spectrum analysis

Summary

Summary: The measurement of the amplitude of the components of a complex waveform throughout the frequency range of the waveform. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

Top Publications

  1. ncbi Evidence for wavelike energy transfer through quantum coherence in photosynthetic systems
    Gregory S Engel
    Department of Chemistry and QB3 Institute, University of California, Berkeley, California 94720, USA
    Nature 446:782-6. 2007
  2. ncbi The influence of chromosome density variations on the increase in nuclear disorder strength in carcinogenesis
    Jun Soo Kim
    Department of Biomedical Engineering and Chemistry of Life Processes Institute, Northwestern University, Evanston, IL 60208, USA
    Phys Biol 8:015004. 2011
  3. pmc Discovery of new eunicellins from an Indonesian octocoral Cladiella sp
    Yung Husan Chen
    National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
    Mar Drugs 9:934-43. 2011
  4. pmc Lookup table-based inverse model for determining optical properties of turbid media
    Narasimhan Rajaram
    The University of Texas at Austin, Department of Biomedical Engineering, 1 University Station C0800, Austin, TX 78712, USA
    J Biomed Opt 13:050501. 2008
  5. pmc A fiber optic probe design to measure depth-limited optical properties in-vivo with low-coherence enhanced backscattering (LEBS) spectroscopy
    Nikhil N Mutyal
    Department of Biomedical Engineering, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA
    Opt Express 20:19643-57. 2012
  6. pmc Performance metrics of an optical spectral imaging system for intra-operative assessment of breast tumor margins
    Torre M Bydlon
    Department of Biomedical Engineering, Duke University, 136 Hudson Hall, Box 90281, Durham, NC, 27708, USA
    Opt Express 18:8058-76. 2010
  7. pmc Rapid noninvasive optical imaging of tissue composition in breast tumor margins
    Lee G Wilke
    Department of Surgery, Duke University Health System, 3116 North Duke St, Durham, NC 27704, USA
    Am J Surg 198:566-74. 2009
  8. pmc HDAC up-regulation in early colon field carcinogenesis is involved in cell tumorigenicity through regulation of chromatin structure
    Yolanda Stypula-Cyrus
    Biomedical Engineering Department, Northwestern University, Evanston, Illinois, United States of America
    PLoS ONE 8:e64600. 2013
  9. pmc Ion mobility spectrometry for microbial volatile organic compounds: a new identification tool for human pathogenic bacteria
    Melanie Jünger
    Department of Anesthesiology, Emergency and Intensive Care Medicine, University of Gottingen, Gottingen, Germany
    Appl Microbiol Biotechnol 93:2603-14. 2012
  10. ncbi Quantitative investigations of quantum coherence for a light-harvesting protein at conditions simulating photosynthesis
    Daniel B Turner
    Department of Chemistry, Institute for Optical Sciences, and Centre for Quantum Information and Quantum Control, 80 St George Street, Toronto, Ontario, M5S 3H6, Canada
    Phys Chem Chem Phys 14:4857-74. 2012

Detail Information

Publications369 found, 100 shown here

  1. ncbi Evidence for wavelike energy transfer through quantum coherence in photosynthetic systems
    Gregory S Engel
    Department of Chemistry and QB3 Institute, University of California, Berkeley, California 94720, USA
    Nature 446:782-6. 2007
    ..This wavelike characteristic of the energy transfer within the photosynthetic complex can explain its extreme efficiency, in that it allows the complexes to sample vast areas of phase space to find the most efficient path...
  2. ncbi The influence of chromosome density variations on the increase in nuclear disorder strength in carcinogenesis
    Jun Soo Kim
    Department of Biomedical Engineering and Chemistry of Life Processes Institute, Northwestern University, Evanston, IL 60208, USA
    Phys Biol 8:015004. 2011
    ..Coupled with PWS measurements, the simulation results suggest that the chromosome condensation and the resulting spatial density inhomogeneity may represent one of the earliest events in carcinogenesis...
  3. pmc Discovery of new eunicellins from an Indonesian octocoral Cladiella sp
    Yung Husan Chen
    National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
    Mar Drugs 9:934-43. 2011
    ..The previously reported structures of two eunicellin-based compounds, cladielloides A and B, are corrected in this study...
  4. pmc Lookup table-based inverse model for determining optical properties of turbid media
    Narasimhan Rajaram
    The University of Texas at Austin, Department of Biomedical Engineering, 1 University Station C0800, Austin, TX 78712, USA
    J Biomed Opt 13:050501. 2008
    ..35). We also present in vivo data from clinically normal and malignant nonmelanoma skin cancers fit to the LUT-based model...
  5. pmc A fiber optic probe design to measure depth-limited optical properties in-vivo with low-coherence enhanced backscattering (LEBS) spectroscopy
    Nikhil N Mutyal
    Department of Biomedical Engineering, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA
    Opt Express 20:19643-57. 2012
    ..Additionally, depth-limited capabilities are demonstrated using Monte Carlo modeling and experimental measurements from a two-layered phantom...
  6. pmc Performance metrics of an optical spectral imaging system for intra-operative assessment of breast tumor margins
    Torre M Bydlon
    Department of Biomedical Engineering, Duke University, 136 Hudson Hall, Box 90281, Durham, NC, 27708, USA
    Opt Express 18:8058-76. 2010
    ..The manuscript includes a discussion of how the speed of the system can be improved to work within the time constraints of an intra-operative setting...
  7. pmc Rapid noninvasive optical imaging of tissue composition in breast tumor margins
    Lee G Wilke
    Department of Surgery, Duke University Health System, 3116 North Duke St, Durham, NC 27704, USA
    Am J Surg 198:566-74. 2009
    ..Our objective is to develop an optically based technology which can differentiate benign from malignant breast tissues intraoperatively through differences in tissue composition factors...
  8. pmc HDAC up-regulation in early colon field carcinogenesis is involved in cell tumorigenicity through regulation of chromatin structure
    Yolanda Stypula-Cyrus
    Biomedical Engineering Department, Northwestern University, Evanston, Illinois, United States of America
    PLoS ONE 8:e64600. 2013
    ..Together, these results demonstrate the importance of HDAC activity in early carcinogenic events and the unique role of higher-order chromatin structure in determining cell tumorigenicity...
  9. pmc Ion mobility spectrometry for microbial volatile organic compounds: a new identification tool for human pathogenic bacteria
    Melanie Jünger
    Department of Anesthesiology, Emergency and Intensive Care Medicine, University of Gottingen, Gottingen, Germany
    Appl Microbiol Biotechnol 93:2603-14. 2012
    ..In a hospital routine, this method could enable the identification of pathogens already after 24 h with the consequence that a specific therapy could be initiated significantly earlier...
  10. ncbi Quantitative investigations of quantum coherence for a light-harvesting protein at conditions simulating photosynthesis
    Daniel B Turner
    Department of Chemistry, Institute for Optical Sciences, and Centre for Quantum Information and Quantum Control, 80 St George Street, Toronto, Ontario, M5S 3H6, Canada
    Phys Chem Chem Phys 14:4857-74. 2012
    ..Here we measured 2D ES of PC645 at increasing levels of acidity to determine if the change in pH affects the quantum coherence; quantitative analysis reveals that the dynamics are insensitive to the pH change...
  11. pmc Multiple scattering model for the penetration depth of low-coherence enhanced backscattering
    Vladimir Turzhitsky
    Northwestern University, Department of Biomedical Engineering, Evanston, Illinois 60208, USA
    J Biomed Opt 16:097006. 2011
    ..The expression is shown to be accurate for a broad range of experimentally relevant optical properties and spatial coherence lengths...
  12. pmc Studies on the site and mode of TMPyP4 interactions with Bcl-2 promoter sequence G-Quadruplexes
    Narayana Nagesh
    Centre for Cellular and Molecular Biology, Hyderabad, India
    Biophys J 98:2628-33. 2010
    ..The change in fluorescence for 2-AP bases in the second half of the TMPyP4 titration lends support to our previous speculation regarding the intercalative nature of the weaker binding mode...
  13. ncbi The effect of brain hematoma location on volumetric inductive phase shift spectroscopy of the brain with circular and magnetron sensor coils: a numerical simulation study
    R Rojas
    Universidad del Ejército y FAM EMGS Laboratorio Multidisciplinario de Investigación, DF, Mexico
    Physiol Meas 29:S255-66. 2008
    ..Furthermore it was found that the relative sensitivity of circular and magnetron sensor coils with respect to the occurrence of hematoma varies with the location of the hematoma...
  14. ncbi Norpregnane glycosides from a Thai soft coral, Scleronephthya pallida
    P Kittakoop
    National Center for Genetic Engineering and Biotechnology, NSTDA, 73 1 Rama VI Road, Rajdhevee, Bangkok 10400, Thailand
    J Nat Prod 62:318-20. 1999
    ..19-Norpregna-1,3,5(10), 20-tetraen-3-O-alpha-fucopyranoside (3) exhibits moderate antimalarial and cytotoxic activities. The chemical structures of 1-4 were elucidated from spectroscopic data...
  15. pmc Five sesquiterpenoids from a marine-derived fungus Aspergillus sp. isolated from a gorgonian Dichotella gemmacea
    Mei Yan Wei
    School of Pharmacy, Guangdong Medical College, Dongguan, 523808, China
    Mar Drugs 8:941-9. 2010
    ..Their structures were elucidated by combined spectroscopic methods, and the structure of 1 was further confirmed by single-crystal X-ray data...
  16. pmc Neuronal ensemble bursting in the basal forebrain encodes salience irrespective of valence
    Shih Chieh Lin
    Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Neuron 59:138-49. 2008
    ....
  17. ncbi Ultrasonic spectral parameter characterization of apoptosis
    M C Kolios
    Department of Mathematics, Physics and Computer Science, Ryerson University, Toronto, Ontario, Canada
    Ultrasound Med Biol 28:589-97. 2002
    ..The results provide a framework for using spectral parameter methods to monitor apoptosis in in vitro and in in vivo systems and are being used to guide the design of system and signal analysis parameters...
  18. ncbi Carotenoid cation formation and the regulation of photosynthetic light harvesting
    Nancy E Holt
    Department of Chemistry, University of California, Berkeley, CA 94720, USA
    Science 307:433-6. 2005
    ..These results indicate that energy transfer from chlorophyll molecules to a chlorophyllzeaxanthin heterodimer, which then undergoes charge separation, is the mechanism for excess energy dissipation during feedback deexcitation...
  19. pmc The density and refractive index of adsorbing protein layers
    Janos Voros
    BioInterface Group, Laboratory for Surface Science and Technology, ETH Zurich, Schlieren, Switzerland
    Biophys J 87:553-61. 2004
    ..Our measurements indicated that water and solvent molecules not only influence the 3D structure of proteins in solution but also play a crucial role in their adsorption onto surfaces...
  20. pmc Nanoscale cellular changes in field carcinogenesis detected by partial wave spectroscopy
    Hariharan Subramanian
    Biomedical Engineering Department, Northwestern University, Evanston, Illinois, USA
    Cancer Res 69:5357-63. 2009
    ..These results have important implications in that PWS can be used as a new method to identify patients harboring malignant or premalignant tumors by interrogating easily accessible tissue sites distant from the location of the lesion...
  21. pmc Quantitative optical spectroscopy: a robust tool for direct measurement of breast cancer vascular oxygenation and total hemoglobin content in vivo
    J Quincy Brown
    Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA
    Cancer Res 69:2919-26. 2009
    ..Diffuse reflectance spectroscopy could aid in prognosis and prediction in breast cancer via quantitative assessment of tumor physiology at the time of diagnostic biopsy...
  22. pmc Increased sensitivity and extended range of distance measurements in spin-labeled membrane proteins: Q-band double electron-electron resonance and nanoscale bilayers
    Ping Zou
    Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee
    Biophys J 98:L18-20. 2010
    ..The advances described here set the stage for the use of DEER spectroscopy to analyze conformational dynamics of sample-limited eukaryotic membrane proteins...
  23. ncbi Comparison of different aminofunctionalization strategies for attachment of single antibodies to AFM cantilevers
    Andreas Ebner
    Institute of Biophysics, University of Linz, 4040 Linz, Austria
    Ultramicroscopy 107:922-7. 2007
    ....
  24. pmc An optical marker based on the UV-induced green-to-red photoconversion of a fluorescent protein
    Ryoko Ando
    Laboratory for Cell Function and Dynamics, Advanced Technology Development Center, Brain Science Institute, The Institute of Physical and Chemical Research RIKEN, 2 1 Hirosawa, Wako City, Saitama 351 0198, Japan
    Proc Natl Acad Sci U S A 99:12651-6. 2002
    ..Illumination of a focused UV pulse onto the soma of a Kaede-expressing neuron resulted in filling of all processes with red fluorescence, allowing visualization of contact sites between the red and green neurons of interest...
  25. ncbi Analyses of mouse breath with ion mobility spectrometry: a feasibility study
    Wolfgang Vautz
    ISAS Institute for Analytical Sciences, Department of Metabolomics, Bunsen Kirchhoff Strasse 11, 44139 Dortmund, Germany
    J Appl Physiol (1985) 108:697-704. 2010
    ..Nevertheless, the results of the study demonstrate that the method is capable of rapid analyses of the breath of mice, thus significantly increasing the information obtained from each particular animal experiment...
  26. ncbi Bronchoscopically obtained volatile biomarkers in lung cancer
    Kaid Darwiche
    Department of Interventional Pneumology, Ruhrlandklinik, University Hospital Essen, University of Essen, Tuschener Weg 40, 45239, Essen, Germany
    Lung 189:445-52. 2011
    ..These VOCs can be detected with methods such as ion mobility spectrometry (IMS); their origin remains unknown...
  27. pmc Golden carbon nanotubes as multimodal photoacoustic and photothermal high-contrast molecular agents
    Jin Woo Kim
    Department of Biological and Agricultural Engineering and Institute for Nanoscale Materials Science and Engineering, University of Arkansas, Fayetteville, Arkansas 72701, USA
    Nat Nanotechnol 4:688-94. 2009
    ..This new nanomaterial could be an effective alternative to existing nanoparticles and fluorescent labels for non-invasive targeted imaging of molecular structures in vivo...
  28. pmc Noninvasive evaluation of oral lesions using depth-sensitive optical spectroscopy
    Richard A Schwarz
    Department of Bioengineering, Rice University, Houston, Texas, USA
    Cancer 115:1669-79. 2009
    ..In this study, we evaluated the diagnostic performance of a depth-sensitive optical spectroscopy (DSOS) system for distinguishing dysplasia and carcinoma from non-neoplastic oral mucosa...
  29. ncbi A two-dimensional spectrum analysis for sedimentation velocity experiments of mixtures with heterogeneity in molecular weight and shape
    Emre Brookes
    Department of Biochemistry, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, MC 7760, San Antonio, TX 78229 3901, USA
    Eur Biophys J 39:405-14. 2010
    ....
  30. pmc Measurement of optical scattering properties with low-coherence enhanced backscattering spectroscopy
    Vladimir Turzhitsky
    Northwestern University, Department of Biomedical Engineering, Evanston, Illinois 60208, USA
    J Biomed Opt 16:067007. 2011
    ..Three inverse models for calculating these optical properties are described and the calculations are validated with an experimental measurement from a tissue phantom...
  31. ncbi Structure-based simulation of linear optical spectra of the CP43 core antenna of photosystem II
    Frank Müh
    Institut fur Theoretische Physik, Johannes Kepler Universitat Linz, Altenberger Str 69, 4040, Linz, Austria
    Photosynth Res 111:87-101. 2012
    ....
  32. ncbi An international activity and spectrum analysis of linezolid: ZAAPS Program results for 2011
    Robert K Flamm
    JMI Laboratories, North Liberty, IA 52317, USA
    Diagn Microbiol Infect Dis 76:206-13. 2013
    ..As the activities of commonly used antimicrobials continue to be compromised by evolving resistance mechanisms in Gram-positive pathogens, linezolid-resistant strains remain uncommon and without increasing occurrence...
  33. ncbi Diffuse optical imaging and spectroscopy of the breast: a brief outline of history and perspectives
    Paola Taroni
    Dipartimento di Fisica, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133, Milan, Italy
    Photochem Photobiol Sci 11:241-50. 2012
    ..This paper outlines the historical evolution of optical imaging and spectroscopy of the breast, highlighting potentialities and limitations, and presents an overview of the main applications and perspectives of the field...
  34. pmc Early and late stimulus-evoked cortical hemodynamic responses provide insight into the neurogenic nature of neurovascular coupling
    Aneurin J Kennerley
    Department of Psychology, University of Sheffield, Sheffield, UK
    J Cereb Blood Flow Metab 32:468-80. 2012
    ..Although data did not clearly dissociate early and late vascular responses, they suggest that the neurovascular coupling relationship is neurogenic in origin...
  35. ncbi Structure-based calculations of optical spectra of photosystem I suggest an asymmetric light-harvesting process
    Julian Adolphs
    Institut fur Chemie und Biochemie, Freie Universitat Berlin, Fabeckstrasse 36a, D 14195 Berlin, Germany
    J Am Chem Soc 132:3331-43. 2010
    ..This asymmetry in light-harvesting may provide the key for understanding the asymmetric use of the two branches in primary electron transfer reactions. Experiments are suggested to check for this possibility...
  36. pmc Alignment of retention time obtained from multicapillary column gas chromatography used for VOC analysis with ion mobility spectrometry
    Thorsten Perl
    Department of Anaesthesiology, Emergency and Intensive Care Medicine, University of Gottingen, 37073 Gottingen, Germany
    Anal Bioanal Chem 397:2385-94. 2010
    ....
  37. pmc Aminolevulinic acid-photodynamic therapy combined with topically applied vascular disrupting agent vadimezan leads to enhanced antitumor responses
    ALLISON MARRERO
    Department of Molecular Pharmacology and Cancer Therapeutics, Roswell Park Cancer Institute, Buffalo, NY, USA
    Photochem Photobiol 87:910-9. 2011
    ..In conclusion, vadimezan as a topical agent enhances treatment efficacy when combined with ALA-PDT. This combination could be useful in clinical applications...
  38. pmc Quantitative optical spectroscopy can identify long-term local tumor control in irradiated murine head and neck xenografts
    Karthik Vishwanath
    Duke University, Department of Biomedical Engineering, 136 Hudson Hall, Box 90281, Durham, North Carolina 27708, USA
    J Biomed Opt 14:054051. 2009
    ....
  39. ncbi Intra-operative brain tumor detection using elastic light single-scattering spectroscopy: a feasibility study
    Murat Canpolat
    Akdeniz University, School of Medicine, Department of Biophysics, Antalya, 07059, Turkey
    J Biomed Opt 14:054021. 2009
    ..Our results indicate that signs of spectral slopes may enable the discrimination of brain tumors from surrounding normal white matter brain tissue with a sensitivity of 93% and specificity of 100%...
  40. ncbi Blind source unmixing in multi-spectral optoacoustic tomography
    Jürgen Glatz
    Institute for Biological and Medical Imaging, Technische Universität München and Helmholtz Zentrum München, Munich, Germany
    Opt Express 19:3175-84. 2011
    ..We further demonstrate its capacity with temporal unmixing on real-time MSOT data obtained in-vivo for enhancing the visualization of absorber agent flow in the mouse vascular system...
  41. ncbi Probing the relation between force--lifetime--and chemistry in single molecular bonds
    E Evans
    Physics and Pathology, University of British Columbia, Vancouver, V6T 2A6, Canada
    Annu Rev Biophys Biomol Struct 30:105-28. 2001
    ....
  42. pmc Refinement of optical imaging spectroscopy algorithms using concurrent BOLD and CBV fMRI
    Aneurin J Kennerley
    Centre for Signal Processing in Neuroimaging and Systems Neuroscience SPiNSN, Department of Psychology, University of Sheffield, Western Bank, Sheffield, UK
    Neuroimage 47:1608-19. 2009
    ....
  43. ncbi The detection of brain oedema with frequency-dependent phase shift electromagnetic induction
    César A González
    University of California, Berkeley, USA
    Physiol Meas 27:539-52. 2006
    ..The phase shift increases with frequency and fluid content. The results suggest that measuring phase shift in the bulk of the brain has the potential for becoming a robust means for non-contact detection of oedema in the brain...
  44. ncbi Resonant Mie scattering in infrared spectroscopy of biological materials--understanding the 'dispersion artefact'
    Paul Bassan
    School of Chemical Engineering and Analytical Science, Manchester Interdisciplinary Biocentre, The University of Manchester, 131 Princess Street, Manchester, UK M1 7DN
    Analyst 134:1586-93. 2009
    ....
  45. pmc Investigating population risk factors of pancreatic cancer by evaluation of optical markers in the duodenal mucosa
    Vladimir Turzhitsky
    Biomedical Engineering Department, Northwestern University, Evanston, IL, USA
    Dis Markers 25:313-21. 2008
    ....
  46. ncbi High-time-resolution pump-probe system with broadband detection for the study of time-domain vibrational dynamics
    Dario Polli
    National Laboratory for Ultrafast and Ultraintense Optical Science CNR INFM, Dipartimento di Fisica, Politecnico di Milano, P za L da Vinci 32, 20133 Milano, Italy
    Rev Sci Instrum 78:103108. 2007
    ....
  47. ncbi New mono- and dimeric members of the secalonic acid family: blennolides A-G isolated from the fungus Blennoria sp
    Wen Zhang
    Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo He Road, Shanghai 200433, PR China
    Chemistry 14:4913-23. 2008
    ..They were also active against the alga Chlorella fusca and the bacterium Escherichia coli...
  48. pmc Spectroscopic microvascular blood detection from the endoscopically normal colonic mucosa: biomarker for neoplasia risk
    Hemant K Roy
    Department of Internal Medicine, Evanston Northwestern Healthcare, Evanston, Illinois 60201, USA
    Gastroenterology 135:1069-78. 2008
    ..To assess the potential clinical translatability of this putative field effect marker, we characterized the early increase in blood supply (EIBS) in human beings in vivo...
  49. ncbi Continuous, noninvasive, and localized microvascular tissue oximetry using visible light spectroscopy
    David A Benaron
    Biomedical Optics Laboratory, and Department of Pediatrics, Stanford Hospital and Livermore Veterans Affairs Medical Center, Palo Alto, California 94305, USA
    Anesthesiology 100:1469-75. 2004
    ..Unlike near-infrared spectroscopy or pulse oximetry (SpO2), VLS tissue oximetry uses shallow-penetrating visible light to measure microvascular hemoglobin oxygen saturation (StO2) in small, thin tissue volumes...
  50. ncbi Biological tissue characterization by magnetic induction spectroscopy (MIS): requirements and limitations
    Hermann Scharfetter
    Institute for Biomedical Engineering, Graz University of Technology, Inffeldgasse 18, A 8010 Graz, Austria
    IEEE Trans Biomed Eng 50:870-80. 2003
    ..Changes of the magnetic permeability and permittivity in biological tissues are more complicated to deal with and may require chopping techniques, e.g., periodic movement of the object...
  51. ncbi Imaging human epithelial properties with polarized light-scattering spectroscopy
    R S Gurjar
    G.R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Nat Med 7:1245-8. 2001
    ....
  52. ncbi Probing the FQR and NDH activities involved in cyclic electron transport around Photosystem I by the 'afterglow' luminescence
    Michel Havaux
    CEA Cadarache, DSV, DEVM, laboratoire d écophysiologie de la photosynthèse, UMR 6191 CNRS CEA Aix Marseille II, F 13108 Saint Paul lez Durance, France
    Biochim Biophys Acta 1709:203-13. 2005
    ..The afterglow thermoluminescence band provides a new and simple tool to investigate the cyclic electron transfer pathways and to study their regulation in vivo...
  53. ncbi Assessing carotenoid content in plant leaves with reflectance spectroscopy
    Anatoly A Gitelson
    School of Natural Resource Sciences, University of Nebraska Lincoln, 68588 0517, USA
    Photochem Photobiol 75:272-81. 2002
    ..5 nm and the near infrared range above 750 nm are sufficient to estimate total Car content in plant leaves nondestructively with a root mean square error of less than 1.75 nmol/cm2...
  54. pmc Quantitative imaging of scattering changes associated with epithelial proliferation, necrosis, and fibrosis in tumors using microsampling reflectance spectroscopy
    Venkataramanan Krishnaswamy
    Dartmouth College, Thayer School of Engineering, 8000 Cummings Hall, Hanover, New Hampshire 03755, USA
    J Biomed Opt 14:014004. 2009
    ....
  55. ncbi Location of brain rhythms and their modulation by preparatory attention estimated by current density
    C M Gomez
    Psychobiology Laboratory, Department of Experimental Psychology, University of Sevilla, Spain
    Brain Res 1107:151-60. 2006
    ....
  56. ncbi Solvent tuning of electrochemical potentials in the active sites of HiPIP versus ferredoxin
    Abhishek Dey
    Department of Chemistry, Stanford University, Stanford, CA 94305, USA
    Science 318:1464-8. 2007
    ....
  57. ncbi New technology for diagnosis of bacterial vaginosis
    Walter Chaim
    Department of Obstetrics and Gynecology, Faculty of Health Sciences, Soroka University Medical Center, Ben Gurion University of the Negev, P O Box 151, Beer Sheva 84101, Israel
    Eur J Obstet Gynecol Reprod Biol 111:83-7. 2003
    ..The technique is particularly sensitive to amines taking less than 2 min...
  58. ncbi Long-term effects of stroke on neuronal rest activity in rolandic cortical areas
    F Tecchio
    ISTC CNR, Dip Neuroscienze, Osp Fatebenefratelli, Roma, Italy
    J Neurosci Res 83:1077-87. 2006
    ..Total power increase and spectral richness decrease are in agreement with a higher synchrony of local neuronal activity, a reduction of the intracortical inhibitory network's efficiency, and an increase of neuronal excitability...
  59. ncbi Discrete interactions in cell adhesion measured by single-molecule force spectroscopy
    M Benoit
    Centre for Nanoscience, Ludwig Maximilians Universitat Munchen, Amalienstrabetae 54, D 80799 Munchen, Germany
    Nat Cell Biol 2:313-7. 2000
    ..Adhesion between two adjacent cell surfaces involves discrete interactions characterized by an unbinding force of 23 +/- 8 pN, measured at a rupture rate of 2.5 +/- 0.5 microm s-1...
  60. pmc Quantitative spectroscopic imaging for non-invasive early cancer detection
    Chung Chieh Yu
    George R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Opt Express 16:16227-39. 2008
    ..We demonstrate its accuracy using physical tissue models. We validate its diagnostic ability on a resected colon adenoma, and demonstrate feasibility of in vivo imaging in the oral cavity...
  61. ncbi Melanin optical properties provide evidence for chemical and structural disorder in vivo
    George Zonios
    Department of Materials Science and Engineering, University of Ioannina, 45110 Ioannina, Greece
    Opt Express 16:8263-8. 2008
    ....
  62. ncbi Melanin absorption spectroscopy: new method for noninvasive skin investigation and melanoma detection
    George Zonios
    University of Ioannina, Department of Materials Science and Engineering, 45110 Ioannina, Greece
    J Biomed Opt 13:014017. 2008
    ..It is also a promising approach for a better understanding of the biological role, structure, and function of melanin...
  63. pmc Dynamic force spectroscopy of parallel individual Mucin1-antibody bonds
    Todd A Sulchek
    Lawrence Livermore National Laboratory, Livermore, CA 94550, USA
    Proc Natl Acad Sci U S A 102:16638-43. 2005
    ..Our approach is promising for comparison of the specific effects of molecular modifications as well as for determination of the best configuration of antibody-based multivalent targeting agents...
  64. ncbi Polarization-consistent versus correlation-consistent basis sets in predicting molecular and spectroscopic properties
    Teobald Kupka
    Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan
    J Phys Chem A 111:1927-32. 2007
    ..g., NMR parameters) for larger systems such as the active site of enzymes...
  65. ncbi Evolution of color variation in dragon lizards: quantitative tests of the role of crypsis and local adaptation
    Devi M Stuart-Fox
    Department of Zoology and Entomology, University of Queensland, St Lucia, Q 4072, Australia
    Evolution 58:1549-59. 2004
    ....
  66. ncbi Plasticity in the rat posterior auditory field following nucleus basalis stimulation
    Amanda C Puckett
    Neuroscience Program, School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75083 0688, USA
    J Neurophysiol 98:253-65. 2007
    ..These results demonstrate that experience-dependent plasticity can take different forms in both A1 and secondary auditory cortex...
  67. ncbi Heme to protein linkages in mammalian peroxidases: impact on spectroscopic, redox and catalytic properties
    Martina Zederbauer
    BOKU University of Natural Resources and Applied Life Sciences, Department of Chemistry, Division of Biochemistry, Muthgasse 18, A 1190 Vienna, Austria
    Nat Prod Rep 24:571-84. 2007
  68. ncbi Evolution of the cichlid visual palette through ontogenetic subfunctionalization of the opsin gene arrays
    Tyrone C Spady
    Hubbard Center for Genome Studies and Department of Zoology, University of New Hampshire, London, UK
    Mol Biol Evol 23:1538-47. 2006
    ..The distinct peak absorbances of these preserved opsin genes provide a palette from which selection creates the diverse visual sensitivities found among the cichlid species of the lacustrine adaptive radiations...
  69. pmc Machine learning based prediction for peptide drift times in ion mobility spectrometry
    Anuj R Shah
    Fundamental and Computational Sciences Directorate, Pacific Northwest National Laboratory, 999 Battelle Boulevard, Richland, WA 99352, USA
    Bioinformatics 26:1601-7. 2010
    ..This model is used in conjunction with two mathematical techniques, a partial least squares regression and a support vector regression setting...
  70. pmc Optical breast cancer margin assessment: an observational study of the effects of tissue heterogeneity on optical contrast
    Stephanie Kennedy
    Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA
    Breast Cancer Res 12:R91. 2010
    ..Here, we evaluate ex-vivo breast tissue and determine which sources of optical contrast have the potential to detect malignancy at the margins in women of differing breast composition...
  71. ncbi Electromagnetic cellular interactions
    Michal Cifra
    Institute of Photonics and Electronics, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Prog Biophys Mol Biol 105:223-46. 2011
    ..Although small, it is continuously accumulating...
  72. ncbi Sputum trace metals are biomarkers of inflammatory and suppurative lung disease
    Robert D Gray
    School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland
    Chest 137:635-41. 2010
    ..Increases in sputum iron have been described in inflammatory lung disease. We hypothesized that other sputum metals may be affected by airways inflammation and investigated their potential value as biomarkers...
  73. ncbi Reflectance spectroscopy for in vivo detection of cervical precancer
    Yvette N Mirabal
    University of Texas M D Anderson Cancer Center, Biomedical Engineering Center, Houston, Texas 77030, USA
    J Biomed Opt 7:587-94. 2002
    ..Thus, reflectance spectroscopy appears promising for in vivo detection of cervical precancer. Strategies that combine fluorescence and reflectance spectroscopy may enhance the discrimination capabilities...
  74. ncbi Relationships between leaf chlorophyll content and spectral reflectance and algorithms for non-destructive chlorophyll assessment in higher plant leaves
    Anatoly A Gitelson
    Center for Advanced Land Management Information Technologies, School of Natural Resource Sciences, University of Nebraska Lincoln, 113 Nebraska Hall, Lincoln, NE 68588 0517, USA
    J Plant Physiol 160:271-82. 2003
    ..Two independent data sets were used to validate the developed algorithms. The root mean square error of the chlorophyll prediction did not exceed 50 mumol/m2 in leaves with total chlorophyll ranged from 1 to 830 mumol/m2...
  75. ncbi Fiber optic probes for biomedical optical spectroscopy
    Urs Utzinger
    University of Arizona, Biomedical Engineering and Obstetrics and Gynecology, Tucson, Arizona 85724, USA
    J Biomed Opt 8:121-47. 2003
    ..The design of probes for reflectance, polarized reflectance, fluorescence, and Raman spectroscopy is illustrated. We cover universal design principles as well as technologies for beam deflecting and reshaping...
  76. ncbi Polarized angular dependent spectroscopy of epithelial cells and epithelial cell nuclei to determine the size scale of scattering structures
    J R Mourant
    Los Alamos National Laboratory, Bioscience Division, Los Alamos, New Mexico 87545, USA
    J Biomed Opt 7:378-87. 2002
    ..Light scattering is likely sensitive to structures smaller than those commonly investigated by standard pathology methods...
  77. ncbi Understanding the elasticity of fibronectin fibrils: unfolding strengths of FN-III and GFP domains measured by single molecule force spectroscopy
    Nehal I Abu-Lail
    Center for Biologically Inspired Materials and Material Systems, Duke University, Durham, NC 27708, USA
    Matrix Biol 25:175-84. 2006
    ..Our results thus favor an alternative model, which invokes a conformational change from a compact to an extended conformation, as the basis for FN fibril elasticity...
  78. ncbi Calculation of pigment transition energies in the FMO protein: from simplicity to complexity and back
    Julia Adolphs
    Institut fur Chemie und Biochemie, Freie Universitat Berlin, Takustrasse 6, Berlin, 14195, Germany
    Photosynth Res 95:197-209. 2008
    ....
  79. ncbi Monitoring neoadjuvant chemotherapy in breast cancer using quantitative diffuse optical spectroscopy: a case study
    Dorota B Jakubowski
    Beckman Laser Institute, Laser Microbeam and Medical Program, University of California Irvine, 1002 Health Sciences Road East, Irvine, CA 92612, USA
    J Biomed Opt 9:230-8. 2004
    ..These data suggest that noninvasive, quantitative optical methods that characterize tumor physiology may be useful in assessing and optimizing individual response to neoadjuvant chemotherapy...
  80. ncbi Portable optical tissue flow oximeter based on diffuse correlation spectroscopy
    Yu Shang
    Center for Biomedical Engineering, University of Kentucky, Lexington, Kentucky 40506, USA
    Opt Lett 34:3556-8. 2009
    ..9, P<10(-5), n=10). The portable, inexpensive, and easy-to-use DCS flow oximeter holds promise for bedside monitoring of tissue blood flow and oxygenation in clinics...
  81. ncbi Pathogenic mutations shift the equilibria of alpha-synuclein single molecules towards structured conformers
    Marco Brucale
    Department of Biochemistry, University of Bologna, Via Irnerio 48, Bologna, Italy
    Chembiochem 10:176-83. 2009
    ..The more structured and globular conformations of the mutants can explain their higher propensity to aggregate with respect to the WT...
  82. ncbi Cerebral monitoring during carotid endarterectomy using near-infrared diffuse optical spectroscopies and electroencephalogram
    Yu Shang
    Center for Biomedical Engineering, University of Kentucky, KY, USA
    Phys Med Biol 56:3015-32. 2011
    ..g., shunting, medications) during CEA to reduce the risks of severe cerebral ischemia and cerebral hyperperfusion syndrome...
  83. ncbi Blue- and green-absorbing visual pigments of Drosophila: ectopic expression and physiological characterization of the R8 photoreceptor cell-specific Rh5 and Rh6 rhodopsins
    E Salcedo
    Institute of Biotechnology, Department of Molecular Medicine, University of Texas Health Science Center, San Antonio, Texas 78245, USA
    J Neurosci 19:10716-26. 1999
    ....
  84. ncbi Detection of characteristic metabolites of Aspergillus fumigatus and Candida species using ion mobility spectrometry-metabolic profiling by volatile organic compounds
    Thorsten Perl
    Department of Anaesthesiology, Emergency and Intensive Care Medicine, University of Gottingen, Gottingen, Germany
    Mycoses 54:e828-37. 2011
    ..Discrimination of fungi on genus level of the investigated germs by volatile metabolic profile and therefore detection of VOC is feasible. However, a further discrimination on species level for Candida species was not possible...
  85. ncbi Assessment of oral premalignancy using elastic scattering spectroscopy
    A Sharwani
    Oral and Maxillofacial Surgery, Eastman Dental Institute, UCL, London, UK
    Oral Oncol 42:343-9. 2006
    ..Large, multi-centre trails are needed for each anatomical site, in order to gather more information about the differences between normal and dysplastic tissue...
  86. pmc Photon diffusion near the point-of-entry in anisotropically scattering turbid media
    Edward Vitkin
    Center for Advanced Biomedical Imaging and Photonics, Department of Obstetrics, Gynecology and Reproductive Biology, Harvard University and Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Nat Commun 2:587. 2011
    ..We demonstrate that the theory is in excellent agreement with both experimental results and Monte Carlo simulations for several commonly used phase functions...
  87. pmc Flexibilins A-C, new cembrane-type diterpenoids from the Formosan soft coral, Sinularia flexibilis
    Li Chung Hu
    Graduate Institute of Marine Biotechnology and Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
    Mar Drugs 11:1999-2012. 2013
    ..The structure of 4, including its absolute stereochemistry, was further confirmed by single-crystal X-ray diffraction analysis. Cembrane 2 displayed a moderate inhibitory effect on the release of elastase by human neutrophils...
  88. ncbi Two-dimensional electronic spectroscopy of bacteriochlorophyll a in solution: Elucidating the coherence dynamics of the Fenna-Matthews-Olson complex using its chromophore as a control
    Kelly A Fransted
    Department of Chemistry and The James Franck Institute, The University of Chicago, Chicago, Illinois 60637, USA
    J Chem Phys 137:125101. 2012
    ..Our results suggest that the beating observed in spectra of FMO is of a radically different character than the signals observed here and can therefore be attributed to electronic coherences or intermolecular degrees of freedom...
  89. ncbi Excitation energy pathways in the photosynthetic units of reaction center LM- and H-subunit deletion mutants of Rhodospirillum rubrum
    Sergiu Amarie
    Institute for Physical and Theoretical Chemistry, Institute of Biophysics, Johann Wolfgang Goethe University Frankfurt, Max von Laue Str 7, Building N120 224, 60438, Frankfurt am Main, Germany
    Photosynth Res 103:141-51. 2010
    ....
  90. ncbi Non-invasive measurement of the microvascular properties of non-dysplastic and dysplastic oral leukoplakias by use of optical spectroscopy
    A Amelink
    Center for Optical Diagnostics and Therapy, Department of Radiation Oncology, Erasmus Medical Centre, Rotterdam, The Netherlands
    Oral Oncol 47:1165-70. 2011
    ....
  91. ncbi Forces and bond dynamics in cell adhesion
    Evan A Evans
    Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA
    Science 316:1148-53. 2007
    ..Probing adhesion receptors on strategically engineered cells with force during functional stimulation can reveal key nodes of communication between the mechanical and chemical circuitry of a cell...
  92. pmc Performance of a lookup table-based approach for measuring tissue optical properties with diffuse optical spectroscopy
    Brandon S Nichols
    The University of Texas at Austin, Department of Biomedical Engineering, Austin, TX 78712, USA
    J Biomed Opt 17:057001. 2012
    ..Finally, we describe the rapid fabrication of a lookup table using only six calibration standards. This optimized LUT was able to extract scattering and absorption properties with average RMS errors of 2.5 and 4 percent, respectively...
  93. ncbi Hyperspectral imaging with scanning near-field optical microscopy: applications in plasmonics
    J S Bouillard
    Centre for Nanostructured Media, IRCEP, The Queen s University of Belfast, Belfast BT7 1NN, United Kingdom
    Opt Express 18:16513-9. 2010
    ..g., in the case of plasmonic nanostructures. Several example applications of hyperspectral near-field imaging are given for visualisation of Bloch modes in plasmonic crystals and plasmon-assisted transmission through a slit...
  94. ncbi Relevance of aerosol size spectrum analysis as support to qualitative source apportionment studies
    M Manigrasso
    DIPIA, INAIL ex ISPESL, Rome, Italy
    Environ Pollut 170:43-51. 2012
    ..Dust models and backward trajectories analysis confirmed such results, indicating the air mass provenience...
  95. ncbi An adaptive singular spectrum analysis approach to murmur detection from heart sounds
    Saeid Sanei
    School of Engineering and Physical Sciences, University of Surrey, Guildford, UK
    Med Eng Phys 33:362-7. 2011
    ..Singular spectrum analysis (SSA) has been adapted to the changes in the statistical properties of the data and effectively used for ..
  96. ncbi Signal source separation in the analysis of neural activity in brain
    Y Zheng
    Department of Psychiatry, University of Sheffield, Longley Centre, Sheffield S5 7JT, United Kingdom
    Neuroimage 13:447-58. 2001
    ..H. Chen-Bee et al. (1996b, J. Neurosci. Methods 68:28-37; C. H. Chen-Bee et al., 2000, J. Neurosci. Methods 97:157-173)...
  97. ncbi Complex-field measurement of ultrafast dynamic optical waveforms based on real-time spectral interferometry
    Mohammad H Asghari
    Institut National de la Recherche Scientifique Energie, Materiaux et Telecommunications, Montreal, Quebec H5A 1K6, Canada
    Opt Express 18:16526-38. 2010
    ..This performance is achieved at a measurement update rate of approximately 17 MHz, i.e. at least one thousand times faster than with any previous single-shot complex-field THz-bandwidth optical signal characterization method...
  98. ncbi Exciton analysis in 2D electronic spectroscopy
    Minhaeng Cho
    Department of Chemistry and Center for Multidimensional Spectroscopy, Division of Chemistry and Molecular Engineering, Korea University, Seoul 136 701, Korea
    J Phys Chem B 109:10542-56. 2005
    ..We find that there are two noncascading exciton energy relaxation pathways...
  99. ncbi Subsystem-based theoretical spectroscopy of biomolecules and biomolecular assemblies
    Johannes Neugebauer
    Gorlaeus Laboratories, Leiden Institute of Chemistry, Leiden University, P O Box 9502, 2300 RA Leiden, The Netherlands
    Chemphyschem 10:3148-73. 2009
    ..Connections to physical model theories are also outlined. Prototypical applications to optical spectra and excited states of fluorescent proteins, biomolecular photoreceptors, and photosynthetic protein complexes are discussed...
  100. ncbi High-rate x-ray spectroscopy in mammography with a CdTe detector: a digital pulse processing approach
    L Abbene
    Dipartimento di Fisica e Tecnologie Relative, Universita di Palermo, Viale delle Scienze, Edificio 18, Palermo 90128, Italy
    Med Phys 37:6147-56. 2010
    ..In this work we present a detection system, based on a CdTe detector and an innovative digital pulse processing (DPP) system, for high-rate x-ray spectroscopy in mammography...
  101. pmc Anatomy-based algorithms for detecting oral cancer using reflectance and fluorescence spectroscopy
    Sasha McGee
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge 02139, USA
    Ann Otol Rhinol Laryngol 118:817-26. 2009
    ..We designed diagnostic algorithms to account for differences in the spectral properties among anatomic sites (gingiva, buccal mucosa, etc)...

Research Grants63

  1. Regulation of SirT1 by Deleted in Breast Cancer 1 (DBC1)
    Zhenkun Lou; Fiscal Year: 2013
    ..Through tandem affinity purification and mass spectrum analysis, we have identified deleted in breast cancer-1 (DBC1) as a SirT1- associated protein...
  2. ESTROGEN AND THE AGING BRAIN
    John H Morrison; Fiscal Year: 2013
    ..We will pursue a full spectrum analysis of the key issues;from signaling mechanisms of estrogen to an in-depth structural and functional assessment ..
  3. Multimodal Imaging of Executive and Reward Networks Across the Psychosis Spectrum
    KATHERINE HELEN KARLSGODT; Fiscal Year: 2013
    ..We will further test whether a traditional categorical analysis or our symptom spectrum analysis can account for more of the variance in the structural measures...
  4. Imaging of Intrinsic Connectivity Networks
    Nan kuei Chen; Fiscal Year: 2013
    ..related distortions and intra-scan pulsation artifacts can be eliminated with an improved k-space energy spectrum analysis and a novel multi-band imaging scheme with location-dependent temporal-resolution, respectively;3) ..
  5. Myelin-Specific Diffusion Tensor Imaging for Developmental Neuroimaging
    Allen W Song; Fiscal Year: 2010
    ..spatial accuracy and low motion sensitivity using k-space acquisition in sparse matrix (kSPA) and energy spectrum analysis (KESA);2) develop a magnetization transfer contrast prepared, stimulated-echo DTI to sensitively image ..
  6. Applying Computational Linguistics to Fundamental Components of Schizophrenia
    Michael T Compton; Fiscal Year: 2013
    ..relation to disorganized symptoms;(2) examine phonetic linguistic parameters using computerized Fourier spectrum analysis of speech, and assess their relation to negative symptoms;(3) determine the combination of psycholinguistic ..
  7. Acoustic Trapping of Small Biological Particles
    K Kirk Shung; Fiscal Year: 2013
    ..method of acoustic tweezers is presented and two methods, using such as viscous drag force and power spectrum analysis, are described, and their results will be compared to check the accuracy of both approaches...
  8. Ultrasonic Tissue-Typing-Guided Prostate Brachytherapy
    Tian Liu; Fiscal Year: 2010
    ..cancerous regions within the prostate gland using an ultrasonic tissue-typing (UTT) technique based on 2-D spectrum analysis. Ultrasound data from 100 prostate cancer patients will be analyzed to create 3-D cancer maps...
  9. Molecular Pathophysiology of Human Growth Disorders
    MICHAEL WAJNRAJCH; Fiscal Year: 2002
    ..A novel aspect of this grant is the full spectrum analysis of these subjects-proceeding from patient to hormones to DNA to cell system...
  10. PEPTIDE REGULATION OF THE CHOROID PLEXUS-CSF SYSTEM
    Conrad Johanson; Fiscal Year: 2002
    ..Consequently, the three CP models, investigated with several methodologies, will enable a broad-spectrum analysis of how FGF-2, AVP, NO and other agent interact to regulate CP secretion...
  11. NOVEL ULTRASONIC IMAGING OF BRACHYTHERAPY SEEDS
    ERNEST FELEPPA; Fiscal Year: 2000
    ..These methods include spectrum analysis of radio-frequency ultrasonic echo signals, elastographic analysis, and harmonic-signal analysis; all can ..
  12. Maximum Entropy Deconvolution for Resolution &Sensitivity Enhancement in Bio-NMR
    Jeffrey C Hoch; Fiscal Year: 2013
    ..Nonlinear methods of spectrum analysis can in some cases avoid this tradeoff, and simultaneously improve both sensitivity and resolution...
  13. Random Phase Detection for Accelerating Biomolecular NMR Experiments
    Jeffrey C Hoch; Fiscal Year: 2013
    ..By employing non- Fourier methods of spectrum analysis that do not require data to be sampled at uniform intervals, it is becoming possible to achieve much higher ..
  14. K-Space energy spectrum analysis for echo-planar imaging
    Nan kuei Chen; Fiscal Year: 2007
    ..Here we propose to use a novel k-space energy spectrum analysis to quantify (1) the k-space energy distribution, (2) susceptibility field gradients, (3) the spatially-..
  15. RECURRENT CAROTID STENOSIS
    EUGENE BERNSTEIN; Fiscal Year: 1990
    ..institution who were followed both angiographically and noninvasively with B-mode imaging and pulsed Doppler spectrum analysis showed very good sensitivity and specificity for the non-invasive procedures, and documented recurrent ..
  16. Ocular Control of Melatonin Regulation: Action Spectrum
    George Brainard; Fiscal Year: 2004
    ..The primary technique to accomplish this aim will be action spectrum analysis. An action spectrum: 1) defines the relative effectiveness of wavelengths for eliciting a biological ..
  17. ULTRASONIC CHARACTER OF CAROTID PLAQUE CONSTITUENTS
    Andrew Roberts; Fiscal Year: 2001
    ..A UTC methodology developed by RRI employing quantitative spectrum analysis of backscattered echoes will be further tailored and refined for carotid plaque applications...
  18. UltraScan Software Maintenance and Development
    Borries Demeler; Fiscal Year: 2010
    ..parallel computation of Monte Carlo approaches, genetic algorithm optimizations, and the 2-dimensional spectrum analysis. Further, we propose to develop novel approaches for improved nonlinear least squares optimization, to port ..
  19. CRYO FREE 47T ACTIVE SHIELDED ICR SPECTROMETER MAGNET
    Weijun Shen; Fiscal Year: 1999
    ..The proposed magnet system will be ideal for bio-laboratories to perform spectrum analysis where and when access to liquid cryogens is limited, or where the laboratory space is limited...
  20. CRYO-FREE 4.7 ACTIVE-SHEILD ICR SPECTROMETER MAGNET
    EARLE BURKHARDT; Fiscal Year: 2001
    ..The proposed magnet system will be ideal for bio-laboratories performing spectrum analysis where and when access to liquid cryogen is limited, or where the laboratory space is limited...
  21. MOLECULAR MODELING, DESIGN, & EVALUATION OF BDZ LIGANDS
    TIMOTHY DELOREY; Fiscal Year: 2000
    ..of the number central BDZR subtypes in several additional brain regions using Fourier-derived affinity spectrum analysis used to successfully characterize receptor heterogeneity in spinal cord during the current grant period and ..
  22. REAL-TIME ULTRASONIC TISSUE IMAGING FOR PROSTATE CANCER
    Richard Bernardi; Fiscal Year: 2000
    ..This color-encoding will be based on spectrum analysis of ultrasonic rf echo signals...
  23. ULTRASONIC CONTRAST METHODS--PERFUSION QUANTIFICATION
    Cheri Deng; Fiscal Year: 2001
    ..Calibrated spectrum analysis of radio-frequency (rf) echo signals will be used to measure the effective concentrations of contrast agents...
  24. ADVANCED AT HOME SCREENING DEVICE FOR SLEEP APNEA
    ARTHUR COOKE; Fiscal Year: 2000
    ..Active Signal will measure sleep quality using sophisticated power spectrum analysis on high fidelity detected signals to recognize and count subtle breathing ,body motion, and cardiovascular ..
  25. ULTRASONIC EVALUATION OF OCULAR TISSUES
    ERNEST FELEPPA; Fiscal Year: 2007
    ..They will extract detailed tissue information from regions inaccessible to other imaging modalities. The methods will be clinically evaluated in cases of age-related macular generation. ..
  26. ULTRASONIC EVALUATION OF OCULAR TISSUES
    ERNEST FELEPPA; Fiscal Year: 2001
    ..Effects of glaucoma medication will be quantified. Simplified, standardized output formats of useful parameters will be derived to foster use of these techniques in ophthalmology. ..
  27. Validation and Extension of the Theory of Ultrasound Scattering in Tissue
    ERNEST FELEPPA; Fiscal Year: 2008
    ..g., differences between normal and diseased or damaged tissue. [unreadable] [unreadable] [unreadable]..
  28. INTEGRATED ULTRASONIC SYSTEMS FOR NONINVASIVE THERAPY
    ERNEST FELEPPA; Fiscal Year: 2005
    ..Results are expected to be incorporated in a systems model of ultrasonic therapy which would permit comprehensive treatment planning and design of future system features. ..
  29. NOVEL ULTRASONIC IMAGING OF BRACHYTHERAPY SEEDS
    ERNEST FELEPPA; Fiscal Year: 2007
    ..Technical support in the form of consulting, software, seeds, etc., will be provided by Varian Medical Systems, Inc., which offers a potential path for translating the research results into a commercial product. ..
  30. CLINICAL ULTRASONIC CHARACTERIZATION OF THE PROSTATE
    ERNEST FELEPPA; Fiscal Year: 2004
    ..demonstrated the feasibility of differentiating cancerous from non-cancerous tissues of the prostate using spectrum analysis of radio-frequency ultrasonic echo signals...
  31. ULTRASONIC SAFETY AND THERAPY IN OPHTHAMALOGY
    ERNEST FELEPPA; Fiscal Year: 2004
    ..Safety will be determined using calibrated exposures in in-vivo animal eyes and comprehensive follow-up examinations. Results will be disseminated to support continued safety as new systems evolve. ..
  32. Ultrasonic BioMicroscopy Conference 2004
    ERNEST FELEPPA; Fiscal Year: 2004
    ..acoustic cell microscopy; complementary highresolution modalities (e.g., OCT, special MRI units). Thus the meeting should be of direct interest to various braches of NIH including NIBIB, NCI, NHLBI, and NEI. ..
  33. Very-High-Frequency Ultrasound Imaging With Coded Signals and Annular Arrays
    Jonathan Mamou; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  34. Folding and Assembly of Ankyrin Repeat Proteins
    Jeffrey Hoch; Fiscal Year: 2006
    ..Taken together, these combined approaches will generate important information regarding the folding of multiple repeat proteins and how the structural and folding abnormalities may underline serious human diseases. ..
  35. Signal processing software for biomolecular NMR
    Jeffrey Hoch; Fiscal Year: 2008
    ..A number of modern methods of spectrum analysis have been developed that avoid these shortcomings, but they have not found routine application in NMR...
  36. An Open-access 800 MHz NMR Spectrometer for Central New England
    Jeffrey Hoch; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  37. Prostate Edema in Permanent Interstitial Brachytherapy
    Zhe Chen; Fiscal Year: 2010
    ..The primary objective of this project is to develop a new method to consider the effects of edema in radiation dosimetry and treatment planning so that the efficacy of this therapy can be optimized for each patient. ..
  38. Neural Mechanisms of Selectively Biasing Attentional Set
    John Foxe; Fiscal Year: 2003
    ....
  39. NITROXIDERGIC CEREBROVASCULAR TONE DURING ANESTHESIA
    Shailendra Joshi; Fiscal Year: 2005
    ..abstract_text> ..
  40. ADVERSE EARLY REARING & GLUTAMATERGIC FUNCTION
    Jeremy Coplan; Fiscal Year: 2003
    ..Ongoing neurochemical and behavioral assessments will provide extensive longitudinal documentation of the effects of such reductions. ..
  41. Daily Activity of TKR Patients as Input for Wear Testing
    Markus Wimmer; Fiscal Year: 2008
    ..Based on the kinematic and kinetic in vivo data derived in the motion laboratory, we will calculate contact forces using a mathematical model of the artificial knee. [unreadable] [unreadable] [unreadable]..
  42. Optical Spectroscopy for Management of Cancer Treatment
    Irving Bigio; Fiscal Year: 2007
    ..The Administrative Core provides the superstructure of the Team, especially to facilitate communication and information sharing, both within this Team and among all the Teams of the Network. ..
  43. OXYGEN DOSIMETRY IN PHOTODYNAMIC THERAPY
    Brian Pogue; Fiscal Year: 2001
    ..abstract_text> ..
  44. SINGLE-MOLECULE ANALYSIS OF A TRANSCRIPTION ENHANCER
    Larry Friedman; Fiscal Year: 2006
    ..The single-molecule approach will highlight relations between the mechanisms at successive steps, thus contributing to an integrated description of the enhancer-mediated initiation process in this model system. ..
  45. A new general methodology for studying conformational dynamics in single cells
    Marcia Levitus; Fiscal Year: 2008
    ..Understanding chromatin dynamics is a key step in the process of elucidating the mechanisms of development, differentiation and cancer. [unreadable] [unreadable] [unreadable]..
  46. Optical Measurement of Fast Drug Kinetics in Tumor
    Irving Bigio; Fiscal Year: 2006
    ..Such application of the OP method can result in improved management of treatment in humans, especially for superficial lesions in which kinetics are difficult to assess by current imaging methods. ..
  47. Power Harvesting in Implanted Neural Probes
    Nitish Thakor; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  48. Cognitive Control in Aging
    John Foxe; Fiscal Year: 2004
    ..High-density ERP recordings and topographic mapping will permit us to assess the relative contributions of frontal, parietal and earlier sensory areas to these processes. ..
  49. ACOUSTIC CORRELATES OF PHONETIC PERCEPTION
    James Hillenbrand; Fiscal Year: 2007
    ..A software simulation will be developed for use in testing the validity of the theory. ..
  50. Multifunction Sensing and Imaging in Brain Tissue Slice
    Nitish Thakor; Fiscal Year: 2003
    ..abstract_text> ..
  51. Quantitative Electrical Measure of Brain Injury
    Nitish Thakor; Fiscal Year: 2005
    ..The significance of this project primarily lies in developing a novel quantitative tool that can benefit basic and clinical scientists studying brain injury. ..
  52. Ultrafast Electron Cryomicroscopy of Single Protein Particles
    Ahmed H Zewail; Fiscal Year: 2010
    ..If successful, this advance could make structure determination to near-atomic resolution routine for large macromolecular complexes. ..
  53. Neutron Microscope for In-Vivo Imaging
    JAY CREMER; Fiscal Year: 2005
    ..abstract_text> ..
  54. Optical Scatter Microscopy
    NADA BOUSTANY; Fiscal Year: 2002
    ..In this initial phase of development, the investigators will use OSM to study mitochondrial dysfunction during cell death. The long-term goal is to develop OSM as a tool for functional microscopy. ..
  55. QEEG and qSpike: brain indicator of temperature manipulation after cardiac arrest
    Nitish Thakor; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  56. Neurophysiology of Multisensory Integration
    John Foxe; Fiscal Year: 2007
    ..Through these studies, we will begin to explore the neural mechanisms underlying the process of "binding," related inputs across the separate sensory modalities. ..
  57. Age, Physical Activity, Genotype and Cognitive Function
    BRADLEY HATFIELD; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  58. STRUCTURE/FUNCTION AND REACTION MECHANISM OF PGHS
    Ah Lim Tsai; Fiscal Year: 2008
    ..The last aim will provide direct data on the membrane topology of PGHS and the mechanism of its substrate presentation and product release. [unreadable] [unreadable]..
  59. Bilirubin and Photobilirubin: Metabolism & Exretion
    Antony McDonagh; Fiscal Year: 2005
    ..The work will lead to safer more effective treatment of familial hyperbilirubinemia and jaundice in the newborn. ..
  60. Optic Imaging of Fast Neural Activation Patterns in Brain Tissue
    Irving Bigio; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  61. Luminescence Studies of Lanthanide Contrast Agents
    JANET MORROW; Fiscal Year: 2006
    ..The new laser system will also be available to researchers throughout the country and will be at the heart of a center for Ln(lll) luminescence research. [unreadable] [unreadable] [unreadable]..
  62. CELL SURVIVAL IN A NEURAL CIRCUIT FOR LEARNING
    Wei Wu; Fiscal Year: 2010
    ..1 ..
  63. Integrated electrochemical microsensor array
    Nitish Thakor; Fiscal Year: 2002
    ..The coupling of these two basic neural responses, electrical and chemical, would shift the prevailing paradigm of neuroscience research pertaining to neurological diseases or mental health. ..