sutures

Summary

Summary: Materials used in closing a surgical or traumatic wound. (From Dorland, 28th ed)

Top Publications

  1. ncbi Interrupted or continuous slowly absorbable sutures for closure of primary elective midline abdominal incisions: a multicenter randomized trial (INSECT: ISRCTN24023541)
    Christoph M Seiler
    Study Center of the German Surgical Society, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    Ann Surg 249:576-82. 2009
  2. pmc Absorbable versus silk sutures for surgical treatment of trachomatous trichiasis in Ethiopia: a randomised controlled trial
    Saul N Rajak
    The London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Med 8:e1001137. 2011
  3. pmc Sutures versus staples for skin closure in orthopaedic surgery: meta-analysis
    Toby O Smith
    Norfolk and Norwich University Hospital, Norwich NR2 7UY
    BMJ 340:c1199. 2010
  4. ncbi Unidirectional barbed suture versus continuous suture with intracorporeal knots in laparoscopic myomectomy: a randomized study
    Franco Alessandri
    Department of Obstetrics and Gynecology, San Martino Hospital and University of Genoa, Genoa, Italy
    J Minim Invasive Gynecol 17:725-9. 2010
  5. ncbi Bacterial adherence to surgical sutures: can antibacterial-coated sutures reduce the risk of microbial contamination?
    Charles E Edmiston
    Division of Vascular Surgery, Department of Surgery, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA
    J Am Coll Surg 203:481-9. 2006
  6. ncbi Review paper: absorbable polymeric surgical sutures: chemistry, production, properties, biodegradability, and performance
    Chennakkattu Krishna Sadasivan Pillai
    Division of Biosurface Technology, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Poojappura, Thiruvananthapuram 695 012, India
    J Biomater Appl 25:291-366. 2010
  7. ncbi The effect of recombinant human platelet-derived growth factor BB-coated sutures on rotator cuff healing in a sheep model
    Christopher Uggen
    Kerlan Jobe Orthopaedic Clinic, Los Angeles, California, U S A
    Arthroscopy 26:1456-62. 2010
  8. ncbi Barbed suture for renorrhaphy during robot-assisted partial nephrectomy
    Jesse Sammon
    Vattikuti Urology Institute, Henry Ford Hospital, Detroit, Michigan 48202, USA
    J Endourol 25:529-33. 2011
  9. ncbi Uterine compression sutures: surgical management of postpartum hemorrhage
    R G Hayman
    Department of Obstetrics and Gynaecology, Derby City Hospital, Derby, United Kingdom
    Obstet Gynecol 99:502-6. 2002
  10. ncbi Comparison of zones 1 to 4 flexor tendon repairs using absorbable and unabsorbable four-strand core sutures
    R H Caulfield
    Department of Plastic and Reconstructive Surgery, Chelsea and Westminster Hospital, London
    J Hand Surg Eur Vol 33:412-7. 2008

Detail Information

Publications352 found, 100 shown here

  1. ncbi Interrupted or continuous slowly absorbable sutures for closure of primary elective midline abdominal incisions: a multicenter randomized trial (INSECT: ISRCTN24023541)
    Christoph M Seiler
    Study Center of the German Surgical Society, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    Ann Surg 249:576-82. 2009
    ..The aim of this study is to compare: (1) interrupted technique with rapidly absorbable sutures and (2) continuous techniques with different slowly absorbable sutures, focusing on the incidence of incisional ..
  2. pmc Absorbable versus silk sutures for surgical treatment of trachomatous trichiasis in Ethiopia: a randomised controlled trial
    Saul N Rajak
    The London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Med 8:e1001137. 2011
    ..Trichiasis can recur after corrective surgery. We tested the hypothesis that using absorbable sutures instead of silk sutures might reduce the risk of recurrent disease among patients with major trichiasis in a ..
  3. pmc Sutures versus staples for skin closure in orthopaedic surgery: meta-analysis
    Toby O Smith
    Norfolk and Norwich University Hospital, Norwich NR2 7UY
    BMJ 340:c1199. 2010
    To compare the clinical outcomes of staples versus sutures in wound closure after orthopaedic surgery.
  4. ncbi Unidirectional barbed suture versus continuous suture with intracorporeal knots in laparoscopic myomectomy: a randomized study
    Franco Alessandri
    Department of Obstetrics and Gynecology, San Martino Hospital and University of Genoa, Genoa, Italy
    J Minim Invasive Gynecol 17:725-9. 2010
    ..To estimate the effectiveness of unidirectional knotless barbed suture and continuous suture with intracorporeal knots in the repair of uterine wall defects during laparoscopic myomectomy...
  5. ncbi Bacterial adherence to surgical sutures: can antibacterial-coated sutures reduce the risk of microbial contamination?
    Charles E Edmiston
    Division of Vascular Surgery, Department of Surgery, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA
    J Am Coll Surg 203:481-9. 2006
    Surgical site infections are associated with severe morbidity and mortality. The role of surgical sutures in the etiology of surgical site infection has been the objective of discussion for decades...
  6. ncbi Review paper: absorbable polymeric surgical sutures: chemistry, production, properties, biodegradability, and performance
    Chennakkattu Krishna Sadasivan Pillai
    Division of Biosurface Technology, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Poojappura, Thiruvananthapuram 695 012, India
    J Biomater Appl 25:291-366. 2010
    Among biomaterials used as implants in human body, sutures constitute the largest groups of materials having a huge market exceeding $1.3 billion annually...
  7. ncbi The effect of recombinant human platelet-derived growth factor BB-coated sutures on rotator cuff healing in a sheep model
    Christopher Uggen
    Kerlan Jobe Orthopaedic Clinic, Los Angeles, California, U S A
    Arthroscopy 26:1456-62. 2010
    ....
  8. ncbi Barbed suture for renorrhaphy during robot-assisted partial nephrectomy
    Jesse Sammon
    Vattikuti Urology Institute, Henry Ford Hospital, Detroit, Michigan 48202, USA
    J Endourol 25:529-33. 2011
    ..We present the first clinical study of barbed suture for renorrhaphy during RAPN in human patients and compare perioperative outcomes to RAPN with polyglactin suture...
  9. ncbi Uterine compression sutures: surgical management of postpartum hemorrhage
    R G Hayman
    Department of Obstetrics and Gynaecology, Derby City Hospital, Derby, United Kingdom
    Obstet Gynecol 99:502-6. 2002
    ..The B-Lynch technique is a surgical procedure that may be used to arrest postpartum hemorrhage resulting from uterine atony...
  10. ncbi Comparison of zones 1 to 4 flexor tendon repairs using absorbable and unabsorbable four-strand core sutures
    R H Caulfield
    Department of Plastic and Reconstructive Surgery, Chelsea and Westminster Hospital, London
    J Hand Surg Eur Vol 33:412-7. 2008
    Absorbable sutures behave favourably in vitro and in an animal model. We report the outcome of flexor tendon injuries in a series of 272 consecutive patients treated over 45 months with a mean follow-up of 4 (range 3-12) months...
  11. ncbi Descemet-stripping automated endothelial keratoplasty by using suture for donor insertion
    Vincenzo Sarnicola
    Misericordia Hospital, Grosseto, Italy
    Cornea 27:825-9. 2008
    ..To describe a new technique for donor insertion in cases of Descemet-stripping automated endothelial keratoplasty (DSAEK)...
  12. ncbi Implantation of scleral-fixated posterior chamber intraocular lenses in adults
    Ole Kjeka
    Department of Ophthalmology, Haukeland University Hospital, Bergen, Norway
    Acta Ophthalmol 86:537-42. 2008
    ..To report the results of transscleral fixation of posterior chamber intraocular lenses in adults...
  13. ncbi Clinical applications of basic research that shows reducing skin tension could prevent and treat abnormal scarring: the importance of fascial/subcutaneous tensile reduction sutures and flap surgery for keloid and hypertrophic scar reconstruction
    Rei Ogawa
    Department of Plastic, Reconstructive and Regenerative Surgery, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 78:68-76. 2011
    ..Clinical trials revealed that subcutaneous/fascial tensile reduction sutures, which apply minimal tension on the dermis, are more effective in reducing recurrence than the three-layered ..
  14. ncbi First investigation of spider silk as a braided microsurgical suture
    Joern W Kuhbier
    Department of Plastic, Hand, and Reconstructive Surgery, Medical School Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Biomed Mater Res B Appl Biomater 97:381-7. 2011
    ..The constructed spider silk sutures showed a median thickness of 25 μm, matching the USP definition of 10-0...
  15. ncbi Decreased incidence of vaginal cuff dehiscence after laparoscopic closure with bidirectional barbed suture
    Matthew T Siedhoff
    Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, NC 27599 7570, USA
    J Minim Invasive Gynecol 18:218-23. 2011
    ..To estimate whether a new surgical technique is associated with lower incidence of postoperative breakdown of the vaginal cuff after laparoscopic hysterectomy or trachelectomy, compared with previous methods of closure...
  16. ncbi Impact of using triclosan-antibacterial sutures on incidence of surgical site infection
    Ibrahim Galal
    Department of Surgery, Cairo University Hospitals, Cairo, Egypt
    Am J Surg 202:133-8. 2011
    ..Surgical site infection is a common complication of surgery. Its morbidities range from delayed healing to systemic sepsis. It has impact on the economy and health care resources...
  17. ncbi Suture technique for Descemet stripping and endothelial keratoplasty
    Marian Sue Macsai
    Division of Ophthalmology, Evanston Northwestern Healthcare, Evanston, IL, USA
    Cornea 26:1123-6. 2007
    ..To describe a suture technique for Descemet stripping and endothelial keratoplasty (DSEK)...
  18. ncbi Triclosan-impregnated sutures to decrease surgical site infections: systematic review and meta-analysis of randomized trials
    Wai Keat Chang
    Department of Surgery, South Auckland Clinical School, Middlemore Hospital, University of Auckland, Otahuhu, Auckland, New Zealand
    Ann Surg 255:854-9. 2012
    To determine the efficacy and safety of triclosan-impregnated sutures.
  19. ncbi Sutures enriched with adipose-derived stem cells decrease the local acute inflammation after tracheal anastomosis in a murine model
    Tihomir Georgiev-Hristov
    Servicio de Cirugia General y del Aparato Digestivo, Hospital Universitario La Paz, Madrid, Spain
    Eur J Cardiothorac Surg 42:e40-7. 2012
    ..Little is known of their impact on acute inflammation, especially in the problematic tracheal area. We aimed to study the effect of ASCs applied locally in an animal model of tracheal resection and anastomosis...
  20. ncbi Randomized trial of antimicrobial-coated sutures to prevent surgical site infection after breast cancer surgery
    Nia Williams
    Department of Wound Healing and Dermatology, Cardiff University, Cardiff, United Kingdom
    Surg Infect (Larchmt) 12:469-74. 2011
    ..In a randomized clinical trial, antimicrobial-coated sutures were compared with their conventional counterparts, polyglactin and poliglecaprone, for skin closure after breast ..
  21. ncbi Evaluation of a novel knotless self-anchoring suture material for urinary tract reconstruction
    Kyle J Weld
    Division of Urology and Department of Pathology, Washington University School of Medicine, St Louis, Missouri, USA
    Urology 67:1133-7. 2006
    ..To evaluate a novel prototype self-anchoring suture (SAS) material that incorporates unidirectional "barbs" designed to grip and approximate tissue without the need for suture ligation for urinary tract reconstructive procedures...
  22. ncbi Surgical site infections after abdominal closure in colorectal surgery using triclosan-coated absorbable suture (PDS Plus) vs. uncoated sutures (PDS II): a randomized multicenter study
    József Baracs
    Department of Surgery, University of Pecs, Pecs, Hungary
    Surg Infect (Larchmt) 12:483-9. 2011
    ..The main goal of this study was to compare triclosan-coated and uncoated absorbable suture (PDS Plus(®) with PDS II(®)) in elective colorectal operations...
  23. ncbi Long-term active antimicrobial coatings for surgical sutures based on silver nanoparticles and hyperbranched polylysine
    Chau Hon Ho
    Freiburg Materials Research Center and Institute for Macromolecular Chemistry, Albert Ludwigs Universitaet Freiburg, Stefan Meier Str 21, 79104 Freiburg, Germany
    J Biomater Sci Polym Ed 24:1589-600. 2013
    The goal of this study was to develop a long-term active antimicrobial coating for surgical sutures. To this end, two water-insoluble polymeric nanocontainers based on hyperbranched polylysine (HPL), hydrophobically modified by either ..
  24. ncbi Intracostal sutures decrease the pain of thoracotomy
    Robert J Cerfolio
    Department of Cardiothoracic Surgery, University of Alabama at Birmingham, 35294, USA
    Ann Thorac Surg 76:407-11; discussion 411-2. 2003
    ..General thoracic surgeons spend much time dealing and treating patients' pain after thoracotomy...
  25. ncbi The effect of growth differentiation factor-5-coated sutures on tendon repair in a rat model
    Joshua S Dines
    The Hospital for Special Surgery, New York, NY, USA
    J Shoulder Elbow Surg 16:S215-21. 2007
    ..Tendons of 92 rats were transected and repaired with sutures. All researchers were blinded to the following treatment groups (24 rats in each group): 0 rhGDF (control), 24 ng/..
  26. ncbi Effect of triclosan-coated sutures on the incidence of surgical wound infection after lower limb revascularization surgery: a randomized controlled trial
    Johanna Turtiainen
    Department of Surgery, North Karelia Central Hospital, Tikkamäentie 1, Joensuu, 80210, Finland
    World J Surg 36:2528-34. 2012
    ..In a prospective study, triclosan-coated sutures were reported to decrease the incidence of surgical site infection after various surgical procedures...
  27. ncbi Use of abdominal quilting sutures for seroma prevention in TRAM flap reconstruction: a prospective, controlled trial
    Colleen McCarthy
    Division of Plastic Surgery, Department of Surgery, University of British Columbia, Vancouver, BC, Canada
    Ann Plast Surg 54:361-4. 2005
    This study is designed to evaluate the effect of abdominal quilting sutures on the incidence of abdominal seroma formation in patients undergoing pedicled transverse rectus abdominis musculocutaneous (TRAM) flap reconstruction...
  28. ncbi Replacement of chordae tendineae with polytetrafluoroethylene (PTFE) sutures in mitral valve repair: early and long-term results
    Bruno Chiappini
    Department of Cardiovascular and Thoracic Surgery, St Luc Hospital, Catholic University of Leuven, Brussels, Belgium
    J Heart Valve Dis 15:657-63; discussion 663. 2006
    ..The study aim was to review the authors' experience with polytetrafluoroethylene (PTFE), using a standardized technique for length adjustment, and to analyze the long-term results in patients who underwent mitral valve repair...
  29. ncbi Fibrin glue versus sutures for attaching the conjunctival autograft in pterygium surgery: a prospective observer masked clinical trial
    S Srinivasan
    Department of Ophthalmology, Toronto Western Hospital, Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada
    Br J Ophthalmol 93:215-8. 2009
    To compare the degree of conjunctival autograft inflammation, subconjunctival haemorrhage (SCH) and graft stability following the use of sutures or fibrin glue (FG) during pterygium surgery.
  30. pmc Antimicrobial activity of Calendula officinalis, Camellia sinensis and chlorhexidine against the adherence of microorganisms to sutures after extraction of unerupted third molars
    Raquel Lourdes Faria
    Sao Jose dos Campos Dental School, Univ Estadual Paulista, Sao Jose dos Campos, SP
    J Appl Oral Sci 19:476-82. 2011
    ..Camellia sinensis (L.) Kuntze and 0.12% chlorhexidine digluconate on the adherence of microorganisms to suture materials after extraction of unerupted third molars...
  31. ncbi Lichtenstein inguinal hernioplasty using butyl-2-cyanoacrylate versus sutures. Preliminary experience of a prospective randomized trial
    W Nowobilski
    Department of General and Gastroenterological Surgery, St Vincent a Paulo Hospital of Gdynia, Gdynia, Poland
    Eur Surg Res 36:367-70. 2004
    ..In the control group polypropylene mesh was anchored with 3/0 Dexon sutures, fascia and skin were closed with sutures 3/0 Dexon and 3/0 Monosof...
  32. ncbi The competency of pars plana vitrectomy incisions: a comparative histologic and spectrophotometric analysis
    Omesh P Gupta
    Retina Service, Wills Eye Institute, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Am J Ophthalmol 147:243-250.e1. 2009
    ..To compare the relative competency of pars plana vitrectomy (PPV) sclerotomies...
  33. ncbi A comparative study of tissue glue and vicryl suture for closing limbal-conjunctival autografts and histologic evaluation after pterygium excision
    Yasemin Ozdamar
    Ankara Ulucanlar Eye Research Hospital, Ankara, Turkey
    Cornea 27:552-8. 2008
    ..To compare clinical and histopathologic outcomes of tissue glue and vicryl suture to attach limbal conjunctival autografts in pterygium surgery...
  34. ncbi Three purse-string sutures allow immediate start of peritoneal dialysis with a low incidence of leakage
    Bernd G Stegmayr
    Department of Internal Medicine, University Hospital, Umea, Sweden
    Semin Dial 16:346-8. 2003
    ..This review describes various insertion techniques focusing on a surgical insertion technique using purse-string sutures to fix the peritoneum around the catheter with the inner cuff of a Tenckhoff catheter invaginated between purse-..
  35. ncbi Development and characterisation of silver-doped bioactive glass-coated sutures for tissue engineering and wound healing applications
    J J Blaker
    Department of Materials and Centre for Composite Materials, Centre for Tissue Engineering and Regenerative Medicine, Imperial College London, Prince Consort Road, London SW7 2BP, UK
    Biomaterials 25:1319-29. 2004
    ..glass powder (AgBG) was used to coat resorbable Vicryl (polyglactin 910) and non-resorbable Mersilk surgical sutures, thereby imparting bioactive, antimicrobial and bactericidal properties to the sutures...
  36. ncbi Arthroscopic knots and strength sutures for rotator cuff repair
    Umile Giuseppe Longo
    Department of Orthopaedic and Trauma Surgery, Campus Biomedico University, Trigoria, Rome, Italy
    Sports Med Arthrosc 19:251-65. 2011
    ..The strength of the repair is also influenced by the suture material used. In this study, we review the state-of-the-art of arthroscopic knots and suture materials being used for arthroscopic rotator cuff repair...
  37. ncbi Antibacterial [corrected] coating of abdominal closure sutures and wound infection
    Christoph Justinger
    Department of General, Visceral, Vascular, and Pediatric Surgery, University of Saarland, Homburg Saar, Germany
    Surgery 145:330-4. 2009
    ..The aim of this study was to ascertain if the use of Vicryl plus reduced the number of wound infections after midline laparotomy comparing to polydioxanon suture (PDS II)...
  38. ncbi Triclosan-coated sutures for the reduction of sternal wound infections: economic considerations
    Tatjana Fleck
    Department of Cardiothoracic Surgery, AKH Vienna, Medical University of Vienna, Vienna, Austria
    Ann Thorac Surg 84:232-6. 2007
    ..To decrease the incidence of infection, we evaluated triclosan-coated sutures for the closure of the sternal incision, as it is known that most of the surgical site infections are related to ..
  39. ncbi A new acrylic tissue adhesive for conjunctival surgery: experimental study
    Jorge L Alio
    Ophthalmology Department, Miguel Hernandez University, Alicante, Spain
    Ophthalmic Res 35:306-12. 2003
    To evaluate the clinical efficacy and the clinical and histopathologic tolerance of a new acrylic tissue adhesive (ADAL-2) versus 8/0 polyglactin sutures (Vicryl) for its use in conjunctival surgery.
  40. pmc S100A proteins in the pathogenesis of experimental corneal neovascularization
    Changyou Li
    Qingdao University SEI Joint Ophthalmology Program, Qingdao, China
    Mol Vis 16:2225-35. 2010
    ..Two of its members, S100A4 and A13, are thought to be pro-angiogenic in tumor development. This study examines whether S100A proteins are involved in the pathogenesis of inflammation-associated corneal neovascularization (CorNV)...
  41. pmc Long-term follow-up of a randomized controlled trial of suture versus mesh repair of incisional hernia
    Jacobus W A Burger
    Department of General Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands
    Ann Surg 240:578-83; discussion 583-5. 2004
    ..The objective of this study was to determine the best treatment of incisional hernia, taking into account recurrence, complications, discomfort, cosmetic result, and patient satisfaction...
  42. ncbi A new 25-gauge instrument system for transconjunctival sutureless vitrectomy surgery
    Gildo Y Fujii
    Microsurgery Advanced Design Laboratory, Doheny Eye Institute, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA
    Ophthalmology 109:1807-12; discussion 1813. 2002
    ..To introduce and evaluate the infusion and aspiration rates and operative times of the 25-gauge transconjunctival sutureless vitrectomy system (TSV) DESIGN: In vitro experimental and comparative interventional study...
  43. ncbi Effect of stitch length on wound complications after closure of midline incisions: a randomized controlled trial
    Daniel Millbourn
    Department of Surgery, Sundsvall Hospital, Sundsvall, Sweden
    Arch Surg 144:1056-9. 2009
    ..In midline incisions closed with a single-layer running suture, the rate of wound complications is lower when a suture length to wound length ratio of at least 4 is accomplished with a short stitch length rather than with a long one...
  44. ncbi Fibrin glue versus sutures for conjunctival autografting in pterygium surgery: a prospective comparative study
    A Karalezli
    Department of Ophthalmology, Baskent University School of Medicine, Ankara, Turkey
    Br J Ophthalmol 92:1206-10. 2008
    To compare the use of fibrin glue versus sutures for fixating conjunctival autografts in patients undergoing pterygium excision.
  45. ncbi Comparison of fibrin glue with sutures for pterygium excision surgery with conjunctival autografts
    Reece C Hall
    Ophthalmology Department, Wellington Hospital, Capital Coast District Health Board, Wellington, New Zealand
    Clin Experiment Ophthalmol 37:584-9. 2009
    To compare pterygium excision conjunctival autograft surgery using Tisseel fibrin glue versus Vicryl sutures.
  46. ncbi Cosmetic outcome of scalp wound closure with staples in the pediatric emergency department: a prospective, randomized trial
    Abu N G A Khan
    Department of Pediatrics, Babies Hospital, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Pediatr Emerg Care 18:171-3. 2002
    The purpose of this study is to compare the cosmetic outcome of scalp wound closure with staples to traditional skin sutures.
  47. pmc A single-surgeon randomized trial comparing sutures, N-butyl-2-cyanoacrylate and human fibrin glue for mesh fixation during primary inguinal hernia repair
    Mario Testini
    Section of General Surgery, Department of Applications in Surgery of Innovative Technologies, University Medical School of Bari, Italy
    Can J Surg 53:155-60. 2010
    We sought to determine the efficacy of sutures, human fibrin glue and N-butyl-2-cyanoacrylate for mesh fixation in patients undergoing the plug and mesh procedure for groin hernia.
  48. ncbi [Clinical and histopathological study of tissue reactivity to monofilament suture materials: nylon and poliglecaprone 25 in rats]
    Camila Maria Beder Ribeiro
    Universidade Federal de Pernambuco, Recife, PE, Brazil
    Acta Cir Bras 20:284-91. 2005
    The aim of this experimental study was to evaluate through a clinical and histopathological analysis the tissue reactivity caused by two monofilament sutures nylon and poliglecaprone 25 on the internal and external sutures in rats.
  49. ncbi A randomized study comparing skin closure in cesarean sections: staples vs subcuticular sutures
    Julie Anne Rousseau
    Department of Obstetrics and Gynecology, Laval University, Quebec, QC, Canada
    Am J Obstet Gynecol 200:265.e1-4. 2009
    We sought to compare postoperative pain according to the skin closure method (subcuticular sutures vs staples) after an elective term cesarean section.
  50. ncbi In vitro attachment of Staphylococcus epidermidis to surgical sutures with and without Ag-containing bioactive glass coating
    Jonathan Pratten
    Division of Infection and Immunity, Eastman Dental Institute for Oral Health Care Sciences, University College London, 256 Gray s Inn Road, WC1X 8LD, UK
    J Biomater Appl 19:47-57. 2004
    The ability of a silver-doped bioactive glass (AgBG) coating to prevent bacterial colonization on surgical sutures was investigated in vitro...
  51. ncbi Laparoscopic gastrointestinal anastomoses using knotless barbed sutures are safe and reproducible: a single-center experience with 201 patients
    Olivier Facy
    Department of Digestive Surgery, University Hospital of Luxembourg, Luxembourg, Luxembourg
    Surg Endosc 27:3841-5. 2013
    Intestinal anastomosis is a complex procedure during laparoscopy, mainly due to the difficulties knotting the sutures. Unidirectional barbed sutures have been proposed to simplify wall and mesentery closure, but the results for ..
  52. pmc Tension of knotted surgical sutures shows tissue specific rapid loss in a rodent model
    Christian D Klink
    Department of Surgery, RWTH Aachen, Germany
    BMC Surg 11:36. 2011
    ..The aim of this study was to identify the dynamic change of applied suture tension with regard to the tissue specific cutting reaction...
  53. ncbi Expansive open-door laminoplasty with titanium miniplate versus sutures
    Guangdong Chen
    Department of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China
    Orthopedics 35:e543-8. 2012
    ..Both surgical protocols were effective in preventing reclosure of open laminae. Furthermore, the modified laminoplasty was superior in reducing the incidence of axial symptoms and loss of cervical lordosis and range of motion...
  54. pmc Triclosan-coated sutures do not reduce leg wound infections after coronary artery bypass grafting
    Bjørn Edvard Seim
    Department of Cardiothoracic Surgery, Oslo University Hospital, Ullevaal, Oslo, Norway
    Interact Cardiovasc Thorac Surg 15:411-5. 2012
    ..The first aim of the present study was to compare Vicryl Plus with conventional Vicryl(®) sutures with regard to leg wound infections following CABG...
  55. ncbi Capillary activity of surgical sutures and suture-dependent bacterial transport: a qualitative study
    Dieter Geiger
    Surgical Clinic I, University Hospital of Wurzburg, Wurzburg, Germany
    Surg Infect (Larchmt) 6:377-83. 2005
    To evaluate the multitude of new synthetic absorbable sutures (both monofilament and multifilament) in comparison with older materials with regard to capillarity and bacterial transport.
  56. pmc Do absorbable sutures exacerbate presternal scarring?
    Suat Durkaya
    Department of Thoracic Surgery, Cumhuriyet University Hospital, Sivas, Turkey
    Tex Heart Inst J 32:544-8. 2005
    ..In group A, the upper half of the skin was closed with absorbable 4-0 braided polyglycolic acid sutures (Sentesorb, Boz; Ankara, Turkey), and the lower half was closed with 4-0 nonabsorbable monofilamentous ..
  57. ncbi Transscleral fixation of foldable intraocular lenses
    Suleyman Kaynak
    Department of Ophthalmology, Dokuz Eylul University School of Medicine, 1388 sok No 16 A, Alsancak, Izmir, Turkey
    J Cataract Refract Surg 30:854-7. 2004
    ..To report the results of transscleral implantation of foldable intraocular lenses (IOLs)...
  58. ncbi Primary flexor tendon repair--operative repair, pulley management and rehabilitation
    David Elliot
    Hand Surgery Department, St Andrew s Centre for Plastic Surgery, Broomfield Hospital, Chelmsford, Essex, UK
    J Hand Surg Br 27:507-13. 2002
  59. ncbi [Clinical experience in using a metallic suture in eye microsurgery]
    Dushin N V Kumar Vinod
    Vestn Oftalmol 119:16-20. 2003
    ..58% of cases (31 patients). The mean postoperative astigmatism was, 3 months after surgery, 1.65 diopters. The sutures were removed in 132 cases (10...
  60. ncbi Bridging short nerve defects by direct repair under tension, nerve grafts or longitudinal sutures
    Peter Scherman
    Department of Hand Surgery, Malmo University Hospital, Malmo, Sweden
    Restor Neurol Neurosci 22:65-72. 2004
    ..To compare the longitudinal suture model for bridging nerve defects with direct approximation under tension or with autologuos nerve grafting...
  61. ncbi Handling characteristics of poly(L-lactide-co-epsilon-caprolactone) monofilament suture
    Kenji Tomihata
    R and D Department, GUNZE Ltd, 1 Ishiburo, Ayabe, Kyoto 623 8513, Japan
    Biomed Mater Eng 15:381-91. 2005
    ..Six types of other monofilament sutures were also examined for comparisons. Two of these were nonabsorbable, while the others were absorbable sutures...
  62. ncbi Flap and suture manipulation after trabeculectomy with adjustable sutures: titration of flow and intraocular pressure in guarded filtration surgery
    Anthony P Wells
    Wound Healing Research Unit, Institute of Ophthalmology and Moorfields Eye Hospital, London
    J Glaucoma 13:400-6. 2004
    ..To describe the intraocular pressure (IOP) changes resulting from scleral flap suture and scleral flap manipulation in an experimental model of conventional guarded filtration surgery...
  63. ncbi Pharyngocutaneous fistulae following total laryngectomy comparison between manual and mechanical sutures
    Antonio Jose Gonçalves
    Head and Neck Division, Department of Surgery, Santa Casa Medical School, Sao Paulo, SP, Brazil
    Eur Arch Otorhinolaryngol 266:1793-8. 2009
    ..the incidence of pharingocutaneous salivary fistulae after total laryngectomies comparing manual and mechanical sutures. The study is designed as non-randomized, prospective clinical study...
  64. ncbi The application of the V-Loc closure device for gastrointestinal sutures: a preliminary study
    Elena Nemecek
    Department for Orthopaedics and Orthopaedic Surgery, Medical University of Vienna, Waehringer Guertel 18 20, 1090, Vienna, Austria
    Surg Endosc 27:3830-4. 2013
    Leakage is one of the major complications in gastrointestinal surgery. This preliminary study compared a new barbed absorbable thread for gastrointestinal sutures with monofil suture material in a cadaver model.
  65. ncbi Cyclic loading of rotator cuff repairs: an in vitro biomechanical comparison of bioabsorbable tacks with transosseous sutures
    Ryan T Bicknell
    Department of Surgery, University of Western Ontario, London, Ontario, Canada
    Arthroscopy 21:875-80. 2005
    ..compares rotator cuff repair strength after cyclic loading of bioabsorbable tacks and traditional transosseous sutures, and correlates the results with bone density, age, and gender...
  66. ncbi Lichtenstein inguinal herniorrhaphy using sutures versus tacks
    J M Douglas
    Washington Hospital Center, Washington, DC, USA
    Hernia 6:99-101. 2002
    ..Using the tacker on open inguinal hernia repairs shortens the time for mesh placement compared to suture fixation. Decreased operative time may reduce overall cost...
  67. ncbi Absence of circulating aldosterone attenuates foreign body reaction around surgical sutures
    Uwe Klinge
    Surgical Department, University Hospital of the RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany
    Langenbecks Arch Surg 395:429-35. 2010
    ..Mineralocorticoids like aldosterone have a pro-fibrotic and pro-inflammatory impact; thus, reduction of circulating aldosterone should result in an attenuated inflammatory response to implanted foreign bodies...
  68. ncbi Use of a novel absorbable barbed plastic surgical suture enables a "self-cinching" technique of vesicourethral anastomosis during robot-assisted prostatectomy and improves anastomotic times
    Ashutosh K Tewari
    LeFrak Center of Robotic Surgery and Institute of Prostate Cancer, James Buchanan Brady Foundation, Department of Urology, Weill Cornell Medical College, New York Presbyterian Hospital, New York, New York 10065, USA
    J Endourol 24:1645-50. 2010
    ..To demonstrate a novel technique of self-cinching anastomosis using a barbed and looped suture during robot-assisted radical prostatectomy (RARP)...
  69. ncbi Triclosan-coated sutures reduce wound infections after hepatobiliary surgery--a prospective non-randomized clinical pathway driven study
    Christoph Justinger
    Department of General, Visceral, Vascular and Pediatric Surgery, University of Saarland, 66421 Homburg Saar, Germany
    Langenbecks Arch Surg 396:845-50. 2011
    ..To reduce bacterial adherence to surgical sutures, triclosan-coated polyglactin 910 suture materials with antiseptic activity (Vicryl plus®) were developed...
  70. ncbi Surgical-site infection after abdominal wall closure with triclosan-impregnated polydioxanone sutures: results of a randomized clinical pathway facilitated trial (NCT00998907)
    Christoph Justinger
    Department of General and Visceral Surgery, Stadtisches Klinikum Karlsruhe, Karlsruhe, Germany
    Surgery 154:589-95. 2013
    ..We here report a prospective randomized pathway controlled trial investigating the effect of triclosan impregnation of polydioxanone sutures used for abdominal wall closure on the rate of surgical-site infections.
  71. ncbi Retrograde placement of ureteral stent and ureteropelvic anastomosis with two running sutures in transperitoneal laparoscopic pyeloplasty: tips of success in our learning curve
    Rocco Papalia
    Regina Elena National Cancer Institute, Rome, Italy
    J Endourol 23:847-52. 2009
    ....
  72. ncbi New anti-infective coatings of surgical sutures based on a combination of antiseptics and fatty acids
    F D Matl
    Institute of Medical Engineering, Technische Universitat Munchen, Boltzmannstrasse 11, 85748 Garching, Germany
    J Biomater Sci Polym Ed 20:1439-49. 2009
    ..The aim of this study was to develop new anti-infective coatings of surgical sutures and to compare the anti-microbial effectiveness and biocompatibility to the well-established Vicryl Plus...
  73. ncbi Tensile forces on sutures in the human lateral knee meniscus
    Christian Staerke
    Department of Orthopaedic Surgery, Otto von Guericke University Magdeburg, Leipziger Strasse 44, Magdeburg 39120, Germany
    Knee Surg Sports Traumatol Arthrosc 17:1354-9. 2009
    ..Forces other than tension and biological factors are of greater importance for the healing. Therefore, the assessment of repair techniques should not be based on alone the ability to resist high distraction forces...
  74. ncbi The hydrolytic degradation of polydioxanone (PDSII) sutures. Part II: Micromechanisms of deformation
    Chui Ping Ooi
    Department of Materials Science and Metallurgy, University of Cambridge, New Museums Site, Pembroke Street, Cambridge CB2 3QZ
    J Biomed Mater Res 63:291-8. 2002
    An investigation of morphological changes in hydrolytically degraded polydioxanone sutures (PDSII) during in situ tensile deformation is reported...
  75. ncbi Diagnostic significance of characteristic findings on ultrasonography for the stitch abscess after surgery in patients with oral squamous cell carcinoma
    Noriaki Yamamoto
    Department of Oral and Maxillofacial Surgery, Kyushu Dental College, Kitakyushu, Japan
    Oral Oncol 47:163-9. 2011
    ..Our results suggest that ultrasonography may be a very useful tool for diagnosis of postoperative stitch abscess and may help improve the quality of life of oral SCC patients...
  76. ncbi Long-term outcomes with transfascial sutures versus tacks in laparoscopic ventral hernia repair: a review
    Jason B Brill
    Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Am Surg 77:458-65. 2011
    Although most surgeons report using both transfascial sutures and laparoscopically placed tacks to secure prostheses in laparoscopic ventral hernia repair, a significant minority have reported large series in which sutures were omitted...
  77. ncbi A randomized controlled trial of high-viscosity 2-octyl cyanoacrylate tissue adhesive versus sutures in repairing facial wounds following Mohs micrographic surgery
    Patrick J Sniezek
    Department of Dermatology, University of Iowa Hospitals and Clinics, Iowa City, Iowa 50266, USA
    Dermatol Surg 33:966-71. 2007
    ..Use of HVOCA in repair of facial wounds after Mohs micrographic surgery (MMS) has not been reported...
  78. ncbi Barbed sutures: a review of the literature
    Mark T Villa
    Section of Plastic and Reconstructive Surgery, University of Chicago, IL, USA
    Plast Reconstr Surg 121:102e-108e. 2008
    ..The authors review the literature to estimate several clinical parameters pertaining to barbed thread suspensions...
  79. ncbi Laparoscopic transabdominal suspension sutures
    G Navarra
    Surg Endosc 16:1378; author reply 1379. 2002
  80. ncbi Antimicrobial sutures and prevention of surgical site infection: assessment of the safety of the antiseptic triclosan
    David Leaper
    Department of Dermatology and Wound Healing, Cardiff University, Cardiff, UK
    Int Wound J 8:556-66. 2011
    ..the uses of triclosan with demonstrable health benefits, as in some medical applications (such as antimicrobial sutures), need to be distinguished from those where there is no proven benefit, such as its use in certain consumer ..
  81. ncbi Local administration of TGF-beta1 to reinforce the anterior abdominal wall in a rat model of incisional hernia
    M Korenkov
    Surgical Clinic, Department of Surgery, University of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
    Hernia 9:252-8. 2005
    ..1 (4.2-9.1 N)). These results correlated with the gene expression of collagen I and III. Local application of TGF-beta(1) did not augment the strength of the abdominal wall after 6 weeks...
  82. ncbi [Fascial healing and wound failure]
    V Fackeldey
    Chirurgische Universitäts und Poliklinik, RWTH Aachen
    Chirurg 75:477-83. 2004
    ..New aspects of pharmacotherapy and better understanding of collagen synthesis and dynamics of closure tension might improve the clinical situation in the future...
  83. ncbi Minimum number of throws needed for knot security
    Tyler M Muffly
    Center for Urogynecology and Reconstructive Pelvic Surgery, Obstetrics, Gynecology and Women s Health Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Surg Educ 68:130-3. 2011
    ..The purpose of the study was to determine the optimal number of throws to ensure knot security...
  84. ncbi The role of multiple strands and locking sutures on gap formation of flexor tendon repairs during cyclical loading
    K A Barrie
    Yale Hand and Upper Extremity Center, Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, CT, USA
    J Hand Surg Am 25:714-20. 2000
    ..Locking of the repair does provide additional gap resistance at the relatively low cyclical loads anticipated during the early healing period using an active motion rehabilitation protocol...
  85. ncbi Polymeric meshes for internal sutures with differentiated adhesion on the two sides
    A Sannino
    Department of Engineering for the Innovation, University of Lecce, Lecce, Italy
    J Mater Sci Mater Med 16:289-96. 2005
    ..Cells seeded on the ammonia plasma treated material showed a better adhesion and spreading when compared to the untreated material...
  86. pmc Comparison of genome-wide gene expression in suture- and alkali burn-induced murine corneal neovascularization
    Changkai Jia
    Shandong Provincial Key Lab of Ophthalmology, Shandong Eye Institute, Shandong Academy of Medical Sciences, Qingdao, China
    Mol Vis 17:2386-99. 2011
    ..This study compares the changes in genome-wide gene expression under these two CorNV conditions in mice...
  87. ncbi Microbial keratitis after penetrating keratoplasty: impact of sutures
    Sonia Moorthy
    Royal Victorian Eye and Ear Hospital, Centre for Eye Research Australia, University of Melbourne, Victoria, Australia
    Am J Ophthalmol 152:189-194.e2. 2011
    To determine the impact of presence or absence of sutures in cases with post-penetrating keratoplasty (PKP) microbial keratitis.
  88. ncbi Lifting and wound closure with barbed sutures
    R Stephen Mulholland
    SpaMedica Clinics, 66 Avenue Road, Suite 4, Toronto, ON M5R 3N8, Canada
    Clin Plast Surg 38:521-35, viii. 2011
    The advent of barbed sutures has been a novel and useful adjunct for the aesthetic plastic surgeon in properly selected patients...
  89. ncbi New sutures and suture anchors in sports medicine
    F Alan Barber
    Plano Orthopedic and Sports Medicine Center, 5228 West Plano Parkway, Plano, TX 75093, USA
    Sports Med Arthrosc 14:177-84. 2006
    ..As companions to these biodegradable suture anchors, new sutures have been developed which possess greater strength and different material properties from the conventional ..
  90. ncbi An expanded surgical suture and needle evaluation and selection program by a healthcare resource management group purchasing organization
    Robin R Szarmach
    Consorta, Inc, Rolling Meadows, IL 60008, USA
    J Long Term Eff Med Implants 13:155-70. 2003
    ..healthcare resource management and group purchasing organization, and United States Surgical/Davis & Geck Sutures (Division of United States Surgical, Norwalk, Connecticut)...
  91. ncbi Staples or sutures for chest and leg wounds following cardiovascular surgery
    Aliu Sanni
    Department of Cardiothoracic Surgery, James Cook University Hospital, Middlesbrough, UK
    Interact Cardiovasc Thorac Surg 6:243-6. 2007
    ..The question asked was whether the use of skin sutures or skin staples for chest and leg wounds in patients following cardiovascular surgery reduces the incidence of ..
  92. ncbi Scientific basis for the selection of surgical staples and tissue adhesives for closure of skin wounds
    Richard F Edlich
    Biomedical Engineering and Emergency Medicine, University of Virginia Health System, Charlottesville, VA, USA
    J Environ Pathol Toxicol Oncol 29:327-37. 2010
    ..The revolutionary Insorb™ subcuticular skin stapler is designed to combine the cosmetic result of absorbable sutures with the rapid closure times associated with metal skin staplers, while eliminating the need for metal staple ..
  93. ncbi A novel method of urethrovesical anastomosis during robot-assisted radical prostatectomy using a unidirectional barbed wound closure device: feasibility study and early outcomes in 51 patients
    Sanjeev Kaul
    Vattikuti Urology Institute, Henry Ford Health System, Detroit, Michigan, USA
    J Endourol 24:1789-93. 2010
    ..To describe the safety and feasibility of a running urethrovesical anastomosis (UVA) in robot-assisted radical prostatectomy (RARP) using a unidirectional self-locking barbed suture...
  94. ncbi Comparison of a new multifilament stainless steel suture with frequently used sutures for flexor tendon repair
    Erik McDonald
    UCSF SFGH Orthopaedic Trauma Institute, and the Department of Anatomy and Orthopaedic Surgery, University of California, San Francisco, CA, USA
    J Hand Surg Am 36:1028-34. 2011
    ..To investigate the mechanical properties of some common suture materials currently in use and compare them with a new multifilament stainless steel suture...
  95. ncbi Bacterial adherence to cotton and silk sutures
    N Ananthakrishnan
    Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India
    Natl Med J India 5:217-8. 1992
    BACKGROUND. Silk and cotton sutures are the most commonly used materials for skin closure, the choice being largely based on tradition...
  96. ncbi Comparative study of "staples versus sutures" in skin closure following Dupuytren's surgery
    R Bhatia
    Department of Trauma and Orthopaedics, Royal Gwent Hospital, Newport, South Wales, UK
    J Hand Surg Br 27:53-4. 2002
    ..Although staples were significantly quicker to insert than sutures, patients experienced significantly more pain on removal of staples...
  97. pmc Laparoscopic removal of abdominal cerclage
    James F Carter
    Department of Obstetrics and Gynecology, Medical University of South Carolina, 96 Jonathan Lucas Street, Charleston, SC 29425, USA
    JSLS 11:375-7. 2007
    ..This minimally invasive surgical technique eliminates the need for laparotomy in response to a poor pre-viable pregnancy outcome...
  98. pmc Reducing blood loss in open radical retropubic prostatectomy with prophylactic periprostatic sutures
    Gustavo F Carvalhal
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    BJU Int 105:1650-3. 2010
    To determine whether the placement of small-calibre, rapidly absorbed prophylactic periprostatic sutures before the mobilization of the prostate could reduce blood loss during open retropubic radical prostatectomy (RRP).
  99. pmc Laparoscopic removal of abdominal cervical suture
    Mark McComiskey
    Ulster Med J 75:228. 2006
  100. ncbi Influence of suture technique on laparotomy wound healing: an experimental study in the rat
    J Hoer
    Surgical University Hospital RWTH Aachen, Germany
    Langenbecks Arch Surg 386:218-23. 2001
    ..In 50 rats, the musculo-fascial layer of median laparotomies was closed with polypropylene sutures using SLWL ratios of 8:1, 4:1, 2:1 and 1.7:1...
  101. ncbi Tissue response to the implantation of biodegradable polyhydroxyalkanoate sutures
    E I Shishatskaya
    Institute of Biophysics of the Siberian Branch of the Russian Academy of Sciences, Akademgorodok, Krasnoyarsk 660036, Russia
    J Mater Sci Mater Med 15:719-28. 2004
    Polyhydroxyalkanoate (PHA) sutures were implanted to test animals intramuscularly, and tissue reaction was investigated and compared with the reaction to silk and catgut...

Research Grants66

  1. Sutureless Laparoscopic Partial Nephrectomy Using Laser Tissue Welding: Preclinic
    Yasmin Wadia; Fiscal Year: 2013
    ..urethral stricture, urethral diverticulum, and urethral fistulae and all surgical procedures that currently use sutures. PUBLIC HEALTH RELEVANCE: The current proposal aims at Nephron Sparing surgery of small renal lesions...
  2. Clinical Development of Hemostatic Agent ClotFoam for Severe Hemorrhage
    Maja Nowakowski; Fiscal Year: 2013
    ..Blood Institute have compared the hemostastic effect of ClotFoam against GelFoam (Pfizer), without compression or sutures in three surgical protocols producing moderated to severe venous and arterial bleeding...
  3. Mechanisms of FGFR2 Signaling in Craniofacial Development
    Veraragavan P Eswarakumar; Fiscal Year: 2013
    ..Jackson-Weiss, Seathre Chotzen and Apert syndrome which are characterized by the premature fusion of cranial sutures before the completion of brain growth...
  4. PHENOGENETICS OF SKULL AND BRAIN INTEGRATION IN CRANIOSYNOSTOSIS
    JOAN THERESE RICHTSMEIER; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Craniosynostosis, the premature fusion of one or more cranial sutures, is a common malformation occurring in 1 out of every 2500 live births and shows marked variation of phenotypes...
  5. "Gdf6 gene expression and evolution in vertebrates"
    Douglas Mortlock; Fiscal Year: 2009
    ..novel long-range genomic regulatory elements controlling Gdf6 expression in developing limb joints, skull sutures, jaw and ear bones, and laryngeal structures...
  6. Risk Factors for Craniosynostosis
    Suzan L Carmichael; Fiscal Year: 2010
    SUMMARY/ABSTRACT Craniosynostosis (CS) refers to the premature fusion of one or more of the cranial sutures, leading to abnormal cranial and facial shapes and function...
  7. SINGLE SUTURE CRANIOSYNOSTOSIS: CANDIDATE GENE AND PATHWAY DISCOVERY
    Michael L Cunningham; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Craniosynostosis is the pathologic fusion of the sutures of the calvaria. It is associated with significant morbidity, occasional mortality, and carries a considerable financial burden...
  8. Electromechanical reshaping of tissue
    Brian Wong; Fiscal Year: 2010
    ..by applicant): For more than a century, surgeons have envisioned reshaping tissue without the use of scalpels and sutures. Recently, developments with multiple therapeutic modalities have brought this vision closer to reality through ..
  9. Nell-1, A Cbfa 1 Downstream Target, In Bone Formation
    Kang Ting; Fiscal Year: 2009
    ..strongly expressed in neural tissue encoding epidermal growth factor (EGF)-like domain] from prematurely fusing sutures in craniosynostosis (CS) patients (Many of these studies were performed before identification of the short Nell-1,..
  10. Screen for mutations affecting skull and suture formation in zebrafish
    Shannon Fisher; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The closure of cranial sutures is a key process during skull morphogenesis. At the edges of the flat bones, which are centers of regulated bone formation, fibrous sutures unite the individual bones...
  11. 2012 Craniofacial Morphogenesis &Tissue Regeneration GRS &GRC
    Robert E Maxson; Fiscal Year: 2012
    ..Non-syndromic disorders that affect the cranial sutures, palate, teeth and jaw are also common...
  12. Tear-Resistant and Elastic Tissue Adhesive for Craniofacial Applications
    SILVIA D LUEBBEN; Fiscal Year: 2012
    ..these adhesives cannot be used to repair deep dermal cuts or to close wounds that are under tensions unless sutures and/or immobilization are also used...
  13. The regulatory role of Bone morphogenetic protein 1 in suture patency and fusion
    Matthew Harris; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The correct patterning and timing of the fusion of cranial sutures is essential for normal skull development...
  14. Mechanism and Prevention of Female Stress Urinary Incontinence
    Tom F Lue; Fiscal Year: 2013
    ..or medical option for stress urinary incontinence (SUI) other than surgical elevation of the urethra with sutures or a synthetic sling...
  15. Midface and Upper Airway in Craniosynostosis
    JOAN THERESE RICHTSMEIER; Fiscal Year: 2013
    ..of craniosynostosis which detail precise aspects of the cranial vault, cranial base, facial skeleton, facial sutures, and upper airway that are differentially affected by various FGFR2 and FGFR3 mutations...
  16. Cranial suture formation in the zebrafish
    Shannon Fisher; Fiscal Year: 2012
    ..test the hypothesis that a transient population of neural crest cells play an important role in patterning the sutures by determining the dynamic contribution of neural crest to the sutures and skull bones, using genetic labeling to ..
  17. Tissue Engineering a Suture Replacement for Children with Craniosynostosis
    Gregory M Cooper; Fiscal Year: 2012
    ..provided by applicant): Craniosynostosis is defined as the premature fusion of one or more of the cranial sutures. Current therapy involves extensive surgical intervention including fronto-orbital advancement and radical ..
  18. Characterization of the interplay between SEC23A and the MAPK signaling pathway
    Jinoh Kim; Fiscal Year: 2013
    ..receptor (FGFR), accounts for most cases of familial craniosynostosis (CS), the premature fusion of the cranial sutures. Lessening this aberrant MAPK signaling by an inhibitor of this pathway was sufficient to rescue CS phenotypes in ..
  19. Dynamic changes in the chick developing heart in response to altered hemodynamics
    Sandra Rugonyi; Fiscal Year: 2013
    ..interventions that change blood pressure and shear stresses by constricting or ligating vessels with surgical sutures. Aims are: Aim 1: Determine early changes in mechanical stimuli in response to hemodynamic interventions...
  20. Anti-fibrotic Coatings for Rapidly Exchangeable Bioprosthetic Heart Valve
    Ivan Vesely; Fiscal Year: 2010
    ..This allows the surgeon to place sutures more conveniently, without risk of damaging the leaflet core...
  21. Feasibility of Supercritical Carbon Dioxide Sterilization for Absorbable Suture M
    JANET L HUIE; Fiscal Year: 2013
    ..scCO2) sterilization technology that have no adverse effects on the mechanical properties and no cytotoxicity of sutures sterilized to SAL6 under ISO guidelines...
  22. Secondary Analysis of Four Trichiasis Surgery Clinical Trials to Inform Managemen
    Emily W Gower; Fiscal Year: 2013
    ..These completed trials include the NEI-funded STAR trial, PRET surgery, absorbable vs. silk sutures, and surgery vs. epilation. Data elements collected are mostly the same for each trial...
  23. GENETIC REGULATORY NETWORK IN CRANIOFACIAL DEVELOPMENT
    Wei Hsu; Fiscal Year: 2013
    ..During development of the calvarium, cranial sutures serve as growth centers for skeletogenesis...
  24. Laser Activated Ophthalmic Adhesive
    Barbara Soltz; Fiscal Year: 2009
    ..Millions of ophthalmic procedures are performed annually, most incorporating sutures to close and seal wounds...
  25. Bioadhesive Membrane Construct for Hernia Repair
    NEIL WINTERBOTTOM; Fiscal Year: 2010
    ..Currently, sutures, staples, or tacks are used to fixate synthetic and biologic meshes in place, but these methods can be a source ..
  26. Controlling the Mechanobiology of Cutaneous Wounds to Reduce Hypertrophic Scar
    Edward A Sander; Fiscal Year: 2013
    ..g. stress shielding sheets, shape memory sutures, sutures with elastic gradients, and adhesives), many important variables are not optimally defined...
  27. Molecular pathogenesis of craniosynostosis caused by enhanced BMP signaling
    Yuji Mishina; Fiscal Year: 2013
    ..Our study will further define molecular pathways directly involves in pathogenesis of premature fusion of cranial sutures leading to craniosynostosis, and will therefore provide better insights for potential molecular targets for ..
  28. Development of Infection-Resistant Suture Materials
    Matthew Phaneuf; Fiscal Year: 2004
    ..The inherent bulk properties of various biomaterials, including those that comprise sutures, provide a milieu for initial bacterial adhesion with subsequent biofilm production and growth...
  29. Growth Factor Coated Sutures for Improved Tendon Repair
    HANNE GRON; Fiscal Year: 2010
    ..Here we propose the manufacture of a peptide-based coating, permitting the loading of these growth factors to the sutures used during surgical repair of tendon tissue to promote their sustained release...
  30. Biological sutures to enhance progenitor cell delivery and retention in the heart
    Glenn R Gaudette; Fiscal Year: 2013
    ..Development of this innovative technology will improve cell delivery to the heart while providing targeted delivery and concise placement of cells in the region of interest. ..
  31. Development of Infection-Resistant Suture Materials
    Matthew Phaneuf; Fiscal Year: 2007
    ..The inherent bulk properties of various biomaterials, including those that comprise sutures, provide a milieu for initial bacterial adhesion with subsequent biofilm production and growth...
  32. Biomimetic Tissue Adhesive with Mechanically Tough Hydrogel Support
    Bruce P Lee; Fiscal Year: 2013
    ..While, the discontinuity in soft tissues is traditionally secured with mechanical perforating devices (e.g., sutures, tacks, and staples), these devices are also a source of complications, such as tissue trauma, chronic pain and ..
  33. REGULATION OF CRANIALSUTURE MORPHOGENESIS
    Roy Ogle; Fiscal Year: 2002
    DESCRIPTION (Adapted from the Applicant's Abstract): Premature fusion of the cranial sutures is the primary cause of many severe craniofacial abnormalities...
  34. Biomedical adhesives with precisely engineered surface topography and chemistry
    JEFFREY MICHAEL KARP; Fiscal Year: 2013
    ..Potential benefits include reduction in operating time, tissue handling, and mitigation of surgical complications such as infection by eliminating the need for sutures.
  35. Cell dynamics in calvarial morphogenesis
    Jacqui Tabler; Fiscal Year: 2012
    Craniosynostosis is the debilitating precocious ossification of cranial sutures, the fibrous joints between skull bones...
  36. Repair of Focal Defects in the Annulus Fibrosus Using Injectable High-Density Col
    BRANDON BORDE; Fiscal Year: 2013
    ..In order to return some function to the disc, several defect closure methods have been developed, such as sutures and barriers, which provide mechanical support for the defect but do not promote biological healing...
  37. Surgical Adhesive for Seroma Prevention
    CHAD COBERLY; Fiscal Year: 2013
    ..Traditional wound closure approaches such as sutures provide point-to- point fixation, which is inadequate to fully adhere planar surfaces...
  38. Mechanistic Role of NELL-1 in Premature Suture Closure
    Kang Ting; Fiscal Year: 2003
    ..demonstrate multiple cranial abnormalities including obliteration of ventricles, premature closure of cranial sutures, and deformities of cranial bones. CBFA1 has recently been shown to play an important role in FGFR1 induced CS...
  39. Convergent Molecular Evolution of Moth and Spider Silks
    NADIA AYOUB; Fiscal Year: 2009
    ..These artificial silks can then be used in biomedical applications, such as artificial ligaments or tendons and incredibly thin but strong sutures.
  40. Delayed Hydrogel Tissue Expander
    Yourong Fu; Fiscal Year: 2007
    ..Current self-inflating expanders expand immediately which may damage sutures related to the implantation wound...
  41. Compliant Shape Memory Polymer Device for Meniscal Repair
    KATHRYN ELIZABETH SMITH; Fiscal Year: 2011
    ..Fixation devices, such as sutures, tacks, and hybrid devices, are commonly used in meniscus repair procedures to help facilitate tissue healing...
  42. Bioswellable Absorbable Monofilament Sutures
    Shalaby W Shalaby; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Bioswellable Absorbable Monofilament Sutures Abstract Phase I study was intended and did demonstrate the feasibility of applying a new concept in macromolecular chain design to develop novel, ..
  43. CLINICAL EFFECTIVENESS OF LATE MAXILLARY PROTRACTION FOR CLEFT LIP AND PALATE
    Stephen L K Yen; Fiscal Year: 2013
    ..The early treatment, maxillary protraction, starts at age 13, is given at this time because the maxillary sutures have not fused yet and are amenable to manipulation...
  44. Scalable Purification of Silk-Like Proteins from Transgenic Tobacco
    WILLIAM MARCOTTE; Fiscal Year: 2007
    ..such as artificial tendons and ligaments, cell scaffolds for bone and cartilage implants, and biodegradable micro-sutures. Unlike silkworms, farming of spiders is unrealistic because of low silk yields and territorial behavior...
  45. Genetic and developmental pathways causing midface hypoplasia
    TIMOTHY CHILTON COX; Fiscal Year: 2013
    ..significant craniofacial anomalies and is characterized by the pathologic premature fusion of one or more cranial sutures, the regions of non-mineralized mesenchyme separating the cranial bones...
  46. Manufacturing Process for Albumin-ICG Solder & Denatured Albumin Scaffold
    Yasmin Wadia; Fiscal Year: 2006
    ..diverticulum, and urethral fistulae (600/yr) and skin approximation (all surgical procedures that currently use sutures) Relevance: 1) LTW will save lives due to its ability to quickly repair (minutes) and control hemorrhage from the ..
  47. Bioadhesive Membrane Construct to Augment Tendon Repair
    Ray Vanderby; Fiscal Year: 2012
    ..of a ruptured tendon, reinforcing traditional suture repair, and creating a repair that is stronger than with sutures alone...
  48. NOVEL CONCEPT FOR DEGRADATION OF ABSORBABLE POLYMERS
    Chih Chang Chu; Fiscal Year: 1990
    The specific aims of this pilot study is to use synthetic absorbable sutures (SAS) as the model compound to test the feasibility of a novel concept to control the biodegradation of synthetic absorbable polymers...
  49. Regulation of Cranial Suture Development by TGF-Beta and Fibroblast Growth Factor
    Arun Gosain; Fiscal Year: 2007
    ..suture calvaria, and 2) expression of these molecules in the fused PF suture in mice parallels that in fused sutures from human children with congenital craniosynostosis...
  50. THE EFFECT OF FIBRONECTIN ANTAGONISTS ON OSTEOGENESIS IN
    Amr Moursi; Fiscal Year: 2001
    ..are a group of congenital disorders which involve the premature fusion of one or more of the cranial sutures, causing cessation or distortion of cranial growth...
  51. DYSFUNCTIONAL FGFR SIGNALING IN CRANIOSYNOSTOSIS
    Robert Friesel; Fiscal Year: 2002
    Craniosynostosis, an abnormality of skull development in which the sutures of the growing calvarial bones fuse prematurely, occurs with a frequency of approximately 1 in 2500 live births...
  52. BONE GROWTH, PERIOSTEAL MIGRATION AND MUSCLE FUNCTION
    Susan Herring; Fiscal Year: 2007
    ..Moreover, forces generated by septal growth are claimed to separate the sutures between facial bones, causing compensatory growth. These assertions have never been tested directly...
  53. Durable Muscle-Prosthetic Bond for Artificial Tendons
    Natalia Juncosa Melvin; Fiscal Year: 2009
    ..greater loads, without pressure-damage to tissue, than can be transferred by the interlocking mechanism of sutures or staples. The resulting device is the OrthoCouplerTM...
  54. LOW-DOSE RADIATION STERILIZATION
    SHALABY SHALABY; Fiscal Year: 2000
    ..5 KGy) GR, and importance of PP and absorbable sutures justified pursuing the proposed study...
  55. Regulation of Mandibular Condylar Cartialage Growth
    Robert Hinton; Fiscal Year: 2006
    ..Relatively little is known of how the molecular determinants of growth differ among cranial sutures, mandibular condylar cartilage, and the cranial base cartilages...
  56. NONSYNDROMIC CRANIOSYNOSTOSIS: PHENOTYPE/GENOTYPE STUDY
    SIMEON A BOYADJIEV BOYD; Fiscal Year: 2010
    Craniosynostosis, the premature fusion of 1 or more cranial sutures is a common malformation occurring in 3 to 5 per 10,000 live births. Most often craniosynostosis occurs as an isolated (i.e. nonsyndromic) anomaly...
  57. Fibronectin Antagonists in Cranial Suture Formation
    Amr Moursi; Fiscal Year: 2006
    ..are a group of congenital disorders which involve the premature fusion of one or more of the cranial sutures, causing cessation or distortion of craniofacial growth...
  58. EVALUATION OF MEG AS A CURRENT SOURCE IMAGING TECHNIQUE
    Yoshio Okada; Fiscal Year: 2004
    ..e. in the area of human neonatal brain research. Unlike the adults, the skull of the infants has fontanels and sutures which may be abnormally large in pathological cases...
  59. GROWTH FACTOR REGULATION OF CRANIAL SUTURE MORPHOGENESIS
    LYNNE OPPERMAN; Fiscal Year: 2000
    ..craniofacial anomalies are associated with abnormal suture morphogenesis, and involve premature obliteration of sutures. Currently, the mechanisms underlying normal and abnormal suture morphogenesis are not known...
  60. MOLECULAR AND CELLULAR MECHANISMS OF CRANIOSYNOSTOSIS
    MICHAEL IGNELZI; Fiscal Year: 2000
    ..between the developing flat bones of the calvaria, the mesenchymal blastema of the presumptive cranial sutures, and the underlying dura mater...
  61. WOUND HEALING AFTER FETAL CLEFT LIP REPAIR
    Leonard Kaban; Fiscal Year: 1990
    ..A paramedian cleft is created on one side of the lip and either repaired (in a straight line with 8-0 nylon sutures under 6X loupe magnification) or left unrepaired...
  62. MOLECULAR GENETICS OF A SYNDROME WITH HEARING IMPAIRMENT
    J Post; Fiscal Year: 2004
    ..Crouzon craniofacial dysostosis (CFD), which is characterized by craniosynostosis (premature closure of calvarial sutures) and mapping CFD and delineating the entire structure of the mutated gene, FGFR2...
  63. A Shear Force Transfer Coupling for Soft Tissue Repair
    MARK BYRNE; Fiscal Year: 2003
    ..This is a distinctly different mechanism of action from conventional sutures and staples...
  64. LOW-DOSE RADIATION STERILIZATION
    SHALABY SHALABY; Fiscal Year: 2003
    ..I study and recent results demonstrated that (1) polypropylene (PP) monofilament and polyglycolide (PG) braided sutures can be sterilized by 5 and 7...
  65. MOLECULAR MECHANISMS OF CRANIAL SUTURE FUSION
    Michael Longaker; Fiscal Year: 2007
    ..We will study the molecular and cell biology regulating fusion of cranial sutures in mice...
  66. MECHANISMS OF FGF RESPONSES IN OSTEOGENIC CELLS
    Claudio Basilico; Fiscal Year: 2009
    ..of human bone morphogenetic disorders, including dwarfism and craniosynostosis (premature closure of cranial sutures) syndromes, by affecting the proliferation and differentiation of the two major cell types responsible for bone ..