Genomes and Genes
Summary: Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.
Publications380 found, 100 shown here
- Are animal models relevant to key aspects of human parturition?Bryan F Mitchell
Department of Obstetrics and Gynecology, Heritage Medical Research Centre, University of Alberta, Edmonton, Alberta, Canada
Am J Physiol Regul Integr Comp Physiol 297:R525-45. 2009..The scientific literature, largely derived from rodent animal models, suggests two major mechanisms regulating the timing of parturition: the withdrawal of the steroid hormone ..
- Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) GroupRinaldo Bellomo
Department of Intensive Care and Medicine, Austin Health, Melbourne, Australia
Crit Care 8:R204-12. 2004..Similarly, strong debate exists on the validity and clinical relevance of animal models of ARF; on choices of fluid management and of end-points for trials of new interventions in this field; and on ..
- The benefits and limitations of animal models for translational research in neurodegenerative diseasesMathias Jucker
Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
Nat Med 16:1210-4. 2010..This commentary summarizes current models and highlights key questions we should be asking about animal models, as well as questions that cannot be answered with the current models.
- Role of angiogenesis in human tumor dormancy: animal models of the angiogenic switchGeorge N Naumov
Department of Surgery, Harvard Medical School, Boston, Massachusetts, USA
Cell Cycle 5:1779-87. 2006..Although clinically important, the biology of human tumor dormancy is poorly understood. The development of animal models which recapitulate the clinically observed timing and proportion of dormant tumors which switch to the ..
- Iron homeostasis: insights from genetics and animal modelsN C Andrews
Howard Hughes Medical Institute, Division of Hematology Oncology, Children s Hospital, Department of Pediatrics, Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
Nat Rev Genet 1:208-17. 2000..Complementing the genomic strategy, targeted mutagenesis in mice has produced new models of human iron diseases. The animal models described in this review offer valuable tools for investigating iron homeostasis in vivo.
- Quantitative comparison of the sensitivity of detection of fluorescent and bioluminescent reporters in animal modelsTamara Troy
Xenogen Corporation, USA
Mol Imaging 3:9-23. 2004..The use of blue-shifted excitation filters is explored as a method to subtract out tissue autofluorescence and improve the sensitivity of fluorescent imaging...
- Comparative aspects of lipid metabolism: impact on contemporary research and use of animal modelsWerner G Bergen
Program in Cellular and Molecular Biosciences, Department of Animal Sciences, Auburn University, AL 36849, USA
J Nutr 135:2499-502. 2005..of lipid metabolism, cardiovascular function, endocrine function, and dyslipidemia states utilizing various animal models and cell culture systems...
- The design and use of animal models for translational research in bone tissue engineering and regenerative medicineGeorge F Muschler
Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
Tissue Eng Part B Rev 16:123-45. 2010This review provides an overview of animal models for the evaluation, comparison, and systematic optimization of tissue engineering and regenerative medicine strategies related to bone tissue...
- Oxygen distribution and consumption within the retina in vascularised and avascular retinas and in animal models of retinal diseaseD Y Yu
Centre for Ophthalmology and Visual Science, Lions Eye Institute, The University of Western Australia, 2 Verdun Street, WA 6009, Nedlands, Australia
Prog Retin Eye Res 20:175-208. 2001..We examine the effect of acute and chronic occlusion of the retinal vasculature, and explore the feasibility of meeting the oxygen needs of the ischemic retina from the choroid. (ABSTRACT TRUNCATED)..
- The NGF saga: from animal models of psychosocial stress to stress-related psychopathologyFrancesca Cirulli
Section of Behavioural Neurosciences, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità Rome, Viale Regina Elena 299, I 00161 Roma, Italy
Front Neuroendocrinol 30:379-95. 2009....
- High-throughput screening and small animal models, where are we?Jean Giacomotto
Universite Claude Bernard Lyon, Villeurbanne, France
Br J Pharmacol 160:204-16. 2010..Moreover, most of the hits generated during screenings turn out to be invalid after further testing in animal models. To by-pass these limitations, efforts are now being made to screen chemical libraries on whole animals...
- FOXO animal models reveal a variety of diverse roles for FOXO transcription factorsK C Arden
Department of Medicine, Ludwig Institute for Cancer Research, University of California San Diego School of Medicine, La Jolla, CA 92093 0660, USA
Oncogene 27:2345-50. 2008..b>Animal models have proved to be invaluable tools in furthering our understanding of the role of particular genes in complex ..
- Physiological roles of MKK4 and MKK7: insights from animal modelsXin Wang
Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
Biochim Biophys Acta 1773:1349-57. 2007..For example, whereas MKK4 can activate p38 MAPK, MKK7 functions as a specific activator of JNK. Here we summarize the studies that have shed light on the mechanism of activation of MKK4 and MKK7 and on their physiological functions...
- The role of alpha-synuclein in Parkinson's disease: insights from animal modelsEleonora Maries
Department of Neuroscience, The Chicago Medical School, 3333 Green Bay Road, N Chicago, Illinois 60064, USA
Nat Rev Neurosci 4:727-38. 2003
- Animal models of wound healing: utility in transgenic miceRobert C Fang
Division of Plastic and Reconstructive Surgery, Department of Surgery, Northwestern University Feinberg School of Medicine, 675 N St Clair Street, Chicago, IL 60611, USA
J Biomater Sci Polym Ed 19:989-1005. 2008..A battery of standard and impaired wound healing models, when used in a systematic and combinatorial fashion, should yield significant contributions to wound healing research...
- Removing obstacles in neuroscience drug discovery: the future path for animal modelsAthina Markou
Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA 92093 0603, USA
Neuropsychopharmacology 34:74-89. 2009..To address these issues, this review critically discusses the traditional role of animal models in drug discovery, the difficulties encountered, and the reasons why this approach has led to suboptimal ..
- Surgical animal models of heart failure related to coronary heart diseaseRainer Klocke
Department of Cardiology and Angiology, University Hospital, University of Munster, Munster, Germany
Cardiovasc Res 74:29-38. 2007..in the pathogenesis of coronary heart disease-related heart failure and to develop therapies, appropriate animal models are indispensable...
- Animal models of working memory: insights for targeting cognitive dysfunction in schizophreniaStacy A Castner
Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
Psychopharmacology (Berl) 174:111-25. 2004..Prefrontal dysfunction in schizophrenia has been linked to altered dopaminergic and glutamatergic transmission. However, to date, antipsychotics provide no substantial relief from the debilitating cognitive consequences of this disease...
- Regulation of protein metabolism by insulin: value of different approaches and animal modelsSophie Tesseraud
UR83 Recherches Avicoles, INRA Tours, Nouzilly, France
Domest Anim Endocrinol 33:123-42. 2007..of the activation of intracellular kinases involved in insulin signaling, in addition to the use of different animal models in a comparative physiology process, provide better understanding of the potential regulation of protein ..
- Animal models for atrial fibrillation: clinical insights and scientific opportunitiesKunihiro Nishida
Department of Medicine, Montreal Heart Institute, Universite de Montreal, Montreal, Montreal, Quebec, Canada
Europace 12:160-72. 2010Atrial fibrillation (AF) is the most common arrhythmia in clinical practice. A variety of animal models have been used to study the pathophysiology of AF, including molecular basis, ion-current determinants, anatomical features, and ..
- Laser photobiomodulation of wound healing: a review of experimental studies in mouse and rat animal modelsPhilip V Peplow
Department of Anatomy and Structural Biology, University of Otago, Dunedin, New Zealand
Photomed Laser Surg 28:291-325. 2010..This investigation reviewed experimental studies of laser irradiation of wound healing in mice and rats published from 2003 to August 2008, respectively, to assess putative stimulatory effects of this treatment...
- Animal models to study environmental epigeneticsCheryl S Rosenfeld
Department of Biomedical Sciences, University of Missouri, Christopher S Bond Life Sciences Center, 1201 East Rollins Rd, Columbia, MO 65211, USA
Biol Reprod 82:473-88. 2010..Various animal models have been described, most notably the agouti viable yellow (A(vy)) and axin 1 fused (Axin1(Fu)) mice, which ..
- In vivo confocal imaging of the retina in animal models using scanning laser ophthalmoscopyMathias W Seeliger
Retinal Diagnostics Research Group, Tuebingen, Germany
Vision Res 45:3512-9. 2005..In animal models, a further enhancement in specificity can be obtained by GFP expression under control of tissue-specific ..
- Human listeriosis and animal modelsMarc Lecuit
Avenir Group INSERM U604 Microbial Interactions with Host Barriers, Bacteria Cell Interactions Unit, Department of Cell Biology and Infection, Institut Pasteur, 25 rue du Dr Roux, 75015 Paris, France
Microbes Infect 9:1216-25. 2007..Finally, we present some of the critical determinants for the choice of an appropriate animal model to study human listeriosis...
- Role of the GH/IGF-1 axis in lifespan and healthspan: lessons from animal modelsDarlene E Berryman
School of Human and Consumer Sciences, College of Health and Human Services, Ohio University, Athens, OH 45701, United States
Growth Horm IGF Res 18:455-71. 2008b>Animal models are fundamentally important in our quest to understand the genetic, epigenetic, and environmental factors that contribute to human aging...
- Arterial calcification: a review of mechanisms, animal models, and the prospects for therapyR Wallin
Section of Rheumatology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA
Med Res Rev 21:274-301. 2001..vitamin D, nicotine, and warfarin, alone or in various combinations, produce arterial calcification in animal models. MGP has recently been discovered to be an inhibitor of bone morphogenetic protein-2, the principal osteogenic ..
- Animal models for the preclinical evaluation of candidate influenza vaccinesRogier Bodewes
Department of Virology, Erasmus Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
Expert Rev Vaccines 9:59-72. 2010..In this review, we discuss animal models that are used for the preclinical evaluation of novel candidate influenza vaccines...
- Animal model pharmacokinetics and pharmacodynamics: a critical reviewD Andes
University of Wisconsin, 600 Highland Avenue, Room H4 572, Madison, USA
Int J Antimicrob Agents 19:261-8. 2002..However, the magnitude of the target required for bacteriological efficacy is relatively similar for various sites of infection, various pathogens and various drugs within the same class, provided free drug levels are used...
- The versatile worm: genetic and genomic resources for Caenorhabditis elegans researchIgor Antoshechkin
Division of Biology 156 29, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA
Nat Rev Genet 8:518-32. 2007..We also hope that it will be helpful in identifying new research opportunities and will promote the development of additional resources...
- Pathophysiology of the blood-brain barrier: animal models and methodsBrian T Hawkins
Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Curr Top Dev Biol 80:277-309. 2008..BBB dysfunction is a complication of neurodegenerative disease and brain injury. Studies on animal models have shown that diseases of the periphery, such as diabetes and inflammatory pain, have deleterious effects on ..
- Report of an NIAID workshop on dengue animal modelsM Cristina Cassetti
National Institute of Allergy and Infectious Diseases, 6610 Rockledge Drive, Bethesda, MD, USA
Vaccine 28:4229-34. 2010..One of the main obstacles to the development of countermeasures has been the lack of good animal models that recapitulate dengue pathogenesis in humans and reliably predict the safety and efficacy of ..
- A robust animal model of state anxiety: fear-potentiated behaviour in the elevated plus-mazeS Mechiel Korte
ID Lelystad, Institute for Animal Science and Health, Edelhertweg 15, P O Box 65, The Netherlands
Eur J Pharmacol 463:163-75. 2003..The use of fear-potentiated plus-maze behaviour has several advantages as compared to more traditional animal models of anxiety...
- Mitochondrial function in vivo evaluated by NADH fluorescence: from animal models to human studiesAvraham Mayevsky
The Mina and Everard Goodman Faculty of Life Sciences and The Leslie and Susan Gonda Multidisciplinary Brain Research Center, Bar Ilan Univ, Ramat Gan 52900, Israel
Am J Physiol Cell Physiol 292:C615-40. 2007..This type of monitoring in animal models as well as in patients provides real-time data that can help interpret experimental results or optimize ..
- Are animal models predictive for humans?Niall Shanks
Americans for Medical Advancement, 2251 Refugio Rd Goleta, CA 93117, USA
Philos Ethics Humanit Med 4:2. 2009..The focus of this essay is the scientific term predict and whether there is credible evidence that animal models, especially in toxicology and pathophysiology, can be used to predict human outcomes...
- Evidence for the usefulness of in vitro dialyzability, Caco-2 cell models, animal models, and algorithms to predict zinc bioavailability in humansChristine Hotz
Centro de Investigación en Nutrición y Salud, Instituto Nacional de Salud Publica, Av Universidad No 655, Sta Ma Ahuacatitlan, Cuernavaca, Morelos CP 62508, Mexico
Int J Vitam Nutr Res 75:423-35. 2005..As a result, several experimental models including animal models, in vitro dialyzability models, and Caco-2 cells, have been used to study these factors and estimate their ..
- Reward and the serotonergic systemG S Kranz
Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
Neuroscience 166:1023-35. 2010..This review provides an argument for serotonin as a fundamental mediator of emotional, motivational and cognitive aspects of reward representation, which makes it possibly as important as dopamine for reward processing...
- Amnionless function is required for cubilin brush-border expression and intrinsic factor-cobalamin (vitamin B12) absorption in vivoQianchuan He
Department of Microbiology and Molecular Genetics, College of Veterinary Medicine, Michigan State University, East Lansing, MI, USA
Blood 106:1447-53. 2005..Characterization of canine AMN mutations that cause I-GS establishes the canine model as an ortholog of the human disorder well suited to studies of AMN function and coevolution with cubilin...
- Probiotic modulation of symbiotic gut microbial-host metabolic interactions in a humanized microbiome mouse modelFrancois Pierre J Martin
Department of Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics, Faculty of Medicine, Imperial College London, London, UK
Mol Syst Biol 4:157. 2008....
- Animal models in research on retinal degenerations: past progress and future hopeGerald J Chader
The Foundation Fighting Blindness, 11435 Cronhill Dr, Owings Mills, MD 21117, USA
Vision Res 42:393-9. 2002..However, some have other degenerative conditions such as retinitis pigmentosa, Leber congenital amaurosis or wet AMD and can suffer from severe vision loss or total blindness...
- Brain uptake and metabolism of ketone bodies in animal modelsAstrid Nehlig
INSERM U 405, Faculty of Medicine, 11, rue Humann, 67085 Strasbourg Cedex, France
Prostaglandins Leukot Essent Fatty Acids 70:265-75. 2004....
- Spontaneous and genetically engineered animal models; use in preclinical cancer drug developmentK Hansen
Comparative Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Rockville, Maryland, USA
Eur J Cancer 40:858-80. 2004..Examples of their successful use and an outline of their relative strengths and weaknesses will be provided...
- Animal models of steatosisA Koteish
Johns Hopkins University, 912 Ross Bldg, 720 Rutland Street, Baltimore, MD 21205, USA
Semin Liver Dis 21:89-104. 2001....
- Dynamic contribution of nestin-expressing stem cells to adult neurogenesisDiane C Lagace
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
J Neurosci 27:12623-9. 2007....
- Conjunctiva-associated lymphoid tissue - current knowledge, animal models and experimental prospectsPhilipp Steven
Department of Ophthalmology, University Medical Center Schleswig Holstein, Campus Luebeck, Luebeck, Germany
Ophthalmic Res 42:2-8. 2009..An update is given on CALT animal models and on functional studies on the transepithelial transport of microorganisms and antigenic substances by ..
- Design and statistical methods in studies using animal models of developmentMichael F W Festing
ILAR J 47:5-14. 2006..Different strains may develop at different rates and respond differently to experimental treatments...
- Animal models of tuberculosisU D Gupta
Central JALMA Institute for Leprosy and other Mycobacterial Disease ICMR, Tajganj, Agra 282001, India
Tuberculosis (Edinb) 85:277-93. 2005..As all existing animal models fail to mimic the human disease perfectly, efforts should be focused on the development of the non-human ..
- The pig eye as a novel model of glaucomaJavier Ruiz-Ederra
Department of Cellular Biology, Faculty of Medicine, University of the Basque Country, E 48940 Leioa, Vizcaya, Spain
Exp Eye Res 81:561-9. 2005..On the basis of this study, the pig retina may be considered as a suitable model for glaucoma-related studies, based on its similarity with human and on its affordability...
- Immunomodulatory properties of conjugated linoleic acidMarianne O'Shea
Loders Croklaan, Lipid Nutrition, Channahon, IL 60410, USA
Am J Clin Nutr 79:1199S-1206S. 2004In vitro studies of the use of immune cells and animal models demonstrate that conjugated linoleic acid (CLA), a lipid, modulates immune function...
- Lipoprotein(a) as a risk factor for atherosclerosis and thrombosis: mechanistic insights from animal modelsMichael B Boffa
Department of Biochemistry, Queen s University, Kingston, Ontario, Canada
Clin Biochem 37:333-43. 2004..Moreover, an effective and well-tolerated regimen to lower Lp(a) levels has yet to be developed. The use of animal models holds great promise for resolving these questions...
- Are adolescents more vulnerable to drug addiction than adults? Evidence from animal modelsNicole L Schramm-Sapyta
Duke University, Durham, NC, USA
Psychopharmacology (Berl) 206:1-21. 2009..b>Animal models, in which age of onset can be tightly controlled, offer a platform for testing causality...
- The protective immune response against vaginal candidiasis: lessons learned from clinical studies and animal modelsPaul L Fidel
Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
Int Rev Immunol 21:515-48. 2002..albicans infections both from clinical studies and animal models. From these data, hypotheses are presented for what host defense mechanisms appear important for resistance/..
- Animal models as indicators of immunogenicity of therapeutic proteins in humansJ L Bussiere
Immunex Corp, Seattle, WA 98101, USA
Dev Biol (Basel) 112:135-9. 2003b>Animal models have not been able to predict the immunogenicity of therapeutic proteins in humans reliably. The main issue is that administration of a human protein in an animal species is likely to be immunogenic...
- Real-time monitoring of nuclear factor kappaB activity in cultured cells and in animal modelsChristian E Badr
Neuroscience Center, Department of Neurology, Massachusetts General Hospital, Charlestown, 02129, USA
Mol Imaging 8:278-90. 2009..This NF-kappaB reporter system provides a powerful tool for monitoring NF-kappaB activity in real time in vitro and in vivo...
- Tissue mechanics, animal models, and pelvic organ prolapse: a reviewSteven D Abramowitch
Department of Bioengineering, Musculoskeletal Research Center, University of Pittsburgh, PA 15219, USA
Eur J Obstet Gynecol Reprod Biol 144:S146-58. 2009..Therefore, it is necessary to investigate the use of animal models and their importance in understanding how different risk factors affect the biomechanical properties of the ..
- Large animal models of hematopoietic stem cell gene therapyG D Trobridge
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
Gene Ther 17:939-48. 2010Large animal models have been instrumental in advancing hematopoietic stem cell (HSC) gene therapy...
- Use of animal models for space flight physiology studies, with special focus on the immune systemGerald Sonnenfeld
Department of Biological Sciences, Binghamton University, State University of New York, Binghamton, NY, USA
Gravit Space Biol Bull 18:31-5. 2005b>Animal models have been used to study the effects of space flight on physiological systems...
- Pathophysiology and animal models of schizophreniaGavin S Dawe
Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Clinical Research Centre, 10 Medical Drive, Singapore
Ann Acad Med Singapore 38:425-6. 2009b>Animal models of schizophrenia are important for research aimed at developing improved pharmacotherapies...
- Distribution and density of medium- and short-wavelength selective cones in the domestic pig retinaAnita Hendrickson
Department of Biological Structure, University of Washington, Seattle, WA, 98195, USA
Exp Eye Res 74:435-44. 2002..This tissue should be an excellent source for biochemical analysis of cone proteins, and for in vitro approaches to understanding cone survival factors...
- Epithelial ovarian cancer: focus on genetics and animal modelsWeiwei Shan
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Cell Cycle 8:731-5. 2009....
- Arteriogenesis depends on circulating monocytes and macrophage accumulation and is severely depressed in op/op miceCaroline E Bergmann
Research Group for Experimental and Clinical Arteriogenesis, Freiberg, Germany
J Leukoc Biol 80:59-65. 2006..This study provides additional evidence for the preeminent role of monocytes/macrophages during arteriogenesis in a genuine model of monocyte deficiency, i.e., without pharmacological intervention...
- Two faces of p53: aging and tumor suppressionFrancis Rodier
Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
Nucleic Acids Res 35:7475-84. 2007..Here, we discuss the role of p53 as a key regulator of the DNA damage responses, and discuss how p53 integrates the outcome of the DNA damage response to optimally balance tumor suppression and longevity...
- Animal models for studying homeopathy and high dilutions: conceptual critical reviewLeoni Villano Bonamin
Laboratory of Cellular and Molecular Biology, University Paulista, Brazil
Homeopathy 99:37-50. 2010This is a systematic review of the animal models used in studies of high dilutions...
- Ventilator-induced diaphragm dysfunction: the clinical relevance of animal modelsTheodoros Vassilakopoulos
Evangelismos Hospital, Critical Care Department, 45 47 Ipsilandou Str, 10675 Athens, Greece
Intensive Care Med 34:7-16. 2008..Partial (assisted) modes of ventilatory support should be used whenever feasible, since these modes attenuate the deleterious effects of mechanical ventilation on respiratory muscles...
- The HMG-CoA reductase inhibitor atorvastatin prevents atrial fibrillation by inhibiting inflammation in a canine sterile pericarditis modelKoichiro Kumagai
School of Internal Medicine, Department of Cardiology, Fukuoka University Hospital, 7 45 1, Nanakuma, Jonan, Fukuoka 814 0180, Japan
Cardiovasc Res 62:105-11. 2004..Statins reduce C-reactive protein (CRP) levels. However, the effect of statin on atrial fibrillation (AF) is unclear. The purpose of the present study was to evaluate the effect of statin on AF in a canine sterile pericarditis model...
- Stable embryonic stem cell lines in rabbits: potential small animal models for human researchArata Honda
RIKEN BioResource Centre, National Institute of Biomedical Innovation, Tsukuba, Japan
Reprod Biomed Online 17:706-15. 2008..Thus, rabbit ES cells can be added to the list of stable mammalian ES cells, enabling the rabbit to be used as a small animal model for the study of human cell transplantation therapy...
- Arteriogenesis is associated with an induction of the cardiac ankyrin repeat protein (carp)Kerstin Boengler
Max Planck Institute for Physiological and Clinical Research, Department of Experimental Cardiology, Benekestr 2, D 61231 Bad Nauheim, Germany
Cardiovasc Res 59:573-81. 2003..Collateral artery growth (arteriogenesis) can be induced in rabbit and mice by occlusion of the femoral artery. We aimed to identify genes that are differentially expressed during arteriogenesis...
- Dietary restriction in DrosophilaLinda Partridge
UCL Centre for Research on Ageing, Department of Biology, University College London, London WC1E 6BT, UK
Mech Ageing Dev 126:938-50. 2005..This rapid mortality rate recovery provides a powerful framework within which to further investigate the mechanisms by which DR extends lifespan...
- The short-lived fish Nothobranchius furzeri as a new model system for aging studiesEva Terzibasi
Istituto di Neuroscienze del CNR, Pisa, Italy
Exp Gerontol 42:81-9. 2007..It is very close to the Japanese Medaka, and close to the pufferfishes and stickleback and might represent a very useful model for comparative genomics of aging...
- Effects of prebiotics on mineral metabolismK E Scholz-Ahrens
Institute of Physiology and Biochemistry of Nutrition, Federal Dairy Research Center, Kiel, Germany
Am J Clin Nutr 73:459S-464S. 2001....
- Large differences in aging phenotype between strains of the short-lived annual fish Nothobranchius furzeriEva Terzibasi
Istituto di Neuroscienze del CNR, Pisa, Italy
PLoS ONE 3:e3866. 2008..A laboratory inbred strain of the annual fish Nothobranchius furzeri shows exceptionally short life expectancy and accelerated expression of age markers. In this study, we analyze new wild-derived lines of this short-lived species...
- Pathologic evaluation of a spherical polyvinyl alcohol embolic agent in a porcine renal modelGary P Siskin
Institute for Vascular Health and Disease, Albany Medical College, MC 157, 47 New Scotland Avenue, Albany, New York 12208, USA
J Vasc Interv Radiol 14:89-98. 2003..To evaluate the effects of a spherical embolic agent consisting of polyvinyl alcohol (PVA) and to compare this agent with commercially available embolization agents...
- Lactobacillus paracasei normalizes muscle hypercontractility in a murine model of postinfective gut dysfunctionElena F Verdu
McMaster University, 1200 Main Street West, HSC 3N5C, Hamilton, Ontario, Canada
Gastroenterology 127:826-37. 2004..We tested whether probiotics influence persistent muscle hypercontractility in mice after recovery from infection with Trichinella spiralis and analyzed the underlying mechanisms...
- Animal models for spinal fusionInneke H Drespe
Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, PO Box 208071, New Haven, CT 06520 8071, USA
Spine J 5:209S-216S. 2005b>Animal models for spinal fusion are essential for preclinical testing of new fusion methods and adjuncts. They allow for control of individual variables and quantification of outcome measures. Model characteristics are considered...
- Swine in biomedical research: creating the building blocks of animal modelsLawrence Schook
University of Illinois, Institute for Genomic Biology, 382 ERML, 1201 W Gregory Avenue, Urbana, IL 61801, USA
Anim Biotechnol 16:183-90. 2005..Closing discussions focused on the need for future conferences at more frequent intervals to support interactions between the various disciplines. This was especially critical because of the global distribution of investigators...
- The role of Caenorhabditis elegans insulin-like signaling in the behavioral avoidance of pathogenic Bacillus thuringiensisMartin Hasshoff
Institute for Animal Evolution and Ecology, Westfalische Wilhelms University, Munster, Germany
FASEB J 21:1801-12. 2007....
- Skeletal tissue engineering-from in vitro studies to large animal modelsPieter Buma
Orthopaedic Research Laboratory, Department of Orthopaedics, University Medical Center Nijmegen, P O Box 9101, 6500 HB, Nijmegen, Netherlands
Biomaterials 25:1487-95. 2004..In this paper, we focus on the use of relatively new simple in vitro and in vivo models for hip revision surgery, segmental bone defect restoration and tumour surgery...
- Intestinal ischemia reperfusion injury and multisystem organ failureAgostino Pierro
Department of Paediatric Surgery, The Institute of Child Health and Great Ormond Street Hospital for Children NHS Trust, University College London, London, UK
Semin Pediatr Surg 13:11-7. 2004..Further studies are needed to establish whether therapeutic hypothermia is a useful intervention in the treatment of infants and children with intestinal injuries caused by ischemia and reperfusion...
- Evaluation of the role of nuclear factor-kappaB signaling in liver injury using genetic animal modelsTom Luedde
EMBL Mouse Biology Program, Monterotondo, Italy
J Gastroenterol Hepatol 21:S43-6. 2006..Herein is summarized briefly some recent findings concerning the role of NF-kappaB in different models of liver injury based on transgenic and knockout animal technology...
- Animal models of acute moderate hypoxia are associated with a down-regulation of CYP1A1, 1A2, 2B4, 2C5, and 2C16 and up-regulation of CYP3A6 and P-glycoprotein in liverCaroline Fradette
Department of Pharmacology, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada
Drug Metab Dispos 35:765-71. 2007..It is concluded that in vivo, hypoxia down-regulates rabbit hepatic CYP1A1, 1A2, 2B4, 2C5, and 2C16 and up-regulates CYP3A6. CYP3A11 and P-glycoprotein were up-regulated in the livers of hypoxic rats...
- Animal models of drug-resistant epilepsyWolfgang Loscher
Department of Pharmacology, Toxicology, and Pharmacy, School of Veterinary Medicine, Hanover, Germany
Novartis Found Symp 243:149-59; discussion 159-66, 180-5. 2002..We are currently studying the cellular mechanisms underlying the development of drug-resistant kindled seizures...
- Centrosome abnormalities, recurring deletions of chromosome 4, and genomic amplification of HER2/neu define mouse mammary gland adenocarcinomas induced by mutant HER2/neuCristina Montagna
Genetics Branch, Center for Cancer Research, National Cancer Institute NIH, Bldg 9, Rm 1N105, 9 Memorial Drive, Bethesda, MD 20892, USA
Oncogene 21:890-8. 2002..It is likely that this region contains putative tumor suppressor genes whose inactivation is required for tumor formation in this model of human breast cancer...
- Fetal hypoxia insults and patterns of brain injury: insights from animal modelsAlistair Jan Gunn
Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, 85 Park Road, Grafton, Auckland 1023, New Zealand
Clin Perinatol 36:579-93. 2009....
- Functions of cathepsin K in bone resorption. Lessons from cathepsin K deficient miceP Saftig
Abteilung Biochemie II, Universitat Gottingen, Germany
Adv Exp Med Biol 477:293-303. 2000..Taken together the phenotype of cathepsin K knockout mice underlines the importance of this proteinase in bone remodelling...
- Biomechanical considerations of animal models used in tissue engineering of boneMichael A K Liebschner
Department of Bioengineering, Rice University, 6100 Main Street, Houston, TX 77005, USA
Biomaterials 25:1697-714. 2004..strategies into clinical therapeutic protocols requires extensive, preclinical experimentation in appropriate animal models. The ultimate success of any treatment strategy must be established in these animal models before clinical ..
- Animal models of ovarian cancerBarbara C Vanderhyden
Department of Cellular and Molecular Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, Canada K1H 8M5
Reprod Biol Endocrinol 1:67. 2003..b>Animal models which accurately represent the cellular and molecular changes associated with the initiation and progression ..
- Diet and agingMatthew D W Piper
UCL Institute of Healthy Ageing, University College London, London, WC1E 6BT, UK
Cell Metab 8:99-104. 2008..Here we discuss examples of diet/genotype interactions that show a more complex mechanistic view is required and that mild dietary modifications can dramatically change the interpretation of model organism aging studies...
- Animal models of cancer painCholawat Pacharinsak
Department of Comparative Medicine, Stanford University School ofMedicine, Stanford, CA, USA
Comp Med 58:220-33. 2008..However this situation has recently changed with the recent development of several novel animal models of cancer pain...
- Combined I-124 positron emission tomography/computed tomography imaging of NIS gene expression in animal models of stably transfected and intravenously transfected tumorDavid Dingli
Molecular Medicine Program, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Mol Imaging Biol 8:16-23. 2006..We evaluated the potential of I-124 positron emission tomography (PET)/computed tomography (CT) imaging in gene therapy animal models utilizing the sodium iodide symporter (NIS) and compared the findings to I-123 gamma camera imaging.
- Pegylated liposomal doxorubicin: proof of principle using preclinical animal models and pharmacokinetic studiesDavid M Vail
Animal Cancer Center, Colorado State University, Fort Collins, CO 80523 1620, USA
Semin Oncol 31:16-35. 2004..On the basis of pharmacokinetic and preclinical studies, PLD, either alone or as part of combination therapy, has potential applications to treat a variety of cancers...
- Drinks like a fish: zebra fish (Danio rerio) as a behavior genetic model to study alcohol effectsR Gerlai
Neuroscience Department, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA
Pharmacol Biochem Behav 67:773-82. 2000..We hope that our pilot work will facilitate the future development of behavioral tests and the use of zebra fish in the genetic analysis of the biological effects of drugs of abuse...
- Zebrafish and medaka: model organisms for a comparative developmental approach of brain asymmetryIskra A Signore
Laboratory of Experimental Ontogeny, Nucleus of Neural Morphogenesis, Anatomy and Developmental Biology Program, ICBM, Faculty of Medicine, University of Chile, Independencia 1027, Santiago, Chile
Philos Trans R Soc Lond B Biol Sci 364:991-1003. 2009..Together, these findings highlight the usefulness of zebrafish and medaka as comparative models to study the developmental mechanisms of epithalamic asymmetry in vertebrates...
- A systematic review and meta-analysis of the impact of omega-3 fatty acids on selected arrhythmia outcomes in animal modelsNirupa R Matthan
Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
Metabolism 54:1557-65. 2005..It is not known whether omega-3 fatty-acid supplementation has antiarrhythmic effects in other disease settings not related to ischemia...
- Statistical issues in the design and analysis of gene expression microarray studies of animal modelsLisa M McShane
Biometric Research Branch, National Cancer Institute, Bethesda, Maryland 20892, USA
J Mammary Gland Biol Neoplasia 8:359-74. 2003..studies is critical in order to draw valid and useful conclusions from expression profiling studies of animal models. In this paper, several aspects of study design are discussed, including the number of animals that need to be ..
- Transformations of selected carotenoids in plasma, liver, and ocular tissues of humans and in nonprimate animal modelsFrederick Khachik
Department of Chemistry and Biochemistry, Joint Institute for Food Safety and Applied Nutrition JIFSAN, University of Maryland, College Park, Maryland 20742, USA
Invest Ophthalmol Vis Sci 43:3383-92. 2002..Similarly, to characterize the carotenoid profiles in the eye tissues, plasma, and liver of quails and frogs to determine whether these can serve as appropriate nonprimate animal models for metabolic studies.
- Large animal models: baboons for trauma, shock, and sepsis studiesHeinz Redl
Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, A 1200 Vienna, Austria
Shock 24:88-93. 2005A few limited examples of large animal models are outlined, with the main emphasis on baboon models...
- Animal models of pain: progress and challengesJeffrey S Mogil
Department of Psychology and Alan Edwards Centre for Research on Pain, McGill University, Montreal, Quebec, Canada
Nat Rev Neurosci 10:283-94. 2009..of translational progress in the pain field, in which huge gains in basic science knowledge obtained using animal models have not led to the development of many new clinically effective compounds...
- Animal models of mitochondrial DNA transactions in disease and ageingMarcos T Oliveira
Department of Biochemistry and Molecular Biology, Center for Mitochondrial Science and Medicine, and Graduate Program in Genetics, Michigan State University, East Lansing, MI 48824 1319, USA
Exp Gerontol 45:489-502. 2010..Furthermore, the animal models recapitulate many phenotypes related to human ageing and a variety of different diseases, a feature that has ..
- Animal models of attention-deficit hyperactivity disorderEugen Davids
Department of Psychiatry and Neuroscience Program, Harvard Medical School, and Mailman Research Center, McLean Division of Massachusetts General Hospital, 115 Mill Street, Belmont, MA 02478 9106, USA
Brain Res Brain Res Rev 42:1-21. 2003..One of the most extensively evaluated animal models of ADHD is the spontaneously hypertensive rat...
- Comparisons of diets used in animal models of high-fat feedingCraig H Warden
Cell Metab 7:277. 2008
- Animal models of implantationKevin Y Lee
Department of Molecular and Cellular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030 3498, USA
Reproduction 128:679-95. 2004..Due to the impracticalities of studying implantation in humans, animal models are necessary to decipher the molecular and mechanical events of this process...
- Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responsesSusumu Nakae
Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, Japan
Immunity 17:375-87. 2002..Our findings indicate that IL-17 plays an important role in activating T cells in allergen-specific T cell-mediated immune responses...
- Discovery metabolite profiling of the prolyl peptidasesAlan Saghatelian; Fiscal Year: 2009..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
- Mice Humanized with Hepatocytes and iPS Cells from Patients with Metabolic DiseasStephen C Strom; Fiscal Year: 2010..For most, there are no small animal models that faithfully reproduce the human phenotype...
- Serpin Modulation of Inflammatory Vasculitis; Potential for Immunomodulatory TherALEXANDRA ROSE LUCAS; Fiscal Year: 2010..actions in atherosclerosis (Fig/s 2 &3), transplant vasculopathy, and collagen-induced arthritis in animal models. NSP is expressed by neurons, monocytes, and multiple organs, and is reported to reduce stroke volume in ..
- Anti-tumor properties of curcumin in oral cancers: role of thioredoxin reductaseSTEPHEN WILLIAM TUTTLE; Fiscal Year: 2010..plant polyphenolic antioxidant with potent chemopreventive and antintumorigenic properties in preclinical animal models and a demonstrated low toxicity profile in Phase I clinical trials Recent data demonstrate a covalent ..
- Identification of Genetic and Epigenetic Alterations in SpondyloarthritisTibor T Glant; Fiscal Year: 2013..b>Animal models are invaluable tools for understanding the mechanisms of human (autoimmune) disorders...
- Correction of glutathione deficiency for treatment of diabetic nephropathyPaolo Fanti; Fiscal Year: 2013..first step for the future design of more definitive clinical investigation and of mechanistic research in animal models of T2DM and diabetic nephropathy...
- Hypothalamic Orexin Role in Menopause-Associated Hot Flashes and Mood/Sleep DisruPHILIP LEE JOHNSON; Fiscal Year: 2013..of menopausal symptoms, which to our knowledge, has not been previously reported;4) I have developed novel animal models of hot flash vulnerability to test my hypotheses;5) I will apply pharmacology, acute gene and chronic ..
- Ligand Directed Transdermal siRNA Delivery to Improve Wound HealingDavid M Evans; Fiscal Year: 2012..Aim 3 will evaluate the multi- targeted siRNA cocktail formulation in young versus elderly mice in animal models of wound healing...
- Enhanced iron removal with peptide linked chelators targeted to ferritinElizabeth C Theil; Fiscal Year: 2010..Whether the peptide-DFO complex will increase iron removal from cultured cells, animal models or humans remains to be determined...
- Prevention of Acute Lung Injury by IL-6 activated STAT3Ana Moran; Fiscal Year: 2010..A molecular and cellular understanding of T/HS-induced apoptosis of AECs in pre-clinical animal models and the successful performance of the experiments outlined in this proposal will allow us to confirm and ..
- Antiphospholipid antibodies and lupus: new molecular targets for treatmentEmilio B Gonzalez; Fiscal Year: 2013..their antigen on various types of cells as a means to ameliorate aPL Abs-pathogenic effects in vitro and in animal models. These studies may help to devise new more specific and less harmful modalities than the anticoagulation or ..
- Development of a Nonpsychotropic Cannabinoid Agonist for the Treatment of SclerodRobert B Zurier; Fiscal Year: 2012..The proposed experiments will determine in animal models the efficacy and mechanisms of action responsible for the antifibrotic effects of ajulemic acid (AJA).
- Cystathionine beta synthase (CBS) and angiogenesisPriyabrata Mukherjee; Fiscal Year: 2013..b>Animal models of CBS deficiency exhibit endothelial dysfunction, impaired angiogenesis, atherosclerosis, thrombosis, ..
- Discovery of Small Molecule MBT Domain AntagonistsSTEPHEN VERNON FRYE; Fiscal Year: 2010..will permit biological hypotheses concerning chromatin-state to be tested with confidence in cell-based and animal models of human biology and disease...
- ROLE OF Rac AND REACTIVE OXYGEN SPECIES IN KAPOSI'S SARCOMA VIRAL ONCOGENESISEnrique A Mesri; Fiscal Year: 2013..Essential to this work is the creation of animal models of the disease...
- Sphingolipid Metabolism in Drosophila DevelopmentJulie D Saba; Fiscal Year: 2013..are to compare the biochemical and molecular events associated with SPL loss in Drosophila and murine cell and animal models, with the intent of developing a comprehensive understanding of how SPL functions in the context of muscle ..
- Response to and signals of caloric restriction and intermittent feeding regimensMARC KOPEL HELLERSTEIN; Fiscal Year: 2010DESCRIPTION (provided by applicant): Caloric restriction (CR) extends life-span and delays diseases in animal models. This remarkable observation has been difficult to translate into human health benefits, for two primary reasons...
- Lung Lysyl Oxidase Regulation by Metal Ion HomeostasisWande Li; Fiscal Year: 2013..binding proteins;and 4) to investigate biological consequences of Cd silencing of the LO gene in cell and animal models by examining effects of altered LO expression by Cd on substrate promoter activation and cell transformation ..
- Effect of PPARy Ligands on Alcohol-Induced Alveolar Macrophage Oxidative StressSamantha M Yeligar; Fiscal Year: 2013..Brown and Hart, she acquired additional expertise with numerous molecular biology techniques and with animal models of chronic alcohol ingestion...
- A Redox-active PARP Inhibitor for Lung TransplantationANDREW LURIE SALZMAN; Fiscal Year: 2012..At present there are no approved prophylactic measures. We are developing a novel drug that targets the basic mechanisms of this condition and will test this agent in two clinically-relevant animal models.
- Patient-Derived Stem Cells for Phosphoproteomic Profiling NeuropsychopathologyDieter A Wolf; Fiscal Year: 2011....
- Induction and maintenance of regulatory T cellsMitchell Kronenberg; Fiscal Year: 2013..They work in relevant animal models of infection and immune mediated diseases such as type I diabetes, colitis and asthma. In Project 1, led by Dr...
- Investigating Mechanism of Intracellular Rotational Transport with Optical TJeffrey N Anker; Fiscal Year: 2012..optically tracking MagMOONs in tissue phantoms we can also show feasibility for eventual in vivo detection in animal models with fewer tracer particles and localization of the particles in the lungs through endoscopy and transdermal X-..
- Iron, Metabolic Regulation and Type 2 Diabetes RiskDonald A McClain; Fiscal Year: 2013..We propose to study the mechanisms for these associations in animal models because it is crucial to understand the ramifications of altering body iron stores to ameliorate diabetes risk...
- Biology and Pathologies of Type V CollagenDaniel S Greenspan; Fiscal Year: 2013..Also proposed are studies in animal models, to test whether col(V) autioimmunity is causal in the pathogenesis of atherosclerosis, and whether induction ..
- Mitochondrial Dysfunction and Adipose Insulin ResistanceDavid A Bernlohr; Fiscal Year: 2013..we present new findings that demonstrate that the down regulation of GSTA4 is not merely a process observed in animal models of insulin resistance but also occurs selectively in obese, insulin resistant, but not obese, insulin ..
- DNA methylation of extracellular superoxide dismutase in pulmonary hypertensionEVA NOZIK GRAYCK; Fiscal Year: 2012..highly expressed SOD isoform in the vasculature under normal conditions, and EC-SOD expression is decreased in animal models of lung or vascular injury and several human diseases, including one study showing a decrease in EC-SOD ..
- VitC to Decrease Effects of Smoking in Pregnancy on Infant Lung Function-CCC-LeadCYNTHIA T MCEVOY; Fiscal Year: 2013..The success of this study is also supported by animal models showing the effectiveness of vitamin C to preserve pulmonary function and genetic and epidemiologic studies ..
- Inhibition of IkK to treat lethal Graft-vs.-Host DiseasePatrick Flood; Fiscal Year: 2009..found that poorly soluable drugs that target NF-?B have a modest effect on the occurrence of GVHD in animal models, that is greatly limited by the bioavailability of the compound...
- Alpha B crystallin as a novel therapeutic for SIRS and SepsisJonathan B Rothbard; Fiscal Year: 2011..heat shock protein family, recently has been shown to be a broad based anti-inflammatory agent effective in animal models of multiple sclerosis, rheumatoid arthritis, ischemia-reperfusion injury, and stroke...
- Maternal obesity depresses essential fatty acid transport in the placentaPERRIE F O'TIERNEY-GINN; Fiscal Year: 2012..Her long-term career objective is to build a strong translational research program, utilizing appropriate animal models and human investigations to study the effect of maternal pre-pregnancy nutrition on placental growth and ..
- TLR4 Inhibition to Reduce Cerebral Ischemia Reperfusion InjuryLORI ANN HOLLE; Fiscal Year: 2011..a benefit of TLR4 inhibition in this model, in Phase 2 we propose to determine efficacy of this approach in translational small and large animal models of stroke and acute interventions to restore circulation to ischemic areas of brain.
- Bisphosphonates in the treatment of chronic kidney disease-mineral bone diseaseSharon M Moe; Fiscal Year: 2013..in preventing fractures in multiple non-CKD bone diseases, and can also improve arterial calcification in animal models. Newer bisphosphonates such as zoledronic acid also inhibit angiogenesis through down regulation of vascular ..
- A novel peroxidase in vascular endothelium and the development of atherosclerosisGuangjie Cheng; Fiscal Year: 2012..Nox1 and perhaps other Noxes (but not the phagocyte NADPH-oxidase) are implicated in animal models of Angiotensin II-induced of atherosclerosis and hypertension...
- Cellular Signaling in AlcoholismSubhash C Pandey; Fiscal Year: 2013..It is also known that alcohol can produce anxiolytic effects in both human and animal models and that rapid tolerance to the anxiolytic responses of acute ethanol also develops...
- Monitoring cellular redox signaling and oxidant stress in vivoPaul T Schumacker; Fiscal Year: 2010..The end result should significantly extend our ability to assess ROS in intact tissues, in animal models of disease.
- Adenosine and the Basal Forebrain in the Control of Behavioral StateRobert E Strecker; Fiscal Year: 2012..The biological consequences of CSR have been little investigated due to the relative lack of animal models of CSR...
- Global regulatory interactions in bacterial pathogenesisBRIAN AKERLEY; Fiscal Year: 2009..Consistent with this hypothesis, the redox responsive regulator, ArcA, is required for pathogenesis in animal models. ArcA regulates several virulence phenotypes including LOS outer core modification, serum resistance, and ..
- Tissue-specific delivery of probes by control of membrane trafficking of endoprotBlake Peterson; Fiscal Year: 2010..To facilitate the translation of this approach to higher animal models, we will identify specific proteases that process cholesterylamine-linked peptides in C. elegans...
- Studying the effects of vitamin D on FOXP3 and IL-17 expression in human CD4+ T cInsoo Kang; Fiscal Year: 2010..Overproduction of IL-17 as well as alterations in the numbers and function of FOXP3+ Treg have been linked to animal models of various autoimmune diseases and their human counterparts...
- TARGETING THE MARCKS-FAMILY PROTEINS TO INHIBIT NEUTROPHIL MIGRATIONMary K Sheats; Fiscal Year: 2013..Specific Aim 3 will be accomplished using three different animal models of inflammation: tail-wounding in zebrafish and TNFa induced cremaster injury and LPS-mediated acute lung ..
- Purkinje Origin of Ischemic Ventricular Tachycardia and FibrillationJames B Martins; Fiscal Year: 2013..calcium calmodulin kinase II (CaMKII), a fundamental contributor to VT/VF including reentry in small and large animal models. The overall aim is to test the hypothesis that ROS linked to oxidized CaMKII are basic mechanisms resulting ..
- Regulation of the Vibrio cholerae intestinal exit planANISIA J SILVA BENITEZ; Fiscal Year: 2010..such as bacterial genetics, chromatin immunoprecipitation (ChIP), ChiP-sequencing, confocal microscopy and animal models. In Aim 1, we will determine the regulatory interactions that trigger V. cholerae detachment late in infection...
- DNA Methylation in Ethanol Drinking BehaviorDavid P Gavin; Fiscal Year: 2013..objective is to determine the role of DNA demethylation in alcohol-drinking behavior utilizing two separate animal models. In the first approach, we will utilize one of the most frequently used murine models in alcohol studies, the ..
- Structural Basis for Chemokine FunctionBrian F Volkman; Fiscal Year: 2013..We will also investigate the ability of engineered SDF1 monomers and dimers to alter disease progression in animal models for human diseases including multiple sclerosis, ulcerative colitis, and metastatic cancer...
- Alzheimer's Disease TherapeuticTrevor P Castor; Fiscal Year: 2012..shown that bryostatin 1 not only produces a neuroprotective effect but also enhances cognitive memory in AD animal models. Bryostatin 1 is a complex cyclic macrolide molecule that occurs in very small concentrations (~ 5 to 25 ppm) ..
- Gene Therapy with Cardiotropic Vectors for the Treatment of Heart FailureRoger J Hajjar; Fiscal Year: 2013..Deficient SR Ca2+ uptake during relaxation has been identified in failing hearts from both humans and animal models and has been associated with a decrease in the activity of the SR Ca2+-ATPase (SERCA2a), which is at least ..
- Maternal obesity depresses essential fatty acid transport in the placentaPERRIE F O'TIERNEY-GINN; Fiscal Year: 2013..Her long-term career objective is to build a strong translational research program, utilizing appropriate animal models and human investigations to study the effect of maternal pre-pregnancy nutrition on placental growth and ..
- Therapeutic Effect of a Novel Antioxidant on Degenerative Eye DisordersNuran Ercal; Fiscal Year: 2012..N- acetylcysteine amide (NACA), in preventing and treating cataracts and retinal degeneration in relevant animal models. This application's broad, long-term objectives are to develop an eye drop formulation of NACA for ..
- Targeting CC-Chemokine Receptor 7 for the prevention of graft-versus-host diseaseJAMES M COGHILL; Fiscal Year: 2013..currently no drugs that block the function of CCR7 that are available for use in HSCT patients or for study in animal models. As a result, this proposal describes a strategy for developing antagonists against CCR7...
- PATHOPHYSIOLOGY OF THE ENDOTHELIUMFrancis W Luscinskas; Fiscal Year: 2013..molecular genetic, and experimental pathological approaches in in vitro cell culture and in vivo animal models to gain new insights into the active role of vascular endothelium in inflammation...
- Role of Mitochondria in the Regulation of Iron metabolism by AlcoholDUYGU DEE DEE HARRISON-FINDIK; Fiscal Year: 2012..Of note, ALD patients and animal models of ALD display iron overload but the underlying mechanisms are unclear...
- Arsenic Trioxide and Acute Myeloid LeukemiaYongkui Jing; Fiscal Year: 2012..We propose to study the mechanisms underlying these findings and their effect in primary AML and in vivo (animal models) in 4 specific aims...
- Cellular and Animal Models of FUS Mutations in ALSEric J Huang; Fiscal Year: 2013..DESCRIPTION (provided by applicant): This R21 application is prepared in response to PA-10-138, "Development of Animal Models and Related Biological Materials For Research"...
- Plant-Derived Estrogens and Cell ProliferationEmma Shtivelman; Fiscal Year: 2011..Our objective is to extend these findings to animal models by studying the effect of a range of doses of two plant extracts with ERa activity on the proliferation of ..
- Surgical amelioration of type 2 diabetes: Hormones, microbiota and mitochondriaPETER J contact HAVEL; Fiscal Year: 2010..Thus, the development and utilization of animal models for investigating the mechanisms by which bariatric surgical procedures ameliorate diabetes are urgently ..
- JNK exacerbates ischemia/reperfusion injury in hyperglycemic subjects.Keith A Webster; Fiscal Year: 2010..PUBLIC HEALTH RELEVANCE: Fasting hyperglycemia is associated with increased myocardial infarction in both animal models and patients. Fasting hyperglycemia is also associated with insulin resistance...
- Signaling by Cytoplasmic Tyrosine Kinases in LeukocytesClifford A Lowell; Fiscal Year: 2013..functions of SHP-1 regulated signaling in defined leukocytes which has been impossible to do with previous animal models....
- Overcoming Temozolomide Resistance using MGMT-targeting Spherical Nucleic AcidsTIMOTHY L SITA; Fiscal Year: 2013..degradation, (4) minimal activation of the innate immune response and no acute toxicity at high doses in animal models, and (5) capacity to cross the blood-brain barrier (BBB) and blood-tumor barrier (BTB), penetrate xenografted, ..
- Novel Bioconjugate Vaccines to Prevent Staphylococcus aureus InfectionJEAN CLAIRE LEE; Fiscal Year: 2013..The "bioconjugate" vaccines will be tested in animal models of staphylococcal infection and processed for initial safety testing in humans.
- Intrathoracic Pressure Regulator for ResuscitationKeith G Lurie; Fiscal Year: 2011..Building further upon our recent and significant progress with this device including studies in animal models of cardiac arrest, hemorrhagic shock, and septic shock, the specific aims of this research include: 1) ..
- Targeting AP-1 proteins in COPDSEKHAR M POTHIREDDY; Fiscal Year: 2010..These studies performed in cell culture and animal models provide compelling preliminary evidence that AP-1 signaling plays a role in COPD...
- Genetics of the Neuromuscular Junction: Mechanisms and Disease ModelsRobert W Burgess; Fiscal Year: 2013..This work will lead to improved genetic diagnoses in humans, create directly relevant animal models for preclinical testing of therapies, and identify new therapeutic targets for these diseases, and possibly ..
- The Role of Vascular MR-Regulated Genes in Vascular Function and DiseaseIris Z Jaffe; Fiscal Year: 2013..In animal models of vascular injury and atherosclerosis, aldo infusion increases vascular remodeling and atherosclerosis...
- Regional Biocontainment LaboratoryCharles Bailey; Fiscal Year: 2007..The overall research program will focus on the development of animal models, host-pathogen relationships, aerobiology, and testing of vaccines and therapeutics against aerosol challenge ..
- Prodrugs of NAAG Peptidase Inhibitors for the Treatment of SchizophreniaJia Zhou; Fiscal Year: 2009..supports the involvement of glutamatergic circuits in mediating the symptoms of schizophrenia in humans and animal models of this disorder...
- Prevention of heart failure and death by sphingolipids: outcomes and mechanisms.JOEL KARLINER; Fiscal Year: 2009..to explore new functions of S1P receptor agonism and their mechanisms, and to perform translational studies in animal models. In Specific Aim 1, we will study effects of the selective S1P1 receptor agonist SEW 2871 in two models of ..
- Exon capture and large-scale sequencing for disease-cause identification, early dFriedhelm Hildebrandt; Fiscal Year: 2010..The study of recessive disease mechanisms is particularly powerful, as they can be recapitulated in animal models by gene knockdown/knockout in zebrafish or mice...
- Attenuating the retinal and CNS adverse effects of vigabatrin with NKCC1 inhibitoFrances E Jensen; Fiscal Year: 2010..Vigabatrin also appears to induce injury to white matter tracts (intramyelinic edema) in animal models and MRI white matter abnormalities in human patients...
- FAH-Deficient PigsScott L Nyberg; Fiscal Year: 2011..by applicant): Translational research in the field of liver disease has been limited by a shortage of large animal models, which in turn has limited development of new therapies for metabolic liver disorders, acute liver failure, ..
- Anti-Idiotype Therapy of Human B Cell MalignancyRonald Levy; Fiscal Year: 2007..b>Animal models of B cell lymphoma will be used to develop more powerful methods of vaccination against the idiotype and to ..
- SIRT1 Overexpression in Cellular Mitochondrial Metabolism and FunctionJames Russell; Fiscal Year: 2009..In response to an PA from NCRR (PA-07-336) to develop animal models of human disease that are applicable to the research interests of two or more categorical NIH Institutes/..
- GENE THERAPY FOR HEMOPHILIAMark Kay; Fiscal Year: 2005..with unique services to further advance the study of gene transfer and/or transgene expression in animal models. The common theme of this proposal is AAV-mediated gene based therapies for hemophilia: (#1) Dr...
- ANIMAL MODELS OF MOLECULAR PATHOGENSIS OF HTLV-1Michael Lairmore; Fiscal Year: 2003..Our long term goal is to refine or develop animal models to study genetic determinants of HTLV-1 that allow the establishment of infection in vivo and lead to the ..
- Pathological Evaluation of a Cystic Fibrosis Ferret ModelJohn F Engelhardt; Fiscal Year: 2010..the broad Challenge Area (06) Enabling Technologies, specific Challenge Topic 06-HL- 105: Develop transgenic animal models that are informative for understanding chronic inflammation in humans, and specific Challenge Topic 06-HL-109: ..
- Novel, P. jirovecii Specific Antipneumocystis AgentsAleem Gangjee; Fiscal Year: 2009..is Pneumocystis jirovecii and has remained an elusive target due to a lack of in vitro culture systems and animal models. Pneumocystis carinii, the organism that infects mice and not humans, has been used as a surrogate for the ..
- Towards a Model of Fanconi AnemiaBEVERLY JO TOROK STORB; Fiscal Year: 2010..Challenge area (15): "Translational Science" and the specific Challenge Topic (15-DK-102): "Develop Improved Animal Models of NIDDK Diseases"...
- High resolution functional MRI of columnar structuresRavi Menon; Fiscal Year: 2007..of the fMRI response remain poorly understood in large part because of difficulties in linking studies in animal models under the confounding effects of anesthesia with those done in awake humans...