
    Biomaterials 32:9622-9. 2011
    Bone tissue engineering is a highly interdisciplinary field that seeks to tackle the most challenging bone-related clinical issues. The major components of bone tissue engineering are the scaffold, cells, and growth factors...
  64. pmc Nanofibers and their applications in tissue engineering
    Rajesh Vasita
    Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Kanpur, Uttar Pradesh, India
    Int J Nanomedicine 1:15-30. 2006
    ..that mimic the architecture of tissue at the nanoscale is one of the major challenges in the field of tissue engineering. The development of nanofibers has greatly enhanced the scope for fabricating scaffolds that can potentially ..
  65. ncbi Can tissue engineering concepts advance tumor biology research?
    Dietmar W Hutmacher
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland 4059, Australia
    Trends Biotechnol 28:125-33. 2010
    Advances in tissue engineering have traditionally led to the design of scaffold- or matrix-based culture systems that better reflect the biological, physical and biochemical environment of the natural extracellular matrix...
  66. pmc Decellularized rhesus monkey kidney as a three-dimensional scaffold for renal tissue engineering
    Karina H Nakayama
    Center of Excellence in Translational Human Stem Cell Research, California National Primate Research Center, Davis, California 95616 8542, USA
    Tissue Eng Part A 16:2207-16. 2010
    ..Further, this study provides the initial steps in developing new regenerative medicine strategies for renal tissue engineering and repair.
  67. ncbi An alginate hydrogel matrix for the localised delivery of a fibroblast/keratinocyte co-culture
    Nicola C Hunt
    University of Birmingham, UK
    Biotechnol J 4:730-7. 2009
    ..These findings demonstrate that alginate hydrogel may be an effective delivery vehicle and scaffold for the healing of full-thickness skin wounds...
  68. ncbi Electrospun nanofibrous structure: a novel scaffold for tissue engineering
    Wan Ju Li
    School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, Pennsylvania 19104, USA
    J Biomed Mater Res 60:613-21. 2002
    ..This novel biodegradable scaffold has potential applications for tissue engineering based upon its unique architecture, which acts to support and guide cell growth.
  69. ncbi Chitosan scaffolds for osteochondral tissue regeneration
    Ander Abarrategi
    Instituto de Estudios Biofuncionales, Universidad Complutense, Madrid, Spain
    J Biomed Mater Res A 95:1132-41. 2010
    ..49 KDa), and lowest deacetylation degree (83%) shows a well structured subchondral bone and noticeable cartilaginous tissue regeneration, being it the best one of those tested for osteochondral defect regeneration...
  70. ncbi Whole-organ tissue engineering: decellularization and recellularization of three-dimensional matrix scaffolds
    Stephen F Badylak
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Annu Rev Biomed Eng 13:27-53. 2011
    ..Critical challenges and future directions are also discussed...
  71. ncbi Growth factor-loaded scaffolds for bone engineering
    J A Jansen
    Department of Periodontology and Biomaterials, University Medical Center, THK 117, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    J Control Release 101:127-36. 2005
    ..Nevertheless, orthotopic bone formation in a rabbit cranial defect model was stimulated in rhTGF-beta1- and rhBMP-2-loaded CaP cement and Ti-fiber mesh scaffolds compared with non-loaded implants...
  72. pmc Proangiogenic scaffolds as functional templates for cardiac tissue engineering
    Lauran R Madden
    Department of Bioengineering, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 107:15211-6. 2010
    ..This work establishes a foundation for spatially controlled cardiac tissue engineering by providing discrete compartments for cardiomyocytes and stroma in a scaffold that enhances vascularization ..
  73. ncbi The application of polyhydroxyalkanoates as tissue engineering materials
    Guo Qiang Chen
    Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China
    Biomaterials 26:6565-78. 2005
    ..making them attractive as biomaterials for applications in both conventional medical devices and tissue engineering. Over the past years, PHA, particularly poly 3-hydroxybutyrate (PHB), copolymers of 3-hydroxybutyrate and 3-..
  74. ncbi In vivo biocompatibility of ultra-short single-walled carbon nanotube/biodegradable polymer nanocomposites for bone tissue engineering
    Balaji Sitharaman
    Department of Bioengineering, Rice University, P O Box 1892, MS 142, Houston, TX 77251 1892, USA
    Bone 43:362-70. 2008
    Scaffolds play a pivotal role in the tissue engineering paradigm by providing temporary structural support, guiding cells to grow, assisting the transport of essential nutrients and waste products, and facilitating the formation of ..
  75. ncbi Electrospun materials as potential platforms for bone tissue engineering
    Jun Hyeog Jang
    Department of Biochemistry, Inha University College of Medicine, South Korea
    Adv Drug Deliv Rev 61:1065-83. 2009
    ..tools have been developed to mimic the native bone extracellular matrix for potential applications as tissue engineering scaffolds and ultimately to restore degenerated functions of the bone...
  76. ncbi Fabrication of pulsatile cardiac tissue grafts using a novel 3-dimensional cell sheet manipulation technique and temperature-responsive cell culture surfaces
    Tatsuya Shimizu
    Institute of Advanced Biomedical Engineering and Science, Tokyo Women s Medical University, Japan
    Circ Res 90:e40. 2002
    ..Cardiac tissue engineering is currently pursued utilizing conventional technology to fabricate 3-D biodegradable scaffolds as a ..
  77. ncbi Toward delivery of multiple growth factors in tissue engineering
    Fa Ming Chen
    Department of Periodontology and Oral Medicine, School of Stomatology, Fourth Military Medical University, Xi an 710032, Shaanxi, People s Republic of China
    Biomaterials 31:6279-308. 2010
    ..a tissue either in vitro or in vivo has led to the integration of a wide variety of growth factors (GFs) in tissue engineering strategies in an effort to mimic the natural microenvironments of tissue formation and repair...
  78. ncbi Hydrogel-beta-TCP scaffolds and stem cells for tissue engineering bone
    Christian Weinand
    Laboratory for Tissue Engineering and Organ Fabrication, Warren 11 1157, Massachusetts General Hospital, Harvard, Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Bone 38:555-63. 2006
    ..To overcome these limitations, we used a tissue engineering approach to create bone replacements in vitro, combining bone-marrow-derived differentiated mesenchymal stem ..
  79. ncbi Implantable applications of chitin and chitosan
    Eugene Khor
    Department of Chemistry, National University of Singapore, 3 Science Drive 3, Kent Ridge, Singapore 117543, Singapore
    Biomaterials 24:2339-49. 2003
    ..been shown to be useful as a wound dressing material, drug delivery vehicle and increasingly a candidate for tissue engineering. The promise for this biomaterial is vast and will continue to increase as the chemistry to extend its ..
  80. pmc Cartilage tissue engineering: towards a biomaterial-assisted mesenchymal stem cell therapy
    Claire Vinatier
    INSERM, U 791, LIOAD, Nantes, F 44042, France
    Curr Stem Cell Res Ther 4:318-29. 2009
    ..surgery, the lack of efficient modalities of treatment for large chondral defects has prompted research on tissue engineering combining chondrogenic cells, scaffold materials and environmental factors...
  81. ncbi Collagen scaffolds for tissue engineering
    Julie Glowacki
    Department of Orthopedic Surgery, Brigham and Women s Hospital, Boston, MA, USA
    Biopolymers 89:338-44. 2008
    There are two major approaches to tissue engineering for regeneration of tissues and organs. One involves cell-free materials and/or factors and one involves delivering cells to contribute to the regeneraion process...
  82. ncbi Porous scaffold design for tissue engineering
    Scott J Hollister
    Scaffold Tissue Engineering Group, Department of Biomedical Engineering, The University of Michigan, Ann Arbor, Michigan 41809, USA
    Nat Mater 4:518-24. 2005
    A paradigm shift is taking place in medicine from using synthetic implants and tissue grafts to a tissue engineering approach that uses degradable porous material scaffolds integrated with biological cells or molecules to regenerate ..
  83. pmc Engineering robust and functional vascular networks in vivo with human adult and cord blood-derived progenitor cells
    Juan M Melero-Martin
    Vascular Biology Program and Department of Surgery, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Circ Res 103:194-202. 2008
    The success of therapeutic vascularization and tissue engineering will rely on our ability to create vascular networks using human cells that can be obtained readily, can be expanded safely ex vivo, and can produce robust vasculogenic ..
  84. ncbi The development of a bioengineered organ germ method
    Kazuhisa Nakao
    Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, Noda, Chiba, 278 8510, Japan
    Nat Methods 4:227-30. 2007
    ..Our method provides a substantial advance in the development of bioengineered organ replacement strategies and regenerative therapies...
  85. ncbi Dose-dependent immunomodulatory effect of human stem cells from amniotic membrane: a comparison with human mesenchymal stem cells from adipose tissue
    Susanne Wolbank
    Red Cross Blood Transfusion Service of Upper Austria, Linz, Austria
    Tissue Eng 13:1173-83. 2007
    Bone marrow-derived mesenchymal stem cells (BMSCs) have been used for allogeneic application in tissue engineering but have certain drawbacks...
  86. ncbi Human adipose tissue-derived stem cells differentiate into endothelial cells in vitro and improve postnatal neovascularization in vivo
    Ying Cao
    Institute of Basic Medical Sciences and School of Basic Medicine, Center of Excellence in Tissue Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China
    Biochem Biophys Res Commun 332:370-9. 2005
    ..Because ADAS cells can be expanded in culture without obvious senescence for more than 20 population doublings, they may be a potential source of endothelial cells for cellular pro-angiogenic therapies...
  87. pmc Biomimetic materials for tissue engineering
    Peter X Ma
    Department of Biologic and Materials Sciences, The University of Michigan, Ann Arbor, MI 48109 1078, USA
    Adv Drug Deliv Rev 60:184-98. 2008
    b>Tissue engineering and regenerative medicine is an exciting research area that aims at regenerative alternatives to harvested tissues for transplantation...
  88. ncbi Cartilage engineering: a crucial combination of cells, biomaterials and biofactors
    Claire Vinatier
    INSERM, U 791, LIOAD, Nantes, F 44042, France
    Trends Biotechnol 27:307-14. 2009
    ..The lack of efficient modalities of treatment has prompted research into tissue engineering combining chondrogenic cells, scaffold materials and environmental factors...
  89. ncbi Stem cell differentiation to epidermal lineages on electrospun nanofibrous substrates for skin tissue engineering
    Guorui Jin
    Department of Mechanical Engineering, National University of Singapore, 2 Engineering Drive 3, Singapore 117576, Singapore
    Acta Biomater 7:3113-22. 2011
    ..MSC have been the focus of many tissue engineering studies, mainly because of their multipotential properties...
  90. pmc Growth factor delivery-based tissue engineering: general approaches and a review of recent developments
    Kangwon Lee
    School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02139, USA
    J R Soc Interface 8:153-70. 2011
    ..This review provides an overview of growth factor delivery in tissue engineering. Certain fundamental issues and design strategies relevant to the material carriers that are being actively ..
  91. ncbi Fibroblast growth factor receptors in in vitro and in vivo chondrogenesis: relating tissue engineering using adult mesenchymal stem cells to embryonic development
    Catharine A Hellingman
    Department of Otorhinolaryngology, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Tissue Eng Part A 16:545-56. 2010
    ..These results will help us understand the role of FGF signaling in chondrogenesis and find new tools to monitor and control chondrogenic differentiation...
  92. pmc Tissue-engineered vascular grafts transform into mature blood vessels via an inflammation-mediated process of vascular remodeling
    Jason D Roh
    Interdepartmental Program in Vascular Biology and Therapeutics, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 107:4669-74. 2010
    ..These findings suggest TEVGs transform into functional neovessels via an inflammatory process of vascular remodeling...
  93. ncbi Differential cartilaginous tissue formation by human synovial membrane, fat pad, meniscus cells and articular chondrocytes
    A Marsano
    Departments of Surgery and Research, University Hospital Basel, Basel, Switzerland
    Osteoarthritis Cartilage 15:48-58. 2007
    ..To identify an appropriate cell source for the generation of meniscus substitutes, among those which would be available by arthroscopy of injured knee joints...
  94. ncbi Rapid prototyping in tissue engineering: challenges and potential
    Wai Yee Yeong
    Rapid Prototyping Research Laboratory, Design Research Centre, School of Mechanical and Production Engineering, Nanyang Technological University, Singapore 639798
    Trends Biotechnol 22:643-52. 2004
    b>Tissue engineering aims to produce patient-specific biological substitutes in an attempt to circumvent the limitations of existing clinical treatments for damaged tissue or organs...
  95. ncbi Improved tissue-engineered bone regeneration by endothelial cell mediated vascularization
    Haiying Yu
    Department of Orthopaedic Surgery, Wayne State University, Detroit, MI 48201, USA
    Biomaterials 30:508-17. 2009
    ..These findings suggest that hybrid grafts have great potential for clinical use to treat large bone defects...
  96. ncbi Tissue engineering and the use of stem/progenitor cells for airway epithelium repair
    Godfried M Roomans
    School of Health and Medical Sciences, Orebro University, Orebro University Hospital, SE 70185 Orebro, Sweden
    Eur Cell Mater 19:284-99. 2010
    ..Clinical applications so far are few, but include subglottic stenosis, tracheomalacia, bronchiomalacia, and emphysema...
  97. ncbi A cell-laden microfluidic hydrogel
    Yibo Ling
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Lab Chip 7:756-62. 2007
    ..cells within the bulk material of microfluidic channels may be beneficial for applications ranging from tissue engineering to cell-based diagnostic assays...
  98. pmc Nanopattern-induced changes in morphology and motility of smooth muscle cells
    Evelyn K F Yim
    Department of Biomedical Engineering, The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Biomaterials 26:5405-13. 2005
    ..It is proposed that this nanoimprinting technology will provide a valuable platform for studies in cell-substrate interactions and for development of medical devices with nanoscale features...
  99. pmc Advances in musculoskeletal tissue engineering: moving towards therapy
    Carlo Alberto Rossi
    Surgery Unit, UCL Institute of Child Health and Great Ormond Street Hospital, London, United Kingdom
    Organogenesis 6:167-72. 2010
    ..In the last decade, tissue engineering looked at overcoming these problems by investigating alternative treatment options, i.e...
  100. ncbi Tissue-like self-assembly in cocultures of endothelial cells and osteoblasts and the formation of microcapillary-like structures on three-dimensional porous biomaterials
    Ronald E Unger
    Institute of Pathology, REPAIR Lab, Johannes Gutenberg University, Mainz 55101, Germany
    Biomaterials 28:3965-76. 2007
    ..Our results underline the necessity to take into account the in situ production of growth factors by invading mesenchymal cells in the regenerative niche...
  101. pmc Craniofacial tissue engineering by stem cells
    J J Mao
    Columbia University College of Dental Medicine and Biomedical Engineering, 630 W 168 St PH7 CDM, New York, NY 10032, USA
    J Dent Res 85:966-79. 2006
    Craniofacial tissue engineering promises the regeneration or de novo formation of dental, oral, and craniofacial structures lost to congenital anomalies, trauma, and diseases...

Research Grants90

  1. Training in Biomolecular and Tissue Engineering
    Farshid Guilak; Fiscal Year: 2007
    The Center for Biomolecular and Tissue Engineering (CBTE) at Duke University proposes a post-doctoral training program in the application of bioengineering principles to the design, manipulation, and quantitative characterization of ..
  2. BIOENGINEERING OF BLADDER TISSUES
    Anthony Atala; Fiscal Year: 2003
    ..Specific Aim 2: To determine the feasibility of attaining complete bladder replacement using tissue engineering techniques...
  3. Tissue Engineering Evaluation Criteria for Musculoskeletal Tissue Repair
    David Butler; Fiscal Year: 2007
    Abstract In the last two decades, tissue engineering in academia and industry has become an exciting, multidisciplinary field offering the potential to repair or regenerate injured and diseased musculoskeletal and craniofacial tissues ..
  4. A Biological Basis for Repair of the ACL
    Christopher Evans; Fiscal Year: 2009
    ..MRI, histology and immunohistochemistry will also be used to evaluate the healed ligament. These studies will advance our knowledge of the biology of the injured ACL and suggest novel, biologically-based approaches to healing. ..
  5. Transfer of IL-1Ra cDNA to Osteoarthritic Knee
    Christopher Evans; Fiscal Year: 2008
    ..abstract_text> ..
  6. Insulin Producing Cells from Amniotic Stem Cells for Diabetes Therapy
    Anthony Atala; Fiscal Year: 2009
    ..Successful development of an abundant source of transplantable insulin producing cells potentially would have a profound impact on the treatment of a major public health problem. ..
  7. TISSUE ENGINEERING OF THE TEMPOROMANDICULAR JOINT
    Anthony Ratcliffe; Fiscal Year: 2003
    ..The growth of tissues in vitro for in vivo transplantation and repair (tissue engineering) has recently been demonstrated to have immense potential...
  8. Chondrogenesis in Enzymatically Degradable Hydrogels
    JASON BURDICK; Fiscal Year: 2008
    ..support to the principle investigator in the area of advancing photopolymerizable hydrogels for cartilage tissue engineering in addition to support (4 years) as an independent faculty member to continue research in this field...
  9. Cartilage-Cartilage Adhesion by Photopolymerization
    Anthony Ratcliffe; Fiscal Year: 2004
    ..These in vitro studies will demonstrate whether this approach is feasible for testing in in vivo situations (Phase II application). ..
  10. 2008 Musculoskeletal Biology and Bioengineering Gordon Research Conference
    Farshid Guilak; Fiscal Year: 2008
    ..The meeting will consist of 9 separate sessions, consisting of invited speakers and selected attendees at various levels of career development. [unreadable] [unreadable] [unreadable] [unreadable]..
  11. Development of a Multi-phased Scaffold for Soft Tissue to Bone Integration
    Helen Lu; Fiscal Year: 2006
    ..abstract_text> ..
  12. Antimicrobial Gene Therapy
    George Huang; Fiscal Year: 2003
    ....
  13. "In Vitro Mechanical Stimulation to Enhance Tendon Repair"
    David Butler; Fiscal Year: 2009
    ..Using a functional tissue engineering or FTE roadmap with linked in vitro and in vivo studies, we will establish in vivo forces and displacements ..
  14. CERAMIC WHISKER REINFORCEMENT OF DENTAL COMPOSITE RESINS
    HUAKUN XU; Fiscal Year: 2002
    ....
  15. Human Tissue Engineered Matrix Constructs for Repair
    Anthony Ratcliffe; Fiscal Year: 2007
    ..A functional tissue engineering approach is being used to develop a device that will enhance the surgical repair of rotator cuff tendons...
  16. CONTROLLED RELEASE OF MACROMOLECULES
    Robert Langer; Fiscal Year: 2007
    ..Our best performing polymer-DNA formulations, identified in aims one and two, wilt be assayed in vivo in mice for 1) delivery efficiency, 2) specificity and biodistribution, and 3) complement activation and initial safety profile. ..
  17. Cell-specific Delivery of RNAi to Pulmonary Alveolar Macrophages in vivo
    Darrell Kotton; Fiscal Year: 2007
    ..Finally, the system is applied for in vivo knockdown of NF-kB signaling in mouse alveolar macrophages and the treatment of tobacco smoke- induced lung inflammation. [unreadable] [unreadable] [unreadable]..
  18. MR-Guided Delivery and Monitoring of Magnetocapsules Immunoprotecting Islet Cells
    JEFF BULTE; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  19. Neuropeptide Y Regulation of Peripheral Human Nociceptors and Pain
    Kenneth Hargreaves; Fiscal Year: 2007
    ..Moreover, our study population in South Texas permits secondary analyses of a potentially underserved population (predominantly Hispanic) that is at risk for caries-induced pulpal necrosis and pain. [unreadable] [unreadable]..
  20. Cardiac KATP Channels in Health and Disease
    Andre Terzic; Fiscal Year: 2007
    ..Thus, this proposal will provide an integrated understanding of cardiac KATP channels in metabolic signal decoding, stress adaptation, and their impact for clinical medicine. ..
  21. Derivation of Lung Epithelium from Bone Marrow
    Darrell Kotton; Fiscal Year: 2007
    ....
  22. Neuronal Biointerface: Micropatterned Lipid Bilayers
    Lance Kam; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  23. Bone Marrow Stromal Cells for Bladder Tissue Engineering
    Yuanyuan Zhang; Fiscal Year: 2006
    ..3.3) Evaluate extent of bladder regeneration at different time points through histology, contractility assays, and immunohistochemical staining. [unreadable] [unreadable] [unreadable]..
  24. Mesoporus Diamondlike Carbon Medical Device Membrane
    Roger Narayan; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  25. Automated Analysis of Learning and Memory for Neuro-Developmental Studies
    Michael Levin; Fiscal Year: 2010
    ..These three outcomes will result in the eventual development of novel therapeutics for brain diseases. ..
  26. Repair and regeneration in a novel animal model
    Cheng Ming Chuong; Fiscal Year: 2008
    unreadable] DESCRIPTION (provided by applicant): Regenerative medicine and tissue engineering have emerged as some of the most fascinating fields with potentially high clinical applications...
  27. Ultrasound Technologies for Tissue Engineering
    DENISE C contact HOCKING; Fiscal Year: 2010
    ..b>Tissue engineering is a potentially revolutionary approach for replacing or regenerating diseased or destroyed organs and ..
  28. Stem Cell Based Soft Tissue Reconstruction
    Jeremy J Mao; Fiscal Year: 2010
    ..of isolated meritorious attempts to engineer soft tissue by cell-based approaches, the effort level on soft tissue engineering lags far behind hard (bone) tissue engineering...
  29. Mechanical Feedback on Cell Structure and Signaling
    Shu Chien; Fiscal Year: 2010
    ..The results generated from these proposed studies will provide insight into the cellular adaptation mechanisms and homeostasis of biological functions in responses to stretch. ..
  30. HUMAN CTL-MEDIATED INJURY OF GRAFT ENDOTHELIAL CELLS
    JORDAN POBER; Fiscal Year: 2009
    ..These data will provide a rational basis for developing new, complementary strategies to further reduce the incidence and consequences of allograft rejection. ..
  31. The Role of Phosphatases in EC Mechanotransduction
    Shu Chien; Fiscal Year: 2009
    ....
  32. Prostaglandin Signaling in Wear Debris-induced Osteolysis
    REGIS O KEEFE; Fiscal Year: 2009
    ....
  33. The CXCR4-SDF-1 Axis in Metastatic Rhabdomyosarcoma
    Mariusz Ratajczak; Fiscal Year: 2009
    ..This work will be of relevance for designing strategies to block the SDF-1-CXCR4 axis to treat CXCR4-positive cancers. ..
  34. BIOSENSOR BIOCOMPATIBILITY
    William Reichert; Fiscal Year: 2008
    ..abstract_text> ..
  35. AUTOCRINE/PARACRINE GROWTH FACTORS & LUNG MORPHOGENESIS
    David Warburton; Fiscal Year: 2009
    ..Aim 4: To determine the role of tyrosine phosphorylation in protein-protein interaction and supra-molecular assembly of mSPRY2 with SHP2 and FRS2. Aim 5: To determine the functional importance of Shp2 in lung morphogenesis in vivo. ..
  36. Developing a CEST Reporter Gene (RMI)
    JEFF BULTE; Fiscal Year: 2008
    ..To achieve this goal, our aim is to synthesize novel, more efficient CEST reporter genes, and to detect double-labeled LRP/ARP transfected glioma cells and neural stem cells individually in live animals. [unreadable] [unreadable]..
  37. Biomimetic Nanofibrillar Scaffolds For Cartilage Tissue Engineering
    Anu Subramanian; Fiscal Year: 2008
    ..The regenerative capabilities of articular cartilage are very limited when injured or damaged by aging, tissue engineering concepts and methodologies that employ biocompatible matrices or scaffolds have the potential to help repair ..
  38. Microfluidics systems for formulation of contrast agents for molecular imaging
    Abraham Lee; Fiscal Year: 2008
    ..The further development of this microfluidic system, and resulting production of monodisperse contrast agents, will open several new avenues for high sensitivity targeted ultrasound imaging. [unreadable] [unreadable] [unreadable]..
  39. HEPATIC TISSUE ENGINEERING
    Martin Yarmush; Fiscal Year: 2006
    ..The proposed studies will also provide basic tools useful in the development of other engineered tissues and organs. ..
  40. Cartilage-Cartilage Adhesion by Photopolymerization
    Anthony Ratcliffe; Fiscal Year: 2006
    ..The successful outcome of this project will allow for submission to the FDA for product clearance (510k) or initiation of a clinical trial. ..
  41. Molecular Mechanism of Endothelial Migration Under Flow
    Shu Chien; Fiscal Year: 2004
    ..abstract_text> ..
  42. LONG TERM NERVE REGENERATION THROUGH COLLAGEN DEVICES
    Ioannis Yannas; Fiscal Year: 2001
    ..These data will be useful for all investigators studying the efficacy of devices for peripheral nerve regeneration. ..
  43. MR-Guided Delivery and Monitoring of Magnetocapsules Immunoprotecting Islet Cells
    JEFF BULTE; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  44. HEPARAN SULFATE IN CELLULAR IMMUNITY AND GRAFT REJECTION
    Jeffrey Platt; Fiscal Year: 2003
    ..These studies will use allo- and xenotransplant models. ..
  45. 5th Bone Fluid Flow Workshop
    MELISSA KNOTHE TATE; Fiscal Year: 2003
    ..Furthermore, implications of fluid flow for tissue engineering (Session 5) and patient care (Session 6) will be addressed...
  46. The Osteoblastic Monolayer as a 'Gatekeeper' in Bone
    MELISSA KNOTHE TATE; Fiscal Year: 2003
    ..This study is expected to provide insight into new strategies for treatment of bone diseases such as osteoporosis and osteoarthritis. ..
  47. Enhancing in vitro Cartilge Synthesis for Human Therapy
    Anthony Ratcliffe; Fiscal Year: 2004
    ..PROPOSED COMMERCIAL APPLICATION: Tissue engineering of cartilage in vitro, followed by transplantation for human therapy of articular surface defects.
  48. PATHOGENIC MECHANISMS OF VENOUS DISEASE
    Vincent Falanga; Fiscal Year: 2004
    ..The proposed studies should advance knowledge of the pathogenesis of venous ulceration and fibrosis. ..
  49. Cardiac Pacemaking and Conduction System Symposium
    ROBERT GOURDIE; Fiscal Year: 2004
    ..A website on the "cardiac pacemaking and conduction system" will be established at Medical University of South Carolina with content arising from work presented and published from the meeting. ..
  50. Patterning by Invasive Mesenchyme in the Embryonic Heart
    ROBERT GOURDIE; Fiscal Year: 2005
    ..abstract_text> ..
  51. CELLULAR AND MOLECULAR BASIS OF HIV BASED THROMBOCYTOPEN
    Mariusz Ratajczak; Fiscal Year: 2002
    ..In toto, the studies proposed in this grant will increase the knowledge about pathogenesis of AIDS associated thrombocytopenia and may lead to development of new strategies for its treatment of prevention. (End of Abstract) ..
  52. Functional Tissue Engineering of Articular Condyle
    Jeremy Mao; Fiscal Year: 2006
    ..The anticipated findings may have implications in the ultimate ex vivo fabrication of tissue-engineered articular condyles using cell-based regenerative approaches. ..
  53. CELL CYCLE OF CORNEAL ENDOTHELIUM
    Nancy Joyce; Fiscal Year: 2005
    ..Immunoprecipitation, Western blotting, RT-PCR, immunocytochemistry, flow cytometry, antisense methods, and expression of dominant-negative mutants will be used to accomplish the objectives of this proposal. ..
  54. MOLECULAR BASIS OF TOXICANT INDUCED VERTEBRAL ANOMALIES
    Rocky Tuan; Fiscal Year: 2001
    ....
  55. TMJ Bioengineering Conference
    MICHAEL DETAMORE; Fiscal Year: 2006
    ..A benchmark for contemporary knowledge of the TMJ will be assessed by 38 speakers in sessions on tissue engineering, biomechanics, biology and clinical treatment...
  56. GROWTH FACTORS AND EPIPHYSEAL CHONDROCYTE MATURATION
    REGIS O KEEFE; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  57. PERIPHERAL CANNABINOIDS AND NEUROGENIC INFLAMMATION
    Kenneth Hargreaves; Fiscal Year: 2002
    ..This knowledge base may provide a rationale for developing peripherally-selective cannabinoid analgesics with minimal CNS-mediated side-effect liability. ..
  58. Novel Mechanism of Induction of Eye Tissue: Katp Channel Modulation
    Michael Levin; Fiscal Year: 2010
    ....
  59. A Novel Engineered Composite Construct for Articular Cartilage Repair
    Anthony Ratcliffe; Fiscal Year: 2008
    ..The results obtained will provide the data necessary for a regulatory submission to the FDA to market the product. [unreadable] [unreadable] [unreadable] [unreadable]..
  60. Mechanisms of Marrow-Derived Stem Cell Remodeling of Aged Emphysematous Lungs
    Daniel Weiss; Fiscal Year: 2008
    ..abstract_text> ..
  61. LONG TERM NERVE REGENERATION THROUGH COLLAGEN DEVICES
    Ioannis Yannas; Fiscal Year: 2002
    ..These data will be useful for all investigators studying the efficacy of devices for peripheral nerve regeneration. ..
  62. Mechanical and Molecular Bases of Endothelial Remodeling
    Shu Chien; Fiscal Year: 2009
    ..abstract_text> ..
  63. Cannabinoid Modulation of Capsaicin-Sensitive Nociceptors
    Kenneth M Hargreaves; Fiscal Year: 2010
    ..Second, identification of cannabinoid modulation of pain via TRPchannels provides a rationale for a novel class of analgesics that are devoid of classical cannabinoid side effects. ..
  64. MICROCHIP DRUG DELIVERY SYSTEM
    Robert Langer; Fiscal Year: 2003
    ..abstract_text> ..
  65. Development of the Mouse Cochlea Database
    PETER ALAN SANTI; Fiscal Year: 2010
    ..abstract_text> ..
  66. FIBRONECTIN DEPOSITION AND PULMONARY FIBROSIS
    DENISE HOCKING; Fiscal Year: 2002
    ....
  67. In Vitro Synthesis of Fibrosis Genesis
    CELESTE NELSON; Fiscal Year: 2008
    ..We present here a three-dimensional, microlithography-based model that can be used to break down the key steps involved in the earliest stages of fibrosis genesis. [unreadable] [unreadable] [unreadable]..
  68. Lung epithelial and vascular morphogenesis
    David Warburton; Fiscal Year: 2006
    ..abstract_text> ..
  69. Restoration of Skin Structure and Function Post-Wounding
    ROBERT GOURDIE; Fiscal Year: 2006
    ..It is FSR's overall objective to develop its peptide into a pharmaceutically acceptable topical agent for application to surgical and non-surgical skin wounds in humans. [unreadable] [unreadable] [unreadable]..
  70. The Role of Ductin in Embryonic Morphogenesis
    Michael Levin; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  71. Stem-Cell Based Tissue Engineering in Regenerative Medicine Conference
    Jeremy Mao; Fiscal Year: 2006
    ..provided by applicant): This is a conference grant application (R13) requesting funding for Stem Cell-Based Tissue Engineering in Regenerative Medicine Conference as the central theme of the 24th Society for Physical Regulation in ..
  72. Robotic Simulation: Tissue Function with In Vivo Motions
    David Butler; Fiscal Year: 2007
    ..These technologies will serve as a platform for studying injury, repair and reconstruction in the knee and other joints and to develop functional tissue engineering parameters. [unreadable] [unreadable] [unreadable]
  73. Neuroprotection with serpins during cardiac surgery
    Richard A Jonas; Fiscal Year: 2010
    ..The final phase will study mechanisms of vascular protection afforded by aprotinin. The proposed study has the potential to reduce the risk of brain injury in children and adults undergoing heart surgery. ..
  74. 3D Woven Scaffolds for Tissue Engineering
    Farshid Guilak; Fiscal Year: 2003
    b>Tissue engineering is a relatively new but rapidly growing field that has sought to use combinations of implanted cells, biomaterials, and biologically active molecules to repair or regenerate injured or diseased tissues...
  75. Cell phenotype-controlled mechanical signaling of MSCs
    David Butler; Fiscal Year: 2004
    Functional tissue engineering (FTE) seeks to enhance tissue engineered (TE) repairs using in vivo loads and strains from normal tissues to condition the constructs to their mechanical environment prior to surgery...
  76. The influence of ischemic microenvironment and stem cell differentiation
    Randall Lee; Fiscal Year: 2008
    ..unreadable] Specific aim 2: To test the hypothesis that the microenvironment influences SC differentiation, angiogenesis and LV remodeling. [unreadable] [unreadable] [unreadable]..
  77. Dental Implant Science & Tech Transfer Satellite Meeting
    Jack Lemons; Fiscal Year: 2004
    ..Both organizations, IRG and WCOI-6 have approved the collaborations. Experience has been that 400 or more implant dentists attend the WCOI-6 and i00 or more researchers attend the IRG satellite sessions. ..
  78. Novel Cellular Lifespan Extension for Tissue Engineering
    Laura Niklason; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Vascular tissue engineering is a rapidly accelerating area...
  79. Epidemiology of Connective Tissue Progenitor Populations
    George Muschler; Fiscal Year: 2006
    ..CTPs are also central to efforts in Orthopaedic Tissue Engineering, both as tools for cell therapy and as targets for local and systemic therapy...
  80. Regulation of osteoblast function by endothelin-1
    Gregory Clines; Fiscal Year: 2006
    ..Since sex steroids modulate the effects of ETA blockade, eugonadal and castrated mice will be analyzed for gross anatomic and histologic bone developmental abnormalities. [unreadable] [unreadable]..
  81. OPTIMIZING BONE MARROW AS A BONE GRAFT
    George Muschler; Fiscal Year: 2005
    The Broad Aim of this proposal is to advance the field of Bone Tissue Engineering by defining general principles and techniques that can be applied to the rapid harvest and intra- operative transplantation of bone marrow derived ..
  82. Optimizing Assays of Human Stem Cells in Bone Marrow
    George Muschler; Fiscal Year: 2007
    ..abstract_text> ..
  83. CARDIAC GRAFTS--SKELETAL MYOBLASTS
    CHARLES MURRY; Fiscal Year: 2005
    ....
  84. TISSUE ENGINEERING OF BLOOD VESSEL SUBSTITUTES
    Joseph Vacanti; Fiscal Year: 2002
    ..While the preliminary studies have been encouraging, information concerning the cell biology of tissue engineered conduits is scant. ..
  85. Arteries Engineered from Porcine Vascular Cells
    Laura Niklason; Fiscal Year: 2005
    ..The tissue engineering of autologous vessels for these patients could have an enormous impact on therapy for cardiovascular disease...
  86. Polymer/Ceramic Composites for Tissue Engineering
    Cato Laurencin; Fiscal Year: 2009
    b>Tissue engineering has developed into a truly interdisciplinary field offering promises to revitalize or replace damaged or lost human tissue/organs...
  87. SPINAL BENDING MOTIONS FOR PREVENTING DISC DEGENERATION
    Adam Hsieh; Fiscal Year: 2003
    ..These regimens will then be tested experimentally to determine the effects on biosynthesis and apoptosis. ..
  88. Intermediate filament control of neuronal mechanics
    Sanjay Kumar; Fiscal Year: 2005
    ..abstract_text> ..
  89. Effects of Microengineered Interactions on Liver-Specific Gene Expression
    Alexander Revzin; Fiscal Year: 2007
    ..In the future, proposed microfabricated devices will be used to induce differentiation of human ESC toward hepatic lineage. [unreadable] [unreadable] [unreadable]..
  90. Novel Biodegradable Polymers for Tissue Engineering
    Cato Laurencin; Fiscal Year: 2004
    ..Thus, the objective of this project is to use a tissue engineering approach to develop new materials as practical alternatives to current bone repair materials...