infrared spectrophotometry

Summary

Summary: Spectrophotometry in the infrared region, usually for the purpose of chemical analysis through measurement of absorption spectra associated with rotational and vibrational energy levels of molecules. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

Top Publications

  1. ncbi Development of biomimetic nano-hydroxyapatite/poly(hexamethylene adipamide) composites
    Xuejiang Wang
    Institute of Materials Science and Technology, Sichuan University, 610064 Chengdu, China
    Biomaterials 23:4787-91. 2002
  2. ncbi The infrared absorption of amino acid side chains
    A Barth
    Institut fur Biophysik, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, Haus 74, D 60590 Frankfurt am Main, Germany
    Prog Biophys Mol Biol 74:141-73. 2000
  3. ncbi Structure and dynamics of membrane proteins as studied by infrared spectroscopy
    J L Arrondo
    Unidad de Biofisica Centro Mixto CSIC UPV EHU, Bilbao, Spain
    Prog Biophys Mol Biol 72:367-405. 1999
  4. ncbi Resonant Mie scattering in infrared spectroscopy of biological materials--understanding the 'dispersion artefact'
    Paul Bassan
    School of Chemical Engineering and Analytical Science, Manchester Interdisciplinary Biocentre, The University of Manchester, 131 Princess Street, Manchester, UK M1 7DN
    Analyst 134:1586-93. 2009
  5. ncbi Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects
    Weibo Cai
    Molecular Imaging Program MIPS, Department of Radiology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nano Lett 6:669-76. 2006
  6. ncbi Regional differences of hemodynamics and oxygenation in the human calf muscle detected with near-infrared spectrophotometry
    Ursula Wolf
    Laboratory for Fluorescence Dynamics, Biomedical Engineering Department, University of California Irvine, 3120 Natural Sciences II Bldg, Irvine, CA 92697 2715, USA
    J Vasc Interv Radiol 18:1094-101. 2007
  7. ncbi The influence of a clear layer on near-infrared spectrophotometry measurements using a liquid neonatal head phantom
    M Wolf
    Clinic for Neonatology, University Hospital, Zurich, Switzerland
    Phys Med Biol 44:1743-53. 1999
  8. ncbi Efforts toward developing direct probes of protein dynamics
    Matthew E Cremeens
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Am Chem Soc 128:6028-9. 2006
  9. ncbi The 2D IR responses of amide and carbonyl modes in water cannot be described by Gaussian frequency fluctuations
    Yung Sam Kim
    J Phys Chem B 111:9697-701. 2007
  10. ncbi Determination of conformational preferences of dipeptides using vibrational spectroscopy
    Joze Grdadolnik
    National Institute of Chemistry, Hajdrihova 19, SI 1000 Ljubljana, Slovenia
    J Phys Chem B 112:2712-8. 2008

Research Grants

Detail Information

Publications220 found, 100 shown here

  1. ncbi Development of biomimetic nano-hydroxyapatite/poly(hexamethylene adipamide) composites
    Xuejiang Wang
    Institute of Materials Science and Technology, Sichuan University, 610064 Chengdu, China
    Biomaterials 23:4787-91. 2002
    ..Chemical binding between inorganic n-HA and polyamide was investigated and discussed. The mechanical properties of the composites were found to match well with those of natural bone...
  2. ncbi The infrared absorption of amino acid side chains
    A Barth
    Institut fur Biophysik, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, Haus 74, D 60590 Frankfurt am Main, Germany
    Prog Biophys Mol Biol 74:141-73. 2000
    ..To help the interpretation of the spectra, a review of the infrared absorption of amino acid side chains in H(2)O and 2H(2)O is given. The spectral region of 2600-900cm(-1) is covered...
  3. ncbi Structure and dynamics of membrane proteins as studied by infrared spectroscopy
    J L Arrondo
    Unidad de Biofisica Centro Mixto CSIC UPV EHU, Bilbao, Spain
    Prog Biophys Mol Biol 72:367-405. 1999
    ..In addition, shorter descriptions of retinal proteins and references to other membrane proteins that have been studied less extensively are also included...
  4. ncbi Resonant Mie scattering in infrared spectroscopy of biological materials--understanding the 'dispersion artefact'
    Paul Bassan
    School of Chemical Engineering and Analytical Science, Manchester Interdisciplinary Biocentre, The University of Manchester, 131 Princess Street, Manchester, UK M1 7DN
    Analyst 134:1586-93. 2009
    ....
  5. ncbi Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects
    Weibo Cai
    Molecular Imaging Program MIPS, Department of Radiology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nano Lett 6:669-76. 2006
    ..The results reported here open up new perspectives for integrin-targeted near-infrared optical imaging and may aid in cancer detection and management including imaging-guided surgery...
  6. ncbi Regional differences of hemodynamics and oxygenation in the human calf muscle detected with near-infrared spectrophotometry
    Ursula Wolf
    Laboratory for Fluorescence Dynamics, Biomedical Engineering Department, University of California Irvine, 3120 Natural Sciences II Bldg, Irvine, CA 92697 2715, USA
    J Vasc Interv Radiol 18:1094-101. 2007
    ..This, however, may not be the case. The study was performed to investigate whether this hypothesis is true for hemodynamics and oxygenation in the healthy human calf muscle at rest...
  7. ncbi The influence of a clear layer on near-infrared spectrophotometry measurements using a liquid neonatal head phantom
    M Wolf
    Clinic for Neonatology, University Hospital, Zurich, Switzerland
    Phys Med Biol 44:1743-53. 1999
    It is difficult to test near-infrared spectrophotometry instruments in vivo. Therefore we constructed a liquid phantom which mimics the neonatal head. It consists of a spherical 3...
  8. ncbi Efforts toward developing direct probes of protein dynamics
    Matthew E Cremeens
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Am Chem Soc 128:6028-9. 2006
    ....
  9. ncbi The 2D IR responses of amide and carbonyl modes in water cannot be described by Gaussian frequency fluctuations
    Yung Sam Kim
    J Phys Chem B 111:9697-701. 2007
    ..The results suggest new approaches to examine protein-bound water at the residue level...
  10. ncbi Determination of conformational preferences of dipeptides using vibrational spectroscopy
    Joze Grdadolnik
    National Institute of Chemistry, Hajdrihova 19, SI 1000 Ljubljana, Slovenia
    J Phys Chem B 112:2712-8. 2008
    ..The population of the beta conformation increases in valine dipeptides. The populations of the alpha(R) conformation are generally small. These data are in accord with the electrostatic screening model of conformational preferences...
  11. ncbi Localized irregularities in hemoglobin flow and oxygenation in calf muscle in patients with peripheral vascular disease detected with near-infrared spectrophotometry
    Ursula Wolf
    Laboratory for Fluorescence Dynamics, Department of Physics, University of Illinois at Urbana Champaign, USA
    J Vasc Surg 37:1017-26. 2003
    Near-infrared spectrophotometry is used to measure flow, concentration, and oxygenation of hemoglobin in arterioles, capillaries, and venules several centimeters deep in tissue...
  12. ncbi Nitrile groups as vibrational probes of biomolecular structure and dynamics: an overview
    Beth A Lindquist
    Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA
    Phys Chem Chem Phys 11:8119-32. 2009
    ..A strong synergy between experiment and theory will further promote the use of vibrational spectroscopy of nitrile-labeled biomolecules to address fundamental questions of structure and dynamics that are elusive to other techniques...
  13. pmc Site-specific conversion of cysteine thiols into thiocyanate creates an IR probe for electric fields in proteins
    Aaron T Fafarman
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
    J Am Chem Soc 128:13356-7. 2006
    ..Vibrational Stark effect spectroscopy and Fourier transform infrared spectroscopy on the modified proteins demonstrated that thiocyanate residues are a highly general tool for probing electrostatic fields in proteins...
  14. pmc Infrared micro-spectroscopic studies of epithelial cells
    Melissa Romeo
    Department of Chemistry and Biochemistry, City University of New York, Hunter College, New York, NY 10021, USA
    Biochim Biophys Acta 1758:915-22. 2006
    ..Since this report is written for an audience not familiar with infrared micro-spectroscopy, a short introduction into this field is presented along with a summary of principal component analysis...
  15. ncbi IR microspectroscopy: potential applications in cervical cancer screening
    Michael J Walsh
    Biomedical Sciences Unit, Department of Biological Sciences, Lancaster University, Lancaster, UK
    Cancer Lett 246:1-11. 2007
    ..An increasing wealth of literature points to the ability of IR microspectroscopy to allow the segregation of cells based on their disease status. We review the current evidence supporting its diagnostic potential in cancer biology...
  16. ncbi Classification of signatures of Bovine Spongiform Encephalopathy in serum using infrared spectroscopy
    T C Martin
    Roche Diagnostics GmbH, Sandhofer Str 116, 68305 Mannheim, Germany
    Analyst 129:897-901. 2004
    ..To the best of our knowledge, DPR is the first and--up to now--only method which has demonstrated its capability of detecting BSE-related signatures in serum...
  17. ncbi IR spectroelectrochemical study of the binding of carbon monoxide to the active site of Desulfovibrio fructosovorans Ni-Fe hydrogenase
    Antonio L De Lacey
    Instituto de Catalisis, CSIC, Campus Universidad Autonoma Cantoblanco, Madrid 28049, Spain
    J Biol Inorg Chem 7:318-26. 2002
    ..A calculated structure with a weakly bound extrinsic CO at Ni has relative CO frequencies in excellent agreement with the experimental ones...
  18. ncbi Preparation and microstructure analysis of chitosan/hydroxyapatite nanocomposites
    I Yamaguchi
    National Institute for Research in Inorganic Materials, Tsukuba, Ibaraki, Japan
    J Biomed Mater Res 55:20-7. 2001
    ..The compact composites obtained have been found to be mechanically flexible, and this flexibility has been improved further by heating at 120 degrees C for 20 min in an autoclave with saturated steam pressure...
  19. ncbi Infrared studies on the interaction of carbon monoxide with divalent nickel in hydrogenase from Chromatium vinosum
    K A Bagley
    Isotope and Nuclear Chemistry Division, INC 14, C 345 Los Alamos National Laboratory, New Mexico 87545
    Biochemistry 33:9229-36. 1994
    ..It is concluded that these non-CO bands arise from species near or coordinated to the Ni active site. The possible nature of these bands is discussed...
  20. ncbi Development of infrared imaging to measure thermogenesis in cell culture: thermogenic effects of uncoupling protein-2, troglitazone, and beta-adrenoceptor agonists
    M A Paulik
    Department of Metabolic Diseases, GlaxoWellcome Inc, Research Triangle Park, North Carolina 27709, USA
    Pharm Res 15:944-9. 1998
    ..In this report, we describe a robust non-invasive technique to measure real-time thermogenesis of cells cultured in microtiter plates using infrared thermography...
  21. ncbi A high-resolution probe of protein folding
    Laura B Sagle
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California, 92037, USA
    J Am Chem Soc 126:3384-5. 2004
    ....
  22. pmc Rationally selected basis proteins: a new approach to selecting proteins for spectroscopic secondary structure analysis
    Keith A Oberg
    Structural Biology and Bioinformatics Center, Structure and Function of Biological Membranes Laboratory, Free University of Brussels ULB, B 1050 Brussels, Belgium
    Protein Sci 12:2015-31. 2003
    ....
  23. ncbi Induction of secondary structure in a COOH-terminal peptide of histone H1 by interaction with the DNA: an infrared spectroscopy study
    R Vila
    Departamento de Bioquimica y Biologia Molecular, Facultad de Ciencias, , 08193 Bellaterra, Barcelona, Spain
    J Biol Chem 276:30898-903. 2001
    ..Both components are inside the spectral region of alpha-helical structures. Our results support the presence of inducible helical and turn elements, both sharing the character of DNA-binding motifs...
  24. ncbi IR study of cross-strand coupling in a beta-hairpin peptide using isotopic labels
    Vladimir Setnicka
    Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, Illinois 60607 7061, USA
    J Am Chem Soc 127:4992-3. 2005
    ..The thermal behavior of both peptides yields a broad thermal transition and lacks an isosbestic point. The 13C band for HBG-L has the largest intensity change with temperature, distinct from the 12C change and the HBG-S 13C change...
  25. ncbi Probing the effect of side chains on the conformation and stability of helical peptides via isotope-edited infrared spectroscopy
    R A Gangani D Silva
    Department of Chemistry, Mount Holyoke College, South Hadley, Massachusetts 01075, USA
    Biochemistry 41:15296-303. 2002
    ..These experiments demonstrate the power of isotope-edited IR in dissecting subtle changes in helix conformation at the residue level...
  26. ncbi A new method for determining the local environment and orientation of individual side chains of membrane-binding peptides
    Matthew J Tucker
    Department of Chemistry, University of Pennsylvania, Philadelphia, 19104 USA
    J Am Chem Soc 126:5078-9. 2004
    ..We have also shown that polarized ATR-FTIR measurements can further be used to uncover information regarding the spatial orientation of individual side chains as well as their conformational preference within the lipid bilayer...
  27. ncbi The optimization of protein secondary structure determination with infrared and circular dichroism spectra
    Keith A Oberg
    Center for Structural Biology and Bioinformatics, Laboratory for the Structure and Function of Biological Membranes, Free University of Brussels ULB, Belgium
    Eur J Biochem 271:2937-48. 2004
    ..Interestingly, it was also found in the course of this study that the amide II band has high information content and could be used alone for secondary structure prediction in place of amide I...
  28. pmc Monitoring cell cycle distributions in MCF-7 cells using near-field photothermal microspectroscopy
    Azzedine Hammiche
    Department of Physics, Institute of Environmental and Natural Sciences, Lancaster University, Lancaster, United Kingdom
    Biophys J 88:3699-706. 2005
    ..These results seem to suggest that intracellular bulk changes, associated with transit through the cell cycle, can be tracked using PTMS...
  29. ncbi In situ surface-enhanced infrared study of hydrogen bond pairing of complementary nucleic acid bases at the electrochemical interface
    Yukari Sato
    National Institute of Advanced Industrial Science and Technology, 1 1 1 Higashi, Central 6, Tsukuba, Ibaraki 305 8566, Japan
    Anal Chem 76:5564-9. 2004
    ..Due to steric hindrance, an adenine-thymine-type hydrogen bond pair is formed only at potentials more positive than 0.1 V (vs SCE) where the unprotonated adenine moiety is perpendicularly oriented...
  30. ncbi Bedside functional imaging of the premature infant brain during passive motor activation
    S R Hintz
    Biomedical Optics Group, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Hansen Physics Laboratory, Palo Alto, California, USA
    J Perinat Med 29:335-43. 2001
    ..Imaging methods, which use near-infrared light allow for non-invasive measurements by taking advantage of the fact that hemoglobin is a strong absorber at these wavelengths...
  31. ncbi Preparation of new nitrogen-bridged heterocycles. 58. Syntheses and intramolecular arene-pi interactions of 3-(allylthio)- and 3-(propargylthio)thieno[3,4-b]indolizine derivatives
    Akikazu Kakehi
    Department of Chemistry and Material Engineering, Faculty of Engineering, Shinshu University, Nagano, Japan
    Chem Pharm Bull (Tokyo) 53:1430-8. 2005
    ..Furthermore, both types of gauche conformations in which the intramolecular arene-pi interactions are possible in one form and impossible in the other were confirmed by X-ray analyses of some compounds...
  32. ncbi Classification of conformation for sugar amino acid systems using chiroptical spectroscopy
    Alison A Edwards
    Biological Chemistry, Division of Biomedical Sciences, Imperial College, London, United Kingdom
    Chirality 18:265-72. 2006
    ..A set of tetrameric SAAs are examined and the effect of change in primary structure related to conformation...
  33. ncbi Optical spectra of a novel polyoxometalate occluded within modified MCM-41
    Xiaoming Zhang
    Center for Analysis of Structures and Interfaces CASI, Department of Chemistry, The City College of The City University of New York CUNY, New York, New York 10031, USA
    J Phys Chem B 109:19156-60. 2005
    ..A strong photoluminescence suggests the potential utility of the polyoxometalate as a luminescent material...
  34. ncbi How to model solvation of peptides? Insights from a quantum-mechanical and molecular dynamics study of N-methylacetamide. 1. Geometries, infrared, and ultraviolet spectra in water
    Benedetta Mennucci
    Dipartimento di Chimica e Chimica Industriale, Universita di Pisa, Via Risorgimento 35, 56126 Pisa, Italy
    J Phys Chem B 109:9818-29. 2005
    ....
  35. ncbi Normal coordinate analyses of 3,5-dichlorophenylcyanamide
    Hassan M Badawi
    Department of Chemistry, King Fahd University of Petroleum and Minerals, 31261 Dhahran, Saudi Arabia
    J Mol Model 10:178-84. 2004
    ..The calculated infrared and Raman spectra of the molecule were plotted. Complete vibrational assignments were made on the basis of isotopic substitution and normal coordinate calculations...
  36. ncbi Two new scorpionates vanadium haloperoxidases model complexes: synthesis and structure of VO(O2)(pzH)(HB(pz)3) and VO(O2)(pzH)(B(pz)4) (pzH = pyrazole(C3H4N2))
    Yongheng Xing
    Bioinorganic Laboratory, Liaoning Normal University, Dalian 116029, PR China
    J Inorg Biochem 101:36-43. 2007
    ..In the concentration range (0.1-100mumol), both complexes have an inhibiting cellular proliferation effect. When the cells cultivated with the complexes at high dose, the toxicity effect of both complexes is more and more predominant...
  37. ncbi [Derivatives of exemestane--synthesis and evaluation of aromatase inhibition]
    K Görlitzer
    Institut für Pharmazeutische Chemie Analytische Chemie der Technischen Universität Braunschweig, Germany
    Pharmazie 61:575-81. 2006
    ..91 microM; 10, 2.5 microM; 11, 10 microM) compared to 6 (IC50 = 0.23 microM). The 1,4-DHP 11 was dehydrogenated with CAN or electrochemically (E1/2 =1.18 V) to yield the corresponding pyridine 12...
  38. ncbi Fourier transform infrared and Raman spectra, vibrational assignment and density functional theory calculations of naphthazarin
    Mansoureh Zahedi Tabrizi
    Chemistry Department, Ferdowsi University, Mashhad 91775 1436, Iran
    Spectrochim Acta A Mol Biomol Spectrosc 60:111-20. 2004
    ..Two bands at about 350 and 290 cm(-1) are assigned to the O...O stretching modes belong to A1 and B2 species, respectively...
  39. ncbi Stacking effect of polyfluorene on the chemical shift and electron transport
    Woo Seong Kim
    Department of Chemistry, Chonnam National University, 300 Yongbong Dong, Bugku, Gwangju, 500 757, Korea
    J Phys Chem B 109:2686-92. 2005
    ..This was evident from the frontier molecular orbitals (HOMO and LUMO). Also, it is found that the syn conformers are very favorable for electron transport through the pi-stacked fluorene moieties...
  40. ncbi Preparation of new nitrogen-bridged heterocycles. 54.increased arene-arene interactions of 3-(bicyclic and tricyclic arylmethylthio)thieno[3,4-b]indolizine derivatives
    Akikazu Kakehi
    Department of Chemistry and Material Engineering, Faculty of Engineering, Shinshu University, Wakasato, Nagano, Japan
    Chem Pharm Bull (Tokyo) 51:1246-52. 2003
    ..In the X-ray analyses of some compounds, however, the presence of both the gauche and the anti conformers at the sulfide spacer were confirmed...
  41. ncbi Experimental and computational studies of structure and bonding in parent and reduced forms of the azo dye Orange II
    Laurence C Abbott
    Department of Chemistry, The University of York, Heslington, York YO10 5DD, UK
    J Phys Chem A 109:2894-905. 2005
    ....
  42. ncbi Helically chiral ferrocene peptides containing 1'-aminoferrocene-1-carboxylic acid subunits as turn inducers
    Lidija Barišić
    Faculty of Food Technology and Biotechnology, Pierottijeva 6, HR 10000 Zagreb, Croatia
    Chemistry 12:4965-80. 2006
    ..The systematic work described herein lays a solid foundation for the rational design of metallocene peptides with unusual structures and properties...
  43. ncbi Remarkably stereoselective photoinduced electron-transfer reaction between zinc myoglobin and optically active binaphthyl bisviologen
    Hiroshi Takashima
    Department of Chemistry, Faculty of Science, Nara Women s University, 630 8506, Nara, Japan
    J Biol Inorg Chem 8:499-506. 2003
    ..Therefore, the thermal ET reaction to the ground state was proved to be dominated by the entropy term, and the large stereoselectivity may arise from the decrease in charge repulsion between donor and acceptor...
  44. ncbi UV-vis, IR and 1H NMR spectroscopic studies of some 6-chloro,2-pyridyl hydrazones
    Raafat M Issa
    Chemistry Department, Faculty of Science, Tanta University, Tanta, Egypt
    Spectrochim Acta A Mol Biomol Spectrosc 65:206-14. 2006
    ..The geometry is optimized using the PM3 method...
  45. ncbi Three new types of indoloditerpenes, emindole PA-PC, from Emericella purpurea. Revision of the structure of emindole PA
    Tomoo Hosoe
    Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan
    Chem Pharm Bull (Tokyo) 54:185-7. 2006
    ..The structure of emindoles PA (1) was revised from our preliminary report. Emindoles PA (1), PB (2), and PC (3) are the indoloditerpenes having a new type of carbon skeleton...
  46. ncbi Vibrational assignment, structure and intramolecular hydrogen bond study of 3-amino-1-phenyl-2-buten-1-one
    Haidar Raissi
    Chemistry Department, Birjand University, Birjand 98178, Iran
    Spectrochim Acta A Mol Biomol Spectrosc 63:729-39. 2006
    ..These results also support the stronger hydrogen bond in the title compound with respect to the parent molecule...
  47. ncbi UV-vis, IR and 1H NMR spectroscopic studies of some mono- and bis-azo-compounds based on 2,7-dihydroxynaphthalene and aniline derivatives
    Raafat M Issa
    Chemistry Department, Faculty of Science, Tanta University, 31527 Tanta, Egypt
    Spectrochim Acta A Mol Biomol Spectrosc 62:980-6. 2005
    ..According to these calculations, an intramolecular hydrogen bonding is essential for stabilization of such molecules...
  48. ncbi Nickel (II) complexes of naphthaquinone thiosemicarbazone and semicarbazone: synthesis, structure, spectroscopy, and biological activity
    Zahra Afrasiabi
    Department of Chemistry, University of Missouri Rolla, Rolla, MO 65409, USA
    J Inorg Biochem 99:1526-31. 2005
    ..In vitro anticancer studies on MCF-7 human breast cancer cells reveal that the semicarbazone derivative along with its nickel complex is more active in the inhibition of cell proliferation than the thiosemicarbazone analogue...
  49. ncbi Proteins in action monitored by time-resolved FTIR spectroscopy
    Carsten Kötting
    Lehrstuhl fur Biophysik, ND 04 596, Ruhr Universitat Bochum, 44801 Bochum, Germany
    Chemphyschem 6:881-8. 2005
    ..The main principles of the technique are presented, including a summary of triggering techniques, scan modes and analysis...
  50. ncbi Heteroditopic ligand accommodating a fused phenanthroline and a schiff base cavity as molecular spacer in the study of electron and energy transfer
    Yann Pellegrin
    Laboratoire de Chimie Inorganique, UMR 8613, Universite de Paris Sud, Orsay, France
    Chemistry 11:3698-710. 2005
    ..Evidence is presented that this quenching is due to intramolecular electron transfer, at least in the case of [Ru(bpy)(2)(DPSalH(2))](2+), for which a charge-separated state with a remarkable lifetime of about 30 mus was observed...
  51. ncbi Expeditious syntheses of conjugated allenyl esters and oxazoles through a cascade reaction of alpha-alkynyl malonates under alkaline conditions
    Shigeki Sano
    Graduate School of Pharmaceutical Sciences, The University of Tokushima, Japan
    Chem Pharm Bull (Tokyo) 54:196-203. 2006
    ....
  52. ncbi Spectral and optical studies of 2-amino-5-nitropyridinium dihydrogen phosphate: a semiorganic nonlinear optical material
    A Pricilla Jeyakumari
    Department of Physics, Bharathidasan University, Tiruchirappalli 620 024, India
    Spectrochim Acta A Mol Biomol Spectrosc 67:83-6. 2007
    ..Bulk and powder second harmonic generation (SHG) measurements were carried out using Nd:YAG laser (lambda=1064 nm) and its phase matching condition was determined...
  53. ncbi Solid state characterization of olanzapine polymorphs using vibrational spectroscopy
    A P Ayala
    Department of Physical Chemistry, University of Duisburg Essen, Essen D45117, Germany
    Int J Pharm 326:69-79. 2006
    ..Our results support the hydrogen bonding pattern proposed by the reported crystalline structure and provide valuable information on the structural and thermodynamical relationship between the investigated polymorphs...
  54. ncbi Study on structure and characterization of inclusion complex of gossypol/beta cyclodextrin
    Ying lin Shen
    Department of Chemistry, National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China
    Spectrochim Acta A Mol Biomol Spectrosc 61:1025-8. 2005
    ..The association constant between gossypol and beta-cyclodextrin measured via UV spectroscopy was 4462M(-1) at room temperature, following stoichiometry 1:2...
  55. ncbi Synthesis and properties of cobalt(III) complexes of 4-substituted pyridine-capped dioxocyclams
    Angela L Reiff
    Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, USA
    Inorg Chem 44:9162-74. 2005
    ..6 degrees) is strongly distorted from linear. In contrast, complex has a substantially shortened cyanide N-to-Ru bond (2.017 A) and an almost linear arrangement along the entire bridging axis of the molecule...
  56. ncbi Synthesis, characterization, and cytotoxic activity of copper(II) and platinum(II) complexes of 2-benzoylpyrrole and X-ray structure of bis[2-benzoylpyrrolato(N,O)]copper(II)
    S Rubino
    Dipartimento di Chimica Inorganica, Universita degli Studi di Palermo, Viale delle Scienze, Parco d Orleans, 90128 Palermo, Italy
    J Inorg Biochem 98:2071-9. 2004
    ..While the Pt(II) complexes may have damaged DNA to induce cell death, treatment with the Cu(II) complex did not induce Jurkat cell death...
  57. ncbi Conformational preferences and orbital interactions for methyl haloacetates
    Claudio F Tormena
    Chemistry Department, FFCLRP, Sao Paulo University, Av Bandeirantes 3900, 14040 901 Ribeirao Preto, SP, Brazil
    Spectrochim Acta A Mol Biomol Spectrosc 63:511-7. 2006
    ..This unexpected interaction was possibly due to the high (0.2) electron density on pi(C=O)(*), which results from the interaction between ether oxygen lone pair and pi(C=O)(*)...
  58. ncbi Reexamination of some reactions of 3-(D-galactosylidenehydrazino)-1,2,4-triazino[5,6-b]indole
    M A E Shaban
    Department of Chemistry, Faculty of Science, Alexandria University, Ibrahimia, Alexandria, Egypt
    Pharmazie 58:860-5. 2003
    ..Compound 8 was found to exist in the preponderantly populated sickle (bent) conformation 18 in contrast to compounds 10 and 12 which were found to adopt the extended planar zigzag conformations 19 and 20 respectively...
  59. ncbi Synthesis and spectral characterization of novel compounds derived from 1,10-phenanthroline, lead(II) and tetrabutylammonium tetrafluoroborate
    Maria S Atanassova
    Department of Organic Chemistry, University of Chemical Technology and Metallurgy, 1756, Sofia, Bulgaria
    Spectrochim Acta A Mol Biomol Spectrosc 59:1655-62. 2003
    ..These are the 1:1 adduct (phen)*(Bu4N*BF4) and the complex Pb(phen)(Bu4N*BF4)3(NO3)2. The synthesized substances have been characterized by UV, IR and Raman spectroscopy as well as by 1H- and 19F-NMR spectroscopy...
  60. ncbi Structures of ionic liquids with different anions studied by infrared vibration spectroscopy
    Yoonnam Jeon
    Department of Physics and Interdisciplinary Program of Integrated Biotechnology, Sogang University, Seoul 121 742, Korea
    J Phys Chem B 112:4735-40. 2008
    ..These differences are considered to come from the variation in the position of the anion, where I- is expected to be closer to the C(2) hydrogen of the imidazolium cation and interacting more specifically as compared to BF(4-)...
  61. ncbi New antiviral cassane furanoditerpenes from Caesalpinia minax
    R W Jiang
    Department of Chemistry and Institute of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China
    J Nat Prod 64:1266-72. 2001
    ..As the major components of the plant possess significant potent activity, it may be feasible to develop new antiviral agents from this source...
  62. ncbi Suillusin, a unique benzofuran from the mushroom Suillus granulatus
    B S Yun
    Korea Research Institute of Bioscience and Biotechnology, P.O. Box 115, Yusong, Taejon 305-600, Korea
    J Nat Prod 64:1230-1. 2001
    ..Its structure was assigned on the basis of various spectroscopic analyses as a highly substituted novel 1H-cyclopenta[b]benzofuran (1). Suillusin is suggested to be biogenerated from polyporic acid...
  63. ncbi Five new diprenylated flavonols from the leaves of Broussonetia kazinoki
    P C Zhang
    Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, People's Republic of China
    J Nat Prod 64:1206-9. 2001
    ..Their structures were elucidated by chemical and spectral methods. Cytotoxic activities were evaluated against several different cell lines...
  64. ncbi Xanthones from Garcinia parvifolia
    Y J Xu
    Department of Chemistry, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260
    J Nat Prod 64:1191-5. 2001
    ..The structures were determined by spectroscopic methods...
  65. ncbi Cytotoxicity of Rhamnosylanthraquinones and Rhamnosylanthrones from Rhamnus nepalensis
    L P Mai
    Institut de Chimie des Substances Naturelles, Centre National de la Recherche Scientifique, 91198 Gif-sur-Yvette Cedex, France
    J Nat Prod 64:1162-8. 2001
    ..A structure-cytotoxic activity relationship study was performed on these isolates and some semisynthetic derivatives...
  66. ncbi The alkaloids of Artabotrys uncinatus
    T J Hsieh
    Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
    J Nat Prod 64:1157-61. 2001
    ..Atherospermidine and squamolone exhibited cytotoxicity against hepatocarcinoma cancer cell lines (Hep G(2) and 2,2,15), and the activity of some of the alkaloids in an antithrombin assay is also discussed...
  67. ncbi A new naphthopyrone derivative from Cassia quinquangulata and structural revision of quinquangulin and its glycosides
    X C Li
    National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, The University of Mississippi, University, MS 38677, USA
    J Nat Prod 64:1153-6. 2001
    ..The structures of two quinguangulin glycosides, 3 and 4, were also revised accordingly. Compound 2a exhibited activity against Staphylococcus aureus and methicillin-resistant S. aureus (MIC, 3.125 and 6.25 microg/mL, respectively)...
  68. ncbi Isolation and structure of five new cancer cell growth inhibitory bufadienolides from the Chinese traditional drug Ch'an Su
    T Nogawa
    Faculty of Science, Kanagawa University, 2946 Tsuchiya, Hiratsuka, Kanagawa 259-1293, Japan
    J Nat Prod 64:1148-52. 2001
    ..Bufadienolides 1-5 provided significant inhibitory activity against the KB and HL-60 cancer cell lines. In addition, bufadienolide 1 was found active against the MH-60 cancer cell line...
  69. ncbi Design and structure-activity relationship of thrombin inhibitors with an azaphenylalanine scaffold: potency and selectivity enhancements via P2 optimization
    A Zega
    Faculty of Pharmacy, University of Ljubljana, Askeroe;va 7, 1000, Ljubljana, Slovenia
    Bioorg Med Chem 9:2745-56. 2001
    ..In vitro biological testing of the designed inhibitors shows that elimination of R, S stereoisomerism and restriction of conformational freedom influences the binding of inhibitors in a favorable fashion...
  70. ncbi Two phenanthraquinones from Dendrobium moniliforme
    T H Lin
    Institute of Chinese Pharmaceutical Sciences, China Medical College, 91, Hsueh-Shih Road, Taichung 404, Taiwan, Republic of China
    J Nat Prod 64:1084-6. 2001
    ..This is the first report of compound 1, which possesses a novel 1,4,5,8-diquinone moiety in the phenanthraquinone skeleton. Compound 2 showed potent antiinflammatory effects in vitro...
  71. ncbi New indole alkaloids from the bark of Nauclea orientalis
    Z Zhang
    National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, The University of Mississippi, University, Mississippi 38677, USA
    J Nat Prod 64:1001-5. 2001
    ..The structures of 1-4 were elucidated using 1D and 2D NMR spectral methods, including COSY, DEPT, HMQC, (13)C-(1)H HMBC, and (15)N-(1)H HMBC...
  72. ncbi The use of mixed-mode ion-exchange solid phase extraction to characterize pharmaceutical drug degradation
    Margaret S Landis
    Pfizer Global Research and Development, Pharmaceutical Sciences Division, Eastern Point Road MC 4127, Groton, CT 06340, USA
    J Pharm Biomed Anal 44:1029-39. 2007
    ..Several examples of the use of mixed-mode ion-exchange solid phase extraction to illustrate the utility of this technique are presented...
  73. ncbi Synthesis and structural properties of lanthanide complexes formed with tropolonate ligands
    Jian Zhang
    Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Inorg Chem 46:6473-82. 2007
    ..This analysis will aid us in optimizing ligand design for improved photophysical properties of the complex...
  74. ncbi Metal-catalysed oxidation processes in thiosemicarbazones: new complexes with the ligand N-{2-([4-N-ethylthiosemicarbazone]methyl)phenyl}-p-toluenesulfonamide
    Rosa Pedrido
    Departamento de Quimica Inorganica, Facultade de Quimica, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain
    Chemistry 14:500-12. 2008
    ..CH3CN (8) and [Cu(L3)(H2O)]2.CH3CN.H2O (9). The zinc complex [Zn(L1)]4 (12) displays a particular tetranuclear zeolite-type structure capable of hosting small molecules or ions, presumably through hydrogen bonding...
  75. ncbi Novel GRP78 molecular chaperone expression down-regulators JBIR-04 and -05 isolated from Streptomyces violaceoniger
    Miho Izumikawa
    Japan Biological Information Research Center JBIRC, Japan Biological Informatics Consortium JBIC, Tokyo, Japan
    J Antibiot (Tokyo) 60:640-4. 2007
    ..1 and 2 inhibited the expression of GRP78 induced by 2-deoxyglucose in human fibrosarcoma HT1080 cells, but their activities were highly reduced compared with those of 3 and SW-163A...
  76. ncbi Structure of the dimethyl sulfoxide solvated thallium(III) ion in solution and in the solid state
    G Ma
    Department of Chemistry, Royal Institute of Technology (KTH, SE-100 44 Stockholm, Sweden
    Inorg Chem 40:6432-8. 2001
    ..The (205)Tl, (13)C, and (1)H NMR spectra of the complex in solution show single signals at 1886, 39.5, and 2.3 ppm, respectively...
  77. ncbi Physicochemical characterization of deflazacort: thermal analysis, crystallographic and spectroscopic study
    Silvia L Cuffini
    Agencia Cordoba Ciencia, CEPROCOR, Cordoba, Argentina
    Steroids 72:261-9. 2007
    ..The reactivity of 1 toward light and moisture was examined via DSC and TLC. The data indicated that 1 do not interact with water to give hydrated forms or decomposition products; however, light degrades 1...
  78. ncbi Characterization of enzymatically digested hyaluronic acid using NMR, Raman, IR, and UV-Vis spectroscopies
    Jamal Alyoussef Alkrad
    Institute of Pharmaceutics and Biopharmaceutics, Martin Luther University Halle Wittenberg, Wolfgang Langenbeck Str 4, Halle S 06120, Germany
    J Pharm Biomed Anal 31:545-50. 2003
    ..The relative amount of olefinic proportion in the mixture was obtained from 1H and 13C NMR spectra. The spectroscopy measurement showed an increase in the double bond amount with increasing enzymatic digestion time...
  79. ncbi Vibrational spectra, NMR and theoretical studies of the enantiomers and rotamers of alpha-cypermethrin
    Alicia H Jubert
    CEQUINOR, Centro de Química Inorgánica CONICET UNLP, Departamento de Quimica, Facultad de Ciencias Exactas y Facultad de Ingeniería, Universidad Nacional de La Plata, CC 962, 1900 La Plata, Argentina
    Spectrochim Acta A Mol Biomol Spectrosc 66:1208-21. 2007
    ..The vibrational frequencies and the 1H and 13C NMR chemical shifts were assigned using functional density calculations. The molecular electrostatic potential maps were obtained and analyzed...
  80. ncbi Design and synthesis of 4H-3-(2-phenoxy)phenyl-1,2,4-triazole derivatives as benzodiazepine receptor agonists
    Tahmineh Akbarzadeh
    Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
    Bioorg Med Chem 11:769-73. 2003
    ....
  81. ncbi [Re(III)Cl(3)] core complexes with bifunctional single amino acid chelates
    Sangeeta Ray Banerjee
    Department of Chemistry, Syracuse University, Syracuse, NY 13244, USA
    Inorg Chem 41:5795-802. 2002
    ..980(2) A, c = 12.829(2) A, beta = 91.384(3) degrees, Z = 4, D(calc) = 1.967 g/cm(-)(3); [ReCl(3)(L(4)Et)] (4), monoclinic, C2/c, a = 22.880(1) A, b = 7.4926(4) A, c = 22.560(1) A, beta = 94.186(1) degrees, Z = 8, D(calc) = 2.001 g/cm(-3)...
  82. ncbi Metal complexes with the quinolone antibacterial agent N-propyl-norfloxacin: synthesis, structure and bioactivity
    Eleni K Efthimiadou
    Institute of Physical Chemistry, NCSR Demokritos, GR 15310 Aghia Paraskevi Attikis, Greece
    J Inorg Biochem 101:525-35. 2007
    ..The complexes show equal or decreased biological activity in comparison to the free pr-norfloxacin except UO(2)(pr-norf)(2) which shows better inhibition against S. aureus...
  83. ncbi Experimental and density functional theory and ab initio Hartree-Fock study on the vibrational spectra of 2-(4-fluorobenzylideneamino)-3-mercaptopropanoic acid
    Yong Ye
    Key Laboratory for the Synthesis and Application of Organic Functional Molecules, Ministry of Education, Hubei University, Wuhan 430062, People s Republic of China
    Spectrochim Acta A Mol Biomol Spectrosc 68:85-93. 2007
    ..The vibrational wavenumbers of 4-FC were calculated at same level. The scaled theoretical spectra using B3LYP methods, which are in a good agreement with the experimental ones, are superior to those using HF methods...
  84. ncbi Massarilactones E-G, new metabolites from the endophytic fungus Coniothyrium sp., associated with the plant Artimisia maritima
    Karsten Krohn
    Department of Chemistry, Universität Paderborn, 100 33098 Paderborn, Germany
    Chirality 19:464-70. 2007
    ..The structure of massarilactones E (1) was confirmed by X-ray diffraction analysis, and its absolute configuration determined by the solid-state CD/TDDFT method...
  85. ncbi Terpenoid-related metabolites from a formosan soft coral Nephthea chabrolii
    Jui Hsin Su
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaoshiung, Taiwan, R O C
    Chem Pharm Bull (Tokyo) 55:594-7. 2007
    ..Metabolite 1 has been synthesized previously, but was isolated for the first time from natural sources. Cytotoxic activity of metabolites 1-3 and 5-7 against a limited panel of cancer cell lines is also described...
  86. pmc Self-assembly directed by NH...O hydrogen bonding: new layered molecular arrays derived from 4-tert- butylbenzoic acid and aliphatic diamines
    Robert S Armstrong
    School of Chemistry, University of Sydney, New South Wales 2006, Australia
    Proc Natl Acad Sci U S A 99:4987-92. 2002
    ..In part, the adoption of these unusual layered structures seems to reflect a tendency toward maximization of both the number and strengths of the hydrogen bond interactions in the respective ionic layers...
  87. ncbi Hydroxo-bridged Cubane-type tetrairon(II) clusters supported by sterically-hindered carboxylate ligands
    D Lee
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Inorg Chem 40:6774-81. 2001
    ..Comparisons are made with analogous known [Fe(4)X(4)](n)()(+) (X = O, S) units, and the structural integrity of tetrairon fragments upon a change in oxidation state is discussed together with some possible biological implications...
  88. ncbi Synthesis of allyl-bearing dendrimers with a resorcinarene core and their supramolecular complexes with fullerene C60
    Jorge Domínguez Chavez
    Instituto de Quimica, UNAM, Circuito Exterior Cd Universitaria, Coyoacan, C P 04510, Mexico D F, Mexico
    J Nanosci Nanotechnol 7:1377-85. 2007
    ..Strong pi-pi, CH-pi, and n-pi interactions between the dendrimers and the fullerene C60 were detected in the supramolecular complexes by UV-vis, FTIR, and 13C CP-MAS NMR...
  89. ncbi Halide-templated assembly of polynuclear lanthanide-hydroxo complexes
    Ruiyao Wang
    Department of Chemistry, The University of Arizona, Tucson, Arizona 85721, USA
    Inorg Chem 41:278-86. 2002
    ..Magnetic moments of complexes 1-7 measured at room temperature by using Evans' method are in excellent agreement with those calculated by the Van Vleck equation, assuming magnetically noninteractive lanthanide ions...
  90. ncbi Synthesis, characterization, photophysical properties, and biological labeling studies of a series of luminescent rhenium(I) polypyridine maleimide complexes
    Kenneth Kam Wing Lo
    Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, PR China
    Inorg Chem 41:40-6. 2002
    ..The photoluminescence properties of the labeled biological species have also been investigated...
  91. ncbi A C-H...O=C hydrogen bond? Intramolecular hydrogen bonding in a novel semirubin
    M T Huggins
    Department of Chemistry, University of Nevada, Reno, Nevada 89557 0020, USA
    J Org Chem 66:8402-10. 2001
    ..O=C, weak and detected typically in crystals. Dipyrrinone 1 is found by vapor pressure osmometry to be monomeric in CHCl(3), but its methyl ester (2) tends toward being dimeric, like that of methyl xanthobilirubinate, which is dimeric...
  92. ncbi [Composition of renal stones currently observed in non-industrialized countries]
    Michel Daudon
    Laboratoire Cristal, Service de Biochimie A, Hopital Necker, Paris, France
    Prog Urol 14:1151-61. 2004
    ..To verify whether this difference in the epidemiological profile is still observed today, we analysed renal stones collected in various regions of the globe and compared their composition to that of stones observed in France...
  93. ncbi Infrared spectrophotometry of intraluminal meconium calculi in a neonate with imperforate anus and rectourethral fistula
    Takashi Shimotake
    Division of Surgery, Children s Research Hospital, Kyoto Prefectural University of Medicine, Kyoto 602 0841, Japan
    J Pediatr Surg 41:1173-6. 2006
    ..Intraluminal meconium calculi are a rare cause of neonatal abdominal calcifications in patients with anorectal malformations. To investigate their pathogenesis, we performed infrared spectroscopic analysis of meconium-calcified lesions...
  94. ncbi Comparison of direct (X-ray diffraction and infrared spectrophotometry) and indirect (infrared spectrophotometry) methods for the analysis of alpha-quartz in airborne dusts
    E Kauffer
    Institut National de Recherche et de Sécurité INRS, Avenue de Bourgogne, BP27, 54500 Vandoeuvre les Nancy, France
    Ann Occup Hyg 49:661-71. 2005
    ..alpha-quartz contents measured by different analytical techniques (X-ray diffraction, direct method; and infrared spectrophotometry, direct and indirect methods) were compared...
  95. ncbi Near-infrared spectrophotometry is useful to detect the beneficial pharmacological effects of alprostadil on spinal cord deoxygenation
    Takashi Kunihara
    Department of Cardiovascular Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Ann Thorac Cardiovasc Surg 14:376-81. 2008
    The purpose of this study is to confirm our previous studies that near-infrared spectrophotometry (NIRS) can detect spinal cord ischemia earlier than evoked spinal cord potential (ESP), and to determine whether it can detect the ..
  96. ncbi Effects of midazolam and morphine on cerebral oxygenation and hemodynamics in ventilated premature infants
    A A E M van Alfen-van der Velden
    Subdivision Neonatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Biol Neonate 90:197-202. 2006
    ..Midazolam sedation and morphine analgesia are commonly used in ventilated premature infants...
  97. ncbi Regional differences of cerebral hemoglobin concentration in preterm infants measured by near infrared spectrophotometry
    M Keel
    Clinic for Neonatology, University Hospital Zurich, Switzerland
    Technol Health Care 7:63-73. 1999
    Near infrared spectrophotometry has been used to measure total cerebral hemoglobin concentration (micromol/l) as a major indicator of the oxygen transport capacity in neonates...
  98. ncbi Reduced in vivo skeletal muscle oxygen consumption in patients with chronic heart failure--a study using Near Infrared Spectrophotometry (NIRS)
    Khalid Abozguia
    Department of Cardiovascular Medicine, Medical School, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
    Eur J Heart Fail 10:652-7. 2008
    We used Near Infrared Spectrophotometry (NIRS) during arterial occlusion to measure resting skeletal muscle oxygen consumption in chronic heart failure (CHF) patients and in age-matched healthy volunteers (HVs).
  99. ncbi Significance of elevated cytochrome aa3 in a state of endotoxemia in dogs
    H Ogata
    First Department of Anesthesiology, Dokkyo University School of Medicine, Tochigi, Japan
    Resuscitation 33:63-8. 1996
    It is now possible to detect quantitative changes in cytochrome aa3 by means of near-infrared spectrophotometry. This technique is also suitable for determining oxidised hemoglobin (HbO2), reduced hemoglobin (Hb), cerebral blood volume, ..
  100. ncbi [Recent progress in NIR spectroscopy technology and its application to the field of forestry]
    Yu Mei Gong
    Science and Technology Developing Center of State Forestry Administration, Beijing 100714, China
    Guang Pu Xue Yu Guang Pu Fen Xi 28:1544-8. 2008
    ..The near infrared spectrophotometry (NIRS) can also be used the nondestructive quantitative assessment of the solid wood density, the ..
  101. ncbi Interference of cerebral near-infrared oximetry in patients with icterus
    P L Madsen
    Departments of Anesthesia and Transplantation, Rigshospitalet, Copenhagen, Denmark
    Anesth Analg 90:489-93. 2000
    Near-infrared spectrophotometry assesses cerebral oxygen saturation (ScO(2)) based on the absorption spectra of oxygenated and deoxygenated hemoglobin and the translucency of biological tissue in the near-infrared band...

Research Grants50

  1. Flavohemoglobin-catalyzed nitric oxide dioxygenation
    Paul Gardner; Fiscal Year: 2005
    ..2) Intermediates of the NOD enzyme mechanism are being elucidated using stopped flow, EPR, and infrared spectrophotometry, specific traps, and indicators...
  2. Design and Synthesis of HIV-1 Protease Inhibitors
    AMOS SMITH; Fiscal Year: 2004
    ....
  3. SYNTHESIS OF CHLOROPEPTINS, GP120 CD4 BINDING INHIBITORS
    AMOS SMITH; Fiscal Year: 2001
    ..abstract_text> ..
  4. LIPID CONTROL OF MEMBRANE PROTEIN ORGANIZATION
    Richard Mendelsohn; Fiscal Year: 2007
    ..Finally, the sensitivity of vibrational spectra to molecular structure will be used to map the effects of penetration enhancers on lipid conformation and protein secondary structure. [unreadable] [unreadable]..
  5. SYNTHESIS OF SPONGISTATIN ANTITUMOR AGENTS
    AMOS SMITH; Fiscal Year: 2007
    ..abstract_text> ..
  6. NMR systems : 2 Bruker Avance 500 Consoles
    AMOS SMITH; Fiscal Year: 2006
    ..The areas of public health research include, among others, cancer, infectious diseases, neurodegenerative diseases such as Alzheimer's disease, and heart and cardiovascular disease. [unreadable] [unreadable] [unreadable]..
  7. New Methodology for Indole Alkaloid Syntheses
    Ken S Feldman; Fiscal Year: 2010
    ..The use of a new variant of the Pummerer reaction to control both oxidation level and reaction site within the indole nucleus forms the basis of this chemistry. ..
  8. SkyScan 1172 High-resolution desk-top micro-CT system
    James Williams; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  9. PHYSIOLOGICALLY ACTIVE NATURAL PRODUCTS
    Douglass Taber; Fiscal Year: 2007
    ..In the course of these investigations, new molecular reactivity will be developed that will substantially shorten current routes to polycyclic natural products and drug candidates. ..
  10. The Structure and Assembly of Peptide Aggregates
    SEAN DECATUR; Fiscal Year: 2005
    ..abstract_text> ..
  11. Pseudopteroxazole and Related Antitubercular Agents
    Michael Harmata; Fiscal Year: 2007
    ..More generally, the methodology to be developed should have extremely broad impact, as it can be applied to the generation of stereogenic centers in a large number of compounds of biological and medicinal interest. ..
  12. Interdisciplinary researchers to address biomedical optics challenges, BIOMED 06
    Judith Mourant; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  13. MR imaging of myeloperoxidase activity
    Ralph Weissleder; Fiscal Year: 2007
    ..The ultimate goal of this research is to develop clinically useful imaging tools for the molecular assessment of atherosclerosis in vivo, which are currently limited. [unreadable] [unreadable] [unreadable]..
  14. RAMAN SPECTROSCOPY FOR CANCER DIAGNOSIS AND MONITORING
    Judith Mourant; Fiscal Year: 2005
    ..Consequently, treatments could be customized. ..
  15. MSM: Modeling Spatial Formation of Cellular Components *
    Teresa Head Gordon; Fiscal Year: 2007
    ..The computational results will be tested directly against experiments. [unreadable] [unreadable]..
  16. Alkynyliodonium Salts and Derived Diyls in Synthesis
    Ken Feldman; Fiscal Year: 2009
    ..abstract_text> ..
  17. SPECTROSCOPIC STUDIES OF LIGHT-DRIVEN ELECTRON TRANSFER
    BRIDGETTE ANNE BARRY; Fiscal Year: 2010
    ..This specific aim will serve to elucidate the role of primary, secondary, and tertiary interactions in a structurally defined, tractable model system. ..
  18. MECHANISM OF HARD TISSUE MINERALIZATION
    Adele L Boskey; Fiscal Year: 2010
    ..Aim 3: To determine whether DSPP and BGN interact synergistically during the collagen-based in vitro mineralization process using in vitro and in situ analyses. ..
  19. SYNTHESIS OF ANTICANCER AGENTS
    K C Nicolaou; Fiscal Year: 2010
    ..abstract_text> ..
  20. IN VITRO INITIATION OF BIOLOGICAL CALCIFICATION
    Adele Boskey; Fiscal Year: 2009
    ....
  21. Experimental/Computational Study of Protein Aggregation
    Teresa Head Gordon; Fiscal Year: 2009
    ..A coarse-grained off-lattice simulation and atomistic molecular dynamics will also be applied, characterizing folding trajectories, kinetics, as well as thermodynamics. ..
  22. Micro-computed tomography system (Micro-CT)
    Adele Boskey; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  23. TOTAL SYNTHESIS OF AZADIRACHTIN
    K Nicolaou; Fiscal Year: 2008
    ..The proposed work is expected to impact the general areas of pharmaceutical and agricultural research, and infectious diseases in particular, through discoveries in synthetic organic chemistry and chemical biology. ..
  24. Development of A Multi-Modality System for Onco-Imaging
    Gultekin Gulsen; Fiscal Year: 2007
    ..If successful, the outcome of our effort will offer a sophisticated tool that could provide high sensitivity and high specificity in the detection and characterization of tumors. ..
  25. A Depth-resolved Voltage Sensitive Dye Imaging System
    Elizabeth Hillman; Fiscal Year: 2007
    ..The effects of abnormal pathologies on neurovascular coupling could provide new insights for treatment and prevention. The new system could also find applications in ocular, dermal, endoscopic and tumor imaging. [unreadable] [unreadable]..
  26. ASYMMETRIC SYNTHESIS OF ANTITUMOR AGENTS
    MICHAEL CRIMMINS; Fiscal Year: 2005
    ..Laulimalide stimulates tubulin polymerization more effectively than paclitaxel. Laulimalide is a representative of a new class of microtubule stabilizing agents with promise for therapeutic potential. ..
  27. ASYMMETRIC SYNTHESIS OF NOVEL NATURAL PRODUCTS
    MICHAEL CRIMMINS; Fiscal Year: 2006
    ..Synthesis of the biologically active agents guanacastepene, and SCH 351448 will also be pursued. ..
  28. Proteomic determination of arsenical action
    Partha Basu; Fiscal Year: 2005
    ..These studies will greatly expand the understanding of the biochemical activation of vascular cell signaling that is relevant to arsenic-related vascular diseases. ..
  29. BENZANNULATION APPROACH TO BIARYL ETHERS
    Michael Harmata; Fiscal Year: 2001
    ..abstract_text> ..
  30. TOTAL SYNTHESIS OF NATURAL PRODUCTS
    K Nicolaou; Fiscal Year: 2002
    ..3] sigmatropic rearrangement and a radical based ring closure to form the bicyclic skeleton. ..
  31. Ethanol Discrimination in Transgenic Mice
    KEITH SHELTON; Fiscal Year: 2002
    ..background to the ethanol's discriminative ctimnlnc effects. ..
  32. NON-INVASIVE OPTICAL IMAGING OF THE HUMAN BRAIN
    MARIA FRANCESCHINI; Fiscal Year: 2002
    ..abstract_text> ..
  33. Analysis of Phenolic Phytochemical by ESI-MS
    Jennifer Brodbelt; Fiscal Year: 2003
    ....
  34. Polarization Sensitive OCT for Detection of Melanoma
    Gultekin Gulsen; Fiscal Year: 2003
    ..Thus this research will have the potential to improve patient care and reduce the human and economical cost of melanoma. ..
  35. SPECTROSCOPIC AND RELATED STUDIES ON LENS MEMBRANE LIPID
    Douglas Borchman; Fiscal Year: 2003
    ..An understanding of these alterations will facilitate the development of therapies to prevent or perhaps even reverse these changes. ..
  36. OSTEOPOROSIS, COLLAGEN CROSS-LINKS & BIOMECHANICS
    Adele Boskey; Fiscal Year: 2003
    ..The proposed studies will be based on histology, FTIR Imaging (FTIRI), biomechanical, and biochemical techniques and represent a novel approach to evaluating the organic matrix inosteoporosis. ..
  37. TOTAL SYNTHESIS OF APOPTOLIDIN
    K Nicolaou; Fiscal Year: 2004
    ..The proposed work is expected to have significant impact in the area of cancer chemotherapy and should provide enabling technologies and tools for biology and medicine. ..
  38. LCDIO FOR LYMPH NODE MR IMAGING
    Ralph Weissleder; Fiscal Year: 2001
    ..abstract_text> ..
  39. Chemical and Biological Studies on Biaryl Phenolics
    Ken Feldman; Fiscal Year: 2005
    ..The search for selective 20S proteosome inhibitors among the Ntn-type proteases will be advanced by these investigations. ..
  40. Diffuse optical tomography system for molecular imaging
    Ralph Weissleder; Fiscal Year: 2005
    ....
  41. Experimental Benchmarks for Protein/Water Force Fields
    Teresa Head Gordon; Fiscal Year: 2005
    ..The benchinarking of protein simulations as to the quality of the underlying empirical force fields is naturally addressed in the simulation and experimental research proposed here. ..
  42. Enabling Technologies for Combinatorial Chemistry
    K Nicolaou; Fiscal Year: 2005
    ..abstract_text> ..
  43. HIGH EFFICIENCY LYMPHOCYTE LABELING FOR IN VIVO TRACKING
    Ralph Weissleder; Fiscal Year: 2004
    ..Furthermore, the investigators believe that the proposed research is in the widest interest to the current NIAID program and other research programs in further developing robust tools to track immune cells in vivo. ..
  44. Near-Infrared VCD of Chiral Pharmaceuticals
    Laurence Nafie; Fiscal Year: 2004
    ..This will permit in situ quality of control of chiral and physical properties in final-stage pharmaceutical products. ..
  45. Micromass LCT Mass Spectrometer
    MICHAEL CRIMMINS; Fiscal Year: 2004
    ..The major users group is highly dependent on rapid turn around mass spectral data. Since there is currently no Departmental mass spectrometry facility, the research programs of the major users have been seriously hampered for some time. ..
  46. MR IMAGING OF GENE EXPRESSION
    Ralph Weissleder; Fiscal Year: 2004
    ..The long-term goal of this research is to extend the capabilities of MR and apply it to in vivo imaging of gene expression. ..
  47. PERMEATION OF IRRITANT MIXTURES THRU PROTECTIVE MATERIAL
    SHANE QUE HEE; Fiscal Year: 2002
    ..The relationship of the fundamental independent variables to the kinetic parameters of permeation and to the Corrositex rating as the index of irritation will be determined and compared. ..
  48. COPPER/ALBUMIN REDOX-CYCLING IN PREECLAMPSIA
    Valerian Kagan; Fiscal Year: 2003
    ....
  49. Irradiation Damage and Protection of Pulmonary Endothelium Oxidative Lipidomics
    Valerian E Kagan; Fiscal Year: 2010
    ....
  50. Inductively Coupled Plasma- Mass Spectrometer
    SHANE QUE HEE; Fiscal Year: 2003
    ..A team of researchers has been assembled whose research needs for elemental analyses are in the broad areas of environmental health, nutrition, biomedical and behavioral research. ..