waist hip ratio

Summary

Summary: The waist circumference measurement divided by the hip circumference measurement. For both men and women, a waist-to-hip ratio (WHR) of 1.0 or higher is considered "at risk" for undesirable health consequences, such as heart disease and ailments associated with OVERWEIGHT. A healthy WHR is 0.90 or less for men, and 0.80 or less for women. (National Center for Chronic Disease Prevention and Health Promotion, 2004)

Top Publications

  1. ncbi Impact of obesity and body fat distribution on cardiovascular risk factors in Hong Kong Chinese
    G Neil Thomas
    Department of Community Medicine, University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong
    Obes Res 12:1805-13. 2004
  2. ncbi Measures of adiposity in the identification of metabolic abnormalities in elderly men
    S Goya Wannamethee
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, United Kingdom
    Am J Clin Nutr 81:1313-21. 2005
  3. ncbi Metabolic obesity: the paradox between visceral and subcutaneous fat
    Osama Hamdy
    Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Curr Diabetes Rev 2:367-73. 2006
  4. ncbi Comparison of abdominal adiposity and overall obesity in predicting risk of type 2 diabetes among men
    Youfa Wang
    Department of Human Nutrition and Division of Epidemiology and Biostatistics, University of Illinois at Chicago, USA
    Am J Clin Nutr 81:555-63. 2005
  5. ncbi General and abdominal adiposity and risk of death in Europe
    T Pischon
    Department of Epidemiology, German Institute of Human Nutrition, Potsdam Rehbruecke, Germany
    N Engl J Med 359:2105-20. 2008
  6. ncbi Are waist circumference and body mass index independently associated with cardiovascular disease risk in Chinese adults?
    Rachel P Wildman
    Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA
    Am J Clin Nutr 82:1195-202. 2005
  7. ncbi A 24-year follow-up of body mass index and cerebral atrophy
    D Gustafson
    Department of Family and Community Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
    Neurology 63:1876-81. 2004
  8. ncbi Metabolic syndrome: from global epidemiology to individualized medicine
    J A Batsis
    Division of Primary Care Internal Medicine, Department of Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Clin Pharmacol Ther 82:509-24. 2007
  9. ncbi Increased activation of nuclear factor kappaB triggers inflammation and insulin resistance in polycystic ovary syndrome
    Frank Gonzalez
    Department of Obstetrics and Gynecology, MetroHealth Medical Center, Hamann S4 44, 2500 MetroHealth Drive, Cleveland, OH 44109, USA
    J Clin Endocrinol Metab 91:1508-12. 2006
  10. ncbi Prevalence of the metabolic syndrome defined by the International Diabetes Federation among adults in the U.S
    Earl S Ford
    Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Diabetes Care 28:2745-9. 2005

Detail Information

Publications211 found, 100 shown here

  1. ncbi Impact of obesity and body fat distribution on cardiovascular risk factors in Hong Kong Chinese
    G Neil Thomas
    Department of Community Medicine, University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong
    Obes Res 12:1805-13. 2004
    ..We report the relative associations between general and central obesity and risk factors in 2893 Chinese subjects recruited from the Hong Kong population...
  2. ncbi Measures of adiposity in the identification of metabolic abnormalities in elderly men
    S Goya Wannamethee
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, United Kingdom
    Am J Clin Nutr 81:1313-21. 2005
    ..Body mass index (BMI; in kg/m(2)) is considered a poor indicator of overall and abdominal obesity in the elderly...
  3. ncbi Metabolic obesity: the paradox between visceral and subcutaneous fat
    Osama Hamdy
    Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Curr Diabetes Rev 2:367-73. 2006
    ..The term "Metabolic Obesity", in reference to visceral fat accumulation in either lean or obese individuals may identify those at risk for cardiovascular disease better than the currently used definitions of obesity...
  4. ncbi Comparison of abdominal adiposity and overall obesity in predicting risk of type 2 diabetes among men
    Youfa Wang
    Department of Human Nutrition and Division of Epidemiology and Biostatistics, University of Illinois at Chicago, USA
    Am J Clin Nutr 81:555-63. 2005
    ..However, few studies have compared the predictive power of overall obesity with that of central obesity. The cutoffs for waist circumference (WC) and waist-to-hip ratio (WHR) as measures of abdominal adiposity remain controversial...
  5. ncbi General and abdominal adiposity and risk of death in Europe
    T Pischon
    Department of Epidemiology, German Institute of Human Nutrition, Potsdam Rehbruecke, Germany
    N Engl J Med 359:2105-20. 2008
    ....
  6. ncbi Are waist circumference and body mass index independently associated with cardiovascular disease risk in Chinese adults?
    Rachel P Wildman
    Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA
    Am J Clin Nutr 82:1195-202. 2005
    ..In Western populations, waist circumference (WC) is more predictive of cardiovascular disease (CVD) risk than is body mass index (BMI). It is unclear whether the same is true in Asian populations...
  7. ncbi A 24-year follow-up of body mass index and cerebral atrophy
    D Gustafson
    Department of Family and Community Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
    Neurology 63:1876-81. 2004
    ..To investigate the longitudinal relationship between body mass index (BMI), a major vascular risk factor, and cerebral atrophy, a marker of neurodegeneration, in a population-based sample of middle-aged women...
  8. ncbi Metabolic syndrome: from global epidemiology to individualized medicine
    J A Batsis
    Division of Primary Care Internal Medicine, Department of Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Clin Pharmacol Ther 82:509-24. 2007
    ..We outline the existing controversies that surround MetS and discuss the role of lifestyle, pharmacological, surgical, and novel approaches in its management...
  9. ncbi Increased activation of nuclear factor kappaB triggers inflammation and insulin resistance in polycystic ovary syndrome
    Frank Gonzalez
    Department of Obstetrics and Gynecology, MetroHealth Medical Center, Hamann S4 44, 2500 MetroHealth Drive, Cleveland, OH 44109, USA
    J Clin Endocrinol Metab 91:1508-12. 2006
    ..Insulin resistance and chronic low level inflammation are often present in women with polycystic ovary syndrome (PCOS)...
  10. ncbi Prevalence of the metabolic syndrome defined by the International Diabetes Federation among adults in the U.S
    Earl S Ford
    Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Diabetes Care 28:2745-9. 2005
    ..S. adults and to compare it with the prevalence estimated using the definition of the National Cholesterol Education Program (NCEP)...
  11. ncbi Plasma visfatin concentrations and fat depot-specific mRNA expression in humans
    Janin Berndt
    University of Leipzig, D 04103 Leipzig, Germany
    Diabetes 54:2911-6. 2005
    ..In addition, we did not find differences in visfatin mRNA expression between visceral and subcutaneous adipose tissue in humans...
  12. ncbi Waist circumference values are increasing beyond those expected from BMI increases
    Mai A Elobeid
    Section of Statistical Genetics, Department of Biostatistics, Ryals Public Health Building, Suite 414, University of Alabama, 1665 University Boulevard, Birmingham, AL 35294, USA
    Obesity (Silver Spring) 15:2380-3. 2007
    ..S. population-based data from 1959 to 2004 and to investigate the trend in WC over calendar time...
  13. ncbi Elevated plasma level of visfatin/pre-B cell colony-enhancing factor in patients with type 2 diabetes mellitus
    Miao Pei Chen
    Department of Clinical Research, Pingtung Christian Hospital, Pingtung, 90000 Taiwan
    J Clin Endocrinol Metab 91:295-9. 2006
    ..Originally isolated as a secreted factor that promotes the growth of B cell precursors and recently found to act as an insulin analog on the insulin receptor, its pathophysiological role in humans remains largely unknown...
  14. ncbi Diabetes and hypertension increases in a society with abdominal obesity: results of the Mexican National Health Survey 2000
    Claudia P Sánchez-Castillo
    Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Direccion de Nutricion, Departamento de Fisiologia de la Nutricion, Tlalpan, Mexico
    Public Health Nutr 8:53-60. 2005
    ..To determine the prevalences of overweight, obesity, type 2 diabetes mellitus (DM) and hypertension (HT) in the Mexican population and compare them with those of a previous Mexican urban survey and an American survey...
  15. ncbi Interactive effect of obesity indexes on cognition
    Seul Ki Jeong
    Department of Neurology, Chonbuk National University School of Medicine, Jeonju, Republic of Korea
    Dement Geriatr Cogn Disord 19:91-6. 2005
    ..Interaction terms with abdominal obesity for BMI increase were significant (p = 0.007). Obesity was associated with poor cognition, and obesity indexes must be carefully considered to reveal this relationship...
  16. ncbi Body mass index and hip and thigh circumferences are negatively associated with visceral adipose tissue after control for waist circumference
    Jennifer L Kuk
    School of Kinesiology and Health Studies, Queen s University, Kingston, Ontario, Canada
    Am J Clin Nutr 85:1540-4. 2007
    ....
  17. ncbi Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case-control study
    Salim Yusuf
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada
    Lancet 366:1640-9. 2005
    ..We aimed to assess whether markers of obesity, especially waist-to-hip ratio, would be stronger indicators of myocardial infarction than body-mass index (BMI), the conventional measure...
  18. ncbi Accuracy of anthropometric indicators of obesity to predict cardiovascular risk
    Harald J Schneider
    Institute of Clinical Psychology and Psychotherapy, Technical University, Dresden, Germany
    J Clin Endocrinol Metab 92:589-94. 2007
    ..However, more recently, waist to hip ratio (WHR) or waist circumference (WC) as more sensitive measures for visceral obesity have been proposed to be more indicative of cardiovascular risk...
  19. ncbi Association between common polymorphisms of the proopiomelanocortin gene and body fat distribution: a family study
    Michelle Baker
    Institute of Human Genetics, Central Parkway, Newcastle NE1 3BZ, UK
    Diabetes 54:2492-6. 2005
    ..These data show that genetic variants at the POMC locus influence body fat distribution within the normal range, suggesting a novel role for POMC in metabolic regulation...
  20. ncbi Body mass index, calcium intake, and physical activity affect calcaneal ultrasound in healthy Greek males in an age-dependent and parameter-specific manner
    Eirini Babaroutsi
    Laboratory of Nutrition and Clinical Dietetics, Department of Nutrition and Dietetics, Harokopio University, 70 El Venizelou Avenue, 17671, Athens, Greece
    J Bone Miner Metab 23:157-66. 2005
    ..In conclusion, body size, dietary calcium intake, and physical activity patterns seem to inconsistently and age-dependently influence heel QUS among healthy Greek males in a parameter-specific manner...
  21. pmc Prescreening tools for diabetes and obesity-associated dyslipidaemia: comparing BMI, waist and waist hip ratio. The D.E.S.I.R. Study
    B Balkau
    INSERM, U258, Villejuif, France
    Eur J Clin Nutr 60:295-304. 2006
    To compare the sensitivities of BMI, waist circumference and waist hip ratio (WHR) in identifying subjects who should be screened for diabetes and/or for obesity-associated dyslipidaemia.
  22. ncbi Association of proopiomelanocortin gene polymorphisms with obesity in the IRAS family study
    Beth S Sutton
    Department of Biochemistry, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Obes Res 13:1491-8. 2005
    ..These results support the hypothesis that POMC contributes genetically to the development of obesity...
  23. ncbi Plasma retinol-binding protein-4 concentrations are elevated in human subjects with impaired glucose tolerance and type 2 diabetes
    Young Min Cho
    Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, 110 744, Korea
    Diabetes Care 29:2457-61. 2006
    ..Here, we examined the relation between plasma RBP4 concentrations and various metabolic parameters in humans...
  24. ncbi Distribution of body fat and risk of coronary heart disease in men and women
    Dexter Canoy
    Northwest Institute for Bio Health Informatics, The University of Manchester, Manchester, UK
    Curr Opin Cardiol 23:591-8. 2008
    ..This review aims to assess current findings on the prospective association between body fat distribution measures and coronary heart disease in men and women...
  25. doi BMI compared with central obesity indicators in relation to diabetes and hypertension in Asians
    R Nyamdorj
    Obesity (Silver Spring) 16:1622-35. 2008
    ..To compare BMI with waist circumference (WC), waist-to-hip ratio (WHR), and waist-to-stature ratio (WSR) in association with diabetes or hypertension...
  26. ncbi Enlarged waist combined with elevated triglycerides is a strong predictor of accelerated atherogenesis and related cardiovascular mortality in postmenopausal women
    Laszlo B Tanko
    Center for Clinical and Basic Research, Ballerup Byvej 222, 2750 Ballerup, Denmark
    Circulation 111:1883-90. 2005
    ..Whether EWET offers superior disease and event prediction in postmenopausal women, however, remains unknown...
  27. ncbi The importance of waist circumference in the definition of metabolic syndrome: prospective analyses of mortality in men
    Peter T Katzmarzyk
    School of Physical and Health Education, Queen s University, Kingston, ON K7L 3N6, Canada
    Diabetes Care 29:404-9. 2006
    ....
  28. ncbi Abdominal adiposity and mortality in Chinese women
    Xianglan Zhang
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN 37232 8300, USA
    Arch Intern Med 167:886-92. 2007
    ..Increased abdominal adiposity has been linked to an increase in mortality in populations where many are overweight or obese; it is unclear whether the same is true in relatively lean populations...
  29. ncbi Life-course origins of social inequalities in metabolic risk in the population of a developing country
    C M Schooling
    Department of Community Medicine and School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    Am J Epidemiol 167:419-28. 2008
    ....
  30. ncbi Associations between prenatal and infancy weight gain and BMI, fat mass, and fat distribution in young adulthood: a prospective cohort study in males and females born very preterm
    Anne M Euser
    Department of Clinical Epidemiology, Leiden University Medical Center, Netherlands
    Am J Clin Nutr 81:480-7. 2005
    ..Increasing evidence indicates that adult body composition is associated with prenatal and infancy weight gain, but the relative importance of different time periods has not been elucidated...
  31. ncbi A farewell to body-mass index?
    Charlotte Kragelund
    Department of Medicine, Akershus University Hospital, NO 1478 Lørenskog, Norway
    Lancet 366:1589-91. 2005
  32. ncbi Correlates of C-reactive protein levels in young adults: a population-based cohort study of 3827 subjects in Brazil
    A Nazmi
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48104, USA
    Braz J Med Biol Res 41:357-67. 2008
    ..We conclude that both distal (socio-demographic) and proximal (anthropometric and behavioral) factors exert strong effects on C-reactive protein levels and that the former are mediated to some degree by the latter...
  33. ncbi Birth weight; postnatal, infant, and childhood growth; and obesity in young adulthood: evidence from the Barry Caerphilly Growth Study
    Anne McCarthy
    Department of Social Medicine, University of Bristol, Bristol, United Kingdom
    Am J Clin Nutr 86:907-13. 2007
    ..Birth weight has been shown to be positively associated with adult obesity, but relatively few studies have examined the associations with growth in specific periods of early childhood...
  34. ncbi Independent and inverse association of hip circumference with metabolic risk factors in Tehranian adult men
    Ahmad Esmaillzadeh
    Endocrine Research Center, Shaheed Beheshti University of Medical Sciences, P O Box 19395 4763, Tehran, I R Iran
    Prev Med 42:354-7. 2006
    ..To evaluate the relationship between hip circumference and metabolic risk factors in an urban adult population of Tehranian men...
  35. ncbi Dietary fiber intake and risk factors for cardiovascular disease in French adults
    Denis Lairon
    INSERM, U476, and INRA 1260, Universite de la Mediterranee, Marseille, France
    Am J Clin Nutr 82:1185-94. 2005
    ..Increased consumption of dietary fiber is widely recommended to maintain or improve health, but knowledge of the relation between dietary fiber sources and cardiovascular disease risk factors is limited...
  36. ncbi Bone mineral density of the spine and femur in healthy Saudis
    M Salleh M Ardawi
    Saudi Osteoporosis Research Group, Jeddah, Saudi Arabia
    Osteoporos Int 16:43-55. 2005
    ..0% in females and 0.8% in males). The present study underscores the importance of using population-specific reference values for BMD measurements to avoid overdiagnosis and/or underdiagnosis of osteoporosis...
  37. ncbi Estimation of truncal adiposity using waist circumference or the sum of trunk skinfolds: a pilot study for insulin resistance screening in hirsute patients with or without polycystic ovary syndrome
    Mariana Toscani
    Gynecological Endocrinology Unit, Division of Endocrinology, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil
    Metabolism 56:992-7. 2007
    ..Waist circumference and the sum of trunk skinfolds represent accurate methods to estimate truncal adiposity, but waist circumference measurement seems to be the simplest method of clinical screening for IR in hirsute women...
  38. ncbi Common genetic variation near MC4R is associated with waist circumference and insulin resistance
    John C Chambers
    Department of Epidemiology and Public Health, Imperial College London, Norfolk Pl, London W2 1PG, UK
    Nat Genet 40:716-8. 2008
    ..Homozygotes for the risk allele of rs12970134 have approximately 2 cm increased waist circumference. Common genetic variation near MC4R is associated with risk of adiposity and insulin resistance...
  39. ncbi Prevalence of obesity, central obesity and the associated factors in urban population aged 20-70 years, in the north of Iran: a population-based study and regression approach
    K O Hajian-Tilaki
    Department of Social Medicine and Health, Babol Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
    Obes Rev 8:3-10. 2007
    ..Therefore, a community-based multiple strategies are required to combat with increasing rate of obesity and its subsequent complications such as diabetes, coronary artery disease, hypertension and osteoarthritis...
  40. pmc Waist circumference correlates with metabolic syndrome indicators better than percentage fat
    Wei Shen
    Obesity Research Center, St Luke s Roosevelt Hospital, New York, NY 10025, USA
    Obesity (Silver Spring) 14:727-36. 2006
    ....
  41. ncbi Comparison of body mass index, waist circumference, and waist/hip ratio in predicting incident diabetes: a meta-analysis
    Gabriela Vazquez
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 South Second Street, Minneapolis, MN 55454, USA
    Epidemiol Rev 29:115-28. 2007
    ..Although the clinical perspective focusing on central obesity is appealing, further research is needed to determine the usefulness of waist circumference or waist/hip ratio over body mass index...
  42. ncbi Waist/height ratio as a better predictor of type 2 diabetes compared to body mass index in Tehranian adult men--a 3.6-year prospective study
    F Hadaegh
    Endocrine Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
    Exp Clin Endocrinol Diabetes 114:310-5. 2006
    ..To investigate whether central obesity variables are more important than general obesity variables in predicting the incidence of type 2 diabetes in Iranians...
  43. ncbi Risk factors for acute myocardial infarction in Latin America: the INTERHEART Latin American study
    Fernando Lanas
    Facultad de Medicina, Universidad de La Frontera M, Montt 112 Temuco, Chile
    Circulation 115:1067-74. 2007
    ..Current knowledge of the impact of cardiovascular risk factors in Latin America is limited...
  44. ncbi Population comparison of two clinical approaches to the metabolic syndrome: implications of the new International Diabetes Federation consensus definition
    Robert J Adams
    The Health Observatory, University of Adelaide, Department of Medicine, Queen Elizabeth Hospital Campus, Australia
    Diabetes Care 28:2777-9. 2005
  45. ncbi BMI vs. waist circumference for identifying vascular risk
    Matthew S Freiberg
    Center for Research on Health Care, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Obesity (Silver Spring) 16:463-9. 2008
    ..0 and 34.9 kg/m(2). We investigated the relative contributions of BMI and WC toward identifying risk of adverse vascular events in a community-based sample...
  46. ncbi The effects of uncoupling protein 3 haplotypes on obesity phenotypes and very low-energy diet-induced changes among overweight Korean female subjects
    Min Ho Cha
    Department of Medical Research, Korea Institute of Oriental Medicine, Daejon 305 811, and School of Life Sciences and Biotechnology, Korea University, Seoul 136 701, South Korea
    Metabolism 55:578-86. 2006
    ..Among the body components, changes in body fat mass were significantly associated with ht1 [CGTACC] (P=.028), but changes in body fat-free mass were not significantly associated with the UCP-3 polymorphism...
  47. ncbi Correspondence between the adult treatment panel III criteria for metabolic syndrome and insulin resistance
    Justo Sierra-Johnson
    Division of Nephrology and Hypertension, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Diabetes Care 29:668-72. 2006
    ....
  48. ncbi Prevalence of the metabolic syndrome among Italian adults according to ATP III definition
    Roberto Miccoli
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Nutr Metab Cardiovasc Dis 15:250-4. 2005
    ..To evaluate the prevalence of the metabolic syndrome as defined by NCEP ATP III criteria in an Italian cohort of adult subjects...
  49. pmc Anthropometric predictors of incident type 2 diabetes mellitus in Iranian women
    Farzad Hadaegh
    Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
    Ann Saudi Med 29:194-200. 2009
    ..Studies have shown a strong association between excess weight and risk of incident diabetes in Iranian women. Therefore, we investigated anthropometric indices in the prediction of diabetes in Iranian women...
  50. ncbi BMI compared with central obesity indicators as a predictor of diabetes incidence in Mauritius
    Regzedmaa Nyamdorj
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Obesity (Silver Spring) 17:342-8. 2009
    ..05). The relation of BMI with the development of diabetes was as strong as that for indicators of central obesity in this study population...
  51. ncbi Impaired subcutaneous adipocyte lipogenesis is associated with systemic insulin resistance and increased apolipoprotein B/AI ratio in men and women
    J Hoffstedt
    Department of Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden
    J Intern Med 262:131-9. 2007
    ..To study the association between subcutaneous fat cell lipogenesis and components of the metabolic syndrome (systemic insulin resistance, dyslipidaemia and hypertension)...
  52. ncbi Asymmetrical dimethylarginine, inflammatory and metabolic parameters in women with polycystic ovary syndrome before and after metformin treatment
    Dennis Heutling
    Department of Endocrinology and Metabolism, Otto von Guericke University, D 39120 Magdeburg, Germany
    J Clin Endocrinol Metab 93:82-90. 2008
    ..The endogenous nitric oxide synthase inhibitor asymmetrical dimethyl-L-arginine (ADMA) is associated with atherosclerosis and represents an independent marker for cardiovascular morbidity and mortality...
  53. ncbi Does the relationship between waist circumference, morbidity and mortality depend on measurement protocol for waist circumference?
    R Ross
    School of Kinesiology and Health Studies, Queen s University, Kingston, ON, Canada
    Obes Rev 9:312-25. 2008
    ..Our findings suggest that WC measurement protocol has no substantial influence on the association between WC, all-cause and CVD mortality, CVD and diabetes...
  54. ncbi Circulating oxidized LDL is associated with increased waist circumference independent of body mass index in men and women
    Tanja Weinbrenner
    Department of Public Health, Universidad Miguel Hernandez, Campus San Juan, Alicante, Spain
    Am J Clin Nutr 83:30-5; quiz 181-2. 2006
    ..Obesity is associated with oxidative stress, and the oxidation of LDL is thought to play a crucial role in the generation of atherosclerotic lesions...
  55. ncbi Plasma total homocysteine level and its association with carotid intima-media thickness in obesity
    O Uysal
    Internal Medicine, Medical Faculty, Trakya University, Edirne, Turkey
    J Endocrinol Invest 28:928-34. 2005
    ..Elevated plasma concentrations of total homocysteine (tHcy) and obesity are risk factors for cardiovascular disease. The relationship between hyperhomocysteinemia and obesity has not been totally elucidated...
  56. ncbi In addition to obesity and insulin resistance, microalbuminuria and diminished insulin secretion are linked with the metabolic syndrome in community-dwelling nondiabetic Taiwanese subjects
    Yi Ching Yang
    Department of Family Medicine, College of Medicine, National Cheng Kung University, 138 Sheng Li Rd, Tainan 704, Taiwan, ROC
    Diabetes Res Clin Pract 76:102-10. 2007
    ..Inadequate beta-cell function and microalbuminuria are plausible components of the metabolic syndrome in Taiwanese subjects...
  57. ncbi Appropriate waist circumference cutoff values for persons with multiple cardiovascular risk factors in Japan: a large cross-sectional study
    Sachiko Narisawa
    Department of Nursing, School of Health Sciences, Niigata University, Japan
    J Epidemiol 18:37-42. 2008
    ..In this study we aimed to analyze the health-check examination data from a large Japanese population and propose a revised waist circumference cutoff value...
  58. doi Re: Maternal waist circumference and the prediction of children's metabolic syndrome
    Mehmet Emre Atabek
    Arch Pediatr Adolesc Med 162:697; author reply 697-8. 2008
  59. ncbi Anthropometric, metabolic, and dietary fatty acids characteristics in lean and obese dyslipidemic Asian Indian women in Calcutta
    Arnab Ghosh
    Department of Anthropology, Palli Charcha Kendra, Visva Bharati University, Sriniketan, West Bengal, India
    Food Nutr Bull 28:399-405. 2007
    ..There is evidence that women in this population may have comparatively greater risk factors (e.g., dyslipidemia) for CHD than men...
  60. ncbi Metabolic syndrome and its association with diet and physical activity in US adolescents
    Yang Pan
    Department of Nutrition and Food Science, University of Maryland, College Park, MD, USA
    J Am Diet Assoc 108:276-86; discussion 286. 2008
    ..Research on the metabolic syndrome and its association with lifestyle behaviors in adolescents is important for identifying subgroups of youth at whom interventions should be targeted...
  61. pmc Relationships of low serum vitamin D3 with anthropometry and markers of the metabolic syndrome and diabetes in overweight and obesity
    Anne Thea McGill
    University of Auckland Human Nutrition Unit, University of Auckland, Auckland, New Zealand
    Nutr J 7:4. 2008
    ..In the current study, serum vitamin D3 was inversely related to weight, BMI and markers of TIIDM (large waist, raised HbA1c) but not to adipose mass nor to MetSyn per se...
  62. ncbi Associations among sex hormone binding globulin concentrations and characteristics of the metabolic syndrome in obese women
    A S Cikim
    Division of Endocrinology, Metabolism and Nutrition, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
    Diabetes Nutr Metab 17:290-5. 2004
    ..1414, F=10.5627, p<0.001). It is concluded that low SHBG concentrations may indicate a severe degree of insulin resistance in premenopausal obese women...
  63. ncbi Body fat distribution, body composition, and respiratory function in elderly men
    S Goya Wannamethee
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, United Kingdom
    Am J Clin Nutr 82:996-1003. 2005
    ..Most population studies have reported weak or nonsignificant associations between body mass index (BMI; in kg/m2) and lung function...
  64. ncbi Venous thromboembolism--a manifestation of the metabolic syndrome
    Cihan Ay
    Division of Haematology and Haemostaseology, Department of Internal Medicine I, Medical University Vienna, Vienna, Austria
    Haematologica 92:374-80. 2007
    ..Despite its high prevalence, data on the association with venous thromboembolism (VTE) are scarce. The aim of our study was to elucidate the association of the metabolic syndrome with the risk of VTE...
  65. ncbi The predictive value of CRP levels on future severe renal disease in overweight and obese subjects without diabetes mellitus and hypertension
    Erim Gulcan
    Hospital of Dumlupinar University, Department of Internal Medicine, Kutahya, Turkey
    Am J Med Sci 334:444-51. 2007
    ..The aim of this study was to evaluate the predictive value of CRP levels on future severe renal disease...
  66. ncbi Effectiveness of weight loss in the elderly with type 2 diabetes mellitus
    C J Hsieh
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital, Niao Sung Hsiang, Kaohsiung Hsien, Taiwan
    J Endocrinol Invest 28:973-7. 2005
    ..Benefits were gained mainly through reduced body fat. Simple life-style modification of adding 20-min daily aerobic exercise and an adequate but restricted calorie diet is more effective in elderly diabetic patients...
  67. ncbi Obesity increases metabolic syndrome risk factors in school-aged children from an urban school in Mexico city
    Otilia Perichart-Perera
    Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes, Mexico City, Mexico
    J Am Diet Assoc 107:81-91. 2007
    ..To characterize the nutritional status of school-aged children from an urban public school in Mexico City, Mexico, and to assess the influence of obesity on health status in a subgroup of these children...
  68. ncbi Increased abdominal obesity, adverse psychosocial factors and shorter telomere length in subjects reporting early ageing; the MONICA Northern Sweden Study
    K Nordfjäll
    Department of Medical Biosciences, Pathology, Umea University, Umea, Sweden
    Scand J Public Health 36:744-52. 2008
    ..Self-perceived early ageing (SEA) might be a useful indicator of early biological ageing and increased mortality risk. The aim of this population-based study was to identify markers of SEA, including telomere length...
  69. ncbi Waist circumference and body mass index in Chinese children: cutoff values for predicting cardiovascular risk factors
    R Y T Sung
    Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong, China
    Int J Obes (Lond) 31:550-8. 2007
    ..WC provides a measure of central obesity, which has been specifically associated with CV risk factors. Reference standards for WC, and for WC and BMI risk threshold values are not established in Chinese children...
  70. ncbi Plasma interleukin-6 levels, glutathione peroxidase and isoprostane in obese women before and after weight loss. Association with cardiovascular risk factors
    Maria Bougoulia
    Biochemistry Department, Aristotele University Medical School, Thessaloniki, Greece
    Hormones (Athens) 5:192-9. 2006
    ..To evaluate the levels of Interleukin-6 (IL-6), glutathione peroxidase and isoprostane in obese women and their association with markers of cardiovascular risk factors before and after weight loss...
  71. ncbi Metabolic syndrome in nondiabetic, obese, first-degree relatives of African American patients with type 2 diabetes: African American triglycerides-HDL-C and insulin resistance paradox
    Sophia Boudoulas Meis
    Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, The Ohio State University College of Medicine and Public Health, Columbus, Ohio, USA
    Ethn Dis 16:830-6. 2006
    ..Therefore, we investigated the prevalence of components of MetS in obese, glucose-tolerant, first degree relatives of African American patients with type 2 diabetes...
  72. ncbi Relationship between adipokines, inflammation, and vascular reactivity in lean controls and obese subjects with metabolic syndrome
    Luciana Bahia
    Department of Physiological Sciences, Institute of Biology Roberto Alcantara Gomes, State University of Rio de Janeiro, Rio de Janeiro, Brazil
    Clinics (Sao Paulo) 61:433-40. 2006
    ..We investigated the relationship among adipokines, metabolic factors, inflammatory markers, and vascular reactivity in obese subjects with metabolic syndrome and lean controls...
  73. ncbi Type 2 diabetes and impaired fasting blood glucose in rural Bangladesh: a population-based study
    Akhtar Hussain
    Institute of General Practice and Community Medicine, Department of International Health, University of Oslo, Norway
    Eur J Public Health 17:291-6. 2007
    ..Therefore, it is of particular interest to study the epidemiological transition of the state and to identify the risk factors in order to recognize the extent of the problem...
  74. ncbi Obesity and the metabolic syndrome: the stress on society
    W P T James
    International Obesity TaskForce, London, United Kingdom
    Ann N Y Acad Sci 1083:1-10. 2006
    ..This therefore presents a major challenge in both research and public policy terms...
  75. ncbi Obesity and associated cardiovascular risk factors in Iranian children: a cross-sectional study
    Anahita Hamidi
    Endocrinology and Metabolism Research Center, Doctor Shariati Hospital, Tehran University of Medical Science, Tehran, Iran
    Pediatr Int 48:566-71. 2006
    ..The aim of the present study was to investigate frequency of cardiovascular risk factors and their association with severity of obesity in a sample of Iranian obese children...
  76. ncbi Anthropometric predictors of serum fasting insulin in 9- and 15-year-old children and adolescents
    Inga Thorsdottir
    Unit for Nutrition Research, Landspitali University Hospital and Department of Food Science, University of Iceland, 101 Reykjavik, Iceland
    Nutr Metab Cardiovasc Dis 16:263-71. 2006
    ..The aim was to study the association between anthropometric measurements and fasting insulin concentration in a population-based sample of 9- and 15-year-old children and adolescents...
  77. ncbi Body mass, fat distribution and blood pressure in Southern Italian children: results of the ARCA project
    Gianvincenzo Barba
    Epidemiology and Population Genetics, Institute of Food Sciences, National Research Council, Via Roma 52 A C, 83100 Avellino, Italy
    Nutr Metab Cardiovasc Dis 16:239-48. 2006
    ....
  78. ncbi Prevalence of metabolic syndrome in obese Turkish children and adolescents
    Mehmet Emre Atabek
    Department of Pediatric Endocrinology and Diabetes, Selcuk University, School of Medicine, Konya, Turkey
    Diabetes Res Clin Pract 72:315-21. 2006
    ..The aim of our study was to assess the prevalence of metabolic syndrome and the other metabolic features in obese children...
  79. ncbi Obesity indices and cardiovascular risk factors in Thai adults
    W Aekplakorn
    Community Medicine Center, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    Int J Obes (Lond) 30:1782-90. 2006
    ..To examine the relationship of body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHpR) and waist-to-height ratio (WHtR) with cardiovascular risk factors and diabetes in Thai population...
  80. ncbi The obese without cardiometabolic risk factor clustering and the normal weight with cardiometabolic risk factor clustering: prevalence and correlates of 2 phenotypes among the US population (NHANES 1999-2004)
    Rachel P Wildman
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Ave, Belfer Building, Room 1309, Bronx, NY 10461, USA
    Arch Intern Med 168:1617-24. 2008
    ....
  81. ncbi Anthropometric determinants of a clustering of lipid-related metabolic risk factors in overweight and non-overweight adolescents--influence of cardiorespiratory fitness. The Avena study
    Jose L Mesa
    Department of Medical Physiology, School of Medicine, University of Granada, Granada, Spain
    Ann Nutr Metab 50:519-27. 2006
    ....
  82. ncbi Waist circumference and BMI cut-off based on 10-year cardiovascular risk: evidence for "central pre-obesity"
    Gary T C Ko
    Department of Medicine, Alice Ho Miu Ling Nethersole Hospital, 11, Chuen On Road, Tai Po, Hong Kong, China
    Obesity (Silver Spring) 15:2832-9. 2007
    ....
  83. ncbi Analysis of criteria for metabolic syndrome in a population-based study of Japanese-Brazilians
    P Rosenbaum
    Endocrinology Division, Internal Medicine Department, Federal University of Sao Paulo, Sao Paulo, SP, Brazil
    Diabetes Obes Metab 7:352-9. 2005
    ....
  84. ncbi Prevalence and determinants of prehypertension status in the Taiwanese general population
    Pei Shan Tsai
    Taipei Medical University, Taiwan
    J Hypertens 23:1355-60. 2005
    ....
  85. ncbi Effect of body mass index on insulin resistance and lipids in prepubertal and postpubertal children: SCHOOL observations
    David K Murdock
    Cardiovascular Associates of Northern Wisconsin, SC, Wausau, WI, USA
    J Cardiometab Syndr 1:242-7. 2006
    ..Relative insulin resistance prevalence is high among overweight children and adolescents. Biomarkers of increased risk of adverse cardiovascular outcomes are already present in overweight school children...
  86. ncbi Short stature, abdominal obesity, insulin resistance and alterations in lipid profile in very low-income women living in Maceió, north-eastern Brazil
    Telma T Florêncio
    Department of Nutrition, Federal University of Alagoas, Maceio, AL, Brazil
    Eur J Cardiovasc Prev Rehabil 14:346-8. 2007
    ..To test the hypothesis that short stature is associated with abdominal obesity, insulin resistance and lipid profile changes...
  87. ncbi Is there an independent association between waist-to-hip ratio and cardiovascular risk factors in overweight and obese women?
    Fereidoun Azizi
    Endocrine Research Center, Shaheed Beheshti University of Medical Sciences, P O Box 19395 4763, Tehran, I R, Iran
    Int J Cardiol 101:39-46. 2005
    ....
  88. ncbi [Significance of biomarkers for metabolic syndrome during weight reduction]
    H Rochlitz
    Deutsches Institut für Ernährungsforschung Potsdam, Nuthetal und Abteilung für Endokrinologie, Diabetes und Ernährungsmedizin, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Deutschland
    Dtsch Med Wochenschr 130:1061-6. 2005
    ..We aimed to analyse the changes of parameters of the metabolic syndrome and to investigate which markers are useful in the prediction of a successful weight loss. Preliminary data of an ongoing study are presented...
  89. ncbi Correlation of dyslipidemia with waist to height ratio, waist circumference, and body mass index in Iranian adults
    Ali Chehrei
    Department of Pathology, Alzahra University Hospital, Soffeh Street, Isfahan, Iran
    Asia Pac J Clin Nutr 16:248-53. 2007
    ..It can be concluded that W/Ht and WC can best predict dyslipidemia in an Iranian adult population. We suggest using both W/Ht and WC as inexpensive and easy methods in clinical and epidemiological fields...
  90. ncbi Obesity, abdominal obesity, and clustering of cardiovascular risk factors in South Korea
    Hye Soon Park
    Deptartment of Family Medicine, Ulsan University, Seoul, Korea
    Asia Pac J Clin Nutr 12:411-8. 2003
    ....
  91. ncbi Waist circumference and cardiometabolic risk: a consensus statement from Shaping America's Health: Association for Weight Management and Obesity Prevention; NAASO, The Obesity Society; the American Society for Nutrition; and the American Diabetes Associat
    Samuel Klein
    Center for Human Nutrition and the Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Clin Nutr 85:1197-202. 2007
  92. ncbi Strong association between gallstones and cardiovascular disease
    Nahum Mendez-Sanchez
    Department of Biomedical Research, Liver Unit Medica Sur Clinic and Foundation, Mexico City, Mexico
    Am J Gastroenterol 100:827-30. 2005
    ..We have investigated the association between GD and CHD in a cross-sectional study...
  93. ncbi Obesity in the elderly and its relationship with cardiovascular risk factors in Taiwan
    Kuo Chin Huang
    Department of Family Medicine, National Taiwan University Hospital, N141, Institute of Biomedical Sciences, Academia Sinica, 128 Academy Road, Section 2, Taipei, 11529 Taiwan
    Obes Res 13:170-8. 2005
    ..In this study, we examined the prevalence of obesity and relationship between various anthropometric indices (AI) and cardiovascular disease (CVD) risk factors in the elderly...
  94. ncbi Venous thromboembolism in association with features of the metabolic syndrome
    J G Ray
    Department of Medicine, St Michael s Hospital, University of Toronto, Ontario M5B 1W8, Canada
    QJM 100:679-84. 2007
    ..However, whether each of these factors additively increases the risk of VTE is uncertain...
  95. ncbi Moxonidine in the treatment of overweight and obese patients with the metabolic syndrome: a postmarketing surveillance study
    A M Sharma
    McMaster University, Hamilton, ON, Canada
    J Hum Hypertens 18:669-75. 2004
    ..We conclude that moxonidine effectively reduces blood pressure in patients with metabolic syndrome while simultaneously reducing body weight in obese patients...
  96. ncbi [Waist circumference as a predictor of insulin resistance in young men]
    M José Santi
    Departamento de Medicina, Universidad de Cadiz, Cadiz, Spain
    Med Clin (Barc) 125:46-50. 2005
    ..The objective was to determine the relations of WC to cardiovascular risk factors in a sample of young men and to assess the clinical relevance of WC in identifying insulin resistance...
  97. ncbi Body mass index and waist circumference in midchildhood and adverse cardiovascular disease risk clustering in adolescence
    Sarah P Garnett
    Institute of Endocrinology and Diabetes, The Children s Hospital at Westmead, Westmead, Australia
    Am J Clin Nutr 86:549-55. 2007
    ..Body mass index (BMI) may not indicate the level of central adiposity associated with the clustering of cardiovascular disease (CVD) risk factors. Hence, it has been recommended that waist circumference be used as an alternative measure...
  98. ncbi Maternal waist circumference and the prediction of children's metabolic syndrome
    Valeria Hirschler
    Department of Nutrition, Durand Hospital, Maipu 812, Buenos Aires, 1006, Argentina
    Arch Pediatr Adolesc Med 161:1205-10. 2007
    ..To determine the association between metabolic syndrome (MS) components in 620 children and their mothers...
  99. ncbi Body mass index, waist circumference and waist-to-hip ratio cut-off points for categorisation of obesity among Omani Arabs
    Jawad A Al-Lawati
    Department of Non communicable Diseases Surveillance and Control, Muscat 113, Ministry of Health, Oman
    Public Health Nutr 11:102-8. 2008
    ..There are no data on optimal cut-off points to classify obesity among Omani Arabs. The existing cut-off points were obtained from studies of European populations...
  100. ncbi Sleep disturbances in midlife unrelated to 32-year diabetes incidence: the prospective population study of women in Gothenburg
    Cecilia Bjorkelund
    Department of Primary Health Care, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Diabetes Care 28:2739-44. 2005
    ..To study the relation between diabetes incidence and sleep problems in a population-based sample of women followed for 32 years...
  101. ncbi Application of three-dimensional body scanner: observation of prevalence of metabolic syndrome
    J D Lin
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital, Kweishan, Taoyuan Hsien, Taiwan, ROC
    Clin Nutr 23:1313-23. 2004
    ..This retrospective cross-sectional study correlates blood pressure, blood glucose, lipid and uric acid levels with anthropometric measurements...

Research Grants62

  1. Pharmacogenetics of obesity and endocannabinergic modulation (POEM)
    Russell A Wilke; Fiscal Year: 2012
    ..In the future, individual patients with variation in these genes may benefit from targeted behavioral and/or pharmacological interventions designed to improve their health. ..
  2. Daily Experience in Adolescence and Biomarkers of Early Risk for Adult Health
    Andrew J Fuligni; Fiscal Year: 2013
    ..An understanding of these processes is necessary for the development of ethnically and culturally relevant prevention efforts. ..
  3. Research and Mentoring on Energetic Factors and Cancer: Established Investigator
    Leslie Bernstein; Fiscal Year: 2013
    ....
  4. Intestinal Microbiota, Diet and Risk of Colorectal Adenomas
    Robert S Sandler; Fiscal Year: 2013
    ..The findings from this study could help identify individuals at high risk of adenomas as well as enhance the development of strategies to manipulate the intestinal microbiota to prevent colorectal adenomas and cancer ..
  5. Developmental Genes and the Origin of Fat
    C Ronald Kahn; Fiscal Year: 2013
    ....
  6. Biomarkers of Obesity, Prostate Tissue Inflammation, and BPH Progression
    Jay H Fowke; Fiscal Year: 2013
    ..Results may argue for one of several plausible interventions targeting obesity, inflammation, or oxidative stress to delay BPH progression. ..
  7. Genetic Architecture of Adiposity in Multiple Large Cohorts
    Kari E North; Fiscal Year: 2013
    ..This work will stimulate the discovery of variants and pathways, and potentially extend our understanding of the genetic basis of obesity risk and suggest potential therapeutic targets. ..
  8. Health Promotion for Positives: A Randomized Trial with HIV Positive Black Men
    JOHN BARTON JEMMOTT; Fiscal Year: 2013
    ..abstract_text> ..
  9. Assessing the role of androgens in breast cancer risk
    Susan E Hankinson; Fiscal Year: 2013
    ....
  10. Healthy Immigrant Families: Working Together To Move More and To Eat Well
    Mark L Wieland; Fiscal Year: 2013
    ..The use of CBPR will enhance the relevance of this program by targeting socio-cultural determinants of physical activity and nutrition. ..
  11. CORONARY ARTERY DISEASE AND POSTPRANDIAL LIPOPROTEINS
    Henry Ginsberg; Fiscal Year: 1992
    ....
  12. Athletics & Eating Problems in Native & Caucasian Youth
    Wesley Lynch; Fiscal Year: 2003
    ..Ultimately this work should inform decision-making regarding the advisability of specific types of athletic participation as interventions aimed at reducing the risk of eating disorders and/or obesity. ..
  13. RISK OF CHD IN WOMEN WITH POLYCYSTIC OVARY SYNDROME
    Evelyn Talbott; Fiscal Year: 2005
    ..The investigators state that this study has the potential to identify the determinants of early SCA in this high-risk group of women and has important implications for primary as well as secondary prevention. ..
  14. Insulin-like Growth Factors & Esophageal Adenocarcinoma
    Thomas Vaughan; Fiscal Year: 2003
    ..abstract_text> ..
  15. ADIPOSE DISTRIBUTION AND ATHEROSCLEROSIS
    JOHN CROUSE; Fiscal Year: 1992
    ..They further state that establishment of these relationships will provide a rationale for future longitudinal studies...
  16. AGE, EXERCISE, DIET--EFFECTS ON GLUCOSE/FATTY ACID CYCLE
    John Kirwan; Fiscal Year: 1999
    ....
  17. HEALTH OF YOUNG ADULTS--EVIDENCE CAUSES AND OUTCOMES
    DORA COSTA; Fiscal Year: 2000
    ..Few data sources on either recent or past populations provide such a rich array of variables for the study of the impact of health over the life cycle. ..
  18. Glycemic Index and Metabolic Syndrome
    ANASTASSIOS PITTAS; Fiscal Year: 2005
    ..abstract_text> ..
  19. Screening for IGT: Glucose Challenge vs Predictive Model
    Lawrence Phillips; Fiscal Year: 2007
    ..By applying existing knowledge to disease control and prevention, our Specific Aims are the critical first steps to solve this problem. ..
  20. Determinants of C-Reactive Protein
    Ira Ockene; Fiscal Year: 2005
    ..PRIMARY HYPOTHESIS: BMI will be the strongest predictor of hs-CRP. SECONDARY HYPOTHESES: Dietary glycemic load, omega 3 fatty acid intake, and depression will be secondary determinants of hs-CRP. ..
  21. Improving the Accuracy of Pediatric DXA Bone Studies
    Vicente Gilsanz; Fiscal Year: 2009
    ..abstract_text> ..
  22. Early Markers that Presage Obesity in 5-HT2cR KO Mice
    SUSAN AKANA; Fiscal Year: 2004
    ..If the weanling 5-HT2cR KO mouse is obese, 2. If the preweanling 5-HT2cR KO 10 day old pup is behaviorally hyperphagic, and 3. whether the 5-HT2cR KO mouse has a lower metabolic rate. ..
  23. EPIDEMIOLOGY OF OSTEOARTHRITIS AND DISC DEGENERATION
    Maradee Davis; Fiscal Year: 1990
    ....
  24. Genome Scan for Obesity in a Multi-Ethnic Sample
    Xiaofeng Zhu; Fiscal Year: 2002
    ..The enormous data repository created by this project presents an important opportunity to make use of this technique. ..
  25. RACISM, STRESS AND CHRONIC DISEASE IN OLDER BLACKS
    MICHELLE TARVER CARR; Fiscal Year: 2000
    ..abstract_text> ..
  26. Impaired Glucose Metabolism in HIV-Infected Drug Users
    Andrea Howard; Fiscal Year: 2007
    ..She will also complete coursework in the conduct of diabetes-related clinical research, addiction medicine, and the responsible conduct of research. ..
  27. A PRIMARY CARE INTERVENTION FOR OBESITY
    Everett Logue; Fiscal Year: 2001
    ..The TM-CD intervention is unique in its application of the principles of the TM Model of change in combination with the tenets of the chronic disease care paradigm in primary care. ..
  28. Maternal overnutrition and offspring fat mass, metabolic and vascular function.
    Debbie Lawlor; Fiscal Year: 2009
    ....
  29. Gene-Environment Interactions in Obesity and Diabetes
    Tracy Nelson; Fiscal Year: 2007
    ..Environment: Dr. Nelson will have an outstanding environment in which to carry out the proposed study, as well as, the necessary resources and support to successfully complete her training. ..
  30. SWAN Sleep Study II - Michigan Center
    MaryFran Sowers; Fiscal Year: 2008
    ..The results can inform primary prevention of adverse health outcomes due to the menopause-related sleep disturbances. [unreadable] [unreadable] [unreadable]..
  31. Change in Bone, Arthritis, Function: Hormones & Obesity
    MaryFran Sowers; Fiscal Year: 2009
    ....
  32. Zonisamide for Weight Reduction in Obese Adults
    Kishore Gadde; Fiscal Year: 2009
    ..We will also systematically assess whether weight loss achieved with zonisamide treatment can reduce metabolic and cardiovascular risk factors. ..
  33. MODELS FOR THE GENETIC EPIDEMIOLOGY OF CHRONIC DISEASE
    SANDRA HASSTEDT; Fiscal Year: 2009
    ..In addition, this application proposes to implement changes to increase computational speed, allow data exploration, and facilitate data handling and analysis, while continuing to distribute and support PAP. ..
  34. Functional Status and the Menopause Transition
    MaryFran R Sowers; Fiscal Year: 2010
    ..Among the elderly, older women live longer, develop more chronic disease and experience more prolonged and severe disability than older men. ..
  35. FOUR-CORNERS BREAST AND ENDOMETRIAL CANCER STUDY
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2003
    ..C-peptide, glycosylated hemoglobin, IGF-1, and IGFBP3 will be evaluated with respect to breast and endometrial cancer in a subset of women. ..
  36. CHRONIC OBSTRUCTIVE PULMONARY DISEASE GENE LOCALIZATION
    SANDRA HASSTEDT; Fiscal Year: 2002
    ..Identifying a gene that when mutated increases the risk of COPD may increase understanding of pulmonary function, as well as allowing gene-carriers to be identified and made aware of their susceptibility. ..
  37. PROSPECTIVE STUDY OF HEALTH IN RUNNERS AND WALKERS
    Paul Williams; Fiscal Year: 2002
    ..1%). Additionally, a detectable reduction in breast cancer risk as small as 1.5% per mile run in women is calculated, which is below the 1.7% reduction in risk estimated from other published data. ..
  38. A Risk Score for Cardiovascular Disease in Older Adult
    Arun Karlamangla; Fiscal Year: 2008
    ..The proposed research will lead to better risk assessment and to improved targeting of preventive interventions in these older adults. ..
  39. Impact of feeding on brain response to food stimuli in lean and obese subjects
    Marie Pierre St Onge; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  40. A PROSPECTIVE STUDY OF ALASKA NATIVES & AMERICAN INDIANS
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2006
    ..The AIAN cohort will serve as a resource to enhance research and training activities of AIAN students interested in health research, health education, and general public health. ..
  41. Inflammation: Effect on Insulin Resistance in PCOS
    Frank Gonzalez; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  42. Aripiprazole for Clozapine Associated Medical Morbidity
    David Henderson; Fiscal Year: 2007
    ..Clinical adjunctive therapy may establish aripiprazole as a new therapeutic approach in schizophrenia and clozapine-associated medical disorders. ..
  43. Gene-Specific Responses to Exercise in Discordant Twins
    Paul Williams; Fiscal Year: 2007
    ..DNA samples will be shared with other institutions to cross-validate gene associations identified from training studies or other designs. ..
  44. Long-Term Exercise Maintenance via Internet Support
    Paul Williams; Fiscal Year: 2006
    ..We estimate that we will be able to detect differences in exercise cessation rates between the intervention and control group of 0.45% in runners and walkers separately (alpha=0.05, 80% statistical power). ..
  45. Growth Factors and Colon Cancer
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2006
    ..This study builds on a unique existing resource to study genetic and environmental associations with colorectal cancer. It will provide insight into colon cancer etiology and therefore avenues to disease prevention. ..
  46. Estrogen, Metabolism, Menopause, and Health Outcomes
    MaryFran Sowers; Fiscal Year: 2006
    ..This is a unique opportunity to prospectively integrate lifestyle elements with measures of hormone metabolism pathways into a comprehensive examination of multiple human health effects. ..
  47. DIET AND SOMATIC MUTATIONS IN COLON CANCER
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2007
    ..e. p53, K-ras, and microsatellite instability). Differences in colon and rectal tumors will be compared. Additionally data from rectal tumors will be combined with that from colon tumors to define disease pathways. ..
  48. Benefits & Risks of Popular Weight Loss Diets
    Christopher Gardner; Fiscal Year: 2003
    ..The data generated from this preliminary/feasibility study will be used to strengthen the proposal and design of a future full-scale study. ..
  49. SLEEP AS A MEDIATOR OF THE STRESS/HEALTH RELATIONSHIP
    Martica Hall; Fiscal Year: 2002
    ....
  50. ALA & EPA/DHA (w-3) Effects On Inflammatory Markers in Insulin Resistant Adults
    Christopher Gardner; Fiscal Year: 2007
    ..The adults with the metabolic syndrome selected for this study are those that are at increased risk of heart disease, and those most likely to be benefit from the different therapies tested. [unreadable] [unreadable] [unreadable]..
  51. EXERCISE TRAINING IN OLDER HYPERTENSIVE MEN AND WOMEN
    Kerry Stewart; Fiscal Year: 2002
    ..The results from this study will expand the scientific knowledge that defines exercise guidelines for older men and women at risk for CVD because of their BP levels. ..
  52. CORTICAL SURFACE BASED BRAIN IMAGING
    Anders Dale; Fiscal Year: 2002
    ..The software tools will be ported to several platforms, including SGI, Sun and PC (Linux), in order to facilitate their dissemination to the wider scientific community. ..
  53. HER2/neu and dietary fat: interactions in breast cancer
    Lisa Yee; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  54. CONTROL OF ENDOCANNABINOID RELEASE IN VIVO
    Daniele Piomelli; Fiscal Year: 2003
    ..Moreover, by uncovering the neurochemical interactions between cocaine and the endogenous cannabinoids, our studies will contribute to the general understanding of substance abuse and neuropsychiatric disorders. ..
  55. Determinants of Bone Strength in Afro-Caribbean Families
    Joseph Zmuda; Fiscal Year: 2004
    ..The identification of these genes will likely yield fundamental insight on bone biology and may lead to the development of novel approaches to the diagnosis, treatment, and prevention of osteoporosis. ..
  56. Characterization of a novel brain cannabinoid ligand
    Daniele Piomelli; Fiscal Year: 2010
    ..The objective of our research is to understand how these transmitters are produced and eliminated, and discover innovative medicines that target these processes. ..
  57. Molecular Epidemiology of non-Hodgkin Lymphoma Survival
    James R Cerhan; Fiscal Year: 2010
    ..Host genetics may also lead to a better understanding of NHL pathophysiology that could lead to new approaches to improve the survival of NHL patients. ..
  58. GENETICS OF ADIPOSITY AND GLUCOSE HOMEOSTASIS
    Jill Norris; Fiscal Year: 2009
    ....
  59. Role of Endocannabinoids in the Behavioral Consequences of Social Isolation
    Daniele Piomelli; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  60. Outcomes and Care Practices in Lower Intestinal Bleeding
    Lisa Strate; Fiscal Year: 2008
    ..These studies will also provide the skills and data that are critical for planning future investigations. ..
  61. TRIAL OF ACTIVITY FOR ADOLESCENT GIRLS (TAAG)
    June Stevens; Fiscal Year: 2006
    ..abstract_text> ..