experimental implants

Summary

Summary: Artificial substitutes for body parts and materials inserted into organisms during experimental studies.

Top Publications

  1. ncbi Performance of hydroxyapatite bone repair scaffolds created via three-dimensional fabrication techniques
    Tithi Dutta Roy
    Departtment of Orthopaedics, UMDNJ New Jersey Medical School, 185 South Orange Avenue, MSB G 574, Newark, New Jersey 07103, USA
    J Biomed Mater Res A 67:1228-37. 2003
  2. ncbi Locally delivered TGF-beta1 and IGF-1 enhance the fixation of titanium implants: a study in dogs
    Anders Lamberg
    Department of Orthopaedic Surgery, Aarhus University Hospital, Denmark
    Acta Orthop 77:799-805. 2006
  3. ncbi Effect of recombinant human bone morphogenetic protein-2 on bone regeneration and osseointegration of dental implants
    N Sykaras
    Private Practice, Athens, Greece
    Clin Oral Implants Res 12:339-49. 2001
  4. ncbi The early remodeling phases around titanium implants: a histomorphometric assessment of bone quality in a 3- and 6-month study in sheep
    D Chappard
    Laboratoire d Histologie Embryologie, CHU and Faculté de Médecine, Angers, France
    Int J Oral Maxillofac Implants 14:189-96. 1999
  5. ncbi In vivo effects of RGD-coated titanium implants inserted in two bone-gap models
    Brian Elmengaard
    Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Aarhus University Hospital, AKH, Norrebrogade 44, bygn 1a, DK 8000 Aarhus C, Denmark
    J Biomed Mater Res A 75:249-55. 2005
  6. ncbi RhBMP-2/alphaBSM induces significant vertical alveolar ridge augmentation and dental implant osseointegration
    Ulf M E Wikesjö
    Laboratory for Applied Periodontal and Craniofacial Regeneration, Department of Periodontology, Temple University School of Dentistry, Philadelphia, PA 19140, USA
    Clin Implant Dent Relat Res 4:174-82. 2002
  7. pmc Increased adenine nucleotide translocator 1 in reactive astrocytes facilitates glutamate transport
    Charles R Buck
    Oridis Biomed, Elisabethstrasse 84, A 8010, Graz, Austria
    Exp Neurol 181:149-58. 2003
  8. ncbi Biomechanical measurements of calcium-incorporated oxidized implants in rabbit bone: effect of calcium surface chemistry of a novel implant
    Young Taeg Sul
    Department of Biomaterials Handicap Research, University of Gothenburg, Gothenburg, Sweden
    Clin Implant Dent Relat Res 6:101-10. 2004
  9. ncbi The effects of ion beam-assisted deposition of hydroxyapatite on the grit-blasted surface of endosseous implants in rabbit tibiae
    Young Seok Park
    Department of Oral Anatomy, College of Dentistry, Seoul National University, Seoul, Korea
    Int J Oral Maxillofac Implants 20:31-8. 2005
  10. ncbi Mechanical and histologic examination of titanium alloy material treated by sandblasting and anodic oxidization
    Akiyoshi Yamagami
    Kyoto Institute of Implantology, Kyoto, Japan
    Int J Oral Maxillofac Implants 20:48-53. 2005

Research Grants

  1. BIOMEDICAL RESEARCH SUPPORT
    Donald Bers; Fiscal Year: 1991
  2. Periodontal Disease and Rheumatoid Arthritis
    Michael McCracken; Fiscal Year: 2005
  3. 8th Conference - Chemistry & Biology Mineralized Tissue
    WILLIAM LANDIS; Fiscal Year: 2004
  4. MINERAL-MATRIX RELATIONS IN CALCIFYING TISSUES
    WILLIAM LANDIS; Fiscal Year: 2006
  5. Mineral and Mechanical Properties of Bone
    Sarandeep Huja; Fiscal Year: 2005
  6. Effect of Diabetes on Bone Integration of Implants
    Michael McCracken; Fiscal Year: 2002
  7. TREATMENT OF AORTIC ANEURYSMS
    Naren Vyavahare; Fiscal Year: 2007
  8. Detection of Live Fibers in Injured Spinal Cord
    Mehmet Bilgen; Fiscal Year: 2007
  9. Skin Adaptation to Mechanical Stress
    Joan Sanders; Fiscal Year: 2006
  10. INTERFACE MECHANICS, MATERIALS AND TISSUE RESPONSE
    Joan Sanders; Fiscal Year: 2007

Detail Information

Publications221 found, 100 shown here

  1. ncbi Performance of hydroxyapatite bone repair scaffolds created via three-dimensional fabrication techniques
    Tithi Dutta Roy
    Departtment of Orthopaedics, UMDNJ New Jersey Medical School, 185 South Orange Avenue, MSB G 574, Newark, New Jersey 07103, USA
    J Biomed Mater Res A 67:1228-37. 2003
    ..Therefore, the current study indicates that scaffold geometry, as determined by the fabrication process, can enhance the ability of a ceramic material to accelerate healing of calvarial defects...
  2. ncbi Locally delivered TGF-beta1 and IGF-1 enhance the fixation of titanium implants: a study in dogs
    Anders Lamberg
    Department of Orthopaedic Surgery, Aarhus University Hospital, Denmark
    Acta Orthop 77:799-805. 2006
    ..We examined the effect of locally delivered transforming growth factor-beta1 and insulin-like growth factor-1 in a biodegradable poly (D, L-lactide) coating...
  3. ncbi Effect of recombinant human bone morphogenetic protein-2 on bone regeneration and osseointegration of dental implants
    N Sykaras
    Private Practice, Athens, Greece
    Clin Oral Implants Res 12:339-49. 2001
    ..b>Experimental implants had their hollow chamber filled with 20 microg of rhBMP-2 delivered with a bovine collagen carrier, ..
  4. ncbi The early remodeling phases around titanium implants: a histomorphometric assessment of bone quality in a 3- and 6-month study in sheep
    D Chappard
    Laboratoire d Histologie Embryologie, CHU and Faculté de Médecine, Angers, France
    Int J Oral Maxillofac Implants 14:189-96. 1999
    ..The remodeling process appeared to improve bone quality and increase the bone-titanium interface around implants, while the net bone quantity necessary to immobilize implants was achieved rapidly and remained unchanged...
  5. ncbi In vivo effects of RGD-coated titanium implants inserted in two bone-gap models
    Brian Elmengaard
    Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Aarhus University Hospital, AKH, Norrebrogade 44, bygn 1a, DK 8000 Aarhus C, Denmark
    J Biomed Mater Res A 75:249-55. 2005
    ..RGD peptide coatings can potentially be used to enhance tissue integration in these challenging environments...
  6. ncbi RhBMP-2/alphaBSM induces significant vertical alveolar ridge augmentation and dental implant osseointegration
    Ulf M E Wikesjö
    Laboratory for Applied Periodontal and Craniofacial Regeneration, Department of Periodontology, Temple University School of Dentistry, Philadelphia, PA 19140, USA
    Clin Implant Dent Relat Res 4:174-82. 2002
    ..Several candidate carriers, however, lack structural integrity to offset compressive forces that may compromise rhBMP-2 bone induction, in particular, for challenging onlay indications such as alveolar ridge augmentation...
  7. pmc Increased adenine nucleotide translocator 1 in reactive astrocytes facilitates glutamate transport
    Charles R Buck
    Oridis Biomed, Elisabethstrasse 84, A 8010, Graz, Austria
    Exp Neurol 181:149-58. 2003
    ..Thus, the astrocytic response to CNS injury includes an apparent increase in energy mobilization capacity by Ant1 that contributes to neuroprotective, energy-dependent glutamate uptake...
  8. ncbi Biomechanical measurements of calcium-incorporated oxidized implants in rabbit bone: effect of calcium surface chemistry of a novel implant
    Young Taeg Sul
    Department of Biomaterials Handicap Research, University of Gothenburg, Gothenburg, Sweden
    Clin Implant Dent Relat Res 6:101-10. 2004
    ..However, clinical demands for stronger and faster bone bonding to the implant (eg, in immediately loaded and compromised bone cases) have motivated the development of novel surfaces capable of chemical bonding...
  9. ncbi The effects of ion beam-assisted deposition of hydroxyapatite on the grit-blasted surface of endosseous implants in rabbit tibiae
    Young Seok Park
    Department of Oral Anatomy, College of Dentistry, Seoul National University, Seoul, Korea
    Int J Oral Maxillofac Implants 20:31-8. 2005
    ..This study was undertaken to evaluate ion beam-assisted deposition (IBAD) of hydroxyapatite (HA) on the grit-blasted surface of endosseous dental implants 6 weeks postplacement...
  10. ncbi Mechanical and histologic examination of titanium alloy material treated by sandblasting and anodic oxidization
    Akiyoshi Yamagami
    Kyoto Institute of Implantology, Kyoto, Japan
    Int J Oral Maxillofac Implants 20:48-53. 2005
    ..Further detailed examination is required to demonstrate that the surface treatment used for group C (a micro rough surface on a macro rough surface structure) can enhance active bone formation and stable fixation in bone tissue...
  11. ncbi Bone tissue induction, using a COLLOSS-filled titanium fibre mesh-scaffolding material
    X Frank Walboomers
    Department of Periodontology and Biomaterials, University Medical Center, P O Box 9101, THK 117 PB, 6500 HB Nijmegen, The Netherlands
    Biomaterials 26:4779-85. 2005
    ..In conclusion, we can say that COLLOSS material loaded in a titanium fibre mesh tube, showed bone-inducing properties. The final efficacy of these osteo-inductive properties has to be confirmed in future large animal studies...
  12. ncbi The bone response of oxidized bioactive and non-bioactive titanium implants
    Young Taeg Sul
    Department of Biomaterials Handicap Research, Institute for Surgical Sciences, Goteborg University, Box 412, S 405 30 Goteborg, Sweden
    Biomaterials 26:6720-30. 2005
    ..However, the present study does not rule out potential synergy effects of the oxide thickness, micro-porous structure, crystal structure and surface roughness on improvements of bone responses to oxidized bioactive implants...
  13. ncbi Prefabrication of vascularized bone graft using a combination of fibroblast growth factor-2 and vascular bundle implantation into a novel interconnected porous calcium hydroxyapatite ceramic
    Tomoyuki Nakasa
    Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    J Biomed Mater Res A 75:350-5. 2005
    ..This study showed the potential of creating a vascularized bone graft of a predetermined size and shape using a combination of FGF-2 and vascular bundle implantation in the IP-CHA...
  14. ncbi Effect of surface chemistry on the rate of osseointegration of sintered porous-surfaced Ti-6Al-4V implants
    Alex Tache
    Institute of Biomaterials and Biomedical Engineering, University of Toronto, Ontario, Canada
    Int J Oral Maxillofac Implants 19:19-29. 2004
    ..The effect of adding a thin sol-gel-formed calcium phosphate (CaP) coating to sintered porous-surfaced titanium alloy (Ti-6Al-4V) implants on rates of initial bone ingrowth was investigated...
  15. ncbi Bone formation at titanium porous oxide (TiUnite) oral implants in type IV bone
    Yi Hao Huang
    Laboratory for Applied Periodontal and Craniofacial Regeneration, Temple University School of Dentistry, 3223 North Broad Street, Philadelphia, PA 19140, USA
    Clin Oral Implants Res 16:105-11. 2005
    ..The objective of this study was to evaluate the local bone formation and osseointegration at TPO-modified implants in type IV bone...
  16. ncbi Surface characteristics of implants influence their bone integration after simultaneous placement of implant and GBR membrane
    Luiz A Lima
    Division of Periodontics, Dental Branch, University of Sao Paulo, Sao Paulo, Brazil
    Clin Oral Implants Res 14:669-79. 2003
    ..TPS surfaces positively influenced the fraction of osseointegration in comparison to MS surfaces for both regenerated and pristine bone. Furthermore, early membrane removal negatively affected the fraction of bone defect fill...
  17. ncbi Short-term immunosuppressive therapy does not affect the density of the pre-existing bone around titanium implants placed in rabbits
    Poliana Mendes Duarte
    Department of Prosthodontics and Periodontics, School of Dentistry of Piracicaba, State University of Campinas
    Pesqui Odontol Bras 17:362-6. 2003
    ..Thus, it appears that a short-term immunosuppressive therapy may not present a negative influence on the density of the pre-existing bone around titanium implants placed in rabbits...
  18. ncbi Calcium phosphate sol-gel-derived thin films on porous-surfaced implants for enhanced osteoconductivity. Part II: Short-term in vivo studies
    Lu Gan
    University of Toronto, Toronto, Canada
    Biomaterials 25:5313-21. 2004
    ....
  19. ncbi Short-term bone response to titanium implants coated with thin radiofrequent magnetron-sputtered hydroxyapatite in rabbits
    Shams Mohammadi
    Department of Biomaterials, Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden
    Clin Implant Dent Relat Res 5:241-53. 2003
    ..It has been suggested that calcium phosphate (CaP) coatings initiate faster bone growth around implants. A major concern about the viable use of these coatings has been their biologic performance related to the coating characteristics...
  20. ncbi Biological performance of uncoated and octacalcium phosphate-coated Ti6Al4V
    Pamela Habibovic
    Institute of Biomedical Technology, Department Bilthoven, Twente University, Professor Bronkhorstlaan 10 D, Bilthoven 3720 MB, Netherlands
    Biomaterials 26:23-36. 2005
    ..This study showed that CaPs in the form of coating on metal implants or in the form of bulk ceramic have a significantly positive effect on the bone healing process...
  21. ncbi Influence of implant taper on the primary and secondary stability of osseointegrated titanium implants
    Dominic O'Sullivan
    Bristol Dental School, Bristol, UK
    Clin Oral Implants Res 15:474-80. 2004
    ....
  22. ncbi Long-term bone response to titanium implants coated with thin radiofrequent magnetron-sputtered hydroxyapatite in rabbits
    Shams Mohammadi
    Department of Biomaterials, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Int J Oral Maxillofac Implants 19:498-509. 2004
    ..The present study was designed to investigate the long-term bone response around machined screw-type uncoated and calcium phosphate (CaP) -coated commercially pure titanium implants...
  23. ncbi In vivo absorption of porous apatite- and wollastonite-containing glass-ceramic
    Kunitaka Ohsawa
    Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    J Mater Sci Mater Med 15:859-64. 2004
    ..AW was absorbed continuously, and at six and 12 months the residual material corresponded to about 64 and 30% of the starting material, respectively. Porous AW may therefore be useful as an absorbable bone substitute...
  24. ncbi Comparative study of osteoconduction on micromachined and alkali-treated titanium alloy surfaces in vitro and in vivo
    Xiong Lu
    Department of Mechanical Engineering, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
    Biomaterials 26:1793-801. 2005
    ..In vivo experiments confirm the beneficial effect of alkaline treatment on osteoconduction. The results of in vivo experiments also indicate a synergistic effect of the alkaline treatment and the topographic pattern on osteoconduction...
  25. ncbi The bone-metal interface of defect and press-fit ingrowth of microwave plasma-chemical vapor deposition implants in the rabbit model
    Stephan Rupprecht
    Department of Oral and Cranio Maxillofacial Surgery, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Clin Oral Implants Res 16:98-104. 2005
    ..Microwave plasma chemical vapor-coated implant probes were tested in control and uncoated materials...
  26. ncbi In vivo characterization of titanium implants coated with synthetic hydroxyapatite by electrophoresis
    Cristina de Almeida Costa
    Department of Metallurgical and Materials Engineering, COPPE, UFRJ, Rio de Janeiro, RJ, Brazil
    Braz Dent J 16:75-81. 2005
    ....
  27. ncbi Ability of zirconia double coated with titanium and hydroxyapatite to bond to bone under load-bearing conditions
    Takashi Suzuki
    Department of Orthopaedic Surgery, Kyoto University Graduate School of Medicine, Shogoin Kawaharacho 54, Sakyo ku, Kyoto 606 8507, Japan
    Biomaterials 27:996-1002. 2006
    ..HTOZ has the ability to bond to bone equivalent to HTOC and TOC. HTOZ is an excellent material for components of cementless joint prostheses...
  28. ncbi Bone tissue responses to surface-modified zirconia implants: A histomorphometric and removal torque study in the rabbit
    Lars Sennerby
    Department of Biomaterials, Institute for Surgical Sciences, Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    Clin Implant Dent Relat Res 7:S13-20. 2005
    ..Little is known about how surface modification influences the stability and bone tissue response to zirconia implants...
  29. ncbi Histological and immunohistochemical analysis of initial and early osseous integration at chemically modified and conventional SLA titanium implants: preliminary results of a pilot study in dogs
    Frank Schwarz
    Department of Oral Surgery, Heinrich Heine University, Dusseldorf, Germany
    Clin Oral Implants Res 18:481-8. 2007
    ..The aim of the present pilot study was to investigate initial and early tissue reactions to modified (mod) and conventional sand-blasted, large grit and acid-etched (SLA) titanium implants...
  30. ncbi Histodynamics of bone tissue formation around immediately loaded cylindrical implants in the rabbit
    Katleen Vandamme
    Department of Prosthetic Dentistry BIOMAT Research Group, School of Dentistry, Oral Pathology and Maxillofacial Surgery, Faculty of Medicine, K U Leuven, Leuven, Belgium
    Clin Oral Implants Res 18:471-80. 2007
    ..The present study evaluated the influence of well-controlled mechanical stimuli on the tissue response around immediately loaded cylindrical turned titanium implants at two different observation periods...
  31. ncbi [Investigation of the tissue growth processes in porous implant]
    O V Galibin
    Tsitologiia 49:280-3. 2007
    ..Electronic scanning and morphological analysis demonstrated the certain integration of the pylon with the surrounding tissues. The latter opens a possibility for development of direct skeletal attachment of limb prostheses...
  32. ncbi Effect of a multiphasic anodic spark deposition coating on the improvement of implant osseointegration in the osteopenic trabecular bone of sheep
    Gianluca Giavaresi
    Laboratory of Experimental Surgery, Rizzoli Orthopaedic Institute, Bologna, Italy
    Int J Oral Maxillofac Implants 23:659-68. 2008
    ....
  33. ncbi Early bone tissue responses to turned and oxidized implants in the rabbit tibia
    Patricia Miranda Burgos
    Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    Clin Implant Dent Relat Res 10:181-90. 2008
    ..The mechanisms leading to a stronger bone response to oxidized titanium are not well understood...
  34. ncbi Evaluations of bone tissue integration to pure and alloyed titanium implants
    Victoria Franke Stenport
    Department of Prosthetic Dentistry Dental Materials Science, Institute of Odontology, Institute of Surgical Sciences, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Clin Implant Dent Relat Res 10:191-9. 2008
    ....
  35. ncbi Effect of hydroxyapatite and titania nanostructures on early in vivo bone response
    Luiz Meirelles
    Department of Prosthetic Dentistry, Institute of Odontology, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Clin Implant Dent Relat Res 10:245-54. 2008
    ..Hydroxyapatite (HA) or titania nanostructures were applied on smooth titanium implant cylinders. The aim was to investigate whether nano-HA may result in enhanced osseointegration compared to nano-titania structures...
  36. ncbi Comparative in vivo study of six hydroxyapatite-based bone graft substitutes
    Pamela Habibovic
    University of Twente, Department of Tissue Regeneration, Enschede, The Netherlands
    J Orthop Res 26:1363-70. 2008
    ....
  37. ncbi Photo-induced hydrophilicity enhances initial cell behavior and early bone apposition
    Takashi Sawase
    Division of Applied Prosthodontics, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Clin Oral Implants Res 19:491-6. 2008
    ..In the present study, the effect of photo-induced hydrophilicity on initial cell behavior and bone formation was evaluated...
  38. ncbi Treatment of a commercial, machined surface titanium implant with H2SO4/H2O2 enhances contact osteogenesis
    Marconi Gonzaga Tavares
    Department of Oral and Maxillofacial Surgery and Periodontology, Faculty of Dentistry of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    Clin Oral Implants Res 18:452-8. 2007
    ..The aim of this study was to evaluate whether this chemical treatment can also influence in vivo bone formation...
  39. ncbi Early trabecular bone healing around titanium implants: a histologic study in rabbits
    Elke Slaets
    Department of Prosthetic Dentistry, BIOMAT Research Group, Catholic University Leuven, Leuven, Belgium
    J Periodontol 78:510-7. 2007
    ..A detailed insight into the early healing response of trabecular bone to unloaded titanium implants is lacking...
  40. ncbi Stimulation of directed bone growth at oxidized titanium implants by macroscopic grooves: an in vivo study
    Jan Hall
    Nobel Biocare AB, Goteborg, Sweden
    Clin Implant Dent Relat Res 7:S76-82. 2005
    ..However, less is known about the influence of implant structures in the range of 50 to 200 microm...
  41. ncbi Titanium implant osseointegration with calcium pyrophosphate in rabbits
    Samuel Koo
    Center for Implantology, School of Dental Medicine, Boston University, 100 East Newton St, Suite G308, Boston, Massachusetts 02118, USA
    J Biomed Mater Res B Appl Biomater 76:373-80. 2006
    ..The morphometric analysis showed implants placed with calcium pyrophosphate resulted in smaller polyfluorochrome labeling area (p < 0.05)...
  42. pmc Bone apposition to titanium implants biocoated with recombinant human bone morphogenetic protein-2 (rhBMP-2). A pilot study in dogs
    Jurgen Becker
    Department of Oral Surgery, Westdeutsche Kieferklinik, Heinrich Heine University, 40225, Dusseldorf, Germany
    Clin Oral Investig 10:217-24. 2006
    ....
  43. ncbi Enhancement of osseointegration by generating a dynamic implant surface
    Eduardo A Anitua
    J Oral Implantol 32:72-6. 2006
    ..28% +/- 4.7% vs 21.89% +/- 7.36%; P < .01). Finally, studies in patients showed that 99.6% of the implants treated with PRGF were well osseointegrated. Clinical use of this technique in oral implantology can improve the prognosis...
  44. ncbi Effect of alendronate on endosseous implant integration: an in vivo study in rabbits
    Guillermo E Chacon
    Oral and Maxillofacial Surgery, Section of Oral and Maxillofacial Surgery, Anesthesiology, and Oral and Maxillofacial Pathology, College of Dentistry, The Ohio State University, Columbus, OH, USA
    J Oral Maxillofac Surg 64:1005-9. 2006
    ..The purpose of this study was to determine the effect of systemic alendronate therapy on osseointegration of dental implants based on torque-removal values in rabbits...
  45. ncbi Osseointegration of oxidized and turned implants in circumferential bone defects with and without adjunctive therapies: an experimental study on BMP-2 and autogenous bone graft in the dog mandible
    L A Salata
    Department of Oral and Maxillofacial Surgery and Periodontics, University of Sao Paulo, Faculty of Dentistry of Ribeirao Preto, Ribeirao Preto, Brazil
    Int J Oral Maxillofac Surg 36:62-71. 2007
    ..It is concluded that oxidized implants gain stability more rapidly and integrate with more bone contacts than implants with a turned surface when placed in bone defects...
  46. ncbi Biological responses of anodized titanium implants under different current voltages
    J W Choi
    Department of Prosthodontics and Dental Research Institute, College of Dentistry, Seoul National University, Chongno Gu, Seoul, Korea
    J Oral Rehabil 33:889-97. 2006
    ..05) after a 1-month healing period. In histomorphometric analysis, groups III and IV, after a 3-month healing period, showed greater bone to implant contact ratios for the total implant surface than did group I (P < 0.05)...
  47. ncbi In vitro and in vivo performance of a novel surface treatment to enhance osseointegration of endosseous implants
    Roberto Chiesa
    Department of Chemistry, Materials, and Chemical Engineering G Natta, Polyitecnico di Milano, Milan, Italy
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103:745-56. 2007
    ..This article shows the in vitro and in vivo characterization of a new biomimetic treatment developed to enhance the osseointegration of titanium dental implants...
  48. ncbi The influence of BMP-2 and its mode of delivery on the osteoconductivity of implant surfaces during the early phase of osseointegration
    Yuelian Liu
    ITI Research Institute for Dental and Skeletal Biology, University of Bern, Murtenstrasse 35, P O Box 54, 3010 Bern, Switzerland
    Biomaterials 28:2677-86. 2007
    ..Hence, the osteoconductivity of implant surfaces can be significantly modulated by BMP-2 and its mode of delivery...
  49. ncbi In vivo expression of osteogenic markers and bone mineral density at the surface of fluoride-modified titanium implants
    Marta Monjo
    Department of Biomaterials, Institute for Clinical Dentistry, University of Oslo, Blindern, Oslo, Norway
    Biomaterials 29:3771-80. 2008
    ....
  50. ncbi Surface engineering of titanium by collagen immobilization. Surface characterization and in vitro and in vivo studies
    M Morra
    Nobil Bio Ricerche, Str S Rocco 36, 14018 Villafranca d Asti, Italy
    Biomaterials 24:4639-54. 2003
    ....
  51. ncbi Analysing the optimal value for titanium implant roughness in bone attachment using a tensile test
    H J Rønold
    Department of Prosthetic Dentistry and Oral Function, Dental Faculty, University of Oslo, P O Box 1109 Blindern, N 0317 Oslo, Norway
    Biomaterials 24:4559-64. 2003
    ..62 and 3.90 microm and that a further attachment depended on mechanical interlocking between bone and implant...
  52. ncbi Synchrotron X-ray microtomography (on a micron scale) provides three-dimensional imaging representation of bone ingrowth in calcium phosphate biomaterials
    P Weiss
    Laboratoire de Recherche sur les Matériaux d Intérêt Biologique INSERM 99 03, Faculte de Chirurgie Dentaire, 1 Place Alexis Ricordeau, 44042 Nantes Cedex 01, France
    Biomaterials 24:4591-601. 2003
    ..This 3D study relates the different types of bone substitution to biomaterial architecture. As porosity and interconnection increase, bone ingrowth becomes greater at the expense of the bone substitute: IBS>MBCP>CPC...
  53. ncbi Effects of ion beam-assisted deposition of hydroxyapatite on the osseointegration of endosseous implants in rabbit tibiae
    Y C Jung
    Department of Dentistry, St Vincent's Hospital, School of Medicine, The Catholic University of Korea, Seoul
    Int J Oral Maxillofac Implants 16:809-18. 2001
    ..05)...
  54. ncbi Application of oxygen ion implantation to titanium surfaces: effects on surface characteristics, corrosion resistance, and bone response
    T Sawase
    Department of Biomaterials, Handicap Research Institute for Surgical Sciences, , , Sweden
    Clin Implant Dent Relat Res 3:221-9. 2001
    ..CONCLUSIONS: The results indicate that in spite of improved corrosion resistance in vitro, a thick oxide layer fabricated with the PSII method does not influence early bone formation around titanium implants in vivo...
  55. ncbi Repair of segmental long bone defect in rabbit femur using bioactive titanium cylindrical mesh cage
    Shunsuke Fujibayashi
    Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kawahara cho 54, Sakyo ku, Kyoto 606 8507, Japan
    Biomaterials 24:3445-51. 2003
    ..New bone bonded to the BAT surface without an intervening layer. The BAT cage enhanced the bone repairing process and achieved faster repair of long bone segmental defects...
  56. ncbi Effect of calcium phosphate surface coating on bone ingrowth onto porous-surfaced titanium alloy implants in rabbit tibiae
    Cheng Yang
    Stomatology Center, Union Hospital, People s Republic of China
    J Oral Maxillofac Surg 60:422-5; discussion 426. 2002
    ..The purpose of the present study was to determine whether calcium phosphate coating has a significant impact on bone ingrowth into a porous titanium implant...
  57. ncbi Effect of RGD peptide coating of titanium implants on periimplant bone formation in the alveolar crest. An experimental pilot study in dogs
    Henning Schliephake
    Department of Oral and Maxillofacial Surgery, University Medical School, Hannover, Germany
    Clin Oral Implants Res 13:312-9. 2002
    ..The results therefore require further verification in a modified experimental setting...
  58. ncbi Examination of the bone-metal interface of titanium implants coated by the microwave plasma chemical vapor deposition method
    Stephan Rupprecht
    Department of Oral and Craniomaxillofacial Surgery, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Int J Oral Maxillofac Implants 17:778-85. 2002
    ..In an experimental study using 40 New Zealand White rabbits, a new method for coating implant material was tested for stability of the bone-metal interface...
  59. ncbi Hierarchically biomimetic bone scaffold materials: nano-HA/collagen/PLA composite
    S S Liao
    Biomaterials Laboratory, Department of Material Science and Engineering, Tsinghua University, Beijing 100084, People s Republic of China
    J Biomed Mater Res B Appl Biomater 69:158-65. 2004
    ..This scaffold composite has promise for the clinical repair of large bony defects according to the principles of bone tissue engineering...
  60. ncbi In vivo bone tissue response to a canasite glass-ceramic
    V M da Rocha Barros
    Department of Oral Surgery, University of Sao Paulo, Ribeirao Preto, Brazil
    Biomaterials 23:2895-900. 2002
    ..Further work is required to improve the biocompatibility of these materials with bone tissue. It is possible that this could be achieved by reducing the solubility of the glass and glass ceramic...
  61. ncbi In vivo evaluation of hydroxyapatite foams
    P Sepulveda
    Instituto de Pesquisas Energéticas e Nucleares, IPEN CNEN, Cidade Universitaria, C P 11049 Pinheiros, 05542 970 São Paulo, SP, Brazil
    J Biomed Mater Res 62:587-92. 2002
    ..The high osteoconductive potential of the HA foams provides a potential structure for use as bone substitute in orthopedic, oral, and cranio-maxillofacial reconstructive surgery, and as dento-alveolar implants...
  62. ncbi Bone response to zirconia ceramic implants: an experimental study in rabbits
    Antonio Scarano
    Dental School, University of Chieti, Chieti, Italy
    J Oral Implantol 29:8-12. 2003
    ..No inflamed or multinucleated cells were present. This study concluded that these implants are highly biocompatible and osteoconductive...
  63. ncbi Oxidized, bioactive implants are rapidly and strongly integrated in bone. Part 1--experimental implants
    Young Taeg Sul
    Department of Biomaterials Handicap Research, Institute for Surgical Sciences, Goteborg University, Box 412, S 405 30 Goteborg, Sweden
    Clin Oral Implants Res 17:521-6. 2006
    ..The study presented was designed to investigate the speed and the strength of osseointegration of oxidized implants at early healing times in comparison which machined, turned implants...
  64. ncbi Chronological changes in the ultrastructure of titanium-bone interfaces: analysis by light microscopy, transmission electron microscopy, and micro-computed tomography
    Kenzo Morinaga
    Department of Oral Rehabilitation, Fukuoka Dental College, 2 15 1 Tamura, Sawara ku, Fukuoka, 814 0193, Japan
    Clin Implant Dent Relat Res 11:59-68. 2009
    ..The objectives of this study were to chronologically examine the titanium-bone interfaces and to clarify the process of osseointegration using light microscopy, transmission electron microscopy (TEM), and micro-computed tomography (CT)...
  65. ncbi Ultrastructure of the interface between titanium and surrounding tissue in rat tibiae--a comparison study on titanium-coated and -uncoated plastic implants
    Kae Okamatsu
    Department of Oral Rehabilitation, Fukuoka Dental College, 2 15 1 Tamura, Swara ku, Fukuoka, 814 0193, Japan
    Clin Implant Dent Relat Res 9:100-11. 2007
    ....
  66. ncbi Peri-implant tissue response to TiO2 surface modified implants
    Sami Rossi
    Department of Oral and Maxillofacial Surgery, Institute of Dentistry, University of Turku, Finland
    Clin Oral Implants Res 19:348-55. 2008
    ..The objective of this study was to evaluate peri-implant soft tissue attachment and alveolar bone height on nanoporous TiO(2) thin film on commercial titanium dental implants compared with unmodified standard implants...
  67. ncbi Recombinant human transforming growth factor beta-1 and its effects on osseointegration
    Cameron M L Clokie
    Faculty of Dentistry, University of Toronto, 124 Edward Street, Toronto, Ontario, Canada M5G 2C4
    J Craniofac Surg 14:268-77. 2003
    ..The mean pull-out force for experimental implants was 1,124.01 N and 818.12 N (P = 0.5015) for controls...
  68. ncbi Androgen-induced changes in the response dynamics of ampullary electrosensory primary afferent neurons
    J A Sisneros
    Department of Biological Sciences, Florida Institute of Technology, Melbourne, Florida 32901, USA
    J Neurosci 20:8586-95. 2000
    ..01 to 4 Hz. Experimental implants of dihydrotestosterone in male stingrays induced a similar lowered BF and bandpass and increased average ..
  69. pmc Microvascular maturity elicited in tissue treated with cytokine-loaded hyaluronan-based hydrogels
    Luke W Hosack
    Department of Chemical Engineering, Oregon State University, 102 Gleeson Hall, Corvallis, OR 97331 2702, United States
    Biomaterials 29:2336-47. 2008
    ..The same general trends were found to exist in tissue treated with HA:Hp:Gtn experimental implants. Differences in elicited maturity also existed between tissue treated with HA:Hp and HA-containing ..
  70. ncbi Histological comparison of bone to implant contact in two types of dental implant surfaces: a single case study
    Jamil Awad Shibli
    Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos, SP, Brazil
    J Contemp Dent Pract 8:29-36. 2007
    ..The purpose of this single case study was to evaluate the influence of different implant surfaces on human bone and osseointegration...
  71. ncbi Bone response to endosseous titanium implants surface-modified by blasting and chemical treatment: a histomorphometric study in the rabbit femur
    Jin Woo Park
    Department of Periodontology, College of Dentistry, Kyungpook National University, 188 1, Samduk 2Ga, Jung Gu, Daegu 700 412, South Korea
    J Biomed Mater Res B Appl Biomater 84:400-7. 2008
    ..The experimental implants had submicron-scale porous surface structure consisted of anatase and rutile phase, and the original R(a) ..
  72. ncbi Ultrastructural alterations of polytetrafluoroethylene prostheses implanted in abdominal wall provoked by infection: clinical and experimental study
    J M Bellon
    Department of Morphological Sciences and Surgery, Faculty of Medicine, University of Alcala de Henares, Crta Madrid Barcelona, Spain
    World J Surg 24:528-31; discussion 532. 2000
    ..b>Experimental implants of ePTFE Soft Tissue Patch were performed to repair defects (7 x 5 cm) created in the abdominal wall of 10 ..
  73. ncbi Evaluation of osseointegration of dental implants coated with collagen, chondroitin sulphate and BMP-4: an animal study
    B Stadlinger
    Department of Maxillofacial Surgery, Faculty of Medicine, University of Technology Dresden, Fetscherstr 74, D 01307 Dresden, Germany
    Int J Oral Maxillofac Surg 37:54-9. 2008
    ..The experimental implants had two recesses along the length axis...
  74. ncbi Bone-to-implant apposition with machined and MTX microtextured implant surfaces in human sinus grafts
    Paolo Trisi
    Biomaterials Clinical Research Association, Pescara, Italy
    Int J Periodontics Restorative Dent 23:427-37. 2003
    ..In addition to the conventional dental implants selected for each case, titanium alloy experimental implants, 2.5 mm in diameter and 8 mm in length, were custom manufactured...
  75. ncbi Increased bone formation around coated implants
    Bernd Stadlinger
    Department of Oral and Maxillofacial Surgery, Faculty of Medicine, University of Technology Dresden, Dresden, Germany
    J Clin Periodontol 36:698-704. 2009
    ..We hypothesized that coating threaded, sandblasted acid-etched titanium implants with collagen and chondroitin sulphate (CS) increases bone formation and implant stability, compared with uncoated controls...
  76. ncbi Bone regeneration of critical calvarial defect in goat model by PLGA/TCP/rhBMP-2 scaffolds prepared by low-temperature rapid-prototyping technology
    D Yu
    Department of Plastic and Reconstructive Surgery, Shanghai Ninth People s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
    Int J Oral Maxillofac Surg 37:929-34. 2008
    ..The scaffold has a good three-dimensional structure and it becomes an active artificial bone after loading with rhBMP-2 with a modest degradation rate and excellent osteogenesis in the goat...
  77. ncbi Osteoconductivity of hydrophilic microstructured titanium implants with phosphate ion chemistry
    Jin Woo Park
    Department of Metals, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Japan
    Acta Biomater 5:2311-21. 2009
    ..The osteoconductivity of experimental implants was evaluated by removal torque testing and histomorphometric analysis after 6 weeks of implantation in ..
  78. ncbi Implant placement in fresh extraction sockets and simultaneous osteotome sinus floor elevation: a case series
    Antonio Barone
    Department of Oral Pathology, Nanoword Institute, School of Dental Medicine, University of Genova, Italy
    Int J Periodontics Restorative Dent 28:283-9. 2008
    ..All implants were allowed to heal for 6 months prior to prosthetic rehabilitation. One of the 12 experimental implants failed because of an abscess during early healing...
  79. ncbi Enhanced bone apposition to a chemically modified SLA titanium surface
    D Buser
    Department of Oral Surgery and Stomatology, School of Dental Medicine, University of Berne, Freiburgstrasse 7, PO Box 64, 3010 Berne, Switzerland
    J Dent Res 83:529-33. 2004
    ..b>Experimental implants were placed in miniature pigs, creating 2 circular bone defects...
  80. ncbi Composite tissue formation derived solely from a blood biological matrix: a preliminary study
    M P Vacanti
    Laboratory for Tissue Engineering, The Department of Otolaryngology Head and Neck Surgery, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Transplant Proc 40:1696-9. 2008
    ..Histological analysis of the experimental implants showed a composite tissue formation consisting of neural tissue, bone, and cartilage similar in cellular ..
  81. pmc Engineering endochondral bone: in vivo studies
    Serafim M Oliveira
    Department of Mechanical Engineering, ESTV Escola Superior de Tecnologia de Viseu, Viseu, Portugal
    Tissue Eng Part A 15:635-43. 2009
    ..The deposition of ectopic bone was detected in the surface of the experimental implants as early as 1 month after implantation...
  82. ncbi Immediate implant placement into infected and noninfected extraction sockets: a pilot study
    Seok Woo Chang
    Department of Conservative Dentistry, The Institute of Oral Health Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwondong, Gangnamgu, Seoul, Korea
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 107:197-203. 2009
    ..This study compared the osseointegration of immediate implants in dogs in infection-free sites and in sites with periradicular lesions which were removed by simulated periradicular surgery...
  83. ncbi Influence of the length of the loading period after placement of orthodontic mini-implants on changes in bone histomorphology: microcomputed tomographic and histologic analysis
    Jung Yul Cha
    Department of Orthodontics, College of Dentistry, Yonsei University, Seoul, South Korea
    Int J Oral Maxillofac Implants 24:842-9. 2009
    ....
  84. ncbi The effects of laser microtextured collars upon crestal bone levels of dental implants
    Saul Weiner
    Department of Restorative Dentistry, New Jersey Dental School, Newark, NJ 07101 1709, USA
    Implant Dent 17:217-28. 2008
    ..The purpose of this study was to examine the crestal bone, connective tissue, and epithelial cell response to a laser microtextured collar compared with a machined collar, in the dog model...
  85. ncbi Glycolic acid modulates the mechanical property and degradation of poly(glycerol, sebacate, glycolic acid)
    Zhi Jie Sun
    Center for Biomedical Materials and Engineering, Harbin Engineering University, Harbin 150001, People s Republic of China
    J Biomed Mater Res A 92:332-9. 2010
    ..All PGSG samples displayed good tissue response and anticoagulant effects. Our data suggest that doping glycolic acid can modulate the microstructure and degree of crosslinking of PGS, thereby control the degradation rate of PGS...
  86. ncbi The diameter of anodic TiO2 nanotubes affects bone formation and correlates with the bone morphogenetic protein-2 expression in vivo
    Cornelius von Wilmowsky
    Department of Oral and Maxillofacial Surgery, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Clin Oral Implants Res 23:359-66. 2012
    ..Therefore, the aim of the present study was to investigate the effects of the diameter of TiO2 nanotubes on peri-implant bone formation and the expression of bone matrix proteins in vivo...
  87. ncbi Experimental study of bone response to a new surface treatment of endosseous titanium implants
    A Sanz
    Odontology Faculty, University of Chile, Santiago, Chile
    Implant Dent 10:126-31. 2001
    ..Further studies with a larger sample size are needed to confirm these initial findings...
  88. ncbi Artificial biological ligament: its making, testing, and experimental study on animals
    Kun Wang
    Department of Orthopedics, Third Affiliated Hospital of Sun Yat Sen University, Guangzhou, China
    Microsurgery 28:44-53. 2008
    ..As a substitute for ligament in the reconstruction of the ACL, ABL has a promising prospect in clinical applications...
  89. ncbi Osteoinduction of hydroxyapatite/beta-tricalcium phosphate bioceramics in mice with a fractured fibula
    Lijia Cheng
    Key Laboratory of Transplant Engineering and Immunology, Ministry of Health, West China Hospital, Sichuan University, Chengdu, People s Republic of China
    Acta Biomater 6:1569-74. 2010
    ..The results support the hypothesis that intrinsic osteoinduction by calcium phosphate ceramics is the result of adsorption of osteoinductive substances on the surface...
  90. ncbi Laminated and functionally graded hydroxyapatite/yttria stabilized tetragonal zirconia composites fabricated by spark plasma sintering
    Hongbo Guo
    School of Materials Engineering, Nanyang Technological University, Nanyang Avenue, Singapore 639798, Singapore
    Biomaterials 24:667-75. 2003
    ....
  91. ncbi Effect of meloxicam and diclofenac sodium on peri-implant bone healing in rats
    Alethéia B Pablos
    Department of Implantology, São Leopoldo Mandic Dental Research Center, Campinas, SP, Brazil
    J Periodontol 79:300-6. 2008
    ..This study evaluated the effects of diclofenac sodium and meloxicam on peri-implant bone healing...
  92. ncbi Soft tissue response of the rabbit larynx to Gore-Tex implants
    Steve Cashman
    Department of Otolaryngology Head and Neck Surgery, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284 7777, USA
    Ann Otol Rhinol Laryngol 111:977-82. 2002
    ..Foreign body giant cells were observed at the interface of the implant with the tissue. No migration or extrusion of the implant was observed. These results suggest that Gore-Tex is biocompatible in the rabbit larynx...
  93. ncbi Validating the subcutaneous model of injectable autologous cartilage using a fibrin glue scaffold
    R Westreich
    Department of Otolaryngology, Mount Sinai Hospital, 1 Gustave L Levy Place, Annanberg 10th Floor, New York, NY 10029, U S A
    Laryngoscope 114:2154-60. 2004
    ..To create and validate an injectable model for autologous in vivo cartilage engineering with ultimate clinical applicability in human subjects...
  94. ncbi [Evaluation of the value of local protective methods using latex prosthesis and fibrin glue in colonic anastomoses]
    G Stanojevic
    Hirurska klinika Klinicki centar Nis
    Acta Chir Iugosl 50:35-41. 2003
    ..The results of this experiment demonstrate that local protective measures for colon anastomoses may produce better results, with fibrine adhesive administration as the best modality...
  95. ncbi Long-term in vivo biomechanical properties and biocompatibility of poly(2-hydroxyethyl methacrylate-co-methyl methacrylate) nerve conduits
    Jason S Belkas
    Division of Neurosurgery and Neuroscience Research Program, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Toronto, Ont, Canada, M4N 3M5
    Biomaterials 26:1741-9. 2005
    ..Tubes also demonstrated signs of calcification, which increased from 8 to 16 weeks. To overcome these issues, future nerve conduits will be re-designed to be more robust and biocompatible...
  96. ncbi Tissue reactions of in situ formed dextran hydrogels crosslinked by stereocomplex formation after subcutaneous implantation in rats
    Gert W Bos
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, P O Box 80 082, 3508 TB Utrecht, The Netherlands
    Biomaterials 26:3901-9. 2005
    ..In conclusion, stereocomplexed dextran-oligolactic gels showed good biocompatibility which makes them suitable candidates for the design of controlled release devices for pharmaceutically active proteins...
  97. ncbi Platelet rich plasma and fresh frozen bone allograft as enhancement of implant fixation. An experimental study in dogs
    T B Jensen
    Orthopaedic Research Group, Institute of Experimental Clinical Research, Aarhus University Hospital, Aarhus Kommunehospital, 8000 Aarhus C, Denmark
    J Orthop Res 22:653-8. 2004
    ..More studies are needed to investigate the effect and possible clinical applications of platelet concentrates which are now being commercialised...
  98. ncbi [Experimental research on degradation and biocompatibility of super-high-molecular-weight poly-DL-lactic acid]
    Lei Liu
    West China College of Stomatology, Sichuan University
    Hua Xi Kou Qiang Yi Xue Za Zhi 20:216-8. 2002
    ....
  99. ncbi Osseointegration of Osseotite and machined titanium implants in autogenous bone graft. A histologic and histomorphometric study in dogs
    Alexander A Veis
    Department of Surg Implantology and Roedgenology, Dental School, Aristotle s University of Thessaloniki, Greece
    Clin Oral Implants Res 15:54-61. 2004
    ..32+/-15.09% vs. 17.25+/-7.40%). The findings of this study imply that the use of autogenous bone graft resulted in significantly higher %BIC values in the regenerated area than in the basal bone area itself, for both implant surfaces...
  100. ncbi Rabbit calvarial wound healing by means of seeded Caprotite scaffolds
    S M S Bidic
    Plastic Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Dent Res 82:131-5. 2003
    ..Results suggest that seeded Caprotite scaffolds did not significantly enhance osseous defect healing compared with controls...
  101. ncbi Generation of microdamage around endosseous implants
    Abdulhadi Warreth
    Department of Restorative Dentistry and Periodontology, Trinity College, School of Dental Science, Dublin, Ireland
    Clin Oral Implants Res 20:1300-6. 2009
    ..The aim of this study was to investigate the occurrence of microdamage as a result of osteotomy preparation and/or insertion of endosseous screw-shaped titanium implants into the dog mandible...

Research Grants35

  1. BIOMEDICAL RESEARCH SUPPORT
    Donald Bers; Fiscal Year: 1991
    ..of the surface structure and composition (outermost 50A) of synthetic materials used in clinical and experimental implants, adsorbed protein films, and cell surfaces...
  2. Periodontal Disease and Rheumatoid Arthritis
    Michael McCracken; Fiscal Year: 2005
    ..Furthermore, it is hypothesized that among patients with rheumatoid arthritis, an association exists between the rate of progression of inflammatory arthritis and the progression of periodontal disease. ..
  3. 8th Conference - Chemistry & Biology Mineralized Tissue
    WILLIAM LANDIS; Fiscal Year: 2004
    ....
  4. MINERAL-MATRIX RELATIONS IN CALCIFYING TISSUES
    WILLIAM LANDIS; Fiscal Year: 2006
    ....
  5. Mineral and Mechanical Properties of Bone
    Sarandeep Huja; Fiscal Year: 2005
    ..Future interventional studies will examine the mechanisms for the initial and the long-term adaptive response in material properties of bone. ..
  6. Effect of Diabetes on Bone Integration of Implants
    Michael McCracken; Fiscal Year: 2002
    ..This knowledge may lead to bioengineered materials which will modify and improve bone healing response in diabetic patients who receive implants. ..
  7. TREATMENT OF AORTIC ANEURYSMS
    Naren Vyavahare; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  8. Detection of Live Fibers in Injured Spinal Cord
    Mehmet Bilgen; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  9. Skin Adaptation to Mechanical Stress
    Joan Sanders; Fiscal Year: 2006
    ..By understanding the process of skin adaptation (natural skin strengthening) at both a cellular and molecular level, therapies to encourage skin adaptation before breakdown occurs can be intelligently pursued. ..
  10. INTERFACE MECHANICS, MATERIALS AND TISSUE RESPONSE
    Joan Sanders; Fiscal Year: 2007
    ..The development of methods to predict and overcome the detrimental effects of residual limb shape change and ultimately prevent soft-tissue breakdown will help to prevent secondary disability and morbidity in the amputee population. ..
  11. Assessment of Tissue Response to Stress
    Joan Sanders; Fiscal Year: 2006
    ..this technology could be applied to other areas of rehabilitation, for example, shoe design for patients with insensate feet, cushion design for wheelchair users, and mattress design for bedridden patients [unreadable] [unreadable]..
  12. Calcification of Elastin: Mechanisms and Prevention
    Naren Vyavahare; Fiscal Year: 2008
    ..Long-term objective of our program is to understand the mechanistic pathways of elastin calcification so that it can be prevented or reversed. The following specific aims will be pursued in this continuation program. ..
  13. Diabetes: Implant Integration, Success, and Benefit
    Thomas W Oates; Fiscal Year: 2010
    ..Ultimately, this information will contribute to the establishment of evidence-based guidelines for the assessment and application of dental implant therapy for patients with diabetes. ..
  14. The Role of P4H in Tissue-Titanium Integration
    Takahiro Ogawa; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  15. Thromboresistant vascular grafts:heparin-peptidomimetics
    PAUL ZAMORA; Fiscal Year: 2004
    ..abstract_text> ..
  16. FGF-Silyl-Heparin Cerebral Aneurysm Coils
    PAUL ZAMORA; Fiscal Year: 2002
    ..The Phase I studies will develop the coated coils and perform initial animal evaluations. ..
  17. INTERFACE MECHANICS, MATERIALS, AND TISSUE RESPONSE
    Joan Sanders; Fiscal Year: 2003
    ....
  18. Osteoblast response to strain at implant-tissue interfac
    Joel Bumgardner; Fiscal Year: 2003
    ..Furthermore, it may also be useful in identifying loading parameters that promote osteointegration. ..
  19. Cell phenotype-controlled mechanical signaling of MSCs
    David Butler; Fiscal Year: 2004
    ..This technology can dramatically reduce time/expense during the development phase of TE fibrocartilage. ..
  20. Intracortical Visual Prothesis
    Philip Troyk; Fiscal Year: 2002
    ..6. Establish criteria for proceeding to a future human implantation using a thorough multi-faceted examination of ethical and psychological issues. ..
  21. INTERFACE MECHANICS, MATERIALS, AND TISSUE RESPONSE
    Joan Sanders; Fiscal Year: 2002
    ....
  22. Robotic Simulation: Tissue Function with In Vivo Motions
    David Butler; Fiscal Year: 2007
    ..These technologies will serve as a platform for studying injury, repair and reconstruction in the knee and other joints and to develop functional tissue engineering parameters. [unreadable] [unreadable] [unreadable]..
  23. 2006 Summer Bioengineering Conference
    Vijay Goel; Fiscal Year: 2006
    ..This should help create the necessary work force of varied interests in the health care field. [unreadable] [unreadable] [unreadable]..
  24. NEW BIOMATERIALS TO MINIMIZE SCAR TISSUE FORMATION
    Joan Sanders; Fiscal Year: 2002
    ..e. soft-tissue complications that require surgical repair through use of a biomaterial. The new materials will prevent scar tissue formation and reduce the occurrence of secondary complications. ..
  25. Intracortical Visual Prothesis
    Philip Troyk; Fiscal Year: 2005
    ..6. Establish criteria for proceeding to a future human implantation using a thorough multi-faceted examination of ethical and psychological issues. ..
  26. Estrogen: Chrodroprotective or Destructive?
    Sally Frenkel; Fiscal Year: 2002
    ..The inconclusive and contradictory data from human and animal studies render the proposed studies highly significant. ..
  27. Vascular plasticity in Injured Spinal Cord - Investigations using MRI
    Mehmet Bilgen; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  28. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    HECTOR MOBINE; Fiscal Year: 2008
    ..The findings may not only afford further appreciation of the pathophysiology and etiology of peripartum cardiomyopathy but also of general mechanisms in disease progression. [unreadable] [unreadable] [unreadable]..
  29. "In Vitro Mechanical Stimulation to Enhance Tendon Repair"
    David Butler; Fiscal Year: 2009
    ..Our novel, interactive in vitro / in vivo study should help to develop in vitro predictors of in vivo repair outcome after surgery that also apply to other tissue systems. ..
  30. SYSTEMATIC EVALUATION OF THE PLASMINOGEN SYSTEM
    Jane Hoover Plow; Fiscal Year: 2003
    ..End of Abstract.) ..
  31. Tissue Engineering Evaluation Criteria for Musculoskeletal Tissue Repair
    David Butler; Fiscal Year: 2007
    ..abstract_text> ..
  32. CAN CD 133 CELLS PREVENT HYPOXIA DRIVEN RETINAL NEOVASCULARISATION IN A RODENT MO
    Bela Anand Apte; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  33. Inhibition of VEGF Mediated Angiogenesis by TIMP-3
    Bela Anand Apte; Fiscal Year: 2009
    ..2. To determine the potential role of heparin/heparan sulfate binding on the angiostatic activity of TIMP-3. 3. To determine the VEGF mediated angiogenic response and tumor growth in TIMP-3 null mice. ..
  34. REGULATION OF RETINAL NEOVASCULARIZATION BY TIMP3
    Bela Anand Apte; Fiscal Year: 2002
    ..The broad long term goal of this proposal is to gain an understanding of the mechanism(s) by which alterations in matrix integrity may regulate retinal neovascularization using TIMP-3 mutations in SFD as a model. ..
  35. Role of TIMP-3 in Ocular Neovascularization
    Bela Anand Apte; Fiscal Year: 2009
    ..a) Do mice expressing S156C TIMP-3 show increased angiogenic responses to VEGF? b) What are the molecular mechanisms by which S156C TIMP-3 accentuates VEGF mediated angiogenesis? ..