cochlear implants

Summary

Summary: Electronic hearing devices typically used for patients with normal outer and middle ear function, but defective inner ear function. In the COCHLEA, the hair cells (HAIR CELLS, VESTIBULAR) may be absent or damaged but there are residual nerve fibers. The device electrically stimulates the COCHLEAR NERVE to create sound sensation.

Top Publications

  1. ncbi The influence of a sensitive period on central auditory development in children with unilateral and bilateral cochlear implants
    Anu Sharma
    Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX, USA
    Hear Res 203:134-43. 2005
  2. pmc The development of the Nucleus Freedom Cochlear implant system
    James F Patrick
    Cochlear Limited, Lane Cove, New South Wales, Australia
    Trends Amplif 10:175-200. 2006
  3. pmc Language development in profoundly deaf children with cochlear implants
    M A Svirsky
    Indiana University School of Medicine, Department of Otolaryngology Head and Neck Surgery, 702 Barnhill Dr, RR 044, Indianapolis, IN 46202 5200, USA
    Psychol Sci 11:153-8. 2000
  4. ncbi Clinical evaluation of signal-to-noise ratio-based noise reduction in Nucleus® cochlear implant recipients
    Pam W Dawson
    The HEARing Cooperative Research Centre, and 2Cochlear Limited, Melbourne, Victoria, Australia
    Ear Hear 32:382-90. 2011
  5. ncbi McGurk effects in cochlear-implanted deaf subjects
    Julien Rouger
    Centre de Recherche Cerveau et Cognition, UMR CNRS 5549, Faculte de Medecine de Rangueil, Toulouse Cedex 9, France
    Brain Res 1188:87-99. 2008
  6. pmc Working memory training for children with cochlear implants: a pilot study
    William G Kronenberger
    Riley Child and Adolescent Psychiatry Clinic Department of Psychiatry, Indianapolis, IN, USA
    J Speech Lang Hear Res 54:1182-96. 2011
  7. ncbi Combining directional microphone and single-channel noise reduction algorithms: a clinical evaluation in difficult listening conditions with cochlear implant users
    Adam A Hersbach
    Cochlear Ltd, 174 Victoria Parade, East Melbourne, Australia 3002
    Ear Hear 33:e13-23. 2012
  8. ncbi Cochlear implant speech recognition with speech maskers
    Ginger S Stickney
    University of California, Department of Otolaryngology Head and Neck Surgery, Irvine, California 92697 1275, USA
    J Acoust Soc Am 116:1081-91. 2004
  9. ncbi Cognitive and linguistic skills in Swedish children with cochlear implants - measures of accuracy and latency as indicators of development
    Malin Wass
    The Swedish Institute for Disability Research, Linkoping, Sweden
    Scand J Psychol 49:559-76. 2008
  10. ncbi Music perception in adult cochlear implant recipients
    Mariana C Leal
    Department of Otolaryngology, Purpan Hospital, Toulouse, France
    Acta Otolaryngol 123:826-35. 2003

Research Grants

Detail Information

Publications292 found, 100 shown here

  1. ncbi The influence of a sensitive period on central auditory development in children with unilateral and bilateral cochlear implants
    Anu Sharma
    Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX, USA
    Hear Res 203:134-43. 2005
    ..development of the cortical auditory evoked potential (CAEP) in 21 children who were fitted with unilateral cochlear implants and in two children who were fitted with bilateral cochlear implants either before age 3...
  2. pmc The development of the Nucleus Freedom Cochlear implant system
    James F Patrick
    Cochlear Limited, Lane Cove, New South Wales, Australia
    Trends Amplif 10:175-200. 2006
    ..Included are studies showing the benefits from bilateral implants, electroacoustic stimulation using an ipsilateral and/or contralateral hearing aid, advanced speech coding, and streamlined speech processor programming...
  3. pmc Language development in profoundly deaf children with cochlear implants
    M A Svirsky
    Indiana University School of Medicine, Department of Otolaryngology Head and Neck Surgery, 702 Barnhill Dr, RR 044, Indianapolis, IN 46202 5200, USA
    Psychol Sci 11:153-8. 2000
    Although cochlear implants improve the ability of profoundly deaf children to understand speech, critics claim that the published literature does not document even a single case of a child who has developed a linguistic system based on ..
  4. ncbi Clinical evaluation of signal-to-noise ratio-based noise reduction in Nucleus® cochlear implant recipients
    Pam W Dawson
    The HEARing Cooperative Research Centre, and 2Cochlear Limited, Melbourne, Victoria, Australia
    Ear Hear 32:382-90. 2011
    ..The aim of this study was to investigate whether a real-time noise reduction algorithm provided speech perception benefit for Cochlear™ Nucleus® cochlear implant recipients in the laboratory...
  5. ncbi McGurk effects in cochlear-implanted deaf subjects
    Julien Rouger
    Centre de Recherche Cerveau et Cognition, UMR CNRS 5549, Faculte de Medecine de Rangueil, Toulouse Cedex 9, France
    Brain Res 1188:87-99. 2008
    b>Cochlear implants are neuroprostheses designed to restore speech perception in case of profound bilateral hearing loss...
  6. pmc Working memory training for children with cochlear implants: a pilot study
    William G Kronenberger
    Riley Child and Adolescent Psychiatry Clinic Department of Psychiatry, Indianapolis, IN, USA
    J Speech Lang Hear Res 54:1182-96. 2011
    This study investigated the feasibility and efficacy of a working memory training program for improving memory and language skills in a sample of 9 children who are deaf (age 7-15 years) with cochlear implants (CIs).
  7. ncbi Combining directional microphone and single-channel noise reduction algorithms: a clinical evaluation in difficult listening conditions with cochlear implant users
    Adam A Hersbach
    Cochlear Ltd, 174 Victoria Parade, East Melbourne, Australia 3002
    Ear Hear 33:e13-23. 2012
    ..A noise reduction (NR) algorithm, based on signal to noise ratio estimation was evaluated in combination with several directional microphone algorithms available in the Cochlear CP810 sound processor...
  8. ncbi Cochlear implant speech recognition with speech maskers
    Ginger S Stickney
    University of California, Department of Otolaryngology Head and Neck Surgery, Irvine, California 92697 1275, USA
    J Acoust Soc Am 116:1081-91. 2004
    ..This informational masking may originate from increased target-masker similarity when spectral resolution is reduced...
  9. ncbi Cognitive and linguistic skills in Swedish children with cochlear implants - measures of accuracy and latency as indicators of development
    Malin Wass
    The Swedish Institute for Disability Research, Linkoping, Sweden
    Scand J Psychol 49:559-76. 2008
    ..was to examine working memory (WM) capacity, lexical access and phonological skills in 19 children with cochlear implants (CI) (5;7-13;4 years of age) attending grades 0-2, 4, 5 and 6 and to compare their performance with 56 ..
  10. ncbi Music perception in adult cochlear implant recipients
    Mariana C Leal
    Department of Otolaryngology, Purpan Hospital, Toulouse, France
    Acta Otolaryngol 123:826-35. 2003
    ..To evaluate musical perception in adult cochlear implant (CI) recipients, i.e. perceptual accuracy for pitch, timbre, rhythmic patterns and song identification...
  11. pmc Cochlear implants: system design, integration, and evaluation
    Fan Gang Zeng
    Department of Anatomy and Neurobiology, University of California, Irvine, CA 92697, USA
    IEEE Rev Biomed Eng 1:115-42. 2008
    As the most successful neural prosthesis, cochlear implants have provided partial hearing to more than 120000 persons worldwide; half of which being pediatric users who are able to develop nearly normal language...
  12. pmc Maximizing cochlear implant patients' performance with advanced speech training procedures
    Qian Jie Fu
    Department of Auditory Implants and Perception, House Ear Institute, 2100 West Third Street, Los Angeles, CA 90057, USA
    Hear Res 242:198-208. 2008
    ....
  13. pmc Speech recognition with amplitude and frequency modulations
    Fan Gang Zeng
    Department of Anatomy and Neurobiology, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 102:2293-8. 2005
    ..Encoding FM may improve auditory scene analysis, cochlear-implant, and audiocoding performance...
  14. ncbi Phonological processing in post-lingual deafness and cochlear implant outcome
    D S Lazard
    Ecole Normale Superieure, Departement d Etudes Cognitives, INSERM U960, Paris, F 75005, France
    Neuroimage 49:3443-51. 2010
    b>Cochlear implants work well, yet the outcome is not fully accounted by the data routinely available to the clinician, and remains unpredictable...
  15. ncbi Changes over time in electrical stimulation levels and electrode impedance values in children using the Nucleus 24M cochlear implant
    Yael Henkin
    Department of Communication Disorders, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Int J Pediatr Otorhinolaryngol 67:873-80. 2003
    ..e. threshold levels, comfortable levels, dynamic range, and electrode impedance values during the 1st year post-implantation, in children using the Nucleus 24M cochlear implant system...
  16. ncbi Combining acoustic and electrical hearing
    Bruce J Gantz
    Department of Otolaryngology Head and Neck Surgery, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, 21201 PFP, Iowa City IA 52242 1078, USA
    Laryngoscope 113:1726-30. 2003
    ..In addition, whether residual hearing can be preserved when an electrode is placed into the inner ear up to 10 mm and whether place of electrical stimulation influences speech perception were tested...
  17. ncbi Minimization of cochlear implant stimulus artifact in cortical auditory evoked potentials
    Phillip M Gilley
    School of Behavioral and Brain Sciences, Callier Advanced Hearing Research Center, The University of Texas at Dallas, 1966 Inwood Road, 75235, USA
    Clin Neurophysiol 117:1772-82. 2006
    ..To compare two methods of minimizing cochlear implant artifact in cortical auditory evoked potential (CAEP) recordings...
  18. ncbi Analysis of Vibrant Soundbridge placement against the round window membrane in a human cadaveric temporal bone model
    Ronald J E Pennings
    Division of Otolaryngology, Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada
    Otol Neurotol 31:998-1003. 2010
    ..To evaluate optimal placement of the Floating Mass Transducer of the Vibrant Soundbridge (Med-El, Innsbruck, Austria) against the round window membrane, particularly the impact of interposed coupling fascia and of covering materials...
  19. ncbi A new electrode for residual hearing preservation in cochlear implantation: first clinical results
    Wolfgang Gstoettner
    Department of Otorhinolaryngology, Medical University of Vienna, Vienna, Austria
    Acta Otolaryngol 129:372-9. 2009
    ..A so far unattained high rate (100%) of residual hearing preservation in cochlear implantation for electric-acoustic stimulation could be achieved using sophisticated surgical techniques in combination with the MedEl Flex EAS electrode...
  20. ncbi Effectiveness of computer-based auditory training for adult users of cochlear implants
    Paula C Stacey
    Division of Psychology, Nottingham Trent University, Nottingham, UK
    Int J Audiol 49:347-56. 2010
    ..self-administered training package that was designed to improve speech perception among adults who had used cochlear implants for more than three years...
  21. ncbi Temporal processing and speech recognition in cochlear implant users
    Qian Jie Fu
    Department of Auditory Implants and Perception, House Ear Institute, 2100 West Third Street, Los Angeles, CA 90057, USA
    Neuroreport 13:1635-9. 2002
    ..In correlating a basic psychophysical measure to speech performance, these results should contribute toward improved speech processor design and rehabilitation tools for cochlear implant patients...
  22. ncbi Bilateral paediatric cochlear implants: a critical review
    J Cyne Johnston
    University of Ottawa, Ottawa, ON, Canada
    Int J Audiol 48:601-17. 2009
    A recent trend has been the implantation of bilateral cochlear implants (CIs) for children with severe to profound hearing loss. A review of available research on bilateral CIs was conducted to determine the support for this trend...
  23. pmc Pre-, per- and postoperative factors affecting performance of postlinguistically deaf adults using cochlear implants: a new conceptual model over time
    Diane S Lazard
    Bionics Institute, Melbourne, Australia
    PLoS ONE 7:e48739. 2012
    ....
  24. ncbi The age at which young deaf children receive cochlear implants and their vocabulary and speech-production growth: is there an added value for early implantation?
    Carol McDonald Connor
    Florida State University and the Florida Center for Reading Research, Tallahassee, FL 32301, USA
    Ear Hear 27:628-44. 2006
    ..In this study, we investigate whether there is an added value to earlier implantation or whether advantages observed in child outcomes are primarily attributable to longer device use at any given age...
  25. ncbi The round window: is it the "cochleostomy" of choice? Experience in 130 consecutive cochlear implants
    David A Gudis
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Otol Neurotol 33:1497-501. 2012
    ..To demonstrate that the round window insertion (RWI) for cochlear implantation with multichannel electrodes is a reliable, safe, and effective technique...
  26. ncbi Effects of directional microphone and adaptive multichannel noise reduction algorithm on cochlear implant performance
    King Chung
    Department of Speech, Language, and Hearing Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    J Acoust Soc Am 120:2216-27. 2006
    ..Implications for intelligibility enhancement are discussed...
  27. ncbi Development and evaluation of an improved cochlear implant electrode design for electric acoustic stimulation
    Oliver Adunka
    ENT Department, J W Goethe University Frankfurt am Main, Frankfurt am Main, Germany
    Laryngoscope 114:1237-41. 2004
    ..Special emphasis was placed on the practicality for combined electric and acoustic stimulation of the auditory system...
  28. ncbi Cochlear implant programming
    William H Shapiro
    Department of Otolaryngology, NYU Langone Medical Center, 550 First Avenue, New York, NY 10016, USA
    Otolaryngol Clin North Am 45:111-27. 2012
    b>Cochlear implants have become a viable treatment option for individuals who present with severe to profound hearing loss...
  29. ncbi What's to lose and what's to learn: development under auditory deprivation, cochlear implants and limits of cortical plasticity
    Andrej Kral
    Laboratory of Auditory Neuroscience, Department of Neurophysiology and Pathophysiology, University of Hamburg School of Medicine, Germany
    Brain Res Rev 56:259-69. 2007
    ..In consequence, the ability to learn is compromised in sensory deprivation, resulting in a sensitive period for recovery...
  30. ncbi Adaptive dynamic range optimization for cochlear implants: a preliminary study
    Chris J James
    Cooperative Research Centre for Cochlear Implant and Hearing Aid Innovation, The University of Melbourne, Australia
    Ear Hear 23:49S-58S. 2002
    ..ADRO is a preprocessing scheme that continuously adjusts the gain in each frequency band to optimize the signal in the output dynamic range...
  31. pmc Cortical development, plasticity and re-organization in children with cochlear implants
    Anu Sharma
    Brain and Behavior Laboratory, Department of Speech, Language and Hearing Sciences, University of Colorado at Boulder, 2501 Kittredge Loop Road, 409 UCB, Boulder, CO 80309 0409, USA
    J Commun Disord 42:272-9. 2009
    ..will describe age cut-offs for a sensitive period for central auditory development in children who receive cochlear implants. We will review de-coupling and re-organization of cortical areas, which are presumed to underlie the end of ..
  32. ncbi Ipsilateral electric acoustic stimulation of the auditory system: results of long-term hearing preservation
    Wolfgang K Gstoettner
    Department of Otolaryngology, Johann Wolfgang Goethe University Frankfurt am Main, Frankfurt am Main, Germany
    Audiol Neurootol 11:49-56. 2006
    ..To evaluate long-term ipsilateral hearing preservation in patients who underwent cochlear implantation for the combined electric acoustic stimulation of the auditory system...
  33. pmc Effects of stimulation rate, mode and level on modulation detection by cochlear implant users
    John J Galvin
    Department of Auditory Implants and Perception, House Ear Institute, 2100 West Third Street, Los Angeles, CA 90057, USA
    J Assoc Res Otolaryngol 6:269-79. 2005
    ..Lower stimulation rates may provide better recognition of weak acoustic envelope information...
  34. pmc Topographic spread of inferior colliculus activation in response to acoustic and intracochlear electric stimulation
    Russell L Snyder
    Epstein Laboratory, Department of Otolaryngology, University of California, San Francisco, CA 94143 0526, USA
    J Assoc Res Otolaryngol 5:305-22. 2004
    The design of contemporary multichannel cochlear implants is predicated on the presumption that they activate multiple independent sectors of the auditory nerve array...
  35. ncbi Electrophysiological and speech perception measures of auditory processing in experienced adult cochlear implant users
    Andrea S Kelly
    Discipline of Audiology, The University of Auckland, Private Bag 92 019, Auckland, New Zealand
    Clin Neurophysiol 116:1235-46. 2005
    ....
  36. pmc Auditory prosthesis with a penetrating nerve array
    John C Middlebrooks
    Kresge Hearing Research Institute, Department of Otorhinolaryngology, University of Michigan, Ann Arbor, MI 48109 0506, USA
    J Assoc Res Otolaryngol 8:258-79. 2007
    Contemporary auditory prostheses ("cochlear implants") employ arrays of stimulating electrodes implanted in the scala tympani of the cochlea...
  37. pmc Systematic review of the scientific literature on the economic evaluation of cochlear implants in paediatric patients
    G Turchetti
    Management Institute, Scuola Superiore Sant Anna, Pisa, Italy
    Acta Otorhinolaryngol Ital 31:311-8. 2011
    ..Cost analysis, cost-effectiveness analysis and an analysis of educational costs associated with cochlear implants were performed. Regarding the cost analysis, only two articles reported both direct cost and indirect costs...
  38. ncbi Visual activation of auditory cortex reflects maladaptive plasticity in cochlear implant users
    Pascale Sandmann
    Department of Psychology, Neuropsychology Lab, Carl von Ossietzky University of Oldenburg, Germany
    Brain 135:555-68. 2012
    ..Incomplete reversal of this deafness-induced cortical reorganization might limit clinical benefit from a cochlear implant and help explain the high inter-subject variability in auditory speech comprehension...
  39. ncbi Music perception with temporal cues in acoustic and electric hearing
    Ying Yee Kong
    Department of Cognitive Sciences, University of California, Irvine, 92697, USA
    Ear Hear 25:173-85. 2004
    ..The second aim is to identify the relative contribution of temporal and spectral cues to melody recognition in acoustic and electric hearing...
  40. ncbi Hearing after congenital deafness: central auditory plasticity and sensory deprivation
    A Kral
    Physiologisches Institut II, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Cereb Cortex 12:797-807. 2002
    ..The data emphasize that young sensory systems in cats have a higher capacity for plasticity than older ones and that there is a sensitive period for the cat's auditory system...
  41. pmc Effects of carrier pulse rate and stimulation site on modulation detection by subjects with cochlear implants
    Bryan E Pfingst
    Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, Ann Arbor 48109 0506, USA
    J Acoust Soc Am 121:2236-46. 2007
    ..Twelve human subjects with cochlear implants were tested. Phase duration of symmetric biphasic pulses was modulated sinusoidally at 40 Hz...
  42. ncbi Music to electric ears: pitch and timbre perception by cochlear implant patients
    Daniel Pressnitzer
    Equipe Audition, LPE CNRS UMR 8581, Departement d Etudes Cognitives, ENS, 29 rue d Ulm, 75230 Paris Cedex 05, France
    Ann N Y Acad Sci 1060:343-5. 2005
    The sounds of music play with many perceptual dimensions. We devised a set of psychophysical procedures to better understand how recipients of cochlear implants perceive basic sound attributes involved in music listening.
  43. pmc Spoken language development in children following cochlear implantation
    John K Niparko
    Department of Otolaryngology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    JAMA 303:1498-506. 2010
    ..Cochlear implantation is a surgical alternative to traditional amplification (hearing aids) that can facilitate spoken language development in young children with severe to profound sensorineural hearing loss (SNHL)...
  44. ncbi Subjective and objective results after bilateral cochlear implantation in adults
    Roman D Laske
    Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Zurich, Switzerland
    Otol Neurotol 30:313-8. 2009
    ..To assess and compare subjective and objective results after bilateral cochlear implantation with a special emphasis on time interval between the first and second implant...
  45. ncbi Head shadow, squelch, and summation effects in bilateral users of the MED-EL COMBI 40/40+ cochlear implant
    P Schleich
    Research and Development, Medical Electronics, Innsbruck, Austria
    Ear Hear 25:197-204. 2004
    The aim of the study was to investigate the impact of bilateral cochlear implant use on speech perception in noise in bilateral users of the MED-EL COMBI 40/40+ cochlear implants.
  46. ncbi [Analysis of the cochlear implant as a treatment technique for profound hearing loss in pre and postlocutive patients]
    M Manrique
    Estudio Multicéntrico realizado por los Grupos de Implantación Coclear de la Clínica Universitaria de Navarra, Pamplona
    Acta Otorrinolaringol Esp 57:2-23. 2006
    ..4. Assess direct and indirect costs generated during the phases of a cochlear implantation programme. 5. Determine which factors have a high impact on the clinical evolution and the financial cost...
  47. ncbi Speech Recognition in noise in children with cochlear implants while listening in bilateral, bimodal, and FM-system arrangements
    Erin C Schafer
    University of Texas, Dallas, USA
    Am J Audiol 15:114-26. 2006
    Speech recognition performance in noise was examined in children with cochlear implants (CIs) when using (a) a second CI (bilateral group), (b) a hearing aid (HA) on the nonimplant ear (bimodal group), and (c) a frequency modulation (FM) ..
  48. ncbi Importance of age and postimplantation experience on speech perception measures in children with sequential bilateral cochlear implants
    B Robert Peters
    Dallas Otolaryngology Cochlear Implant Program, Dallas, TX 75230, USA
    Otol Neurotol 28:649-57. 2007
    Clinical trials in which children received bilateral cochlear implants in sequential operations were conducted to analyze the extent to which bilateral implantation offers benefits on a number of measures...
  49. ncbi Pseudospontaneous activity: stochastic independence of auditory nerve fibers with electrical stimulation
    J T Rubinstein
    Department of Otolaryngology, University of Iowa, Iowa City 52242, USA
    Hear Res 127:108-18. 1999
    We describe a novel signal processing strategy for cochlear implants designed to emphasize stochastic independence across the excited neural population...
  50. ncbi The economics of cochlear implant management in France: a multicentre analysis
    Laurent Molinier
    Department of Medical Information, INSERM U558, University Hospital Hôtel Dieu Saint Jacques, 2 Rue Viguerie, TSA 80035, 31059, Toulouse Cedex 9, France
    Eur J Health Econ 10:347-55. 2009
    ..Differences in our results compared to other studies can be explained mostly by methodological differences in cost analyses...
  51. pmc Bilateral cochlear implants in children: localization acuity measured with minimum audible angle
    Ruth Y Litovsky
    Waisman Center, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
    Ear Hear 27:43-59. 2006
    To evaluate sound localization acuity in a group of children who received bilateral (BI) cochlear implants in sequential procedures and to determine the extent to which BI auditory experience affects sound localization acuity...
  52. ncbi Cochlear implants and tinnitus
    David M Baguley
    Audiology, Addenbrooke s Hospital, Cambridge, UK
    Prog Brain Res 166:347-55. 2007
    The clinical observation that multichannel intra-cochlear cochlear implants have a suppressive effect on tinnitus in profoundly deaf patients is supported by many published studies...
  53. pmc Developmental neuroplasticity after cochlear implantation
    Andrej Kral
    Institute of Audioneurotechnology and Department of Experimental Otology, ENT Clinics, Medical University Hannover, Germany
    Trends Neurosci 35:111-22. 2012
    ..b>Cochlear implants bypass cochlear damage by directly stimulating the auditory nerve and brain, making it possible to avoid ..
  54. ncbi Speech recognition in noise as a function of the number of spectral channels: comparison of acoustic hearing and cochlear implants
    L M Friesen
    Department of Auditory Implants and Perception, House Ear Institute, Los Angeles, California 90057, USA
    J Acoust Soc Am 110:1150-63. 2001
    ....
  55. pmc Evidence that cochlear-implanted deaf patients are better multisensory integrators
    J Rouger
    Centre de Recherche Cerveau et Cognition, Université Toulouse 3, Centre National de la Recherche Scientifique, Faculte de Medecine de Rangueil, 31062 Toulouse Cedex 9, France
    Proc Natl Acad Sci U S A 104:7295-300. 2007
    ..Furthermore, they provide crucial indications to guide the rehabilitation of CI patients by using visually oriented therapeutic strategies...
  56. ncbi Communication development in children who receive the cochlear implant younger than 12 months: risks versus benefits
    Shani J Dettman
    The University of Melbourne, Parkville, Australia
    Ear Hear 28:11S-18S. 2007
    ..in device technology, two decades of pediatric clinical experience, a growing recognition of the efficacy of cochlear implants for young children, and the recent change in the U.S...
  57. pmc Correct tonotopic representation is necessary for complex pitch perception
    Andrew J Oxenham
    Speech and Hearing Bioscience and Technology Program, Harvard MIT Division of Health Sciences and Technology, and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 101:1421-5. 2004
    ..The experiments demonstrate that tonotopic representation is crucial to complex pitch perception and provide a new tool in the search for the neural basis of pitch...
  58. ncbi Preservation of hearing in cochlear implant surgery: advantages of combined electrical and acoustical speech processing
    Bruce J Gantz
    Department of Otolaryngology Head and Neck Surgery, University of Iowa Roy J and Lucille A Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA
    Laryngoscope 115:796-802. 2005
    ..Surgical strategies used for hearing preservation with a short hybrid cochlear implant are outlined. The benefits of preserved residual low-frequency hearing, improved word understanding in noise, and music appreciation are described...
  59. ncbi Normative findings of electrically evoked compound action potential measurements using the neural response telemetry of the Nucleus CI24M cochlear implant system
    D Cafarelli Dees
    Cochlear Europe Ltd, London, UK
    Audiol Neurootol 10:105-16. 2005
    ..Correlation between these two factors and the same factors describing the T- and C-levels appeared to be moderate, in the range of 0.5-0.6...
  60. pmc Cortical reorganization in children with cochlear implants
    Phillip M Gilley
    Department of Speech, Language, and Hearing Science, University of Colorado at Boulder, 2501 Kittredge Loop Rd, 409 UCB, Boulder, CO 80309 0409, USA
    Brain Res 1239:56-65. 2008
    ..cortical auditory evoked potentials in normal hearing children and in congenitally deaf children fitted with cochlear implants. High-density EEG and source modeling revealed principal activity from auditory cortex in normal hearing and ..
  61. pmc Cochlear implant use following neonatal deafness influences the cochleotopic organization of the primary auditory cortex in cats
    James B Fallon
    The Bionic Ear Institute, Melbourne, Victoria, Australia 3002
    J Comp Neurol 512:101-14. 2009
    ....
  62. pmc Over-expression of BDNF by adenovirus with concurrent electrical stimulation improves cochlear implant thresholds and survival of auditory neurons
    JENNIFER A CHIKAR
    Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan Medical School, Ann Arbor, MI 48109 5616, United States
    Hear Res 245:24-34. 2008
    ..These results indicate that the changes in the anatomy of the auditory nerve induced by the combination of Ad.BDNF inoculation and the electrical stimulation used for testing improved functional measures of CI performance...
  63. ncbi Intracochlear and extracochlear ECAPs suggest antidromic action potentials
    Charles A Miller
    Department of Otolaryngology, Head and Neck Surgery, University of Iowa Hospitals and Clinics, 21201 PFP, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Hear Res 198:75-86. 2004
    ..Compared with the feline ECAPs, the human potentials had smaller amplitudes and longer latencies. It is not clear what underlies these differences, although several factors are considered...
  64. ncbi Analysis of speech-based Speech Transmission Index methods with implications for nonlinear operations
    Ray L Goldsworthy
    Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Acoust Soc Am 116:3679-89. 2004
    ..The discussion considers the relevance of this work to predicting the intelligibility of cochlear-implant processed speech...
  65. ncbi Perceptual benefit and functional outcomes for children using sequential bilateral cochlear implants
    Karyn Louise Galvin
    Department of Otolaryngology, The University of Melbourne, East Melbourne, Vic, Australia
    Ear Hear 28:470-82. 2007
    To evaluate the additional perceptual benefit provided to children through the use of two cochlear implants in comparison to one after 6 to 13 mo experience with sequential bilateral implants.
  66. ncbi Cochlear implant optimized noise reduction
    Stefan J Mauger
    Cochlear Limited, Level 1, 174 Victoria Parade, East Melbourne 3002, Victoria, Australia
    J Neural Eng 9:065007. 2012
    ..Recent psychoacoustic studies have suggested changes to noise-reduction techniques specifically for cochlear implants, due to differences between hearing aid recipient and cochlear implant recipient hearing...
  67. ncbi Spoken language scores of children using cochlear implants compared to hearing age-mates at school entry
    Ann E Geers
    University of Texas Southwestern Medical Center, Dallas, USA
    J Deaf Stud Deaf Educ 14:371-85. 2009
    ..three questions: Is it realistic to expect age-appropriate spoken language skills in children with cochlear implants (CIs) who received auditory-oral intervention during the preschool years? What characteristics predict ..
  68. ncbi Speech understanding in background noise with the two-microphone adaptive beamformer BEAM in the Nucleus Freedom Cochlear Implant System
    Ann Spriet
    ExpORL, Dept Neurosciences, KU Leuven, Leuven, Belgium
    Ear Hear 28:62-72. 2007
    ..This paper evaluates the benefit of the two-microphone adaptive beamformer BEAM in the Nucleus Freedom cochlear implant (CI) system for speech understanding in background noise by CI users...
  69. ncbi Speech perception with mono- and quadrupolar electrode configurations: a crossover study
    Lucas H M Mens
    KNO Audiology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Otol Neurotol 26:957-64. 2005
    ..To study the effect of two multipolar electrode configurations on speech perception, pitch perception, and the intracochlear electrical field...
  70. ncbi Histopathology of human cochlear implants: correlation of psychophysical and anatomical measures
    Aayesha M Khan
    Cochlear Implant Research Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA
    Hear Res 205:83-93. 2005
    ..These results lead us to hypothesize that 3D techniques will be required to asses the impact of peripheral anatomy on the benefit patients derive from cochlear implantation...
  71. ncbi Hearing conservation surgery using the Hybrid-L electrode. Results from the first clinical trial at the Medical University of Hannover
    Thomas Lenarz
    Department of Otolaryngology, Medical University of Hannover, Hannover, Germany
    Audiol Neurootol 14:22-31. 2009
    ..The use of the residual acoustic hearing offers specific advantages, especially for understanding speech in noise and for spatial hearing...
  72. ncbi Factors affecting auditory performance of postlinguistically deaf adults using cochlear implants: an update with 2251 patients
    Peter Blamey
    Bionics Institute, Melbourne, Vic, Australia
    Audiol Neurootol 18:36-47. 2013
    ....
  73. ncbi How internet telephony could improve communication for hearing-impaired individuals
    Georgios Mantokoudis
    University Department of Otorhinolaryngology, Head and Neck Surgery, Inselspital, Bern, Switzerland
    Otol Neurotol 31:1014-21. 2010
    ..To test, whether modern Internet telephony with a broadband transmission (0.1-8 kHz) of speech improves speech perception in comparison to conventional telephony (0.3-3.5 kHz) in hearing-impaired and normal-hearing adults...
  74. ncbi The effectiveness of bilateral cochlear implants for severe-to-profound deafness in children: a systematic review
    Marloes Sparreboom
    Department of Otorhinolaryngology, Head and Neck Surgery, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands
    Otol Neurotol 31:1062-71. 2010
    ..Recently, the National Institute for Health and Clinical Excellence (NICE) in the U.K. has conducted a systematic review on cochlear implantation. We decided to update the pediatric part of the NICE review...
  75. ncbi Understanding speech in modulated interference: cochlear implant users and normal-hearing listeners
    Peggy B Nelson
    Department of Communication Disorders, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Acoust Soc Am 113:961-8. 2003
    ..The lack of release from masking occurs in implant listeners independent of their device characteristics, and may be attributable to the nature of implant processing strategies and/or the lack of spectral detail in processed stimuli...
  76. ncbi Genetic characteristics in children with cochlear implants and the corresponding auditory performance
    Chen Chi Wu
    Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan
    Laryngoscope 121:1287-93. 2011
    To explore the genetic characteristics of children with cochlear implants (CIs) and to correlate the auditory performance after implantation to the genetic diagnosis of children with CIs.
  77. ncbi Evaluation of speech recognition in noise with cochlear implants and dynamic FM
    Jace Wolfe
    Hearts for Hearing Foundation, USA
    J Am Acad Audiol 20:409-21. 2009
    ..of personal frequency-modulated (FM) systems significantly improves speech recognition in noise for users of cochlear implants (CIs)...
  78. ncbi Cortical representation of interaural time difference in congenital deafness
    J Tillein
    Laboratory of Auditory Neuroscience, Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg Eppendorf, D 20246 Hamburg, Germany
    Cereb Cortex 20:492-506. 2010
    ..Hearing and congenitally deaf cats were stimulated through binaural cochlear implants and unit responses were collected in the subregion of field A1 showing the largest amplitudes of evoked ..
  79. pmc Temporal modulation transfer functions in cochlear implantees using a method that limits overall loudness cues
    Matthew Fraser
    School of Psychological Sciences, The University of Manchester, Manchester M13 9PL, UK
    Hear Res 283:59-69. 2012
    Temporal modulation transfer functions (TMTFs) were measured for six users of cochlear implants, using different carrier rates and levels...
  80. ncbi A practical method of predicting the loudness of complex electrical stimuli
    Colette M McKay
    Department of Otolaryngology, The University of Melbourne, 384 388 Albert Street, East Melbourne 3002, Australia
    J Acoust Soc Am 113:2054-63. 2003
    The output of speech processors for multiple-electrode cochlear implants consists of current waveforms with complex temporal and spatial patterns. The majority of existing processors output sequential biphasic current pulses...
  81. pmc Phonological awareness, reading skills, and vocabulary knowledge in children who use cochlear implants
    Caitlin M Dillon
    J Deaf Stud Deaf Educ 17:205-26. 2012
    ..This finding suggests that lexicon size is a mediating factor in the relationship between the children's phonological awareness and reading skills, a finding that has also been reported for typically developing hearing children...
  82. ncbi Psychometric functions and temporal integration in electric hearing
    G S Donaldson
    Department of Otolaryngology, University of Minnesota, Minneapolis 55455, USA
    J Acoust Soc Am 101:3706-21. 1997
    ....
  83. ncbi A safety evaluation of dexamethasone-releasing cochlear implants: comparative study on the risk of otogenic meningitis after implantation
    Katharina Niedermeier
    Clinic for Otorhinolaryngology, Head and Neck Surgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
    Acta Otolaryngol 132:1252-60. 2012
    ..Dexamethasone released from a cochlear implant seems not to enhance the risk for postoperative infections...
  84. pmc Temporal response properties of the auditory nerve: data from human cochlear-implant recipients
    Michelle L Hughes
    Boys Town National Research Hospital, Lied Learning and Technology Center, 425 North 30th Street, Omaha, NE 68131, USA
    Hear Res 285:46-57. 2012
    ..Differences in temporal response properties across the cochlea within subjects may have implications for developing new speech-processing strategies that employ varied rates across the array...
  85. ncbi Combining acoustic and electrical speech processing: Iowa/Nucleus hybrid implant
    Bruce J Gantz
    Department of Otolaryngology Head and Neck Surgery, University of Iowa, Iowa City, IA 52242 1078, USA
    Acta Otolaryngol 124:344-7. 2004
    ..In addition, we test whether residual hearing can be preserved when an electrode is placed up to 10 mm into the inner ear, and whether the site of electrical stimulation influences speech perception...
  86. ncbi Predicting cochlear implant outcome from brain organisation in the deaf
    Anne Lise Giraud
    INSERM U742, UPMC Paris 6 and Département d études cognitives, Ecole Normale Superieure, Paris, France
    Restor Neurol Neurosci 25:381-90. 2007
    Cochlear implantation is an effective technique for restoring hearing in the profoundly deaf. Although cochlear implants are a therapeutical success, huge performance variability in speech comprehension is observed after implantation...
  87. ncbi Uncovering auditory evoked potentials from cochlear implant users with independent component analysis
    Filipa C Viola
    Neuropsychology Lab, Department of Psychology, University of Oldenburg, Germany
    Psychophysiology 48:1470-80. 2011
    ..95) that were previously contaminated with CI artifacts. The results confirm that after ICA, good quality AEPs can be recovered, facilitating the objective, noninvasive study of auditory cortex function in CI users...
  88. pmc Multivariate predictors of music perception and appraisal by adult cochlear implant users
    Kate Gfeller
    School of Music, University of Iowa, USA
    J Am Acad Audiol 19:120-34. 2008
    ..Music listening background, residual hearing (i.e., hearing aid use), cognitive factors, and some demographic factors predicted several indices of perceptual accuracy or appraisal of music...
  89. pmc Music perception by cochlear implant and normal hearing listeners as measured by the Montreal Battery for Evaluation of Amusia
    William B Cooper
    Callier Advanced Hearing Research Center, The University at Dallas, Dallas, TX, USA
    Ear Hear 29:618-26. 2008
    ..Ann N Y Acad Sci, 999, 58-75) to assess the music perception abilities of cochlear implant (CI) users...
  90. ncbi Speech processing in vocoder-centric cochlear implants
    Philipos C Loizou
    Department of Electrical Engineering, Jonsson School of Engineering and Computer Science, University of Texas at Dallas, Richardson 75083 0688, USA
    Adv Otorhinolaryngol 64:109-43. 2006
    ..An overview of the various vocoder-centric processing strategies proposed for cochlear implants since the late 1990s is provided including the strategies used in different commercially available implant ..
  91. pmc Psychoacoustic abilities associated with music perception in cochlear implant users
    Jong Ho Won
    Department of Otolaryngology Head and Neck Surgery, Virginia Merrill Bloedel Hearing Research Center, University of Washington, Seattle, Washington 98195, USA
    Ear Hear 31:796-805. 2010
    ..It was hypothesized that the variability in the performance of music and speech perception may be related to differences in the sensitivity to specific acoustic features such as spectral changes or temporal modulations, or both...
  92. ncbi Localization cues with bilateral cochlear implants
    Bernhard U Seeber
    Institute for Human Machine Communication, Technische Universität München Arcisstr 21, 80333 München, Germany
    J Acoust Soc Am 123:1030-42. 2008
    Selected subjects with bilateral cochlear implants (CIs) showed excellent horizontal localization of wide-band sounds in previous studies...
  93. ncbi Bilateral cochlear implants should be the standard for children with bilateral sensorineural deafness
    Blake C Papsin
    Department of Otolaryngology, Faculty of Medicine, University of Toronto, Canada
    Curr Opin Otolaryngol Head Neck Surg 16:69-74. 2008
    Bilateral cochlear implants are provided to children in an attempt to establish binaural processing and allow hearing with greater ease...
  94. ncbi Improving melody recognition in cochlear implant recipients through individualized frequency map fitting
    Walter Di Nardo
    Institute of Otorhinolaryngology, Catholic University of the Sacred Heart, A Gemelli University Hospital, Largo Gemelli, 8, 00168, Rome, Italy
    Eur Arch Otorhinolaryngol 268:27-39. 2011
    ....
  95. ncbi Evolution of non-speech sound memory in postlingual deafness: implications for cochlear implant rehabilitation
    D S Lazard
    Ecole Normale Superieure, INSERM U960, Paris F 75005, France
    Neuropsychologia 49:2475-82. 2011
    ..These results complement those of other studies on speech processing, suggesting that both speech and NSS representations need to be maintained during deafness to ensure the success of CI...
  96. ncbi Auditory midbrain implant: histomorphologic effects of long-term implantation and electric stimulation of a new deep brain stimulation array
    Minoo Lenarz
    Department of Otolaryngology, Hannover Medical University, Hannover, Germany
    Otol Neurotol 28:1045-52. 2007
    ..Chronic implantation and electric stimulation with a human prototype auditory midbrain implant (AMI) array within the inferior colliculus achieves minimal neuronal damage and does not cause any severe complications...
  97. ncbi Effects of introducing unprocessed low-frequency information on the reception of envelope-vocoder processed speech
    Michael K Qin
    Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Acoust Soc Am 119:2417-26. 2006
    ..The findings provide further support for efforts to make use of residual acoustic hearing in cochlear-implant users...
  98. ncbi Development of a specially tailored local drug delivery system for the prevention of fibrosis after insertion of cochlear implants into the inner ear
    Anne Bohl
    Institute for Biomedical Engineering, University of Rostock, Friedrich Barnewitz Str 4, 18119, Rostock, Germany
    J Mater Sci Mater Med 23:2151-62. 2012
    ..The performed in vitro biocompatibility study confirmed that the released DMS was non-toxic for cultured spiral ganglion cells...
  99. pmc Detection and rate discrimination of amplitude modulation in electrical hearing
    Monita Chatterjee
    Cochlear Implants and Psychophysics Laboratory, Department of Hearing and Speech Sciences, University of Maryland, College Park, Maryland 20742, USA
    J Acoust Soc Am 130:1567-80. 2011
    ..Overall, results indicated that intensity cues did not play an important role in temporal envelope processing by the average CI listener...
  100. pmc Recognition of interrupted sentences under conditions of spectral degradation
    Monita Chatterjee
    Cochlear Implants and Psychophysics Laboratory, Department of Hearing and Speech Sciences, The University of Maryland, College Park, Maryland 20742, USA
    J Acoust Soc Am 127:EL37-41. 2010
    ..A hypothesis that the natural voice-pitch variations in speech would help in the perceptual reconstruction of the sentences was not supported by experimental results...
  101. pmc Amplitude modulation and loudness in cochlear implantees
    Colette M McKay
    Department of Otolaryngology, The University of Melbourne, Melbourne, 3054, Australia
    J Assoc Res Otolaryngol 11:101-11. 2010
    ..We show that several previously published results regarding the effect of carrier rate and added noise on modulation detection could be reinterpreted in the light of these findings...

Research Grants73

  1. Visual Speech Perception and Neural Processing
    LYNNE ESTHER BERNSTEIN; Fiscal Year: 2010
    ..individuals with hearing loss may need to rely on lipreading, even if they have sensory aids (hearing aids, cochlear implants)...
  2. DEAFNESS AND OSSIFICATION IN LABYRINTHITIS OSSIFICANS
    Hilary Brodie; Fiscal Year: 2004
    ..b>Cochlear implants are a significant treatment option for improving hearing and quality of life in these patients...
  3. Marking hair cell progenitors with BAC transgenics
    Neil Segil; Fiscal Year: 2004
    ..only treatment for deafness due to sensory hair cell loss is the use of prosthetics such as hearing aids and cochlear implants. Strategies for hair cell repair that involve either stimulation of quiescent cells in the mature organ of ..
  4. FUNCTIONAL EFFECTS OF DEAFNESS AND NEURAL STIMULATION
    BRYAN PFINGST; Fiscal Year: 2005
    ..with the large differences across subjects in psychophysical and speech recognition performance with cochlear implants. In the set of experiments proposed in this application, we will use neurophysiological measures to ..
  5. AUDITORY ANALYSIS IN ELECTRIC HEARING
    David Nelson; Fiscal Year: 2009
    ..Work in the current proposal focuses on the spatial resolution needed to resolve spectral acoustic cues. Cochlear implants encode stimulus frequency by electrode position along the cochlear duct, with the assumption that different ..
  6. Genetic Studies of Optic Atrophy
    Taosheng Huang; Fiscal Year: 2012
    ..The hearing loss is associated with asynchronous cochlear conduction and cochlear implants provide remarkable results to restore hearing...
  7. Auditory Neuroprotection by Small Molecule Agonists of the TrkB Receptor
    Keqiang Ye; Fiscal Year: 2013
    ..Since the survival of SG neurons is the basis for cochlear implants to work, these encouraging results have stimulated enormous interest in translation-oriented research aiming ..
  8. Bilateral cochlear implants: Physiology and psychophysics
    Bertrand Delgutte; Fiscal Year: 2012
    ..and neural computation in order to gain a basic understanding of the ITD processing with bilateral cochlear implants. Psychophysical experiments in bilaterally-implanted human subjects will be conducted in parallel with ..
  9. Stimuli promoting the survival of spiral ganglion neurons
    Steven H Green; Fiscal Year: 2011
    ..SGN degeneration reduces the efficacy of cochlear implants, currently the only treatment for sensorineural deafness...
  10. Insm1 in Development of Spiral and Vestibular Ganglia
    Sarah M Lorenzen; Fiscal Year: 2013
    ..provided by applicant): Currently, within the United States, 42,600 adults and 28,400 children have cochlear implants, which depend on the spiral ganglion neurons (SGNs) for conducting auditory information including human ..
  11. Advanced technology for neural interfaces based on microstimulation
    DOUGLAS BUCHANAN MCCREERY; Fiscal Year: 2013
    ..auditory prostheses towards providing speech recognition that is at least equivalent to that of users of cochlear implants. Persons who lack a functional auditory nerve cannot benefit form cochlea implants, but some hearing can be ..
  12. Deciphering the Usher I protein interactome using a genetic approach
    Qing Y Zheng; Fiscal Year: 2013
    ..Many USH patients will benefit from cochlear implants, but preservation of spiral ganglion cells is important for success of cochlear implants because a minimal ..
  13. Neural substrates for matching hearing to utterance
    Darcy B Kelley; Fiscal Year: 2012
    ..When prelingually deaf adults receive cochlear implants, the quality of the speech production improves along with speech perception [65]...
  14. Effectiveness of Therapy via Telemedicine following Cochlear Implants
    Anu Sharma; Fiscal Year: 2013
    ....
  15. Sound Source Segregation
    Mark A Bee; Fiscal Year: 2013
    ..Hearing aids and cochlear implants often provide their users little benefit when it comes to segregating multiple sound sources...
  16. Synaptic basis of perceptual learning in primary auditory cortex
    ROBERT CROOKS FROEMKE; Fiscal Year: 2013
    ..especially for learning the significance of sensory signals such as speech, for the use of devices such as cochlear implants, and for recovery after short-term deafness...
  17. Cocktail Party Problem: Perspective on Neurobiology of Auditory Scene Analysis
    Mounya Elhilali; Fiscal Year: 2013
    ..medical, industrial, military and robotics domains;as well as improving communication aids (hearing aids, cochlear implants, speech-based human-computer interfaces) for the sensory-impaired and aging brains...
  18. Motley Diversity Supplement
    Edwin W Rubel; Fiscal Year: 2013
    ..a new level of clinical importance through universal newborn screening and enormously increased use of cochlear implants in congenitally and prelingually hearing impaired infants...
  19. Cross-modal re-organization in children with cochlear implants
    Julia Dee Campbell; Fiscal Year: 2013
    ..cortex) have been found via high-density electroencephalography (EEG) recordings in adults who received cochlear implants;positron emission tomography (PET) imaging has shown similar findings in congenitally deaf children who ..
  20. Effects of Sensorineural Hearing Loss on Robust Speech Coding
    Michael G Heinz; Fiscal Year: 2013
    ..and impaired hearing, and may have important implications for improving the ability of hearing aids and cochlear implants to restore speech perception in noise...
  21. Cholinergic inputs to excitatory and inhibitory midbrain auditory circuits
    JEFFREY GARRETT MELLOTT; Fiscal Year: 2013
    ..such as presbycusis or tinnitus) associated with aging or injury and for the evolving design and use of cochlear implants and brainstem implants...
  22. Activation of inner ear stem cells by B-catenin
    Fuxin Shi; Fiscal Year: 2012
    ..goal of this project is to find a noninvasive approach that could become a therapy for the treatment of sensorineural hearing loss for which there is currently no effective intervention other than hearing aids or cochlear implants.
  23. Anatomical analysis of cortical projections to the auditory midbrain
    KYLE TOKUICHI NAKAMOTO; Fiscal Year: 2012
    ..such as presbycusis or tinnitus) associated with aging or injury and for the evolving design and use of cochlear implants and brainstem implants...
  24. Functional anatomy of the auditory system
    Brett R Schofield; Fiscal Year: 2013
    ..Understanding and improving these functions is an important goal in persons with hearing loss, cochlear implants or various disorders such as autism or schizophrenia...
  25. Sustained Release Inner Ear Delivery of Corticosteroid
    William H Slattery; Fiscal Year: 2011
    ..We furthermore formulated prototype cochlear implants releasing fluticasone, and have laid the basis for further commercialization with a corporate partner: ..
  26. Complex Pitch Perception in Complex Environments
    Andrew J Oxenham; Fiscal Year: 2013
    ..provided by applicant): Two of the most common complaints of individuals with hearing impairment or cochlear implants are that they are unable to "hear out" voices in the background of other sounds, and are unable to enjoy ..
  27. Cochlear Implants in Reinnervated Ears
    Yehoash Raphael; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Perception of sound with cochlear implants (CIs) is currently accomplished, in most cases, by stimulating spiral ganglion neuron (SGN) bodies in Rosenthal's canal, since cochleae without hair ..
  28. Outcomes in Children with Developmental Delay and Deafness: a Randomized Trial
    John S Oghalai; Fiscal Year: 2013
    ..low frequency sounds in a similar fashion to what was done for all deaf children prior to the development of cochlear implants. The typical clinical outcome is sound awareness, i.e. the ability to detect environmental sounds and voices...
  29. HEALTH BEHAVIOR RESEARCH IN MINORITY PEDIATRIC POPULATIONS
    Alan M Delamater; Fiscal Year: 2012
    ..for brain cancer (American Cancer Society);prenatal drug exposure and child development (NIDA);children with cochlear implants (NIH);and studies of the health behavior effects of violence exposure...
  30. Cortical Responses to Cochlear Implant Stimulation
    LUKE AARON JOHNSON; Fiscal Year: 2012
    The long-term goal of this project is to understand the neural mechanisms underlying restored hearing by cochlear implants (CI). We propose a new non-human primate model for CI research, the common marmoset (Callithrix jacchus)...
  31. SINGLE-CELL MARKING STUDIES OF THE AUDITORY NERVE
    David K Ryugo; Fiscal Year: 2010
    ..structure in auditory nerve terminals, and that synaptic rescue occurs after providing young cats with cochlear implants (Ryugo et al. 2005)...
  32. Genotype-Phenotype Relationships in Auditory Neuropathy
    Christina L Runge; Fiscal Year: 2011
    ..highly heterogeneous, including the responses to different intervention approaches such as hearing aids and cochlear implants. There are several possible causes for AN/AD, which if known may lead to early and appropriate intervention ..
  33. Localization and Speech Intelligibility in EAS and Bilateral CI Users
    Louise H Loiselle; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Until relatively recently, most cochlear implants were unilateral. Now, however, there are two groups of implant patients who can use the same kind of input from two ears...
  34. RESEARCH TRAINING IN SPEECH AND HEARING SCIENCES
    Lynne A Werner; Fiscal Year: 2013
    ..include auditory development, auditory perception and learning, auditory physiology, animal communication, cochlear implants, genetics, language development, language science and disorders, signal processing, speech motor control, ..
  35. Research Training for Clinical Audiologists
    WILLIAM WALTER CLARK; Fiscal Year: 2012
    ..and treatment of age-related and noise-induced hearing loss, sensory cell regeneration and development, cochlear implants in children and adults, language acquisition and speech perception in children with hearing impairment, ..
  36. Developing Research Careers in the Hearing Sciences
    Linda J Hood; Fiscal Year: 2013
    ..motion perception, directional hearing and amplification, pediatric audiology, speech recognition in noise, cochlear implants, vestibular function, auditory neural and multisensory cortical function in humans and animal models, and ..
  37. Binaural Sensitivity and Spatial Hearing in Bilateral Cochlear Implant Users
    Ruth Y Litovsky; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The number of people who are deaf and who receive bilateral cochlear implants (CIs) has grown substantially in recent years...
  38. Contributions of peripheral spatial resolution to speech perception in CI users
    Rachel A Scheperle; Fiscal Year: 2013
    ..b>Cochlear implants (CIs) attempt to mimic this spatial separation of frequency by allocating certain spectral components within ..
  39. Coding of Auditory Space in the Avian Brain
    JOSE L PENA; Fiscal Year: 2013
    ..b>Cochlear implants that provide encoding of stimuli in ways that are more biologically relevant can be built, while devices ..
  40. Auditory Thalamic Implant
    STEVEN WAN CHEUNG; Fiscal Year: 2012
    ..Extracranial cochlear implants are inappropriate for NF2 patients without intact auditory nerves, a consequence of bilateral vestibular ..
  41. TRAINING IN SPEECH, HEARING, AND SENSORY COMMUNICATION
    David B Pisoni; Fiscal Year: 2013
    ..phonologicalacquisitionand development;clinical audiology,speech- language pathology, hearing impairment and cochlear implants;spoken word recognition and lexical access;and neuroimaging and computationalmodelingofspoken language ..
  42. OBJECTIVE MEASURES IN AUDITORY IMPLANTS 6TH INTERNATIONAL SYMPOSIUM
    Jill B Firszt; Fiscal Year: 2010
    ..The conference will bring together researchers and clinicians in the field of cochlear implants and neighboring disciplines who employ a range of objective measures, including both electrophysiology and ..
  43. Somatosensory-to-auditory cross-modal plasticity in cochlear implanted children
    GARRETT JOSEPH CARDON; Fiscal Year: 2013
    ..b>Cochlear implants (CI) are devices that provide access to sound for the auditory system by electrically stimulating the VIII ..
  44. Neural Correlates of Streaming of Complex Sounds
    Shihab A Shamma; Fiscal Year: 2013
    ..one of the most common complaints of hearing-impaired individuals (including wearers of hearing aids or cochlear implants) is that they find it difficult to separate concurrent streams of sounds, and to attend selectively to one ..
  45. Behavioral and physiological changes in acoustic-electrical pitch matching
    Chin Tuan Tan; Fiscal Year: 2013
    ..the information gained from these proposed projects has the potential to directly shape future fitting of cochlear implants, and may have an effect on patient care...
  46. Conference Grant for symposium entitled "Emerging Issues in Cochlear Implanta
    DONNA L SORKIN; Fiscal Year: 2013
    ..issues: Hearing Preservation, Implantation of the Very Young, Implanting Multiply Involved Children, Cochlear Implants in Single-Sided Deafness, Cochlear Implantation in Older Adults, and Telehealth and Cochlear Implantation...
  47. Cochlear Implants: Combined Electric and Binaural Acoustic Stimulation
    RENE H GIFFORD; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): In one of the newest applications of cochlear implants, individuals with bilateral low-frequency hearing receive a short electrode array in one cochlea with the aim of preserving hearing in that ear...
  48. Development of Translational Research to Improve Outcomes for Cochlear Implants
    Paul W Flint; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Although cochlear implants (CI) can dramatically improve speech recognition for many patients in quiet surroundings, CI performance and outcome is variable across individuals;speech recognition in ..
  49. Iowa Cochlear Implant Clinical Research Center Project VI
    Bruce Jay Gantz; Fiscal Year: 2013
    ..Our second objective is to define the boundaries between the appropriateness of hearing aids versus cochlear implants in populations of hard of hearing children...
  50. Auditory Cortical Processing of Communication Sounds
    KAMAL K SEN; Fiscal Year: 2010
    ..g., in children with cochlear implants. Our long-term goal is to understand the neural basis for cortical processing of complex sounds and ..
  51. Structure and function of the medial superior olive
    Philip H Smith; Fiscal Year: 2013
    ..stages of knowing how to optimally present such stimuli to the hard of hearing or deaf via hearing aids or cochlear implants. One of the major impediments on this path is that we still do not have a complete understanding the basic ..
  52. Perceptual implications of cochlear implant electrode-neuron interfaces
    Julie A Bierer; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cochlear implants are highly successful neural prostheses that enhance or restore hearing to the severely hearing impaired...
  53. Auditory coding at the hair cell ribbon synapse
    Geng Lin Li; Fiscal Year: 2010
    ..RELEVANCE: In the United States, roughly 23,000 adults and 15,500 children have received cochlear implants, which restore part of their hearing by directly stimulating auditory nerve fibers with electrodes...
  54. Cross-modal changes in auditory cortex circuitry after visual deprivation
    EMILY ROSE PETRUS; Fiscal Year: 2013
    ..For example, the success of cochlear implants for early deaf people is quite low because extensive cortical reorganization no longer can effectively ..
  55. Cellular basis of sound localization
    CATHERINE EMILY CARR; Fiscal Year: 2013
    ..noise;these different strategies can provide inspiration for the development of new technologies such as cochlear implants. We propose a set of experiments to establish the nature of the interaural time difference (ITD) map, its ..
  56. Deaf infants'cognitive skills and their post-cochlear implant language outcomes
    CARISSA LYNN SHAFTO; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: This research addresses the issue of why some deaf children with cochlear implants learn spoken language very well while others have poor language outcomes and, consequently, struggle with ..
  57. Neurocognitive Processes in Deaf Children with Cochlear Implants
    David B Pisoni; Fiscal Year: 2013
    ..Past research on cochlear implants has been narrowly focused on speech and language outcomes and efficacy of cochlear implantation as a medical ..
  58. Miniaturized Laser Sources for Optical Neuroprostheses
    MATTHEW DUMMER; Fiscal Year: 2012
    ..For instance, cochlear implants have been very successful in restoring hearing, but still face limitations in terms of their performance in ..
  59. Experimental - Theoretical Studies of Cochlear Mechanisms
    Dennis M Freeman; Fiscal Year: 2013
    ..practical applications for the delineation of inner-ear disorders (and concomitant suggestions for treatment) and for the design of speech-processing devices such as cochlear implants, hearing aids, and speech-recognition systems.
  60. Effects of language experience on early cortical and subcortical pitch encoding
    Ananthanarayan Krishnan; Fiscal Year: 2013
    ..of pitch representation in a target population;monitor changes in pitch representation under a retraining protocol and/or in the development of optimal signal processing strategies for conventional hearing aids and/or cochlear implants.
  61. Computer-based auditory skill building program for aural (re)habilitation
    PAMELA ALLISON CONNORS; Fiscal Year: 2012
    ..Of these, almost 10 million have hearing aids and 67,000 have cochlear implants. The goal of auditory (re)habilitation (AR) programs is to build the listening skills of individuals with ..
  62. DISSECTING THE EAR NEUROSENSORY DEVELOPMENT.
    Bernd Fritzsch; Fiscal Year: 2010
    ..and to guide growing afferents to reach either regenerated hair cells or stimulating electrodes of cochlear implants. We will focus in this application on three steps required to develop and connect hair cells and sensory ..
  63. Information processing at auditory nerve synapses
    Matthew A Xu Friedman; Fiscal Year: 2011
    ..This work may lead to improvements both in existing cochlear implants and in implants that stimulate the cochlear nucleus directly.
  64. Targeted Expression of Atoh1 in Cochlear Supporting Cells
    Mark A Parker; Fiscal Year: 2011
    ..of this research is to treat hearing loss with more effective therapies than provided by hearing aids or cochlear implants. Specifically, this research is designed to investigate the basic mechanisms by which the auditory sensory ..
  65. Temporal Effects in Forward Masking, Suppression, and Simultaneous Masking
    Elizabeth A Strickland; Fiscal Year: 2012
    ..This research could suggest novel processing strategies that might be used in hearing aids and cochlear implants to improve perception in background noise...
  66. Contrast Enhancement to Improve Speech Recognition with Hearing Devices
    Keith R Kluender; Fiscal Year: 2010
    ..research is to refine and implement signal processing strategies that improve performance of hearing aids and cochlear implants in order to provide better hearing and quality of life to millions of Americans with hearing impairments.
  67. MODIOLAR-HUGGING ELECTRODE SYSTEM FOR COCHLEAR IMPLANTS
    Dorcas Kessler; Fiscal Year: 1999
    b>Cochlear implants are designed to restore auditory perception to patients with severe to profound sensorineural hearing loss...
  68. Optimized Conditioned Processing for Cochlear Implants
    Jay T Rubinstein; Fiscal Year: 2010
    ..In unilateral implantees, this work has already demonstrated substantial benefit in a limited number of subjects;it is our goal to deliver these benefits to the broader population of implant recipients. ..
  69. AUDITORY NERVE RESPONSE TO SMALL ELECTRICAL PULSES
    Roger Miller; Fiscal Year: 2001
    ..of cat auditory nerve fibers, in order to improve our understanding of the neural response driven by cochlear implants. Psychophysical studies in cats have demonstrated their ability to perceive electrical stimulation of the ..
  70. Two-photon calcium imaging of the effects of cortical microstimulation
    R Reid; Fiscal Year: 2009
    ..Worldwide, more than 60,000 deaf patients have recovered hearing through cochlear implants. Similarly, deep brain stimulation has proven highly valuable in the treatment of intractable movement ..
  71. Psychophysics of speech processor modifications in cochlear implants
    Jong Ho Won; Fiscal Year: 2010
    ..The main point of the proposed study is to address the effect of sound processors on the ability of cochlear implant users to hear acoustic changes that are relevant to their clinical success. ..
  72. IMPROVED COCHLEAR IMPLANTS PSYCHOPHYSICS & ENGINEERING
    Graeme Clark; Fiscal Year: 1993
    ..Ca. The integrated circuit will be packaged into an implantable receiver- stimulator under contract to Cochlear Pty. Limited, Sydney...
  73. Probing the cochlea with partial tripolar stimulation in cochlear implantees
    Julie A Bierer; Fiscal Year: 2010
    b>Cochlear implants are highly successful neural prostheses that enhance or restore hearing to the severely hearing impaired...