Summary: Any device or element which converts an input signal into an output signal of a different form. Examples include the microphone, phonographic pickup, loudspeaker, barometer, photoelectric cell, automobile horn, doorbell, and underwater sound transducer. (McGraw Hill Dictionary of Scientific and Technical Terms, 4th ed)

Top Publications

  1. ncbi Design of efficient, broadband single-element (20-80 MHz) ultrasonic transducers for medical imaging applications
    Jonathan M Cannata
    NIH Resource on Medical Ultrasonic Transducer Technology, Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 50:1548-57. 2003
  2. ncbi Implementation of a real-time human movement classifier using a triaxial accelerometer for ambulatory monitoring
    Dean M Karantonis
    Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia
    IEEE Trans Inf Technol Biomed 10:156-67. 2006
  3. pmc A method based on multi-sensor data fusion for fault detection of planetary gearboxes
    Yaguo Lei
    State Key Laboratory for Manufacturing Systems Engineering, Xi an Jiaotong University, No 28 Xianning West Road, Xi an 710049, China
    Sensors (Basel) 12:2005-17. 2012
  4. pmc Underwater Wireless Sensor Networks: how do acoustic propagation models impact the performance of higher-level protocols?
    Jesús Llor
    Physics and Computer Engineering Department, Miguel Hernandez University, Ave Universidad s n, Ed Alcudia, 03202 Elche, Alicante, Spain
    Sensors (Basel) 12:1312-35. 2012
  5. ncbi Refractive index sensing based on higher-order mode reflection of a microfiber Bragg grating
    Yu Zhang
    Wuhan National Laboratory for Optoelectronics and Institute of Optoelectronics Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China
    Opt Express 18:26345-50. 2010
  6. pmc Improving planetary rover attitude estimation via MEMS sensor characterization
    Javier Hidalgo
    Centro de Automática y Robótica, UPM CSIC, Jose Gutierrez Abascal 2, Madrid 28006, Spain
    Sensors (Basel) 12:2219-35. 2012
  7. ncbi Graphene-on-paper sound source devices
    He Tian
    Institute of Microelectronics, Tsinghua University, Beijing 100084, China
    ACS Nano 5:4878-85. 2011
  8. ncbi Thermo-optic control of dielectric-loaded plasmonic waveguide components
    Jacek Gosciniak
    Institute of Sensors, Signals and Electrotechnics SENSE, University of Southern Denmark, Niels Bohrs Alle 1, Odense M, Denmark
    Opt Express 18:1207-16. 2010
  9. ncbi Gait posture estimation using wearable acceleration and gyro sensors
    Ryo Takeda
    Division of Human Mechanical Systems and Design, Graduate School of Engineering, Hokkaido University, N13 W8, Kita ku, Sapporo 060 8628, Japan
    J Biomech 42:2486-94. 2009
  10. pmc Focused ultrasound modulates region-specific brain activity
    Seung Schik Yoo
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuroimage 56:1267-75. 2011

Detail Information

Publications333 found, 100 shown here

  1. ncbi Design of efficient, broadband single-element (20-80 MHz) ultrasonic transducers for medical imaging applications
    Jonathan M Cannata
    NIH Resource on Medical Ultrasonic Transducer Technology, Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 50:1548-57. 2003
    ..the design, fabrication, and testing of sensitive broadband lithium niobate (LiNbO3) single-element ultrasonic transducers in the 20-80 MHz frequency range. Transducers of varying dimensions were built for an f# range of 2.0-3.1...
  2. ncbi Implementation of a real-time human movement classifier using a triaxial accelerometer for ambulatory monitoring
    Dean M Karantonis
    Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia
    IEEE Trans Inf Technol Biomed 10:156-67. 2006
    ..3% accuracy), and detection of possible falls was made with 95.6% accuracy. Results demonstrate the feasibility of implementing an accelerometry-based, real-time movement classifier using embedded intelligence...
  3. pmc A method based on multi-sensor data fusion for fault detection of planetary gearboxes
    Yaguo Lei
    State Key Laboratory for Manufacturing Systems Engineering, Xi an Jiaotong University, No 28 Xianning West Road, Xi an 710049, China
    Sensors (Basel) 12:2005-17. 2012
    ..The comparisons between the proposed method and the methods based on individual sensors show that the former achieves much higher accuracies in detecting planetary gearbox faults...
  4. pmc Underwater Wireless Sensor Networks: how do acoustic propagation models impact the performance of higher-level protocols?
    Jesús Llor
    Physics and Computer Engineering Department, Miguel Hernandez University, Ave Universidad s n, Ed Alcudia, 03202 Elche, Alicante, Spain
    Sensors (Basel) 12:1312-35. 2012
  5. ncbi Refractive index sensing based on higher-order mode reflection of a microfiber Bragg grating
    Yu Zhang
    Wuhan National Laboratory for Optoelectronics and Institute of Optoelectronics Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China
    Opt Express 18:26345-50. 2010
    ..The measured maximum sensitivity is ~102 nm/RIU (RI unit) at an RI value of 1.378 in an MFBG with a diameter of 6 μm...
  6. pmc Improving planetary rover attitude estimation via MEMS sensor characterization
    Javier Hidalgo
    Centro de Automática y Robótica, UPM CSIC, Jose Gutierrez Abascal 2, Madrid 28006, Spain
    Sensors (Basel) 12:2219-35. 2012
    ..The strength of the approach has been verified with representative tests of novel high-grade MEMS inertia sensors and exemplary planetary rover platforms with promising results...
  7. ncbi Graphene-on-paper sound source devices
    He Tian
    Institute of Microelectronics, Tsinghua University, Beijing 100084, China
    ACS Nano 5:4878-85. 2011
    ..It could open wide applications in multimedia, consumer electronics, biological, medical, and many other areas...
  8. ncbi Thermo-optic control of dielectric-loaded plasmonic waveguide components
    Jacek Gosciniak
    Institute of Sensors, Signals and Electrotechnics SENSE, University of Southern Denmark, Niels Bohrs Alle 1, Odense M, Denmark
    Opt Express 18:1207-16. 2010
    ..Strong output modulation (> 20%) is demonstrated with MZI- and WRR-based components, and efficient (approximately 30%) rerouting is achieved with DC switches...
  9. ncbi Gait posture estimation using wearable acceleration and gyro sensors
    Ryo Takeda
    Division of Human Mechanical Systems and Design, Graduate School of Engineering, Hokkaido University, N13 W8, Kita ku, Sapporo 060 8628, Japan
    J Biomech 42:2486-94. 2009
    ..A moving stick figure model of each volunteer was created to visually confirm the walking posture. Further, the knee and ankle joint trajectories in the horizontal plane showed that the left and right legs were bilaterally symmetric...
  10. pmc Focused ultrasound modulates region-specific brain activity
    Seung Schik Yoo
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuroimage 56:1267-75. 2011
    ..It is anticipated that the use of this technology will have an impact on brain research and may offer novel therapeutic interventions in various neurological conditions and psychiatric disorders...
  11. ncbi Gait assessment in Parkinson's disease: toward an ambulatory system for long-term monitoring
    Arash Salarian
    Laboratory of Movement Analysis and Measurement LMAM, Swiss Federal Institute of Technology EPFL, Lausanne, Switzerland
    IEEE Trans Biomed Eng 51:1434-43. 2004
    ..We concluded that our method provides a simple yet effective way of ambulatory gait analysis in PD patients with results confirming those obtained from much more complex and expensive methods used in gait labs...
  12. ncbi A threshold-based fall-detection algorithm using a bi-axial gyroscope sensor
    A K Bourke
    Biomedical Electronics Laboratory, Department of Electronic and Computer Engineering, University of Limerick, Limerick, Ireland
    Med Eng Phys 30:84-90. 2008
    ..59 rad (Fall Threshold 3), a fall is detected. Results show that falls can be distinguished from ADL with 100% accuracy, for a total data set of 480 movements...
  13. ncbi Supported microfiber loops for optical sensing
    Xin Guo
    Department of Optical Engineering, State Key Laboratory of Modern Optical Instrumentation, Zhejiang University, Hangzhou 310027, China
    Opt Express 16:14429-34. 2008
    ..8 x 10(-5)...
  14. pmc Bias observed in time-of-flight shear wave speed measurements using radiation force of a focused ultrasound beam
    Heng Zhao
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Ultrasound Med Biol 37:1884-92. 2011
    ..The possible causes of the bias and options for correction are discussed. These bias errors must be taken into account to provide accurate and precise time-of-flight shear wave speed measurements for clinical use...
  15. ncbi Characterization of QCM sensor surfaces coated with molecularly imprinted nanoparticles
    Kristina Reimhult
    The IMEGO Institute, Arvid Hedvalls Backe 4, SE 411 33 Göteborg, Sweden
    Biosens Bioelectron 23:1908-14. 2008
    ..Various approaches have been adopted to interface MIPs with different transducers, including the use of pre-made imprinted particles and the in situ preparation of thin polymer layers directly ..
  16. ncbi Comparison of lung sound transducers using a bioacoustic transducer testing system
    Steve S Kraman
    Department of Internal Medicine, Univ of Kentucky, Kentucky Clinic L 547, Lexington, KY 40536, USA
    J Appl Physiol (1985) 101:469-76. 2006
    ..We conclude that there are important differences among commonly used lung sound sensors that have to be defined to allow the comparison of data from different laboratories...
  17. pmc Optimal methods of RTK-GPS/accelerometer integration to monitor the displacement of structures
    Jinsang Hwang
    Department of Civil, Architectural and Environmental Engineering, Sungkyunkwan University, Suwon 440 746, Korea
    Sensors (Basel) 12:1014-34. 2012
    ..The integration method that uses frequency-based displacement extraction was most appropriate for the integrated RTK-GPS/accelerometer method of comprehensively measuring the dynamic, static, and quasi-static displacements...
  18. pmc Enhanced responsivity of photodetectors realized via impact ionization
    Ji Yu
    State Key Laboratory of Luminescence and Applications, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033, China
    Sensors (Basel) 12:1280-7. 2012
    ..The results reported in this paper provide a general route to enhance the responsivity of a photodetector, thus may represent a step towards high-performance photodetectors...
  19. ncbi Factors improving the vibration transfer of the floating mass transducer at the round window
    Andreas Arnold
    University Department of ENT, Head and Neck Surgery, Inselspital, University of Bern, Bern, Switzerland
    Otol Neurotol 31:122-8. 2010
    ..The aim of the present experimental study is to examine the influence of different ways of FMT placement at the round window on the vibration energy transfer to the cochlea...
  20. pmc Normal and shear strain estimation using beam steering on linear-array transducers
    M Rao
    Department of Medical Physics, The University of Wisconsin Madison, Madison, WI 53706, USA
    Ultrasound Med Biol 33:57-66. 2007
    ..However, more work is required for the selection of an appropriate value for the maximum beam angle for optimal performance of this technique...
  21. ncbi Demonstration of second-harmonic IVUS feasibility with focused broadband miniature transducers
    Chaitanya Chandrana
    Department of Biomedical Engineering, Cleveland, OH, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 57:1077-85. 2010
    Focused broadband miniature polyvinylidene fluoride-trifluoroethylene (PVDF TrFE) ultrasonic transducers were investigated for intravascular (IVUS) second-harmonic imaging...
  22. pmc Performance study of the application of Artificial Neural Networks to the completion and prediction of data retrieved by underwater sensors
    Carlos Baladrón
    Universidad de Valladolid, Dpto TSyCeIT, ETSIT, Paseo de Belén 15, 47011 Valladolid, Spain
    Sensors (Basel) 12:1468-81. 2012
  23. ncbi A gradient microarray electronic nose based on percolating SnO(2) nanowire sensing elements
    Victor V Sysoev
    Department of Physics, Saratov State Technical University, Saratov 410054, Russia
    Nano Lett 7:3182-8. 2007
    ..It has been found that, in addition to the temperature gradient across the nanowire layer, the density and morphological inhomogeneities of nanowire mats define the discriminating power of the electronic nose...
  24. ncbi PMN-PT single crystal, high-frequency ultrasonic needle transducers for pulsed-wave Doppler application
    Qifa Zhou
    NIH Resource on Medical Ultrasonic Transducer Technology, Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 54:668-75. 2007
    High-frequency needle ultrasound transducers with an aperture size of 0.4 mm were fabricated using lead magnesium niobate-lead titanate (PMN-33% PT) as the active piezoelectric material...
  25. pmc Evaluation of round window stimulation using the floating mass transducer by intracochlear sound pressure measurements in human temporal bones
    Hideko Heidi Nakajima
    Department of Otology and Laryngology, Harvard Medical School, Cambridge, Massachusetts, U S A
    Otol Neurotol 31:506-11. 2010
    ..Round window (RW) stimulation with a floating mass transducer (FMT) can be studied experimentally and optimized to enhance auditory transduction...
  26. ncbi The reliability of using accelerometer and gyroscope for gait event identification on persons with dropped foot
    Hongyin Lau
    Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong SAR, China
    Gait Posture 27:248-57. 2008
    ..It was shown that the threshold detection method is reliable. Portable gait-monitoring devices can be used for monitoring of daily activities and functional control...
  27. pmc Secure cooperation of autonomous mobile sensors using an underwater acoustic network
    Andrea Caiti
    Department of Energy and Systems Engineering, Inter University Center on Integrated System for Marine Environment, University of Pisa, Largo L Lazzarino, 1, Pisa 56126, Italy
    Sensors (Basel) 12:1967-89. 2012
  28. ncbi The resonance frequencies and mode shapes of dental implants: Rigid body behaviour versus bending behaviour. A numerical approach
    V Pattijn
    K U Leuven, Faculty of Engineering, Division of Biomechanics and Engineering Design, Celestijnenlaan 200A, B 3001 Leuven, Belgium
    J Biomech 39:939-47. 2006
    ..In conclusion, it seems that the Osstell transducer is suited for the follow-up in time of the stability of an implant, but not for the quantitative comparison of the stability of implants...
  29. ncbi Metal and metal oxide nanoparticles in chemiresistors: does the nanoscale matter?
    Marion E Franke
    RWTH Aachen, Institut fur Anorganische Chemie, Landoltweg 1, 52054 Aachen, Germany
    Small 2:36-50. 2006
    ..This Review highlights the recent developments and reflects the impact of nanoscience on sensor technology...
  30. pmc A multi-fault diagnosis method for sensor systems based on principle component analysis
    Daqi Zhu
    Laboratory of Underwater Vehicles and Intelligent Systems, Shanghai Maritime University, Shanghai, 200135, China
    Sensors (Basel) 10:241-53. 2010
    ..Finally, the feasibility and effectiveness of the proposed method is demonstrated by simulation and comparison studies, in which two sensors in the system are out of order at the same time...
  31. ncbi Evaluation of instrumented shoes for ambulatory assessment of ground reaction forces
    Christian Liedtke
    Biomedical Signals and Systems, University of Twente, Faculty of Electrical Engineering, Mathematics and Computer Science, Institute for Biomedical Technology BMTI, P O Box 217, 7500 AE Enschede, The Netherlands
    Gait Posture 26:39-47. 2007
    ..In this study, shoes instrumented with two force transducers measuring forces and moments in three dimensions were evaluated...
  32. ncbi Introduction to the special section on M-Health: beyond seamless mobility and global wireless health-care connectivity
    Robert Istepanian
    IEEE Trans Inf Technol Biomed 8:405-14. 2004
  33. ncbi Gait event detection using linear accelerometers or angular velocity transducers in able-bodied and spinal-cord injured individuals
    Jan M Jasiewicz
    School of Human Movement Studies, Centre for Health Research, Queensland University of Technology, Kelvin Grove, Queensland 4059, Australia
    Gait Posture 24:502-9. 2006
    ..of gait event detection (toe-off and heel strike) using miniature linear accelerometers and angular velocity transducers in comparison to using standard pressure-sensitive foot switches...
  34. ncbi A description of an accelerometer-based mobility monitoring technique
    G M Lyons
    Biomedical Electronics Laboratory, Department of Electronic and Computer Engineering, University of Limerick, Limerick, Ireland
    Med Eng Phys 27:497-504. 2005
  35. pmc Design and implementation of an omni-directional underwater acoustic micro-modem based on a low-power micro-controller unit
    Tae Hee Won
    Digital Communications Laboratory, Electronic Engineering, Gangneung Wonju National University, Gangneung, Gangwon 201 702, Korea
    Sensors (Basel) 12:2309-23. 2012
    ..Since the modem satisfies the requirements for use in UWSNs, it could be deployed in a wide range of applications requiring underwater acoustic communication...
  36. ncbi Ultra-sensitive NEMS-based cantilevers for sensing, scanned probe and very high-frequency applications
    Mo Li
    Kavli Nanoscience Institute, California Institute of Technology, MS 114 36, Pasadena, California 91125, USA
    Nat Nanotechnol 2:114-20. 2007
    ..These devices use integrated electronic displacement transducers based on piezoresistive thin metal films, permitting straightforward and optimal nanodevice readout...
  37. pmc Drug-loaded nano/microbubbles for combining ultrasonography and targeted chemotherapy
    Zhonggao Gao
    Department of Bioengineering, University of Utah, Salt Lake City, UT 84112, USA
    Ultrasonics 48:260-70. 2008
    ..This effect is tumor-selective; no accumulation of echogenic microbubbles is observed in other organs. Effective chemotherapy of the MDA MB231 breast cancer tumors has been achieved using this technique...
  38. ncbi Treatment of mixed hearing losses via implantation of a vibratory transducer on the round window
    Vittorio Colletti
    ENT Department, University of Verona, Verona, Italy
    Int J Audiol 45:600-8. 2006
    ..These results suggest that round window implantation may offer a viable treatment option for individuals with severe mixed hearing losses who have undergone unsuccessful ossiculoplasties...
  39. pmc Realtime photoacoustic microscopy in vivo with a 30-MHz ultrasound array transducer
    Roger J Zemp
    Washington University, Optical Imaging Laboratory, Department of Biomedical Engineering, Saint Louis, Missouri 63130, USA
    Opt Express 16:7915-28. 2008
    ..Realtime imaging performance is demonstrated on phantoms and in vivo with absorbing structures identified to depths of 2.5-3 mm. This work represents the first high-frequency realtime photoacoustic imaging system to our knowledge...
  40. ncbi Long-term unrestrained measurement of stride length and walking velocity utilizing a piezoelectric gyroscope
    S Miyazaki
    Institute for Medical and Dental Engineering, Tokyo Medical and Dental University, Japan
    IEEE Trans Biomed Eng 44:753-9. 1997
    ..The accuracy of the device was evaluated in 20 normal subjects, seven above-the-knee (A/K) amputees, and ten hemiplegic patients, and relative accuracy within +/-15% was obtained, except for two special cases...
  41. pmc Label-free cancer cell detection with impedimetric transducers
    Roberto de la Rica
    Department of Chemistry and Biochemistry, Hunter College CUNY, 695 Park Ave, New York, New York 10065, USA
    Anal Chem 81:10167-71. 2009
  42. ncbi Super harmonic imaging: a new imaging technique for improved contrast detection
    Ayache Bouakaz
    Experimental Echocardiography, Erasmus University, Rotterdam, The Netherlands
    Ultrasound Med Biol 28:59-68. 2002
    ..Currently, due to the limited bandwidth of the transducers, only the second harmonic is selectively imaged, resulting in images with a superior quality to fundamental ..
  43. ncbi Development of a highly sensitive compact sized optical fiber current sensor
    Pramod R Watekar
    Graduate Program of Photon Science and Applied Physics Gwangju Institute of Science and Technology, 1 Oryong dong, Buk Gu, Gwangju 500 712, South Korea
    Opt Express 18:17096-105. 2010
    ..The modified sensitivity of this sensor was about 675 microrad/(Turn.A.m) for the loop radius of just 10 mm, which is more than 16 times larger than that of the single mode optical fiber current sensor...
  44. ncbi Lithium niobate transducers for MRI-guided ultrasonic microsurgery
    Spiros Kotopoulis
    Department of Engineering, The University of Hull, Kingston upon Hull, UK
    IEEE Trans Ultrason Ferroelectr Freq Control 58:1570-6. 2011
    ..In this paper, we explain the methodology we have used to build high-frequency high-intensity transducers using Y-36°-cut lithium niobate...
  45. ncbi Fabrication of high-frequency pMUT arrays on silicon substrates
    Thomas Pedersen
    Department of Micro and Nanotechnology, Technical University of Denmark, Kgs Lyngby, Denmark
    IEEE Trans Ultrason Ferroelectr Freq Control 57:1470-7. 2010
    ..micromachining for fabrication of linear arrays of high-frequency piezoelectric micromachined ultrasound transducers (pMUT) is presented...
  46. ncbi Theory and operation of 2-D array piezoelectric micromachined ultrasound transducers
    David E Dausch
    RTI International, Center for Materials and Electronic Technologies, Research Triangle Park, NC, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 55:2484-92. 2008
    Piezoelectric micromachined ultrasound transducers (pMUTs) are a new approach for the construction of 2-D arrays for forward-looking 3-D intravascular (IVUS) and intracardiac (ICE) imaging...
  47. ncbi Macrobending single-mode fiber-based refractometer
    Pengfei Wang
    Photonics Research Center, School of Electronic and Communications Engineering, Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland
    Appl Opt 48:6044-9. 2009
    ..75x10(-5) for a refractive index range from 1.4586 to 1.5396 at the wavelength of 1550 nm...
  48. ncbi Development of dual PZT transducers for reference-free crack detection in thin plate structures
    Hoon Sohn
    Department of Civil and Environmental Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea
    IEEE Trans Ultrason Ferroelectr Freq Control 57:229-40. 2010
    ..previously developed a reference-free NDT technique using 2 pairs of collocated lead zirconate titanate (PZT) transducers placed on both sides of a plate...
  49. pmc Localization algorithms of Underwater Wireless Sensor Networks: a survey
    Guangjie Han
    Department of Information and Communication Systems, Hohai University, 200 North Jinling Road, Changzhou 213022, China
    Sensors (Basel) 12:2026-61. 2012
    ..Moreover, we compare the localization algorithms in detail and analyze future research directions of localization algorithms in UWSNs...
  50. pmc Multivariate thermo-hygrometric characterisation of the archaeological site of Plaza de l'Almoina (Valencia, Spain) for preventive conservation
    Angel Fernández-Navajas
    Departamento de Física Aplicada U D Industriales, Universitat Politècnica de València, Valencia 46022, Spain
    Sensors (Basel) 13:9729-46. 2013
    ..Multivariate statistical analyses enabled us to characterise the microclimate of the archaeological site, allowing future testing to determine whether the conservation conditions have been altered. ..
  51. ncbi Acoustic impact localization in plates: properties and stability to temperature variation
    Guillemette Ribay
    Laboratoire Ondes et Acoustique, ESPCI, Paris, France
    IEEE Trans Ultrason Ferroelectr Freq Control 54:378-85. 2007
    ..A simple algorithm is shown to perfectly compensate for temperature impacts, which demonstrates the feasibility of the technique for outdoor time reversal interactive experiments...
  52. pmc Use of a real-time remote monitoring network (RTRM) to characterize the Guadalquivir estuary (Spain)
    Gabriel Navarro
    Departamento de Ecología y Gestión Costera, Instituto de Ciencias Marinas de Andalucia, ICMAN CSIC, Puerto Real, 11519, Cadiz, Spain
    Sensors (Basel) 12:1398-421. 2012
    ..The network installed provided accurate data that can be rapidly used for research or educational applications and by policy-makers or agencies in charge of the management of the coastal area...
  53. ncbi Design, fabrication, and evaluation of high frequency, single-element transducers incorporating different materials
    Kevin A Snook
    NIH Resource on Medical Ultrasonic Transducer Technology, Department of Bioengineering, The Pennsylvania State University, University Park 16802, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 49:169-76. 2002
    The performance of high frequency, single-element transducers depends greatly on the mechanical and electrical properties of the piezoelectric materials used...
  54. ncbi Imaging of implant needles for real-time HDR-brachytherapy prostate treatment using biplane ultrasound transducers
    Frank Andre Siebert
    Clinic of Radiotherapy, University Hospital of Schleswig Holstein, Campus Kiel, Kiel 24105, Germany
    Med Phys 36:3406-12. 2009
    ..The inter- and intraobserver errors should, however, be taken into account. A lower gain setting of the ultrasound system reduces the intraobserver error...
  55. pmc Sunlight intensity based global positioning system for near-surface underwater sensors
    Javier V Gómez
    Department of Systems and Automation, Carlos III University of Madrid, Avda de la Universidad 30, 28911 Leganes, Madrid, Spain
    Sensors (Basel) 12:1930-49. 2012
    ..Unlike previous localization techniques for underwater sensors, the current approach does not rely on stationary or mobile reference points...
  56. ncbi Theoretical study of liquid-immersed exposed-core microstructured optical fibers for sensing
    S C Warren-Smith
    Centre of Expertise in Photonics, School of Chemistry and Physics, The University of Adelaide, Adelaide, SA 5005, Australia
    Opt Express 16:9034-45. 2008
    ..This work demonstrates that, for fiber dimensions of interest, the exposed-core fiber is an attractive new sensor technology...
  57. pmc Ultrasonic sensitivity of strain-insensitive fiber Bragg grating sensors and evaluation of ultrasound-induced strain
    Hiroshi Tsuda
    National Institute of Advanced Industrial Science and Technology AIST Tsukuba Central 2, Tsukuba, 305 8568, Japan
    Sensors (Basel) 10:11248-58. 2010
  58. ncbi Modeling of piezoelectric transducers with combined pseudospectral and finite-difference methods
    E Filoux
    Universite Francois Rabelais, INSERM U930 CNRS FRE 2448, UFR de Medecine, 10 Bd Tonnellé, BP 3223, 37032 Tours Cedex 1, France
    J Acoust Soc Am 123:4165-73. 2008
    A new hybrid finite-difference (FD) and pseudospectral (PS) method adapted to the modeling of piezoelectric transducers (PZTs) is presented...
  59. pmc Experimental assessment of different receiver structures for underwater acoustic communications over multipath channels
    Guosong Zhang
    Department of Electronics and Telecommunications, Norwegian University of Science and Technology NTNU, Trondheim NO 7491, Norway
    Sensors (Basel) 12:2118-35. 2012
    ..In the assessment, it is found that: (1) it is advantageous to obtain spatial gain using the adaptive multichannel combining scheme; and (2) the MP algorithm improves the performance of communications using PPC processing...
  60. pmc Development of integrated preamplifier for high-frequency ultrasonic transducers and low-power handheld receiver
    Hojong Choi
    National Institutes of Health Resource Center for Medical Ultrasonic Transducer Technology and the Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 58:2646-58. 2011
    ..of an integrated preamplifier with a Sallen-Key Butterworth filter for very-high-frequency ultrasonic transducers and a low-power handheld receiver. This preamplifier was fabricated using a 0...
  61. ncbi Ultrasonic ranging sensor using simultaneous emissions from different transducers
    Alvaro Hernandez
    Electronics Department, University of Alcala, Alcala de Henares, 28806 Madrid, Spain
    IEEE Trans Ultrason Ferroelectr Freq Control 51:1660-70. 2004
    In recent applications based on ultrasound, several ultrasonic transducers have been geometrically and electronically associated to constitute a global sensor...
  62. pmc Micromachined high frequency PMN-PT/epoxy 1-3 composite ultrasonic annular array
    Changgeng Liu
    Geospace Research, Inc, 525 South Douglas Street, Suite 290, El Segundo, CA, USA
    Ultrasonics 52:497-502. 2012
    ..5 dB at 50 MHz and the crosstalk between adjacent elements was about -35 dB. The micromachining techniques described in this paper are promising for the fabrication of other types of high frequency transducers, e.g. 1D and 2D arrays.
  63. pmc Design and fabrication of PZN-7%PT single crystal high frequency angled needle ultrasound transducers
    Qifa Zhou
    IEEE Trans Ultrason Ferroelectr Freq Control 55:1394-9. 2008
    ..The two-way insertion loss was approximately 17 dB. Wire phantom imaging using fabricated PZN-7%PT single crystal transducers was obtained and spatial resolutions were assessed.
  64. ncbi High accuracy non-contact ultrasonic thickness gauging of aluminium sheet using electromagnetic acoustic transducers
    S Dixon
    Department of Physics, University of Warwick, Coventry, UK
    Ultrasonics 39:445-53. 2001
    ..However temporal measurements of these signals yield lower accuracy results when compared to the Fourier analysis method which is capable of sub-micron accuracy...
  65. pmc AURP: an AUV-aided underwater routing protocol for underwater acoustic sensor networks
    Seokhoon Yoon
    School of Electrical Engineering, University of Ulsan, Ulsan 680 749, Korea
    Sensors (Basel) 12:1827-45. 2012
  66. ncbi Performance evaluation of sensing fabrics for monitoring physiological and biomechanical variables
    Enzo Pasquale Scilingo
    Interdepartmental Research Center E Piaggio, University of Pisa, Pisa 56126, Italy
    IEEE Trans Inf Technol Biomed 9:345-52. 2005
    ..The performance of fabric electrodes has been investigated and compared with standard clinical electrodes...
  67. ncbi Analytical applications of aptamers
    S Tombelli
    Universita degli Studi di Firenze, Dipartimento di Chimica, Polo Scientifico, Via della Lastruccia 3, 50019 Sesto Fiorentino FI, Italy
    Biosens Bioelectron 20:2424-34. 2005
    ..In this review, the main analytical methods, which have been developed using aptamers, will be discussed together with an overview on the aptamer selection process...
  68. ncbi Fabricating capacitive micromachined ultrasonic transducers with a novel silicon-nitride-based wafer bonding process
    Andrew Logan
    Advanced Micro Nano Devices Laboratory at the University of Waterloo, Waterloo, ON, Canada
    IEEE Trans Ultrason Ferroelectr Freq Control 56:1074-84. 2009
    ..This paper presents the fabrication process and some characterization results...
  69. ncbi Particle separation using ultrasound can radically reduce embolic load to brain after cardiac surgery
    Henrik Jonsson
    Department of Cardiothoracic Surgery, Center for Heart and Lung Disease, Lund University Hospital, Lund, Sweden
    Ann Thorac Surg 78:1572-7. 2004
    ..A newly developed technique based on acoustic standing-wave separation of particles in fluid in microchannels, with the capacity to remove lipid particles in blood, is presented...
  70. ncbi The role of quantitative Schlieren assessment of physiotherapy ultrasound fields in describing variations between tissue heating rates of different transducers
    Lennart D Johns
    Department of Physical Therapy, Quinnipiac University, Hamden, CT 06518, USA
    Ultrasound Med Biol 33:1911-7. 2007
    Differences in tissue heating rates between ultrasound transducers have been well documented; however, comparative analysis between ultrasound fields to determine why tissue heating rates may differ is lacking...
  71. pmc Three-dimensional fluorescence-enhanced optical tomography using a hand-held probe based imaging system
    Jiajia Ge
    Optical Imaging Laboratory, Department of Biomedical Engineering, Florida International University, Miami, Florida 33174, USA
    Med Phys 35:3354-63. 2008
    ..Extensive tomography studies are currently carried out to determine the resolution and performance limits of the imager on flat and curved phantoms...
  72. ncbi Application of mass fabricated silicon-based gold transducers for amperometric biosensors
    Robert Ziółkowski
    Faculty of Chemistry, Department of Microbioanalytics, Warsaw University of Technology, Noakowskiego 3, 00 664 Warsaw, Poland
    Bioelectrochemistry 80:31-7. 2010
    The backside contact, silicon-based transducers with vacuum-deposited gold layer (BSC) are evaluated as the base for electrochemical biosensors construction...
  73. ncbi Determining the centre of pressure during walking and running using an instrumented treadmill
    G J Verkerke
    Department of Biomedical Engineering, Faculty of Medical Sciences, University of Groningen, A Deusinglaan 1, P O Box 196, 9700 AD Groningen, The Netherlands
    J Biomech 38:1881-5. 2005
    ..The design of the treadmill is based on the use of force transducers underneath a separate left and right plate, which together form the treadmill walking surface...
  74. ncbi Imaging of human tooth using ultrasound based chirp-coded nonlinear time reversal acoustics
    Serge Dos Santos
    Centre Val de Loire Université, Unitè Mixte de Recherche Imagerie et Cerveau INSERM U930 CNRS ERL 3106, Universit e François Rabelais ENI Val de Loire, Rue de la Chocolaterie, BP3410, 41034 Blois Cedex, France
    Ultrasonics 51:667-74. 2011
    ..It constitutes the basis of the self-consistent harmonic imaging sonography for monitoring cracks propagation in the dentine, responsible of human tooth structural health...
  75. ncbi Privacy-preserving telecardiology sensor networks: toward a low-cost portable wireless hardware/software codesign
    Fei Hu
    Department of Computer Engineering, Rochester Institute of Technology, Rochester, NY 14623, USA
    IEEE Trans Inf Technol Biomed 11:619-27. 2007
    ..S. Department of Health and Human Services. This research also designs a medical security scheme with low communication overhead to achieve confidential electrocardiogram data transmission in wireless medium...
  76. ncbi Capacitive micromachined ultrasonic transducers: next-generation arrays for acoustic imaging?
    Omer Oralkan
    Edward L Ginzton Laboratory, and Center for Integrated Systems, Stanford University, Stanford, CA 94305 4070, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 49:1596-610. 2002
    ..Recently, capacitive micromachined ultrasonic transducers (CMUTs) have emerged as an alternative technology offering advantages such as wide bandwidth, ease of ..
  77. ncbi Soft-tissue vibrations in the quadriceps measured with skin mounted transducers
    J M Wakeling
    Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada T2N 1N4
    J Biomech 34:539-43. 2001
    ..This technique resolved the vibration coefficients to 2 and 7% of the mean values for frequency and damping, respectively...
  78. ncbi Liquid-core optical ring-resonator sensors
    Ian M White
    Department of Biological Engineering, University of Missouri Columbia, Missouri 65211, USA
    Opt Lett 31:1319-21. 2006
  79. ncbi Optimum threshold setting for a positron-sensitive probe with background rejection capability
    Seiichi Yamamoto
    Department of Electrical Engineering, Kobe City College of Technology, Japan
    Ann Nucl Med 18:251-6. 2004
    ..3 of the peak level of the pulse for the plastic scintillator and 0.7 of that for the BGO. With these threshold levels, the background counts could be decreased to less than 0.2% of the true positron counts...
  80. ncbi Application of silicon sensor technologies to tumor tissue in vitro: detection of metabolic correlates of chemosensitivity
    Pedro Mestres-Ventura
    Institute Anatomy and Cell Biology, University of Saarland, Germany
    Methods Mol Med 111:109-25. 2005
    ..Evaluation of results and selection of controls are also discussed...
  81. ncbi Generation of ultraharmonics in surfactant based ultrasound contrast agents: use and advantages
    R Basude
    Department of Biomedical Engineering Science and Health Systems, Drexel University, Philadelphia, PA 19104, USA
    Ultrasonics 39:437-44. 2001
    ..Additionally, ultraharmonic (3f0/2) enhancements of approximately 23 dB at 100 kPa, approximately 35 dB at 0.5 MPa and approximately 41dB at 1.1 MPa for ST68-PFC, offer much greater signal to noise ratio than higher harmonics...
  82. ncbi Estimation of upper-limb orientation based on accelerometer and gyroscope measurements
    Rick A Hyde
    Department of Mechanical Engineering, University of Bristol, University Walk, Bristol BS8 1TR, U K
    IEEE Trans Biomed Eng 55:746-54. 2008
    ..Good estimation accuracy up to 15 Hz is indicated, and this with a reduced total sensor count of 18 compared to 24 that would be required for more conventional estimator architectures...
  83. ncbi Optimization of long-range BOTDA sensors with high resolution using first-order bi-directional Raman amplification
    Marcelo A Soto
    Scuola Superiore Sant Anna, Pisa, Italy
    Opt Express 19:4444-57. 2011
    ..1°C respectively...
  84. pmc Real-time optoacoustic monitoring and three-dimensional mapping of a human arm vasculature
    Matthew P Fronheiser
    Seno Medical Instruments, 3838 Medical Drive, San Antonio, Texas 78229, USA
    J Biomed Opt 15:021305. 2010
    ..Finally, we use frame-by-frame analysis of the recorded OA video to measure dynamic changes of the crossection of the ulnar artery...
  85. ncbi Fabrication and characterization of whispering-gallery-mode resonators made of polymers
    Judith R Schwesyg
    Institute of Physics, University of Bonn, Wegelerstr 8, 53115 Bonn, Germany
    Opt Express 17:2573-8. 2009
    ..The Q-factor in the infrared regime is limited by material absorption to 3 x 10(5) At 635 nm the Q-factor is limited by surface scattering only and reaches 4 x 10(7), which is a new record for polymers...
  86. ncbi Development of an oligo(ethylene glycol)-based SPR immunosensor for TNT detection
    Yutaka Mizuta
    Faculty of Information Science and Electrical Engineering, Kyushu University, 744 Motooka, Nishi ku, Fukuoka shi, Fukuoka 819 0395, Japan
    Biosens Bioelectron 24:191-7. 2008
    ..The sensor surfaces are durable for more than 100 times repeated use without any noticeable deterioration by their chemical stability and rather mild regeneration condition...
  87. ncbi Label-free biosensing based on single gold nanostars as plasmonic transducers
    Srujan K Dondapati
    Photonics and Optoelectronics Group, Physics Department and Center for Nanoscience CeNS, Ludwig Maximilians Universität München, Amalienstrasse 54, 80799 Munich, Germany
    ACS Nano 4:6318-22. 2010
    ..Concentrations as low as 0.1 nM produce a shift of the tip related plasmon resonances of about 2.3 nm (5.3 meV)...
  88. ncbi High frequency broadband PZT thick film ultrasonic transducers for medical imaging applications
    Q Q Zhang
    Geospace Research Inc, El Segundo, CA 90245, USA
    Ultrasonics 44:e711-5. 2006
    ..Beam profile measurements show that the transducer has an axial resolution of 9.2 microm and a lateral resolution of 33 microm...
  89. pmc Magnetomotive nanoparticle transducers for optical rheology of viscoelastic materials
    Vasilica Crecea
    Department of Physics, University of Illinois at Urbana Champaign, 1110 W Green St, Urbana, IL 61801, USA
    Opt Express 17:23114-22. 2009
    ..This real-time non-destructive technique constitutes a novel way of probing the natural frequencies of viscoelastic materials in which magnetic nanoparticles can be introduced...
  90. ncbi Organic thin-film transistors as transducers for (bio)analytical applications
    Carmen Bartic
    IMEC vzw, MCP ART, Leuven, Belgium
    Anal Bioanal Chem 384:354-65. 2006
    ..Detection principle, device configuration, materials and fabrication processes as well as sensor performances will be discussed, with emphasis on the potential for implementation in real applications and the important challenges ahead...
  91. ncbi Validation of antibody-based recognition by piezoelectric transducers through electroacoustic admittance analysis
    K Bizet
    UPR15 du CNRS Physique des Liquides et Electrochimie, , Paris, France
    Biosens Bioelectron 13:259-69. 1998
    The development of immunosensors based on piezoelectric transducers is widely investigated due to their attractive potentialities...
  92. ncbi Analysis of optical pulse coding in spontaneous Brillouin-based distributed temperature sensors
    Marcelo A Soto
    Scuola Superiore Sant Anna, Pisa, Italy
    Opt Express 16:19097-111. 2008
  93. ncbi Ultrasonic mixing in microfluidic channels using integrated transducers
    Goksen G Yaralioglu
    Stanford University, Ginzton Laboratory, Stanford, CA 94305, USA
    Anal Chem 76:3694-8. 2004
    ..The ultrasound is introduced into the channel by integrated piezoelectric transducers. The transducers are made of a zinc oxide thin film, which is deposited on the bottom surface of a quartz ..
  94. ncbi Generation and detection of guided waves using PZT wafer transducers
    Jeroen H Nieuwenhuis
    Institute of Sensor and Actuator Systems, Vienna University of Technology, Vienna, Austria
    IEEE Trans Ultrason Ferroelectr Freq Control 52:2103-11. 2005
    ..We show that the received signals for A0 and S0 modes have maxima near the frequencies predicted from the previously published point-force model...
  95. ncbi Sensor evaluation for wearable strain gauges in neurological rehabilitation
    Toni Giorgino
    Laboratory for Biomedical Informatics, Dipartimento di Informatica e Sistemistica, University of Pavia, Pavia, Italy
    IEEE Trans Neural Syst Rehabil Eng 17:409-15. 2009
    ..Real-time feedback on exercise progress can also be provided by reconstructing the sequence of consecutive positions assumed by the limb...
  96. pmc Selective detection of live pathogens via surface-confined electric field perturbation on interdigitated silicon transducers
    Roberto de la Rica
    Department of Chemistry and Biochemistry, City University of New York Hunter College, 695 Park Avenue, New York, New York 10065, USA
    Anal Chem 81:3830-5. 2009
  97. ncbi Evaluation of ultraviolet C for disinfection of endocavitary ultrasound transducers persistently contaminated despite probe covers
    Guillaume Kac
    Hygiene Hospitaliere, Paris, France
    Infect Control Hosp Epidemiol 31:165-70. 2010
  98. ncbi Lab-on-a-chip with integrated optical transducers
    S Balslev
    MIC Department of Micro and Nanotechnology Technical University of Denmark DTU Oersteds Plads, Building 345 east, DK 2800, Kongens Lyngby, Denmark
    Lab Chip 6:213-7. 2006
    ..Electrical read-out is accomplished by integrated metal connectors. To our knowledge, this is the first time that integration of all these components has been demonstrated...
  99. ncbi Sensorless freehand 3D ultrasound in real tissue: speckle decorrelation without fully developed speckle
    Andrew H Gee
    University of Cambridge, Department of Engineering, Trumpington Street, Cambridge, Cambs CB2 1PZ, UK
    Med Image Anal 10:137-49. 2006
    ..This leads to an adapted elevational decorrelation scheme which allows for the coherent scattering. Using the adapted scheme, we demonstrate markedly improved reconstructions of animal tissue in vitro...
  100. ncbi Subsample interpolation strategies for sensorless freehand 3D ultrasound
    R James Housden
    University of Cambridge, Department of Engineering, Trumpington Street, Cambridge CB2 1PZ, UK
    Ultrasound Med Biol 32:1897-904. 2006
    ..The new technique is shown to be superior, limiting interpolation errors to around 5% of the length of the freehand reconstruction...
  101. ncbi In vivo variability in quantitative coronary ultrasound and tissue characterization measurements with mechanical and phased-array catheters
    Gaston A Rodriguez-Granillo
    Thoraxcenter, Erasmus Medical Center, Bd406, Dr Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands
    Int J Cardiovasc Imaging 22:47-53. 2006
    ..Only limited evaluation of the in vivo agreement of volumetrical measurements between such systems has been performed, despite the fact that such information is essential for the conduction of atherosclerosis regression trials...

Research Grants76

  1. Targeting Inflammation for the Amelioration of Cisplatin-Hearing Loss
    Vickram Ramkumar; Fiscal Year: 2011
    ..Recent findings from our laboratories indicate that TRPV1 and NOX3 can increase the activity of signal transducers and activators of transcription (STAT1), an important mediator of inflammation...
  2. Regulation of TGF-beta Signaling and Embryonic Development by GTPases
    Gerald H Thomsen; Fiscal Year: 2010
    ..made a breakthrough by discovering that GTPBP1 and GTPBP2 interact with Smad proteins, the principal signal transducers for the Transforming Growth Factor-[unreadable], (TGF[unreadable]) superfamily...
  3. Prenatal stress biology, infant body composition and obesity risk
    Sonja Entringer; Fiscal Year: 2013
    ..biological stress parameters may act as "sensors" of the quality of the intrauterine environment as well as "transducers" of its effects on the developing fetus and subsequent childhood and adult obesity risk...
  4. Mac-1 (CR3) and Fc gamma receptors in immune-mediated neutrophil cytotoxicity
    Tanya N Mayadas; Fiscal Year: 2013
    ..several Mac-1 and Fc?R mediated adhesive functions in neutrophils, 2) identify Vav proteins as the major signal transducers of NADPH oxidase activation following Fc?R engagement, through regulation of Rac GTPases and phosphorylation of ..
  5. Ionic Liquid Gas Sensors for Detection of Flammable Gases In Workplace
    Xiangqun Zeng; Fiscal Year: 2010
    ..real-time, portable, low cost characters of orthogonal Electrochemical and Quartz Crystal Microbalance (QCM) transducers to develop an integrated flammable gas detector widely applicable as a standalone/hand-held gas detector at gas ..
  6. The regulation and activation of STATs in adipocytes
    Jacqueline M Stephens; Fiscal Year: 2013
    ..We have focused on STATs (Signal Transducers and Activators of Transcription), a family of transcription factors whose activity is largely controlled by ..
  7. Novel functions of RGS3
    Nickolai O Dulin; Fiscal Year: 2012
    ..Our new data suggest that a) RGS3 interacts with the transducers of TGF-2 signaling, Smad transcription factors that were previously thought to be unrelated to G protein / RGS ..
  8. Molecular genetics of egg activation and pronuclear function in Drosophila
    ..We will test whether two other important transducers of calcium signals are also required for activation...
  9. Stat3 in Epitherlial Carcinogenesis
    John DiGiovanni; Fiscal Year: 2012
    The primary goal of the research in this competitive renewal application is to understand the role of signal transducers and activators of transcription (Stats), particularly Stat3, in epithelial carcinogenesis...
    Yongwon Choi; Fiscal Year: 2010
    ..Dr. Hunter will study how various cytokines and signal transducers activate and properly limit peripheral T cell responses to pathogens...
  11. Low-cost handheld medical device for neuroaxial anesthesia guidance in the obese
    FRANK WILLIAM MAULDIN; Fiscal Year: 2012
    ..Key technological innovations of this project include an ultrasound system with a low number of single-element transducers and multi-modality position sensing, which is technologically advanced over standard ultrasound due to reduced ..
  12. Role of elF2a phosphorylation and ER stress in hypoxia tolerance and tumor growth
    Constantinos Koumenis; Fiscal Year: 2013
    ..The overall hypothesis of this proposal is that the ISR transducers PERK and GCN2 which are activated under conditions of tumor microenvironmental stress, activate pathways that ..
  13. TORC2-dependent regulation of gluconeogensis
    MICHAEL DALE CONKRIGHT; Fiscal Year: 2012
    ..Our recent experiments identifying a new component of the cAMP pathway, TORCs (Transducers of Regulated CREB), have established that cAMP signaling is more sophisticated than previously recognized and ..
  14. Adipokine Signaling in Macrophages
    Ling Qi; Fiscal Year: 2013
    ..distinctive pathways in macrophages? Remarkably, our recent data support the notion that macrophage TORC2 (for Transducers Of Regulated CREB activity 2) controls macrophage activation via a unique mechanism, involving nuclear-..
  15. Inhibitor of differentiation-1 mediates antifibrotic effects of carbon monoxide
    ERIN DANIELLE MORSE; Fiscal Year: 2012
    ..3) Establish the relationship between Id1/Dril1 and the Smad family of signal transducers. Relevance of this research to public health - Fibrosis is a feature of many chronic diseases, and the ..
  16. Developmental Ah receptor Activity in the CNS: Neurogenesis and Neurotoxicity
    Lisa A Opanashuk; Fiscal Year: 2013
    ..These transcription factors serve as environmental sensors and transducers of physiological signals, particularly during development. The endogenous functions of AhR remain unknown...
  17. Sniffer Biosensors Based on Ion Channel-GPCR Chimeras and Polylipid Membranes
    STEVEN SCOTT SAAVEDRA; Fiscal Year: 2013
    ..the IC and GPCR subunits in functional ICCRs, and this information will be used to design more responsive ICCR transducers. c) Sensors based on ICCRs containing the D2 dopamine and glucagon receptors will be prepared and evaluated for ..
  18. Mechanisms of how nuclear envelope bridges link nuclei to the cytoskeleton.
    Daniel A Starr; Fiscal Year: 2013
    ..of the KASH-SUN bridge in nuclear migration;they could serve simply as outer nuclear docking sites or, also as transducers of force across the nuclear envelope...
  19. 3D Ultrasound Guidance of Interventional Devices
    Stephen William Smith; Fiscal Year: 2012
    ..the clinical benefits of real-time 3-D ultrasound for transthoracic cardiovascular applications using 2-D array transducers as originally developed in our laboratories at Duke University...
  20. Photonic Crystal Surfaces for Label-Free Detection and Fluorescence Amplification
    LILA OTT VODKIN; Fiscal Year: 2012
    ..large area PC surfaces have been developed by the Cunningham Group at Illinois as multifunctional optical transducers that can be designed to produce narrow-wavelength electromagnetic resonances at any desired wavelength, ..
  21. Role of Gbeta 2 in the Nucleus of Angiotensin Receptor Activated Cells
    Anushree Bhatnagar; Fiscal Year: 2010
    ..GP is a component of heterotrimeric G proteins which are vital transducers of GPCR signals...
  22. Deficiency of SHP-1 expression and function in multiple sclerosis
    Paul T Massa; Fiscal Year: 2010
    ..We showed that SHP-1 deficiency plays a direct role in the hyper- activation of signal transducers and activators of transcription (STAT6 and STAT1)) and NF-?B...
  23. PI(3,4,5)P3 Regulates Cell Polarity During Chemotaxis and Cytokinesis
    Christopher Janetopoulos; Fiscal Year: 2012
    ..These G proteins are extremely important signal transducers and the receptors that couple to them are major targets for drugs by pharmaceutical companies...
  24. Training and research application for c-spine ultrasound of an aging population.
    DANIEL BUCKLAND; Fiscal Year: 2013
    ..The alignment and co-registration of images from dual ultrasound transducers, combined with an assumption of rigid body motion will be used to calculate the motion of contiguous cervical ..
  25. Role and Activation Status of IRS1/2 in IL-4-induced Protection from Cell Death.
    HOLLY A PORTER; Fiscal Year: 2010
    ..There are two main signaling pathways activated by IL-4;the STAT6, signal transducers and activators of transcription, pathway that results in expression of IL-4-responsive genes and the IRS1/2 ..
  26. Sexual dimorphisms of renin-angiotensin system in hypertension and renal injury
    Jennifer C Sullivan; Fiscal Year: 2013
    ..cortex of male and female SHR, focusing on superoxide, transforming growth factor-2, and Janus kinase/signal transducers and activators of transcription...
  27. Ultrasound assisted thrombolysis for acute pulmonary embolism
    CURTIS GENSTLER; Fiscal Year: 2012
    ..High power catheter transducers can produce effectual acoustic pressures across the massive pulmonary embolus...
  28. Biology of Alpha Particle Immunotherapy
    David A Scheinberg; Fiscal Year: 2013
    ..potential mechanisms of cellular resistance to alpha particle damage including: a) DNA damage sensors and transducers or apoptosis mediators or cell cycle checkpoints that distinguish alpha-resistant from sensitive cells or ..
  29. STRAP and Smad 7 Signaling in Colorectal Carcinomas
    Pran K Datta; Fiscal Year: 2013
    ..However, inactivating mutations in the TGF-[unreadable] type II receptor and selected TGF-[unreadable] signal transducers (Smad2/4), and reduced expression of receptors are not enough (around 55%) to account for the high frequency of ..
    Pinfen Yang; Fiscal Year: 2009
    ..on structural analysis and informative Chlamydomonas mutants, the radial spokes operate as mechano-chemical transducers to control dynein via a network of kinases, phosphatases and calcium sensors...
  31. Controlled Release Scaffolds for Nerve Regeneration
    Lonnie D Shea; Fiscal Year: 2013
    ..Additionally, our gene delivery transducers macrophages, and we will investigate strategies to promote a more regenerative phenotype (M2) rather than a ..
  32. Genetic Rescue of Retinoid-Induced Dysfunction
    Pilar Ruiz-Lozano; Fiscal Year: 2013
    ..into the retinoid- mediated signaling in the myocardium, we have evaluated the role of several candidate signal transducers in the myocytes and have recently discovered that mutation of a novel orphan type I - GPCR rescues dilated ..
  33. Rapid, sensitive and labor-free immunoassays for sepsis based on magnetic nanoflu
    Hur Koser; Fiscal Year: 2013
    ..Advancements in micro- and Nanotechnology have led to a myriad of direct detection schemes and sensitive transducers for biological assays...
  34. Photoacoustic endoscopy of Barretts esophagus
    Qifa Zhou; Fiscal Year: 2013
    ..Design and develop a piezoelectric ring probe of improved sensitivity. We will design and engineer ultrasonic transducers optimized for the proposed photoacoustic endoscope...
  35. Type 1 IFN Function and Signaling in Immunity to Viruses
    CHRISTINE ANNE BIRON; Fiscal Year: 2013
    ..The cytokines do stimulate a signaling pathway, depending on the signal transducers and activators of transcription (STAT) 1 and 2, but they can conditionally activate all of the STATs, including ..
    Craig J Hartley; Fiscal Year: 2012
    Our general goals have been to develop ultrasonic instrumentation, transducers, and techniques for evaluation of cardiovascular physiology and function in man and in animal models of human diseases and conditions, and recently we have ..
  37. Molecular and Force Dynamics: Leukocyte Adhesion Molecules
    SCOTT IRWIN SIMON; Fiscal Year: 2013
    ..2) Determine how E-selectin ligands on neutrophils serve as mechano-transducers that trigger and amplify chemokine signaling of integrin activation on inflamed endothelium 3) define the ..
  38. Single-molecule nanomagnetic assays for ultrasmall sample clinical diagnostics
    Dmitri Litvinov; Fiscal Year: 2010
    ..These trends, which are expected to continue for the foreseeable future, call for transducers compatible with hybridization assays and molecular binding, implementable in parallel formats, with high ..
  39. Percutaneous cardiac HIFU ablation with multimodal image guidance
    Douglas N Stephens; Fiscal Year: 2013
    ..This self-heating of piezoelectric transducers was partly responsible for the collateral damage experienced in early cardiac HIFU attempts...
  40. Vevo 2100 High Resolution Ultrasound System For Preclinical Cancer Imaging
    Paul A Dayton; Fiscal Year: 2012 and a collaborator that specializes in transducer design for this platform will provide prototype transducers to our group for testing and feedback...
  41. 3D Hybrid Optoacoustic-Ultrasonic System for Diagnostic Imaging of Breast Cancer
    Alexander A Oraevsky; Fiscal Year: 2013
    ..we propose a fast-track SBIR project to resolve technical issues associated with ultrawide-band ultrasonic transducers made of a novel piezoelectric ceramics (lead metaniobate), novel hardware, firmware and software that combines ..
  42. Point of Care Ultrasound for Maternal Health
    LOWELL SCOTT SMITH; Fiscal Year: 2010
    ..The proposal aims to develop the capabilities of DMP for the construction of ultrasound transducers. If successful, there becomes an economic impetus to extend DMP to a high throughput, continuous process with ..
  43. Stage-specific Signaling in Peripheral B Cell Selection
    Wasif N Khan; Fiscal Year: 2010
    ..In Specific Aim 1, we will characterize T1- and T2-specific BCR signal transducers using cutting edge proteomics approaches...
  44. Toxins as molecular probes of pain transduction mechanisms
    JEREMIAH OSTEEN; Fiscal Year: 2013
    ..of primary afferent nerve fibers which mediate pain signals (nociceptors) and these channels are candidates as transducers of acidosis-triggered pain responses...
  45. Regulation of T cell activation and tolerance by Grail
    ..molecules on antigen-presenting cells, and on the other hand, also by delicate intracellular signal transducers and regulators...
    Thomas G Spiro; Fiscal Year: 2010
    ..Special emphasis will be placed on the new class of heme sensor proteins. The signal transducers CooA and the H-NOX family of proteins, as well as the heme-regulated enzyme cystathionine beta synthase, have ..
  47. Investigations of Human Auditory Mechanics
    Hideko Heidi Nakajima; Fiscal Year: 2012
    ..A new measurement technique based on fiberoptic micro- pressure transducers will be employed in human cadaveric specimens to obtain previously unavailable knowledge and test new ..
  48. MSI-FLASH: Paced Respiration for Breast Cancer Survivors
    Janet S Carpenter; Fiscal Year: 2012
    ..Portable respiratory transducers will be used to assess treatment integrity (rate and depth of breathing)...
  49. Multimode laser optoacoustic tomography system for breast cancer care
    Alexander A Oraevsky; Fiscal Year: 2013 laser ultrasonic 3D tomography imager based on rotating arc-shaped array of ultrawide-band ultrasonic transducers, (2) Develop and evaluate robust OAT image reconstruction methods for use with the developed imager, (3) ..
    Allan I Basbaum; Fiscal Year: 2013
    ..peptide and non-peptide classes of nociceptor, there is a complex array of thermal, mechanical and chemical transducers that define "pain" fibers...
  51. Assessing Use of Acoustic Radiation Force to Noninvasively Measure Liver Pressure
    ..will be deformed similarly to the strain state observed with hepatic pressurization and two ultrasound transducers will be used to determine whether ARFI-based stiffness metrics and knowledge of underlying material properties ..
    Karen M Lyons; Fiscal Year: 2013 extensive characterization of single, double, and triple mutant mice lacking BMP receptors or the downstream transducers R-Smads, we found that BMPs are required for nearly every aspect of growth plate chondrogenesis in vivo, and ..
  53. Airway sensors with myelinated afferents
    JERRY J YU; Fiscal Year: 2013
    ..In this application, we will test the hypothesis that vagal airway sensory units are not only transducers but also processors. Sensory units'behaviors depend on their structures...
  54. A Novel Ultrasound Phased Array and Sonication Method for Stroke Treatments
    Kullervo Hynynen; Fiscal Year: 2012
    In order to exploit the potential of focused ultrasound therapy, high-power phased array transducers with large number of elements are required. Current methods have two major drawbacks...
    Louis M Luttrell; Fiscal Year: 2013
    ..hypothesis of this proposal is that heterotrimeric G proteins and -arrestins serve as independent GPCR signal transducers that mediate distinct facets of the cellular response to GPCR stimulation...
    William E Russell; Fiscal Year: 2013
    ..signaling of the normal and regenerating liver;2) To evaluate the central role of the ErbB proteins as signal transducers of HGF...
  57. Nicotinamide Riboside and NAD+: Modulation of Sirtuins and Reactive Oxygen
    Anthony A Sauve; Fiscal Year: 2013
    ..are activated by nutritional stress, exemplified by low calorie diets, and are thought to be important signal transducers that adapt cells and human physiology...
  58. Mechanosensitive ion channels and cortical mechanics
    Frederick Sachs; Fiscal Year: 2013
    ..MSCs) are in all cells in all kingdoms, yet our biophysical understanding of how these channels function as transducers in the eukaryotic world lags in comparison to voltage and ligand-gated channels...
  59. Body size control genes & TGF-beta signaling C. elegans
    Cathy Savage Dunn; Fiscal Year: 2009
    ..pathway have previously been fruitful in identifying conserved signaling components, including the Smad signal transducers SMA-2, SMA-3, and SMA-4...
  60. 2012 Bioanalytical Sensors Gordon Research Conference and Gordon Research Seminar
    Steven Allan Soper; Fiscal Year: 2012
    ..enabling technologies including materials, molecular recognition, micro-/nanosystems, optical/electrochemical transducers and the utility of biosensors for monitoring a host of diseases...
  61. Vevo 2100 ultrasound scanner
    Flemming Forsberg; Fiscal Year: 2012
    ..funding for a Vevo 2100 ultrasound scanner (VisualSonics, Toronto, Ontario, Canada) with unique high frequency transducers (spanning frequencies from 24 to 70 MHz) in order to support many NIH-sponsored research projects within TJU ..
  62. Metrology and Nonlinear Acoustics Bioeffects of High Intensity Focused Ultrasound
    VERA KHOKHLOVA; Fiscal Year: 2013
    ..In Aim 2, high power transducers will be built and the methods for correlating exposimetry with bioeffects in tissue (ex vivo) will be developed ..
  63. Ultrasound guided site-specific gene delivery in prostate cancer
    Pier Paolo Claudio; Fiscal Year: 2010
    ..The gas filled microspheres effectively lower the energy threshold for cavitation. This allows diagnostic transducers operating within the energy levels mandated by the FDA to be used for drug/gene delivery...
    Kathryn LaNoue; Fiscal Year: 1993
    ..Adenosine receptors or the GTP binding proteins, which act as transducers for these receptors, may be important in normal regulation of lipid storage and may be altered in some forms of ..
  65. High Performance Single Crystal Ultrasound Device for Medical Imaging
    Jian Tian; Fiscal Year: 2009
    ..Low frequency (<20 MHz) ultrasonic transducers have been widely used in areas including cardiac, pediatrics, abdomen, vascular and urology...
  66. Coupling Strategies for Middle Ear Protheses
    ANN GRONDA; Fiscal Year: 2003
    ..clinical trials. The device consists of an indwelling, self-powered sound processor and separate piezoelectric transducers to sense incus vibrations and drive the stapes...
  67. 2009 Cellular Osmoregulation: Sensors, Transducers & Regulators GRC
    PAUL YANCEY; Fiscal Year: 2009
    ..Sensors, transducers and regulators ameliorate the consequences of those perturbations by modulating the accumulation and release of ..
  68. Functional brain imaging by laser-induced PAT
    Lihong Wang; Fiscal Year: 2007
    ..the order of 10 mK caused by the laser irradiation, are then measured around the sample by wide-band ultrasonic transducers. The acquired photoacoustic waves are used to reconstruct, at ultrasonic resolution, the optical absorption ..
  69. Micromachined 7MHz Two Dimensional Forward Looking Ultrasound Medical Penetrative
    ELI WIENER AVNEAR; Fiscal Year: 2009
    ..most popular ultrasound imaging is currently provided by the pulse-echo modality, in which the piezoelectric transducers act as both acoustic sources and detectors of the ultrasound waves...
  70. Registered Ultrasound-Endoscope
    Sharif Razzaque; Fiscal Year: 2009 applicant): The proposed project here aims to facilitate the use of laparoscopically mounted ultrasound transducers during minimally invasive surgical (MIS) procedures...
  71. A Real-Time, Label-Free Diagnostic Platform with Glycan Arrays
    Charles Greef; Fiscal Year: 2007
    ..Design and prepare mono- and disaccharide substituted polymeric transducers; 2. Optimize binding density, multi-valency and mitigate nonspecific binding; 3...
  72. Development and evaluation of a novel SOCS1-silenced HIV vaccine
    Jerry Blackwell; Fiscal Year: 2009
    ..protein functions as an antigen-presentation attenuator by restricting the Janus-activated kinase-signal transducers and activators of transcription and Toll-like receptor-signaling pathways...
  73. Biomechanical effects of manual therapy in healthy and impaired shoulders
    Kevin McQuade; Fiscal Year: 2009
    ..15 healthy and 15 non-healthy shoulders using real-time magnetic tracking sensors, and subminiature force transducers that are attached to clinicians hands as they perform manual therapy techniques...
    Alan Snyder; Fiscal Year: 2004
    ..have found important uses in a variety of industrial, consumer and military systems, as well as in ultrasonic transducers for medical imaging, flow measurement and therapy...
    Philip Troyk; Fiscal Year: 1990
    ..Integrated circuits, (micro-transducers) are needed to provide sensing and control functions to further the development of implantable electronic ..
    HARVEY FLORMAN; Fiscal Year: 2004
    ..Consequently, these studies may also provide a model for the functions of TRP channels in other tissues. ..