blood preservation

Summary

Summary: The process by which blood or its components are kept viable outside of the organism from which they are derived (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).

Top Publications

  1. ncbi Flow cytometric measurement of microparticles: pitfalls and protocol modifications
    Mona D Shah
    Baylor College opf Medicine, Texas Children s Cancer Center and Hematology Service, Texas Children s Hospital, Houston, Texas 77030, USA
    Platelets 19:365-72. 2008
  2. ncbi Clinical consequences of red cell storage in the critically ill
    Alan Tinmouth
    Center for Transfusion and Critical Care Research, Clinical Epidemiology Unit, Critical Care Program, University of Ottawa and Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Transfusion 46:2014-27. 2006
  3. ncbi Vesicles generated during storage of red cells are rich in the lipid raft marker stomatin
    Ulrich Salzer
    Department of Vascular Biology and Thrombosis Research, Medical University of Vienna, Vienna, Austria
    Transfusion 48:451-62. 2008
  4. ncbi Effects of storage time of red blood cell transfusions on the prognosis of coronary artery bypass graft patients
    Leo van de Watering
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Transfusion 46:1712-8. 2006
  5. ncbi The red cell storage lesion and its implication for transfusion
    I Chin-Yee
    Department of Haematology, London Health Sciences Centre, University of Western Ontario, Canada
    Transfus Sci 18:447-58. 1997
  6. ncbi Stored red blood cells: a changing universe waiting for its map(s)
    Niels Lion
    Service Régional Vaudois de Transfusion Sanguine, Lausanne, Switzerland
    J Proteomics 73:374-85. 2010
  7. pmc Transfusion of red blood cells after prolonged storage produces harmful effects that are mediated by iron and inflammation
    Eldad A Hod
    Department of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Blood 115:4284-92. 2010
  8. ncbi Genotyping whole-genome-amplified DNA from 3- to 25-year-old neonatal dried blood spot samples with reference to fresh genomic DNA
    Mads Vilhelm Hollegaard
    Section of Neonatal Screening and Hormones, Statens Serum Institute, Copenhagen, Denmark
    Electrophoresis 30:2532-5. 2009
  9. ncbi Platelet storage lesion: an update on the impact of various leukoreduction processes on the biological response modifiers
    Jerard Seghatchian
    Blood Component Technology and Thrombosis Haemostasis Consultancy, 50 Primrose Hill Road, London NW3 3AA, UK
    Transfus Apher Sci 34:125-30. 2006
  10. ncbi RBC-derived vesicles during storage: ultrastructure, protein composition, oxidation, and signaling components
    Anastasios G Kriebardis
    Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, Greece
    Transfusion 48:1943-53. 2008

Detail Information

Publications230 found, 100 shown here

  1. ncbi Flow cytometric measurement of microparticles: pitfalls and protocol modifications
    Mona D Shah
    Baylor College opf Medicine, Texas Children s Cancer Center and Hematology Service, Texas Children s Hospital, Houston, Texas 77030, USA
    Platelets 19:365-72. 2008
    ..These results illustrate the need to standardize assay protocols in order to obtain consistent measurements. Our studies further optimize sample preparation for microparticle detection...
  2. ncbi Clinical consequences of red cell storage in the critically ill
    Alan Tinmouth
    Center for Transfusion and Critical Care Research, Clinical Epidemiology Unit, Critical Care Program, University of Ottawa and Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Transfusion 46:2014-27. 2006
    ..These data suggest a possible detrimental clinical effect associated with the transfusion of stored RBCs; randomized clinical trials further evaluating the clinical consequences of transfusing older stored RBCs are required...
  3. ncbi Vesicles generated during storage of red cells are rich in the lipid raft marker stomatin
    Ulrich Salzer
    Department of Vascular Biology and Thrombosis Research, Medical University of Vienna, Vienna, Austria
    Transfusion 48:451-62. 2008
    ..The characterization of the vesicular membrane might hint at the underlying mechanism of the storage-associated changes in general and the vesiculation process in particular...
  4. ncbi Effects of storage time of red blood cell transfusions on the prognosis of coronary artery bypass graft patients
    Leo van de Watering
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Transfusion 46:1712-8. 2006
    ..The aim in this study was to investigate the possible role of the storage time of RBC transfusions on the outcome of coronary artery bypass graft (CABG) surgery patients...
  5. ncbi The red cell storage lesion and its implication for transfusion
    I Chin-Yee
    Department of Haematology, London Health Sciences Centre, University of Western Ontario, Canada
    Transfus Sci 18:447-58. 1997
    ..We review evidence for those storage related changes and potential clinical implications for red blood cell transfusion...
  6. ncbi Stored red blood cells: a changing universe waiting for its map(s)
    Niels Lion
    Service Régional Vaudois de Transfusion Sanguine, Lausanne, Switzerland
    J Proteomics 73:374-85. 2010
    ....
  7. pmc Transfusion of red blood cells after prolonged storage produces harmful effects that are mediated by iron and inflammation
    Eldad A Hod
    Department of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Blood 115:4284-92. 2010
    ..Nonetheless, these findings must be confirmed by prospective human studies...
  8. ncbi Genotyping whole-genome-amplified DNA from 3- to 25-year-old neonatal dried blood spot samples with reference to fresh genomic DNA
    Mads Vilhelm Hollegaard
    Section of Neonatal Screening and Hormones, Statens Serum Institute, Copenhagen, Denmark
    Electrophoresis 30:2532-5. 2009
    ..Based on these results we conclude that DBS samples should be considered a reliable and potential resource for future genotyping studies...
  9. ncbi Platelet storage lesion: an update on the impact of various leukoreduction processes on the biological response modifiers
    Jerard Seghatchian
    Blood Component Technology and Thrombosis Haemostasis Consultancy, 50 Primrose Hill Road, London NW3 3AA, UK
    Transfus Apher Sci 34:125-30. 2006
    ....
  10. ncbi RBC-derived vesicles during storage: ultrastructure, protein composition, oxidation, and signaling components
    Anastasios G Kriebardis
    Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, Greece
    Transfusion 48:1943-53. 2008
    ..The vesiculation of the RBCs is a part of the storage lesion. The protein composition of the vesicles generated during storage of banked RBCs has not been studied in detail...
  11. ncbi Effects of age of transfused blood on length of stay in trauma patients: a preliminary report
    Mary E Keller
    Department of Surgery, Boston University Medical Center, Massachusetts 02118, USA
    J Trauma 53:1023-5. 2002
  12. ncbi Cryopreservation of living cells: principles and practice
    Harold T Meryman
    Laboratory for Cryobiology and Biophysics, Biomedical Research Institute, Rockville, Maryland 20852, USA
    Transfusion 47:935-45. 2007
    ..Finally, the article summarizes the five different approaches to applied cryopreservation: ultrarapid freezing and thawing, controlled-rate freezing, freezing with nonpenetrating polymers, vitrification, and equilibrium freezing...
  13. pmc Reducing noninfectious risks of blood transfusion
    Brian M Gilliss
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143 0624, USA
    Anesthesiology 115:635-49. 2011
    ....
  14. ncbi Red blood cells intended for transfusion: quality criteria revisited
    Claes F Högman
    Division of Clinical Immunology and Transfusion Medicine, Academic Laboratory, University Hospital, Uppsala, Sweden
    Transfusion 46:137-42. 2006
    ..The ideal storage protocol would require sterile, high-pH solutions containing both glucose and electrolytes...
  15. pmc Evolution of adverse changes in stored RBCs
    Elliott Bennett-Guerrero
    Department of Anesthesiology, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 104:17063-8. 2007
    ....
  16. ncbi Elastic properties of irradiated RBCs measured by optical tweezers
    M L Barjas-Castro
    Hematology and Transfusion Center, State University of Campinas, Sao Paulo, Brazil
    Transfusion 42:1196-9. 2002
    ..Gamma irradiation of RBCs results in the production of reactive oxygen capable of initiating the process of membrane lipid peroxidation and accelerates the leakage of potassium ions from RBCs, resulting in an increase of internal viscosity...
  17. pmc Effects of storage temperature and time on clinical biochemical parameters from rat serum
    Carolyn Cray
    Department of Pathology, University of Miami Miller School of Medicine, Miami, Florida, USA
    J Am Assoc Lab Anim Sci 48:202-4. 2009
    ..Samples stored in frost-free and nonfrost-free -20 degrees C freezers did not differ significantly through day 90. Factors such as storage time and temperature should be considered when designing any retrospective study...
  18. ncbi pH, temperature and lactate production in human red blood cells: implications for blood storage and glycolytic control
    M Guppy
    Biochemistry Department, University of Western Australia, Nedlands
    Vox Sang 62:70-5. 1992
    ..It is generally accepted that hexokinase catalyses the rate-limiting step in glycolysis in the human red cell, but none of the ionizable groups implicated correspond to that involved in the hexokinase reaction...
  19. ncbi Alterations of red blood cell metabolome during cold liquid storage of erythrocyte concentrates in CPD-SAGM
    Federica Gevi
    Department of Ecological and Biological Sciences, Tuscia University, Largo dell Universita, snc, 01100, Viterbo, Italy
    J Proteomics 76:168-80. 2012
    ..This article is part of a Special Issue entitled: Integrated omics...
  20. pmc Identification of lipids that accumulate during the routine storage of prestorage leukoreduced red blood cells and cause acute lung injury
    Christopher C Silliman
    Bonfils Blood Center, and the Department of Surgery, Denver Health Medical, Denver, Colorado 80230, USA
    Transfusion 51:2549-54. 2011
    ....
  21. ncbi Impact of the storage temperature on human plasma proteomic analysis: implications for the use of human plasma collections in research
    María Insenser
    Department of Endocrinology, Hospital Universitario Ramon y Cajal and Universidad de Alcala and Instituto Ramon y Cajal de Investigacion Sanitaria IRYCIS, Spain
    Proteomics Clin Appl 4:739-44. 2010
    ..To analyze the impact of storage temperature on the 2D-DIGE profile of human plasma...
  22. pmc Red blood cell storage in SAGM and AS3: a comparison through the membrane two-dimensional electrophoresis proteome
    Gian Maria D'Amici
    Department of Ecological and Biological Sciences, University of Tuscia, Largo dell Università snc, Viterbo, Italy
    Blood Transfus 10:s46-54. 2012
    ....
  23. ncbi Seven-day storage of apheresis platelets: report of an in vitro study
    Larry J Dumont
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Transfusion 43:143-50. 2003
    ..The objective of this study was to determine the allowable platelet content limits for apheresis platelets stored for 7 days in a platelet storage bag (COBE ELP, Gambro BCT)...
  24. ncbi An improved red blood cell additive solution maintains 2,3-diphosphoglycerate and adenosine triphosphate levels by an enhancing effect on phosphofructokinase activity during cold storage
    Patrick Burger
    Department of Blood Cell Research, Sanquin Research, Amsterdam, The Netherlands
    Transfusion 50:2386-92. 2010
    ..We have previously shown that with a new AS called phosphate-adenine-glucose-guanosine-gluconate-mannitol (PAGGGM), both 2,3-DPG and ATP could be maintained throughout storage for 35 days...
  25. ncbi Duration of red-cell storage and complications after cardiac surgery
    Colleen Gorman Koch
    Department of Cardiothoracic Anesthesia, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    N Engl J Med 358:1229-39. 2008
    ..We tested the hypothesis that serious complications and mortality after cardiac surgery are increased when transfused red cells are stored for more than 2 weeks...
  26. ncbi Release of potential immunomodulatory factors during platelet storage
    Fabrice Cognasse
    EFS Auvergne Loire, Saint Etienne, France
    Transfusion 46:1184-9. 2006
    ..Recent studies have demonstrated that PLTs promote immunity and inflammation mainly by means of the CD40/CD40L pathway. Our objective was to describe the accumulation of cytokines in PLT concentrates during storage...
  27. ncbi Controlled-rate versus uncontrolled-rate cryopreservation of peripheral blood progenitor cells: a prospective multicenter study. Group for Cryobiology and Biology of Bone Marrow Transplantation (CBTMO), Spain
    J Perez-Oteyza
    Department of Hematology, Hospital Ramon y Cajal, Madrid, Spain
    Haematologica 83:1001-5. 1998
    ..In an attempt to elucidate whether both methods are equally efficient, we compared controlled-rate versus uncontrolled cryopreservation of peripheral blood progenitor cells (PBPC) in a prospective, multicenter study...
  28. ncbi Autologous blood transfusion for cardiopulmonary bypass: effects of storage conditions on platelet function
    Ian R Ramnarine
    Department of Cardiac Surgery, Glasgow Royal Infirmary, Glasgow, United Kingdom
    J Cardiothorac Vasc Anesth 20:541-7. 2006
    ..The effects of citrate preservative and heparinization before storage on platelet function was therefore assessed...
  29. ncbi Murine blood banking: characterization and comparisons to human blood
    Amy T Makley
    Department of Surgery, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    Shock 34:40-5. 2010
    ..Characterization of the murine red cell storage lesion will allow the application of stored blood components to future investigations into the treatment of acute anemia in experimental murine models...
  30. ncbi Accumulation of soluble inflammatory mediators between blood donation and pre-storage leucocyte depletion
    D Chudziak
    German Red Cross Blood Centre and Institute for Transfusion Medicine and Immunohaematology of the Johann Wolfgang Goethe University, Frankfurt, Germany
    Vox Sang 96:163-6. 2009
    ..As leucocyte filtration and component separation can be performed until 24 h after donation, we hypothesized that within this time, inflammatory cytokines might accumulate...
  31. ncbi Long-term hematologic reconstitution after autologous peripheral blood progenitor cell transplantation: a comparison between controlled-rate freezing and uncontrolled-rate freezing at 80 degrees C
    Mauro Montanari
    Department of Haematology, University of Ancona, Torrette Hospital, Italy
    Transfusion 43:42-9. 2003
    ..Uncontrolled-rate freezing (URF) at -80 degrees C has also been used, but its clinical impact has not been studied sufficiently yet...
  32. ncbi Blood bank conditions and RBCs: the progressive loss of metabolic modulation
    I Messana
    Institute of Chemistry and Clinical Chemistry, Faculty of Medicine, Catholic University, Rome, Italy
    Transfusion 40:353-60. 2000
    ..The present study investigates the effect of storage on this metabolic modulation and its relationship with the alteration of membrane protein composition...
  33. ncbi Prestorage leukocyte filtration may reduce leukocyte-derived bioactive substance accumulation in patients operated for burn trauma
    H J Nielsen
    Department of Surgical Gastroenterology, Hvidovre University Hospital, Denmark
    Burns 25:162-70. 1999
    ..0 and 2.0. Prestorage leukocyte filtration may reduce transfusion related accumulation of various bioactive substances and the requirement for blood in burn trauma patients...
  34. ncbi Oxygenating the microcirculation: the perspective from blood transfusion and blood storage
    N J H Raat
    Vascular Medicine Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Vox Sang 93:12-8. 2007
    ..A better understanding of hypoxia-induced vasodilator release from RBC might become a potential target for drug development and improve tissue oxygenation after transfusion...
  35. ncbi Supernatant from stored red cells activates neutrophils
    I Chin-Yee
    Department of Hematology, London Health Sciences Centre, University of Western Ontario, Canada
    Transfus Med 8:49-56. 1998
    ..The exceedingly low level of IL8 and TNF alpha found in this study suggests that other factors may play a more important role in neutrophil priming and activation...
  36. pmc Changes in Band 3 oligomeric state precede cell membrane phospholipid loss during blood bank storage of red blood cells
    Brad S Karon
    Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Transfusion 49:1435-42. 2009
    ..The aim of the study was to determine whether changes in the macromolecular organization of membrane proteins occur before, coincident with, or after lipid loss during RBC storage...
  37. ncbi Association between duration of storage of transfused red blood cells and morbidity and mortality in adult patients: myth or reality?
    Christophe Lelubre
    Department of Intensive Care Medicine, Erasme University Hospital, Universite Libre de Bruxelles, Route de Lennik 808, Brussels, Belgium
    Transfusion 49:1384-94. 2009
    ..The duration of red blood cell (RBC) storage before transfusion may alter RBC function and, therefore, influence the incidence of complications...
  38. pmc Red blood cell microparticles show altered inflammatory chemokine binding and release ligand upon interaction with platelets
    Zeyu Xiong
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Transfusion 51:610-21. 2011
    ..Microparticles express the blood group Duffy antigen known to bind multiple inflammatory chemokines, but the functional chemokine binding properties of microparticles are not known...
  39. ncbi Plasma and lipids from stored platelets cause acute lung injury in an animal model
    Christopher C Silliman
    Bonfils Blood Center, 717 Yosemite Circle, Denver, CO 80123, USA
    Transfusion 43:633-40. 2003
    ..We hypothesize that lipids generated during storage of PLTs cause TRALI in a two-event animal model...
  40. ncbi Proteomics meets blood banking: identification of protein targets for the improvement of platelet quality
    Peter Schubert
    Canadian Blood Services, Centre for Blood Research and the Department of Pathology and Laboratory Medicine, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC, Canada
    J Proteomics 73:436-44. 2010
    ....
  41. ncbi Level of platelet-derived cytokines in leukoreduced red blood cells is influenced by the processing method and type of leukoreduction filter
    Kristen M Glenister
    Research Unit, Australian Red Cross Blood Service, Melbourne, Victoria, Australia
    Transfusion 50:185-9. 2010
    ..In this study, the PLT content and level of PLT-derived cytokines in RBCs prepared using different types of leukoreduction methods were investigated...
  42. ncbi In silico modeling and metabolome analysis of long-stored erythrocytes to improve blood storage methods
    Taiko Nishino
    Institute for Advanced Biosciences, Keio University, 403 1, Daihoji, Tsuruoka, Yamagata 997 0017, Japan
    J Biotechnol 144:212-23. 2009
    ..Alterations in the metabolic intermediate concentrations after long storage were qualitatively predicted by the model. Finally, through further systematic analysis, we also discuss the usability of our model...
  43. ncbi Profiling of alterations in platelet proteins during storage of platelet concentrates
    Thomas Thiele
    Institute for Immunology and Transfusion Medicine, Ernst Moritz Arndt University, Greifswald, Germany
    Transfusion 47:1221-33. 2007
    ..In contrast, proteomic technologies provide a comprehensive overview of the PLT proteome. High interassay variability, however, limits meaningful assessment of samples taken from the same product over time or before and after processing...
  44. ncbi Influence of prestorage leukoreduction and subsequent irradiation on in vitro red blood cell (RBC) storage variables of RBCs in additive solution saline-adenine-glucose-mannitol
    Robert Zimmermann
    Department of Transfusion Medicine, University Hospital Erlangen, Erlangen, Germany
    Transfusion 49:75-80. 2009
    ..Reported studies reflect neither the current Food and Drug Administration (FDA) nor the European recommendations on timing of irradiation and subsequent storage...
  45. ncbi Red blood cell aging markers during storage in citrate-phosphate-dextrose-saline-adenine-glucose-mannitol
    Marianna H Antonelou
    Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, Athens, Greece
    Transfusion 50:376-89. 2010
    ..It has been suggested that red blood cell (RBC) senescence is accelerated under blood bank conditions, although neither protein profile of RBC aging nor the impact of additive solutions on it have been studied in detail...
  46. ncbi The proteome of red cell membranes and vesicles during storage in blood bank conditions
    Giel J C G M Bosman
    Department of Biochemistry, the Center for Molecular and Biomolecular Informatics, Nijmegen Center of Molecular Life Sciences, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Transfusion 48:827-35. 2008
    ..To be able to identify the mechanisms underlying these storage lesions, a proteomic analysis of the membranes of RBCs and their vesicles was performed during various periods of storage in blood bank conditions...
  47. ncbi The London Cord Blood Bank: analysis of banking and transplantation outcome
    Sue Davey
    The London Cord Blood Bank, National Blood Service, Colindale Centre, London, UK
    Br J Haematol 125:358-65. 2004
    ..Two years after transplantation the survival rate was 69% and 54% for patients receiving a 6/6 or 5/6 HLA matched units, respectively. Infection was the main cause of transplanted related mortality in these patients...
  48. ncbi Blood collection, shipment, processing, and storage
    Jimmie B Vaught
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard EPS 7030, MSC 7242, Rockville, MD 20892 7242, USA
    Cancer Epidemiol Biomarkers Prev 15:1582-4. 2006
    ....
  49. ncbi Storage of red blood cells with improved maintenance of 2,3-bisphosphoglycerate
    Claes F Högman
    Department of Clinical Immunology and Transfusion Medicine, Academic Laboratory, University Hospital, Uppsala, Sweden
    Transfusion 46:1543-52. 2006
    ..Recent clinical evaluations indicate that the quality of transfused RBCs may be more important for patient survival than previously recognized...
  50. ncbi Multiple electrode aggregometry: a new device to measure platelet aggregation in whole blood
    Orsolya Toth
    Institute for Prevention of Cardiovascular Diseases, University of Munich, Munich, Germany
    Thromb Haemost 96:781-8. 2006
    ..The use of hirudin as an anticoagulant is preferable to the use of citrate. MEA is a promising technique for experimental and clinical applications...
  51. ncbi Extended storage of red blood cells under anaerobic conditions
    T Yoshida
    Biomedical Engineering Department, Boston University College of Engineering, Boston, MA 02465, USA
    Vox Sang 92:22-31. 2007
    ..The in vitro effects of storing red cells under oxygen-depleted conditions for extended periods were investigated, and these were correlated with the observed recoveries after reinfusion...
  52. ncbi Effect of pre-storage gamma irradiation on red blood cells
    P Agarwal
    Department of Transfusion Medicine, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    Indian J Med Res 122:385-7. 2005
    ..The aim of the present study was to assess the biochemical changes during conventional preservation of irradiated and non-irradiated whole blood...
  53. ncbi The how and why of exocytic vesicles
    Tibor J Greenwalt
    Hoxworth Blood Center, Cincinnati, Ohio 45267 0055, USA
    Transfusion 46:143-52. 2006
    ..During storage, this loss of membrane contributes to the storage lesion and the accumulation of the microvesicles are believed to be thrombogenic and thus to be clinically important...
  54. ncbi Storage of equine red blood cells as a concentrate
    Kati Niinistö
    Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, P O Box 57, 00014 Helsinki, Finland
    Vet J 176:227-31. 2008
    ..RBCs deteriorated somewhat during storage, but when compared with human in vitro parameters, remained suitable for transfusion. It is concluded that equine erythrocytes can be stored for at least 35 days before transfusion...
  55. ncbi Progressive oxidation of cytoskeletal proteins and accumulation of denatured hemoglobin in stored red cells
    Anastasios G Kriebardis
    Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, Athens, Greece
    J Cell Mol Med 11:148-55. 2007
    ....
  56. ncbi Rejuvenation treatment of stored red blood cells reverses storage-induced adhesion to vascular endothelial cells
    Alexander Koshkaryev
    Department of Biochemistry, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Transfusion 49:2136-43. 2009
    ..This study was undertaken to examine the possibility of repairing this damage by a poststorage "rejuvenation" procedure before transfusion...
  57. pmc Duration of red blood cell storage is associated with increased incidence of deep vein thrombosis and in hospital mortality in patients with traumatic injuries
    Philip C Spinella
    Department of Pediatrics, Connecticut Children s Medical Center, 282 Washington Street, Hartford, CT 06106, USA
    Crit Care 13:R151. 2009
    ..To determine if duration of RBC storage is associated with adverse outcomes we studied critically ill trauma patients requiring transfusion...
  58. ncbi Transportation of cellular therapy products: report of a survey by the cellular therapies team of the Biomedical Excellence for Safer Transfusion (BEST) collaborative
    D H Pamphilon
    NHS Blood and Transplant, North Bristol Park, Northway, Filton, Bristol, UK
    Vox Sang 99:168-73. 2010
    ..A number of variables such as temperature and cell concentration are of critical importance for the integrity of CTP during this time...
  59. ncbi Effect of prophylactic transfusion of stored RBCs on oxygen reserve in response to acute isovolemic hemorrhage in a rodent model
    D Gray
    Department of Hematology, A.C. Burton Vascular Biology Laboratory, London Health Sciences Centre, 800 Commissioners Road East, London, Ontario, Canada N6A 4G5
    Transfusion 41:950-6. 2001
    ..CONCLUSION: The physiologic impact of DPG depletion in transfused stored blood on oxygen availability in normal rats appears to be small and may be clinically inconsequential...
  60. ncbi Preventing platelet-derived microparticle formation--and possible side effects-with prestorage leukofiltration of whole blood
    Akiko Sugawara
    Division of Blood Transfusion and Transplantation Immunology, Fukushima Medical University, Fukushima City, Japan
    Arch Pathol Lab Med 134:771-5. 2010
    ..Platelet-derived microparticles (PDMPs) probably function in hemostasis, thrombosis, inflammation, and transfusion-related immunomodulation...
  61. ncbi Erythrocyte ageing in vivo and in vitro: structural aspects and implications for transfusion
    G J C G M Bosman
    Department of Biochemistry, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Transfus Med 18:335-47. 2008
    ....
  62. ncbi Age of blood as a limitation for transfusion: potential impact on blood inventory and availability
    Magali J Fontaine
    Department of Pathology, Stanford University School of Medicine, Stanford University Medical Center, 300 Pasteur Drive, Room H1402, M C 5626, Stanford, CA 94305 5626, USA
    Transfusion 50:2233-9. 2010
    ..Evolving concerns about storage lesions for red blood cells (RBCs) have led to ongoing trials evaluating the benefits of transfusing fresher blood to acutely ill patients...
  63. ncbi Effect of 24-hour whole-blood storage on plasma clotting factors
    E M O'neill
    American Red Cross Blood Services, New England Region, Dedham, Massachusetts 02026, USA
    Transfusion 39:488-91. 1999
    ..These requirements, however, limit the production of fresh-frozen plasma in a large blood center. There are few data on the effect of the extension of CPD whole-blood storage to 24 hours on clotting factor activity...
  64. ncbi Usefulness of cord-blood harvesting for autologous transfusion in surgical newborns with antenatal diagnosis of congenital anomalies
    K Imura
    Division of Pediatric Surgery and Obstetrics, Osaka Medical Center for Maternal and Child Health and Research Institute, Osaka, Japan
    J Pediatr Surg 36:851-4. 2001
    ..Adequate collection and storage techniques for cord-blood must be developed. J Pediatr Surg 36:851-854...
  65. pmc Viability and recovery of peripheral blood mononuclear cells cryopreserved for up to 12 years in a multicenter study
    C A Kleeberger
    Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, Maryland 21205, USA
    Clin Diagn Lab Immunol 6:14-9. 1999
    ..Storing 10(7) PBMC per vial yields sufficient viable cells for phenotypic and/or functional analysis. Results from the MACS provide the basis for the planning of future repositories for use by investigators with similar research goals...
  66. ncbi Influence of erythrocyte concentrate storage time on postsurgical morbidity in cardiac surgery patients
    Santiago R Leal-Noval
    Division of Critical Care, Department of Thoracic Surgery, Hospital Universitario Virgen del Rocio, Seville, Spain
    Anesthesiology 98:815-22. 2003
    ..To estimate the role of the duration of storage of erythrocytes on morbidity in cardiac surgery, we performed an observational study...
  67. ncbi The impact of storage on red cell function in blood transfusion
    Emre Almac
    Clinical Physiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Best Pract Res Clin Anaesthesiol 21:195-208. 2007
    ....
  68. ncbi The efficacy of autologous cord-blood transfusions in neonatal surgical patients
    Tomoaki Taguchi
    Department of Pediatric Surgery, Graduate School of Medical Sciences, Kyushu University and The Transfusion Service, Kyushu University Hospital, Fukuoka, Japan
    J Pediatr Surg 38:604-7. 2003
    ..Furthermore, autologous cord-blood transfusions (ACBT) have been reported to be effective for the treatment of anemia in premature infants. The authors examined the efficacy of ACBT in neonatal surgical patients...
  69. ncbi Transfusion of aged packed red blood cells results in decreased tissue oxygenation in critically injured trauma patients
    Laszlo N Kiraly
    Division of Trauma and Critical Care, Department of Surgery, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Trauma 67:29-32. 2009
    ..The transfusion of older blood has been shown to be detrimental in retrospective studies. This study aims to study the effect of the age of the blood transfused on the tissue oxygenation using near infrared spectroscopy...
  70. pmc Standardization of cytokine flow cytometry assays
    Holden T Maecker
    BD Biosciences, San Jose, USA
    BMC Immunol 6:13. 2005
    ....
  71. ncbi Umbilical cord blood collection: do patients really understand?
    Nathan S Fox
    Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Perinat Med 35:314-21. 2007
    ..Some patients also have the option to donate the cord blood to a public bank for anyone to use. We evaluated patient understanding about cord blood banking in a cohort of patients with access to both options...
  72. pmc Duration of red blood cell storage and outcomes in pediatric cardiac surgery: an association found for pump prime blood
    Marco Ranucci
    Department of Cardiothoracic vascular Anesthesia and Intensive Care, IRCCS Policlinico S, Donato, San Donato Milanese, Milan, 20097, Italy
    Crit Care 13:R207. 2009
    ..The purpose of this study was to investigate the influence of red blood cell storage time prior to transfusion on postoperative morbidity in pediatric cardiac operations...
  73. ncbi Influence of storage on red blood cell rheological properties
    Tamara L Berezina
    Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey 07103 2714, USA
    J Surg Res 102:6-12. 2002
    ..We assumed that blood storage was accompanied by a progressive decrease of RBC deformability and rheological disorders. The degree of rheological disturbances should be directly proportional to the number of RBC with altered geometry...
  74. ncbi Transfusion and postoperative pneumonia in coronary artery bypass graft surgery: effect of the length of storage of transfused red cells
    E C Vamvakas
    Blood Transfusion Service, Massachusetts General Hospital, and the Department of Pathology, Harvard Medical School, Boston, USA
    Transfusion 39:701-10. 1999
    ..RBCs transfused after prolonged storage may be associated with a higher incidence of postoperative infections than fresh RBCs. This hypothesis does not seem to have been investigated in a clinical study...
  75. ncbi Does the storage time of transfused red blood cells influence regional or global indexes of tissue oxygenation in anemic critically ill patients?
    Timothy S Walsh
    Department of Anaesthesia, New Edinburgh Royal Infirmary, Edinburgh, Scotland, UK
    Crit Care Med 32:364-71. 2004
    ..The a priori hypothesis was that stored red cells worsen gastric oxygenation...
  76. ncbi Fresh blood and aged stored blood are equally efficacious in immediately reversing anemia-induced brain oxygenation deficits in humans
    Richard B Weiskopf
    Department of Anesthesia and Cardiovascular Research Institute, University of California, San Francisco, USA
    Anesthesiology 104:911-20. 2006
    ..The authors tested the hypothesis that erythrocytes stored for 3 weeks are as effective in supplying oxygen to human tissues as are erythrocytes stored for less than 5 h...
  77. ncbi Length of storage of transfused red cells and postoperative morbidity in patients undergoing coronary artery bypass graft surgery
    E C Vamvakas
    Blood Transfusion Service, Massachusetts General Hospital, and the Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA
    Transfusion 40:101-9. 2000
    ..The association of postoperative morbidity with the length of storage of perioperatively transfused RBCs was studied in 268 consecutive patients receiving a blood transfusion for coronary artery bypass graft surgery...
  78. ncbi Reactivity of blood samples spotted onto filter papers in the WST-8 method for screening of G6PD deficiency
    Meiji Arai
    Division of Medical Zoology, Department of Infection and Immunity, Jichi Medical School, Tochigi 329 0498, Japan
    Acta Med Okayama 60:127-34. 2006
    ....
  79. ncbi Quality and stability of red cells derived from gravity-separated placental blood with a hollow-fiber system
    Thomas Brune
    University Children s Hospital, Magdeburg, Germany
    Transfusion 47:2271-5. 2007
    ..Several studies show that donor red blood cells (RBCs) can be processed by gravity separation with a hollow-fiber filtration system. This study investigated whether fetal blood could be filtered in the same way...
  80. ncbi Effects of storage on efficacy of red cell transfusion: when is it not safe?
    Juliet Ho
    Departmentof Medicine, The University of Western Ontario, London, Canada
    Crit Care Med 31:S687-97. 2003
    ..To review the literature on red blood cell storage and its relationship to the efficacy of transfusion...
  81. ncbi Autologous red cells derived from cord blood: collection, preparation, storage and quality controls with optimal additive storage medium (Sag-mannitol)
    H S P Garritsen
    Department of Transfusion Medicine, Städtisches Klinikum, Braunschweig, Germany
    Transfus Med 13:303-10. 2003
    ..Utilizing a closed collection system for cord blood and an extended storage medium will increase safety and quality and facilitate the routine transfusion of autologous red cells derived from cord blood...
  82. ncbi Stored packed red blood cells contain a procoagulant phospholipid reducible by leukodepletion filters and washing
    Lisa J Cardo
    Department of Blood Research, Transfusion Medicine Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, United States
    Transfus Apher Sci 38:141-7. 2008
    ....
  83. ncbi Current issues relating to the transfusion of stored red blood cells
    A B Zimrin
    Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Vox Sang 96:93-103. 2009
    ..Several large prospective studies of the safety of stored red blood cells are planned...
  84. ncbi Prolonged maintenance of 2,3-diphosphoglycerate acid and adenosine triphosphate in red blood cells during storage
    Dirk de Korte
    Sanquin Research, Amsterdam, The Netherlands
    Transfusion 48:1081-9. 2008
    ..From the literature it is known that the intracellular pH is an important determinant of RBC metabolism. Therefore, a new, alkaline, AS was developed with the aim to allow cold storage of RBCs with stable product characteristics...
  85. ncbi Age of transfused blood: an independent predictor of mortality despite universal leukoreduction
    Jordan A Weinberg
    Center for Injury Sciences, Section of Trauma, Burns, and Surgical Critical Care, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35294 0007, USA
    J Trauma 65:279-82; discussion 282-4. 2008
    ..The purpose of this study was to evaluate the influence of stored blood age on mortality in injured patients who universally received leukoreduced blood...
  86. ncbi The effect of storage on the accumulation of oxidative biomarkers in donated packed red blood cells
    Leonard T Rael
    Swedish Medical Center, Trauma Research Laboratory, Englewood, Colorado 80113, USA
    J Trauma 66:76-81. 2009
    ..Longer storage times of packed red blood cells (PRBC) and other blood products have been implicated with an increased risk in developing TRALI in transfused patients...
  87. ncbi The metabolic effects of fresh versus old stored blood in the priming of cardiopulmonary bypass solution for pediatric patients
    Ilan Keidan
    Department of Anesthesia and Intensive Care, Sheba Medical Center, Tel Aviv University, Israel
    J Thorac Cardiovasc Surg 127:949-52. 2004
    ..The purpose of the present study was to evaluate the metabolic effects of fresh (< or =5 days) versus old (>5 days) stored packed red blood cells added to the priming solutions of pediatric patients undergoing cardiac surgery...
  88. ncbi Transfusions in the less severely injured: does age of transfused blood affect outcomes?
    Jordan A Weinberg
    Center for Injury Sciences, Section of Trauma, Burns, and Surgical Critical Care, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Trauma 65:794-8. 2008
    ..The purpose of this study was to evaluate the association between the age of stored blood and the morbidity and mortality in a mild to moderately injured patient cohort...
  89. ncbi Clinical implications of red blood cell and platelet storage lesions: an overview
    B G Solheim
    Institute of Immunology, Rikshospitalet University Hospital, NO 0027 Oslo, Norway
    Transfus Apher Sci 31:185-9. 2004
    ..This overview highlights some laboratory and clinical aspects of red cell and platelet storage lesions...
  90. ncbi The effect of storage time of human red cells on intestinal microcirculatory oxygenation in a rat isovolemic exchange model
    N J Raat
    Department of Physiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Crit Care Med 33:39-45; discussion 238-9. 2005
    ..To determine whether the storage time of human leukodepleted red blood cell concentrates compromises intestinal microvascular oxygen concentration oxygen (muPo(2)) during isovolemic exchange transfusion at low hematocrit...
  91. ncbi A pilot trial evaluating the clinical effects of prolonged storage of red cells
    Paul C Hebert
    University of Ottawa Centre forTransfusion Research, Clinical Epidemiology Unit, Ottawa Hospital Research Institute, Ontario, Canada
    Anesth Analg 100:1433-8, table of contents. 2005
    ..05). A large clinical trial comparing red cell storage times is feasible and warranted given the limited available evidence...
  92. ncbi [Cord blood banking: public versus private banks--facts to ponder and consider]
    J H Dalle
    Unité protégée A, Clinique de Pediatrie, Hopital Jeanne de Flandre, CHU de Lille, 59037 Lille cedex France
    Arch Pediatr 12:298-304. 2005
    ..In this work, we review available scientific data, ethical considerations and laws that can contribute to an informed reflection...
  93. ncbi Effects of fresh versus old stored blood in the priming solution on whole blood lactate levels during paediatric cardiac surgery
    Torsten H Schroeder
    Department of Anesthesiology and Transfusion Medicine, Tuebingen University Hospital, Tuebingen, Germany
    Perfusion 20:17-9. 2005
    ..43+0.36 versus 3.46+/-0.63, p=0.0006). Our results suggest that the higher lactate levels found after the initiation of CPB should be used with caution when assessing tissue hypoxia and predicting outcome...
  94. ncbi Increased rate of infection associated with transfusion of old blood after severe injury
    Patrick J Offner
    Trauma Service, St Anthony Central Hospital, 4231 W 16th Ave, Denver, CO 80204, USA
    Arch Surg 137:711-6; discussion 716-7. 2002
    ..We hypothesized that transfusion of old blood increases infection risk in severely injured patients...
  95. ncbi An update on solutions for red cell storage
    J R Hess
    Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 20817, USA
    Vox Sang 91:13-9. 2006
    ..Improved scientific understanding of the red cell storage lesion has shown a way to make even better storage solutions, which maintain red cell metabolism and reduce membrane loss...
  96. ncbi Fresh blood for everyone? Balancing availability and quality of stored RBCs
    W Dzik
    Blood Transfusion Service, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Transfus Med 18:260-5. 2008
    ..Given the fundamental importance of a safe and adequate blood supply to national healthcare, the question of the proper storage age for blood should be studied using a prospective study design...
  97. ncbi Evaluation and analysis of exposure levels of di(2-ethylhexyl) phthalate from blood bags
    Koichi Inoue
    Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Hoshi University, 2 4 41 Ebara, Tokyo 142 8501, Japan
    Clin Chim Acta 358:159-66. 2005
    ..We evaluated DEHP and mono(2-ethylhexyl) phthalate (MEHP) levels, migration patterns, and metabolism in blood products for the detailed assessment of exposure to DEHP...
  98. ncbi Effect of cryopreservation on measurement of cytomegalovirus-specific cellular immune responses in HIV-infected patients
    A Weinberg
    University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Acquir Immune Defic Syndr 25:109-14. 2000
    ..These data indicate that cryopreserved cells are suitable for longitudinal studies of the CMV-specific immune response in HIV-infected patients and uninfected controls...
  99. ncbi Salvaging of liquid-preserved O-positive and O-negative red blood cells by rejuvenation and freezing
    Gina Ragno
    NBRL, Boston, MA 02118, USA
    Transfus Apher Sci 35:137-43. 2006
    ..This study was done to determine if universal donor O-positive and O-negative RBC subjected to various methods of transportation could subsequently be rejuvenated and frozen to be used for inventory control with satisfactory results...
  100. ncbi Galactosylation does not prevent the rapid clearance of long-term, 4 degrees C-stored platelets
    Hans H Wandall
    ZymeQuest, Beverly, MA, USA
    Blood 111:3249-56. 2008
    ..We conclude that different mechanisms of clearance may exist for short- and long-term cold-stored platelets...
  101. ncbi Propionibacterium acnes lacks the capability to proliferate in platelet concentrates
    M Störmer
    Institut fur Laboratoriums und Transfusionsmedizin, Herz und Diabeteszentrum Nordrhein Westfalen, Universitatsklinik der Ruhr Universitat Bochum, Bad Oeynhausen, Germany
    Vox Sang 94:193-201. 2008
    ..Furthermore, we assessed the bacterial proliferation of Propionibacterium species seeded into PCs to clarify their significance for platelet bacteria screening...

Research Grants27

  1. VIRUS PHOTOINACTIVATION--DIMETHYLMETHYLENE BLUE IN RBC
    Stephen Wagner; Fiscal Year: 2004
    ..abstract_text> ..
  2. NOVEL APPROACHES TO IMPROVE AND EXTEND PLATELET STORAGE
    Sherrill Slichter; Fiscal Year: 2001
    ....
  3. Automated high-throughput detection anti-HLA antibodies
    John Roback; Fiscal Year: 2006
    ..This application proposes to develop a test that could be used to screen blood donors for these antibodies, thus preventing TRALI and improving patient outcomes. [unreadable] [unreadable] [unreadable]..
  4. Allogeneic BMT and adoptive antiviral immunotherapy
    John Roback; Fiscal Year: 2005
    ..Furthermore, these investigations will provide an improved understanding of the defects that render allogeneic HPCT recipients susceptible to lethal infections. ..
  5. NOVEL DEVICES FOR RAPID BLOOD COMPATIBILITY TESTING
    John Roback; Fiscal Year: 2004
    ..The results of the multi-center trial (to be completed during Phase Ill) will lead to an FDA 510(k) application. ..
  6. Rapid quantitation of residual WBCs in filtered blood
    John Roback; Fiscal Year: 2004
    ....
  7. Vaccine-enhanced DLI to prevent cancer recurrence after stem cell transplantation
    John Roback; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  8. CHEMOKINES/CYTOKINES AND RECEPTORS IN STEM CELL HOMING
    Hal Broxmeyer; Fiscal Year: 2005
    ..These studies should clarity the relevance of SDF-1 and CXCR4 for homing/engraftment and mobilization of primary stem/progenitor cells. ..
  9. Lyso-PCs activate PMNs and endothelium via PKC
    CHRISTOPHER SILLIMAN; Fiscal Year: 2006
    ..Completion of these specific aims will likely result in targets for in vitro, and possibly clinical, intervention to develop methods to inhibit or to attenuate the effects of these lipids and ultimately make transfusion safer. ..
  10. Effects of Nitric Oxide in Sickle Cell Blood
    DANIEL KIM SHAPIRO; Fiscal Year: 2006
    ..Our studies will help us understand important issues related to NO's role in sickle cell disease and in the general population. ..
  11. Endothelial Dysfunction Due to HIV-1 Protease Inhibitors
    Mitchell Goldman; Fiscal Year: 2006
    ..abstract_text> ..
  12. REGULATORY MECHANISMS OF GROWTH-PLATE CHONDROCYTES
    Robert Olney; Fiscal Year: 2002
    ..Conversely, by identifying the important regulators of the human growth-plate, we will provide clues to direct the search for the genes responsible for some of the osteochondrodysplasias. ..
  13. Erythrocyte Nitrosothiol Flux and Vasoregulation in Lung
    Allan Doctor; Fiscal Year: 2008
    ..The candidate's long-term goal is to define the mechanism of NO traffic between regional vascular beds via the erythrocyte, and its role in the evolution of multiple organ failure in severe inflammatory states. ..
  14. Pediatric Clinical Research Scholar Program - Washington
    Naomi Luban; Fiscal Year: 2007
    ..abstract_text> ..
  15. Reconstitution of Protective CMV Immunity and Immune Regulation After HAART
    Adriana Weinberg; Fiscal Year: 2008
    ..These analyses will define the role of TREG in the inadequate CMV immune reconstitution of HAART recipients. [unreadable] [unreadable] [unreadable] [unreadable]..
  16. Inhibin/Activin Family in Human Cranifocial Development
    Geralyn Messerlian; Fiscal Year: 2003
    ..abstract_text> ..
  17. Defining the Clinical Significance of HbA1c Prior to the Onset of Diabetes
    Elizabeth Selvin; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  18. Biochemical Stabilization for Freeze Dried Platelets
    Christopher Wagner; Fiscal Year: 2003
    ..abstract_text> ..
  19. 6th International Feline Retrovirus Research Symposium
    JANET YAMAMOTO; Fiscal Year: 2002
    ..By exposure to state-of-the-art speakers in HIV, SlV, and HTLV, we hope to update and identify new directions in FIV and FeLV research. ..
  20. Immune Mechanisms of Red Cell Alloimmunization
    SALLY CAMPBELL LEE; Fiscal Year: 2005
    ....
  21. Erythrocyte Complement Receptor 1 in Transfusion/Malaria
    Karina Yazdanbakhsh; Fiscal Year: 2005
    ....
  22. RESEARCH TRAINING IN TRANSFUSION MEDICINE
    Jeffrey McCullough; Fiscal Year: 2003
    ..abstract_text> ..
  23. Assessing Circulating Progenitor Cells in Heart Disease
    Thomas Povsic; Fiscal Year: 2007
    ..This study will look at two methods of measuring these stem cells in the blood of heart patients. These methods may someday be used to predict who will or will not develop heart disease or other complications. ..
  24. Conference-Safeguarding Adult/Pediatric Stem Cell Donors
    Edward Snyder; Fiscal Year: 2004
    ..This Symposium would address the need for such Standards and stimulate the process. AIM 3 will be to publish a summary of the Symposium in a nationally recognized Journal. ..
  25. Folate Polymorphisms, Dietary Folate and Prostate Cancer
    Victoria Stevens; Fiscal Year: 2005
    ..The results of this study are expected to indicate the importance of folate for prostate cancer and whether changing folate consumption can modify the risk associated with genetic variants in the pathway for folate metabolism. ..
  26. Symposium on Emerging Cardiac Cellular Therapies
    Edward Snyder; Fiscal Year: 2005
    ..abstract_text> ..