transplants

Summary

Summary: Organs, tissues, or cells taken from the body for grafting into another area of the same body or into another individual. (From Dorland, 28th ed)

Top Publications

  1. pmc Evolving approaches of hematopoietic stem cell-based therapies to induce tolerance to organ transplants: the long road to tolerance
    J Leventhal
    Comprehensive Transplant Center, Northwestern Memorial Hospital, Chicago, Illinois, USA
    Clin Pharmacol Ther 93:36-45. 2013
  2. ncbi Measuring patient-reported outcomes in solid organ transplant recipients: an overview of instruments developed to date
    Irina Cleemput
    Belgian Health Care Knowledge Centre KCE, Brussels, Belgium
    Pharmacoeconomics 25:269-86. 2007
  3. pmc Comparison and temporal trends of three groups with cryptococcosis: HIV-infected, solid organ transplant, and HIV-negative/non-transplant
    Emily W Bratton
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 7:e43582. 2012
  4. pmc Dissociation between peripheral blood chimerism and tolerance to hindlimb composite tissue transplants: preferential localization of chimerism in donor bone
    Dina N Rahhal
    Institute for Cellular Therapeutics, University of Louisville, Louisville, KY 40202 1760, USA
    Transplantation 88:773-81. 2009
  5. ncbi Gene therapy in tissue-engineered blood vessels
    Ryan C Fields
    Department of Surgery and Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Tissue Eng 9:1281-7. 2003
  6. pmc Binding immunoglobulin protein resolves rheumatoid synovitis: a xenogeneic study using rheumatoid arthritis synovial membrane transplants in SCID mice
    Kaoru Yoshida
    Biomedical Engineering Center, Toin University of Yokohama, 1614 Kurogane cho, Aoba ku, Yokohama 225 8502, Japan
    Arthritis Res Ther 13:R149. 2011
  7. ncbi Green fluorescent protein is a stable morphological marker for schwann cell transplants in bioengineered nerve conduits
    Mel P Tohill
    Blond McIndoe Research Laboratories, University of Manchester, Manchester, UK
    Tissue Eng 10:1359-67. 2004
  8. ncbi Polyomavirus-associated nephropathy risk in kidney transplants: the influence of recipient age and donor gender
    H A Khamash
    Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Kidney Int 71:1302-9. 2007
  9. ncbi Continuous exposure to glial cell line-derived neurotrophic factor to mature dopaminergic transplants impairs the graft's ability to improve spontaneous motor behavior in parkinsonian rats
    C Winkler
    Department of Experimental Medical Science, Section of Neuroscience, CNS Disease Modeling Unit, Lund University, BMCA11, S 22184 Lund, Sweden
    Neuroscience 141:521-31. 2006
  10. ncbi Invasive fungal infections among organ transplant recipients: results of the Transplant-Associated Infection Surveillance Network (TRANSNET)
    Peter G Pappas
    Division of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham Medical Center, Birmingham, Alabama 35294 0006, USA
    Clin Infect Dis 50:1101-11. 2010

Detail Information

Publications241 found, 100 shown here

  1. pmc Evolving approaches of hematopoietic stem cell-based therapies to induce tolerance to organ transplants: the long road to tolerance
    J Leventhal
    Comprehensive Transplant Center, Northwestern Memorial Hospital, Chicago, Illinois, USA
    Clin Pharmacol Ther 93:36-45. 2013
    ..This review presents a historic perspective of the quest for tolerance in organ transplantation, highlighting current clinical approaches...
  2. ncbi Measuring patient-reported outcomes in solid organ transplant recipients: an overview of instruments developed to date
    Irina Cleemput
    Belgian Health Care Knowledge Centre KCE, Brussels, Belgium
    Pharmacoeconomics 25:269-86. 2007
    ....
  3. pmc Comparison and temporal trends of three groups with cryptococcosis: HIV-infected, solid organ transplant, and HIV-negative/non-transplant
    Emily W Bratton
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 7:e43582. 2012
    ..However, direct comparisons of management, severity and outcomes of these groups have not been conducted...
  4. pmc Dissociation between peripheral blood chimerism and tolerance to hindlimb composite tissue transplants: preferential localization of chimerism in donor bone
    Dina N Rahhal
    Institute for Cellular Therapeutics, University of Louisville, Louisville, KY 40202 1760, USA
    Transplantation 88:773-81. 2009
    ..Mixed chimerism induces donor-specific tolerance to composite tissue allotransplants (CTAs). In the present studies, we used a nonmyeloablative conditioning approach to establish chimerism and promote CTA acceptance...
  5. ncbi Gene therapy in tissue-engineered blood vessels
    Ryan C Fields
    Department of Surgery and Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Tissue Eng 9:1281-7. 2003
    ..This also provides the framework for testing an array of genes that may improve the function of engineered blood vessels after surgical implantation...
  6. pmc Binding immunoglobulin protein resolves rheumatoid synovitis: a xenogeneic study using rheumatoid arthritis synovial membrane transplants in SCID mice
    Kaoru Yoshida
    Biomedical Engineering Center, Toin University of Yokohama, 1614 Kurogane cho, Aoba ku, Yokohama 225 8502, Japan
    Arthritis Res Ther 13:R149. 2011
    ....
  7. ncbi Green fluorescent protein is a stable morphological marker for schwann cell transplants in bioengineered nerve conduits
    Mel P Tohill
    Blond McIndoe Research Laboratories, University of Manchester, Manchester, UK
    Tissue Eng 10:1359-67. 2004
    ..These findings show that GFP labeling does not have a deleterious effect on SCs and that it is a useful labeling method for the study of bioengineered systems...
  8. ncbi Polyomavirus-associated nephropathy risk in kidney transplants: the influence of recipient age and donor gender
    H A Khamash
    Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Kidney Int 71:1302-9. 2007
    ..We conclude that PVAN preferentially affects older age patients and allografts from female donors but is unrelated to immunological risk, choice of immunosuppression, or rejection history...
  9. ncbi Continuous exposure to glial cell line-derived neurotrophic factor to mature dopaminergic transplants impairs the graft's ability to improve spontaneous motor behavior in parkinsonian rats
    C Winkler
    Department of Experimental Medical Science, Section of Neuroscience, CNS Disease Modeling Unit, Lund University, BMCA11, S 22184 Lund, Sweden
    Neuroscience 141:521-31. 2006
    ..Rats with dopamine-denervating lesions received multiple intrastriatal transplants of fetal dopaminergic cells and graft-induced behavioral effects were analyzed in drug-induced and spontaneous ..
  10. ncbi Invasive fungal infections among organ transplant recipients: results of the Transplant-Associated Infection Surveillance Network (TRANSNET)
    Peter G Pappas
    Division of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham Medical Center, Birmingham, Alabama 35294 0006, USA
    Clin Infect Dis 50:1101-11. 2010
    ..Invasive fungal infections (IFIs) are a major cause of morbidity and mortality among organ transplant recipients. Multicenter prospective surveillance data to determine disease burden and secular trends are lacking...
  11. pmc Lipid formulations of amphotericin B significantly improve outcome in solid organ transplant recipients with central nervous system cryptococcosis
    Hsin Yun Sun
    VA Pittsburgh Healthcare System, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Clin Infect Dis 49:1721-8. 2009
    ....
  12. ncbi Serotonergic neurons mediate dyskinesia side effects in Parkinson's patients with neural transplants
    Marios Politis
    Centre for Neuroscience, Division of Experimental Medicine, Faculty of Medicine, Hammersmith Hospital, Imperial College London, London W12 0NN, UK
    Sci Transl Med 2:38ra46. 2010
    ..Our observations suggest strategies for avoiding and treating graft-induced dyskinesias that result from cell therapies for Parkinson's disease with fetal tissue or stem cells...
  13. pmc Cryptococcosis in solid organ transplant recipients: current state of the science
    Nina Singh
    University of Pittsburgh, Pennsylvania, USA
    Clin Infect Dis 47:1321-7. 2008
    ..This review summarizes the current state of knowledge regarding cryptococcosis in transplant recipients and highlights areas where future investigations are needed to further optimize outcomes for these patients...
  14. ncbi Delayed olfactory ensheathing cell transplants reduce nociception after dorsal root injury
    Ann Wu
    Neural Injury Research Unit, School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia
    Exp Neurol 229:143-57. 2011
    ..The anti-nociceptive effect mediated by OEC transplants may therefore be explained by alternative mechanisms such as modification of inflammation and astrogliosis...
  15. ncbi Standards for the terminology and labeling of cellular therapy products
    Paul Ashford
    International Cellular Therapy Coding and Labeling Advisory Group, Redlands, CA 92374, USA
    Transfusion 47:1319-27. 2007
  16. ncbi ISBT 128 implementation plan for cellular therapy products
    Paul Ashford
    J Clin Apher 22:258-64. 2007
    ..This paper provides guidance on the practical aspects of adopting these new standards for organizations with differing current levels of computerization. It discusses project management, equipment, licensing, and validation topics...
  17. ncbi ISBT 128 implementation plan for cellular therapy products
    Paul Ashford
    International Cellular Therapy Coding and Labeling Advisory Group, Redlands, CA 92374, USA
    Transfusion 47:1312-8. 2007
  18. ncbi Standards for the terminology and labeling of cellular therapy products
    Paul Ashford
    J Clin Apher 22:249-57. 2007
  19. ncbi The clinical utility of whole blood versus plasma cytomegalovirus viral load assays for monitoring therapeutic response
    Luiz F Lisboa
    Department of Medicine, University of Alberta, Edmonton, AB, Canada
    Transplantation 91:231-6. 2011
    ..We compared a whole blood real-time PCR with a plasma PCR assay for monitoring therapeutic response...
  20. ncbi An experiment-based model of vein graft remodeling induced by shear stress
    Roger Tran-Son-Tay
    Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, FL 32611, USA
    Ann Biomed Eng 36:1083-91. 2008
    ..Other mechanical and biological factors can be included following a similar approach in order to obtain a more accurate vein graft remodeling model...
  21. ncbi New perfusion imaging of tissue transplants with Contrast Harmonic Ultrasound Imaging (CHI) and Magnetic Resonance Imaging (MRI) in comparison with laser-induced Indocyanine Green (ICG) fluorescence angiography
    E M Jung
    Institute of Radiology, University Medical Center Regensburg, Regensburg, Germany
    Clin Hemorheol Microcirc 43:19-33. 2009
    ..Evaluation of post-surgery tissue perfusion of free flaps of the lower leg with contrast enhanced harmonic imaging (CHI), laser-induced indocyanine green (ICG) fluorescence angiography and magnetic resonance imaging (MRI)...
  22. ncbi Deafferentation pain resulting from cervical posterior rhizotomy is alleviated by chromaffin cell transplants into the rat spinal subarachnoid space
    Marc Guenot
    Neurosurgery 60:919-25; discussion 919-25. 2007
    ..Previous work has demonstrated that adrenal medullary transplants into the lumbar spinal subarachnoid space can alleviate neuropathic pain behavior resulting from peripheral ..
  23. pmc Transplanted dopamine neurons derived from primate ES cells preferentially innervate DARPP-32 striatal progenitors within the graft
    Daniela Ferrari
    McLean Hospital Harvard University Udall Parkinson s Disease Research Center of Excellence, 115 Mill St, Belmont, MA 02478, USA
    Eur J Neurosci 24:1885-96. 2006
    ..Despite the heterogeneity of ES-derived graft cell composition, these results demonstrate normal phenotypic specification, conserved natural axonal target selectivity and functionality of DA neurons derived from primate ES cells...
  24. ncbi Musculoskeletal allograft risks and recalls in the United States
    Thomas E Mroz
    Neuroscience Institute, Center for Spine Health, The Cleveland Clinic, OH 44195, USA
    J Am Acad Orthop Surg 16:559-65. 2008
    ..Infectious disease transmission following allograft implantation may occur if potential donors are not adequately evaluated or screened serologically during the prerecovery phase and if the implant is not sterilized before implantation...
  25. ncbi Biomechanical properties of commonly used autogenous transplants in the surgical treatment of chronic lateral ankle instability
    Michael Bohnsack
    Department of Orthopaedic Surgery, Hannover Medical School, Germany
    Foot Ankle Int 23:661-4. 2002
    The purpose of this study was to evaluate the biomechanical properties of commonly used autogenous transplants for the surgical stabilization of chronic lateral ankle instability...
  26. ncbi Surgeons struggle with ethical nightmare of face transplants
    Natasha McDowell
    Nature 420:449. 2002
  27. ncbi Use of Sertoli cell transplants to provide local immunoprotection for tissue grafts
    Craig Halberstadt
    Carolinas Medical Center, General Surgery Research, Cannon Research Center, P O Box 32861, Charlotte, NC 28232 2861, USA
    Expert Opin Biol Ther 4:813-25. 2004
    ....
  28. ncbi Allocation of deceased donor kidneys for transplantation: opinions of patients with CKD
    Colin C Geddes
    Renal Unit, Western Infirmary, University of Glasgow, Scotland
    Am J Kidney Dis 46:949-56. 2005
    ..The aim of this single-center survey is to seek patient opinion about the relative importance of factors used to determine the optimal transplant recipient in kidney allocation schemes...
  29. ncbi Collagen nerve conduits--assessment of biocompatibility and axonal regeneration
    Felix Stang
    Institute of Medical Neurobiology and Department of Plastic, Reconstructive and Hand Surgery, University of Magdeburg, Germany
    Biomed Mater Eng 15:3-12. 2005
    ..From these results, we conclude that a sufficient biocompatibility of bioartificial nerve conduits is a necessary prerequisite, however, it remains only one of several parameters important for peripheral nerve regeneration...
  30. ncbi Dual kidneys from marginal adult donors as a source for cadaveric renal transplantation in the United States
    Suphamai Bunnapradist
    Center for Kidney and Kidney Pancreas Transplantation, Burns Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    J Am Soc Nephrol 14:1031-6. 2003
    The current organ shortage has led to the utilization of double kidney transplants from marginal adult donors, but outcomes data are limited...
  31. ncbi Detection of HLA-G in serum and graft biopsy associated with fewer acute rejections following combined liver-kidney transplantation: possible implications for monitoring patients
    Caroline Creput
    Service de Recherches en Hemato Immunologie, Hopital Saint Louis, IUH, Paris, France
    Hum Immunol 64:1033-8. 2003
    ..This suggests that it participates in the acceptance of allogeneic organ transplants in humans...
  32. ncbi Biomaterial mesh seeded with vascular remnants from a quail embryo has a significant and fast vascular templating effect on host implant tissue
    J E Sanders
    Department of Bioengineering, University of Washington, Seattle, Washington 98195, USA
    Tissue Eng 9:1271-9. 2003
    ..Tissue engineering of vessel templates may thus be a realistic solution to effective fast vascularization of biomaterials...
  33. ncbi Effect of implantation site on hepatocytes heterotopically transplanted on biodegradable polymer scaffolds
    Hanmin Lee
    Department of Surgery, University of California at San Francisco, San Francisco, California 94143, USA
    Tissue Eng 9:1227-32. 2003
    ..The omentum is the most favorable bed for engraftment of hepatocyte-polymer tissue-engineered constructs and the addition of a portacaval shunt increases survival of transplanted hepatocytes in the omentum and mesentery...
  34. ncbi Angiogenesis in tissue-engineered small intestine
    James Gardner-Thorpe
    Department of Surgery, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Tissue Eng 9:1255-61. 2003
    ..48 versus 162.3 +/- 15.09 pg/mg; p < 0.05). The mechanism driving angiogenesis differs in engineered intestine and in normal bowel. VEGF and bFGF delivery may prove useful for bioengineering of intestine...
  35. ncbi The problem of transplanting the sensitized patient: whose problem is it?
    Annette M Jackson
    Immunogenetics Laboratory, Johns Hopkins University School of Medicine, 2041 E Monument Street, Baltimore, MD 21205 2222, USA
    Front Biosci 13:1396-412. 2008
    ..Thus, sensitization to HLA antigens is a problem for the patient, the transplant physician, and the histocompatibility laboratory...
  36. ncbi Growing pains: non-adherence with the immunosuppressive regimen in adolescent transplant recipients
    Fabienne Dobbels
    Center for Health Services and Nursing Research, Katholieke Universiteit Leuven, Leuven, Belgium
    Pediatr Transplant 9:381-90. 2005
    ....
  37. ncbi The interaction of Schwann cells with chitosan membranes and fibers in vitro
    Ying Yuan
    The Jiangsu Key Laboratory of Neuroregeneration, Nantong Medical College, Nantong, Jiangsu 226001, PR China
    Biomaterials 25:4273-8. 2004
    ..Compared with the chitosan membranes, SCs migrated more easily onto the stereoframe of chitosan fibers. These studies contribute information necessary to enhancing our understanding of biocompatibility of chitosan...
  38. ncbi Capillary deposition of complement C4d and C3d in pediatric renal allograft biopsies
    Jean Herman
    Department of Pediatric Transplantation, University Hospitals Leuven, 3000 Leuven, Belgium
    Transplantation 79:1435-40. 2005
    ..C3d(PTC) has received less attention; its significance is unclear. To date no information has been gained in children...
  39. ncbi The use of a supercooling refrigerator improves the preservation of organ grafts
    Koshiro Monzen
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Bunkyo ku, Japan
    Biochem Biophys Res Commun 337:534-9. 2005
    ..Our results suggest that the use of this supercooling refrigerator improves organ preservation and may provide an innovative technique for human organ transplantation...
  40. ncbi Haematopoietic graft engineering
    W Y K Hwang
    Department of Haematology, Singapore General Hospital, Singapore
    Ann Acad Med Singapore 33:551-8. 2004
    ..While the science is still prepubescent, it has passed its infancy and further developments in the next decade or so should allow it to be taken to a wider scale to benefit more patients...
  41. ncbi Use of two biomarkers of renal ischemia to assess machine-perfused non-heart-beating donor kidneys
    Muhammed A Gok
    Department of Surgery, The Medical School, University of Newcastle, Newcastle upon Tyne NE7 7DN, England
    Clin Chem 49:172-5. 2003
  42. ncbi Organotypic keratinocyte-fibroblast cocultures on a bilayer gelatin scaffold as a model of skin equivalent
    Tzu Wei Wang
    Graduate Institute of Biomedical Engineering, College of Medicine, National Taiwan University, No 1, Jen Ai Road, Taipei, Taiwan, R O C
    Biomed Sci Instrum 39:523-8. 2003
    ..It is suggested that the bi-layer scaffolds have the potential to be used as skin equivalents for application in burn wounds. In the future, the qualitative of chemical reagents and in vivo animal model tests will be evaluated...
  43. ncbi Engineered adipose tissue supplied by functional microvessels
    Joerg Borges
    Department of Plastic and Hand Surgery, Medical Center, University of Freiburg, Germany
    Tissue Eng 9:1263-70. 2003
    ..The cotransplantation of endothelial cell spheroids with angiogenic mesenchymal cells may lead to the engineering of complex three-dimensional implants...
  44. ncbi Cultured keratinocytes and dermal fibroblasts on a double-layer scaffold with bi-medium culture system
    Yi Chau Huang
    Graduate Institute of Biomedical Engineering, College of Medicine, National Taiwan University, No 1, Jen Ai Road, Taipei, Taiwan, R O C
    Biomed Sci Instrum 39:500-5. 2003
    ..It is suggested that epidermal keratinocytes with bimedium culture system developed the basement membrane and also differentiated upward in the form of multi-layers...
  45. ncbi Optimized acellular nerve graft is immunologically tolerated and supports regeneration
    Terry W Hudson
    Department of Chemical Engineering, University of Texas at Austin, Austin, Texas, USA
    Tissue Eng 10:1641-51. 2004
    ..In summary, the results imply that OA grafts are immunologically tolerated and that the removal of cellular material and preservation of the matrix are beneficial for promoting regeneration through an acellular nerve graft...
  46. ncbi [Study of renal transplant by deconvoluted renogram with 99m Tc-mercaptoacetyltriglycine (Mag3)]
    M T Bajen
    Servicios de Medicina Nuclear y Nefrología, Hospital Princeps d Espanya, CSUB, L Hospitalet de Llobregat, Barcelona, Spain
    Rev Esp Med Nucl 20:453-61. 2001
    ..To evaluate the usefulness of the 99mTc-MAG3 renogram deconvolution and its derived parameters in kidney graft function monitoring...
  47. ncbi C4d deposition in peritubular capillary and alloantibody in the allografted kidney suffering severe acute rejection
    Masahiro Abe
    Departments of Surgery, Tokyo Women s Medical University, Tokyo, Japan
    Clin Transplant 17:14-9. 2003
    ..The purpose of this study was to evaluate the relationship between C4d deposition in PTCs and alloantibodies at various days after allograft dysfunction due to severe acute rejection...
  48. ncbi Histological evaluation of renal allograft protocol biopsies in the early period and 1 year after transplantation
    Yukiko Kanetsuna
    Department of Clinical Pathology, Jikei University, Kashiwa Hospital, Japan
    Clin Transplant 17:25-9. 2003
    ..The 1-year biopsy was useful for evaluating various types of chronic graft damage. We expect that adequate treatment based on protocol biopsy findings in each patient will lead to better graft survival...
  49. ncbi Kidneys from deceased donors: maximizing the value of a scarce resource
    Herwig Ulf Meier-Kriesche
    Department of Medicine, University of Florida, Gainesville, FL, USA
    Am J Transplant 5:1725-30. 2005
    ..We examined patient and graft survival for deceased donor kidney transplants performed in the United States between the years 1990 and 2002 by Kaplan-Meier plots...
  50. ncbi Arcuate and interlobular phlebitis in renal allografts
    M Torbenson
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD, USA
    Hum Pathol 32:1388-91. 2001
    ..However, this lesion frequently coexists with changes suggestive or diagnostic of acute cellular rejection, and intimal arteritis may be seen concurrently in up to 16% of cases...
  51. ncbi The spectrum of antibody-mediated renal allograft injury: implications for treatment
    J Gloor
    Department of Nephrology and Internal Medicine, Mayo Clinic and Foundation, Rochester, MN, USA
    Am J Transplant 8:1367-73. 2008
    ..Although effective therapy is available for acute AMR, allografts remain at risk for chronic AMR and shortened survival. The optimum approach to treatment for chronic AMR remains to be determined...
  52. ncbi Are we frozen in time? Analysis of the utilization and efficacy of pulsatile perfusion in renal transplantation
    Jesse D Schold
    Department of Medicine, University of Florida, Gainesville, FL, USA
    Am J Transplant 5:1681-8. 2005
    ..Additional evidence of improvement in graft survival, particularly in more recent years, provides further encouraging evidence for the use of PP...
  53. ncbi Liver transplant for hepatitis C virus: effect of using older donor grafts on short- and medium-term survival
    M B Majella Doyle
    Department of Surgery, Section of Abdominal Transplantation, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Arch Surg 143:679-85; discussion 685. 2008
    ..In addition, recent studies suggest that the use of older donors in recipients with HCV is associated with significantly worsened short- and long-term survival...
  54. ncbi Use of elderly donors (> 60 years) for liver transplantation
    Yi Zhao
    Centre for the Study of Liver Disease and Department of Surgery, The University of Hong Kong, Medical Centre, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong SAR, China
    Asian J Surg 27:114-9. 2004
    ..In this study, we reviewed our experience of using elderly brain-dead donor livers, investigating the potential prognostic factors of the donor, and analysing the influence of donor age on early graft function and graft survival...
  55. ncbi Delayed graft function may not adversely affect short-term renal allograft outcome
    Barry J Browne
    Department of Surgery, Baystate Medical Center, Springfield, MA, USA
    Clin Transplant 17:35-8. 2003
    ..We therefore prospectively sought to examine the natural history of DGF in a controlled patient population under identical immunosuppressive protocols...
  56. ncbi The utility of marginal donors in liver transplantation
    Ronald W Busuttil
    Department of Surgery, Division of Liver and Pancreas Transplantation, Dumont UCLA Transplant Center, Los Angeles, CA 90095, USA
    Liver Transpl 9:651-63. 2003
    ..Finally, new strategies for improving the function of the marginal/expanded donor liver will be reviewed...
  57. ncbi Animal models of spinal cord injury for evaluation of tissue engineering treatment strategies
    R Talac
    Departments of Orthopaedic Surgery and Biomedical Engineering, Mayo Clinic and Mayo Medical School, Medical Sciences Building Room 3 69, 200 1st Street SW, Rochester, MN 55905, USA
    Biomaterials 25:1505-10. 2004
    ..This discussion includes diverse causes, pathology and functional consequences of human SCI, general and species related considerations, technical and animal care considerations, and data analysis methods...
  58. ncbi The development of kidney allocation policy
    Mark D Stegall
    Am J Kidney Dis 46:974-5. 2005
  59. ncbi Review of nonimmunological causes for deteriorated graft function and graft loss after transplantation
    Johann Pratschke
    Department of General, Visceral and Transplantation Surgery, Universitatsmedizin Berlin, Berlin, Germany
    Transpl Int 21:512-22. 2008
    ..We review nonimmunological causes for deteriorated graft function and graft loss after solid organ transplantation...
  60. ncbi The impact of human leukocyte antigen matching on transplant complications and immunosuppression dosage
    Selda Emre Aydingoz
    Center for Outcomes Research, Department of Internal Medicine, Saint Louis University, Saint Louis, MO 63104, USA
    Hum Immunol 68:491-9. 2007
    ..We break from tradition by examining HLA matching in both living and deceased donor kidney transplants. As secondary aims, we compare the relative impact of class I and II mismatches and describe outcomes achieved ..
  61. ncbi Transplantation of yeast-infected cardiac allografts: a report of 2 cases
    Reto Gamma
    Department of Cardiology, Swiss Cardiovascular Center Bern
    J Heart Lung Transplant 24:1159-62. 2005
    ..We discuss the possible routes of donor organ infection and management of these 2 unusual cases...
  62. ncbi Rabies transmission from organ transplants in the USA
    Bernhard Dietzschold
    Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Lancet 364:648-9. 2004
  63. ncbi Structure and function of embryonic rat retinal sheet transplants
    Qing Peng
    Department of Ophthalmology, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, People s Republic of China
    Curr Eye Res 32:781-9. 2007
    To evaluate retinal sheet transplants in S334ter-line-3 retinal degenerate rats by comparing visual responses recorded electrophysiologically with morphology based on light and electron microscopy.
  64. ncbi Evaluation of transplantation in one center: Akdeniz University model
    M Tuncer
    Akdeniz University, Antalya, Turkey
    Transplant Proc 34:2012-3. 2002
  65. ncbi Origin of regenerated axons in nerve bypass grafts
    Nobuyuki Tanigawa
    Department of Orthopedic Surgery, Kansai Medical University, Osaka, Japan
    J Neurotrauma 22:605-12. 2005
    ....
  66. ncbi Transplant recipients' conceptions of three key phenomena in transplantation: the organ donation, the organ donor, and the organ transplant
    Margareta A Sanner
    Department of Public Health and Caring Sciences, Unit of Health Services Research, Uppsala Science Park, Uppsala, Sweden
    Clin Transplant 17:391-400. 2003
    ..The selection of informants was designed to permit comparisons between recipients with heart and kidney transplants and with living and necro-transplants...
  67. ncbi Conscription of cadaveric organs: we need to start talking about it
    Aaron Spital
    Am J Transplant 5:1170-1. 2005
  68. ncbi How should we ethically select living kidney donors when they all are at risk?
    Robert Steiner
    Am J Transplant 5:1172-3. 2005
  69. ncbi System-engineered cartilage using poly(N-isopropylacrylamide)-grafted gelatin as in situ-formable scaffold: in vivo performance
    Shinichi Ibusuki
    Department of Biomedical Engineering, Graduate School of Medicine, Kyushu University, Fukuoka, Japan
    Tissue Eng 9:1133-42. 2003
    ..The score on gross examination showed that transplants with precultured tissue acquired a higher score than did the others...
  70. ncbi Long-term consequences of live kidney donation follow-up in 93% of living kidney donors in a single transplant center
    Jan Gossmann
    Transplantationsambulanz, KfH Nierenzentrum, Schleusenweg 22, 60528 Frankfurt, Germany
    Am J Transplant 5:2417-24. 2005
    ..Because of the high incidence of proteinuria and possible changes in bone metabolism inclusion of kidney donors in registries appears worthwhile...
  71. ncbi Grafts of porcine intestinal submucosa for repair of cervical and abdominal esophageal defects in the rat
    Maria Francelina Lopes
    Laboratory of Experimental Research of the University Hospital of Coimbra, Coimbra, Portugal
    J Invest Surg 19:105-11. 2006
    ..In the rat model, a patch graft technique using porcine SIS appears to induce esophageal regrowth either in cervical and abdominal esophagus. The repair mechanism occurred through a regenerative healing process...
  72. ncbi Tourniquet compression: a non-invasive method to enhance nerve regeneration in nerve grafts
    Annika Widerberg
    Department of Hand Surgery, Malmo University Hospital, SE 205 02 Malmo, Sweden
    Neuroreport 13:371-5. 2002
    ..Tourniquet compression may be used as a non-invasive method to enhance nerve regeneration in nerve grafts...
  73. ncbi [Report from the Japan organ transplant network]
    Yasushi Asano
    Nihon Jinzo Gakkai Shi 47:517-23. 2005
  74. ncbi Improvement of recipient survival after small size graft liver transplantation in rats with preischemic manipulation or administering antisense against nuclear factor-kappaB
    Jiang Ming Qian
    Liver Transplant Section, Center for Organ Transplantation, Huashan Hospital, Fudan University, Shanghai, China
    Transpl Int 20:784-9. 2007
    ....
  75. ncbi Donor graft adenoviral iNOS gene transfer ameliorates rat liver transplant preservation injury and improves survival
    Takashi Kaizu
    Department of Surgery, Thomas E Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Hepatology 43:464-73. 2006
    ..Downregulation of ICAM-1 mRNA and neutrophil infiltration may be associated with the mechanisms by which AdiNOS pretreatment confer the protection against transplant-associated hepatic I/R injury...
  76. ncbi Role of thymic- and graft-dependent mechanisms in tolerance induction to rat kidney transplant by donor PBMC infusion
    R A Cavinato
    Transplant Research Center, Chiara Cucchi De Alessandri and Gilberto Crespi, Azienda Ospedaliera, Ospedali Riuniti di Bergamo Mario Negri Institute for Pharmacological Research, Bergamo, Italy
    Kidney Int 71:1132-41. 2007
    ..The healed graft is a source of donor antigens, which led to early selection of Treg. In the late phase, tolerance is maintained by appearance of Treg in LN...
  77. ncbi Outcome of renal transplantation in eight patients with Candida sp. contamination of preservation fluid
    M Matignon
    Nephrology Unit, Henri Mondor Hospital, AP HP, Institut Francilien de Techerche en Néphrologie et Transplantation IFRNT and Paris XII University, Creteil, France
    Am J Transplant 8:697-700. 2008
    ..Until other risk factors for vascular complications have been determined, early antifungal treatment and repeated radiological monitoring are advisable for the prevention and/or early detection of such complications...
  78. ncbi Assessment of donor liver steatosis: pathologist or automated software?
    Hendrik Marsman
    Division of Transplantation Surgery, Mayo Clinic, Rochester, MN, USA
    Hum Pathol 35:430-5. 2004
    ..Further study is needed to determine the role of an automated technique in the evaluation of donor livers for transplantation...
  79. ncbi In vivo conjunctival reconstruction using modified PLGA grafts for decreased scar formation and contraction
    Sang Young Lee
    Biomaterials Research Center, Korea Institute of Science and Technology, Seoul 130 650, Republic of Korea
    Biomaterials 24:5049-59. 2003
    ..Our results indicated that the modified PLGA graft as an acellular bed might allow the reconstruction of the damaged conjunctival tissue with less scar formation and contraction...
  80. ncbi Fabrication of mitral valve chordae by directed collagen gel shrinkage
    Yaling Shi
    Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Tissue Eng 9:1233-42. 2003
    ..These structures may have application in other areas that require small-diameter tendons...
  81. ncbi Tissue-transplant fusion and vascularization of myocardial microtissues and macrotissues implanted into chicken embryos and rats
    Jens M Kelm
    Institute for Chemical and Bio Engineering, Swiss Federal Institute of Technology, Zurich, Switzerland
    Tissue Eng 12:2541-53. 2006
    ..Myocardial microtissues and custom-shaped macrotissues produced by cellular self-assembly exemplify the potential of artificial tissue implants for regenerative medicine...
  82. ncbi In vitro characterization of a bone marrow stem cell-seeded collagen gel composite for soft tissue grafts: effects of fiber number and serum concentration
    K E Lewus
    Department of Biomedical Engineering, Tulane University, New Orleans, Louisiana, USA
    Tissue Eng 11:1015-22. 2005
    ..By using short collagen fibers to create a collagen composite gel, preservation of the original dimensions can be achieved without compromising cellular viability...
  83. ncbi Incorporation of intact elastin scaffolds in tissue-engineered collagen-based vascular grafts
    Joseph D Berglund
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    Tissue Eng 10:1526-35. 2004
    ..Future challenges include stimulating appropriate reorganization or synthesis of the collagen matrix to provide the necessary strength and viscoelastic properties for implantation...
  84. ncbi Properties of engineered vascular constructs made from collagen, fibrin, and collagen-fibrin mixtures
    Christopher L Cummings
    Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Biomaterials 25:3699-706. 2004
    ..These results demonstrate that the properties of engineered vascular tissues can be modulated by the combination of selected extracellular matrix components, and the application of mechanical stimulation...
  85. ncbi Gene transfer of interleukin-18-binding protein attenuates cardiac allograft rejection
    Jean Dudler
    Department of Rheumatology, CHUV University Hospital, Lausanne, Switzerland
    Transpl Int 20:460-6. 2007
    ..These results suggest a contributory role for IL-18 in acute rejection. Further studies aiming at defining the therapeutic potential of IL-18BP are warranted...
  86. ncbi Characterization of statically loaded tissue-engineered mitral valve chordae tendineae
    Yaling Shi
    Department of Biomedical Engineering, ND20, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    J Biomed Mater Res A 69:26-39. 2004
    ..This study has demonstrated that collagen-cell constructs, with material properties and microstructure similar to native mitral valve chordae, can be developed using static culture...
  87. ncbi Effect of anti-CD 20 antibody rituximab in patients with post-transplant lymphoproliferative disorder (PTLD)
    S H K Oertel
    University Medicine of Berlin, Charite Campus Virchow Clinic, Department of Internal Medicine, Berlin, Germany
    Am J Transplant 5:2901-6. 2005
    ..Two patients relapsed, at intervals 3 and 5 months after obtaining complete remission. Rituximab proved to be well tolerated and effective in the treatment of PTLD...
  88. ncbi Progress toward production of immunologic tolerance with no or minimal toxic immunosuppression for prevention of immunodeficiency and autoimmune diseases
    R A Good
    Department of Pediatrics, University of South Florida All Children s Hospital, St Petersburg, FL 33701, USA
    World J Surg 24:797-810. 2000
    ..deficiencies caused by fatal irradiation without producing GVHD if the bone marrow (BM) used for the transplants has been purged of postthymic T cells. Over two decades in conjunction with Ikehara et al...
  89. ncbi Transplantation of fetal liver tissue suspension into the spleens of adult syngenic rats: effects of different cytotoxins on cytochrome P450 isoforms expression and on glycogen content
    A Lupp
    Institute of Pharmacology and Toxicology, Friedrich Schiller University Jena, Germany
    Exp Toxicol Pathol 52:381-93. 2000
    ..cytotoxins led to necrosis and fatty degeneration of single or groups of hepatocytes within the intrasplenic transplants. This effect was most pronounced with CCl4 and TAA...
  90. ncbi Haemopoietic stem cell transplantation in Australia and New Zealand, 1992-2001: progress report from the Australasian Bone Marrow Transplant Recipient Registry
    I Nivison-Smith
    Australasian Bone Marrow Transplant Recipient Registry, NSW, Australian
    Intern Med J 35:18-27. 2005
    ..The Australasian Bone Marrow Transplant Recipient Registry (ABMTRR) has recorded transplant activity in Australia since 1992; transplant centres in New Zealand have corresponded with the Registry since 1998...
  91. ncbi Aprotinin decreases reperfusion injury and allograft dysfunction in clinical lung transplantation
    Hartmuth B Bittner
    Division of Thoracic and Cardiovascular Surgery, Heart Center Leipzig of the University of Leipzig, Struempell Strasse 39, 04289 Leipzig, Germany
    Eur J Cardiothorac Surg 29:210-5. 2006
    ..We hypothesized that the perioperative management with aprotinin decreases the incidence of allograft reperfusion injury and dysfunction after clinical lung transplantation...
  92. ncbi [Intraoperative oxygen consumption and organ function in liver transplantation]
    S Schwitalla
    Universitätsklinik für Anaesthesiologie und Intensivtherapie, Medizinischen Fakultat, Otto von Guericke Universitat Magdeburg
    Anaesthesiol Reanim 26:88-94. 2001
    ..Therefore, 51 liver transplants were investigated at the University Hospital of Magdeburg with regard to a correlation between intraoperative ..
  93. pmc A decade of experience with renal transplantation in African-Americans
    Clarence E Foster
    Division of Transplantation, Department of Surgery, School of Medicine, University of Maryland, Baltimore, Maryland 210201, USA
    Ann Surg 236:794-804; discussion 804-805. 2002
    ..METHODS From March 1990 to November 2001 the authors' center performed 2,167 renal transplants; 944 were in African-Americans (663 primary cadaver renal transplants and 253 primary Living donor renal ..
  94. ncbi Recurrent and de novo glomerular disease after renal transplantation: a report from Renal Allograft Disease Registry (RADR)
    S Hariharan
    Department of Nephrology, Medical College of Wisconsin, Milwaukee 53226, USA
    Transplantation 68:635-41. 1999
    ..A retrospective study was initiated through the Renal Allograft Disease Registry, to evaluate the prevalence and impact of recurrent and de novo diseases after transplantation...
  95. ncbi Haematopoietic stem cell transplantation in children in eastern European countries 1985-2004: development, recent activity and role of the EBMT/ESH Outreach Programme
    J Wachowiak
    Department of Paediatric Oncology, Hematology and Transplantology, University of Medical Sciences, Poznan, Poland
    Bone Marrow Transplant 41:S112-7. 2008
    ..Altogether, 2342 transplants were reported to the EBMT Registry during this time (Poland 953, Czech Republic 501, Hungary 269, Russia 217, ..
  96. ncbi The effects of cholinergic drugs and cholinergic-rich foetal neural transplants on alcohol-induced deficits in radial maze performance in rats
    H Hodges
    Department of Psychology MRC Brain, Behaviour and Psychiatry Research Group, London, U K
    Behav Brain Res 43:7-28. 1991
    ..b>Transplants into cortex and hippocampus of cholinergic-rich basal forebrain (BF) and ventral mesencephalon (VM) foetal ..
  97. ncbi HLA-identical sibling renal transplantation--a 21-yr single-center experience
    A M de Mattos
    Laboratory of Immunogenetics, Oregon Health Sciences University, Portland 97201, USA
    Clin Transplant 13:158-67. 1999
    ..Unlike cadaveric transplants, however, factors that affect long-term survival of these immunologically privileged grafts are not well ..
  98. ncbi Large antigenic skin load in total abdominal wall transplants permits chimerism induction
    Serdar Nasir
    Department of Plastic and Reconstructive Surgery, Cleveland Clinic, Cleveland, OH 44195, USA
    Ann Plast Surg 61:572-9. 2008
    The application of composite tissue allograft (CTA) transplants in clinical reconstruction is parallel with extended knowledge of anatomy, microsurgical skills and development of transplantation immunology...
  99. ncbi Transplants and neurotrophic factors increase regeneration and recovery of function after spinal cord injury
    Barbara S Bregman
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20007, USA
    Prog Brain Res 137:257-73. 2002
    Earlier studies suggested that while after spinal cord lesions and transplants at birth, the transplants serve both as a bridge and as a relay to restore supraspinal input caudal to the injury (Bregman, 1994), after injury in the adult ..
  100. ncbi A study of HLA-G polymorphism and linkage disequilibrium in renal transplant patients and their donors
    Alessandro Pirri
    Laboratory of Immunogenetics and Histocompatibility LIGH, Department of Genetics, Universidade Federal do Parana, Brazil
    Transpl Immunol 20:143-9. 2009
    ..HLA-A, HLA-B, HLA-DR and HLA-DQ compatibility are widely studied in clinical transplants but few studies investigated the influence of non-classical HLA loci, such as HLA-G, a non-classical class I ..
  101. pmc Lessons learned from more than 1,000 pancreas transplants at a single institution
    D E Sutherland
    Department of Surgery, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Ann Surg 233:463-501. 2001
    ..To determine outcome in diabetic pancreas transplant recipients according to risk factors and the surgical techniques and immunosuppressive protocols that evolved during a 33-year period at a single institution...

Research Grants78

  1. Sutureless Laparoscopic Partial Nephrectomy Using Laser Tissue Welding: Preclinic
    Yasmin Wadia; Fiscal Year: 2013
    ..include liver trauma repair and after resection for primary and metastatic liver tumors;split liver transplants doubling donor organ pool;partial nephrectomy for benign and malignant lesions;urethral repair: for hypospadias,..
  2. Mice Humanized with Hepatocytes and iPS Cells from Patients with Metabolic Diseas
    Stephen C Strom; Fiscal Year: 2010
    ..bile salt export pump (BSEP) results in severe cholestasis and fibrosis in human patients requiring whole organ transplants, yet the knockout mouse is nearly without a phenotype...
  3. Cardiotrophin-Like Cytokine 1, a Candidate Molecule for the FSGS Factor
    Virginia J Savin; Fiscal Year: 2010
    ..FSGS recurs in some patients with FSGS who have kidney failure and receive kidney transplants. The recurrence appears to be related to a small protein in the plasma that injures the glomeruli and leads to ..
  4. Physiological role of PRDM16 in brown fat development and energy balance
    Patrick Seale; Fiscal Year: 2011
    ..vascular (SV) cells from white fat promoted adipogenesis in vivo after subcutaneous transplantion, however the transplants were always small (1-2 mm), had the unilocular appearance of white adipose and did not express the thermogenic ..
  5. Non-viral Genetic Modification of Antigen-presenting Cells in Allografts
    Wilson S Meng; Fiscal Year: 2011
    ..S. Approximately 100,000 patients are currently waiting for compatible transplants. The current drugs used in controlling transplant rejection are non-specific, thereby subjecting patients to ..
  6. Immunomodulatory and regenerative effects of mesenchymal stem cells on allografts
    Norma S Kenyon; Fiscal Year: 2013
    ..phenotypic changes that occur in the peripheral blood and tissues of monkey recipients of islet or renal/MSC co-transplants to define biomarkers common to MSC efficacy/non-efficacy for both models, as well as markers unique to each ..
  7. Collagen X and heparan sulfate proteoglycan in the hematopoietic stem cell niche.
    ELIZABETH G SWEENEY; Fiscal Year: 2012
    ..To test this, 1) bone marrow transplants, co-cultures and cytokine analyses will confirm the altered marrow environment and identify the COJ resident ..
  8. Biology and Pathologies of Type V Collagen
    Daniel S Greenspan; Fiscal Year: 2013
    ..to obliterative bronchiolitis(OB), the fibroproliferative process responsible for rejection of >50% of lung transplants. An observation that 11(V) chains are specifically induced in atherosclerotic plaques prompted the principal ..
  9. TLR4 Inhibition to Reduce Cerebral Ischemia Reperfusion Injury
    LORI ANN HOLLE; Fiscal Year: 2011
    ..IRI is a detrimental feature of many clinical events such as organ transplants, cardiopulmonary bypass (CPB) used in cardiac surgery, myocardial infarction (MI), and stroke...
  10. Roles for microRNA-122 in hepatitis C virus RNA amplification
    Peter Sarnow; Fiscal Year: 2013
    ..of patients do not resolve the infection and become chronic carriers, ultimately needing expensive liver transplants. There is no vaccine for HCV, and current treatments, which include ribavirin and interferon 1, are expensive ..
  11. Pluripotent stem cell-derived HSCs: improvements and molecular mechanisms
    Patrick Cahan; Fiscal Year: 2013
    ..used to treat a variety of diseases currently treated (when possible) with allogeneic or autologous bone marrow transplants, especially hematological malignancies...
  12. Novel SCID rat models for human cell transplantation studies
    Joseph C Ruiz; Fiscal Year: 2010
    ..In the rat, such transplants would enable a wide variety of experimental manipulations that would not be possible in mice...
  13. Hematopoietic Stem Cells (HSCs) as Juvenile Protective Factors that Alter Aging
    David E Harrison; Fiscal Year: 2011
    ..Aim 4 tests whether transplants of intrinsic or extrinsic juvenile protective factors into aged mice will improve HSC function and increase ..
  14. Optical Molecular Tomography for Regenerative Medicine
    Ge Wang; Fiscal Year: 2013
    ..to devise new ways to repair or replace damaged tissues and organs for millions of patients who cannot receive transplants. A core technology is the bioengineering of a functional tissue or organ by seeding living cells onto a ..
  15. Testing the Therapeutic Potential of iPS Cells for Inherited Skin Diseases
    Jakub Tolar; Fiscal Year: 2013
    ..Tolar's initial clinical trials were very promising, there are safety concerns with allogeneic transplants, such as toxicity to chemotherapy required for conditioning before transplantation, and susceptibility to ..
  16. Structure and Function of the Hepatitis C Virus Genome
    Peter Sarnow; Fiscal Year: 2013
    ..of patients do not resolve the infection and become chronic carriers, ultimately needing expensive liver transplants. There is no vaccine for HCV, and current treatments, which include ribavirin and interferon 1, are expensive ..
  17. Nebraska/Kansas Blood and Marrow Transplant Research Network
    JULIE MARIE VOSE; Fiscal Year: 2013
    ..Physicians at KUMC have expertise in allogeneic stem cell transplantation, alternative donor transplants, and graft-versus-host disease...
  18. Non-viral gene therapy for sickle cell anemia
    CLIFFORD JOHN STEER; Fiscal Year: 2012
    ..human SCA patients and generate persistent erythroid-specific expression of the transgene for use in human mini-transplants and will improve the clinical phenotype in patients...
  19. Misregulation of receptor tyrosine kinase signaling in PKD
    Jordan A Kreidberg; Fiscal Year: 2013
    ..function and progression to end-stage renal disease, that can only be treated by lifelong dialysis or kidney transplants. As a disease that affects 1 in 800~1000 individuals, PKD is among the most common genetic disorders...
  20. Biliary Atresia, Cholestatic Liver Diseases, and Cystic Fibrosis: Indiana Univers
    Jean Pappas Molleston; Fiscal Year: 2013
    ..Biliary atresia accounts for more than half of pediatric liver transplants. Genetic causes of neonatal cholestasis include Alagille's syndrome, alpha-1-antitrypsin deficiency, ..
  21. Growth Factor and Antiapoptotic Gene Delivery to Human Islets
    Ram I Mahato; Fiscal Year: 2012
    ..Primary non-function is the main cause of islet graft failure and it results in the need for multi-donor transplants. Hepatocyte growth factor (HGF) increases 2-cell proliferation and promotes revascularization of islets, while ..
  22. Colorado Center for Childhood Liver Disease Research and Education
    Ronald J Sokol; Fiscal Year: 2013
    ..that occur in infants and children, leading to devastating morbidity and accounting for over 70% of liver transplants performed during childhood, posing a major public health burden...
  23. Nikkomycin Z treatment of early coccidioidal pneumonia: Phase II clinical trial
    DAVID LARWOOD; Fiscal Year: 2010
    ..Also at particular risk are immunosuppressed patients such as those with AIDS or recipients of organ transplants, pregnant women, the elderly and military personnel who train in the endemic desert regions...
  24. IL-22 in epithelial regeneration after allogeneic transplant
    Alan Hanash; Fiscal Year: 2013
    ..We will treat transplants recipients with systemic short-acting recombinant IL-22, induce constitutive IL-22 with an engineered ..
  25. Regulation of Innate Immunity by the Sympathetic Nervous System Druing Sepsis
    Eric J Seeley; Fiscal Year: 2013
    ..relevance of all of these cell culture findings will be tested in mouse models of infection using bone marrow transplants and transgenic mice...
  26. CTGF promotes beta cell proliferation &revascularization in islet transplants
    Uma Gunasekaran; Fiscal Year: 2011
    ....
  27. ROCK inhibitor suppression of GVHD with retention of GVL response
    Sujatha Iyengar; Fiscal Year: 2012
    ..Acute graft vs. host disease (GVHD) is a serious complication in more than a third of bone marrow transplants (BMTs) between MHC matched donors and recipients, and the proximate cause of death in ~ 15% of BMT patients...
  28. Differentiation of Cord Blood Mesenchymal Stem Cells to Corneal Endothelium
    Nancy C Joyce; Fiscal Year: 2010
    ..This corneal construct will be transplanted into a recipient mouse eye. The contralateral eye, corneal transplants containing cultured HCEC, and donor corneas with normal mouse endothelium will act as controls...
  29. Mechanisms of Sensitization in High Risk Corneal Grafts
    Reza Dana; Fiscal Year: 2013
    ..low-risk transplant immunity. We hypothesize that (i) induction of immunity to high- risk corneal transplants is characterized by a significantly enhanced capacity of alloantigen-bearing antigen- presenting cells (APC) to ..
  30. Depot calcineurin inhibitors to prevent graft rejection
    Thomas J Smith; Fiscal Year: 2010
    ..The PI led the team that developed two other FDA approved drug delivery systems. More than 50,000 transplants requiring immunosupression are performed annually in the largest 7 markets (US, Japan, Germany, Britain, Canada,..
  31. Regulation and Function of the HCMV pp71 Tegument Protein
    Julie Kerry; Fiscal Year: 2009
    ..in patients with a compromised immune system, including AIDS patients and recipients of organ and bone marrow transplants. In addition, HCMV can cross the placenta and infect the fetus resulting in a high incidence of birth defects ..
  32. Adipose Organ Transplant for Treatment of Maple Syrup Urine Disease
    CHRISTOPHER JOHN LYNCH; Fiscal Year: 2012
    ..donor livers outside of experimental studies, and at over a half million dollars, the first year costs of liver transplants challenge the practicality of this approach...
  33. The Role of Complement in Airway Microvascular Disease
    MARK ROBERT NICOLLS; Fiscal Year: 2013
    ..Summary/Abstract Microvascular loss may be an unappreciated root cause of chronic rejection for all solid organ transplants. As the only solid organ transplant that does not undergo primary systemic arterial revascularization at the ..
  34. FEASIBILITY OF REPAIRING GBM DEFECTS IN VIVO
    Jeffrey H Miner; Fiscal Year: 2012
    ..Although the positive effects of bone marrow and other cell transplants or infusions on progression of kidney disease seem promising, the reported effects of these procedures on the ..
  35. Tomotherapy and Hematopoietic Stem Cells For Tolerance to Kidney Transplants
    Samuel Strober; Fiscal Year: 2013
    ..We propose to test these hypotheses by means of 2 specific aims: 1) Combined Hematopoietic Cell/Kidney Transplants: to determine the proportion of Rhesus macaques that can be withdrawn from all immunosuppressive drugs while ..
  36. There Will Be Blood: Stem Cell Niche Driven Derivation of HSC from ES Cells
    PAUL JOHN SIMMONS; Fiscal Year: 2010
    ..HSC content will be quantitated by limitdilution and serial transplants. The strength of this proposal lies in the consortium of investigators who collectively bring considerable ..
  37. Manipulation of Host Angiogenesis as a Therapeutic Strategy against Invasive Pulm
    Dimitrios P Kontoyiannis; Fiscal Year: 2010
    ..patients, and the most common cause of infectious pneumonic mortality in recipients of hematopoietic stem cell transplants. Mortality from IA remains unacceptably high despite the availability of novel antifungal agents...
  38. Mechanism of murine coronavirus induced hepatitis
    Susan R Weiss; Fiscal Year: 2010
    ..The necessity for liver transplants as a result of HCV and HBV infection has become a serious public health issue;however, broadly effective ..
  39. A search for genes that regulate allogeneic stem cell competition
    Irving L Weissman; Fiscal Year: 2013
    ..Graft rejection in immune competent vertebrates can utilize both T and NK cell responses to hematopoietic cell transplants [HCT] and tissue grafts...
  40. Genome Sequencer FLX Instrument
    ANNE VIRGINIA KANE; Fiscal Year: 2010
    ..children with pneumonia or cystic fibrosis or infected with Cryptosporidium, recipients of bone marrow transplants, patients colonized with antibiotic resistant bacteria, carriers of Shiga-toxin producing E...
  41. Chronic kidney disease in survivors of hematopoietic cell transplant
    Sangeeta Hingorani; Fiscal Year: 2012
    ..Ten thousand of these transplants are performed in the United States...
  42. Endothelial microparticles in patients with kidney transplants
    Sergey Brodsky; Fiscal Year: 2012
    ..Recent studies have indicated changes in circulating EMP levels in patients with solid organ transplants, including kidneys...
  43. Chronic Toll-like Receptor Ligation and Hematopoietic Stem Cell Aging
    Brandt L Esplin; Fiscal Year: 2010
    ..Novel application of F1 hybrid recipients will also allow precise quantification of HSC fitness during serial transplants. Well-defined culture systems will further assess HSC differentiation potential...
  44. Homing Receptor Determinants of HSC
    Irving L Weissman; Fiscal Year: 2013
    ..It is because of this property that bone marrow or hematopoietic cell transplants successfully rescue patients from otherwise lethal damage to their blood system such as that experienced by ..
  45. Chronic imaging of cellular dynamics after cortical microhemorrhage
    Chris B Schaffer; Fiscal Year: 2013
    ..These experiments use chimeric animals created through bone marrow transplants to achieve specific labeling of either microglia or macrophages...
  46. HEMOPROTEIN OXIDATION AND HEME CATABOLISM
    Paul R Ortiz de Montellano; Fiscal Year: 2013
    ..CO and biliverdin provide strong protection against inflammation, organ rejection in heart, kidney, and liver transplants, and neurological and cardiovascular disorders...
  47. Intravascular Cardiac Assist System for Decompression and Recovery
    CAITLYN J BOSECKER; Fiscal Year: 2010
    ..benefit, but its impact is limited by the number of donor organs available;worldwide, less than 2900 heart transplants occurred in 2005...
  48. Immunosuppression by Adult Stem Cells
    Yufang Shi; Fiscal Year: 2013
    ..In vivo, MSCs prevented the rejection of allogeneic skin transplants, suppressed antigen-specific DTH responses, and inhibited graft-versus-host disease (GvHD) in mice...
  49. Mechanisms of oval cell activation and differentiation
    Bryon E Petersen; Fiscal Year: 2013
    ..This knowledge will help to guide the development of strategies for the therapeutic use of stem cell transplants for the treatment of liver disease.
  50. MECHANISMS OF ALLOGENEIC STEM CELL EDUCATION IN SCID
    Rebecca H Buckley; Fiscal Year: 2010
    ..To approach this question, we plan to measure telomere length in the T cells of the various molecular types of transplants, 3) reducing the incidence of autoimmunity, and 4) contributing to their overall successful immune ..
  51. High Efficiency Microfluidic Purification of Stem Cells to Improve Transplants
    James C Sturm; Fiscal Year: 2012
    ..removal from transplant grafts increases the risk of harmful side effects in hematopoietic stem cell transplants, while poor recovery of viable leukocytes and CD34+ cells reduces engraftment success and limits the treatable ..
  52. iPS-derived hepatocytes as a model of familial hypercholesterolemia
    Max A Cayo; Fiscal Year: 2013
    ..followed by differentiation and rescue of phenotype, paving the way for possible creation of patient-specific transplants, and 2) whether iPS-derived hepatocytes can serve as a model for testing and refining the efficacy of the ..
  53. Acute Humoral Rejection of Renal Allografts
    Robert L Fairchild; Fiscal Year: 2013
    ..The use of current immunosuppression has decreased the incidence of T lymphocyte mediated rejection of renal transplants but rejection mediated by antibodies that bind to the graft continues to be a problem in causing graft loss...
  54. Membrane-associated PDE3-binding proteins in human myocardium
    Matthew A Movsesian; Fiscal Year: 2013
    ..Advanced therapeutic options such as heart transplants and left-ventricular assist devices are often unfeasible, especially in aging veterans, because of ..
  55. TH17 Autoimmunity to Type V Collagen in Heart and Lung Transplant
    David S Wilkes; Fiscal Year: 2013
    ..extracellular matrix (ECM) and the process of chronic rejection, known as obliterative bronchiolitis in lung transplants recipients...
  56. Role of innate immunity and injury in transplant-induced reactivation of MCMV
    Michael M Abecassis; Fiscal Year: 2013
    ..by applicant): Reactivation of latent CMV is frequently observed in recipients of solid organ and bone marrow transplants and is a significant cause of morbidity and mortality in immunocompromised hosts...
  57. Role of PGE2 and other eicosanoids in hematopoietic stem cell function
    Louis M Pelus; Fiscal Year: 2013
    ..source of HSC;however the total number of stem cells that can be obtained is usually too small for adult transplants. In this proposal we will investigate the mechanisms by which eicosanoids enhance HSC function and facilitate ..
  58. Angiogenesis and Long-term Bone and Joint Allotransplant Survival
    Allen T Bishop; Fiscal Year: 2012
    ..and #4) to evaluate the viability, healing potential and function of orthotopic whole joint composite tissue transplants in a larger animal (rabbit knee) model...
  59. Cytokine Modulation of Heme Oxygenase-1 in Chronic Kidney Transplant Rejection
    Anupam Agarwal; Fiscal Year: 2010
    ..Lay Summary: Loss of kidney transplants due to progressive narrowing of blood vessels in the kidney is a significant clinical problem...
  60. Phase 2 Study of Abatacept with Calcineurin Inhibition and Methotrexate for GVHD
    Leslie S Kean; Fiscal Year: 2013
    ..result in a high rate of transplant-related mortality, with approximately 30% of recipients of unrelated donor transplants dying of transplant-related complications...
  61. Processing and Preservation of Human Umbilical Cord Stem Cells for Cell Therapeut
    Alfred Bahnson; Fiscal Year: 2010
    ..for donors, 3) reduced likelihood of transmitting infections and 4) ability to store fully tested and HLA-typed transplants (1)...
  62. T Cell-Mediated Mechanisms of Autoimmunity in Murine and Human Biliary Atresia
    CARA LYNN MACK; Fiscal Year: 2011
    ..the resulting need for liver transplantation in 80% of patients, accounting for half of all pediatric liver transplants. Current therapy for BA is inadequate because the etiology and pathogenesis of BA is not understood, however ..
  63. EMBRYONIC DOPAMINE CELL IMPLANTS FOR PARKINSONISM
    Curt Freed; Fiscal Year: 2005
    ..of years? 2) Does fluorodopa uptake on PET scans increase progressively? Correlate with clinical change? 3) Do transplants in the open trial have the same clinical course as those in the blind trial? 4) Do transplant effects plateau ..
  64. Novel Molecular and Cellular Therapies in Fanconi Anemia
    David Williams; Fiscal Year: 2009
    ..transfusions, the use of androgens to stimulate hematopoiesis in vivo, and the use of HLA-identical sibling transplants (available to a minority of patients) has extended the life- expectancy of FA patients, however...
  65. Development of ex vivo Expanded Megakaryocyte Progenitors for Platelet Recovery F
    Holger Karsunky; Fiscal Year: 2009
    ..In human autologous peripheral blood stem cell transplants it has been noted that platelet recovery correlates with the number of CD34+CD41+ MKP...
  66. Open-Source Informatics Used to Improve Outcomes in Pediatric Liver Transplants
    STEVEN PETER BUCUVALAS; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: The 500 children per year who benefit from pediatric liver transplants (PLTs) provided by the approximately 40 North American PLT centers represent just one of the many groups of ..
  67. Development of a National Incompatible Kidney Transplant Registry
    Robert A Montgomery; Fiscal Year: 2010
    ..IKT is an emerging practice in which patients can receive kidney transplants across antibody barriers through the use of various desensitization techniques...
  68. Bronchoalveolar Lavage Cell Biomarkers in Lung Rejection
    Marshall I Hertz; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Lung transplants have been performed in over 20,000 individuals with advanced lung disease, with two-year survival of 70% and dramatic improvements in quality of life...
  69. PHARMACOLOGY OF FETAL STRIATAL TISSUE TRANSPLANTS
    Andrew Norman; Fiscal Year: 1992
    ..animal models of neurodegenerative disorders have demonstrated the exciting possibility of using fetal tissue transplants to reverse the deficits induced by the neurodegenerative process...
  70. IMMUNOGENETICS OF MARROW ALLOGRAFTING
    John Hansen; Fiscal Year: 1992
    Allogeneic marrow transplants from HLA genotypically identical siblings have become life-saving therapy for patients with various congenital and acquired diseases of the immune and hematopoietic systems...
  71. GENE THERAPY FOR SPINAL CORD REGENERATION
    George Smith; Fiscal Year: 2006
    ..These axons regenerate into and throughout these transplants, but fail to grow significant distances back into the adult central nervous system (CNS)...
  72. SUPPLY, EVALUATION AND SELECTION OF LIVING RENAL DONORS
    Akinlolu Ojo; Fiscal Year: 2001
    ..living renal donation is accepted as a low risk procedure with superior allograft survival, only 25% of transplants performed in European Americans and 10% of transplants in African americans are from living donors...
  73. Syrian Hamster as a Permissive Model for Testing Anti-Adenovirus Drugs
    William Wold; Fiscal Year: 2007
    ..are a significant problem in immunosuppressed humans, especially in children undergoing allogeneic stem cell transplants. About 20% of these pediatric patients develop disseminated Ad infections and about half of the patients die...
  74. Device for Facilitating Corneal Transplantation
    YICHIEH SHIUEY; Fiscal Year: 2006
    ..Approximately 100,000 corneal transplants are performed worldwide annually for the treatment of corneal visual loss...
  75. Improved recombinant collagenase for tissue dissociation
    Robert McCarthy; Fiscal Year: 2007
    ..The number of islet transplants performed over the last 6 years (~550) since publication of the Edmonton Protocol now exceeds the number of ..
  76. IMPACT OF STANDARDIZATION AND PROCEDURE OPTIMIZATION ON*
    Ahmed Gaber; Fiscal Year: 2005
    ..presentation, and isolation with the aim of optimizing these steps to achieve uniform success with single donor transplants. Our team of clinicians and islet researchers has a long history of experience in the treatment of diabetes by ..
  77. CORD BLOOD COLLECTION DEVICE
    RICHARD MEYST; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Although 30,000 bone marrow transplants occur each year in attempts to cure diseases such as leukemia, thalassemia and sickle cell disease, approximately 60,000 patients eligible for transplant die ..
  78. NAPRTCS CLINICAL TRIALS IN PRIMARY & REPEAT TRANSPLANTS
    William Harmon; Fiscal Year: 2002
    ..Project II is entitled "Pilot study of anti-CD40L mAb in repeat cadaver donor transplants," and has two specific aims...