Genomes and Genes
animal physical conditioning
Summary: Physical conditioning of domestic, laboratory, and zoo animals. Includes exercising of animals.
Publications268 found, 100 shown here
- Role of AMP-activated protein kinase in exercise capacity, whole body glucose homeostasis, and glucose transport in skeletal muscle -insight from analysis of a transgenic mouse model-Nobuharu Fujii
Research Division, Joslin Diabetes Center, and the Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, One Joslin Place, Boston, MA 02215, USA
Diabetes Res Clin Pract 77:S92-8. 2007..However, contraction- or hyperosmolarity-induced glucose transport was nearly normal. These results suggest that AMPK alpha2 activation is essential for some, but not all insulin-independent glucose transport...
- Muscle-specific expression of PPARgamma coactivator-1alpha improves exercise performance and increases peak oxygen uptakeJennifer A Calvo
Novartis Institutes for BioMedical Research, 100 Technology Square, Cambridge, MA 02139, USA
J Appl Physiol (1985) 104:1304-12. 2008..Thus this study demonstrates that upregulation of PGC-1alpha in muscle in vivo is sufficient to greatly improve exercise performance under various exercise paradigms as well as increase peak oxygen uptake...
- Exhaustive exercise causes an anti-inflammatory effect in skeletal muscle and a pro-inflammatory effect in adipose tissue in ratsJosé C Rosa Neto
Department of Physiology of Nutrition, Federal University of Sao Paulo, Sao Paulo, SP CEP 04023 060, Brazil
Eur J Appl Physiol 106:697-704. 2009....
- Exercise and the immune system: regulation, integration, and adaptationB K Pedersen
Department of Infectious Diseases and Copenhagen Muscle Research Centre, University of Copenhagen, Copenhagen, Denmark
Physiol Rev 80:1055-81. 2000..Accordingly, drawing on the experimental, clinical, and epidemiological literature, we address the interactions between exercise and infectious diseases as well as exercise and neoplasia within the context of both aging and nutrition...
- Cardiovascular risk factors emerge after artificial selection for low aerobic capacityUlrik Wisløff
Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Olav Kyrres gt 3, 7489 Trondheim, Norway
Science 307:418-20. 2005..Impairment of mitochondrial function may link reduced fitness to cardiovascular and metabolic disease...
- Skeletal muscle adaptation to exercise training: AMP-activated protein kinase mediates muscle fiber type shiftKatja S C Röckl
Research Division, Joslin Diabetes Center and Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts 02215, USA
Diabetes 56:2062-9. 2007..AMPK is not necessary for exercise training-induced increases in mitochondrial markers, but it is essential for fiber type IIb to IIa/x transformation and increases in hexokinase II protein...
- Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's diseasePaul A Adlard
Institute for Brain Aging and Dementia, University of California, Irvine, Irvine, California 92697 4540, USA
J Neurosci 25:4217-21. 2005..In support of existing epidemiological studies, this investigation demonstrates that exercise is a simple behavioral intervention sufficient to inhibit the normal progression of AD-like neuropathology in the TgCRND8 mouse model...
- AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolismBarbara B Kahn
Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
Cell Metab 1:15-25. 2005..Through signaling, metabolic, and gene expression effects, AMPK enhances insulin sensitivity and fosters a metabolic milieu that may reduce the risk for obesity and type 2 diabetes...
- Regulation of muscle fiber type and running endurance by PPARdeltaYong Xu Wang
Gene Expression Laboratory, Salk Institute, La Jolla, California, USA
PLoS Biol 2:e294. 2004..These results demonstrate that complex physiologic properties such as fatigue, endurance, and running capacity can be molecularly analyzed and manipulated...
- Exercise induces behavioral recovery and attenuates neurochemical deficits in rodent models of Parkinson's diseaseJ L Tillerson
Institute for Neuroscience, University of Texas at Austin, Austin, TX, 78712, USA
Neuroscience 119:899-911. 2003..These results demonstrate that exercise following nigrostriatal damage ameliorates related motor symptoms and neurochemical deficits in rodent models of PD...
- The effects of forced exercise on hippocampal plasticity in the rat: A comparison of LTP, spatial- and non-spatial learningRobert Ohle
Department of Physiology, School of Medicine, University of Dublin, Trinity College, Dublin 2, Ireland
Behav Brain Res 176:362-6. 2007..Spatial learning in the Morris watermaze was unaffected by exercise. These changes were associated with an increase in expression of brain-derived neurotrophic factor in the dentate gyrus...
- Habitual low-intensity exercise does not protect against myocardial dysfunction after ischemia in ratsJoseph W Starnes
Department of Kinesiology and Health Education, Cardiac Metabolism Laboratory, University of Texas, Austin, Texas 78712, USA
Eur J Cardiovasc Prev Rehabil 12:169-74. 2005..Thus, the purpose of this study is to determine whether low-intensity exercise provides self-protection to the heart against I-R injury...
- Moderate vs. high exercise intensity: differential effects on aerobic fitness, cardiomyocyte contractility, and endothelial functionOle J Kemi
Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
Cardiovasc Res 67:161-72. 2005..We therefore assessed relative effectiveness of 10-week HIGH versus moderate (MOD) exercise intensity on integrative and cellular functions...
- Intensity-controlled treadmill running in mice: cardiac and skeletal muscle hypertrophyOle Johan Kemi
Department of Physiology and Biomedical Engineering, Norwegian University of Science and Technology, N 7489 Trondheim, Norway
J Appl Physiol 93:1301-9. 2002..Thus the model mimics human responses to exercise and can be used in future studies of molecular mechanisms underlying these adaptations...
- Mechanisms of stroke protection by physical activityMatthias Endres
Klinik und Poliklinik fur Neurologie, Charite, Humboldt Universitat zu Berlin, Schumannstrasse 20 21, D 10117 Berlin, Germany
Ann Neurol 54:582-90. 2003..Our results suggest that physical activity not only decreases stroke risk, but also provides a prophylactic treatment strategy for increasing blood flow and reducing brain injury during cerebral ischemia...
- Voluntary exercise produces antidepressant and anxiolytic behavioral effects in miceCatharine H Duman
Division of Molecular Psychiatry, Abraham Ribicoff Research Facilities, Department of Psychiatry and Pharmacology, Yale University School of Medicine, New Haven, CT 06508, USA
Brain Res 1199:148-58. 2008..In summary, chronic wheel-running exercise in mice results in antidepressant-like behavioral changes that may involve a BDNF related mechanism similar to that hypothesized for antidepressant drug treatment...
- VEGF gradients, receptor activation, and sprout guidance in resting and exercising skeletal muscleFeilim Mac Gabhann
Dept of Biomedical Engineering, Johns Hopkins Univ School of Medicine, 720 Rutland Ave, Baltimore, MD 2120, USA
J Appl Physiol (1985) 102:722-34. 2007..e., perpendicular to the muscle fibers) than in the longitudinal direction. This may explain observed perpendicular anastomoses in skeletal muscle...
- Exercise restores endothelial function independently of weight loss or hyperglycaemic status in db/db miceF Moien-Afshari
Department of Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada
Diabetologia 51:1327-37. 2008....
- PGC-1alpha mediates exercise-induced skeletal muscle VEGF expression in miceLotte Leick
Department of Biology, University of Copenhagen, Universitetsparken 13, 2100 Copenhagen, Denmark
Am J Physiol Endocrinol Metab 297:E92-103. 2009..Furthermore, the findings suggest an AMPK-mediated regulation of VEGF expression through PGC-1alpha...
- Effects of high intensity exercise training on cardiovascular function, oxygen uptake, internal oxygen transport and osmotic balance in chinook salmon (Oncorhynchus tshawytscha) during critical speed swimmingP E Gallaugher
Continuing Studies in Science, Simon Fraser University, Burnaby, BC, Canada
J Exp Biol 204:2861-72. 2001..99) among temperate fish species, it is likely that CaO2 and Qmax are principal loci for cardiorespiratory evolutionary adaptation but not for intraspecific cardiorepiratory plasticity as revealed by high intensity exercise training...
- Aerobic interval training enhances cardiomyocyte contractility and Ca2+ cycling by phosphorylation of CaMKII and Thr-17 of phospholambanOle J Kemi
Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
J Mol Cell Cardiol 43:354-61. 2007..These observations indicate that calcium/calmodulin-dependent kinase IIdelta contributes significantly to the functional adaptation of the cardiomyocyte to regular exercise training...
- Long-term locomotor training up-regulates TrkB(FL) receptor-like proteins, brain-derived neurotrophic factor, and neurotrophin 4 with different topographies of expression in oligodendroglia and neurons in the spinal cordMalgorzata Skup
Department of Neurophysiology, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur St 02 093 Warsaw, Poland
Exp Neurol 176:289-307. 2002..Oligodendrocytes of the spinal gray matter were particularly responsive to exercise, pointing to their involvement in activity-driven cross talk between neurons and glia...
- Acute physical exercise reverses S-nitrosation of the insulin receptor, insulin receptor substrate 1 and protein kinase B/Akt in diet-induced obese Wistar ratsJose R Pauli
Departamento de Clinica Medica, FCM UNICAMP, Universidade Estadual de Campinas, Campinas, SP, Brasil
J Physiol 586:659-71. 2008..These results provide new insights into the mechanism by which exercise restores insulin sensitivity...
- Exercise training changes autonomic cardiovascular balance in miceK De Angelis
Hypertension Unit, Heart Institute University of São Paulo, Medical School, 05403 000 Sao Paulo, Brazil
J Appl Physiol 96:2174-8. 2004..These changes are likely related to an increased vagal and decreased sympathetic tone, similar to the exercise response observed in humans...
- Psychological stress increases histone H3 phosphorylation in adult dentate gyrus granule neurons: involvement in a glucocorticoid receptor-dependent behavioural responseAlicia Bilang-Bleuel
Max Planck Institute of Psychiatry, Section of Neuropsychopharmacology, Munich, Germany
Eur J Neurosci 22:1691-700. 2005....
- Increased astrocyte proliferation in rats after running exerciseJie Li
Department of Neurological Surgery, Wayne State University School of Medicine, Canfield, Detroit, MI 48201, USA
Neurosci Lett 386:160-4. 2005..Strengthening of this unit by exercise may protect blood-brain-barrier function following brain injury, such as that occurring after stroke...
- Tenocyte responses to mechanical loading in vivo: a role for local insulin-like growth factor 1 signaling in early tendinosis in ratsAlexander Scott
University of British Columbia, Vancouver, British Columbia, Canada
Arthritis Rheum 56:871-81. 2007..To investigate tenocyte regulatory events during the development of overuse supraspinatus tendinosis in rats...
- Intact neurogenesis is required for benefits of exercise on spatial memory but not motor performance or contextual fear conditioning in C57BL/6J miceP J Clark
Department of Psychology, The Beckman Institute, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
Neuroscience 155:1048-58. 2008..Results support the hypothesis that intact exercise-induced hippocampal neurogenesis is required for improved spatial memory, but not motor performance or contextual fear in C57BL/6J mice...
- Free radicals generated by contracting muscle: by-products of metabolism or key regulators of muscle function?Malcolm J Jackson
Division of Metabolic and Cellular Medicine, School of Clinical Sciences, University of Liverpool, Liverpool L69 3GA, UK
Free Radic Biol Med 44:132-41. 2008....
- Exercise-induced behavioral recovery and neuroplasticity in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse basal gangliaBeth E Fisher
Department of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, California 90033, USA
J Neurosci Res 77:378-90. 2004..Our data demonstrates that exercise promotes behavioral recovery in the injured brain by modulating genes and proteins important to basal ganglia function...
- Protective effects of treadmill training on infarction in ratsR Y Wang
Faculty of Physical Therapy, National Yang Ming University, 155, Section 2, Li Nong Street, Shih Pai, Taipei, Taiwan
Brain Res 922:140-3. 2001..01). The present study provides evidence that treadmill training reduces ischemic brain damage in an animal model of cerebral ischemia...
- Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesisJason Brown
Department of Neurology, University of Regensburg, 93053 Regensburg, Germany
Eur J Neurosci 17:2042-6. 2003..The discrepancy between the olfactory bulb and the dentate gyrus suggests that these living conditions trigger locally through an as yet unidentified mechanism specific to neurogenic signals in the dentate gyrus...
- Physical activity elicits sustained activation of the cyclic AMP response element-binding protein and mitogen-activated protein kinase in the rat hippocampusH Shen
Institute for Brain Aging and Dementia, University of California, Irvine, CA 92697-4540, USA
Neuroscience 107:219-29. 2001....
- Locomotor exercise alters expression of pro-brain-derived neurotrophic factor, brain-derived neurotrophic factor and its receptor TrkB in the spinal cord of adult ratsMatylda Macias
Department of Neurophysiology, Nencki Institute of Experimental Biology, 3 Pasteur Street, 02 093 Warsaw, Poland
Eur J Neurosci 25:2425-44. 2007....
- Genetic expression profiles during physiological and pathological cardiac hypertrophy and heart failure in ratsSek Won Kong
Cardiovascular Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
Physiol Genomics 21:34-42. 2005..In addition, there were significant changes in glucose/insulin signaling, protein biosynthesis, and epidermal growth factor signaling during physiological hypertrophy but not during pathological hypertrophy...
- The exercise-induced expression of BDNF within the hippocampus varies across life-spanPaul A Adlard
Institute for Brain Aging and Dementia, University of California, 1125 Gillespie N R F, Irvine, CA 92697 4540, USA
Neurobiol Aging 26:511-20. 2005..BDNF protein induction may, therefore, not be directly correlated with significant mRNA changes. Exercise may represent a therapeutic tool for disorders which involve a decrease in BDNF...
- Exercise primes a molecular memory for brain-derived neurotrophic factor protein induction in the rat hippocampusN C Berchtold
Institute for Brain Aging and Dementia, 1226 Gillespie Neuroscience Facility, University of California, Irvine, CA 92697 4540, USA
Neuroscience 133:853-61. 2005..These findings are clinically important because they provide guidelines for optimizing the design of exercise and rehabilitation programs, in order to promote hippocampal function...
- Exercise attenuates diabetes-induced ultrastructural changes in rat cardiac tissueYvonne M Searls
Departments of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS, USA
Med Sci Sports Exerc 36:1863-70. 2004..This study sought to explore the effects of endurance exercise on the ultrastructural changes seen in diabetic cardiomyopathy...
- Exercise training improves muscle insulin resistance but not insulin receptor signaling in obese Zucker ratsChristine Y Christ
Department of Physiology, University of Texas Health Sciences Center, San Antonio, Texas 78712, USA
J Appl Physiol 92:736-44. 2002....
- Exercise, antioxidants, and HSP72: protection against myocardial ischemia/reperfusionKaryn L Hamilton
Department of Exercise and Sport Science, Center for Exercise Science, University of Florida, Gainesville, FL 32611, USA
Free Radic Biol Med 34:800-9. 2003....
- Development and characterization of an overtraining animal modelRodrigo Hohl
Laboratory of Exercise Biochemistry LABEX, Biochemistry Department, Biology Institute, State University of Campinas UNICAMP, Campinas, Brazil
Med Sci Sports Exerc 41:1155-63. 2009..Development of an endurance training-overtraining protocol for Wistar rats that includes increased workload and is characterized by analyses of performance and biomarkers...
- Distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampusChunmei Zhao
Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, California 92037, USA
J Neurosci 26:3-11. 2006..Our study reveals the key morphological transitions of newborn granule neurons during their course of maturation...
- Exercise-induced promotion of hippocampal cell proliferation requires beta-endorphinM Koehl
Centre de Recherche INSERM U862, Physiopathologie de la Plasticité Neuronale, 146 rue Leo Saignat, 33077 Bordeaux Cedex, France
FASEB J 22:2253-62. 2008..We conclude that beta-endorphin released during running is a key factor for exercise-induced cell proliferation and that a homeostatic balance may regulate the final number of new neurons...
- Treadmill training ameliorates dopamine loss but not behavioral deficits in hemi-parkinsonian ratsNadine P Poulton
Biomedical Sciences, WCVM, University of Saskatchewan, 52 Campus Drive, Saskatoon, SK, Canada S7N 5B4
Exp Neurol 193:181-97. 2005..We conclude that treadmill training does not ameliorate locomotor deficits in the 6-OHDA model of Parkinson's disease, even though this same training results in attenuation of dopamine loss in the striatum...
- Functional recovery in rats with chronic spinal cord injuries after exposure to an enriched environmentFlorence R Fischer
Wayne State University School of Medicine, 8137 Scott Hall, 540 E Canfield Avenue, Detroit, MI 48201, USA
J Spinal Cord Med 30:147-55. 2007..The objective of this study was to determine the effect of environmental enrichment on the sensorimotor function of rats with chronic spinal cord injuries...
- Temporal thrombospondin-1 mRNA response in skeletal muscle exposed to acute and chronic exerciseI Mark Olfert
Division of Physiology, Department of Medicine, University of California San Diego, La Jolla, CA 92093 0623, USA
Growth Factors 24:253-9. 2006....
- Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1Keith Baar
Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
FASEB J 16:1879-86. 2002..These findings suggest that increases in PGC-1, NRF-1, and NRF-2 represent key regulatory components of the stimulation of mitochondrial biogenesis by exercise and that PGC-1 mediates the coordinated increases in GLUT4 and mitochondria...
- Inhibitory effects of voluntary running wheel exercise on UVB-induced skin carcinogenesis in SKH-1 miceLaura Michna
Joint Graduate Program in Toxicology, The State University of New Jersey, Piscataway, NJ 08854, USA
Carcinogenesis 27:2108-15. 2006..The effects described here indicate that voluntary running wheel exercise inhibits UVB-induced skin tumorigenesis and may also inhibit tumor growth...
- VEGF is necessary for exercise-induced adult hippocampal neurogenesisKlaus Fabel
Department of Neurosurgery, Mail Code 5487, MSLS P309, 1201 Welch Rd, Stanford University, Stanford, CA 94305 5487, USA
Eur J Neurosci 18:2803-12. 2003....
- Insulin-like growth factor I interfaces with brain-derived neurotrophic factor-mediated synaptic plasticity to modulate aspects of exercise-induced cognitive functionQ Ding
Department of Physiological Science, UCLA, 621 Charles E Young Drive, Los Angeles, CA 90095, USA
Neuroscience 140:823-33. 2006..Our results illustrate a possible mechanism by which insulin-like growth factor-I interfaces with the brain-derived neurotrophic factor system to mediate exercise-induced synaptic and cognitive plasticity...
- Cardiac and skeletal muscle adaptations to voluntary wheel running in the mouseD L Allen
Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder 80309 0347, USA
J Appl Physiol (1985) 90:1900-8. 2001..All results are relative to age-matched mice housed without access to running wheels. Together these data demonstrate that voluntary exercise in mice results in cardiac and skeletal muscle adaptations consistent with endurance exercise...
- Effects of sprint exercise on oxidative stress in skeletal muscle and liverBerkant Muammer Kayatekin
Dokuz Eylul University Medical School, Department of Physiology, 35340 Balcova, Izmir, Turkey
Eur J Appl Physiol 87:141-4. 2002..In conclusion, acute sprint exercise in mice resulted in an increase in TBARS levels in skeletal muscle; no change was observed in the liver. Antioxidant enzyme activities remained unaffected by acute sprint exercise in these tissues...
- Exercise restores levels of neurotrophins and synaptic plasticity following spinal cord injuryZhe Ying
Department of Physiological Science, UCLA, Los Angeles, CA 90095 1527, USA Division of Neurosurgery, UCLA Brain Injury Research Center, Los Angeles, CA 90095 1527, USA
Exp Neurol 193:411-9. 2005..These results are consistent with the concept that synaptic pathways under the regulatory role of BDNF induced by exercise can play a role in facilitating recovery of locomotion following spinal cord injury...
- Exercise preconditioning upregulates cerebral integrins and enhances cerebrovascular integrity in ischemic ratsY H Ding
Department of Neurological Surgery, Wayne State University School of Medicine, Detroit, MI, USA
Acta Neuropathol 112:74-84. 2006..The study suggests that upregulation of integrins during exercise enhances neurovascular integrity after stroke. The changes in integrins might be altered by TNF-alpha...
- Functional, structural and molecular plasticity of mammalian skeletal muscle in response to exercise stimuliMartin Fluck
Unit for Functional Anatomy, Department of Anatomy, University of Berne, Baltzerstrasse 2, Switzerland
J Exp Biol 209:2239-48. 2006..The identification of the basic relationships underlying the malleability of muscle tissue is likely to be of relevance for our understanding of compensatory processes in other tissues, species and organisms...
- Role of exercise training in cardiovascular autonomic dysfunction and mortality in diabetic ovariectomized ratsSilvia B C Souza
Hypertension Unit, Heart Institute InCor, University of Sao Paulo Medical School, Sao Paulo, Brazil
Hypertension 50:786-91. 2007....
- Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR deltaDeborah M Muoio
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 277:26089-97. 2002....
- Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognitionShoshanna Vaynman
Department of Physiological Science, UCLA, 621 Charles E Young Drive, Los Angeles, CA 90095, USA
Eur J Neurosci 20:2580-90. 2004..These findings suggest a functional role for CREB under the control of BDNF in mediating the exercise-induced enhancement in learning and memory. Our results indicate that synapsin I might also contribute to this BDNF-mediated mechanism...
- The combination of dietary conjugated linoleic acid and treadmill exercise lowers gain in body fat mass and enhances lean body mass in high fat-fed male Balb/C miceArunabh Bhattacharya
Department of Medicine, Division of Clinical Immunology, University of Texas Health Science Center, San Antonio 78229 3900, USA
J Nutr 135:1124-30. 2005....
- Interplay between brain-derived neurotrophic factor and signal transduction modulators in the regulation of the effects of exercise on synaptic-plasticityS Vaynman
Department of Physiological Science, UCLA, 621 Charles E Young Drive, Los Angeles, CA 90095, USA
Neuroscience 122:647-57. 2003..Since these molecules have a well-described association to BDNF action, our results illustrate a basic mechanism through which exercise may promote synaptic-plasticity in the adult brain...
- AMPK and PPARdelta agonists are exercise mimeticsVihang A Narkar
Gene Expression Laboratory, Salk Institute, La Jolla, CA 92037, USA
Cell 134:405-15. 2008..These results demonstrate that AMPK-PPARdelta pathway can be targeted by orally active drugs to enhance training adaptation or even to increase endurance without exercise...
- Physical exercise prevents age-related decline in precursor cell activity in the mouse dentate gyrusGolo Kronenberg
Max Delbruck Center for Molecular Medicine, Berlin Buch, Robert Rossle Str 10, 13125 Berlin, Germany
Neurobiol Aging 27:1505-13. 2006..We propose that physical activity might contribute to successful aging by increasing the potential for neurogenesis represented by the pool of proliferating precursor cells...
- Selective activation of AMPK-PGC-1alpha or PKB-TSC2-mTOR signaling can explain specific adaptive responses to endurance or resistance training-like electrical muscle stimulationP J Atherton
School of Life Sciences, University of Dundee, UK
FASEB J 19:786-8. 2005..We term this behavior the "AMPK-PKB switch." We hypothesize that the AMPK-PKB switch is a mechanism that partially mediates specific adaptations to endurance and resistance training, respectively...
- AMPK activity is diminished in tissues of IL-6 knockout mice: the effect of exerciseMeghan Kelly
Diabetes Unit, Section of Endocrinology, Boston Medical Center and Departments of Medicine and Physiology, Boston University School of Medicine, Boston, MA 02118, USA
Biochem Biophys Res Commun 320:449-54. 2004..They also suggest that a genetic lack of IL-6 is associated with a decrease in AMPK activity...
- The molecular bases of training adaptationVernon G Coffey
School of Medical Sciences, Exercise Metabolism Group, RMIT University, Melbourne, Victoria, Australia
Sports Med 37:737-63. 2007..This article highlights the effects of exercise on molecular and genetic mechanisms of training adaptation in skeletal muscle...
- Voluntary exercise improves insulin sensitivity and adipose tissue inflammation in diet-induced obese miceRichard L Bradley
Dept of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Am J Physiol Endocrinol Metab 295:E586-94. 2008..These results suggest that exercise partially reduces adiposity, reverses insulin resistance and decreases adipose tissue inflammation in diet-induced obese mice, despite continued consumption of HFD...
- MicroRNA-1 and microRNA-133a expression are decreased during skeletal muscle hypertrophyJohn J McCarthy
Department of Physiology, University of Kentucky Medical Center, 800 Rose St, Lexington, KY 40536 0298, USA
J Appl Physiol (1985) 102:306-13. 2007..These results are the first to report alterations in expression of muscle-specific miRNAs in adult skeletal muscle and suggest miRNAs may have a role in the adaptation to functional overload...
- Effects of low-intensity prolonged exercise on PGC-1 mRNA expression in rat epitrochlearis muscleShin Terada
Laboratory of Exercise Physiology, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku City, Tokyo, Japan
Biochem Biophys Res Commun 296:350-4. 2002..These results may suggest that an acute bout of low-intensity prolonged swimming exercise directly enhances the PGC-1 mRNA expression in the activated muscle during exercise, possibly through, at least in part, an AMPK-related mechanism...
- Activation of MEF2 by muscle activity is mediated through a calcineurin-dependent pathwayH Wu
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
EMBO J 20:6414-23. 2001....
- Peroxisome proliferator-activated receptor delta controls muscle development and oxidative capabilitySerge Luquet
INSERM U470, Centre de Biochimie, Parc Valrose, Universite de Nice Sophia Antipolis, 06108 Nice Cedex 2, France
FASEB J 17:2299-301. 2003..They strongly support the idea that activation of PPARdelta could be beneficial in prevention of metabolic disorders, such as obesity or type 2 diabetes...
- Reversal of diet-induced insulin resistance with a single bout of exercise in the rat: the role of PTP1B and IRS-1 serine phosphorylationEduardo R Ropelle
Departamento de Clinica, Medica, FCM UNICAMP, Cidade Universitaria Zeferino Vaz, Campinas, Sao Paulo, Brazil, 13081 970
J Physiol 577:997-1007. 2006..Thus, acute exercise increased the insulin sensitivity during high-fat feeding in obese rats. Overall, these results provide new insights into the mechanism by which exercise restores insulin sensitivity...
- Physical activity and the regulation of neurogenesis in the adult and aging brainKlaus Fabel
Center for Regenerative Therapies Dresden, DFG Forschungszentrum und Exzellenzcluster, Tatzberg 47 49, 01307 Dresden, Germany
Neuromolecular Med 10:59-66. 2008..This would also explain why few new neurons could be beneficial for successful aging. We here review the current stage of the knowledge how this exercise-induced regulation of neurogenesis might work...
- Differential effects of voluntary physical exercise on behavioral and brain-derived neurotrophic factor expression deficits in Huntington's disease transgenic miceT Y C Pang
Howard Florey Institute, University of Melbourne, Parkville, Victoria 3010, Australia
Neuroscience 141:569-84. 2006..In addition, our results reveal that some aspects of hippocampal dependent memory are not entirely reliant on sustained hippocampal brain-derived neurotrophic factor expression...
- Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animalsChristoph Handschin
Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 282:30014-21. 2007..Our data demonstrate a critical role for PGC-1alpha in maintenance of normal fiber type composition and of muscle fiber integrity following exertion...
- Exercise training restores abnormal myocardial glucose utilization and cardiac function in diabetesTom L Broderick
Department of Physiology, Midwestern University, 19555 59th Avenue, Glendale, AZ 85308, USA
Diabetes Metab Res Rev 21:44-50. 2005..This study determined whether exercise training could prevent the depression in glucose utilization observed in the diabetic rat heart...
- Overexpression of the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) in skeletal muscle repatterns energy metabolism in the mouseParvin Hakimi
Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, OH 44106 4935, USA
J Biol Chem 282:32844-55. 2007..5 years ran twice as fast as 6-12-month-old control animals. We conclude that overexpression of PEPCK-C repatterns energy metabolism and leads to greater longevity...
- Voluntary exercise-induced changes in beta2-adrenoceptor signalling in rat ventricular myocytesRachel Stones
Institute of Membrane and Systems Biology, The University of Leeds, Leeds LS2 9JT, UK
Exp Physiol 93:1065-75. 2008....
- Exercise improves insulin and leptin sensitivity in hypothalamus of Wistar ratsMarcelo B S Flores
Department of Internal Medicine, State University of Campinas UNICAMP, 13081 970 Campinas, SP, Brazil
Diabetes 55:2554-61. 2006..These findings provide support for the hypothesis that the appetite-suppressive actions of exercise may be mediated by the hypothalamus...
- Short and long-term motor skill learning in an accelerated rotarod training paradigmManuel M Buitrago
Department of General Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Hoppe Seyler Strasse 3, Tubingen 72076, Germany
Neurobiol Learn Mem 81:211-6. 2004..Accelerated rotarod training can be regarded a valid paradigm for motor skill learning over short (intrasession, minutes) and long time frames (intersession, days)...
- Can an external device prevent dorsal displacement of the soft palate during strenuous exercise?J B Woodie
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
Equine Vet J 37:425-9. 2005..In light of recent findings that suggested the position of the larynx may influence the occurrence of DDSP, we investigated whether a noninvasive mean of affecting the position of the larynx could be effective in the management of DDSP...
- Effect of growth and training on muscle adaptation in Thoroughbred horsesSeiko Yamano
Department of Biological Sciences, Faculty of Agriculture, Yamaguchi University, Japan
Am J Vet Res 63:1408-12. 2002..To determine the effect of growth and training on metabolic properties in muscle fibers of the gluteus medius muscle in adolescent Thoroughbred horses...
- Alterations in oxidative gene expression in equine skeletal muscle following exercise and trainingSuzanne S Eivers
Animal Genomics Laboratory, University College Dublin School of Agriculture, Food Science and Veterinary Medicine, Dublin, Ireland
Physiol Genomics 40:83-93. 2010..These data highlight the roles of genes responsible for the regulation of oxygen-dependent metabolism, glucose metabolism, and fatty acid utilization in equine skeletal muscle adaptation to exercise...
- Changes in the rat heart proteome induced by exercise training: Increased abundance of heat shock protein hsp20Marvin O Boluyt
Center for Exercise Research, Division of Kinesiology, The University of Michigan, Laboratory of Molecular Kinesiology, 401 Washtenaw Avenue, Ann Arbor, MI 48109, USA
Proteomics 6:3154-69. 2006..Thus, exercise training alters the cardiac proteome of the rat heart; the changes include a marked increase in the expression of hsp20...
- Exercise training alters the molecular response to myocardial infarctionSarit Freimann
Neufeld Cardiac Research Institute, Tel Aviv University, Ramat Aviv, Israel
Med Sci Sports Exerc 41:757-65. 2009..The purpose of the current study was to identify temporal changes in the molecular response to myocardial infraction of prior exercise trained rats during the acute, the subacute, and the chronic phases postinfarction...
- cDNA Cloning and mRNA analysis of PGC-1 in epitrochlearis muscle in swimming-exercised ratsM Goto
Molecular Medicine Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Company, Ltd, 21 Miyukigaoka, Tsukuba, Ibaraki, 305 8585, Japan
Biochem Biophys Res Commun 274:350-4. 2000..These results demonstrate that expression of the PGC-1 gene in Epi muscle is induced not only by cold exposure but also by prolonged low-intensity physical exercise...
- Analysis of peripheral blood mononuclear cells gene expression in endurance horses by cDNA-AFLP techniqueKatia Cappelli
Centro di Studio del Cavallo Sportivo, Facolta di Medicina Veterinaria, University of Perugia, Via San Costanzo 4, 06126 Perugia, Italy
Res Vet Sci 82:335-43. 2007..caballus heat shock protein 90 (Hsp90). The expression pattern of these genes was verified in other endurance horses under stressing conditions, strengthening the hypothesis of their real involvement in exercise stress-induced response...
- Effects of exercise on Pavlovian fear conditioningDavid E Baruch
Department of Psychology, University of Wisconsin, Milwaukee, WI 53201, USA
Behav Neurosci 118:1123-7. 2004..The enhancement of contextual fear conditioning provides further evidence that exercise alters hippocampal function and learning...
- Effects of exercise training on pathological cardiac hypertrophy related gene expression and apoptosisYoung I Lee
Exercise Biochemistry Laboratory, Korea National Sport University, 88 15 Oryun dong, 138 763, Songpa Gu, Seoul, Korea
Eur J Appl Physiol 97:216-24. 2006....
- Influence of voluntary exercise on hypothalamic norepinephrineG W Lambert
Institute of Physiology and Pharmacology, Department of Physiology, Goteborg University, 41390 Goteborg, Sweden
J Appl Physiol (1985) 85:962-6. 1998....
- Hypothalamus, hypertension, and exerciseJ M Kramer
Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
Brain Res Bull 53:77-85. 2000..These findings describe a potential mechanism by which chronic exercise lowers blood pressure in the hypertensive individual...
- Heavy load exercise induced dysfunction of immunity and neuroendocrine responses in ratsChen Peijie
Department of Sports Medicine, Shanghai Institute of Physical Education, Shanghai 200438, China
Life Sci 72:2255-62. 2003..These data suggest that 6-week heavy load training induces the dysfunction of immunity and neuroendocrine responses, which might be one of the underlying mechanisms of immune dysfunction in overtraining...
- Effect of high intensity training on anaerobic capacity of middle gluteal muscle in Thoroughbred horsesD Eto
Equine Research Institute, Japan Racing Association, 321 4 Tokami cho, Utsunomiya, 320 0856, Tochigi, Japan
Res Vet Sci 76:139-44. 2004..This study also highlighted a fact that high intensity training should be given with the great care to prevent the skeletal muscle injuries...
- Changes in physiological parameters in overtrained Standardbred racehorsesM J Hamlin
Department of Physiology, University of Otago, School of Medical Sciences, Dunedin, New Zealand
Equine Vet J 34:383-8. 2002..Bodyweight, V200, postexercise blood lactate and plasma cortisol concentrations may all be useful for detecting acute overtraining in equine athletes...
- Role of p53 in mitochondrial biogenesis and apoptosis in skeletal muscleAyesha Saleem
School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada
Physiol Genomics 37:58-66. 2009..These data illustrate a novel role for p53 in maintaining mitochondrial biogenesis, apoptosis, and performance in skeletal muscle...
- Early adaptations to training: upregulation of alpha-myosin heavy chain gene expressionKarolina Rafalski
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Med Sci Sports Exerc 39:75-82. 2007....
- Rats selectively bred for low aerobic capacity have reduced hepatic mitochondrial oxidative capacity and susceptibility to hepatic steatosis and injuryJohn P Thyfault
Harry S Truman Memorial VA Hospital, Research Service, Columbia, MO 65201, USA
J Physiol 587:1805-16. 2009..We provide novel evidence that selection for low intrinsic aerobic capacity causes reduced hepatic mitochondrial oxidative capacity that increases susceptibility to both hepatic steatosis and liver injury...
- Regular voluntary exercise reduces anxiety-related behaviour and impulsiveness in miceElke Binder
Section of Behavioral Phenotyping, Max Planck Institute of Psychiatry, Munich D 80804, Germany
Behav Brain Res 155:197-206. 2004..Thus, our observations fit into the concept that regular exercise strengthens endogenous stress coping mechanisms, thereby protecting the organism against the deleterious effects of stress...
- Congenic strains confirm aerobic running capacity quantitative trait loci on rat chromosome 16 and identify possible intermediate phenotypesJustin A Ways
Departments of Physiology, Pharmacology, Metabolism, and Cardiovascular Sciences, University of Toledo College of Medicine, Toledo, OH 43614, USA
Physiol Genomics 29:91-7. 2007..While this colocalization of QTLs may be coincidental, it is also possible that these differences in energy balance may be associated with the superior running performance of COP.DA(chr 16) consomic rats...
- Chronic hypoxia attenuates resting and exercise-induced VEGF, flt-1, and flk-1 mRNA levels in skeletal muscleI M Olfert
Department of Physiology and Pharmacology, Loma Linda University, Loma Linda, California 92350, USA
J Appl Physiol 90:1532-8. 2001..These findings may provide an explanation for the lack of mammalian skeletal muscle angiogenesis that is observed after chronic hypoxia...
- Exercise preconditioning reduces brain damage and inhibits TNF-alpha receptor expression after hypoxia/reoxygenation: an in vivo and in vitro studyYun Hong Ding
Department of Neurosurgery, The University of Texas Health Science Center at San Antonio, Mail Code 7843, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
Curr Neurovasc Res 3:263-71. 2006..Chronically increased TNF-alpha expression was also found to reduce TNFI and II responding to acute ischemia/reperfusion insult...
- The effect of physical exercise on the daily rhythm of platelet aggregation and body temperature in horsesGiuseppe Piccione
Department of Morphology, Biochemistry, Physiology and Animal Production, Laboratory of Veterinary Chronophysiology, Section of Veterinary Physiology, 98168 Messina, Italy
Vet J 176:216-20. 2008..The results could be interpreted as indicating that physical exercise has an influence on the daily rhythm of platelet aggregation in horses...
- Development Stress, Exercise, and Vulnerability to Neuronal InjuryMichael J Zigmond; Fiscal Year: 2010....
- Veterinary Comparative Respiratory Society 2008 SymposiumMichael Davis; Fiscal Year: 2008..This symposium will review the current knowledge and practical challenges of these models in order to make them more accessible to the biomedical research community. [unreadable] [unreadable] [unreadable]..
- ANIMAL MODELS OF COLD AIR-INDUCED AIRWAY DISEASEMichael Davis; Fiscal Year: 2004..The investigators will use these same measurements to determine the changes in pulmonary mechanics and airway inflammation in dogs that perform repeated exercise in frigid environments. ..
- NCRR Training Grant for Veterinary Students in ResearchMichael Davis; Fiscal Year: 2006..Over a three-year period this program will contribute nine comparative medical scientists with veterinary medical degrees who are well trained in animal-oriented, hypothesis-based research. [unreadable] [unreadable]..
- Voluntary Exercise Therapy after Traumatic Brain InjuryGRACE GRIESBACH; Fiscal Year: 2006..In order to address these specific aims, I will utilize the lateral fluid-percussion injury model in rats and voluntary running wheel exposure. Protein, gene, histological and behavioral studies will be conducted. ..
- eNOS: Metabolism & Vascular Biology in Health & DiseaseM Laughlin; Fiscal Year: 2007..The strong group of investigators submitting this application is uniquely qualified and prepared to accomplish these goals. ..
- MECHANICAL VENTILATION AND RESPIRATORY MUSCLESScott Powers; Fiscal Year: 2004..The long-term goal of our experiments is to provide the knowledge required to develop clinical strategies to oppose the deleterious effects of MV on respiratory muscles. ..
- Pulse Doppler Ultrasound Imaging SystemJOAN CARROLL; Fiscal Year: 2004..abstract_text> ..
- SYSTOLIC CARDIAC FUNCTION IN OBESITY AND EXERCISEJOAN CARROLL; Fiscal Year: 2004..Because such a large segment of the American population is overweight or obese, the knowledge and insight gained from these studies can have far-reaching effects. ..
- Physical Activity, Aging and Immune FunctionJeffrey Woods; Fiscal Year: 2005..In addition, the biobehavioral approach inherent in our aims will allow us to determine the complexity of the relationship between exercise and immune function. ..
- Exercise, Antioxidants, and I-R InjuryScott Powers; Fiscal Year: 2006..abstract_text> ..
- Dietary Omega-3 Fatty Acids and Sudden Cardiac DeathGEORGE EDWARD BILLMAN; Fiscal Year: 2010..This project will also determine the effectiveness of fish oil supplements in reducing sudden death due to a lethal abnormal heart rhythm after a heart attack. ..
- Proteome Mapping of Heart Failure in AgingMARVIN BOLUYT; Fiscal Year: 2005..Identification of proteins involved in aldosterone signaling will lead to the development of new hypotheses for future grant proposals addressing their roles in the development of heart failure in the elderly. ..
- Effect of Daily Exercise on Cardiac Autonomic RegulationGEORGE BILLMAN; Fiscal Year: 2005..Ventricular contractile responses to Beta1- and Beta2-adrenoceptor stimulation will be examined in vivo by echocardiography and in vitro by single cell fluorescence microscopy/video edge detection. ..
- SYSTOLIC CARDIAC FUNCTION IN OBESITY AND EXERCISEJOAN CARROLL; Fiscal Year: 2004..Because such a large segment of the American population is overweight or obese, knowledge and insight gained from these studies can have far-reaching effects. ..
- PHYSICAL ACTIVITY, ANTIDEPRESSANTS AND BDNF INDUCTIONAmelia Russo Neustadt; Fiscal Year: 2008..Knowledge about the mechanisms responsible for the enhancement of antidepressant response will inform the development of novel, more efficacious and rapid treatments. ..
- Mechanical Ventilation and Diaphragmatic Oxidant InjuryScott Powers; Fiscal Year: 2008..abstract_text> ..
- Combination Therapy for Chronic Stroke-Induced ImpairmentJ Leigh Leasure; Fiscal Year: 2008..The proposed experiment will test a potential treatment for chronic stroke-related impairment in the aged brain. [unreadable] [unreadable] [unreadable]..
- Dorsomedial Hypothalamic Signaling Pathways and Energy BalanceSheng Bi; Fiscal Year: 2010..Overall, the elucidation of the actions of these DMH peptide systems in feeding and body weight control would significantly advance our understanding of the role of this hypothalamic nucleus in maintaining energy homeostasis. ..
- Sympathetic Control in Heart Failure: A Role of StatinsIrving H Zucker; Fiscal Year: 2010..We will determine if a class of drugs called statins has the potential for reducing some of the deleterious consequences of compensatory mechanisms in the heart failure state. ..
- CHRONIC CORONARY OCCLUSION, EXERCISE TRAINING AND NOCristine L Heaps; Fiscal Year: 2010....
- Mechanisms to Induce Islet ProliferationPATRICK FUEGER; Fiscal Year: 2008..This award will be an instrumental component towards my ultimate goal of pursuing a career in diabetes research. [unreadable] [unreadable]..
- Activity-Induced Recovery Following Brain TraumaFernando Gomez Pinilla; Fiscal Year: 2008..Therefore, the unique aspect of our proposal is to evaluate experience as a modulator of neuronal plasticity that can be used to enhance functional recovery following TBI. ..
- CANINE AS AN ANIMAL MODEL OF HUMAN AGINGCarl Cotman; Fiscal Year: 2005..Overall, this project should provide unique insight into the role of oxidative damage and subsequent molecular cascades on the progression of brain aging and cognitive decline. ..
- Changes in Functional Status Across Therapy for Primary GliomaLee Jones; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Effects of Myostatin Deficiency on Bone StrengthMark Hamrick; Fiscal Year: 2007..abstract_text> ..
- Regulation of Oxidative Stress in the mdx DiaphragmJOHN LAWLER; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..
- Brain Aging & Gene Expression Patterns Using MicroarraysCarl Cotman; Fiscal Year: 2007..Once an initial primary paper is published the overall data will be made available to the field via NACC for various investigators to analyze for the testing their own hypotheses. ..
- Physical Activity Measurement in Older AdultsLisa Colbert; Fiscal Year: 2007..This methodology can then be incorporated into future studies examining the associations between doses of physical activity and various health outcomes. [unreadable] [unreadable]..
- Genetic Analysis of Bone Structure and StrengthCharles Turner; Fiscal Year: 2008..abstract_text> ..
- Origins of Binaural Processing in VertebratesRichard Fay; Fiscal Year: 2008..abstract_text> ..
- Sound Source Segregation and DeterminationRichard Fay; Fiscal Year: 2007..We will focus on understanding the dimensions of neural activity that the brain could use in segregating and integrating simultaneous acoustic components from one or more sources. [unreadable] [unreadable]..
- ABeta Immunization in AgingCarl Cotman; Fiscal Year: 2005..Overall, this project should provide unique insight into the efficacy of immunization with fibrillar Abeta and have direct implications for the design of human clinical trials. ..
- Effect of Age on Exercise-Induced CardioprotectionJOSEPH STARNES; Fiscal Year: 2003..The results of this Aim will provide key direction for the effective design of further comprehensive studies using inhibitors and/or activators of specific proteins or signaling pathways. ..
- MUSCLE CAPILLARY GEOMETRY, FLOW, AND OXYGEN TRANSFERDavid Poole; Fiscal Year: 2001....
- ACTIVITY DEPENDENT PLASTICITY IN THE AGING BRAINCarl Cotman; Fiscal Year: 2004..Data from the proposed experiments will provide an initial characterization of how a simple, widely practiced activity-exercise-regulates expression of BDNF, a molecule increasingly recognized for its critical role in brain function. ..
- Dorsomedial Hypothalamic Pathways and Energy BalanceSheng Bi; Fiscal Year: 2005..Together, these neurochemical and functional demonstrations will provide a clear view of the role of the DMH in energy balance ..
- Vascular tone and blood pressure control during exerciseJohn Buckwalter; Fiscal Year: 2005..This is an issue of fundamental importance that may have important implications for individuals with peripheral vascular disease. ..
- PHYSICAL ACTIVITY INDUCES NEUROTROPHIC FACTORSFernando Gomez Pinilla; Fiscal Year: 2002..Thirdly, the PI will determine whether locomotor deficit caused by degeneration of large muscle afferents (by using high doses of pyridoxine) can be countered by daily locomotion induction of neurotrophins. ..
- NEURAL MECHANISMS OF SOUND SOURCE IN VERTEBRATESRichard Fay; Fiscal Year: 2002..These results will help in the development and evaluation of animal models for human hearing and help establish the comparative and evolutionary contexts within which the human sense of hearing can be better understood. ..
- APOPTOTIC INSULTS SUPPRESS MARKERS NEURONAL PLASTICITYCarl Cotman; Fiscal Year: 2004..Together, these experiments may provide support for a mechanism (s) accounting for some of the well-known changes in brain aging and AD, including reduced activity dependent plasticity, synaptic integrity and neuronal survival. ..
- MECHANISMS OF PATHOLOGICAL NEURITIC & SOMAL DEGENERATIONCarl Cotman; Fiscal Year: 2002..The studies proposed in this application will provide new and basic biological findings potentially relevant to a wide array of normal and pathological events involving synaptic remodeling and neurite degeneration. ..
- NEUROTROPHIN REGULATION IN THE SPINAL CORDFernando Gomez Pinilla; Fiscal Year: 2003..abstract_text> ..
- DEFECTIVE ALPHA, ADRENERGIC SIGNALING IN SENESCENT RATDONNA KORZICK; Fiscal Year: 2003..Environment: The environment surrounding Dr. Korzick at the University of Missouri is one marked by a commitment to research and academic scholarship with major strengths in cardiovascular sciences. ..
- Instruments for measuring physical activityJames Levine; Fiscal Year: 2008..This should allow us to better define the role of physical activity in health and disease. ..
- Stress, Heat-Shock Proteins, and Innate ImmunityMonika Fleshner; Fiscal Year: 2008..abstract_text> ..
- Extracellular Matrix Remodeling and Tissue MechanicsDENISE HOCKING; Fiscal Year: 2004....
- Cellular Mechanisms in the Pathogenesis of FHCJIL TARDIFF; Fiscal Year: 2006..A better understanding of these processes may well lead to specific therapeutic interventions which could alter the malignant natural history of this disorder. ..
- Control of ATP Producing Pathways in Skeletal MuscleBrandon Walsh; Fiscal Year: 2005..determine the role of metabolic channeling in setting the onset kinetics of oxidative phosphorylation, and 3.) determine the intracellular PO2 at which respiration becomes O2 dependent. ..
- Skeletal Muscle Microcirculation in Obese Zucker RatsJefferson Frisbee; Fiscal Year: 2009..abstract_text> ..
- Endothelial Deformation and Coronary Arteriolar FunctionDong Sun; Fiscal Year: 2006....
- PET Behavioral Brain Mapping In Freely Moving AnimalsDANIEL HOLSCHNEIDER; Fiscal Year: 2006..Such knowledge may provide the basis of an improved integration of a functional brain anatomy in the context of mental disorders. ..
- Neurobiology of Musculoskeletal PainKathleen Sluka; Fiscal Year: 2005..These proposed studies are intended to help in the understanding and thus potential treatment of chronic muscle pain including such conditions as fibromyalgia, myofascial pain and low back pain. ..
- Low Carbohydrate Diets: Feeding and Endocrine SignalingTimothy Moran; Fiscal Year: 2006..abstract_text> ..
- Protein Tyrosine Phosphatase 1B and Insulin ActionBarbara Kahn; Fiscal Year: 2005..Our goal is to find new therapeutic targets to reduce insulin resistance and prevent or ameliorate type 2 diabetes. ..
- Dystrophic Cardiomyopathies in mdxDeWayne Townsend; Fiscal Year: 2006..unreadable] [unreadable]..
- Developmental Stress and Vulnerability to Brain InjuryMichael Zigmond; Fiscal Year: 2004..Moreover, the methods and reagents that we develop will be made available to others in the field. ..
- PRO-Surveyor: Device for Capturing Patient Reported Outcome Data in ChildrenNadine Connor; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
- Mechanisms of Arrhythmia Suppression by Exercise Traini*HEIDI LUJAN; Fiscal Year: 2005..This experience will provide for me the research skill to develop into an independent investigator and the scientific foundation to obtain external funds at the national level. ..
- A Rapid Immunoassay for Detection of Yersinia PathogensJohn Glass; Fiscal Year: 2002..Furthermore, this prototype assay will be reduced to a production model, validated for regulatory approval, and finalized for manufacture through a joint venture partner. ..
- Physiological Signals to MCT ExpressionGeorge Brooks; Fiscal Year: 2008..Aim 3 studies will involve comparisons of the levels of muscle MCT pre-mRNAs, mRNAs and protein levels. We have the tools to achieve the stated aims. ..
- The Role of Microsatellite Instability in CancerHarold Garner; Fiscal Year: 2005..We will also (Aim 3) investigate the effects of these mutations identified in Aim 2 on splicing by correlating them with the results of a quantitative global survey of splicing isoforms. ..
- ADAPTIVE BEHAVIOR AND BRAIN MONOAMINESMichael Zigmond; Fiscal Year: 2002..The longer-term objectives of this project are to provide new insights into the basic neurobiology of LC neurons and the psychopathology that develops from chronic stress. ..
- TRAINING FACULTY TO TEACH SURVIVAL SKILLS AND ETHICSMichael Zigmond; Fiscal Year: 2005..Efforts will be made to promote diversity with regard to the demographics of both the workshop participants and those they serve. Instruction will be provided by the PI's together with a highly qualified group of trainers. ..
- NEUROBIOLOGY OF CHRONIC MUSCLE PAINKathleen Sluka; Fiscal Year: 2003..These proposed studies will help in the understanding and thus potential treatment of chronic muscle pain, including such conditions as fibromyalgia, myofascial pain and low back pain. ..
- Failed rescue of old skeletal muscle from atrophyFrank Booth; Fiscal Year: 2004..Identifying the inappropriately expressed mRNAs associated with failed muscle regrowth of old muscles will permit a more scientifically-based growth factor rescue of old atrophied muscle. ..
- Role of ASIC3 in the etiology of fibromyalgiaKathleen A Sluka; Fiscal Year: 2010..These studies could lead to peripherally based therapeutic approaches to control pain without undesirable CMS (central nervous system) side effects, including gene therapy. ..
- Proteomics: Inactivity-induced muscle insulin resistanceFrank Booth; Fiscal Year: 2002..Outcomes of this proposal will better establish that healthy active skeletal muscles interact with other organ systems to prevent the metabolic disorders of type 2 diabetes, atherosclerosis, and obesity. ..
- Regulation of skeletal alpha actin expression during mu*Espen Spangenburg; Fiscal Year: 2008..The overall goal is to determine the role IGF-I may have in activating transcriptional activity during muscle regrowth. ..
- STRUCTURAL DETERMINANTS OF NEUROENDOCRINE RECEPTORSCarrie Haskell Luevano; Fiscal Year: 2008..abstract_text> ..
- ACTIONS OF OPIATE DRUGS--DIETARY MODULATIONROBIN KANAREK; Fiscal Year: 2002....
- Human Melanocortin-4 Receptor PolymorphismsCarrie Haskell Luevano; Fiscal Year: 2007..Understanding obesity related mechanisms may ultimately result in therapeutic agents to prevent or treat the diseases associated with over eating. ..