Genomes and Genes
glucose clamp technique
Summary: Maintenance of a constant blood glucose level by perfusion or infusion with glucose or insulin. It is used for the study of metabolic rates (e.g., in glucose, lipid, amino acid metabolism) at constant glucose concentration.
Publications280 found, 100 shown here
- Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivityE Bonora
Division of Endocrinology and Metabolic Diseases, University of Verona Medical School, Italy
Diabetes Care 23:57-63. 2000..To evaluate whether the homeostasis model assessment (HOMA) is a reliable surrogate measure of in vivo insulin sensitivity in humans...
- Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usageRanganath Muniyappa
Diabetes Unit, National Center for Complementary and Alternative Medicine, National Institutes of Health, 9 Memorial Drive, Bldg 9, Rm 1N 105 MSC 0920, Bethesda, MD 20892, USA
Am J Physiol Endocrinol Metab 294:E15-26. 2008..In this Frontiers article, we highlight merits, limitations, and appropriate use of current in vivo measures of insulin sensitivity/resistance...
- Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alphaSamar I Itani
Diabetes Unit, Section of Endocrinology, Department of Medicine, Boston University Medical Center, Boston, MA, USA
Diabetes 51:2005-11. 2002..Whether acute FFA-induced insulin resistance in human skeletal muscle is caused by the activation of these specific PKC isoforms and the IKK-beta/IkappaB/NFkappaB pathway remains to be established...
- Ceramide content is increased in skeletal muscle from obese insulin-resistant humansJohn M Adams
Department of Physiology, The University of Texas Health Science Center at San Antonio, 78229 3900, USA
Diabetes 53:25-31. 2004....
- Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistanceNozomu Kamei
Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
J Biol Chem 281:26602-14. 2006..We concluded that both paracrine and endocrine effects of MCP-1 may contribute to the development of insulin resistance in aP2-MCP-1 mice...
- Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liverMichihiro Matsumoto
Naomi Berrie Diabetes Center, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
Cell Metab 6:208-16. 2007..The data provide a unifying mechanism for regulation of hepatic glucose production by cAMP and insulin...
- Role of hepatic STAT3 in brain-insulin action on hepatic glucose productionHiroshi Inoue
Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
Cell Metab 3:267-75. 2006..These results thus indicate that IL-6-STAT3 signaling in the liver contributes to insulin action in the brain, leading to the suppression of hepatic glucose production...
- Considerations in the design of hyperinsulinemic-euglycemic clamps in the conscious mouseJulio E Ayala
Vanderbilt NIDDK National Institutes of Diabetes and Digestive and Kidney Diseases Mouse Metabolic Phenotyping Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Diabetes 55:390-7. 2006..kg(-1) . min(-1)), but endoR(a) was fully suppressed with doses higher than 0.8 mU . kg(-1) . min(-1). Thus, common variations in experimental factors yield different results and should be considered in designing and interpreting clamps...
- Prevention of obesity and insulin resistance in mice lacking plasminogen activator inhibitor 1Li Jun Ma
Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Diabetes 53:336-46. 2004..Inhibition of PAI-1 might provide a novel anti-obesity and anti-insulin resistance treatment...
- Hypothalamic leptin signaling regulates hepatic insulin sensitivity via a neurocircuit involving the vagus nerveJonathan German
Department of Medicine, University of Washington at South Lake Union, 815 Mercer Street, Box 358055, Seattle, Washington 98195
Endocrinology 150:4502-11. 2009..We conclude that hypothalamic leptin action increases peripheral insulin sensitivity primarily via effects on the liver and that the mechanism underlying this effect is dependent on the hepatic branch of the vagus nerve...
- Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 geneKonstantinos Kantartzis
Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry, University of Tubingen, Tubingen, Germany
Diabetes 58:2616-23. 2009..We investigated whether the SNP determines liver fat independently of visceral adiposity and whether it may even play a role in protecting from insulin resistance...
- Restoration of muscle mitochondrial function and metabolic flexibility in type 2 diabetes by exercise training is paralleled by increased myocellular fat storage and improved insulin sensitivityRuth C R Meex
Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
Diabetes 59:572-9. 2010..We examined whether exercise training could restore mitochondrial function and insulin sensitivity in patients with type 2 diabetes...
- Prolonged fasting identifies skeletal muscle mitochondrial dysfunction as consequence rather than cause of human insulin resistanceJoris Hoeks
Department of Human Biology, School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
Diabetes 59:2117-25. 2010..It is therefore anticipated that skeletal muscle mitochondrial function is maintained to accommodate increased fat oxidation unless factors secondary to insulin resistance exert negative effects on mitochondrial function...
- Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight lossMargaret F Gregor
Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts, USA
Diabetes 58:693-700. 2009..Therefore, we tested whether these stress pathways were also present in obese human subjects and/or regulated by weight loss...
- Increased liver fat, impaired insulin clearance, and hepatic and adipose tissue insulin resistance in type 2 diabetesAnna Kotronen
Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki, Finland
Gastroenterology 135:122-30. 2008..We also examined whether insulin suppression of serum free fatty acid (FFA) correlates with liver fat...
- Body fat distribution and insulin resistance in healthy Asian Indians and CaucasiansA Raji
Endocrine Hypertension Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Clin Endocrinol Metab 86:5366-71. 2001..Alterations in body fat distribution--particularly increased visceral fat--may contribute to these abnormalities...
- Chronic treatment with sildenafil improves energy balance and insulin action in high fat-fed conscious miceJulio E Ayala
Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, 2200 Pierce Ave, 702 Light Hall, Nashville, TN 37232, USA
Diabetes 56:1025-33. 2007..These results show that phosphodiesterase-5 is a potential target for therapies aimed at preventing diet-induced energy imbalance and insulin resistance...
- Relationship between hepatic/visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabetic subjectsAmalia Gastaldelli
Division of Diabetes, Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
Gastroenterology 133:496-506. 2007..We examined the relationship between visceral/hepatic fat accumulation and hepatic IR/accelerated gluconeogenesis (GNG)...
- The assessment of insulin resistance in manT M Wallace
The Oxford Centre for Diabetes, Endocrinology and Metabolism, The Radcliffe Infirmary, UK
Diabet Med 19:527-34. 2002..The ability to measure insulin resistance is important in order to understand the aetiopathology of Type 2 diabetes, to examine the epidemiology and to assess the effects of intervention...
- n-3 Fatty acids preserve insulin sensitivity in vivo in a peroxisome proliferator-activated receptor-alpha-dependent mannerSusanne Neschen
Yale University School of Medicine, Howard Hughes Medical Institute, Departments of Internal Medicine, The Anlyan Center, P O Box 9812, New Haven, CT 06536 8012, USA
Diabetes 56:1034-41. 2007..0001 vs. genotype control). These data support the hypothesis that n-3 fatty acids protect from high-fat diet-induced hepatic insulin resistance in a PPAR-alpha-and diacylglycerol-dependent manner...
- Meal and oral glucose tests for assessment of beta -cell function: modeling analysis in normal subjectsAndrea Mari
Consiglio Nazionale delle Ricerche Institute of Systems Science and Biomedical Engineering, 35127 Padua, Italy
Am J Physiol Endocrinol Metab 283:E1159-66. 2002..With cautious interpretation, a 2-h MT or a standard OGTT can be used as surrogates of 24-h tests in assessing spontaneous beta-cell function...
- Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesityElisa Fabbrini
Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 106:15430-5. 2009..Furthermore, alterations in tissue fatty acid transport could be involved in the pathogenesis of ectopic triglyceride accumulation by redirecting plasma fatty acid uptake from adipose tissue toward other tissues...
- Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistanceClinton R Bruce
Cellular and Molecular Metabolism Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
Diabetes 58:550-8. 2009....
- Liver, muscle, and adipose tissue insulin action is directly related to intrahepatic triglyceride content in obese subjectsKevin M Korenblat
Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri, USA
Gastroenterology 134:1369-75. 2008....
- Intracerebroventricular administration of neuropeptide Y induces hepatic insulin resistance via sympathetic innervationAnita M van den Hoek
TNO Quality of Life, Gaubius Laboratory, Leiden, The Netherlands
Diabetes 57:2304-10. 2008..Therefore, the aim of this study was to establish whether intracerebroventricular NPY administration modulates the suppressive action of insulin on EGP via hepatic sympathetic or parasympathetic innervation...
- Metformin prevents the development of acute lipid-induced insulin resistance in the rat through altered hepatic signaling mechanismsMark E Cleasby
Diabetes and Obesity Program, Garvan Institute of Medical Research, Sydney, Australia
Diabetes 53:3258-66. 2004..In summary, metformin opposes the development of acute lipid-induced insulin resistance in the liver through alterations in multiple signaling pathways...
- Insulin resistance and secretion in vivo: effects of different antipsychotics in an animal modelAraba F Chintoh
Institute of Medical Science, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada
Schizophr Res 108:127-33. 2009..Our data also support the preclinical use of these clamp procedures in screening putative antipsychotics...
- Hepatic insulin resistance precedes the development of diabetes in a model of intrauterine growth retardationPatricia Vuguin
Children s Hospital at Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York, USA
Diabetes 53:2617-22. 2004....
- Obesity blunts insulin-mediated microvascular recruitment in human forearm muscleLucy H Clerk
Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Virginia Health System, P O Box 801410, 450 Ray C Hunt Drive, Charlottesville, VA 22908, USA
Diabetes 55:1436-42. 2006..482, P = 0.027) in response to insulin. In conclusion, obesity eliminated the insulin-stimulated muscle microvascular recruitment and increased brachial artery blood flow seen in lean individuals...
- Metabolic adaptations to dexamethasone-induced insulin resistance in healthy volunteersNathalie Nicod
Institute of Physiology, University of Lausanne, Lausanne, Switzerland
Obes Res 11:625-31. 2003..The objective of this study was to evaluate a procedure aimed at assessing the compensatory mechanisms to insulin resistance...
- Muscle-derived angiopoietin-like protein 4 is induced by fatty acids via peroxisome proliferator-activated receptor (PPAR)-delta and is of metabolic relevance in humansHarald Staiger
Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany
Diabetes 58:579-89. 2009..Long-chain fatty acids (LCFAs) contribute to metabolic homeostasis in part via gene regulation. This study's objective was to identify novel LCFA target genes in human skeletal muscle cells (myotubes)...
- Metabolic flexibility in response to glucose is not impaired in people with type 2 diabetes after controlling for glucose disposal rateJose E Galgani
Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
Diabetes 57:841-5. 2008....
- Insulin sensitivity differs among ethnic groups with a compensatory response in beta-cell functionK C Chiu
Department of Medicine, University of California, Los Angeles, School of Medicine, USA
Diabetes Care 23:1353-8. 2000..A drastic difference is evident in the prevalence of type 2 diabetes among ethnic groups. We examined the role of beta-cell function and insulin sensitivity in this disparity among 4 ethnic groups...
- 13C/31P NMR studies on the mechanism of insulin resistance in obesityK F Petersen
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8020, USA
Diabetes 47:381-6. 1998..We conclude that insulin resistance in obesity can be mostly attributed to impairment of insulin-stimulated muscle glycogen synthesis due to a defect in glucose transport and/or phosphorylation activity...
- Minimal model estimation of glucose absorption and insulin sensitivity from oral test: validation with a tracer methodChiara Dalla Man
Department of Information Engineering, University of Padova, Via Gradenigo 6 b, I 35131, Italy
Am J Physiol Endocrinol Metab 287:E637-43. 2004..86 (P < 0.0001). We conclude that OMM candidates as a reliable tool to measure both the rate of glucose absorption and insulin sensitivity from oral glucose tests without employing tracers...
- Effects of adding exercise to a 16-week very low-calorie diet in obese, insulin-dependent type 2 diabetes mellitus patientsMarieke Snel
Department of Endocrinology and Metabolism, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
J Clin Endocrinol Metab 97:2512-20. 2012..Reduction of 50% excess body weight, using a very low-calorie diet (VLCD; 450 kcal/d) improves insulin sensitivity in obese type 2 diabetes mellitus patients...
- Combining short-term metformin treatment and one bout of exercise does not increase insulin action in insulin-resistant individualsCarrie G Sharoff
Department of Kinesiology, University of Massachusetts Amherst, USA
Am J Physiol Endocrinol Metab 298:E815-23. 2010..These findings suggest that the combination of short-term metformin treatment and an acute bout of exercise does not enhance insulin sensitivity, and the addition of metformin may attenuate the well-documented effects of exercise alone...
- Mechanisms of recovery from type 2 diabetes after malabsorptive bariatric surgeryCaterina Guidone
Dipartimento di Medicina Interna, Catholic University, Largo A Gemelli, 8, 00168 Rome, Italy
Diabetes 55:2025-31. 2006..This operation may affect the enteroinsular axis function by diverting nutrients away from the proximal gastrointestinal tract and by delivering incompletely digested nutrients to the ileum...
- Mice with gene disruption of both endothelial and neuronal nitric oxide synthase exhibit insulin resistanceR R Shankar
Department of Pediatrics, Indiana University School of Medicine, Indianapolis, USA
Diabetes 49:684-7. 2000..These data indicate that NO plays a role in modulating insulin sensitivity and carbohydrate metabolism and that the eNOS isoform may play a dominant role relative to nNOS...
- Characterization of the metabolic and physiologic response to chromium supplementation in subjects with type 2 diabetes mellitusWilliam T Cefalu
Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
Metabolism 59:755-62. 2010..Thus, modulation of lipid metabolism by Cr in peripheral tissues may represent a novel mechanism of action...
- Estrogen sulfotransferase regulates body fat and glucose homeostasis in female miceVictor K Khor
Department of Medicine and Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Am J Physiol Endocrinol Metab 299:E657-64. 2010..In contrast, hepatic insulin sensitivity was improved but muscle insulin sensitivity did not change in EST transgenic mice. These results reveal novel effects of EST on adipose tissue and glucose homeostasis in female mice...
- Relationship between testosterone levels, insulin sensitivity, and mitochondrial function in menNelly Pitteloud
Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
Diabetes Care 28:1636-42. 2005..The goal of this study was to examine the relationship between serum testosterone levels and insulin sensitivity and mitochondrial function in men...
- Insulin resistance in patients with chronic kidney diseaseShuzo Kobayashi
Department of Nephrology and Kidney and Dialysis Center, Shonan Kamakura General Hospital, Kamakura, Japan
Am J Kidney Dis 45:275-80. 2005..However, few data are available concerning what factors of metabolic abnormalities, such as apolipoprotein (Apo) profile or acidosis, might be associated with insulin resistance in patients with CKD...
- Physical inactivity and obesity underlie the insulin resistance of agingFrancesca Amati
Department of Health and Physical Activity, School of Education, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Diabetes Care 32:1547-9. 2009..CONCLUSIONS Insulin resistance may not be characteristic of aging but rather associated with obesity and physical inactivity...
- Physical training may enhance beta-cell function in type 2 diabetesFlemming Dela
Copenhagen Muscle Research Centre, The Panum Institute, University of Copenhagen, 2200 Copenhagen N, Denmark
Am J Physiol Endocrinol Metab 287:E1024-31. 2004..The improved beta-cell function does not require changes in insulin sensitivity and Hb A(1c) concentration...
- Effects of insulin on the metabolic control of hepatic gluconeogenesis in vivoDale S Edgerton
Vanderbilt University Medical Center, Nashville, Tennessee, USA
Diabetes 58:2766-75. 2009....
- Relation of direct and surrogate measures of insulin resistance to cardiovascular risk factors in nondiabetic finnish offspring of type 2 diabetic individualsCarlos Lorenzo
Department of Medicine, University of Texas Health Science Center, Room 5 594U, San Antonio, Texas 78229, USA
J Clin Endocrinol Metab 95:5082-90. 2010..Methods to directly measure insulin resistance are invasive, complex, and costly. Surrogate indexes derived from the oral glucose tolerance test (OGTT) have been developed, but few studies have systematically analyzed these indexes...
- Importance of quantifying insulin secretion in relation to insulin sensitivity to accurately assess beta cell function in clinical studiesBo Ahren
Department of Medicine, Lund University, Lund, Sweden
Eur J Endocrinol 150:97-104. 2004..Acknowledging this inverse relationship between insulin secretion and insulin sensitivity therefore requires estimation of both variables for correct assessment in any individual...
- Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B affect different aspects of pancreatic beta-cell functionAnnemarie M Simonis-Bik
Diabetes Center, VU University Medical Center, Amsterdam, The Netherlands
Diabetes 59:293-301. 2010..In this study we used hyperglycemic clamps with three different stimuli to test associations between these novel loci and various measures of beta-cell function...
- Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetesKitt Falk Petersen
Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510, USA
N Engl J Med 350:664-71. 2004..Insulin resistance appears to be the best predictor of the development of diabetes in the children of patients with type 2 diabetes, but the mechanism responsible is unknown...
- Insulin resistance, defective insulin-mediated fatty acid suppression, and coronary artery calcification in subjects with and without type 1 diabetes: The CACTI studyIrene E Schauer
Department of Medicine, University of Colorado Denver, Aurora, USA
Diabetes 60:306-14. 2011..To assess insulin action on peripheral glucose utilization and nonesterified fatty acid (NEFA) suppression as a predictor of coronary artery calcification (CAC) in patients with type 1 diabetes and nondiabetic controls...
- Metabolic effects of visceral fat accumulation in type 2 diabetesAmalia Gastaldelli
Metabolism Unit, Department of Internal Medicine, University of Pisa, Via Savi, I 56100 Pisa, Italy
J Clin Endocrinol Metab 87:5098-103. 2002..05). We conclude that in patients with established type 2 diabetes, VF accumulation has a significant negative impact on glycemic control through a decrease in peripheral insulin sensitivity and an enhancement of gluconeogenesis...
- Efficacy and safety of leptin-replacement therapy and possible mechanisms of leptin actions in patients with generalized lipodystrophyKen Ebihara
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kyoto 606 8507, Japan
J Clin Endocrinol Metab 92:532-41. 2007....
- Prenatal and postnatal pathways to obesity: different underlying mechanisms, different metabolic outcomesNichola M Thompson
Liggins Institute, The University of Auckland, Private Bag 92019, Auckland, New Zealand
Endocrinology 148:2345-54. 2007..The origin of insulin hypersecretion in IUGR offspring may be independent of the mechanistic events that trigger the insulin resistance commonly observed in DIO...
- Effects of hyperglycemia and hyperinsulinemia on circulating tissue factor procoagulant activity and platelet CD40 ligandVijender R Vaidyula
Temple University Hospital, 3401 North Broad Street, Philadelphia, PA 19140, USA
Diabetes 55:202-8. 2006....
- Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)H Cho
Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
Science 292:1728-31. 2001..These data establish Akt2 as an essential gene in the maintenance of normal glucose homeostasis...
- Validation of insulin sensitivity indices from oral glucose tolerance test parameters in obese children and adolescentsCatherine W Yeckel
Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
J Clin Endocrinol Metab 89:1096-101. 2004..74 and -0.71; P < 0.0001), a tissue marker for insulin resistance. Insulin sensitivity can be estimated using plasma glucose and insulin responses derived from the OGTT in obese youth with normal and impaired glucose tolerance...
- Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parentsKatsutaro Morino
Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06536 8012, USA
J Clin Invest 115:3587-93. 2005....
- Insulin resistance after a 72-h fast is associated with impaired AS160 phosphorylation and accumulation of lipid and glycogen in human skeletal muscleM H Vendelbo
Department of Clinical Pharmacology, Aarhus University Hospital NBG, Aarhus C, Denmark
Am J Physiol Endocrinol Metab 302:E190-200. 2012..This impairment of AS160 phosphorylation, in combination with glycogen accumulation and increased intramuscular lipid content, may provide the underlying mechanisms for resistance to insulin in skeletal muscle after a prolonged fast...
- Insulin secretion and action in subjects with impaired fasting glucose and impaired glucose tolerance: results from the Veterans Administration Genetic Epidemiology StudyMuhammad A Abdul-Ghani
Diabetes Division, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
Diabetes 55:1430-5. 2006..Differences in insulin sensitivity and insulin secretion may predict different rates of progression to type 2 diabetes and varying susceptibility to cardiovascular disease...
- Alpha cell function in health and disease: influence of glucagon-like peptide-1B E Dunning
PharmaWrite, LLC, Princeton, NJ, USA
Diabetologia 48:1700-13. 2005..Therapeutic approaches based around GLP-1 have the potential to improve both alpha cell and beta cell function, and could be of benefit in patients with a broad range of metabolic disorders...
- Effects of olanzapine and haloperidol on the metabolic status of healthy menSolrun Vidarsdottir
Department of Endocrinology and Metabolism, Leiden University Medical Center, Leiden, The Netherlands
J Clin Endocrinol Metab 95:118-25. 2010..The aim of this study was to determine the effect of short-term olanzapine (atypical antipsychotic drug) and haloperidol (conventional antipsychotic drug) treatment on glucose and lipid metabolism...
- Declining beta-cell function relative to insulin sensitivity with increasing fasting glucose levels in the nondiabetic range in childrenHala Tfayli
Division of Weight Management and Wellness, Children s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Diabetes Care 33:2024-30. 2010..This investigation tested the hypothesis that beta-cell function relative to insulin sensitivity decreases with increasing FPG in youth...
- Plasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphorylation, and low plasma concentration precedes a decrease in whole-body insulin sensitivity in humansNorbert Stefan
Clinical Diabetes and Nutrition Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
Diabetes 51:1884-8. 2002..Prospectively, low plasma adiponectin concentration at baseline precedes a decrease in insulin sensitivity. Our data indicate that adiponectin plays an important role in regulation of insulin sensitivity in humans...
- Relationship between insulin sensitivity and sphingomyelin signaling pathway in human skeletal muscleMarek Straczkowski
Department of Endocrinology, Diabetology and Internal Medicine, Medical University Bialystok, M C Sklodowskiej 24a, 15 276 Bialystok, Poland
Diabetes 53:1215-21. 2004..68, P = 0.03) and linoleic (r = -0.66, P = 0.038) acid. Our data indicate that the sphingomyelin signaling pathway in muscle might be an important factor determining the development of insulin resistance in humans...
- Hypoglycemia-associated autonomic failure in advanced type 2 diabetesScott A Segel
Division of Endocrinology, Diabetes and Metabolism, and the General Clinical Research Center and the Diabetes Research and Training Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
Diabetes 51:724-33. 2002....
- Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parentsG Perseghin
Division of Internal Medicine, Istituto Scientifico H San Raffaele, Milan, Italy
Diabetes 48:1600-6. 1999....
- A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetesSangeeta Kashyap
Diabetes Division, Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284 3900, USA
Diabetes 52:2461-74. 2003....
- Brain-derived neurotrophic factor (BDNF) and type 2 diabetesK S Krabbe
The Centre of Inflammation and Metabolism, Department of Infectious Diseases, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
Diabetologia 50:431-8. 2007..These disorders are associated with type 2 diabetes, and animal models suggest that BDNF plays a role in insulin resistance. We therefore explored whether BDNF plays a role in human glucose metabolism...
- Bioactives in blueberries improve insulin sensitivity in obese, insulin-resistant men and womenApril J Stull
Center for the Study of Botanicals and Metabolic Syndrome, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
J Nutr 140:1764-8. 2010..In conclusion, daily dietary supplementation with bioactives from whole blueberries improved insulin sensitivity in obese, nondiabetic, and insulin-resistant participants...
- Exercise training increases insulin-stimulated glucose disposal and GLUT4 (SLC2A4) protein content in patients with type 2 diabetesD J O'Gorman
Metabolic Research Unit, St James s Hospital, Trinity College, Dublin, Ireland
Diabetologia 49:2983-92. 2006..The aim of this study was to assess the impact of acute and short-term exercise training on whole-body insulin-mediated glucose disposal and signal transduction along the canonical insulin signalling cascade...
- Proteomics analysis of human skeletal muscle reveals novel abnormalities in obesity and type 2 diabetesHyonson Hwang
Center for Metabolic Biology, Arizona State University, Tempe, Arizona, USA
Diabetes 59:33-42. 2010..However, changes in mRNA levels may not predict changes in protein abundance. An approach to identify global protein abundance changes involving the use of proteomics was used here...
- Comparison of insulin sensitivity, clearance, and secretion estimates using euglycemic and hyperglycemic clamps in childrenGabriel I Uwaifo
Unit on Growth and Obesity, Developmental Endocrinology Branch, National Institutes of Child Health and Human Development, National Institutes of Health, 10 Center Drive, Building 10 Room 10N262, Bethesda, MD 20892 1862, USA
J Clin Endocrinol Metab 87:2899-905. 2002..It cannot be assumed that the hyperglycemic clamp obviates the need for euglycemic clamp studies to accurately estimate insulin sensitivity in children...
- Oral disposition index in obese youth from normal to prediabetes to diabetes: relationship to clamp disposition indexLindsey George Sjaarda
Division of Weight Management and Wellness, Children s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA 15224, USA
J Pediatr 161:51-7. 2012....
- Insulin signaling in human skeletal muscle: time course and effect of exerciseJ F Wojtaszewski
Copenhagen Muscle Research Centre, August Krogh Institute, University of Copenhagen, Denmark
Diabetes 46:1775-81. 1997..Thus, the activity of IRS-1-associated PI 3-kinase and glucose uptake may not always be tightly coupled during insulin stimulation in human muscle...
- Gender differences in renal responses to hyperglycemia and angiotensin-converting enzyme inhibition in diabetesDavid Z I Cherney
Division of Nephrology, Toronto General Hospital, Toronto, Ontario, Canada
Kidney Int 68:1722-8. 2005....
- The DGAT2 gene is a candidate for the dissociation between fatty liver and insulin resistance in humansKonstantinos Kantartzis
Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry, University of Tubingen, 72076 Tubingen, Germany
Clin Sci (Lond) 116:531-7. 2009..This finding may be important in the prevention and treatment of insulin resistance and Type 2 diabetes in subjects with fatty liver...
- Effects of olanzapine and ziprasidone on glucose tolerance in healthy volunteersJulia Sacher
Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
Neuropsychopharmacology 33:1633-41. 2008..Our finding is suggestive that not all atypical antipsychotics cause acute direct effects on glucose disposal and that accurate determination of side effect profile should be performed when choosing an atypical antipsychotic...
- Comparison of simple indices of insulin sensitivity using the euglycemic hyperinsulinemic clamp techniqueMarek Straczkowski
Department of Endocrinology, Diabetology and Internal Medicine, Medical University, Białystok, Poland
Med Sci Monit 10:CR480-4. 2004..Therefore, indirect indices of insulin sensitivity are proposed. The aim of the present study was to compare these simple indices with data from clamp studies...
- Liver-specific suppressor of cytokine signaling-3 deletion in mice enhances hepatic insulin sensitivity and lipogenesis resulting in fatty liver and obesityNirupa Sachithanandan
St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia
Hepatology 52:1632-42. 2010..SOCS3 LKO mice fed an HFD also had elevated hypothalamic SOCS3 and fatty acid synthase expression and developed greater obesity due to increased food intake and reduced energy expenditure...
- Physiological and molecular determinants of insulin action in the baboonAlberto O Chavez
Diabetes Division, Department of Medicine, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
Diabetes 57:899-908. 2008..To quantitate insulin sensitivity in lean and obese nondiabetic baboons and examine the underlying cellular/molecular mechanisms responsible for impaired insulin action to characterize a baboon model of insulin resistance...
- Surgical removal of omental fat does not improve insulin sensitivity and cardiovascular risk factors in obese adultsElisa Fabbrini
Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, Missouri, USA
Gastroenterology 139:448-55. 2010..Therefore, a reduction in VAT is considered an important target of obesity therapy. We evaluated whether reducing VAT mass by surgical removal of the omentum improves insulin sensitivity and metabolic function in obese patients...
- Brain glucose concentrations in poorly controlled diabetes mellitus as measured by high-field magnetic resonance spectroscopyElizabeth R Seaquist
Department of Medicine, University of Minnesota Medical School, MN 55455, USA
Metabolism 54:1008-13. 2005..1 micromol/g wet wt; P = .1). Our sample size gave 80% power to detect a difference as small as 1.1 micromol/g wet wt. We conclude that chronic hyperglycemia in diabetes does not alter brain glucose concentrations in human subjects...
- Effects of feed restriction and cold exposure on glucose metabolism in response to feeding and insulin in sheepH Sano
Department of Bioscience and Technology, Faculty of Agriculture, Iwate University, Morioka, Japan
J Anim Sci 77:2564-73. 1999..Moreover, the action of insulin on glucose metabolism is enhanced during cold exposure, and the effect of feed restriction is somewhat enhanced...
- Glucose prevents the fall in ventromedial hypothalamic GABA that is required for full activation of glucose counterregulatory responses during hypoglycemiaWanling Zhu
Section of Endocrinology, Department of Internal Medicine, Yale University School of Medicine, 300 Cedar St, New Haven, CT, USA
Am J Physiol Endocrinol Metab 298:E971-7. 2010....
- Carotid artery intima-media thickness is associated with insulin-mediated glucose disposal in nondiabetic normotensive offspring of type 2 diabetic patientsMarina Cardellini
Dipartimento di Medicina Sperimentale e Clinica, Policlinico Universitario Mater Domini, Via Europa, Campus Germaneto, 88100 Catanzaro, Italy
Am J Physiol Endocrinol Metab 292:E347-52. 2007..7% of its variation. These findings support the concept that insulin sensitivity, rather than plasma insulin levels, is associated with early atherosclerosis in nondiabetic normotensive offspring of type 2 diabetic patients...
- Skeletal muscle mitochondria in insulin resistance: differences in intermyofibrillar versus subsarcolemmal subpopulations and relationship to metabolic flexibilityPeter Chomentowski
Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
J Clin Endocrinol Metab 96:494-503. 2011..Insulin resistance is accompanied by lower lipid oxidation during fasting and metabolic inflexibility. Whether these abnormalities correlate with mitochondrial content in skeletal muscle is unknown...
- Combined risk allele score of eight type 2 diabetes genes is associated with reduced first-phase glucose-stimulated insulin secretion during hyperglycemic clampsLeen M 't Hart
Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
Diabetes 59:287-92. 2010..In this study, we have investigated the combined effects of eight known beta-cell loci on insulin secretion stimulated by three different secretagogues during hyperglycemic clamps...
- Low plasma insulin-like growth factor-1 levels are associated with reduced insulin sensitivity and increased insulin secretion in nondiabetic subjectsE Succurro
Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, Viale Europa, 88100 Catanzaro, Italy
Nutr Metab Cardiovasc Dis 19:713-9. 2009..In this cross-sectional study, we analyzed the relationship between IGF-1 levels, insulin sensitivity and secretion in 110 nondiabetic subjects with a wide range of BMI to verify this hypothesis...
- A Thr94Ala mutation in human liver fatty acid-binding protein contributes to reduced hepatic glycogenolysis and blunted elevation of plasma glucose levels in lipid-exposed subjectsMartin O Weickert
Dept of Clinical Nutrition, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
Am J Physiol Endocrinol Metab 293:E1078-84. 2007....
- Relationship between the hyperinsulinemic-euglycaemic clamp and a new simple index assessing insulin sensitivity in overweight and obese postmenopausal womenJ P Bastard
Service de Biochimie et Hormonologie, Hopital Tenon, APHP, 75020 Paris, France
Diabetes Metab 33:261-8. 2007..The purpose of this study was to compare assessment of insulin sensitivity from hyperinsulinemic euglycaemic (HIEG) clamp with indexes derived from fasting and oral glucose tolerance test (OGTT)...
- Gender differences in vascular function and insulin sensitivity in young adultsDonald R Dengel
School of Kinesiology, University of Minnesota, Minneapolis, MN 55455, USA
Clin Sci (Lond) 120:153-60. 2011..However, the lower EID observed in males could not be explained by artery diameter. Future studies need to continue to examine influence of gender on EID and other measures of vascular function...
- Decreased expression of heat shock protein 72 in skeletal muscle of patients with type 2 diabetes correlates with insulin resistanceIstvan Kurucz
Department of Cellular Biology, BIOREX Research and Development, Veszprem, Hungary
Diabetes 51:1102-9. 2002....
- Hypothalamic nutrient sensing activates a forebrain-hindbrain neuronal circuit to regulate glucose production in vivoCarol K L Lam
Toronto General Research Institute, University Health Network, Ontario, Canada
Diabetes 60:107-13. 2011..These studies raise the possibility that hypothalamic nutrient sensing activates a forebrain-hindbrain NMDA-dependent circuit to regulate glucose production...
- Measuring the acute effect of insulin infusion on ATP turnover rate in human skeletal muscle using phosphorus-31 magnetic resonance saturation transfer spectroscopyEe Lin Lim
Institute of Cellular Medicine, Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, UK
NMR Biomed 23:952-7. 2010..03 vs baseline). The in vivo time course of insulin stimulation of skeletal muscle ATP turnover rate is not consistent with a rate limiting effect upon the initiation of insulin-stimulated glycogen synthesis...
- The biochemical assessment of insulin resistanceAnwar Borai
Centre for Clinical Science and Measurement, School of Biomedical and Molecular Sciences, University of Surrey, Guildford, Surrey, UK
Ann Clin Biochem 44:324-42. 2007..Insulin resistance is increasingly being assessed in clinical situations, where relatively simple markers are required. Insulin-like growth factor binding protein-1 is an emerging marker which may be useful in this context...
- Elevated free fatty acids attenuate the insulin-induced suppression of PDK4 gene expression in human skeletal muscle: potential role of intramuscular long-chain acyl-coenzyme AKostas Tsintzas
Centre for Integrated Systems Biology and Medicine, Institute of Clinical Research, School of Biomedical Sciences, University of Nottingham, Nottingham NG7 2UH, United Kingdom
J Clin Endocrinol Metab 92:3967-72. 2007..We investigated the effect of elevated plasma free fatty acid and insulin concentrations on PDK4 mRNA transcript and protein content and long-chain acyl-coenzyme A accumulation in human skeletal muscle...
- Acute elevation of plasma lipids does not affect ATP synthesis in human skeletal muscleA Brehm
First Medical Department, Hanusch Hospital, Vienna, Austria
Am J Physiol Endocrinol Metab 299:E33-8. 2010..This suggests that lipid-induced insulin resistance results primarily from mechanisms decreasing glucose uptake rather than from direct interference of fatty acid metabolites with mitochondrial function...
- Central nervous system delivery of the antipsychotic olanzapine induces hepatic insulin resistancePaulo J F Martins
Obesity Research Center, University of Cincinnati, Cincinnati, Ohio, USA
Diabetes 59:2418-25. 2010..Recent evidence shows that OLZ alters insulin sensitivity independent of changes in body weight and composition. The present study addresses whether OLZ-induced insulin resistance is driven by its central actions...
- Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalkChristoph Handschin
Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA
J Clin Invest 117:3463-74. 2007..These data clearly illustrate a causal role for muscle PGC-1alpha in maintenance of glucose homeostasis and highlight an unexpected cytokine-mediated crosstalk between skeletal muscle and pancreatic islets...
- Prevention of fat-induced insulin resistance by salicylateJ K Kim
Howard Hughes Medical Institute, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06536-8012, USA
J Clin Invest 108:437-46. 2001....
- Ang II and Overnutrition and Insulin resistance in Cardiovascular TissueJAMES RUSSELL SOWERS; Fiscal Year: 2013..A better understanding of factors involved in insulin resistance should help in the development of therapeutic targets to help prevent diabetes and cardiovascular disease. ..
- Biology of IGFs in BoneThomas L Clemens; Fiscal Year: 2013..An understanding of this pathway should ultimately enable better management of diabetic veterans and conceivably lead to the design a single therapy, which can simultaneously target both osteoporosis and type 2 diabetes. ..
- Interactions of the RAAS and a Western Diet on Insulin Metabolic ActionsJAMES RUSSELL SOWERS; Fiscal Year: 2013..tyrosine (p) and the resultant downstream IRS-1/PI3-K/Akt signaling. ..
- Endoplasmic Reticulum Chaperone as a Regulator of Obesity and DiabetesAmy S Lee; Fiscal Year: 2010..If validated, our findings may lead to new targets for therapy against obesity and type 2 diabetes in humans. ..
- Phospholipid-Mediated Metabolic Control in Liver and Brown Adipose TissueDavid E Cohen; Fiscal Year: 2013..The proposed studies are relevant to the mission of the NIDDK because they are expected to identify new therapeutic targets for the management of common disorders related to diabetes and obesity. ..
- Mechanisms and metabolic implications of LRP130 in NAFLDMarcus P Cooper; Fiscal Year: 2013..This proposal will investigate the role of a gene called LRP130 in fatty liver disease, and may provide new ways to treat diabetes and heart disease. ..
- The Impact of Heat Shock Protein Expression on Inflammation and Insulin ActionAndrea L Hevener; Fiscal Year: 2013..skeletal muscle HSP72 levels, blunted JNK activity, and improved insulin sensitivity (as measured by the glucose clamp technique)...
- Role of Sirt1 in Regulating Glucose Homeostasis and Insulin Action in AgingCOLETTE M KNIGHT; Fiscal Year: 2012..Most significantly this study will assess how Sirtl function is altered in aging and its relationship to metabolic processes. ..
- Neonatal Programming of Growth and Maturation in Rhesus MonkeysAndrew Muir; Fiscal Year: 2013..A nonhuman primate model of gestational overnutrition is a vital resource to explore the effects of weight on the health of mothers, children, and perhaps even subsequent generations. ..
- Phosphoprotein CDP138 regulates glucose metabolismZHEN YUE JIANG; Fiscal Year: 2013..Together, this project will provide valuable and novel insight into the molecular mechanisms by which CDP138 acts as a point of convergence between kinase activation and glucose transport. ..
- Role of Perilipin in Hepatic Steatosis and MetabolismThomas A Bowman; Fiscal Year: 2013..These studies will guide the design of new therapeutic targets to prevent insulin resistance and treat type 2 diabetes. ..
- Skeletal muscle function and mitochondrial metabolism in non-diabetic CKDBaback Roshanravan; Fiscal Year: 2012..This understanding will ultimately identify a novel mechanism and provide an empiric basis for future large epidemiologic studies and clinical trials targeting mitochondrial dysfunction in CKD. ..
- Insulin Resistance in Chronic Kidney DiseaseIan H De Boer; Fiscal Year: 2013..These include the Institute for Translational Health Sciences Clinical Research Center, Nutrition and Body Composition Core, and Center for Biomedical Statistics. ..
- NEURAL RESPONSE TO INSULIN RESISTANCE TREATMENTSJASON J HASSENSTAB; Fiscal Year: 2013....
- A short course: An organ systems approach to target the Metabolic syndromeOwen P McGuinness; Fiscal Year: 2012..The benefit to human disease is that these trainees will now be equipped with the tools necessary to fill a void in our training programs. ..
- Effect of Circulating Glucose on Eating Behavior and Brain Activation in DiabetesRENATA D BELFORT DE AGUIAR; Fiscal Year: 2013..If granted this award, Dr. Belfort De Aguiar will be able to achieve her long term career goal of becoming a clinical translational scientist in the field of neuroscience/metabolism. ..
- EFFECT OF HIGH FRUCTOSE CORN SYRUP FEEDING IN NONALCOHOLIC FATTY LIVER DISEASEShelby A Sullivan; Fiscal Year: 2013....
- Maternal Overweight: Consequences for Insulin Signaling in the OffspringKartik Shankar; Fiscal Year: 2013..Overall, these studies will elucidate important metabolic mechanisms in the offspring altered by maternal OW and high-fat diets, which may contribute to increased susceptibility to obesity. ..
- Effects of sleep duration and architecture on insulin sensitivityMADHU NAGARAJU RAO; Fiscal Year: 2013..These findings may also lead to novel approaches to the treatment of insulin resistance, such as medications to alter sleep architecture or increase sleep duration. (End of Abstract) ..
- EFFECTS OF BARIATRIC SURGERY ON GLUCOSE HOMEOSTASIS IN TYPE-2 DIABETESSamuel Klein; Fiscal Year: 2012..We aim to determine the effects of surgical induced weight loss on glucose metabolism as it relates to the duration of T2DM diagnosis (recent vs. longstanding). ..
- Bioactives in Blueberries and Insulin ResistanceAPRIL STULL; Fiscal Year: 2013....
- Hepatic Rictor Knockout Mouse Model and the Metabolic SyndromeJENNIFER MARIE ROJAS; Fiscal Year: 2012..The possibility of hepatic steatosis will be assessed by liver lipid quantification. ..
- Race - adiposity interactions regulate mechanisms determining insulin sensitivityMichael J Quon; Fiscal Year: 2013..g., type 2 diabetes, cardiovascular disease, and cancer). ..
- Modulation of Insulin Action by Testosterone in MenNelly Pitteloud; Fiscal Year: 2010..Therefore, if low T levels are shown to play a role in the pathogenesis of insulin resistance, T may well represent an important therapeutic modality for both preventing and treating the metabolic syndrome and type 2 diabetes in men. ..
- DYSREGULATION OF GLUCOSE HOMEOSTASIS IN AGINGNIR J BARZILAI; Fiscal Year: 2013..Here we suggest that strategies designed to tip the balance of IGF-1 action from peripheral to brain may maximize the good effects of IGF-1 while minimizing the bad effects of IGF-1 on cancer risk, leading to healthy life-span. ..
- The Role of Ghrelin to Regulate Insulin Secretion in Health and Diabetes.Jenny Tong; Fiscal Year: 2013..The knowledge gained from this project will be pivotal in determining whether the ghrelin system can be used as a drug target for the treatment of T2DM. ..
- MECHANISMS OF INSULIN RESISTANCE IN MANRobert A Rizza; Fiscal Year: 2013..In particular, this application will focus on how and why the liver releases too much glucose into the blood stream causing blood sugars to rise both before and after eating. ..
- Adipocyte insulin signaling and circulating adiponectin levelsROCIO INES PEREIRA; Fiscal Year: 2010..The anticipated results of this clinical study may provide new insight into potential therapeutic targets in patients with T2DM, obesity, and MetS. ..
- Regulation of hepatic glucose production by Kruppel-like factor 15.SUSAN JESSICA GRAY; Fiscal Year: 2012..Studying the mechanism by which KLF15 controls hepatic glucose production and whole-body glucose homeostasis may lead to new therapies for the treatment of metabolic disorders such as diabetes. ..
- Insulin Resistance and Hepatic Steatosis in Hepatitis CCharles F Burant; Fiscal Year: 2010..abstract_text> ..
- UMass Mouse Metabolic Phenotyping CenterJason K Kim; Fiscal Year: 2013....
- Testosterone effects on insulin sensitivity &inflammation in T2DM and obesityParesh Dandona; Fiscal Year: 2012..The decrease in inflammation with testosterone treatment may have relevance for atherosclerosis and cardiovascular risk. ..
- PKA activation enhances insulin secretion to improve glucose homeostacis in agingKELLY ASAKO KAIHARA; Fiscal Year: 2012..The proposed studies will determine whether increased PKA signaling in ?- cells will improve ?-cell function and insulin secretory capacity in an aged population. ..
- Aerobic fitness, mitochondrial dysfunction, and fatty liver diseaseJohn P Thyfault; Fiscal Year: 2013..The outcomes will also if determine if increased hepatic mitochondrial content or increased hepatic fatty acid oxidation are effective therapeutic targets to prevent NAFLD or hepatic insulin resistance. ..
- Glucose Insulin and Muscle LossRita R Kalyani; Fiscal Year: 2013..These findings should establish a framework to evaluate the ability of existing diabetes therapies to preserve muscle and potentially identify new therapeutic targets. ..
- Effects of weight and insulin sensitivity on reproductive function in PCOSLEANNE MAREE REDMAN; Fiscal Year: 2013..It is hoped that further studies will then lead to the development of evidence based treatment programs for infertility in overweight women with PCOS. ..
- TAUROURSODEOXYCHOLIC ACID FOR PROTEASE-INHIBITOR ASSOCIATED INSULIN RESISTANCEDominic N Reeds; Fiscal Year: 2013..In addition to improving clinical care of people with HIV, the findings of this study may allow development of new drugs for treatment of type 2 diabetes. ..
- Are Overweight Children with T1DM at Increased Risk of Cardiovascular Disease?Ingrid M Libman; Fiscal Year: 2010..End of Abstract) ..
- GLUCOREGULATORY HORMONE INTERACTIONS IN DIABETESROBERT STANLEY SHERWIN; Fiscal Year: 2013..magnetic resonance imaging (fMRI) and magnetic resonance spectroscopy (MRS) in conjunction with the glucose clamp technique to assess the changes in brain function, neurotransmission and fuel metabolism causing the syndrome of ..
- A molecular basis for endotoxin mediated insulin resistanceSOPHIE HUSSEY; Fiscal Year: 2013..As such, our results could lead to the development of novel approaches for the treatment of this disease. ..
- Impaired adipogenesis in insulin resistance: pilot clinical and in-vitro studiesRichard E Pratley; Fiscal Year: 2010..This study tests whether differences in the growth rates of fat cells are related to the risk for diabetes in obese individuals. Results from this study could suggest new prevention / treatment strategies. ..
- Insulin resistance, amyloid, and memory in normal aging and preclinical ADJILL KATHLEEN MORRIS; Fiscal Year: 2013..By investigating insulin sensitivity in subjects with or without cerebral amyloidosis, we will determine whether these factors influence insulin- mediated cognitive improvement in the very earliest stages of AD. ..
- Mapping Genes for Atherosclerosis and Insulin ResistanceJerome I Rotter; Fiscal Year: 2010..Identifying the genes for CIMT and IR in this understudied population will provide new tools for risk assessment and prevention. ..
- Time Past Menopause, Duration of Estrogen Deficiency, and Insulin ActionRachael E Van Pelt; Fiscal Year: 2013..Confirmation of our hypotheses will provide evidence for a benefit of E2 on insulin action (GDR) when administered early, but not late, after menopause;likely contributing to delayed onset of T2DM. ..
- Metabolic, and Cardiovascular Effects of GHRH in HIV Infected PatientsSTEVEN KYLE GRINSPOON; Fiscal Year: 2012..We will also investigate whether the use of a secretory factor that induces the body to makes its own GH, growth hormone releasing hormone, will improve cardiovascular risk endpoints, including abdominal fat, insulin, and carotid IMT. ..
- Chlorolog: Production Scaling and Testing of a Fast-Acting, Ultra-stable InsulinBRUCE HILL FRANK; Fiscal Year: 2013..The present application thus provides a logical bridge between highly promising in vitro and animal data, as generated in the Phase 1 SBIR program, and key pre-IND milestones. ..
- ANABOLIC ACTIONS OF INSULIN IN NEUROMUSCULAR DISEASERICHARD MOXLEY; Fiscal Year: 1992..The present investigations will also provide additional new information about the actions of insulin on the regulation of protein metabolism in normal man...
- Trypanosoma cruzi and AIDS: Role of the AdipocyteHerbert Tanowitz; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Mechanisms Defending Fat Mass in Human after LipectomyRobert Eckel; Fiscal Year: 2007..abstract_text> ..
- Race, Lipoprotein Lipase and Obesity after MenopauseAndrew Goldberg; Fiscal Year: 2007..abstract_text> ..
- INSULIN RESISTANCE IN THE HIV LIPODYSTROPHY SYNDROMEColleen Hadigan; Fiscal Year: 2004....
- Increased Gluconeogenesis Is One Cause of CFRDDANA HARDIN; Fiscal Year: 2006..It is therefore expected that these studies will provide new information regarding potential causes of CF related diabetes and protein catabolism. ..
- The impact of PPAR-gamma and estrogen receptor crosstalk on insulin actionAndrea Hevener; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- PPAR Mediated Gene Expression in HIV PatientsMarie Gelato; Fiscal Year: 2007..abstract_text> ..
- INSULIN RESISTANCE AND GLUCOSE METABOLISM IN PREGNANCYPatrick Catalano; Fiscal Year: 1991..We then plan to test the value of improved treatment regimens based on the specific metabolic abnormality, to decrease maternal and perinatal morbidity...
- INSULIN RESISTANCE AND CALCIUM METABOLISM IN PREGNANCYJames Sowers; Fiscal Year: 1993....
- ALPHA AND BETA CELL FUNCTION IN HUMAN DIABETESJohn Gerich; Fiscal Year: 1993..Such knowledge could lead to better selection of patients for these regimens as well as the development of means to diminsh the risks for hypoglycemia...
- Insulin Resistance in Tissue Specific IKKB TransgenicsJongsoon Lee; Fiscal Year: 2004..These experiments will validate IKKbeta as a major mediator of insulin resistance and as a useful target for the discovery of new drugs to treat type 2 diabetes and insulin resistance. ..
- COUNTERREGULATORY FAILURE AND THE ARCUATE NUCLEUSNancy Tkacs; Fiscal Year: 2001....
- MENTORED ORIENTED RESEARCH CAREER DEVELOPMENT AWARDCrystal Gadegbeku; Fiscal Year: 2004..In addition, this research should lay the groundwork for new treatment strategies aimed to prevent vascular disease in the high cardiovascular risk patients. ..
- AEROBIC CAPACITY AND METABOLIC FUNCTION IN SENIORSAndrew Goldberg; Fiscal Year: 1992..These results will differentiate effects of primary from those of secondary aging and determine the mechanisms by which change in physical conditioning affects metabolic function...
- MANIPULATION OF INSULIN RESISTANCE IN TRANSGENIC MICEBESS MARSHALL; Fiscal Year: 1999..These mice will be studied using glucose clamp and tracer techniques to evaluate the impact of an increase in glucokinase on hepatic insulin sensitivity. ..
- INSULIN ACTION IN CYSTIC FIBROSISDANA HARDIN; Fiscal Year: 1999..Dennis Bier, who will provide extensive knowledge regarding the use of stable isotopes, and use of the USDA/ARS Children's Nutrition Research Center will provide an important addition to Dr. Hardin's research training. ..
- Diabetes, Exercise and Postprandial Oxidative StressLauretta Quinn; Fiscal Year: 2005..This study represent a novel approach to the use of aerobic exercise in the treatment of type 2 DM, providing data for future investigations and exercise training studies in this area. ..
- COMPARATIVE STUDIES OF INTRACELLULAR GLUCOSE METABOLISMRobert Henry; Fiscal Year: 1992..To conduct these studies the insulin-glucose clamp technique will be employed to measure glucose uptake rates in conjunction with simultaneous computerized open ..