implantable defibrillators

Summary

Summary: Implantable devices which continuously monitor the electrical activity of the heart and automatically detect and terminate ventricular tachycardia (TACHYCARDIA, VENTRICULAR) and VENTRICULAR FIBRILLATION. They consist of an impulse generator, batteries, and electrodes.

Top Publications

  1. ncbi ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: a report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Com
    Douglas P Zipes
    J Am Coll Cardiol 48:e247-346. 2006
  2. ncbi Long-term clinical course of patients after termination of ventricular tachyarrhythmia by an implanted defibrillator
    Arthur J Moss
    Cardiology Unit of the Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Circulation 110:3760-5. 2004
  3. ncbi Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure
    Gust H Bardy
    Seattle Institute for Cardiac Research, Seattle, WA 98103, USA
    N Engl J Med 352:225-37. 2005
  4. ncbi Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction
    Arthur J Moss
    Cardiology Unit of the Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA
    N Engl J Med 346:877-83. 2002
  5. ncbi Remote, wireless, ambulatory monitoring of implantable pacemakers, cardioverter defibrillators, and cardiac resynchronization therapy systems: analysis of a worldwide database
    Arnaud Lazarus
    InParys Clinical Research Group, Paris, France
    Pacing Clin Electrophysiol 30:S2-S12. 2007
  6. ncbi Rationale and design of a prospective study of the efficacy of a remote monitoring system used in implantable cardioverter defibrillator follow-up: the Lumos-T Reduces Routine Office Device Follow-Up Study (TRUST) study
    Niraj Varma
    Cardiac Electrophysiology Laboratory, Loyola University Medical Center, Maywood, IL 60153, USA
    Am Heart J 154:1029-34. 2007
  7. doi HRS/EHRA Expert Consensus on the Monitoring of Cardiovascular Implantable Electronic Devices (CIEDs): description of techniques, indications, personnel, frequency and ethical considerations: developed in partnership with the Heart Rhythm Society (HRS) and
    Bruce L Wilkoff
    Cleveland Clinic, Cleveland, Ohio, USA
    Europace 10:707-25. 2008
  8. ncbi Quality of life in the antiarrhythmics versus implantable defibrillators trial: impact of therapy and influence of adverse symptoms and defibrillator shocks
    Eleanor B Schron
    Clinical Trials Group, National Heart, Lung, and Blood Institute, Bethesda, MD, USA
    Circulation 105:589-94. 2002
  9. ncbi Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure
    Michael R Bristow
    Division of Cardiology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    N Engl J Med 350:2140-50. 2004
  10. ncbi Potential role of remote monitoring for scheduled and unscheduled evaluations of patients with an implantable defibrillator
    Hein Heidbuchel
    Department of Cardiology Electrophysiology, University Hospital Gasthuisberg, University of Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Europace 10:351-7. 2008

Detail Information

Publications278 found, 100 shown here

  1. ncbi ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: a report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Com
    Douglas P Zipes
    J Am Coll Cardiol 48:e247-346. 2006
  2. ncbi Long-term clinical course of patients after termination of ventricular tachyarrhythmia by an implanted defibrillator
    Arthur J Moss
    Cardiology Unit of the Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Circulation 110:3760-5. 2004
    ..This analysis from the MADIT-II trial database examines the long-term clinical course and subsequent mortality risk of patients after termination of life-threatening ventricular tachyarrhythmias by an ICD...
  3. ncbi Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure
    Gust H Bardy
    Seattle Institute for Cardiac Research, Seattle, WA 98103, USA
    N Engl J Med 352:225-37. 2005
    ..Treatment with amiodarone or an implantable cardioverter-defibrillator (ICD) has been proposed to improve the prognosis in such patients...
  4. ncbi Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction
    Arthur J Moss
    Cardiology Unit of the Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA
    N Engl J Med 346:877-83. 2002
    ..This randomized trial was designed to evaluate the effect of an implantable defibrillator on survival in such patients...
  5. ncbi Remote, wireless, ambulatory monitoring of implantable pacemakers, cardioverter defibrillators, and cardiac resynchronization therapy systems: analysis of a worldwide database
    Arnaud Lazarus
    InParys Clinical Research Group, Paris, France
    Pacing Clin Electrophysiol 30:S2-S12. 2007
    ..To describe the daily routine application of a new telemonitoring system in a large population of cardiac device recipients...
  6. ncbi Rationale and design of a prospective study of the efficacy of a remote monitoring system used in implantable cardioverter defibrillator follow-up: the Lumos-T Reduces Routine Office Device Follow-Up Study (TRUST) study
    Niraj Varma
    Cardiac Electrophysiology Laboratory, Loyola University Medical Center, Maywood, IL 60153, USA
    Am Heart J 154:1029-34. 2007
    ..All study patients will have a final office visit 15 months after implant. The results of TRUST may confirm the role of remote monitoring as an intensive surveillance mechanism for device management...
  7. doi HRS/EHRA Expert Consensus on the Monitoring of Cardiovascular Implantable Electronic Devices (CIEDs): description of techniques, indications, personnel, frequency and ethical considerations: developed in partnership with the Heart Rhythm Society (HRS) and
    Bruce L Wilkoff
    Cleveland Clinic, Cleveland, Ohio, USA
    Europace 10:707-25. 2008
  8. ncbi Quality of life in the antiarrhythmics versus implantable defibrillators trial: impact of therapy and influence of adverse symptoms and defibrillator shocks
    Eleanor B Schron
    Clinical Trials Group, National Heart, Lung, and Blood Institute, Bethesda, MD, USA
    Circulation 105:589-94. 2002
    ..However, the relative impact of these therapies on self-perceived quality of life (QoL) is unknown...
  9. ncbi Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure
    Michael R Bristow
    Division of Cardiology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    N Engl J Med 350:2140-50. 2004
    ....
  10. ncbi Potential role of remote monitoring for scheduled and unscheduled evaluations of patients with an implantable defibrillator
    Hein Heidbuchel
    Department of Cardiology Electrophysiology, University Hospital Gasthuisberg, University of Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Europace 10:351-7. 2008
    ..New technology allows for remote monitoring of device function. We wanted to investigate its potential reliability and to which extent its use can reduce in-office visits...
  11. pmc Prognostic importance of defibrillator shocks in patients with heart failure
    Jeanne E Poole
    Division of Cardiology, University of Washington School of Medicine, 1959 NE Pacific St, Box 356422, Seattle, WA 98195 6422, USA
    N Engl J Med 359:1009-17. 2008
    ..e., prevention of a first life-threatening arrhythmic event) may later receive therapeutic shocks from the ICD. Information about long-term prognosis after ICD therapy in such patients is limited...
  12. ncbi Home monitoring remote control of pacemaker and implantable cardioverter defibrillator patients in clinical practice: impact on medical management and health-care resource utilization
    Renato Pietro Ricci
    Department of Cardiovascular Disease, San Filippo Neri Hospital, Via Martinotti 20, 00135 Rome, Italy
    Europace 10:164-70. 2008
    ..To evaluate the impact of Home Monitoringtrade mark(HM) remote control on patient medical treatment and on health-care resource utilization...
  13. ncbi Potential role of home monitoring to reduce inappropriate shocks in implantable cardioverter-defibrillator patients due to lead failure
    Sebastian Spencker
    Division of Cardiology, Charite Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Europace 11:483-8. 2009
    ..We therefore analysed the data from the Biotronik HM system whether it enables physicians to react quickly on serious ICD malfunctions and to avoid inappropriate shocks...
  14. doi ACC/AHA/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the ACC/AHA/NASPE 2002 Guideline
    Andrew E Epstein
    Circulation 117:e350-408. 2008
  15. ncbi Prophylactic use of an implantable cardioverter-defibrillator after acute myocardial infarction
    Stefan H Hohnloser
    Department of Medicine, Division of Cardiology, J W Goethe University, Frankfurt, Germany
    N Engl J Med 351:2481-8. 2004
    ..Whether benefit occurs in patients early after myocardial infarction is unknown...
  16. ncbi Seasonal variation of mortality in the Antiarrhythmics Versus Implantable Defibrillators (AVID) study registry
    Richard L Page
    Department of Internal Medicine, Cardiology Division, University of Washington School of Medicine, Seattle, 98195, USA
    Heart Rhythm 1:435-40. 2004
    ..We postulated that the pattern of death would be nonrandom with respect to temporal variables...
  17. ncbi The high cost of implantable defibrillators
    Mark A Hlatky
    Stanford University School of Medicine, HRP Redwood Building, Room 150, Stanford, CA 94305 5405, USA
    Eur Heart J 28:388-91. 2007
    ..The cost-effectiveness of ICDs would be improved by development of simpler and cheaper devices, and by better tools to identify patients who benefit from an ICD...
  18. ncbi Electrical storm presages nonsudden death: the antiarrhythmics versus implantable defibrillators (AVID) trial
    D V Exner
    University of Calgary, Canada
    Circulation 103:2066-71. 2001
    ..However, insufficient data exist regarding its prognostic significance...
  19. ncbi Ambient air pollution and cardiac arrhythmias in patients with implantable defibrillators
    Kristina B Metzger
    Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
    Epidemiology 18:585-92. 2007
    ..Previous studies of ambient air pollution and ventricular tachyarrhythmias in patients with implantable cardioverter defibrillators have yielded mixed results...
  20. ncbi Ventricular arrhythmia storms in postinfarction patients with implantable defibrillators for primary prevention indications: a MADIT-II substudy
    Henry W Sesselberg
    Department of Medicine, Cardiology Unit, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Heart Rhythm 4:1395-402. 2007
    ..Much of prognostic implications of ventricular arrhythmia storms remain unclear...
  21. ncbi Pacemaker and ICD generator reliability: meta-analysis of device registries
    William H Maisel
    Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass 02215, USA
    JAMA 295:1929-34. 2006
    ..Despite there being millions of pacemaker and implantable cardioverter-defibrillator (ICD) generator implants worldwide, little is known about device reliability...
  22. pmc Remote monitoring of implantable cardioverter defibrillator patients: a safe, time-saving, and cost-effective means for follow-up
    M J Pekka Raatikainen
    Division of Cardiology, Department of Internal Medicine, University of Oulu, PO Box 5000, 90014 Oulu, Finland
    Europace 10:1145-51. 2008
    ....
  23. ncbi Clinical utility of intrathoracic impedance monitoring to alert patients with an implanted device of deteriorating chronic heart failure
    Dirk Vollmann
    Herzzentrum, Abteilung Kardiologie und Pneumologie, Klinikum der Georg August Universität, Robert Koch Strasse 40, 37075 Gottingen, Germany
    Eur Heart J 28:1835-40. 2007
    ..To evaluate the utility of intrathoracic impedance monitoring for detecting heart failure (HF) deterioration in patients with an implanted cardiac resynchronization/defibrillation device...
  24. ncbi Pacemaker and ICD generator malfunctions: analysis of Food and Drug Administration annual reports
    William H Maisel
    Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass 02215, USA
    JAMA 295:1901-6. 2006
    ..It is not known if increasing device complexity is associated with decreased reliability...
  25. ncbi Failure of impedance monitoring to prevent adverse clinical events caused by fracture of a recalled high-voltage implantable cardioverter-defibrillator lead
    Linda M Kallinen
    Minneapolis Heart Institute Foundation, Minneapolis, Minnesota, USA
    Heart Rhythm 5:775-9. 2008
    ..The Medtronic Sprint Fidelis implantable cardioverter-defibrillator high-voltage lead is prone to fracture. The October 2007 safety advisory recommended lead impedance monitoring to aid in identifying lead fractures...
  26. ncbi Implantable cardioverter/defibrillator therapy in arrhythmogenic right ventricular cardiomyopathy: single-center experience of long-term follow-up and complications in 60 patients
    Thomas Wichter
    Department of Cardiology and Angiology, University Hospital of Munster, Germany
    Circulation 109:1503-8. 2004
    ..We hypothesized that treatment with implantable cardioverter/defibrillators (ICDs) is safe and improves the long-term prognosis of ARVC patients at high risk of sudden death...
  27. ncbi Implantable cardioverter-defibrillator therapy for prevention of sudden death in patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia
    Domenico Corrado
    Divisione di Cardiologia e Patologia Cardiovascolare, Universita di Padova, Padova, Italy
    Circulation 108:3084-91. 2003
    ..Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is a condition associated with the risk of sudden death (SD)...
  28. ncbi Can monitoring of intrathoracic impedance reduce morbidity and mortality in patients with chronic heart failure? Rationale and design of the Diagnostic Outcome Trial in Heart Failure (DOT-HF)
    Frieder Braunschweig
    Karolinska Institutet, Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden
    Eur J Heart Fail 10:907-16. 2008
    ..Monitoring of intrathoracic impedance, measured from an implanted device, can detect increases in pulmonary fluid retention early and facilitate timely treatment interventions...
  29. ncbi Continuous autonomic assessment in patients with symptomatic heart failure: prognostic value of heart rate variability measured by an implanted cardiac resynchronization device
    Philip B Adamson
    Department of Medicine, Cardiovascular Disease and Physiology, University of Oklahoma Health Sciences Center, 920 SL Young Blvd, WP3120, Oklahoma City, OK 73104, USA
    Circulation 110:2389-94. 2004
    ..Long-term continuous HRV can be measured from an implantable device, but the clinical value of these measurements is unknown...
  30. ncbi Implantable cardioverter defibrillator recipients: quality of life in recipients with and without ICD shock delivery: a prospective study
    H C M Kamphuis
    Research Group Psychology of Health and Illness, University Medical Centre Utrecht, The Netherlands
    Europace 5:381-9. 2003
    ..In total 167 patients were monitored after discharge. Four self-administered questionnaires were used. The first assessment took place before ICD implantation, the remaining three at 1, 6 and 12 months after discharge...
  31. ncbi The Seattle Heart Failure Model: prediction of survival in heart failure
    Wayne C Levy
    University of Washington, Seattle, WA 98177, USA
    Circulation 113:1424-33. 2006
    ....
  32. ncbi Air pollution and cardiac arrhythmias in patients with implantable cardioverter defibrillators
    Sverre Vedal
    National Jewish Medical and Research Center, Denver, Colorado 80246, USA
    Inhal Toxicol 16:353-62. 2004
    ..They may be chance findings. Alternatively, given the very low concentrations of SO(2) that were present in Vancouver, SO(2) may have been serving as a surrogate measure of other environmental or meteorological factors...
  33. ncbi Combined cardiac resynchronization and implantable cardioversion defibrillation in advanced chronic heart failure: the MIRACLE ICD Trial
    James B Young
    Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    JAMA 289:2685-94. 2003
    ....
  34. pmc Maximum potential benefit of implantable defibrillators in preventing sudden death after hospital admission because of heart failure
    Soko Setoguchi
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02130, USA
    CMAJ 180:611-6. 2009
    b>Implantable defibrillators are recommended for the prevention of sudden cardiac death in patients with heart failure. However, criteria to identify those who would benefit most from this therapy are lacking...
  35. ncbi Psychosocial issues of patients with implantable cardioverter defibrillators
    Sandra B Dunbar
    Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA, USA
    Am J Crit Care 14:294-303. 2005
    ..Psychosocial issues, their ramifications, and theory-and evidence-based approaches to improving outcomes are described...
  36. ncbi Patient expectations from implantable defibrillators to prevent death in heart failure
    Garrick C Stewart
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Card Fail 16:106-13. 2010
    ..This study examined patient expectations from ICDs for primary prevention of sudden death in HF...
  37. ncbi Implantation of active can implantable defibrillators in the right pectoral region
    S M Jensen
    Department of Medicine B, Rigshospitalet, University of Copenhagen, Denmark
    Pacing Clin Electrophysiol 21:476-7. 1998
    ..The DFT was 12 J in two and 18 J in one patient. Thus, right pectoral implantation is feasible and offers an alternative approach in selected patients...
  38. ncbi Beta-blocker use and survival in patients with ventricular fibrillation or symptomatic ventricular tachycardia: the Antiarrhythmics Versus Implantable Defibrillators (AVID) trial
    D V Exner
    National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892, USA
    J Am Coll Cardiol 34:325-33. 1999
    ....
  39. ncbi Risk stratification and role of implantable defibrillators for prevention of sudden death in patients with hypertrophic cardiomyopathy
    Barry J Maron
    Hypertrophic Cardiomyopathy Center, Minneapolis Heart Institute Foundation, Minneapolis, MN 55407, USA
    Circ J 74:2271-82. 2010
    ..Indeed, prevention of SCD has now become a new paradigm in the management of HCM...
  40. pmc Design of the evolution of management strategies of heart failure patients with implantable defibrillators (EVOLVO) study to assess the ability of remote monitoring to treat and triage patients more effectively
    Maurizio Marzegalli
    Cardiology Department, S, Carlo Borromeo Hospital, Milan, Italy
    Trials 10:42. 2009
    Heart failure patients with implantable defibrillators (ICD) frequently visit the clinic for routine device monitoring...
  41. ncbi Prevention of inappropriate therapy in implantable defibrillators: A meta-analysis of clinical trials comparing single-chamber and dual-chamber arrhythmia discrimination algorithms
    Dominic A M J Theuns
    Department of Cardiology, Erasmus MC, Rotterdam, The Netherlands
    Int J Cardiol 125:352-7. 2008
    ..The aim of this meta-analysis was to establish whether dual-chamber arrhythmia discrimination algorithms reduce inappropriate device therapy...
  42. ncbi Antiarrhythmic drug use in the implantable defibrillator arm of the Antiarrhythmics Versus Implantable Defibrillators (AVID) Study
    J S Steinberg
    Division of Cardiology, St Luke s Roosevelt Hospital Center, New York, NY 10025, USA
    Am Heart J 142:520-9. 2001
    ..The objective of this clinical investigation was to study the need for, and effects of, concomitant AAD use with the ICD in a prospectively defined cohort...
  43. ncbi Electrical storm: a new challenge in the age of implantable defibrillators
    Konstantinos A Gatzoulis
    1st Department of Cardiology, Athens University Medical School, Greece
    Hellenic J Cardiol 49:86-91. 2008
  44. pmc "That's like an act of suicide" patients' attitudes toward deactivation of implantable defibrillators
    Nathan E Goldstein
    Department of Geriatrics, Mount Sinai School of Medicine, Box 1070, One Gustave Levy Place, New York, NY 10029, USA
    J Gen Intern Med 23:7-12. 2008
    ..To understand potential patient barriers to discussions about implantable cardioverter defibrillator (ICD) deactivation in patients with advanced illness...
  45. ncbi [Recommendations for protection against electromagnetic interference risk caused by pacemakers and implantable defibrillators in hospitals]
    Maurizio Santomauro
    Dipartimento di Cardiologia e Cardiochirurgia, Universita degli Studi Federico II, Via S Pansini, 5 80131 Napoli
    Ital Heart J Suppl 3:440-5. 2002
    ..The purpose of this work is to give useful indications for a correct in-hospital management of patients with PM or ICD, in order to avoid dangerous electromagnetic interference...
  46. ncbi Comparison of arrhythmia recurrence in patients presenting with ventricular fibrillation versus ventricular tachycardia in the Antiarrhythmics Versus Implantable Defibrillators (AVID) trial
    Merritt H Raitt
    Portland VA Medical Center, Oregon Health and Science University, Portland, Oregon, USA
    Am J Cardiol 91:812-6. 2003
    ..patients assigned to implantable cardioverter-defibrillator (ICD) therapy in the Antiarrhythmics Versus Implantable Defibrillators (AVID) trial to determine whether patients who receive an ICD after VT have arrhythmias during follow-up ..
  47. ncbi Natural history of Brugada syndrome: insights for risk stratification and management
    Silvia G Priori
    Molecular Cardiology Laboratories, IRCCS Fondazione Salvatore Maugeri and University of Pavia, Pavia, Italy
    Circulation 105:1342-7. 2002
    ..Furthermore, the value of programmed electrical stimulation (PES) for risk stratification is highly debated. The objective of this study was to search for novel parameters to identify patients at risk of sudden death...
  48. ncbi Inappropriate implantable cardioverter-defibrillator shocks in MADIT II: frequency, mechanisms, predictors, and survival impact
    James P Daubert
    Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
    J Am Coll Cardiol 51:1357-65. 2008
    ..This study sought to identify the incidence and outcome related to inappropriate implantable cardioverter-defibrillator (ICD) shocks, that is, those for nonventricular arrhythmias...
  49. ncbi Effects of cardiac resynchronization on disease progression in patients with left ventricular systolic dysfunction, an indication for an implantable cardioverter-defibrillator, and mildly symptomatic chronic heart failure
    William T Abraham
    Ohio State University Heart Center, Division of Cardiovascular Medicine, 473 W 12th Ave, Room 110P DHLRI, Columbus, OH 43210 1252
    Circulation 110:2864-8. 2004
    ..The effects of cardiac resynchronization therapy (CRT) in patients with mildly symptomatic heart failure have not been fully elucidated...
  50. ncbi Worldwide utilization of implantable cardioverter/defibrillators now and in the future
    K Seidl
    Herzzentrum Ludwigshafen, Department of Clinical Electrophysiology, Ludwigshafen, Germany seidlk klilu de
    Card Electrophysiol Rev 7:5-13. 2003
    ..This low acceptance may not be entirely related to budget constraint but also to the perceived efficacy of ICDs by physicians and health authorities...
  51. ncbi Cardiac resynchronization and death from progressive heart failure: a meta-analysis of randomized controlled trials
    David J Bradley
    Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
    JAMA 289:730-40. 2003
    ..Cardiac resynchronization, a pacemaker-based therapy for heart failure, enhances cardiac performance and quality of life, but its effect on mortality is uncertain...
  52. ncbi Prophylactic defibrillator implantation in patients with nonischemic dilated cardiomyopathy
    Alan Kadish
    Clinical Cardiology Trials Office, Division of Cardiology, Department of Medicine, Northwestern University Medical School, Chicago, USA
    N Engl J Med 350:2151-8. 2004
    ..However, the value of prophylactic implantation of an implantable cardioverter-defibrillator (ICD) to prevent sudden death in such patients is unknown...
  53. ncbi Pacemaker and defibrillator lead extraction
    Steven P Kutalek
    Cardiac Electrophysiology, Drexel University College of Medicine, Hahnemann University Hospital, Philadelphia, Pennsylvania 19102, USA
    Curr Opin Cardiol 19:19-22. 2004
    ..For these reasons, it is important to understand the expanding indications, procedural aspects, and limitations of arrhythmia device extraction...
  54. ncbi High defibrillation thresholds in transvenous biphasic implantable defibrillators: clinical predictors and prognostic implications
    Himanshu H Shukla
    Division of Cardiology, University of Missouri, Columbia, One Hospital Dr, MC314 Div of Cardiology, Columbia, MO 65212, USA
    Pacing Clin Electrophysiol 26:44-8. 2003
    ..Patients with a predicted low DFTs may be eligible for abbreviated ICD testing while high risk patients require formal testing...
  55. ncbi Differences in tachyarrhythmia detection and implantable cardioverter defibrillator therapy by primary or secondary prevention indication in cardiac resynchronization therapy patients
    Bruce L Wilkoff
    Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Cardiovasc Electrophysiol 15:1002-9. 2004
    ....
  56. ncbi Efficacy of quinidine in high-risk patients with Brugada syndrome
    Bernard Belhassen
    Department of Cardiology, Tel Aviv Sourasky Medical Center, and Tel Aviv University, Sackler School of Medicine, Weizman St 6, Tel Aviv 64239 Israel
    Circulation 110:1731-7. 2004
    ..Quinidine depresses I(to) current, which may play an important role in the arrhythmogenesis of this disease...
  57. ncbi Transjugular approach for lead extraction
    Hector Mazzetti
    Cardiology Division, Hospital Juan A Fernandez, Cerviño 3356, CP 1425 Buenos Aires, Argentina
    Europace 10:156-60. 2008
    ....
  58. ncbi Primary prevention of sudden cardiac death: the time of your life
    Eric N Prystowsky
    The Care Group, LLC, Indianapolis, Ind 46260 1919, USA
    Circulation 109:1073-5. 2004
  59. ncbi Microvolt T-wave alternans distinguishes between patients likely and patients not likely to benefit from implanted cardiac defibrillator therapy: a solution to the Multicenter Automatic Defibrillator Implantation Trial (MADIT) II conundrum
    Daniel M Bloomfield
    Data Coordinating Center, The MTWA in CHF Study, PH 9 103D, Department of Medicine, Columbia University, 630 W 168th St, New York, NY 10032, USA
    Circulation 110:1885-9. 2004
    ..We compared the ability of microvolt T-wave alternans and QRS duration to identify groups at high and low risk of dying among heart failure patients who met MADIT II criteria for ICD prophylaxis...
  60. ncbi Brugada syndrome: report of the second consensus conference: endorsed by the Heart Rhythm Society and the European Heart Rhythm Association
    Charles Antzelevitch
    Masonic Medical Research Laboratory, 2150 Bleecker St, Utica, NY 13501, USA
    Circulation 111:659-70. 2005
    ....
  61. ncbi Randomized comparison of antiarrhythmic drug therapy with implantable defibrillators in patients resuscitated from cardiac arrest : the Cardiac Arrest Study Hamburg (CASH)
    K H Kuck
    St Georg Hospital, Hamburg, Germany
    Circulation 102:748-54. 2000
    ..We conducted a prospective, multicenter, randomized comparison of implantable cardioverter-defibrillator (ICD) versus antiarrhythmic drug therapy in survivors of cardiac arrest secondary to documented ventricular arrhythmias...
  62. ncbi Predicting early mortality after implantable defibrillator implantation: a clinical risk score for optimal patient selection
    Ratika Parkash
    Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada
    Am Heart J 151:397-403. 2006
    ..The objective of this study was to develop a model to predict mortality within the first year after ICD implantation...
  63. ncbi Increasing hazard of Sprint Fidelis implantable cardioverter-defibrillator lead failure
    Robert G Hauser
    Minneapolis Heart Institute Foundation, Minneapolis, Minnesota, and Mayo Clinic, Rochester, Minnesota 55407, USA
    Heart Rhythm 6:605-10. 2009
    ..The rate of Sprint Fidelis lead failure may be increasing, and physicians are confronted with the decision to replace the lead prophylactically...
  64. ncbi Remote monitoring of CRT-ICD: the multicenter Italian CareLink evaluation--ease of use, acceptance, and organizational implications
    Maurizio Marzegalli
    S Carlo Borromeo Hospital, Milan, Italy
    Pacing Clin Electrophysiol 31:1259-64. 2008
    ..The Medtronic CareLink allows remote implantable device follow-up. In this first European experience with CareLink, we assessed the ease of use of the system, the acceptance, and satisfaction of patients and clinicians...
  65. ncbi Remote implantable cardioverter defibrillator monitoring in a Brugada syndrome population
    Frederic Sacher
    CHU de Bordeaux, Universite Bordeaux II, France
    Europace 11:489-94. 2009
    ..We investigated whether remote ICD monitoring could simplify follow-up and detect potential complications in these patients...
  66. ncbi Clinical profile of four families with arrhythmogenic right ventricular cardiomyopathy caused by dominant desmoplakin mutations
    Barbara Bauce
    Division of Cardiology, University of Padua Medical School, Padova, Italy
    Eur Heart J 26:1666-75. 2005
    ....
  67. ncbi Remote Active Monitoring in Patients with Heart Failure (RAPID-RF): design and rationale
    Leslie A Saxon
    University of Southern California, Los Angeles, California, USA
    J Card Fail 13:241-6. 2007
    ..However, the use and ultimate utility of these combined features for patient management are untested...
  68. ncbi Individualizing decisions for patients with prophylactic implantable cardiac defibrillators subject to device advisories: a commentary
    J Thomas Bigger
    Am J Cardiol 98:1291-3. 2006
  69. ncbi Risk factors related to infections of implanted pacemakers and cardioverter-defibrillators: results of a large prospective study
    Didier Klug
    Department of Cardiology A, Hopital Cardiologique de Lille, CHRU, 59037, Lille Cedex, France
    Circulation 116:1349-55. 2007
    ..The Prospective Evaluation of Pacemaker Lead Endocarditis study is a multicenter, prospective survey of the incidence and risk factors of infectious complications after implantation of pacemakers and cardioverter-defibrillators...
  70. ncbi Expanding indications for implantable cardiac defibrillators
    J Thomas Bigger
    N Engl J Med 346:931-3. 2002
  71. ncbi Microvolt T-wave alternans and the risk of death or sustained ventricular arrhythmias in patients with left ventricular dysfunction
    Daniel M Bloomfield
    Columbia University Medical Center, New York, New York 10032, USA
    J Am Coll Cardiol 47:456-63. 2006
    ..This study hypothesized that microvolt T-wave alternans (MTWA) improves selection of patients for implantable cardioverter-defibrillator (ICD) prophylaxis, especially by identifying patients who are not likely to benefit...
  72. ncbi Device-related infection among patients with pacemakers and implantable defibrillators: incidence, risk factors, and consequences
    Pablo B Nery
    University of Ottawa Heart Institute, Canada
    J Cardiovasc Electrophysiol 21:786-90. 2010
    ..Device-related infection is a major limitation of device therapy for cardiac arrhythmia...
  73. ncbi Patient Alert to detect ICD lead failure: efficacy, limitations, and implications for future algorithms
    Dirk Vollmann
    Abteilung Kardiologie und Pneumologie, Herzzentrum, Georg August Universitat Gottingen, Germany
    Europace 8:371-6. 2006
    ..We aimed to determine the utility of Patient Alert for ICD lead-failure detection in a prospective study...
  74. ncbi Cardiac resynchronization therapy for patients with left ventricular systolic dysfunction: a systematic review
    Finlay A McAlister
    The University of Alberta Evidence based Practice Center, Edmonton, Alberta, Canada
    JAMA 297:2502-14. 2007
    ..Atrial-synchronized biventricular pacemakers (cardiac resynchronization therapy [CRT]) received US Food and Drug Administration (FDA) approval for use in selected patients with LV systolic dysfunction in 2001...
  75. ncbi QRS duration does not predict occurrence of ventricular tachyarrhythmias in patients with implanted cardioverter-defibrillators
    Alfred E Buxton
    Cardiology Division, Department of Medicine, Brown Medical School, Providence, Rhode Island 02905, USA
    J Am Coll Cardiol 46:310-6. 2005
    ..The aim of this study was to determine whether QRS duration (QRSd) correlates with occurrence of ventricular arrhythmia in patients with coronary disease (CAD) receiving implantable cardioverter-defibrillators (ICDs)...
  76. ncbi Cardiac resynchronization therapy in patients with end-stage inotrope-dependent class IV heart failure
    Bengt Herweg
    Division of Cardiology, Tampa General Hospital, University of South Florida College of Medicine, Tampa, Florida, USA
    Am J Cardiol 100:90-3. 2007
    ..In conclusion, patients with end-stage inotrope-dependent NYHA class IV HF and LV dyssynchrony may respond favorably to CRT with long-term clinical benefit and improved LV function...
  77. ncbi Recalls and safety alerts involving pacemakers and implantable cardioverter-defibrillator generators
    W H Maisel
    Cardiovascular Division, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    JAMA 286:793-9. 2001
    ..Despite increasingly frequent device implantation, pacemaker and ICD recalls and safety alerts (advisories) remain poorly characterized...
  78. ncbi The cost of implantable defibrillators: perceptions and reality
    John Camm
    St George s University of London, Cranmer Terrace, London SW17 0RE, UK
    Eur Heart J 28:392-7. 2007
    ..Recent guidelines have recommended more wide-ranging indications for the use of implantable cardioverter defibrillator (ICD) therapy, yet even more restrained previous guidelines have not been implemented for a variety of reasons...
  79. ncbi Predictors of quality of life in patients with implantable cardioverter defibrillators
    Samuel F Sears
    Department of Clinical and Health Psychology, University of Florida, Box 100165, UF Health Science Center, Gainesville, FL 32610, USA
    Psychosomatics 46:451-7. 2005
    ..Further, psychological variables were as strong as, or stronger than, age, ejection fraction, and ICD shocks in predicting quality of life outcomes...
  80. ncbi Follow-up of patients with unexplained syncope and inducible ventricular tachyarrhythmias: analysis of the AVID registry and an AVID substudy. Antiarrhythmics Versus Implantable Defibrillators
    J S Steinberg
    St Luke s Roosevelt Hospital Center and Columbia University College of Physicians and Surgeons, New York, New York 10025, USA
    J Cardiovasc Electrophysiol 12:996-1001. 2001
    A prospective registry and substudy were conducted in the Antiarrhythmics Versus Implantable Defibrillators (AVID) Study to clarify the prognosis and recurrent event rate, risk factors, and impact of implantable cardioverter defibrillator ..
  81. pmc Comprehensive cardiac rehabilitation programme for implantable cardioverter-defibrillator patients: a randomised controlled trial
    A Fitchet
    Manchester Heart Centre, Manchester Royal Infirmary, Manchester, UK
    Heart 89:155-60. 2003
    ..To investigate the effects of a 12 week comprehensive cardiac rehabilitation (CCR) programme on patients who have undergone implantation of an implantable cardioverter-defibrillator (ICD)...
  82. ncbi Improved defibrillation efficacy with an ascending ramp waveform in humans
    Stephen R Shorofsky
    University of Maryland, Division of Cardiology, Baltimore, Maryland 21201, USA
    Heart Rhythm 2:388-94. 2005
    ..The purpose of this study was to compare an ascending ramp waveform (RAMP) with a standard, clinically available biphasic truncated exponential waveform (BTE) for defibrillation in humans...
  83. ncbi Stepped defibrillation waveform is substantially more efficient than the 50/50% tilt biphasic
    Karlheinz Seidl
    Herzzentrum, Ludwigshafen, Germany
    Heart Rhythm 3:1406-11. 2006
    ..The stepped waveform has three parts: the first portion is positive with two capacitors in parallel, the second is positive with the capacitors in series, and the last portion is negative, also with the capacitors in series...
  84. ncbi Effect of cardiac and noncardiac conditions on survival after defibrillator implantation
    Douglas S Lee
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    J Am Coll Cardiol 49:2408-15. 2007
    ..We sought to examine outcomes in recipients of implantable cardioverter-defibrillators (ICDs) and the effect of age, gender, and comorbidities on survival...
  85. ncbi Fatal inappropriate ICD shock
    Christian Veltmann
    Department of Medicine, University Hospital Mannheim, Mannheim, Germany
    J Cardiovasc Electrophysiol 18:326-8. 2007
    ....
  86. ncbi Four-year efficacy of cardiac resynchronization therapy on exercise tolerance and disease progression: the importance of performing atrioventricular junction ablation in patients with atrial fibrillation
    Maurizio Gasparini
    Department of Cardiology, IRCCS, Istituto Clinico Humanitas Rozzano Milano, Milan, Italy
    J Am Coll Cardiol 48:734-43. 2006
    ..The goal of this study was to investigate the effects of cardiac resynchronization therapy (CRT) in heart failure patients with permanent atrial fibrillation (AF) and the role of atrioventricular junction (AVJ) ablation...
  87. ncbi Pocket hematoma after pacemaker or implantable cardioverter defibrillator surgery: influence of patient morbidity, operation strategy, and perioperative antiplatelet/anticoagulation therapy
    Uwe K H Wiegand
    Universitaet zu Lübeck, Medizinische Klinik II, Ratzeburger Allee 160, 23538 Luebeck, Germany
    Chest 126:1177-86. 2004
    ..Thus, we investigated the influence of patient comorbidity, implantation strategy, operator experience, antiplatelet therapy, and anticoagulation therapy on hematoma rate...
  88. ncbi The role of remote monitoring in the reduction of inappropriate implantable cardioverter defibrillator therapies
    J C J Res
    Department of Electrophysiology, Erasmus Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands
    Clin Res Cardiol 95:III17-21. 2006
    ..One of the most inconvenient side-effects of the ICD therapy is inappropriate intervention of the device. Home Monitoring data can help the physician to identify and subsequently reduce the incidence of inappropriate ICD therapy...
  89. ncbi Early automatic remote detection of combined lead insulation defect and ICD damage
    Petr Neuzil
    Cardiology Department, Na Homolce Hospital, Roentgenova 2, Prague 5, Prague, Czech Republic
    Europace 10:556-7. 2008
    ..Immediate lead and device replacement was performed. This case illustrates the benefit of permanent automatic remote monitoring of implanted active devices...
  90. ncbi Cost-effectiveness of implantable cardioverter-defibrillators
    Gillian D Sanders
    Duke Clinical Research Institute, Duke University, Durham, NC 27715, USA
    N Engl J Med 353:1471-80. 2005
    ..We assessed the cost-effectiveness of the ICD in the populations represented in these primary-prevention trials...
  91. ncbi Clinical course and implantable cardioverter defibrillator therapy in postinfarction women with severe left ventricular dysfunction
    Wojciech Zareba
    Cardiology Unit, Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642 8653, USA
    J Cardiovasc Electrophysiol 16:1265-70. 2005
    ..The aim of this study was to evaluate the risk of cardiac events and effects of ICD therapy in women as compared to men enrolled in the Multicenter Automatic Defibrillator Implantation Trial II (MADIT II)...
  92. ncbi Determinants of mortality in patients undergoing cardiac resynchronization therapy: baseline clinical, echocardiographic, and angioscintigraphic evaluation prior to resynchronization
    Antonio De Sisti
    Cardiology Unit, Hopital Europeen Georges Pompidou, Paris, France
    Pacing Clin Electrophysiol 28:1260-70. 2005
    ..In dilated cardiomyopathy (DCM) patients (pts) with cardiac resynchronization therapy (CRT) for ventricular dyssynchrony, long-term predictors of mortality and morbidity remain poorly investigated...
  93. ncbi Measuring patient acceptance of implantable cardiac device therapy: initial psychometric investigation of the Florida Patient Acceptance Survey
    Jason L Burns
    Department of Clinical Health Psychology, University of Florida, Gainesville, Florida 32610, USA
    J Cardiovasc Electrophysiol 16:384-90. 2005
    ..This study sought to validate a new measure of patient acceptance of cardiac implantable devices called the Florida Patient Acceptance Survey (FPAS)...
  94. ncbi Cardiovascular device development: lessons learned from pacemaker and implantable cardioverter-defibrillator therapy
    William H Maisel
    Cardiovascular Division, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Am J Ther 12:183-5. 2005
    ....
  95. ncbi Implantable cardioverter-defibrillators: expanding indications and technologies
    Zachary Goldberger
    Department of Medicine, University of Washington Medical Center, Seattle, USA
    JAMA 295:809-18. 2006
    ..Since its introduction, there have been numerous advances in ICD technology, and indications for its use have expanded greatly in the past year...
  96. ncbi The National ICD Registry: now and into the future
    Stephen Hammill
    Mayo Clinic, Rochester, Minnesota 55905, USA
    Heart Rhythm 3:470-3. 2006
  97. ncbi Sophisticated remote implantable cardioverter-defibrillator follow-up: a status report
    Mark H Schoenfeld
    Hospital of Saint Raphael, Yale University School of Medicine, New Haven, CT 06511, USA
    Pacing Clin Electrophysiol 28:235-40. 2005
  98. ncbi What evidence do we have to replace in-hospital implantable cardioverter defibrillator follow-up?
    P Brugada
    O L V Hospital, Cardiovascular Center, Moorselbaan 164, 9300 Aalst, Belgium
    Clin Res Cardiol 95:III3-9. 2006
    ..Due to the increasing number of patients with an implantable cardioverter defibrillator (ICD), new options for ICD patient follow-up management are required...
  99. ncbi Follow-up of CRT-ICD: implications for the use of remote follow-up systems. Data from the InSync ICD Italian Registry
    Maurizio Lunati
    Niguarda Hospital, Milan, Italy
    Pacing Clin Electrophysiol 31:38-46. 2008
    ..Launch of remote follow-up systems in Europe is currently underway. However, there is insufficient understanding of postimplant practices with respect to device follow-up, reprogramming of device features, and postshock clinic visits...
  100. ncbi Large, single-center, single-operator experience with transvenous lead extraction: outcomes and changing indications
    Samuel O Jones
    Arrhythmia Service, Department of Cardiovascular Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, USA
    Heart Rhythm 5:520-5. 2008
    ..Lead extraction is increasingly necessary given the exponential growth in cardiac device implantation. Meanwhile, the tools, indications, and outcomes of this procedure continue to change...
  101. ncbi A brief cognitive behavioural preimplantation and rehabilitation programme for patients receiving an implantable cardioverter-defibrillator improves physical health and reduces psychological morbidity and unplanned readmissions
    R J Lewin
    Department of Health Sciences, BHF Care and Education Research Group, University of York, Heslington, York, UK
    Heart 95:63-9. 2009
    ..To assess the clinical and cost effectiveness of a brief home-based cognitive behavioural rehabilitation programme (the ICD Plan) for patients undergoing implantation of a cardiac defibrillator...

Research Grants64

  1. Applications of Magnetic Resonance for Management of Ventricular Tachycardia
    Saman Nazarian; Fiscal Year: 2013
    ..Even upon identification of high-risk patients, current treatments for VT are not ideal. Implantable defibrillators cause painful shocks and decrease quality of life, and catheter ablation is associated with failures ..
  2. Optical Mapping of the Onset of Ventricular Arrhythmias
    Jack M Rogers; Fiscal Year: 2013
    ..Many patients with nonischemic heart failure are now receiving implantable defibrillators for primary prevention of sudden death, highlighting the importance of improved understanding of ..
  3. Electrophysiological Effects of Neural Remodeling of the Ventricles
    Kalyanam Shivkumar; Fiscal Year: 2013
    ..Therefore, neuraxial modulation is an approach that has the potential to have a global impact given the prohibitive high cost and morbidity associated with implantable defibrillators which prevent their expanded use.
  4. Predicting anxiety symptoms in patients with implantable defibrillators
    Julia Betensky; Fiscal Year: 2010
    ..The novel findings that are anticipated may begin to lay the groundwork for developing tailored interventions to prevent the onset of post-implant anxiety. ..
  5. Medical Sensor Applications of Tunnel Magnetoresistance (TMR)
    Robert J Knuesel; Fiscal Year: 2012
    ..These products include pacemakers, implantable defibrillators, neurostimulators, and drug pumps...
  6. High-Voltage Compact Capacitor for Implantable Defibrillator
    BADAWI M DWEIK; Fiscal Year: 2010
    ..in intimate contact), miniaturized, and all-solid high-voltage capacitor for the next generation of implantable defibrillators. The all-solid high-voltage capacitor is attractive because it can store several times as much energy as ..
  7. ECG MEASUREMENTS OF VENTRICULAR ARRHYTHMIA MECHANISMS
    EDWARD BERBARI; Fiscal Year: 1999
    ..These life threatening ventricular tachyarrhythmias have been treated with anti-arrhythmic drugs and/or implantable defibrillators with variable success...
  8. PHYSIOLOGIC BENEFITS OF BIVENTRICULAR PACING IN CHF
    Mohamed Hamdan; Fiscal Year: 2002
    ..Similarly, a reduction in inducibility of ventricular arrhythmias, if present with long term pacing, may have an impact on the survival and on our management of patients with implantable defibrillators and frequent shocks.
  9. MINIATURIZED CAPACITOR FOR IMPLANTABLE DEFIBRILLATOR
    BADAWI DWEIK; Fiscal Year: 2001
    ..miniaturized, all solid hybrid capacitor type (Electrochemical-Electrolytic) for the next generation of implantable defibrillators. The capacitor consists of a modified porous tantalum oxide structure of a high-voltage electrolytic ..
  10. Center for Quantitative Electrocardiography and Cardiac Safety
    Jean Philippe Couderc; Fiscal Year: 2009
    ..the improvement of risk stratification techniques to optimize the use of prophylactic therapies such as implantable defibrillators and drug therapies...
  11. PHOTONIC TREATMENT OF ATRIAL ARRHYTHMIA
    EDWARD SINOFSKY; Fiscal Year: 1999
    ..several other therapies are in clinical evaluation including RF, cryoablation and microwave ablation and implantable defibrillators; however, all are considered sub-optimal...
  12. Adv Miniaturized Capacitor for Implantable Defibrillator
    BADAWI DWEIK; Fiscal Year: 2003
    ..characteristics of hybrid capacitor could be critical drivers for selection of this technology for implantable defibrillators. Incorporating the solid electrolyte would eliminate any possibility of electrolyte leakage, thus ..
  13. DEFIBRILLATOR WAVESHAPE OPTIMIZATION
    Janice Jones; Fiscal Year: 2002
    ..of defibrillation mechanisms and produce improved waveforms to allow development of new smaller, safer implantable defibrillators. New testing algorhythmis will also allow defibrillator testing without inducing very risky multiple ..
  14. THERMOPLASTIC POLYURETHANE WITH ENHANCED BIOSTABILITY
    ALAN ZAMORE; Fiscal Year: 2001
    ..pacemaker leads, Vascular grafts, Artifical hearts, Neurological leads, Arterio-venous dialysis shunts, Implantable defibrillators, Wound dressings, Cardiac catheter, Urethral catheters Mammary prostheses, IV bags and tubing, ..
  15. Electrophysiologic effects of late PCI (OAT-EP)
    Stephen Shorofsky; Fiscal Year: 2005
    ....
  16. Prognostic significance of T wave variability
    Eric Rashba; Fiscal Year: 2006
    ..2) Patients with increased T wave variability derive a greater mortality benefit from prophylactic ICD implantation. ..
  17. THROMBOGENIC FACTORS AND RECURRENT CORONARY EVENTS
    Arthur Moss; Fiscal Year: 2003
    ..abstract_text> ..
  18. THERAPUTIC TRIAL IN PATIENTS WITH LQTS 3 GENE MUTATION
    Arthur Moss; Fiscal Year: 2002
    ..The significance of this work relates to the future use of molecular therapeutics to treat ion-channel disorders associated with congenital and acquired cardiac repolarization disorders. ..
  19. LONG QT SYNDROME--GENETIC STUDIES
    Arthur Moss; Fiscal Year: 2002
    ....
  20. Arrhythmia Assessment Core Lab for IMMEDIATE Trial
    Eric Rashba; Fiscal Year: 2006
    ..End of abstract.) [unreadable] [unreadable]..
  21. NURSING INTERVENTIONS FOLLOWING SUDDEN CARDIAC ARREST
    CYNTHIA DOUGHERTY; Fiscal Year: 2001
    ..The findings are expected to be generalizable to other populations of high risk patients who leave the hospital after a very short stay, and to whom close follow-up cre by advanced practice nurses would be advantageous. ..
  22. Emotional Reactivity: A Trigger of Atrial Fibrillation
    Rachel Lampert; Fiscal Year: 2008
    ..Determining triggers of AF, and identifying individuals at increased risk of recurrence, may lead to future therapeutic interventions aimed at decreasing the effects of triggers on the individual patient. ..
  23. Sex Differences in Early Myocardial Repolarization
    Alan Kadish; Fiscal Year: 2008
    ..It is hoped that the results of this study will improve the understanding of myocardial physiology and improve risk stratification and therapy for arrhythmias by uncovering important sex related differences. ..
  24. ECONOMIC OUTCOMES OF TREATMENT STRATEGIES IN BAR1-2
    Mark Hlatky; Fiscal Year: 2006
    ..The investigators further expect that this collaborative effort will translate into a new practical clinical paradigm that will be used for treatment of Type II diabetic patients. ..
  25. Gene Targets of NKX 2.5 in the Conduction System
    Melvin Scheinman; Fiscal Year: 2004
    ..MinK and HCN-1) in the pathogenesis of arrhythmias in the ventricular restricted knockout mouse model. This will be done by using in-situ hybridization and immunohistochemistry to follow the pattern of expression of these ion channels. ..
  26. NEURAL MECHANISMS OF VENTRICULAR ELECTRICAL REMODELING
    Philip Adamson; Fiscal Year: 2003
    ..These clinically applicable interventions may modify the natural history of diseases, such as heart failure, characterized by ventricular electrical remodeling leading to a high risk for lethal arrhythmias. ..
  27. COMPUTER BASED GUIDELINES TO PREVENT SUDDEN CARDIAC DEAT
    GILLIAN SANDERS; Fiscal Year: 2002
    ..abstract_text> ..
  28. MODIFIABLE RISK FACTORS FOR SUDDEN DEATH IN MEN/WOMEN
    Christine Albert; Fiscal Year: 2002
    ..At the end of the proposed research program, Dr. Albert will have attained advanced epidemiologic skills which can then be applied to independent research in her chosen subspecialty of electrophysiology. ..
  29. Genetic Determinants of Sudden Cardiac Death
    Christine Albert; Fiscal Year: 2006
    ..The findings generated will have substantial implications for our understanding of the SCD syndrome and risk stratification in the general population. ..
  30. TRIGGERS OF VENTRICULAR ARRHYTHMIAS (TOVA) STUDY
    Christine Albert; Fiscal Year: 2002
    ..Characterization of triggering of ICD discharge will provide insights valuable for prevention of sudden death due to primary arrhythmias in the general population. ..
  31. Modifiable Determinants of Ventricular Arrythmias
    Christine Albert; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  32. Visualizing the Substrate for Sudden Cardiac Death
    Vivek Reddy; Fiscal Year: 2006
    ..abstract_text> ..
  33. Cost Effectiveness of Catheter Ablation for Atrial Fibrillation (AF)
    Matthew Reynolds; Fiscal Year: 2008
    ..Once all of this data is collected, the necessary inputs will combined in a Markov model comparing AF ablation with antiarrhythmic drug therapy, and atrio-ventricular junctional ablation with pacemaker implantation. ..
  34. VENTRICULAR FIBRILLATION AND ITS ALTERATION BY PACING
    Raymond E Ideker; Fiscal Year: 2010
    ..We will test the hypotheses that pacing from the dominant domain (1) captures the maximum amount of tissue during VF and (2) halts the most organized types of VF. ..
  35. COMPUTER ASSISTED MAPPING OF VENTRICULAR FIBRILLATION
    Raymond Ideker; Fiscal Year: 2009
    ..This understanding will give us new information needed to develop therapies to counteract these mechanisms of VF maintenance to prevent sudden cardiac arrest, one of the leading health problems in the world today. ..
  36. Tau Nitration in Alzheimer's Pathogenesis
    Matthew Reynolds; Fiscal Year: 2007
    ..In this proposal, we will characterize the specific sites of T nitration in vitro and in situ, and determine the effects of nitration on T folding and function. ..
  37. ACTION-A CHF TRIAL INVESTIGATING OUTCOMES OF EXERCISE
    William Abraham; Fiscal Year: 2005
    ..The trial will take place over 5 years with an initial 6 months for planning, training, and implementation; 3 years of enrollment; 1 year of follow-up; and 6 months for close out, analysis, and presentation. ..
  38. CARDIAC MAPPING OF VENTRICULAR DEFIBRILLATION
    Raymond Ideker; Fiscal Year: 2006
    ..It is hoped that the basic knowledge gained about defibrillation mechanisms through these studies will lead to the improvement of defibrillation in patients. ..
  39. Cardiac Parasympathetic Effect in Exercise and Recovery
    Jeffrey Goldberger; Fiscal Year: 2006
    ..abstract_text> ..
  40. Substrate Mapping & Ablation of Ventricular Tachycardia
    Vivek Reddy; Fiscal Year: 2006
    ..risk for sudden cardiac death, malignant ventricular tachycardia (VT) is treated with a combination of implantable defibrillators and antiarrhythmic drugs...
  41. ESCAPE Mechanistic Substudies
    Robert Califf; Fiscal Year: 2003
    ..Catecholamines are also being collected at baseline and 3 months. In addition, the ESCAPE investigators are all ready capturing detailed demographic, clinical, and physiological information as part of the protocol for the primary study. ..
  42. Economic and Policy Analyses in Geriatric Disease
    EKATERINA NOYES; Fiscal Year: 2006
    ..The model and analytical approaches acquired by the candidate during her training will be used later to develop a decision analytical model describing geriatric depression. ..
  43. Pathophysiology/Clinical Outcomes/Patients/Endocarditis
    Christopher Cabell; Fiscal Year: 2005
    ..The findings of this study have implications not only for clinical care but will also provide a foundation of knowledge and network of investigators from which subsequent randomized trials can be conducted. ..
  44. AGONIST-AND OXIDANT-STIMULATED SIGNALING MECHANISMS
    ROY ZIEGELSTEIN; Fiscal Year: 2004
    ..The proposed studies could lead to novel methods of regulating proinflammatory gene expression by specifically targeting upstream signaling mechanisms in the endothelium. ..
  45. Non-Invasive Localization of Vulnerable Plaques
    Cynthia McCollough; Fiscal Year: 2009
    ....
  46. Molecular Pathology of Cardic Arrhythmias
    Dan Roden; Fiscal Year: 2003
    ..abstract_text> ..
  47. A Family Partnership Intervention for Heart Failure
    Sandra Dunbar; Fiscal Year: 2009
    ..abstract_text> ..
  48. Cardiac care in specialty and general hospitals
    Peter M Cram; Fiscal Year: 2010
    ..Together these analyses will provide much needed information on the relative quality of care provided by specialty cardiac hospitals to policy makers, payors, providers and patients. ..
  49. Old Age, Life Extension, and Geriatrics
    SHARON KAUFMAN; Fiscal Year: 2005
    ..abstract_text> ..
  50. Surveying & Assessing Firefighter Fitness & Electrocardiography: The SAFFE Study
    Mary Carey; Fiscal Year: 2009
    ....
  51. Safer Antithrombotic Therapy for Elderly ACS Patients
    Eric Peterson; Fiscal Year: 2006
    ..Finally, we will use established relations with professional societies and the VHA to widely disseminate our study's major findings. ..
  52. Multidisciplinary Study of Right Ventricular Dysplasia
    Wojciech Zareba; Fiscal Year: 2005
    ..This integrated research grant proposal offers a substantial prospect of expanding the fund of clinical knowledge regarding ARVD and of localizing the gene(s) responsible for this disorder. ..
  53. Mitochondria and Cardiac Cell Death
    James Weiss; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  54. Mitochondria and surgical myopreservation in aging
    Arshad Jahangir; Fiscal Year: 2006
    ..This is especially relevant for cardiac surgery in the elderly, with the ultimate goal of limiting post-bypass pump failure. ..
  55. CLINICAL RESEARCH TRAINING PROGRAM
    Jack Zwanziger; Fiscal Year: 2008
    ..abstract_text> ..
  56. Heart Failure: Epidemiology & Outcomes in the Elderly
    Lesley Curtis; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  57. Automated Storage and Retrieval of Biological Systems
    Dan Roden; Fiscal Year: 2008
    ..Accordingly, this proposal requests a high end instrument to accomplish these goals, and to thereby enable a new era of Personalized Medicine. [unreadable] [unreadable] [unreadable] [unreadable]..
  58. Decision Making in End-Stage Heart Failure
    Paul Hauptman; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  59. Improving Self Management and Outcomes in Heart Failure Patients with Diabetes
    Sandra B Dunbar; Fiscal Year: 2010
    ..The outcomes to be measured are knowledge, self efficacy, and self care behaviors, biomarkers of heart failure and diabetes, and health resource use. ..
  60. PSYCHOEDUCATIONAL INTERVENTION FOR ICD PATIENTS
    Sandra Dunbar; Fiscal Year: 2003
    ..abstract_text> ..
  61. Utility of a New Database to Study Drug Safety during Pregnancy
    SOKO SETOGUCHI IWATA; Fiscal Year: 2008
    ..This database based on large population-based follow-up data with linkable clinical birth data has the potential to enhance the safety of prescription drug use in pregnant women and their children. [unreadable] [unreadable] [unreadable]..