organ size

Summary

Summary: The measurement of an organ in volume, mass, or heaviness.

Top Publications

  1. ncbi YAP1 increases organ size and expands undifferentiated progenitor cells
    Fernando D Camargo
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Curr Biol 17:2054-60. 2007
  2. pmc The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal
    Bin Zhao
    Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang 310058, China
    Nat Cell Biol 13:877-83. 2011
  3. ncbi Regional brain changes in aging healthy adults: general trends, individual differences and modifiers
    Naftali Raz
    Department of Psychology and Institute of Gerontology, Wayne State University, 87 East Ferry St, 226 Knapp Building, Detroit, MI 48202, USA
    Cereb Cortex 15:1676-89. 2005
  4. ncbi Limbic scars: long-term consequences of childhood maltreatment revealed by functional and structural magnetic resonance imaging
    Udo Dannlowski
    Department of Psychiatry, University of Munster, Albert Schweitzer Strasse 11, Munster, Germany
    Biol Psychiatry 71:286-93. 2012
  5. ncbi Control of osteoblast function and regulation of bone mass
    Shun ichi Harada
    Department of Bone Biology and Osteoporosis Research, Merck Research Laboratories, West Point, Pennsylvania 19002, USA
    Nature 423:349-55. 2003
  6. pmc The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control
    Lei Zhang
    Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Dev Cell 14:377-87. 2008
  7. ncbi Evolution in the social brain
    R I M Dunbar
    British Academy Centenary Research Project, School of Biological Sciences, University of Liverpool, Liverpool L69 7ZB, UK
    Science 317:1344-7. 2007
  8. ncbi Nephron number in patients with primary hypertension
    Gunhild Keller
    Department of Pathology, University of Heidelberg, Heidelberg, Germany
    N Engl J Med 348:101-8. 2003
  9. ncbi The emerging role of the hippo pathway in cell contact inhibition, organ size control, and cancer development in mammals
    Qi Zeng
    Cancer and Developmental Cell Biology Division, Institute of Molecular and Cell Biology, A STAR Agency for Science, Technology and Research, 61 Biopolis Drive, Singapore 138673, Singapore
    Cancer Cell 13:188-92. 2008
  10. pmc Age-related differences in regional brain volumes: a comparison of optimized voxel-based morphometry to manual volumetry
    Kristen M Kennedy
    Institute of Gerontology, Department of Psychology, Wayne State University, Detroit, MI, USA
    Neurobiol Aging 30:1657-76. 2009

Detail Information

Publications390 found, 100 shown here

  1. ncbi YAP1 increases organ size and expands undifferentiated progenitor cells
    Fernando D Camargo
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Curr Biol 17:2054-60. 2007
    The mechanisms that regulate mammalian organ size are poorly understood. It is unclear whether the pathways that control organ size also impinge on stem/progenitor cells...
  2. pmc The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal
    Bin Zhao
    Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang 310058, China
    Nat Cell Biol 13:877-83. 2011
    Precise control of organ size is crucial during animal development and regeneration...
  3. ncbi Regional brain changes in aging healthy adults: general trends, individual differences and modifiers
    Naftali Raz
    Department of Psychology and Institute of Gerontology, Wayne State University, 87 East Ferry St, 226 Knapp Building, Detroit, MI 48202, USA
    Cereb Cortex 15:1676-89. 2005
    ..No sex differences in age trends except for the caudate were observed. We found no evidence of neuroprotective effects of larger brain size or educational attainment...
  4. ncbi Limbic scars: long-term consequences of childhood maltreatment revealed by functional and structural magnetic resonance imaging
    Udo Dannlowski
    Department of Psychiatry, University of Munster, Albert Schweitzer Strasse 11, Munster, Germany
    Biol Psychiatry 71:286-93. 2012
    ....
  5. ncbi Control of osteoblast function and regulation of bone mass
    Shun ichi Harada
    Department of Bone Biology and Osteoporosis Research, Merck Research Laboratories, West Point, Pennsylvania 19002, USA
    Nature 423:349-55. 2003
    ..Recent advances, spearheaded by genetic information, offer the opportunity to stop or reverse this downhill course...
  6. pmc The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control
    Lei Zhang
    Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Dev Cell 14:377-87. 2008
    ..Inactivation of Sd diminishes Hpo target gene expression and reduces organ size, whereas a constitutively active Sd promotes tissue overgrowth...
  7. ncbi Evolution in the social brain
    R I M Dunbar
    British Academy Centenary Research Project, School of Biological Sciences, University of Liverpool, Liverpool L69 7ZB, UK
    Science 317:1344-7. 2007
    ..This may explain why primate sociality seems to be so different from that found in most other birds and mammals: Primate sociality is based on bonded relationships of a kind that are found only in pairbonds in other taxa...
  8. ncbi Nephron number in patients with primary hypertension
    Gunhild Keller
    Department of Pathology, University of Heidelberg, Heidelberg, Germany
    N Engl J Med 348:101-8. 2003
    ..A diminished number of nephrons has been proposed as one of the factors contributing to the development of primary hypertension...
  9. ncbi The emerging role of the hippo pathway in cell contact inhibition, organ size control, and cancer development in mammals
    Qi Zeng
    Cancer and Developmental Cell Biology Division, Institute of Molecular and Cell Biology, A STAR Agency for Science, Technology and Research, 61 Biopolis Drive, Singapore 138673, Singapore
    Cancer Cell 13:188-92. 2008
    ..publications establish that the pathway is one major conserved mechanism governing cell contact inhibition, organ size control, and cancer development...
  10. pmc Age-related differences in regional brain volumes: a comparison of optimized voxel-based morphometry to manual volumetry
    Kristen M Kennedy
    Institute of Gerontology, Department of Psychology, Wayne State University, Detroit, MI, USA
    Neurobiol Aging 30:1657-76. 2009
    ..It may be beneficial to use VBM as a first-pass strategy, followed by manual measurement of anatomically defined regions...
  11. ncbi The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology
    Lukas Pezawas
    Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1379, USA
    J Neurosci 24:10099-102. 2004
    ....
  12. pmc The Hippo-YAP pathway: new connections between regulation of organ size and cancer
    Bin Zhao
    Department of Pharmacology and Moores Cancer Center, University of California at San Diego, La Jolla, CA 92093 0815, USA
    Curr Opin Cell Biol 20:638-46. 2008
    The control of organ size is a basic biological question. In the past several years, the Hippo signaling pathway has been delineated and shown to be crucial in control of organ size in both Drosophila and mammals...
  13. ncbi Left atrial size: physiologic determinants and clinical applications
    Walter P Abhayaratna
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 47:2357-63. 2006
    ..More data are required with respect to the natural history of LA remodeling in disease, the degree of LA modifiability with therapy, and whether regression of LA size translates into improved cardiovascular outcomes...
  14. pmc Investigation of mindfulness meditation practitioners with voxel-based morphometry
    Britta K Hölzel
    Bender Institute of Neuroimaging, Justus Liebig University, 35394 Giessen, Germany
    Soc Cogn Affect Neurosci 3:55-61. 2008
    ..Results suggest that meditation practice is associated with structural differences in regions that are typically activated during meditation and in regions that are relevant for the task of meditation...
  15. ncbi Reduced medial prefrontal cortex volume in adults reporting childhood emotional maltreatment
    Anne Laura van Harmelen
    Leiden Institute for Brain and Cognition, The Netherlands
    Biol Psychiatry 68:832-8. 2010
    ..However, in humans, the neurobiological correlates of CEM are unknown...
  16. pmc The conserved phosphoinositide 3-kinase pathway determines heart size in mice
    T Shioi
    Cardiovascular Division, Beth Israel Deaconess Medical Center and Departments of Medicine and Cell Biology, Harvard Medical School, Boston, MA 02215, USA
    EMBO J 19:2537-48. 2000
    Phosphoinositide 3-kinase (PI3K) has been shown to regulate cell and organ size in Drosophila, but the role of PI3K in vertebrates in vivo is not well understood...
  17. ncbi The Parieto-Frontal Integration Theory (P-FIT) of intelligence: converging neuroimaging evidence
    Rex E Jung
    Departments of Neurology and Psychology, University of New Mexico, Albuquerque, NM 87106, USA
    Behav Brain Sci 30:135-54; discussion 154-87. 2007
    ..Moreover, the model provides a framework for testing new hypotheses in future experimental designs...
  18. ncbi When is the brain enlarged in autism? A meta-analysis of all brain size reports
    Elizabeth Redcay
    Department of Psychology, University of California, San Diego, USA
    Biol Psychiatry 58:1-9. 2005
    ..These conflicting results may be due to a lack of accounting for age-related changes in brain enlargement, use of small sample sizes, or differences in data acquisition methods...
  19. pmc Organ size control by Hippo and TOR pathways
    Karen Tumaneng
    Department of Pharmacology and Sanford Consortium for Regenerative Medicine, University of California at San Diego, La Jolla, CA 92093, USA
    Curr Biol 22:R368-79. 2012
    The determination of final organ size is a highly coordinated and complex process that relies on the precise regulation of cell number and/or cell size...
  20. pmc Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression
    Hai Song
    Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:1431-6. 2010
    Control of organ size by cell proliferation and survival is a fundamental developmental process, and its deregulation leads to cancer. However, the molecular mechanism underlying organ size control remains elusive in vertebrates...
  21. pmc Brain-derived neurotrophic factor is associated with age-related decline in hippocampal volume
    Kirk I Erickson
    Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 30:5368-75. 2010
    ..Caudate nucleus volume was unrelated to BDNF levels or spatial memory performance. Our results identify serum BDNF as a significant factor related to hippocampal shrinkage and memory decline in late adulthood...
  22. pmc Role for Akt3/protein kinase Bgamma in attainment of normal brain size
    Rachael M Easton
    Department of Medicine, University of Pennsylvania School of Medicine, Clinical Research Building 322, 415 Curie Blvd, Philadelphia, PA 19104, USA
    Mol Cell Biol 25:1869-78. 2005
    ..not required for the maintenance of normal carbohydrate metabolism but is essential for the attainment of normal organ size. However, in contrast to Akt1-/- mice, which display a proportional decrease in the sizes of all organs, Akt3-/- ..
  23. pmc Bioelectric signaling regulates head and organ size during planarian regeneration
    Wendy Scott Beane
    Biology Department and Tufts Center for Regenerative and Developmental Biology, Tufts University, 200 Boston Avenue, Suite 4600, Medford, MA 02155, USA
    Development 140:313-22. 2013
    ..Our data show that this disproportionality results from a lack of the apoptosis required to adjust head and organ size and placement, highlighting apoptotic remodeling as the link between bioelectric signaling and the establishment ..
  24. ncbi Relationship between body mass index and gray matter volume in 1,428 healthy individuals
    Yasuyuki Taki
    Department of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer IDAC, Tohoku University, Sendai, Japan
    Obesity (Silver Spring) 16:119-24. 2008
    ....
  25. pmc Brain structure and obesity
    Cyrus A Raji
    Department of Pathology, University of Pittsburgh, Pennsylvania, USA
    Hum Brain Mapp 31:353-64. 2010
    ..Higher BMI was associated with lower brain volumes in overweight and obese elderly subjects. Obesity is therefore associated with detectable brain volume deficits in cognitively normal elderly subjects...
  26. ncbi Subchronic inhalation toxicity of silver nanoparticles
    Jae Hyuck Sung
    Korea Environment and Merchandise Testing Institute, Incheon, Korea
    Toxicol Sci 108:452-61. 2009
    ..Target organs for silver nanoparticles were considered to be the lungs and liver in the male and female rats. No observable adverse effect level of 100 microg/m(3) is suggested from the experiments...
  27. ncbi A new player in the orchestra of cell growth: SREBP activity is regulated by mTORC1 and contributes to the regulation of cell and organ size
    Thomas Porstmann
    Gene Expression Analysis Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Biochem Soc Trans 37:278-83. 2009
    ..regulation of lipogenesis genes by the SREBP (sterol-regulatory-element-binding protein) transcription factor, a central regulator of expression of lipogenic genes, to the control of cell size in vitro and cell and organ size in vivo.
  28. ncbi Automatic differentiation of anatomical patterns in the human brain: validation with studies of degenerative dementias
    Catriona D Good
    Wellcome Department of Cognitive Neurology, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, United Kingdom
    Neuroimage 17:29-46. 2002
    ....
  29. ncbi Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation
    Markus Schubert
    Howard Hughes Medical Institute, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Neurosci 23:7084-92. 2003
    ..Thus, dysregulation of the Irs2 branch of the insulin-Igf-signaling cascade reveals a molecular link between diabetes and neurodegenerative disease...
  30. ncbi Validity of fan-beam dual-energy X-ray absorptiometry for measuring fat-free mass and leg muscle mass. Health, Aging, and Body Composition Study--Dual-Energy X-ray Absorptiometry and Body Composition Working Group
    M Visser
    Epidemiology, Demography and Biometry Program, National Institute on Aging, Bethesda, Maryland 20892, USA
    J Appl Physiol (1985) 87:1513-20. 1999
    ..86-0.96). MM by DEXA was higher than by CT in three regions. The results of this study suggest that fan-beam DEXA offers considerable promise for the measurement of total body FFM and leg MM in elderly persons...
  31. pmc Stability of inbred mouse strain differences in behavior and brain size between laboratories and across decades
    Douglas Wahlsten
    Department of Psychology, University of Alberta, Edmonton, AB, Canada T6G 2E9
    Proc Natl Acad Sci U S A 103:16364-9. 2006
    ..Phenotypic drift over decades for most of the behaviors examined appears to be minimal...
  32. pmc Longitudinal pattern of regional brain volume change differentiates normal aging from MCI
    I Driscoll
    Laboratory of Personality and Cognition, National Institute on Aging, Baltimore, MD 21224, USA
    Neurology 72:1906-13. 2009
    ..We predict that the regions that show early pathologic changes in association with Alzheimer disease will show accelerated volume loss in mild cognitive impairment (MCI) compared to normal aging...
  33. ncbi Control of final organ size by Mediator complex subunit 25 in Arabidopsis thaliana
    Ran Xu
    State Key Laboratory of Plant Cell and Chromosome Engineering, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    Development 138:4545-54. 2011
    Control of organ size by cell proliferation and cell expansion is a fundamental developmental process, but the mechanisms that establish the final size of organs and whole organisms remain elusive in plants and animals...
  34. ncbi Changes in the developmental trajectories of striatum in autism
    Marieke Langen
    Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Biol Psychiatry 66:327-33. 2009
    ..The objective was to examine brain development in a homogeneous sample of subjects with high-functioning autism...
  35. ncbi Regulation of organ size: insights from the Drosophila Hippo signaling pathway
    Madhuri Kango-Singh
    Division of Basic Sciences, Mercer University School of Medicine, Macon, Georgia 31207, USA
    Dev Dyn 238:1627-37. 2009
    b>Organ size control is a fundamental and core process of development of all multicellular organisms. One important facet of organ size control is the regulation of cell proliferation and cell death...
  36. ncbi Efficacy of serotonin inhibition in mouse models of bone loss
    Hiroyuki Inose
    Departments of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA
    J Bone Miner Res 26:2002-11. 2011
    ..This study provides a more comprehensive view of the anabolic efficacy of Tph1 inhibitors and further establishes the spectrum of their therapeutic potential in the treatment of bone-loss disorders...
  37. ncbi Cadmium mimics the in vivo effects of estrogen in the uterus and mammary gland
    Michael D Johnson
    Department of Oncology, Lombardi Cancer Center, Georgetown University, Washington, DC 20007, USA
    Nat Med 9:1081-4. 2003
    ..In utero exposure to the metal also mimicked the effects of estrogens. Female offspring experienced an earlier onset of puberty and an increase in the epithelial area and the number of terminal end buds in the mammary gland...
  38. ncbi Structural brain differences and cognitive functioning related to body mass index in older females
    Katrin Walther
    Department of Psychology, University of Arizona, Tucson, Arizona 85721 0068, USA
    Hum Brain Mapp 31:1052-64. 2010
    ..The results provide additional evidence for a negative link between increased body fat and brain functioning in older females...
  39. ncbi Phytoestrogens and carcinogenesis-differential effects of genistein in experimental models of normal and malignant rat endometrium
    P Diel
    , Deutsche Sporthochschule, , Germany
    Hum Reprod 16:997-1006. 2001
    ....
  40. pmc A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait
    Randall D Little
    Department of Human Genetics, Genome Therapeutics Corporation, Waltham, MA 02453, USA
    Am J Hum Genet 70:11-9. 2002
    ..Our findings suggest that the HBM mutation confers a unique osteogenic activity in bone remodeling, and this understanding may facilitate the development of novel therapies for the treatment of osteoporosis...
  41. pmc Whole brain size and general mental ability: a review
    J Philippe Rushton
    Departments of Psychology and Biology, University of Western Ontario, London, Ontario, Canada
    Int J Neurosci 119:691-731. 2009
    ..Finally, we examine brain size and mental ability from an evolutionary and behavior genetic perspective...
  42. ncbi Regional brain volume in depression and anxiety disorders
    Marie Jose van Tol
    Department of Psychiatry, Leiden University Medical Center, The Netherlands
    Arch Gen Psychiatry 67:1002-11. 2010
    ..Major depressive disorder (MDD), panic disorder, and social anxiety disorder are among the most prevalent and frequently co-occurring psychiatric disorders in adults and may have, at least in part, a common etiology...
  43. ncbi Contribution of the umbilical cord and membranes to untrimmed placental weight
    S D Leary
    Medical Research Council Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, UK
    Placenta 24:276-8. 2003
    ..However, the mode of delivery had a significant effect on this difference; medians for vaginal and Caesarean section deliveries were 19 per cent and 14 per cent respectively...
  44. ncbi Brain-derived neurotrophic factor val66met polymorphism and volume of the hippocampal formation
    P R Szeszko
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY, USA
    Mol Psychiatry 10:631-6. 2005
    ..These findings implicate genetic involvement of BDNF in variation of human hippocampal volume and suggest that this effect may be greater among patients compared to healthy volunteers...
  45. ncbi Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver
    Ben Z Stanger
    Department of Molecular and Cellular Biology, Harvard Stem Cell Institute, and Howard Hughes Medical Institute, Cambridge, Massachusetts 02138, USA
    Nature 445:886-91. 2007
    The determinants of vertebrate organ size are poorly understood, but the process is thought to depend heavily on growth factors and other environmental cues...
  46. ncbi Do antipsychotic drugs affect brain structure? A systematic and critical review of MRI findings
    S Navari
    Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College London, UK
    Psychol Med 39:1763-77. 2009
    ..This review addresses two issues: (1) do antipsychotic medications induce changes in total or regional human brain volumes and (2) do such effects depend on antipsychotic type?..
  47. pmc Big brains, enhanced cognition, and response of birds to novel environments
    Daniel Sol
    Centre de Recerca Ecològica i Aplicacions Forestals, Universitat Autonoma de Barcelona, E 08193 Bellaterra, Catalonia, Spain
    Proc Natl Acad Sci U S A 102:5460-5. 2005
    ..These findings provide strong evidence for the hypothesis that enlarged brains function, and hence may have evolved, to deal with changes in the environment...
  48. pmc Scaling of human body composition to stature: new insights into body mass index
    Steven B Heymsfield
    From Merck and Company, Rahway, NJ 07065 0900, USA
    Am J Clin Nutr 86:82-91. 2007
    ..Although Quetelet first reported in 1835 that adult weight scales to the square of stature, limited or no information is available on how anatomical body compartments, including adipose tissue (AT), scale to height...
  49. ncbi Control of plant organ size by KLUH/CYP78A5-dependent intercellular signaling
    Elena Anastasiou
    Institut fur Biologie III, Universitat Freiburg, Schanzlestrasse 1, D 79104 Freiburg, Germany
    Dev Cell 13:843-56. 2007
    ..growth factors is thought to be an effective mechanism for measuring primordium size, yet how plants gauge organ size is unclear...
  50. pmc Toxicologic effects of gold nanoparticles in vivo by different administration routes
    Xiao Dong Zhang
    Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, and Tianjin Key Laboratory of Molecular Nuclear Medicine, Tianjin, People s Republic of China
    Int J Nanomedicine 5:771-81. 2010
    ..Combining the results of all of these studies, we suggest that targeted gold nanopartices by tail vein injection may be suitable for enhancement of radiotherapy, photothermal therapy, and related medical diagnostic procedures...
  51. pmc Double muscling in cattle due to mutations in the myostatin gene
    A C McPherron
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 94:12457-61. 1997
    ....
  52. ncbi Induction of spermatogenesis by androgens in gonadotropin-deficient (hpg) mice
    J Singh
    Department of Obstetrics and Gynecology, University of Sydney, New South Wales, Australia
    Endocrinology 136:5311-21. 1995
    ..The hpg mouse model is a useful new paradigm to study the molecular basis of the hormonal induction of spermatogenesis...
  53. pmc Cellular scaling rules for primate brains
    Suzana Herculano-Houzel
    Department of Psychology, Vanderbilt University, Nashville, TN 37203, USA
    Proc Natl Acad Sci U S A 104:3562-7. 2007
    ..As a consequence of the linear cellular scaling rules, primate brains have a larger number of neurons than rodent brains of similar size, presumably endowing them with greater computational power and cognitive abilities...
  54. pmc Effects of prenatal exposure to surface-coated nanosized titanium dioxide (UV-Titan). A study in mice
    Karin S Hougaard
    National Research Centre for the Working Environment, Copenhagen Ø, Denmark
    Part Fibre Toxicol 7:16. 2010
    ..Consequently, also toxicological properties may change compared to the parent compound. We examined developmental and neurobehavioral effects following maternal exposure to a nanoparticulate UV-filter (UV-titan L181)...
  55. pmc The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling
    Martin A Jünger
    Zoologisches Institut, Universitat Zurich, Winterthurerstr, 190, CH 8057 Zurich, Switzerland
    J Biol 2:20. 2003
    ..In this study, we present a genetic characterization of dFOXO, the only Drosophila FOXO ortholog...
  56. ncbi Kolaviron, a natural antioxidant and anti-inflammatory phytochemical prevents dextran sulphate sodium-induced colitis in rats
    Ebenezer O Farombi
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Basic Clin Pharmacol Toxicol 113:49-55. 2013
    ..In conclusion, the anti-colitis effect of kolaviron is related to its intrinsic anti-inflammatory and anti-oxidative properties...
  57. ncbi Correlation among body height, intelligence, and brain gray matter volume in healthy children
    Yasuyuki Taki
    Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980 8575, Japan
    Neuroimage 59:1023-7. 2012
    ....
  58. pmc Allometry indicates giant eyes of giant squid are not exceptional
    Lars Schmitz
    Department of Evolution and Ecology, University of California, Davis, CA 95616, USA
    BMC Evol Biol 13:45. 2013
    ..However, it is poorly understood how the eye size of giant and colossal squid compares to that of other aquatic organisms when scaling effects are considered...
  59. ncbi Morphogens, nutrients, and the basis of organ scaling
    Joseph Parker
    Department of Genetics and Development, Columbia University College of Physicians and Surgeons, 701 West 168th Street, New York, NY 10032, USA
    Evol Dev 13:304-14. 2011
    The regulation of organ size is a long-standing problem in animal development. Studies in this area have shown that organ-intrinsic patterning morphogens influence organ size, guiding growth in accordance with positional information...
  60. pmc In vivo study of spherical gold nanoparticles: inflammatory effects and distribution in mice
    Hui Chen
    School of Medical and Molecular Biosciences, Faculty of Science, University of Technology Sydney, Sydney, New South Wales, Australia
    PLoS ONE 8:e58208. 2013
    ..This project investigated the distribution, organ toxicity and changes in inflammatory cytokines within the adipose tissue after mice were exposed to AuNPs...
  61. pmc Extraversion is linked to volume of the orbitofrontal cortex and amygdala
    Henk Cremers
    Institute for Psychological Research, Clinical, Health and Neuropsychology Unit, Leiden University, Leiden, The Netherlands
    PLoS ONE 6:e28421. 2011
    ....
  62. pmc Maternal cortisol over the course of pregnancy and subsequent child amygdala and hippocampus volumes and affective problems
    Claudia Buss
    Department of Pediatrics, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 109:E1312-9. 2012
    ..The results underscore the importance of the intrauterine environment and suggest the origins of neuropsychiatric disorders may have their foundations early in life...
  63. pmc Fetal growth versus birthweight: the role of placenta versus other determinants
    Marie Cecilie Paasche Roland
    Department of Obstetrics, Oslo University Hospital, Oslo, Norway
    PLoS ONE 7:e39324. 2012
    ..We aimed to study the effects of maternal characteristics on both birthweight and fetal growth in third trimester and introduce placental weight as a possible determinant of both birthweight and fetal growth in third trimester...
  64. pmc Leptin deficiency contributes to the pathogenesis of alcoholic fatty liver disease in mice
    Xiaobing Tan
    Center for Translational Biomedical Research, University of North Carolina at Greensboro, North Carolina Research Campus, Kannapolis, North Carolina 28081, USA
    Am J Pathol 181:1279-86. 2012
    ..These data demonstrated for the first time that leptin deficiency in association with WAT mass reduction contributes to the pathogenesis of alcoholic fatty liver disease...
  65. ncbi Integrating force-sensing and signaling pathways in a model for the regulation of wing imaginal disc size
    Tinri Aegerter-Wilmsen
    Institute of Molecular Life Sciences, University of Zurich, CH 8057, Switzerland
    Development 139:3221-31. 2012
    The regulation of organ size constitutes a major unsolved question in developmental biology. The wing imaginal disc of Drosophila serves as a widely used model system to study this question...
  66. ncbi Preliminary evidence of hippocampal damage in chronic users of ecstasy
    Bjørnar den Hollander
    Graduate School of Neurosciences, Department of Radiology, Academic Medical Center, Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 83:83-5. 2012
    ..032). These data provide preliminary evidence that ecstasy users may be prone to incurring hippocampal damage, in line with previous reports of acute hippocampal sclerosis and subsequent atrophy in chronic users of this drug...
  67. pmc Heritability of brain ventricle volume: converging evidence from inconsistent results
    William S Kremen
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Neurobiol Aging 33:1-8. 2012
    ..These conclusions have implications for the basic understanding of the genetic and environmental underpinnings of normative and pathological brain aging...
  68. ncbi Is hippocampal volume a good marker to differentiate Alzheimer's disease from frontotemporal dementia?
    Leonardo Cruz de Souza
    CRicm, UPMC Univ Paris 06, INSERM, UMR S 678, Paris, France
    J Alzheimers Dis 36:57-66. 2013
    ..However, these studies did not include patients selected according to clinico-biological criteria, using pathophysiological biomarkers...
  69. ncbi Characterization of endocrine-disrupting chemicals based on hormonal balance disruption in male and female adult rats
    Nadia Quignot
    Experimental Toxicology Unit, INERIS, Parc Technologique ALATA, 60550 Verneuil en Halatte, France
    Reprod Toxicol 33:339-52. 2012
    ..In vinclozolin-treated animals, the decreased estrogen-to-androgen ratios reported might be due to an increase of peripheral (adrenal) steroidogenesis. Thus, measurement of many endpoints is necessary for good risk assessment...
  70. pmc Automated segmentation of hippocampal subfields from ultra-high resolution in vivo MRI
    Koen Van Leemput
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Hippocampus 19:549-57. 2009
    ..Unlike manual segmentations, our automated technique is fully reproducible, and fast enough to enable routine analysis of the hippocampal subfields in large imaging studies...
  71. pmc The regulation of organ size in Drosophila: physiology, plasticity, patterning and physical force
    Alexander W Shingleton
    Department of Zoology, Michigan State University, East Lansing, MI, USA
    Organogenesis 6:76-87. 2010
    The correct regulation of organ size is a fundamental developmental process, the failure of which can compromise organ function and organismal integrity...
  72. ncbi Chronic high-carbohydrate, high-fat feeding in rats induces reversible metabolic, cardiovascular, and liver changes
    Hemant Poudyal
    School of Biomedical Sciences, The University of Queensland, Brisbane, Australia
    Am J Physiol Endocrinol Metab 302:E1472-82. 2012
    ..These results suggest that chronic H diet feeding for 32 wk mimics the diet-induced cardiovascular and metabolic changes in middle age and that chia seed may serve as an alternative dietary strategy in the management of these changes...
  73. ncbi Levels of serotonin, sclerostin, bone turnover markers as well as bone density and microarchitecture in patients with high-bone-mass phenotype due to a mutation in Lrp5
    Morten Frost
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    J Bone Miner Res 26:1721-8. 2011
    ..The phenotype appeared to progress with age, but BTM did not suggest increased bone formation...
  74. ncbi A microRNA-transcription factor module regulates lateral organ size and patterning in Arabidopsis
    Clayton T Larue
    Division of Biological Sciences, Bond Life Sciences Center and Interdisciplinary Plant Group, University of Missouri Columbia, Columbia, MO 65211, USA
    Plant J 58:450-63. 2009
    ..Therefore, we propose that miRNA164 and CUC2 form a central regulatory module that acts as a governor of lateral organ patterning and expansion...
  75. pmc Effect of constitution on mass of individual organs and their association with metabolic rate in humans--a detailed view on allometric scaling
    Manfred J Muller
    Institut fur Humanernahrung und Lebensmittelkunde, Christian Albrechts Universitat zu Kiel, Kiel, Germany
    PLoS ONE 6:e22732. 2011
    ..These data are the first evidence that constitution adds to the complexity of REE. Since organs scale differently as weight as well as height the "fit" of organ masses within constitution should be considered as a further trait...
  76. pmc Genetic modulation of striatal volume by loci on Chrs 6 and 17 in BXD recombinant inbred mice
    G D Rosen
    Division of Behavioral Neurology, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Genes Brain Behav 8:296-308. 2009
    ..Using bioinformatic tools and the corresponding expression database, we have identified positional candidates in these quantitative trait locus intervals...
  77. pmc NF-κB inhibition protects against tumor-induced cardiac atrophy in vivo
    Ashley Wysong
    Duke University School of Medicine, Durham, North Carolina, USA
    Am J Pathol 178:1059-68. 2011
    ....
  78. ncbi A longitudinal study of gray matter volume decline with age and modifying factors
    Yasuyuki Taki
    Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, 4 1 Seiryocho, Aobaku, Sendai 980 8575, Japan
    Neurobiol Aging 32:907-15. 2011
    ..The APC(GMR) of younger women was lower than that in older women and men. Our results may help in understanding the mechanism(s) of normal brain aging, and in distinguishing neurodegenerative diseases from normal aging...
  79. ncbi A mouse model for spondyloepiphyseal dysplasia congenita with secondary osteoarthritis due to a Col2a1 mutation
    Christopher T Esapa
    Academic Endocrine Unit, Nuffield Department of Clinical Medicine, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Headington, Oxford, United Kingdom
    J Bone Miner Res 27:413-28. 2012
    ..Thus, an ENU mouse model with a Ser1386Pro mutation of the Col2a1 C-propeptide domain that results in abnormal collagen processing and phenotypic features consistent with SEDC and secondary osteoarthritis has been established...
  80. pmc Autosomal recessive primary microcephaly (MCPH): a review of clinical, molecular, and evolutionary findings
    C Geoffrey Woods
    Department of Medical Genetics, Cambridge Institute for Medical Research, Cambridge, United Kingdom
    Am J Hum Genet 76:717-28. 2005
    ..So an understanding of this rare genetic disorder may offer us significant insights into neurogenic mitosis and the evolution of the most striking differences between us and our closest living relatives: brain size and cognitive ability...
  81. pmc Chronic alcohol exposure stimulates adipose tissue lipolysis in mice: role of reverse triglyceride transport in the pathogenesis of alcoholic steatosis
    Wei Zhong
    Department of Nutrition, University of North Carolina at Greensboro, Greensboro, North Carolina 28081, USA
    Am J Pathol 180:998-1007. 2012
    ..3-fold. These data demonstrate for the first time that adipose triglycerides due to alcohol-induced hyperlipolysis are reverse transported and deposited in the liver...
  82. pmc The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals
    Nailing Zhang
    Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Dev Cell 19:27-38. 2010
    The conserved Hippo signaling pathway regulates organ size in Drosophila and mammals...
  83. ncbi Brain size predicts the success of mammal species introduced into novel environments
    Daniel Sol
    Centre for Ecological Research and Applied Forestries, Autonomous University of Barcelona, E 08193 Bellaterra, Catalonia, Spain
    Am Nat 172:S63-71. 2008
    ..Our results replicate similar findings in birds, increasing the generality of evidence for the idea that enlarged brains can provide a survival advantage in novel environments...
  84. pmc Maternal protein restriction leads to hyperresponsiveness to stress and salt-sensitive hypertension in male offspring
    Robert A Augustyniak
    Department of Medicine, Wayne State University, Detroit, MI, USA
    Am J Physiol Regul Integr Comp Physiol 298:R1375-82. 2010
    ..Collectively, these may predispose for the development of hypertension later in life...
  85. pmc Ajuba LIM proteins are negative regulators of the Hippo signaling pathway
    Meghna Das Thakur
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Curr Biol 20:657-62. 2010
    ..dJub by RNA interference identify djub as an essential gene for development and a novel regulator of epithelial organ size as a component of the conserved Hippo (Hpo) pathway, which has been implicated in both tissue size control and ..
  86. pmc The Arabidopsis GRF-INTERACTING FACTOR gene family performs an overlapping function in determining organ size as well as multiple developmental properties
    Byung Ha Lee
    Department of Biology, Kyungpook National University, Daegu 702 701, Korea
    Plant Physiol 151:655-68. 2009
    ....
  87. ncbi Structural brain abnormalities in the frontostriatal system and cerebellum in pedophilia
    Boris Schiffer
    Department of Forensic Psychiatry, University Hospital Essen, University of Duisburg Essen, Virchowstrasse 174, D 45147 Essen, Germany
    J Psychiatr Res 41:753-62. 2007
    ..In this respect these findings may support the hypothesis that there is a shared etiopathological mechanism in all obsessive-compulsive spectrum disorders...
  88. ncbi Glutamine protects ischemia-reperfusion induced acute lung injury in isolated rat lungs
    Chung Kan Peng
    Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan
    Pulm Pharmacol Ther 24:153-61. 2011
    ..Our study showed that glutamine treatment decreased IR-induced acute lung injury. The protective mechanism may be due to the inhibition of NF-κB activation and the attenuation of oxidative stress...
  89. ncbi Reduced olfactory bulb volume and olfactory sensitivity in patients with acute major depression
    S Negoias
    Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, Dresden, Germany
    Neuroscience 169:415-21. 2010
    ..These results might be related to reduced neurogenesis in major depression that could be reflected also at the level of the olfactory bulb...
  90. ncbi Genetic models in applied physiology: selected contribution: effects of spaceflight on immunity in the C57BL/6 mouse. II. Activation, cytokines, erythrocytes, and platelets
    Daila S Gridley
    Department of Radiation Medicine, Division of Microbiology and Molecular Genetics, Loma Linda University and Medical Center, Loma Linda, California 92354, USA
    J Appl Physiol 94:2095-103. 2003
    ..05) and were consistent with dehydration. These data indicate that relatively short exposure to the spaceflight environment can induce profound changes that may become significant during long-term space missions...
  91. ncbi Captivity selects for smaller eyes
    Shengjiang Tan
    Curr Biol 15:R540-2. 2005
  92. pmc Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass
    Enrico Petretto
    Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK
    Nat Genet 40:546-52. 2008
    ..Taken together, these data implicate Ogn as a key regulator of LVM in rats, mice and humans, and suggest that Ogn modifies the hypertrophic response to extrinsic factors such as hypertension and aortic stenosis...
  93. pmc A blunted cortisol awakening response and hippocampal atrophy in type 2 diabetes mellitus
    Hannah Bruehl
    NYU School of Medicine, Department of Psychiatry, New York, NY 10016, USA
    Psychoneuroendocrinology 34:815-21. 2009
    ..Across all subjects, fasting insulin and hippocampal volume were associated with the CAR, independent of diagnosis. Our findings support the hypothesis that hippocampal integrity is an important predictor of the CAR...
  94. pmc A common RET variant is associated with reduced newborn kidney size and function
    Zhao Zhang
    McGill University Health Centre Research Institute, Montreal Quebec, Canada
    J Am Soc Nephrol 19:2027-34. 2008
    ..Whether this gene variant affects clinical outcomes requires further study...
  95. ncbi Prostate size and risk of high-grade, advanced prostate cancer and biochemical progression after radical prostatectomy: a search database study
    Stephen J Freedland
    Department of Urology, Johns Hopkins School of Medicine, 600 N Wolfe St, Baltimore, MD 21287 2101, USA
    J Clin Oncol 23:7546-54. 2005
    ..We examined whether prostate weight was associated with tumor grade, advanced disease, or risk of biochemical progression after radical prostatectomy (RP)...
  96. ncbi Effects of acute dehydration on brain morphology in healthy humans
    Matthew J Kempton
    Centre for Neuroimaging Sciences, Institute of Psychiatry, King s College London, London, United Kingdom
    Hum Brain Mapp 30:291-8. 2009
    ....
  97. ncbi Protective role of lycopene on cisplatin-induced changes in sperm characteristics, testicular damage and oxidative stress in rats
    Ahmet Atessahin
    Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Firat University, 23119 Elazig, Turkey
    Reprod Toxicol 21:42-7. 2006
    ....
  98. pmc Diarylheptanoid phytoestrogens isolated from the medicinal plant Curcuma comosa: biologic actions in vitro and in vivo indicate estrogen receptor-dependent mechanisms
    Wipawee Winuthayanon
    Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand
    Environ Health Perspect 117:1155-61. 2009
    ..Diarylheptanoids isolated from Curcuma comosa Roxb. have been recently identified as phyto estrogens. However, the mechanism underlying their actions has not yet been identified...
  99. ncbi Resting metabolic rate and morphology in mice (Mus musculus) selected for high and low food intake
    C Selman
    Aberdeen Centre for Energy Regulation and Obesity, Department of Zoology, University of Aberdeen, Aberdeen AB24 2TZ, UK
    J Exp Biol 204:777-84. 2001
    ..The effects of strain on RMR independent of the effect on body mass were consistent with the anticipated effect from the strain differences in the size of the liver...
  100. pmc Relation of cardiovascular risk factors to right ventricular structure and function as determined by magnetic resonance imaging (results from the multi-ethnic study of atherosclerosis)
    Harjit Chahal
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Cardiol 106:110-6. 2010
    ..Cardiovascular risk factors, especially blood pressure and high-density lipoprotein cholesterol, are associated with subclinical changes in the RV mass and volume...
  101. ncbi Neurotoxicological effects and the impairment of spatial recognition memory in mice caused by exposure to TiO2 nanoparticles
    Renping Hu
    Medical College of Soochow University, Suzhou, People s Republic of China
    Biomaterials 31:8043-50. 2010
    ..Therefore, the application of TiO(2) NPs and exposure effects especially on human brain for long-term and low-dose treatment should be cautious...

Research Grants63

  1. REGULATION OF MYOCARDIAL GROWTH AND DEATH BY THE HIPPO PATHWAY
    Junichi Sadoshima; Fiscal Year: 2013
    ..Mst1, belongs to a signaling cascade termed the hippo pathway, which plays an important role in regulating organ size through stimulation of apoptosis and suppression of cell proliferation...
  2. Control of cell number in developing retina
    Duojia Pan; Fiscal Year: 2013
    ..and Yki constitute an analogous kinase cascade and that the mammalian Hippo pathway plays a conserved role in organ size control...
  3. Steroid-Dependent Changes in the Yorkie Interactome
    Alexey Veraksa; Fiscal Year: 2013
    ..The Hippo (or alvador/Warts/Hippo, SWH) pathway is a well-conserved metazoan signaling cascade that restricts organ size in the fruit fly Drosophila melanogaster and limits tumorigenesis in mammals...
  4. Cadherin-catenin Mediated Contact Inhibition of Cell Growth
    Barry M Gumbiner; Fiscal Year: 2013
    ..The Hippo pathway was originally discovered as a regulator of organ size in Drosophila embryos, and recently has been shown to regulate mammalian cell growth, contact inhibition, and ..
  5. TLR-mediated Signaling Complex Formation and Regulation of Effector Functions
    Hans Haecker; Fiscal Year: 2012
    ..Preliminary analysis of ABIN-1 deficient mice indicates an inflammatory phenotype with increased lymphoid organ size. PUBLIC HEALTH RELEVANCE: Toll-like receptor family members constitute a major pathogen recognition system, ..
  6. Role of the Hippo Pathway in Pancreas Development
    Nicholas George; Fiscal Year: 2012
    ..The Hippo pathway is a kinase pathway responsible for maintaining proper organ size through its negative effect on Yap, a transcriptional co-activator responsible for stimulating cell ..
  7. Suppression of tadpole limbs: a model for organ size regulation
    RICHARD ELINSON; Fiscal Year: 2009
    ..Organ sizes generally vary with body size, although there are indicators of local organ size regulation as well...
  8. INITIAL EVENTS IN PHOTORECEPTOR SIGNALING
    Joanne Chory; Fiscal Year: 2013
    ..array of phenotypic plasticity because most plant organs do not arise until after the seed germinates, allowing organ size and shape to be optimized to the local environment...
  9. Contribution of Organ Size to Adaptive Thermogenesis during Caloric Restriction
    Wei Shen; Fiscal Year: 2013
    ..b>Organ size based REE prediction models are more accurate than FFM based models...
  10. GENETIC ANALYSIS OF CONVERGENT EXTENSION IN ZEBRAFISH
    Lilianna Solnica-Krezel; Fiscal Year: 2013
    ..In addition, Fat genes have been implicated in control of organ size and recently emerged as candidates for tumor suppressor genes...
  11. Dynein light chain 1 (Dlc1) regulates growth in Drosophila melanogaster
    DANIEL A BARRON; Fiscal Year: 2013
    ..a previously undescribed phenotype whereby 'knocking down'Dlc1 protein with an RNAi transgene reduces organ size. This phenotype offers a unique opportunity to genetically dissect the growth regulatory function of Dlc1...
  12. Role of Hippo-YAP Pathway in Smooth Muscle Phenotypic Modulation
    Jiliang Zhou; Fiscal Year: 2013
    ..pathway is evolutionarily conserved from Drosophila to mammals and plays a critical role in controlling organ size and tumorigenesis by regulating cell proliferation and apoptosis...
  13. EPITHELIAL MORPHOGENESIS IN DEVELOPMENT AND DISEASE
    GREGORY LONGMORE; Fiscal Year: 2013
    ..We have shown that djub is an essential gene and a novel regulator of epithelial organ size as a component of the Hippo signaling pathway...
  14. Decoding the MST1 and MST2 kinases in cellular physiology and tumor suppression
    Nabeel Bardeesy; Fiscal Year: 2013
    ..the transcriptional coactivator, Yorkie, whose human ortholog, Yap, is an established oncogene and regulator of organ size. By generating Mst1/2 KO mice we found that Mst1 and Mst2 are required to maintain quiescence of liver cells and ..
  15. Inductive properties of the dermal papilla of the hair follicle
    Bruce A Morgan; Fiscal Year: 2013
    ..this work will provide insight into the mechanisms by which a progenitor pool interacts with and molds its niche and how that niche contributes to the regulation organ size and shape in the context of the changing needs of the organism.
  16. Mechanisms of Drosophila Tumor Suppression
    David Bilder; Fiscal Year: 2013
    ..has provided both mechanistic insight into known pathways as well as the identification of completely new organ size control pathways that appear conserved in vertebrates...
  17. Mechanisms of cell contact inhibition and their dysregulation in cancer.
    JOSEPH KISSIL; Fiscal Year: 2013
    ..While these pathways play critical roles in regulation of cell proliferation, organ size control and tissue repair, it is still not clear which of these pathways mediates Merlin's tumor ..
  18. Hippo signaling and the control of epidermal development and growth
    Fernando Camargo; Fiscal Year: 2013
    ..The Drosophila Hippo pathway regulates organ size through regulation of the transcriptional activator Yorkie...
  19. Activation mechanism of the tumor-suppressing MST-LATS kinase cascade
    Xuelian Luo; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The Hippo pathway regulates organ size and suppresses tumorigenesis in multicellular organisms. Dysregulation of this pathway drives tumor formation in humans and mice...
  20. DYNAMIC PATTERN IN CHEMICALLY REACTING SYSTEMS
    Hans G Othmer; Fiscal Year: 2013
    ..of basic processes in developmental biology such as signal transduction, pattern formation and the control of organ size in developing systems...
  21. Mechanisms of Mitotic Spindle Orientation in Mammalian Cells
    Quansheng Du; Fiscal Year: 2011
    ..Coordinated cell polarization and spindle orientation plays critical roles during morphogenesis in regulating organ size and shape...
  22. Regulation and function of the YAP transcription co-activator oncoprotein
    Kun Liang Guan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The Hippo tumor suppressor pathway functions to limit tissue growth and organ size by inhibiting proliferation and inducing apoptosis. Dysregulation of the Hippo pathway contributes to tumorigenesis...
  23. REGULATION OF CELL AND ORGAN SIZE IN VIVO
    Iswar K Hariharan; Fiscal Year: 2012
    This project is aimed at understanding the genetic pathways that tissue growth and organ size in vivo...
  24. Genetic Analysis of the Hippo Signaling Pathway in the Mouse Mammary Gland
    Randy L Johnson; Fiscal Year: 2010
    How animals regulate organ size is unknown. Recent studies in Drosophila point towards a novel signaling pathway called "hippo" as an important regulator of organ growth...
  25. Regulation of Active and Quiescent Intestinal Stem Cells
    Kelley Yan; Fiscal Year: 2013
    ..the hypothesis that these ISC populations are regulated by distinct sets of extracellular signals involved in organ size control and oxygen-sensing...
  26. Regulation of the Hippo pathway and its role in uveal melanoma
    Kun Liang Guan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The Hippo tumor suppressor pathway plays a crucial role in regulating organ size by inhibiting cell proliferation and promoting apoptosis, and limitin stem/progenitor cell self- renewal and expansion...
  27. Expanding Objective CT-based Phenotyping to Lungs with Enhanced Radiodensities
    Reinhard R Beichel; Fiscal Year: 2013
    ..such approaches were considered as too computationally demanding for lung image analysis because of the large organ size. We will address this issue by utilizing general-purpose computation on graphics processing hardware techniques, ..
  28. The role of the Hippo pathway on mammalian organ size, progenitor cells and cance
    Thijn Brummelkamp; Fiscal Year: 2013
    The Drosophila Hippo pathway regulates organ size through regulation of the transcriptional activator Yorkie. Interestingly, expression of the mammalian ortholog of Yorkie, YAP1, is enriched in stem cells and amplified in cancer...
  29. YAP1 Regulation of cardiomyocyte proliferation, function, and regeneration
    WILLIAM TSWENCHING PU; Fiscal Year: 2013
    ..that the transcriptional co-regulator YAP1 is a fundamentally important regulator of cellular proliferation and organ size. Recent studies from our lab and others indicate that YAP1 critically regulates heart growth by promoting ..
  30. The Hippo Tumor Suppressor Network: From Organ Size Control to Stem Cells and Can
    David L Woodland; Fiscal Year: 2013
    ..Support is requested for a Keystone Symposia meeting entitled The Hippo Tumor Suppressor Network: From Organ Size Control to Stem Cells and Cancer, organized by Marius Sudol, Helen McNeill, Georg A...
  31. PHOSPHOINOSITIDE-3 KINASE IN CARDIAC HYPERTROPHY
    Peter Kang; Fiscal Year: 2004
    ..overall animal size in mammals, the link between IGF1 and the PI3K pathway in determining individual cell and organ size has not been established...
  32. FETAL NUTRIENT THERAPY: EFFECTS ON GROWTH RETARDATION
    Valerie Charlton; Fiscal Year: 1992
    ..umbilical, uteroplacental and placental uptake of substrates; placental composition and cellularity; and fetal organ size, composition, cellularity and maturity...
  33. Coordination of growth and patterning during development
    Laura Johnston; Fiscal Year: 2007
    ..we will use a series of genetic and molecular assays to understand the intrinsic genetic program that regulates organ size. Our experiments will address how developing organs monitor their mass, how cells sense growth rate differences ..
  34. AGING IN THE SENSORY NERVOUS SYSTEM
    KATHRYN ALBERS; Fiscal Year: 2000
    ..Following induction, measures of sensory end organ size, number, and axonal integrity will be made using immunolabeling analysis...
  35. Magnetic Resonance Microimaging System
    Joel Morrisett; Fiscal Year: 2005
    ..a wide range of in vivo experiments including measurements of blood flow dynamics, tissue fat content, bone and organ size/morphology, and atherosclerotic plaque composition...
  36. Molecular Regulation of Pancreas Cell Fate Determination
    BEN STANGER; Fiscal Year: 2007
    ..Practically, an understanding of the mechanisms by which the organism specifies such cell types may confer the ability to experimentally manipulate tissues for therapy. ..
  37. Notch Signaling and Cell Fate in Embryonic and Adult Liver
    BEN STANGER; Fiscal Year: 2008
    ..As a first step, Notch signaling will be studied to understand how this essential signaling pathway functions during liver development and in the normal function of the liver. [unreadable] [unreadable]..
  38. NEURAL CORRELATES OF AGE RELATED DIFFERENCES IN MEMORY
    Naftali Raz; Fiscal Year: 2003
    ....
  39. ETHANOL EFFECTS ON BONE FORMATION IN PREGNANCY
    Martin Ronis; Fiscal Year: 2006
    ..The role of CYP2E1 and free radicals in the skeletal toxicity of ethanol during these periods will also be studied. ..
  40. ETHANOL METABOLISM IN PREGNANCY--ROLE OF DIET
    Martin Ronis; Fiscal Year: 2005
    ....
  41. SIZE-CONTROL MECHANISMS IN DROSOPHILA DEVELOPMENT
    Duojia Pan; Fiscal Year: 2005
    ..One gene that regulates organ size is dPTEN, a Drosophila homolog of the human PTEN tumor suppressor gene, which encodes a protein with both ..
  42. MOLECULAR BASIS OF CELL GROWTH CONTROL BY THE TOR KINASE
    Joseph Avruch; Fiscal Year: 2011
    ..The results of these studies will provide basis for therapeutic interventions in this pathway, which is crucial to both human cancers and to diseases like Type 2 diabetes ..
  43. Function of the Small GTPase Rheb in Cell Growth
    Duojia Pan; Fiscal Year: 2008
    ..These studies should not only help us understand basic developmental mechanisms, but also provide insights into human diseases and cancer. ..
  44. Hemodynamic predictors of brain and cognitive aging
    Naftali Raz; Fiscal Year: 2005
    ....
  45. Neuroimaging in Depression Treatment Studies
    Yvette Sheline; Fiscal Year: 2006
    ..abstract_text> ..
  46. CHRONIC COCAINE ABUSE EFFECTS ON P50 AND P3A ERPS
    George Fein; Fiscal Year: 2001
    ..Finally, samples of active cocaine abusers will be studied. ..
  47. Androgen Receptor in Prostate Cancer and Bone
    Chawnshang Chang; Fiscal Year: 2005
    ..The success of this proposal will allow a better understanding of the role of androgen in the metastatic spread of prostate cancer to bone and the molecular mechanism of bone remodeling by prostate cancer cells. ..
  48. DRUGS AND DEVELOPMENT OF THE ADRENERGIC NERVOUS SYSTEM
    Theodore Slotkin; Fiscal Year: 2003
    ....
  49. Assessment of Tissue Response to Stress
    Joan Sanders; Fiscal Year: 2006
    ..this technology could be applied to other areas of rehabilitation, for example, shoe design for patients with insensate feet, cushion design for wheelchair users, and mattress design for bedridden patients [unreadable] [unreadable]..
  50. EXERCISE EFFECTS ON PROTEIN METABOLISM
    Robert Wolfe; Fiscal Year: 2002
    ..The results of this study will also contribute to our understanding of the mechanism whereby nutritional intake affects muscle protein metabolism. ..
  51. Acuson Sequoia Ultrasonograph
    Brian Hoit; Fiscal Year: 2003
    ....
  52. Symposium for Molecular and Therapeutic Insights in PKD
    Arlene Chapman; Fiscal Year: 2002
    ..Day 5 will be devoted to autosomal recessive kidney diseases and the last half day will be devoted to potential therapeutic strategies in cystic disorders of the kidney. ..
  53. Signaling in Thymocyte Selection
    Gerald R Crabtree; Fiscal Year: 2010
    ..O -'' :6O a"0-5)'' Q.. C^' ::9 4-- >,O E-- o-0 >-O c(6 fl.. 0)0-0_0 .- ((D 1/. o0' :t- can --0 a)- 4)a) 0-Q iii= L"- -P) .-.. (II o( 'nom 0-a ..
  54. Interaction of Nutrient & Organochlorine Absorption
    Patrick Tso; Fiscal Year: 2010
    ..The proposed research is important because of the biological and clinical importance of OCs in health and disease and they provide considerable new insights into how OCs are carried and delivered to the various organs in the body. ..
  55. ROLE OF MYOSTATIN IN CACHEXIA
    Se Jin Lee; Fiscal Year: 2005
    ..abstract_text> ..
  56. Characterization of myostatin and GDF-11
    Se Jin Lee; Fiscal Year: 2007
    ..abstract_text> ..
  57. Nitric oxide and superoxide effects on the failing heart
    Yingjie Chen; Fiscal Year: 2006
    ..Additional studies will determine whether mRNA and protein expression and activity for eNOS, nNOS, iNOS, CuZn-SOD, Mn-SOD and Ec-SOD are altered in coronary vessels and myocardium by the presence of CHF. ..
  58. EFFECTS OF ALCOHOL ABUSE ON THE AGING BRAIN
    George Fein; Fiscal Year: 2004
    ..g., brain "functional reserve," presence of the APOE-epsilon4 allele) that may modulate the effects of chronic alcohol abuse/dependence and age on brain structure and function. ..
  59. Winter Neuropeptides Conference
    Curt Sandman; Fiscal Year: 2004
    ..The conference is inclusive for all groups. Half of the organizing and steering committees are women. Efforts are made to include minorities and persons with disabilities. ..
  60. Functional Neuroimaging of Cognitive Dysfunction in HIV-HCV Co-Infection
    Robert Paul; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  61. MECHANISMS OF CHLORPYRIFOS DEVELOPMENTAL NEUROTOXICITY
    Theodore Slotkin; Fiscal Year: 2004
    ..Molecular mechanisms of developmental neurotoxicity can be determined and linked to eventual alterations in behavioral performance. ..
  62. Treatment Outcome of Vascular Depression
    Yvette Sheline; Fiscal Year: 2005
    ..The proposed trial will provide information of value to the practitioner and also provide data to build a more comprehensive model of the prognostic impact of frontal-subcortical brain changes on the outcome of late-life depression. ..
  63. AR-ASSOCIATED PROTEINS IN PROSTATE CARCINOGENESIS
    Chawnshang Chang; Fiscal Year: 2001
    ..As a result, ultimately, we might find a potential protocol to manage the progression of CaP in the clinic. ..