animal physical conditioning

Summary

Summary: Physical conditioning of domestic, laboratory, and zoo animals. Includes exercising of animals.

Top Publications

  1. ncbi Role of AMP-activated protein kinase in exercise capacity, whole body glucose homeostasis, and glucose transport in skeletal muscle -insight from analysis of a transgenic mouse model-
    Nobuharu Fujii
    Research Division, Joslin Diabetes Center, and the Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, One Joslin Place, Boston, MA 02215, USA
    Diabetes Res Clin Pract 77:S92-8. 2007
  2. ncbi Muscle-specific expression of PPARgamma coactivator-1alpha improves exercise performance and increases peak oxygen uptake
    Jennifer A Calvo
    Novartis Institutes for BioMedical Research, 100 Technology Square, Cambridge, MA 02139, USA
    J Appl Physiol (1985) 104:1304-12. 2008
  3. ncbi Exhaustive exercise causes an anti-inflammatory effect in skeletal muscle and a pro-inflammatory effect in adipose tissue in rats
    José C Rosa Neto
    Department of Physiology of Nutrition, Federal University of Sao Paulo, Sao Paulo, SP CEP 04023 060, Brazil
    Eur J Appl Physiol 106:697-704. 2009
  4. ncbi Exercise and the immune system: regulation, integration, and adaptation
    B K Pedersen
    Department of Infectious Diseases and Copenhagen Muscle Research Centre, University of Copenhagen, Copenhagen, Denmark
    Physiol Rev 80:1055-81. 2000
  5. ncbi Cardiovascular risk factors emerge after artificial selection for low aerobic capacity
    Ulrik Wisløff
    Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Olav Kyrres gt 3, 7489 Trondheim, Norway
    Science 307:418-20. 2005
  6. ncbi Skeletal muscle adaptation to exercise training: AMP-activated protein kinase mediates muscle fiber type shift
    Katja S C Röckl
    Research Division, Joslin Diabetes Center and Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes 56:2062-9. 2007
  7. ncbi Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease
    Paul A Adlard
    Institute for Brain Aging and Dementia, University of California, Irvine, Irvine, California 92697 4540, USA
    J Neurosci 25:4217-21. 2005
  8. ncbi AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism
    Barbara B Kahn
    Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Cell Metab 1:15-25. 2005
  9. pmc Regulation of muscle fiber type and running endurance by PPARdelta
    Yong Xu Wang
    Gene Expression Laboratory, Salk Institute, La Jolla, California, USA
    PLoS Biol 2:e294. 2004
  10. ncbi Exercise induces behavioral recovery and attenuates neurochemical deficits in rodent models of Parkinson's disease
    J L Tillerson
    Institute for Neuroscience, University of Texas at Austin, Austin, TX, 78712, USA
    Neuroscience 119:899-911. 2003

Detail Information

Publications268 found, 100 shown here

  1. ncbi Role of AMP-activated protein kinase in exercise capacity, whole body glucose homeostasis, and glucose transport in skeletal muscle -insight from analysis of a transgenic mouse model-
    Nobuharu Fujii
    Research Division, Joslin Diabetes Center, and the Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, One Joslin Place, Boston, MA 02215, USA
    Diabetes Res Clin Pract 77:S92-8. 2007
    ..However, contraction- or hyperosmolarity-induced glucose transport was nearly normal. These results suggest that AMPK alpha2 activation is essential for some, but not all insulin-independent glucose transport...
  2. ncbi Muscle-specific expression of PPARgamma coactivator-1alpha improves exercise performance and increases peak oxygen uptake
    Jennifer A Calvo
    Novartis Institutes for BioMedical Research, 100 Technology Square, Cambridge, MA 02139, USA
    J Appl Physiol (1985) 104:1304-12. 2008
    ..Thus this study demonstrates that upregulation of PGC-1alpha in muscle in vivo is sufficient to greatly improve exercise performance under various exercise paradigms as well as increase peak oxygen uptake...
  3. ncbi Exhaustive exercise causes an anti-inflammatory effect in skeletal muscle and a pro-inflammatory effect in adipose tissue in rats
    José C Rosa Neto
    Department of Physiology of Nutrition, Federal University of Sao Paulo, Sao Paulo, SP CEP 04023 060, Brazil
    Eur J Appl Physiol 106:697-704. 2009
    ....
  4. ncbi Exercise and the immune system: regulation, integration, and adaptation
    B K Pedersen
    Department of Infectious Diseases and Copenhagen Muscle Research Centre, University of Copenhagen, Copenhagen, Denmark
    Physiol Rev 80:1055-81. 2000
    ..Accordingly, drawing on the experimental, clinical, and epidemiological literature, we address the interactions between exercise and infectious diseases as well as exercise and neoplasia within the context of both aging and nutrition...
  5. ncbi Cardiovascular risk factors emerge after artificial selection for low aerobic capacity
    Ulrik Wisløff
    Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Olav Kyrres gt 3, 7489 Trondheim, Norway
    Science 307:418-20. 2005
    ..Impairment of mitochondrial function may link reduced fitness to cardiovascular and metabolic disease...
  6. ncbi Skeletal muscle adaptation to exercise training: AMP-activated protein kinase mediates muscle fiber type shift
    Katja S C Röckl
    Research Division, Joslin Diabetes Center and Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes 56:2062-9. 2007
    ..AMPK is not necessary for exercise training-induced increases in mitochondrial markers, but it is essential for fiber type IIb to IIa/x transformation and increases in hexokinase II protein...
  7. ncbi Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease
    Paul A Adlard
    Institute for Brain Aging and Dementia, University of California, Irvine, Irvine, California 92697 4540, USA
    J Neurosci 25:4217-21. 2005
    ..In support of existing epidemiological studies, this investigation demonstrates that exercise is a simple behavioral intervention sufficient to inhibit the normal progression of AD-like neuropathology in the TgCRND8 mouse model...
  8. ncbi AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism
    Barbara B Kahn
    Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Cell Metab 1:15-25. 2005
    ..Through signaling, metabolic, and gene expression effects, AMPK enhances insulin sensitivity and fosters a metabolic milieu that may reduce the risk for obesity and type 2 diabetes...
  9. pmc Regulation of muscle fiber type and running endurance by PPARdelta
    Yong Xu Wang
    Gene Expression Laboratory, Salk Institute, La Jolla, California, USA
    PLoS Biol 2:e294. 2004
    ..These results demonstrate that complex physiologic properties such as fatigue, endurance, and running capacity can be molecularly analyzed and manipulated...
  10. ncbi Exercise induces behavioral recovery and attenuates neurochemical deficits in rodent models of Parkinson's disease
    J L Tillerson
    Institute for Neuroscience, University of Texas at Austin, Austin, TX, 78712, USA
    Neuroscience 119:899-911. 2003
    ..These results demonstrate that exercise following nigrostriatal damage ameliorates related motor symptoms and neurochemical deficits in rodent models of PD...
  11. ncbi The effects of forced exercise on hippocampal plasticity in the rat: A comparison of LTP, spatial- and non-spatial learning
    Robert Ohle
    Department of Physiology, School of Medicine, University of Dublin, Trinity College, Dublin 2, Ireland
    Behav Brain Res 176:362-6. 2007
    ..Spatial learning in the Morris watermaze was unaffected by exercise. These changes were associated with an increase in expression of brain-derived neurotrophic factor in the dentate gyrus...
  12. ncbi Habitual low-intensity exercise does not protect against myocardial dysfunction after ischemia in rats
    Joseph W Starnes
    Department of Kinesiology and Health Education, Cardiac Metabolism Laboratory, University of Texas, Austin, Texas 78712, USA
    Eur J Cardiovasc Prev Rehabil 12:169-74. 2005
    ..Thus, the purpose of this study is to determine whether low-intensity exercise provides self-protection to the heart against I-R injury...
  13. ncbi Moderate vs. high exercise intensity: differential effects on aerobic fitness, cardiomyocyte contractility, and endothelial function
    Ole J Kemi
    Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
    Cardiovasc Res 67:161-72. 2005
    ..We therefore assessed relative effectiveness of 10-week HIGH versus moderate (MOD) exercise intensity on integrative and cellular functions...
  14. ncbi Intensity-controlled treadmill running in mice: cardiac and skeletal muscle hypertrophy
    Ole Johan Kemi
    Department of Physiology and Biomedical Engineering, Norwegian University of Science and Technology, N 7489 Trondheim, Norway
    J Appl Physiol 93:1301-9. 2002
    ..Thus the model mimics human responses to exercise and can be used in future studies of molecular mechanisms underlying these adaptations...
  15. ncbi Mechanisms of stroke protection by physical activity
    Matthias Endres
    Klinik und Poliklinik fur Neurologie, Charite, Humboldt Universitat zu Berlin, Schumannstrasse 20 21, D 10117 Berlin, Germany
    Ann Neurol 54:582-90. 2003
    ..Our results suggest that physical activity not only decreases stroke risk, but also provides a prophylactic treatment strategy for increasing blood flow and reducing brain injury during cerebral ischemia...
  16. pmc Voluntary exercise produces antidepressant and anxiolytic behavioral effects in mice
    Catharine H Duman
    Division of Molecular Psychiatry, Abraham Ribicoff Research Facilities, Department of Psychiatry and Pharmacology, Yale University School of Medicine, New Haven, CT 06508, USA
    Brain Res 1199:148-58. 2008
    ..In summary, chronic wheel-running exercise in mice results in antidepressant-like behavioral changes that may involve a BDNF related mechanism similar to that hypothesized for antidepressant drug treatment...
  17. ncbi VEGF gradients, receptor activation, and sprout guidance in resting and exercising skeletal muscle
    Feilim Mac Gabhann
    Dept of Biomedical Engineering, Johns Hopkins Univ School of Medicine, 720 Rutland Ave, Baltimore, MD 2120, USA
    J Appl Physiol (1985) 102:722-34. 2007
    ..e., perpendicular to the muscle fibers) than in the longitudinal direction. This may explain observed perpendicular anastomoses in skeletal muscle...
  18. ncbi Exercise restores endothelial function independently of weight loss or hyperglycaemic status in db/db mice
    F Moien-Afshari
    Department of Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada
    Diabetologia 51:1327-37. 2008
    ....
  19. ncbi PGC-1alpha mediates exercise-induced skeletal muscle VEGF expression in mice
    Lotte Leick
    Department of Biology, University of Copenhagen, Universitetsparken 13, 2100 Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 297:E92-103. 2009
    ..Furthermore, the findings suggest an AMPK-mediated regulation of VEGF expression through PGC-1alpha...
  20. ncbi Effects of high intensity exercise training on cardiovascular function, oxygen uptake, internal oxygen transport and osmotic balance in chinook salmon (Oncorhynchus tshawytscha) during critical speed swimming
    P E Gallaugher
    Continuing Studies in Science, Simon Fraser University, Burnaby, BC, Canada
    J Exp Biol 204:2861-72. 2001
    ..99) among temperate fish species, it is likely that CaO2 and Qmax are principal loci for cardiorespiratory evolutionary adaptation but not for intraspecific cardiorepiratory plasticity as revealed by high intensity exercise training...
  21. pmc Aerobic interval training enhances cardiomyocyte contractility and Ca2+ cycling by phosphorylation of CaMKII and Thr-17 of phospholamban
    Ole J Kemi
    Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    J Mol Cell Cardiol 43:354-61. 2007
    ..These observations indicate that calcium/calmodulin-dependent kinase IIdelta contributes significantly to the functional adaptation of the cardiomyocyte to regular exercise training...
  22. ncbi Long-term locomotor training up-regulates TrkB(FL) receptor-like proteins, brain-derived neurotrophic factor, and neurotrophin 4 with different topographies of expression in oligodendroglia and neurons in the spinal cord
    Malgorzata Skup
    Department of Neurophysiology, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur St 02 093 Warsaw, Poland
    Exp Neurol 176:289-307. 2002
    ..Oligodendrocytes of the spinal gray matter were particularly responsive to exercise, pointing to their involvement in activity-driven cross talk between neurons and glia...
  23. pmc Acute physical exercise reverses S-nitrosation of the insulin receptor, insulin receptor substrate 1 and protein kinase B/Akt in diet-induced obese Wistar rats
    Jose R Pauli
    Departamento de Clinica Medica, FCM UNICAMP, Universidade Estadual de Campinas, Campinas, SP, Brasil
    J Physiol 586:659-71. 2008
    ..These results provide new insights into the mechanism by which exercise restores insulin sensitivity...
  24. ncbi Exercise training changes autonomic cardiovascular balance in mice
    K De Angelis
    Hypertension Unit, Heart Institute University of São Paulo, Medical School, 05403 000 Sao Paulo, Brazil
    J Appl Physiol 96:2174-8. 2004
    ..These changes are likely related to an increased vagal and decreased sympathetic tone, similar to the exercise response observed in humans...
  25. ncbi Psychological stress increases histone H3 phosphorylation in adult dentate gyrus granule neurons: involvement in a glucocorticoid receptor-dependent behavioural response
    Alicia Bilang-Bleuel
    Max Planck Institute of Psychiatry, Section of Neuropsychopharmacology, Munich, Germany
    Eur J Neurosci 22:1691-700. 2005
    ....
  26. ncbi Increased astrocyte proliferation in rats after running exercise
    Jie Li
    Department of Neurological Surgery, Wayne State University School of Medicine, Canfield, Detroit, MI 48201, USA
    Neurosci Lett 386:160-4. 2005
    ..Strengthening of this unit by exercise may protect blood-brain-barrier function following brain injury, such as that occurring after stroke...
  27. ncbi Tenocyte responses to mechanical loading in vivo: a role for local insulin-like growth factor 1 signaling in early tendinosis in rats
    Alexander Scott
    University of British Columbia, Vancouver, British Columbia, Canada
    Arthritis Rheum 56:871-81. 2007
    ..To investigate tenocyte regulatory events during the development of overuse supraspinatus tendinosis in rats...
  28. ncbi Intact neurogenesis is required for benefits of exercise on spatial memory but not motor performance or contextual fear conditioning in C57BL/6J mice
    P J Clark
    Department of Psychology, The Beckman Institute, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Neuroscience 155:1048-58. 2008
    ..Results support the hypothesis that intact exercise-induced hippocampal neurogenesis is required for improved spatial memory, but not motor performance or contextual fear in C57BL/6J mice...
  29. ncbi Free radicals generated by contracting muscle: by-products of metabolism or key regulators of muscle function?
    Malcolm J Jackson
    Division of Metabolic and Cellular Medicine, School of Clinical Sciences, University of Liverpool, Liverpool L69 3GA, UK
    Free Radic Biol Med 44:132-41. 2008
    ....
  30. ncbi Exercise-induced behavioral recovery and neuroplasticity in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse basal ganglia
    Beth E Fisher
    Department of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, California 90033, USA
    J Neurosci Res 77:378-90. 2004
    ..Our data demonstrates that exercise promotes behavioral recovery in the injured brain by modulating genes and proteins important to basal ganglia function...
  31. ncbi Protective effects of treadmill training on infarction in rats
    R Y Wang
    Faculty of Physical Therapy, National Yang Ming University, 155, Section 2, Li Nong Street, Shih Pai, Taipei, Taiwan
    Brain Res 922:140-3. 2001
    ..01). The present study provides evidence that treadmill training reduces ischemic brain damage in an animal model of cerebral ischemia...
  32. ncbi Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis
    Jason Brown
    Department of Neurology, University of Regensburg, 93053 Regensburg, Germany
    Eur J Neurosci 17:2042-6. 2003
    ..The discrepancy between the olfactory bulb and the dentate gyrus suggests that these living conditions trigger locally through an as yet unidentified mechanism specific to neurogenic signals in the dentate gyrus...
  33. ncbi Physical activity elicits sustained activation of the cyclic AMP response element-binding protein and mitogen-activated protein kinase in the rat hippocampus
    H Shen
    Institute for Brain Aging and Dementia, University of California, Irvine, CA 92697-4540, USA
    Neuroscience 107:219-29. 2001
    ....
  34. ncbi Locomotor exercise alters expression of pro-brain-derived neurotrophic factor, brain-derived neurotrophic factor and its receptor TrkB in the spinal cord of adult rats
    Matylda Macias
    Department of Neurophysiology, Nencki Institute of Experimental Biology, 3 Pasteur Street, 02 093 Warsaw, Poland
    Eur J Neurosci 25:2425-44. 2007
    ....
  35. ncbi Genetic expression profiles during physiological and pathological cardiac hypertrophy and heart failure in rats
    Sek Won Kong
    Cardiovascular Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Physiol Genomics 21:34-42. 2005
    ..In addition, there were significant changes in glucose/insulin signaling, protein biosynthesis, and epidermal growth factor signaling during physiological hypertrophy but not during pathological hypertrophy...
  36. ncbi The exercise-induced expression of BDNF within the hippocampus varies across life-span
    Paul A Adlard
    Institute for Brain Aging and Dementia, University of California, 1125 Gillespie N R F, Irvine, CA 92697 4540, USA
    Neurobiol Aging 26:511-20. 2005
    ..BDNF protein induction may, therefore, not be directly correlated with significant mRNA changes. Exercise may represent a therapeutic tool for disorders which involve a decrease in BDNF...
  37. ncbi Exercise primes a molecular memory for brain-derived neurotrophic factor protein induction in the rat hippocampus
    N C Berchtold
    Institute for Brain Aging and Dementia, 1226 Gillespie Neuroscience Facility, University of California, Irvine, CA 92697 4540, USA
    Neuroscience 133:853-61. 2005
    ..These findings are clinically important because they provide guidelines for optimizing the design of exercise and rehabilitation programs, in order to promote hippocampal function...
  38. ncbi Exercise attenuates diabetes-induced ultrastructural changes in rat cardiac tissue
    Yvonne M Searls
    Departments of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS, USA
    Med Sci Sports Exerc 36:1863-70. 2004
    ..This study sought to explore the effects of endurance exercise on the ultrastructural changes seen in diabetic cardiomyopathy...
  39. ncbi Exercise training improves muscle insulin resistance but not insulin receptor signaling in obese Zucker rats
    Christine Y Christ
    Department of Physiology, University of Texas Health Sciences Center, San Antonio, Texas 78712, USA
    J Appl Physiol 92:736-44. 2002
    ....
  40. ncbi Exercise, antioxidants, and HSP72: protection against myocardial ischemia/reperfusion
    Karyn L Hamilton
    Department of Exercise and Sport Science, Center for Exercise Science, University of Florida, Gainesville, FL 32611, USA
    Free Radic Biol Med 34:800-9. 2003
    ....
  41. ncbi Development and characterization of an overtraining animal model
    Rodrigo Hohl
    Laboratory of Exercise Biochemistry LABEX, Biochemistry Department, Biology Institute, State University of Campinas UNICAMP, Campinas, Brazil
    Med Sci Sports Exerc 41:1155-63. 2009
    ..Development of an endurance training-overtraining protocol for Wistar rats that includes increased workload and is characterized by analyses of performance and biomarkers...
  42. ncbi Distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampus
    Chunmei Zhao
    Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 26:3-11. 2006
    ..Our study reveals the key morphological transitions of newborn granule neurons during their course of maturation...
  43. ncbi Exercise-induced promotion of hippocampal cell proliferation requires beta-endorphin
    M Koehl
    Centre de Recherche INSERM U862, Physiopathologie de la Plasticité Neuronale, 146 rue Leo Saignat, 33077 Bordeaux Cedex, France
    FASEB J 22:2253-62. 2008
    ..We conclude that beta-endorphin released during running is a key factor for exercise-induced cell proliferation and that a homeostatic balance may regulate the final number of new neurons...
  44. ncbi Treadmill training ameliorates dopamine loss but not behavioral deficits in hemi-parkinsonian rats
    Nadine P Poulton
    Biomedical Sciences, WCVM, University of Saskatchewan, 52 Campus Drive, Saskatoon, SK, Canada S7N 5B4
    Exp Neurol 193:181-97. 2005
    ..We conclude that treadmill training does not ameliorate locomotor deficits in the 6-OHDA model of Parkinson's disease, even though this same training results in attenuation of dopamine loss in the striatum...
  45. pmc Functional recovery in rats with chronic spinal cord injuries after exposure to an enriched environment
    Florence R Fischer
    Wayne State University School of Medicine, 8137 Scott Hall, 540 E Canfield Avenue, Detroit, MI 48201, USA
    J Spinal Cord Med 30:147-55. 2007
    ..The objective of this study was to determine the effect of environmental enrichment on the sensorimotor function of rats with chronic spinal cord injuries...
  46. ncbi Temporal thrombospondin-1 mRNA response in skeletal muscle exposed to acute and chronic exercise
    I Mark Olfert
    Division of Physiology, Department of Medicine, University of California San Diego, La Jolla, CA 92093 0623, USA
    Growth Factors 24:253-9. 2006
    ....
  47. ncbi Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1
    Keith Baar
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    FASEB J 16:1879-86. 2002
    ..These findings suggest that increases in PGC-1, NRF-1, and NRF-2 represent key regulatory components of the stimulation of mitochondrial biogenesis by exercise and that PGC-1 mediates the coordinated increases in GLUT4 and mitochondria...
  48. ncbi Inhibitory effects of voluntary running wheel exercise on UVB-induced skin carcinogenesis in SKH-1 mice
    Laura Michna
    Joint Graduate Program in Toxicology, The State University of New Jersey, Piscataway, NJ 08854, USA
    Carcinogenesis 27:2108-15. 2006
    ..The effects described here indicate that voluntary running wheel exercise inhibits UVB-induced skin tumorigenesis and may also inhibit tumor growth...
  49. ncbi VEGF is necessary for exercise-induced adult hippocampal neurogenesis
    Klaus Fabel
    Department of Neurosurgery, Mail Code 5487, MSLS P309, 1201 Welch Rd, Stanford University, Stanford, CA 94305 5487, USA
    Eur J Neurosci 18:2803-12. 2003
    ....
  50. ncbi Insulin-like growth factor I interfaces with brain-derived neurotrophic factor-mediated synaptic plasticity to modulate aspects of exercise-induced cognitive function
    Q Ding
    Department of Physiological Science, UCLA, 621 Charles E Young Drive, Los Angeles, CA 90095, USA
    Neuroscience 140:823-33. 2006
    ..Our results illustrate a possible mechanism by which insulin-like growth factor-I interfaces with the brain-derived neurotrophic factor system to mediate exercise-induced synaptic and cognitive plasticity...
  51. ncbi Cardiac and skeletal muscle adaptations to voluntary wheel running in the mouse
    D L Allen
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder 80309 0347, USA
    J Appl Physiol (1985) 90:1900-8. 2001
    ..All results are relative to age-matched mice housed without access to running wheels. Together these data demonstrate that voluntary exercise in mice results in cardiac and skeletal muscle adaptations consistent with endurance exercise...
  52. ncbi Effects of sprint exercise on oxidative stress in skeletal muscle and liver
    Berkant Muammer Kayatekin
    Dokuz Eylul University Medical School, Department of Physiology, 35340 Balcova, Izmir, Turkey
    Eur J Appl Physiol 87:141-4. 2002
    ..In conclusion, acute sprint exercise in mice resulted in an increase in TBARS levels in skeletal muscle; no change was observed in the liver. Antioxidant enzyme activities remained unaffected by acute sprint exercise in these tissues...
  53. ncbi Exercise restores levels of neurotrophins and synaptic plasticity following spinal cord injury
    Zhe Ying
    Department of Physiological Science, UCLA, Los Angeles, CA 90095 1527, USA Division of Neurosurgery, UCLA Brain Injury Research Center, Los Angeles, CA 90095 1527, USA
    Exp Neurol 193:411-9. 2005
    ..These results are consistent with the concept that synaptic pathways under the regulatory role of BDNF induced by exercise can play a role in facilitating recovery of locomotion following spinal cord injury...
  54. ncbi Exercise preconditioning upregulates cerebral integrins and enhances cerebrovascular integrity in ischemic rats
    Y H Ding
    Department of Neurological Surgery, Wayne State University School of Medicine, Detroit, MI, USA
    Acta Neuropathol 112:74-84. 2006
    ..The study suggests that upregulation of integrins during exercise enhances neurovascular integrity after stroke. The changes in integrins might be altered by TNF-alpha...
  55. ncbi Functional, structural and molecular plasticity of mammalian skeletal muscle in response to exercise stimuli
    Martin Fluck
    Unit for Functional Anatomy, Department of Anatomy, University of Berne, Baltzerstrasse 2, Switzerland
    J Exp Biol 209:2239-48. 2006
    ..The identification of the basic relationships underlying the malleability of muscle tissue is likely to be of relevance for our understanding of compensatory processes in other tissues, species and organisms...
  56. ncbi Role of exercise training in cardiovascular autonomic dysfunction and mortality in diabetic ovariectomized rats
    Silvia B C Souza
    Hypertension Unit, Heart Institute InCor, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Hypertension 50:786-91. 2007
    ....
  57. ncbi Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta
    Deborah M Muoio
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 277:26089-97. 2002
    ....
  58. ncbi Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition
    Shoshanna Vaynman
    Department of Physiological Science, UCLA, 621 Charles E Young Drive, Los Angeles, CA 90095, USA
    Eur J Neurosci 20:2580-90. 2004
    ..These findings suggest a functional role for CREB under the control of BDNF in mediating the exercise-induced enhancement in learning and memory. Our results indicate that synapsin I might also contribute to this BDNF-mediated mechanism...
  59. ncbi The combination of dietary conjugated linoleic acid and treadmill exercise lowers gain in body fat mass and enhances lean body mass in high fat-fed male Balb/C mice
    Arunabh Bhattacharya
    Department of Medicine, Division of Clinical Immunology, University of Texas Health Science Center, San Antonio 78229 3900, USA
    J Nutr 135:1124-30. 2005
    ....
  60. ncbi Interplay between brain-derived neurotrophic factor and signal transduction modulators in the regulation of the effects of exercise on synaptic-plasticity
    S Vaynman
    Department of Physiological Science, UCLA, 621 Charles E Young Drive, Los Angeles, CA 90095, USA
    Neuroscience 122:647-57. 2003
    ..Since these molecules have a well-described association to BDNF action, our results illustrate a basic mechanism through which exercise may promote synaptic-plasticity in the adult brain...
  61. pmc AMPK and PPARdelta agonists are exercise mimetics
    Vihang A Narkar
    Gene Expression Laboratory, Salk Institute, La Jolla, CA 92037, USA
    Cell 134:405-15. 2008
    ..These results demonstrate that AMPK-PPARdelta pathway can be targeted by orally active drugs to enhance training adaptation or even to increase endurance without exercise...
  62. ncbi Physical exercise prevents age-related decline in precursor cell activity in the mouse dentate gyrus
    Golo Kronenberg
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Robert Rossle Str 10, 13125 Berlin, Germany
    Neurobiol Aging 27:1505-13. 2006
    ..We propose that physical activity might contribute to successful aging by increasing the potential for neurogenesis represented by the pool of proliferating precursor cells...
  63. ncbi Selective activation of AMPK-PGC-1alpha or PKB-TSC2-mTOR signaling can explain specific adaptive responses to endurance or resistance training-like electrical muscle stimulation
    P J Atherton
    School of Life Sciences, University of Dundee, UK
    FASEB J 19:786-8. 2005
    ..We term this behavior the "AMPK-PKB switch." We hypothesize that the AMPK-PKB switch is a mechanism that partially mediates specific adaptations to endurance and resistance training, respectively...
  64. ncbi AMPK activity is diminished in tissues of IL-6 knockout mice: the effect of exercise
    Meghan Kelly
    Diabetes Unit, Section of Endocrinology, Boston Medical Center and Departments of Medicine and Physiology, Boston University School of Medicine, Boston, MA 02118, USA
    Biochem Biophys Res Commun 320:449-54. 2004
    ..They also suggest that a genetic lack of IL-6 is associated with a decrease in AMPK activity...
  65. ncbi The molecular bases of training adaptation
    Vernon G Coffey
    School of Medical Sciences, Exercise Metabolism Group, RMIT University, Melbourne, Victoria, Australia
    Sports Med 37:737-63. 2007
    ..This article highlights the effects of exercise on molecular and genetic mechanisms of training adaptation in skeletal muscle...
  66. pmc Voluntary exercise improves insulin sensitivity and adipose tissue inflammation in diet-induced obese mice
    Richard L Bradley
    Dept of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Am J Physiol Endocrinol Metab 295:E586-94. 2008
    ..These results suggest that exercise partially reduces adiposity, reverses insulin resistance and decreases adipose tissue inflammation in diet-induced obese mice, despite continued consumption of HFD...
  67. ncbi MicroRNA-1 and microRNA-133a expression are decreased during skeletal muscle hypertrophy
    John J McCarthy
    Department of Physiology, University of Kentucky Medical Center, 800 Rose St, Lexington, KY 40536 0298, USA
    J Appl Physiol (1985) 102:306-13. 2007
    ..These results are the first to report alterations in expression of muscle-specific miRNAs in adult skeletal muscle and suggest miRNAs may have a role in the adaptation to functional overload...
  68. ncbi Effects of low-intensity prolonged exercise on PGC-1 mRNA expression in rat epitrochlearis muscle
    Shin Terada
    Laboratory of Exercise Physiology, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku City, Tokyo, Japan
    Biochem Biophys Res Commun 296:350-4. 2002
    ..These results may suggest that an acute bout of low-intensity prolonged swimming exercise directly enhances the PGC-1 mRNA expression in the activated muscle during exercise, possibly through, at least in part, an AMPK-related mechanism...
  69. pmc Activation of MEF2 by muscle activity is mediated through a calcineurin-dependent pathway
    H Wu
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    EMBO J 20:6414-23. 2001
    ....
  70. ncbi Peroxisome proliferator-activated receptor delta controls muscle development and oxidative capability
    Serge Luquet
    INSERM U470, Centre de Biochimie, Parc Valrose, Universite de Nice Sophia Antipolis, 06108 Nice Cedex 2, France
    FASEB J 17:2299-301. 2003
    ..They strongly support the idea that activation of PPARdelta could be beneficial in prevention of metabolic disorders, such as obesity or type 2 diabetes...
  71. pmc Reversal of diet-induced insulin resistance with a single bout of exercise in the rat: the role of PTP1B and IRS-1 serine phosphorylation
    Eduardo R Ropelle
    Departamento de Clinica, Medica, FCM UNICAMP, Cidade Universitaria Zeferino Vaz, Campinas, Sao Paulo, Brazil, 13081 970
    J Physiol 577:997-1007. 2006
    ..Thus, acute exercise increased the insulin sensitivity during high-fat feeding in obese rats. Overall, these results provide new insights into the mechanism by which exercise restores insulin sensitivity...
  72. ncbi Physical activity and the regulation of neurogenesis in the adult and aging brain
    Klaus Fabel
    Center for Regenerative Therapies Dresden, DFG Forschungszentrum und Exzellenzcluster, Tatzberg 47 49, 01307 Dresden, Germany
    Neuromolecular Med 10:59-66. 2008
    ..This would also explain why few new neurons could be beneficial for successful aging. We here review the current stage of the knowledge how this exercise-induced regulation of neurogenesis might work...
  73. ncbi Differential effects of voluntary physical exercise on behavioral and brain-derived neurotrophic factor expression deficits in Huntington's disease transgenic mice
    T Y C Pang
    Howard Florey Institute, University of Melbourne, Parkville, Victoria 3010, Australia
    Neuroscience 141:569-84. 2006
    ..In addition, our results reveal that some aspects of hippocampal dependent memory are not entirely reliant on sustained hippocampal brain-derived neurotrophic factor expression...
  74. ncbi Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals
    Christoph Handschin
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 282:30014-21. 2007
    ..Our data demonstrate a critical role for PGC-1alpha in maintenance of normal fiber type composition and of muscle fiber integrity following exertion...
  75. ncbi Exercise training restores abnormal myocardial glucose utilization and cardiac function in diabetes
    Tom L Broderick
    Department of Physiology, Midwestern University, 19555 59th Avenue, Glendale, AZ 85308, USA
    Diabetes Metab Res Rev 21:44-50. 2005
    ..This study determined whether exercise training could prevent the depression in glucose utilization observed in the diabetic rat heart...
  76. ncbi Overexpression of the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) in skeletal muscle repatterns energy metabolism in the mouse
    Parvin Hakimi
    Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, OH 44106 4935, USA
    J Biol Chem 282:32844-55. 2007
    ..5 years ran twice as fast as 6-12-month-old control animals. We conclude that overexpression of PEPCK-C repatterns energy metabolism and leads to greater longevity...
  77. pmc Voluntary exercise-induced changes in beta2-adrenoceptor signalling in rat ventricular myocytes
    Rachel Stones
    Institute of Membrane and Systems Biology, The University of Leeds, Leeds LS2 9JT, UK
    Exp Physiol 93:1065-75. 2008
    ....
  78. ncbi Exercise improves insulin and leptin sensitivity in hypothalamus of Wistar rats
    Marcelo B S Flores
    Department of Internal Medicine, State University of Campinas UNICAMP, 13081 970 Campinas, SP, Brazil
    Diabetes 55:2554-61. 2006
    ..These findings provide support for the hypothesis that the appetite-suppressive actions of exercise may be mediated by the hypothalamus...
  79. ncbi Short and long-term motor skill learning in an accelerated rotarod training paradigm
    Manuel M Buitrago
    Department of General Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Hoppe Seyler Strasse 3, Tubingen 72076, Germany
    Neurobiol Learn Mem 81:211-6. 2004
    ..Accelerated rotarod training can be regarded a valid paradigm for motor skill learning over short (intrasession, minutes) and long time frames (intersession, days)...
  80. ncbi Can an external device prevent dorsal displacement of the soft palate during strenuous exercise?
    J B Woodie
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    Equine Vet J 37:425-9. 2005
    ..In light of recent findings that suggested the position of the larynx may influence the occurrence of DDSP, we investigated whether a noninvasive mean of affecting the position of the larynx could be effective in the management of DDSP...
  81. ncbi Effect of growth and training on muscle adaptation in Thoroughbred horses
    Seiko Yamano
    Department of Biological Sciences, Faculty of Agriculture, Yamaguchi University, Japan
    Am J Vet Res 63:1408-12. 2002
    ..To determine the effect of growth and training on metabolic properties in muscle fibers of the gluteus medius muscle in adolescent Thoroughbred horses...
  82. ncbi Alterations in oxidative gene expression in equine skeletal muscle following exercise and training
    Suzanne S Eivers
    Animal Genomics Laboratory, University College Dublin School of Agriculture, Food Science and Veterinary Medicine, Dublin, Ireland
    Physiol Genomics 40:83-93. 2010
    ..These data highlight the roles of genes responsible for the regulation of oxygen-dependent metabolism, glucose metabolism, and fatty acid utilization in equine skeletal muscle adaptation to exercise...
  83. ncbi Changes in the rat heart proteome induced by exercise training: Increased abundance of heat shock protein hsp20
    Marvin O Boluyt
    Center for Exercise Research, Division of Kinesiology, The University of Michigan, Laboratory of Molecular Kinesiology, 401 Washtenaw Avenue, Ann Arbor, MI 48109, USA
    Proteomics 6:3154-69. 2006
    ..Thus, exercise training alters the cardiac proteome of the rat heart; the changes include a marked increase in the expression of hsp20...
  84. ncbi Exercise training alters the molecular response to myocardial infarction
    Sarit Freimann
    Neufeld Cardiac Research Institute, Tel Aviv University, Ramat Aviv, Israel
    Med Sci Sports Exerc 41:757-65. 2009
    ..The purpose of the current study was to identify temporal changes in the molecular response to myocardial infraction of prior exercise trained rats during the acute, the subacute, and the chronic phases postinfarction...
  85. ncbi cDNA Cloning and mRNA analysis of PGC-1 in epitrochlearis muscle in swimming-exercised rats
    M Goto
    Molecular Medicine Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Company, Ltd, 21 Miyukigaoka, Tsukuba, Ibaraki, 305 8585, Japan
    Biochem Biophys Res Commun 274:350-4. 2000
    ..These results demonstrate that expression of the PGC-1 gene in Epi muscle is induced not only by cold exposure but also by prolonged low-intensity physical exercise...
  86. ncbi Analysis of peripheral blood mononuclear cells gene expression in endurance horses by cDNA-AFLP technique
    Katia Cappelli
    Centro di Studio del Cavallo Sportivo, Facolta di Medicina Veterinaria, University of Perugia, Via San Costanzo 4, 06126 Perugia, Italy
    Res Vet Sci 82:335-43. 2007
    ..caballus heat shock protein 90 (Hsp90). The expression pattern of these genes was verified in other endurance horses under stressing conditions, strengthening the hypothesis of their real involvement in exercise stress-induced response...
  87. ncbi Effects of exercise on Pavlovian fear conditioning
    David E Baruch
    Department of Psychology, University of Wisconsin, Milwaukee, WI 53201, USA
    Behav Neurosci 118:1123-7. 2004
    ..The enhancement of contextual fear conditioning provides further evidence that exercise alters hippocampal function and learning...
  88. ncbi Effects of exercise training on pathological cardiac hypertrophy related gene expression and apoptosis
    Young I Lee
    Exercise Biochemistry Laboratory, Korea National Sport University, 88 15 Oryun dong, 138 763, Songpa Gu, Seoul, Korea
    Eur J Appl Physiol 97:216-24. 2006
    ....
  89. ncbi Influence of voluntary exercise on hypothalamic norepinephrine
    G W Lambert
    Institute of Physiology and Pharmacology, Department of Physiology, Goteborg University, 41390 Goteborg, Sweden
    J Appl Physiol (1985) 85:962-6. 1998
    ....
  90. ncbi Hypothalamus, hypertension, and exercise
    J M Kramer
    Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Brain Res Bull 53:77-85. 2000
    ..These findings describe a potential mechanism by which chronic exercise lowers blood pressure in the hypertensive individual...
  91. ncbi Heavy load exercise induced dysfunction of immunity and neuroendocrine responses in rats
    Chen Peijie
    Department of Sports Medicine, Shanghai Institute of Physical Education, Shanghai 200438, China
    Life Sci 72:2255-62. 2003
    ..These data suggest that 6-week heavy load training induces the dysfunction of immunity and neuroendocrine responses, which might be one of the underlying mechanisms of immune dysfunction in overtraining...
  92. ncbi Effect of high intensity training on anaerobic capacity of middle gluteal muscle in Thoroughbred horses
    D Eto
    Equine Research Institute, Japan Racing Association, 321 4 Tokami cho, Utsunomiya, 320 0856, Tochigi, Japan
    Res Vet Sci 76:139-44. 2004
    ..This study also highlighted a fact that high intensity training should be given with the great care to prevent the skeletal muscle injuries...
  93. ncbi Changes in physiological parameters in overtrained Standardbred racehorses
    M J Hamlin
    Department of Physiology, University of Otago, School of Medical Sciences, Dunedin, New Zealand
    Equine Vet J 34:383-8. 2002
    ..Bodyweight, V200, postexercise blood lactate and plasma cortisol concentrations may all be useful for detecting acute overtraining in equine athletes...
  94. ncbi Role of p53 in mitochondrial biogenesis and apoptosis in skeletal muscle
    Ayesha Saleem
    School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada
    Physiol Genomics 37:58-66. 2009
    ..These data illustrate a novel role for p53 in maintaining mitochondrial biogenesis, apoptosis, and performance in skeletal muscle...
  95. ncbi Early adaptations to training: upregulation of alpha-myosin heavy chain gene expression
    Karolina Rafalski
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Med Sci Sports Exerc 39:75-82. 2007
    ....
  96. pmc Rats selectively bred for low aerobic capacity have reduced hepatic mitochondrial oxidative capacity and susceptibility to hepatic steatosis and injury
    John P Thyfault
    Harry S Truman Memorial VA Hospital, Research Service, Columbia, MO 65201, USA
    J Physiol 587:1805-16. 2009
    ..We provide novel evidence that selection for low intrinsic aerobic capacity causes reduced hepatic mitochondrial oxidative capacity that increases susceptibility to both hepatic steatosis and liver injury...
  97. ncbi Regular voluntary exercise reduces anxiety-related behaviour and impulsiveness in mice
    Elke Binder
    Section of Behavioral Phenotyping, Max Planck Institute of Psychiatry, Munich D 80804, Germany
    Behav Brain Res 155:197-206. 2004
    ..Thus, our observations fit into the concept that regular exercise strengthens endogenous stress coping mechanisms, thereby protecting the organism against the deleterious effects of stress...
  98. ncbi Congenic strains confirm aerobic running capacity quantitative trait loci on rat chromosome 16 and identify possible intermediate phenotypes
    Justin A Ways
    Departments of Physiology, Pharmacology, Metabolism, and Cardiovascular Sciences, University of Toledo College of Medicine, Toledo, OH 43614, USA
    Physiol Genomics 29:91-7. 2007
    ..While this colocalization of QTLs may be coincidental, it is also possible that these differences in energy balance may be associated with the superior running performance of COP.DA(chr 16) consomic rats...
  99. ncbi Chronic hypoxia attenuates resting and exercise-induced VEGF, flt-1, and flk-1 mRNA levels in skeletal muscle
    I M Olfert
    Department of Physiology and Pharmacology, Loma Linda University, Loma Linda, California 92350, USA
    J Appl Physiol 90:1532-8. 2001
    ..These findings may provide an explanation for the lack of mammalian skeletal muscle angiogenesis that is observed after chronic hypoxia...
  100. ncbi Exercise preconditioning reduces brain damage and inhibits TNF-alpha receptor expression after hypoxia/reoxygenation: an in vivo and in vitro study
    Yun Hong Ding
    Department of Neurosurgery, The University of Texas Health Science Center at San Antonio, Mail Code 7843, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Curr Neurovasc Res 3:263-71. 2006
    ..Chronically increased TNF-alpha expression was also found to reduce TNFI and II responding to acute ischemia/reperfusion insult...
  101. ncbi The effect of physical exercise on the daily rhythm of platelet aggregation and body temperature in horses
    Giuseppe Piccione
    Department of Morphology, Biochemistry, Physiology and Animal Production, Laboratory of Veterinary Chronophysiology, Section of Veterinary Physiology, 98168 Messina, Italy
    Vet J 176:216-20. 2008
    ..The results could be interpreted as indicating that physical exercise has an influence on the daily rhythm of platelet aggregation in horses...

Research Grants74

  1. Development Stress, Exercise, and Vulnerability to Neuronal Injury
    Michael J Zigmond; Fiscal Year: 2010
    ....
  2. Veterinary Comparative Respiratory Society 2008 Symposium
    Michael Davis; Fiscal Year: 2008
    ..This symposium will review the current knowledge and practical challenges of these models in order to make them more accessible to the biomedical research community. [unreadable] [unreadable] [unreadable]..
  3. ANIMAL MODELS OF COLD AIR-INDUCED AIRWAY DISEASE
    Michael Davis; Fiscal Year: 2004
    ..The investigators will use these same measurements to determine the changes in pulmonary mechanics and airway inflammation in dogs that perform repeated exercise in frigid environments. ..
  4. NCRR Training Grant for Veterinary Students in Research
    Michael Davis; Fiscal Year: 2006
    ..Over a three-year period this program will contribute nine comparative medical scientists with veterinary medical degrees who are well trained in animal-oriented, hypothesis-based research. [unreadable] [unreadable]..
  5. Voluntary Exercise Therapy after Traumatic Brain Injury
    GRACE GRIESBACH; Fiscal Year: 2006
    ..In order to address these specific aims, I will utilize the lateral fluid-percussion injury model in rats and voluntary running wheel exposure. Protein, gene, histological and behavioral studies will be conducted. ..
  6. eNOS: Metabolism & Vascular Biology in Health & Disease
    M Laughlin; Fiscal Year: 2007
    ..The strong group of investigators submitting this application is uniquely qualified and prepared to accomplish these goals. ..
  7. MECHANICAL VENTILATION AND RESPIRATORY MUSCLES
    Scott Powers; Fiscal Year: 2004
    ..The long-term goal of our experiments is to provide the knowledge required to develop clinical strategies to oppose the deleterious effects of MV on respiratory muscles. ..
  8. Pulse Doppler Ultrasound Imaging System
    JOAN CARROLL; Fiscal Year: 2004
    ..abstract_text> ..
  9. SYSTOLIC CARDIAC FUNCTION IN OBESITY AND EXERCISE
    JOAN CARROLL; Fiscal Year: 2004
    ..Because such a large segment of the American population is overweight or obese, the knowledge and insight gained from these studies can have far-reaching effects. ..
  10. Physical Activity, Aging and Immune Function
    Jeffrey Woods; Fiscal Year: 2005
    ..In addition, the biobehavioral approach inherent in our aims will allow us to determine the complexity of the relationship between exercise and immune function. ..
  11. Exercise, Antioxidants, and I-R Injury
    Scott Powers; Fiscal Year: 2006
    ..abstract_text> ..
  12. Dietary Omega-3 Fatty Acids and Sudden Cardiac Death
    GEORGE EDWARD BILLMAN; Fiscal Year: 2010
    ..This project will also determine the effectiveness of fish oil supplements in reducing sudden death due to a lethal abnormal heart rhythm after a heart attack. ..
  13. Proteome Mapping of Heart Failure in Aging
    MARVIN BOLUYT; Fiscal Year: 2005
    ..Identification of proteins involved in aldosterone signaling will lead to the development of new hypotheses for future grant proposals addressing their roles in the development of heart failure in the elderly. ..
  14. Effect of Daily Exercise on Cardiac Autonomic Regulation
    GEORGE BILLMAN; Fiscal Year: 2005
    ..Ventricular contractile responses to Beta1- and Beta2-adrenoceptor stimulation will be examined in vivo by echocardiography and in vitro by single cell fluorescence microscopy/video edge detection. ..
  15. SYSTOLIC CARDIAC FUNCTION IN OBESITY AND EXERCISE
    JOAN CARROLL; Fiscal Year: 2004
    ..Because such a large segment of the American population is overweight or obese, knowledge and insight gained from these studies can have far-reaching effects. ..
  16. PHYSICAL ACTIVITY, ANTIDEPRESSANTS AND BDNF INDUCTION
    Amelia Russo Neustadt; Fiscal Year: 2008
    ..Knowledge about the mechanisms responsible for the enhancement of antidepressant response will inform the development of novel, more efficacious and rapid treatments. ..
  17. Mechanical Ventilation and Diaphragmatic Oxidant Injury
    Scott Powers; Fiscal Year: 2008
    ..abstract_text> ..
  18. Combination Therapy for Chronic Stroke-Induced Impairment
    J Leigh Leasure; Fiscal Year: 2008
    ..The proposed experiment will test a potential treatment for chronic stroke-related impairment in the aged brain. [unreadable] [unreadable] [unreadable]..
  19. Dorsomedial Hypothalamic Signaling Pathways and Energy Balance
    Sheng Bi; Fiscal Year: 2010
    ..Overall, the elucidation of the actions of these DMH peptide systems in feeding and body weight control would significantly advance our understanding of the role of this hypothalamic nucleus in maintaining energy homeostasis. ..
  20. Sympathetic Control in Heart Failure: A Role of Statins
    Irving H Zucker; Fiscal Year: 2010
    ..We will determine if a class of drugs called statins has the potential for reducing some of the deleterious consequences of compensatory mechanisms in the heart failure state. ..
  21. CHRONIC CORONARY OCCLUSION, EXERCISE TRAINING AND NO
    Cristine L Heaps; Fiscal Year: 2010
    ....
  22. Mechanisms to Induce Islet Proliferation
    PATRICK FUEGER; Fiscal Year: 2008
    ..This award will be an instrumental component towards my ultimate goal of pursuing a career in diabetes research. [unreadable] [unreadable]..
  23. Activity-Induced Recovery Following Brain Trauma
    Fernando Gomez Pinilla; Fiscal Year: 2008
    ..Therefore, the unique aspect of our proposal is to evaluate experience as a modulator of neuronal plasticity that can be used to enhance functional recovery following TBI. ..
  24. CANINE AS AN ANIMAL MODEL OF HUMAN AGING
    Carl Cotman; Fiscal Year: 2005
    ..Overall, this project should provide unique insight into the role of oxidative damage and subsequent molecular cascades on the progression of brain aging and cognitive decline. ..
  25. Changes in Functional Status Across Therapy for Primary Glioma
    Lee Jones; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  26. Effects of Myostatin Deficiency on Bone Strength
    Mark Hamrick; Fiscal Year: 2007
    ..abstract_text> ..
  27. Regulation of Oxidative Stress in the mdx Diaphragm
    JOHN LAWLER; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  28. Brain Aging & Gene Expression Patterns Using Microarrays
    Carl Cotman; Fiscal Year: 2007
    ..Once an initial primary paper is published the overall data will be made available to the field via NACC for various investigators to analyze for the testing their own hypotheses. ..
  29. Physical Activity Measurement in Older Adults
    Lisa Colbert; Fiscal Year: 2007
    ..This methodology can then be incorporated into future studies examining the associations between doses of physical activity and various health outcomes. [unreadable] [unreadable]..
  30. Genetic Analysis of Bone Structure and Strength
    Charles Turner; Fiscal Year: 2008
    ..abstract_text> ..
  31. Origins of Binaural Processing in Vertebrates
    Richard Fay; Fiscal Year: 2008
    ..abstract_text> ..
  32. Sound Source Segregation and Determination
    Richard Fay; Fiscal Year: 2007
    ..We will focus on understanding the dimensions of neural activity that the brain could use in segregating and integrating simultaneous acoustic components from one or more sources. [unreadable] [unreadable]..
  33. ABeta Immunization in Aging
    Carl Cotman; Fiscal Year: 2005
    ..Overall, this project should provide unique insight into the efficacy of immunization with fibrillar Abeta and have direct implications for the design of human clinical trials. ..
  34. Effect of Age on Exercise-Induced Cardioprotection
    JOSEPH STARNES; Fiscal Year: 2003
    ..The results of this Aim will provide key direction for the effective design of further comprehensive studies using inhibitors and/or activators of specific proteins or signaling pathways. ..
  35. MUSCLE CAPILLARY GEOMETRY, FLOW, AND OXYGEN TRANSFER
    David Poole; Fiscal Year: 2001
    ....
  36. ACTIVITY DEPENDENT PLASTICITY IN THE AGING BRAIN
    Carl Cotman; Fiscal Year: 2004
    ..Data from the proposed experiments will provide an initial characterization of how a simple, widely practiced activity-exercise-regulates expression of BDNF, a molecule increasingly recognized for its critical role in brain function. ..
  37. Dorsomedial Hypothalamic Pathways and Energy Balance
    Sheng Bi; Fiscal Year: 2005
    ..Together, these neurochemical and functional demonstrations will provide a clear view of the role of the DMH in energy balance ..
  38. Vascular tone and blood pressure control during exercise
    John Buckwalter; Fiscal Year: 2005
    ..This is an issue of fundamental importance that may have important implications for individuals with peripheral vascular disease. ..
  39. PHYSICAL ACTIVITY INDUCES NEUROTROPHIC FACTORS
    Fernando Gomez Pinilla; Fiscal Year: 2002
    ..Thirdly, the PI will determine whether locomotor deficit caused by degeneration of large muscle afferents (by using high doses of pyridoxine) can be countered by daily locomotion induction of neurotrophins. ..
  40. NEURAL MECHANISMS OF SOUND SOURCE IN VERTEBRATES
    Richard Fay; Fiscal Year: 2002
    ..These results will help in the development and evaluation of animal models for human hearing and help establish the comparative and evolutionary contexts within which the human sense of hearing can be better understood. ..
  41. APOPTOTIC INSULTS SUPPRESS MARKERS NEURONAL PLASTICITY
    Carl Cotman; Fiscal Year: 2004
    ..Together, these experiments may provide support for a mechanism (s) accounting for some of the well-known changes in brain aging and AD, including reduced activity dependent plasticity, synaptic integrity and neuronal survival. ..
  42. MECHANISMS OF PATHOLOGICAL NEURITIC & SOMAL DEGENERATION
    Carl Cotman; Fiscal Year: 2002
    ..The studies proposed in this application will provide new and basic biological findings potentially relevant to a wide array of normal and pathological events involving synaptic remodeling and neurite degeneration. ..
  43. NEUROTROPHIN REGULATION IN THE SPINAL CORD
    Fernando Gomez Pinilla; Fiscal Year: 2003
    ..abstract_text> ..
  44. DEFECTIVE ALPHA, ADRENERGIC SIGNALING IN SENESCENT RAT
    DONNA KORZICK; Fiscal Year: 2003
    ..Environment: The environment surrounding Dr. Korzick at the University of Missouri is one marked by a commitment to research and academic scholarship with major strengths in cardiovascular sciences. ..
  45. Instruments for measuring physical activity
    James Levine; Fiscal Year: 2008
    ..This should allow us to better define the role of physical activity in health and disease. ..
  46. Stress, Heat-Shock Proteins, and Innate Immunity
    Monika Fleshner; Fiscal Year: 2008
    ..abstract_text> ..
  47. Extracellular Matrix Remodeling and Tissue Mechanics
    DENISE HOCKING; Fiscal Year: 2004
    ....
  48. Cellular Mechanisms in the Pathogenesis of FHC
    JIL TARDIFF; Fiscal Year: 2006
    ..A better understanding of these processes may well lead to specific therapeutic interventions which could alter the malignant natural history of this disorder. ..
  49. Control of ATP Producing Pathways in Skeletal Muscle
    Brandon Walsh; Fiscal Year: 2005
    ..determine the role of metabolic channeling in setting the onset kinetics of oxidative phosphorylation, and 3.) determine the intracellular PO2 at which respiration becomes O2 dependent. ..
  50. Skeletal Muscle Microcirculation in Obese Zucker Rats
    Jefferson Frisbee; Fiscal Year: 2009
    ..abstract_text> ..
  51. Endothelial Deformation and Coronary Arteriolar Function
    Dong Sun; Fiscal Year: 2006
    ....
  52. PET Behavioral Brain Mapping In Freely Moving Animals
    DANIEL HOLSCHNEIDER; Fiscal Year: 2006
    ..Such knowledge may provide the basis of an improved integration of a functional brain anatomy in the context of mental disorders. ..
  53. Neurobiology of Musculoskeletal Pain
    Kathleen Sluka; Fiscal Year: 2005
    ..These proposed studies are intended to help in the understanding and thus potential treatment of chronic muscle pain including such conditions as fibromyalgia, myofascial pain and low back pain. ..
  54. Low Carbohydrate Diets: Feeding and Endocrine Signaling
    Timothy Moran; Fiscal Year: 2006
    ..abstract_text> ..
  55. Protein Tyrosine Phosphatase 1B and Insulin Action
    Barbara Kahn; Fiscal Year: 2005
    ..Our goal is to find new therapeutic targets to reduce insulin resistance and prevent or ameliorate type 2 diabetes. ..
  56. Dystrophic Cardiomyopathies in mdx
    DeWayne Townsend; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  57. Developmental Stress and Vulnerability to Brain Injury
    Michael Zigmond; Fiscal Year: 2004
    ..Moreover, the methods and reagents that we develop will be made available to others in the field. ..
  58. PRO-Surveyor: Device for Capturing Patient Reported Outcome Data in Children
    Nadine Connor; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  59. Mechanisms of Arrhythmia Suppression by Exercise Traini*
    HEIDI LUJAN; Fiscal Year: 2005
    ..This experience will provide for me the research skill to develop into an independent investigator and the scientific foundation to obtain external funds at the national level. ..
  60. A Rapid Immunoassay for Detection of Yersinia Pathogens
    John Glass; Fiscal Year: 2002
    ..Furthermore, this prototype assay will be reduced to a production model, validated for regulatory approval, and finalized for manufacture through a joint venture partner. ..
  61. Physiological Signals to MCT Expression
    George Brooks; Fiscal Year: 2008
    ..Aim 3 studies will involve comparisons of the levels of muscle MCT pre-mRNAs, mRNAs and protein levels. We have the tools to achieve the stated aims. ..
  62. The Role of Microsatellite Instability in Cancer
    Harold Garner; Fiscal Year: 2005
    ..We will also (Aim 3) investigate the effects of these mutations identified in Aim 2 on splicing by correlating them with the results of a quantitative global survey of splicing isoforms. ..
  63. ADAPTIVE BEHAVIOR AND BRAIN MONOAMINES
    Michael Zigmond; Fiscal Year: 2002
    ..The longer-term objectives of this project are to provide new insights into the basic neurobiology of LC neurons and the psychopathology that develops from chronic stress. ..
  64. TRAINING FACULTY TO TEACH SURVIVAL SKILLS AND ETHICS
    Michael Zigmond; Fiscal Year: 2005
    ..Efforts will be made to promote diversity with regard to the demographics of both the workshop participants and those they serve. Instruction will be provided by the PI's together with a highly qualified group of trainers. ..
  65. NEUROBIOLOGY OF CHRONIC MUSCLE PAIN
    Kathleen Sluka; Fiscal Year: 2003
    ..These proposed studies will help in the understanding and thus potential treatment of chronic muscle pain, including such conditions as fibromyalgia, myofascial pain and low back pain. ..
  66. Failed rescue of old skeletal muscle from atrophy
    Frank Booth; Fiscal Year: 2004
    ..Identifying the inappropriately expressed mRNAs associated with failed muscle regrowth of old muscles will permit a more scientifically-based growth factor rescue of old atrophied muscle. ..
  67. Role of ASIC3 in the etiology of fibromyalgia
    Kathleen A Sluka; Fiscal Year: 2010
    ..These studies could lead to peripherally based therapeutic approaches to control pain without undesirable CMS (central nervous system) side effects, including gene therapy. ..
  68. Proteomics: Inactivity-induced muscle insulin resistance
    Frank Booth; Fiscal Year: 2002
    ..Outcomes of this proposal will better establish that healthy active skeletal muscles interact with other organ systems to prevent the metabolic disorders of type 2 diabetes, atherosclerosis, and obesity. ..
  69. Regulation of skeletal alpha actin expression during mu*
    Espen Spangenburg; Fiscal Year: 2008
    ..The overall goal is to determine the role IGF-I may have in activating transcriptional activity during muscle regrowth. ..
  70. STRUCTURAL DETERMINANTS OF NEUROENDOCRINE RECEPTORS
    Carrie Haskell Luevano; Fiscal Year: 2008
    ..abstract_text> ..
  71. ACTIONS OF OPIATE DRUGS--DIETARY MODULATION
    ROBIN KANAREK; Fiscal Year: 2002
    ....
  72. Human Melanocortin-4 Receptor Polymorphisms
    Carrie Haskell Luevano; Fiscal Year: 2007
    ..Understanding obesity related mechanisms may ultimately result in therapeutic agents to prevent or treat the diseases associated with over eating. ..