bioprosthesis

Summary

Summary: Prosthesis, usually heart valve, composed of biological material and whose durability depends upon the stability of the material after pretreatment, rather than regeneration by host cell ingrowth. Durability is achieved 1, mechanically by the interposition of a cloth, usually polytetrafluoroethylene, between the host and the graft, and 2, chemically by stabilization of the tissue by intermolecular linking, usually with glutaraldehyde, after removal of antigenic components, or the use of reconstituted and restructured biopolymers.

Top Publications

  1. ncbi Comparative rest and exercise hemodynamics of 23-mm stentless versus 23-mm stented aortic bioprostheses
    R Fries
    Department of Cardiology and Angiology, University Hospitals Homburg, Homburg Saar, Germany
    Ann Thorac Surg 69:817-22. 2000
  2. ncbi A case of Carpentier-Edwards pericardial bioprosthesis in mitral position explanted 22 years after implantation
    Suguru Kubota
    Department of Cardiovascular Surgery, Hokkaido University Hospital, Kita ku, Sapporo, Japan
    J Artif Organs 13:48-50. 2010
  3. ncbi Trans-apical aortic valve implantation using a new self-expandable bioprosthesis: initial outcomes
    Jörg Kempfert
    Heartcenter University of Leipzig, Leipzig, Germany
    Eur J Cardiothorac Surg 40:1114-9. 2011
  4. ncbi Ross operation with a tissue-engineered heart valve
    Pascal M Dohmen
    Department of Cardiovascular Surgery, Charite, Humboldt University Berlin, Germany
    Ann Thorac Surg 74:1438-42. 2002
  5. ncbi Xenogeneic extracellular matrix as a scaffold for tissue reconstruction
    Stephen F Badylak
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, 100 Technology Drive, Suite 200, Pittsburgh, PA 15219, USA
    Transpl Immunol 12:367-77. 2004
  6. ncbi Evaluation of anatomic valve opening and leaflet morphology in aortic valve bioprosthesis by using multidetector CT: comparison with transthoracic echocardiography
    Fabien Chenot
    Divisions of Cardiology and Radiology Cliniques Universitaires St Luc, Universite Catholique de Louvain, Avenue Hippocrate 10 2881, B 1200 Brussels, Belgium
    Radiology 255:377-85. 2010
  7. ncbi Porous scaffold design for tissue engineering
    Scott J Hollister
    Scaffold Tissue Engineering Group, Department of Biomedical Engineering, The University of Michigan, Ann Arbor, Michigan 41809, USA
    Nat Mater 4:518-24. 2005
  8. ncbi Performance of bioprostheses and mechanical prostheses assessed by composites of valve-related complications to 15 years after mitral valve replacement
    W R E Jamieson
    University of British Columbia, Vancouver, British Columbia, Canada
    J Thorac Cardiovasc Surg 129:1301-8. 2005
  9. ncbi Cardiac valvular surgery in dialysis patients: comparison of surgical outcome for mechanical versus bioprosthetic valves
    Kentaro Umezu
    Department of Cardiovascular Surgery, The Heart Institute of Japan, Tokyo Women s Medical University, Tokyo, 162 8666, Japan
    Gen Thorac Cardiovasc Surg 57:197-202. 2009
  10. ncbi Long-term survival of dialysis patients in the United States with prosthetic heart valves: should ACC/AHA practice guidelines on valve selection be modified?
    Charles A Herzog
    Cardiovascular Special Studies Center, US Renal Data System, Department of Internal Medicine, Division of Cardiology, University of Minnesota, Minneapolis 55415, USA
    Circulation 105:1336-41. 2002

Research Grants

Detail Information

Publications256 found, 100 shown here

  1. ncbi Comparative rest and exercise hemodynamics of 23-mm stentless versus 23-mm stented aortic bioprostheses
    R Fries
    Department of Cardiology and Angiology, University Hospitals Homburg, Homburg Saar, Germany
    Ann Thorac Surg 69:817-22. 2000
    ..The hemodynamic superiority of stentless valves at rest has been generally accepted, but there is a lack of studies on exercise hemodynamics...
  2. ncbi A case of Carpentier-Edwards pericardial bioprosthesis in mitral position explanted 22 years after implantation
    Suguru Kubota
    Department of Cardiovascular Surgery, Hokkaido University Hospital, Kita ku, Sapporo, Japan
    J Artif Organs 13:48-50. 2010
    A case of Carpentier-Edwards PERIMOUNT (CEP) mitral pericardial bioprosthesis explanted 22 years after the valve replacement is reported. This patient underwent the previous replacement at the age of 50...
  3. ncbi Trans-apical aortic valve implantation using a new self-expandable bioprosthesis: initial outcomes
    Jörg Kempfert
    Heartcenter University of Leipzig, Leipzig, Germany
    Eur J Cardiothorac Surg 40:1114-9. 2011
    ..As an alternative device, a self-expanding sub-coronary trans-apical bioprosthesis was evaluated.
  4. ncbi Ross operation with a tissue-engineered heart valve
    Pascal M Dohmen
    Department of Cardiovascular Surgery, Charite, Humboldt University Berlin, Germany
    Ann Thorac Surg 74:1438-42. 2002
    ..In this report a viable heart valve was created from decellularized cryopreserved pulmonary allograft that was seeded with viable autologous vascular endothelial cells (AVEC)...
  5. ncbi Xenogeneic extracellular matrix as a scaffold for tissue reconstruction
    Stephen F Badylak
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, 100 Technology Drive, Suite 200, Pittsburgh, PA 15219, USA
    Transpl Immunol 12:367-77. 2004
    ..The biologic response to these xenogeneic bioscaffolds, including the immune response, is discussed herein...
  6. ncbi Evaluation of anatomic valve opening and leaflet morphology in aortic valve bioprosthesis by using multidetector CT: comparison with transthoracic echocardiography
    Fabien Chenot
    Divisions of Cardiology and Radiology Cliniques Universitaires St Luc, Universite Catholique de Louvain, Avenue Hippocrate 10 2881, B 1200 Brussels, Belgium
    Radiology 255:377-85. 2010
    ....
  7. ncbi Porous scaffold design for tissue engineering
    Scott J Hollister
    Scaffold Tissue Engineering Group, Department of Biomedical Engineering, The University of Michigan, Ann Arbor, Michigan 41809, USA
    Nat Mater 4:518-24. 2005
    ....
  8. ncbi Performance of bioprostheses and mechanical prostheses assessed by composites of valve-related complications to 15 years after mitral valve replacement
    W R E Jamieson
    University of British Columbia, Vancouver, British Columbia, Canada
    J Thorac Cardiovasc Surg 129:1301-8. 2005
    ..The purpose of this study was to compare valve-related reoperation, morbidity (permanent impairment), and mortality between bioprostheses and mechanical prostheses for mitral valve replacement...
  9. ncbi Cardiac valvular surgery in dialysis patients: comparison of surgical outcome for mechanical versus bioprosthetic valves
    Kentaro Umezu
    Department of Cardiovascular Surgery, The Heart Institute of Japan, Tokyo Women s Medical University, Tokyo, 162 8666, Japan
    Gen Thorac Cardiovasc Surg 57:197-202. 2009
    ..There has been a changing preference for bioprosthetic valves over mechanical valves in dialysis patients, but there is still much controversy. We reviewed our 17-year experience and assessed the influence of prosthesis choice...
  10. ncbi Long-term survival of dialysis patients in the United States with prosthetic heart valves: should ACC/AHA practice guidelines on valve selection be modified?
    Charles A Herzog
    Cardiovascular Special Studies Center, US Renal Data System, Department of Internal Medicine, Division of Cardiology, University of Minnesota, Minneapolis 55415, USA
    Circulation 105:1336-41. 2002
    ....
  11. ncbi Aortic valve replacement with the Mitroflow pericardial bioprosthesis: durability results up to 21 years
    Charles A Yankah
    Deutsches Herzzentrum Berlin, Berlin, Germany
    J Thorac Cardiovasc Surg 136:688-96. 2008
    ..The study aim was to analyze the performance profile of a large series of Mitroflow pericardial valves (Sorin Group Canada Inc. Mitroflow Division) in the very long term...
  12. ncbi Comparison of cross-linked and non-cross-linked porcine acellular dermal matrices for ventral hernia repair
    Charles E Butler
    Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    J Am Coll Surg 211:368-76. 2010
    ..The newer non-cross-linked PADMs, however, have not been directly compared with cross-linked PADMs. We hypothesized that chemical cross-linking affects the biologic host response to PADMs used to repair ventral hernias...
  13. ncbi Hemodynamic characteristics of the Matrix P decellularized xenograft for pulmonary valve replacement during the Ross operation
    Wolfgang Konertz
    Charite Universitatsmedizin Berlin, Department of Cardiovascular Surgery, Berlin, Germany
    J Heart Valve Dis 14:78-81. 2005
    ..Alternatives to pulmonary valve replacement with homografts are needed. The study aim was to demonstrate the performance of a decellularized porcine xenograft valve (Matrix P) in adult patients after the Ross operation...
  14. pmc Transapical aortic valve replacement under real-time magnetic resonance imaging guidance: experimental results with balloon-expandable and self-expanding stents
    Keith A Horvath
    Cardiothoracic Surgery Research Program, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Eur J Cardiothorac Surg 39:822-8. 2011
    ..Whether there are different advantages to SE or BE stents is unknown. We report rtMRI-guided tAVI in a porcine model using both SE and BE stents, and compare the differences between the stents...
  15. ncbi Anti alpha-gal immune response following porcine bioprosthesis implantation in children
    Chun Soo Park
    Department of Thoracic and Cardiovascular Surgery, Seoul National University College of Medicine, Republic of Korea
    J Heart Valve Dis 19:124-30. 2010
    ..The study aim was to determine the anti alpha-Gal immune response following commercial porcine bioprosthesis implantation in children.
  16. ncbi Calcification of tissue heart valve substitutes: progress toward understanding and prevention
    Frederick J Schoen
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, The Harvard MIT Division of Health Sciences and Technology, Boston, Massachusetts 02115, USA
    Ann Thorac Surg 79:1072-80. 2005
    ....
  17. ncbi Treatment of destructive aortic valve endocarditis with the Freestyle Aortic Root Bioprosthesis
    Ludwig C Müller
    Department of Cardiac Surgery, University of Innsbruck, Innsbruck, Austria
    Ann Thorac Surg 75:453-6. 2003
    ..Homograft aortic roots are the conduits of choice, but because they are not available in all cases, alternative conduits are needed...
  18. ncbi Prospectively randomized evaluation of stentless versus conventional biological aortic valves: impact on early regression of left ventricular hypertrophy
    T Walther
    University Leipzig, Heartcenter, Department of Cardiac Surgery, Leipzig, Germany
    Circulation 100:II6-10. 1999
    ..The aim of this prospectively randomized study was to evaluate left ventricular hypertrophy and its regression after stentless versus conventional biological aortic valve replacement...
  19. ncbi One year hemodynamic performance of the Perimount Magna pericardial xenograft and the Medtronic Mosaic bioprosthesis in the aortic position: a prospective randomized study
    María José Dalmau
    Department of Cardiac Surgery, Salamanca University Hospital, Paseo de San Vicente 58 182, 37007 Salamanca, Spain
    Interact Cardiovasc Thorac Surg 6:345-9. 2007
    ..undergoing aortic valve replacement were prospectively assigned to receive either an EPM-valve (n=43) or an MM-bioprosthesis (n=43)...
  20. ncbi Structural deterioration of the Freestyle aortic valve: mode of presentation and mechanisms
    Siamak Mohammadi
    Department of Cardiac Surgery, Laval Hospital, Quebec City, Quebec, Canada
    J Thorac Cardiovasc Surg 132:401-6. 2006
    ..design features and anti-calcification treatment of the Freestyle (Medtronic Inc, Minneapolis, Minn) stentless bioprosthesis, development of structural valve deterioration may differ in comparison with other bioprosthetic valves...
  21. doi Guidelines for reporting mortality and morbidity after cardiac valve interventions
    Cary W Akins
    The American Association for Thoracic Surgery, Beverly, Massachusetts, USA
    Ann Thorac Surg 85:1490-5. 2008
  22. ncbi Heart valve tissue engineering
    Ivan Vesely
    The Saban Research Institute of Children s Hospital Los Angeles, Keck School of Medicine, University of Southern CaliforniaLos Angeles, CA 90027, USA
    Circ Res 97:743-55. 2005
    ..Alternative approaches to valvular tissue engineering, as well as the role of industry in shaping this field in the future, are also reviewed...
  23. ncbi Late outcomes for aortic valve replacement with the Carpentier-Edwards pericardial bioprosthesis: up to 17-year follow-up in 1,000 patients
    R Scott McClure
    Division of Cardiac Surgery, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Ann Thorac Surg 89:1410-6. 2010
    This study reviews a single institution experience with the Carpentier-Edwards pericardial aortic valve bioprosthesis, concentrating on late outcomes.
  24. ncbi Percutaneous aortic valve replacement for severe aortic stenosis in high-risk patients using the second- and current third-generation self-expanding CoreValve prosthesis: device success and 30-day clinical outcome
    Eberhard Grube
    HELIOS Heart Center Siegburg, Siegburg, Germany
    J Am Coll Cardiol 50:69-76. 2007
    ..We sought to determine both the procedural performance and safety of percutaneous implantation of the second (21-French [F])- and third (18-F)-generation CoreValve aortic valve prosthesis (CoreValve Inc., Irvine, California)...
  25. ncbi Minimally invasive versus standard approach aortic valve replacement: a study in 506 patients
    Ihsan Bakir
    Department of Cardiovascular Surgery, Siyami Ersek Thoracic and Cardiovascular Surgery Center, Istanbul, Turkey
    Ann Thorac Surg 81:1599-604. 2006
    ..Minimally invasive aortic valve replacement through partial upper sternotomy has been shown to reduce surgical trauma, and, supposedly, decrease postoperative pain, blood loss, and hospital stay...
  26. pmc Midterm results of transapical aortic valve replacement via real-time magnetic resonance imaging guidance
    Keith A Horvath
    National Heart, Lung, and Blood Institute, National Institutes of Health the Cardiothoracic Surgery Research Program, Bethesda, MD 20892, USA
    J Thorac Cardiovasc Surg 139:424-30. 2010
    ..To assist the surgeon and improve the success of the operation, we have performed transapical aortic valve replacements using real-time magnetic resonance imaging guidance...
  27. ncbi Hancock II bioprosthesis for aortic valve replacement: the gold standard of bioprosthetic valves durability?
    Tirone E David
    Division of Cardiovascular Surgery of Peter Munk Cardiac Centre, Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada
    Ann Thorac Surg 90:775-81. 2010
    This study examined the long-term durability of the Hancock II bioprosthesis (Medtronic, Minneapolis, MN) in the aortic position.
  28. ncbi Surgical aspects of endovascular retrograde implantation of the aortic CoreValve bioprosthesis in high-risk older patients with severe symptomatic aortic stenosis
    Bertrand Marcheix
    Department of Cardiovascular Surgery, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec, Canada
    J Thorac Cardiovasc Surg 134:1150-6. 2007
    ..We report our experience with retrograde endovascular bioprosthesis implantation with brief cardiopulmonary bypass support in high-risk older patients.
  29. ncbi Application of tissue-engineering principles toward the development of a semilunar heart valve substitute
    Christopher K Breuer
    Department of Pediatric Surgery, Yale University, New Haven, Connecticut, USA
    Tissue Eng 10:1725-36. 2004
    ..The last 10 years of investigation into a tissue-engineered heart valve as well as current developments are reviewed. Finally, the early clinical applications of cardiovascular tissue engineering are presented...
  30. ncbi Influence of patient-prosthesis mismatch on long-term results after aortic valve replacement with a stented bioprosthesis
    Jean M Frapier
    Department of Cardiac Surgery, Arnaud de Villeneuve Hospital, CHU, Montpellier, France
    J Heart Valve Dis 11:543-51. 2002
    ..The study aim was to compare long-term results of bioprostheses implanted in the aortic position, with and without patient-prosthesis mismatch (defined as effective orifice area (EOA)/body surface area (BSA) < or =0.85 cm2/m2)...
  31. ncbi Hemodynamic evaluation of the Sorin Soprano bioprosthesis in the completely supra-annular aortic position
    Walter B Eichinger
    German Heart Center Munich, Department of Cardiovascular Surgery, Munich, Germany
    J Heart Valve Dis 14:822-7. 2005
    The study aim was to evaluate the clinical and hemodynamic performance of the Sorin Soprano bioprosthesis in the aortic position.
  32. ncbi Mass regression in aortic stenosis after valve replacement with small size pericardial bioprosthesis
    Giordano Tasca
    Department of Cardiac Surgery, Hospital Poliambulanza, Brescia, Italy
    Ann Thorac Surg 76:1107-13. 2003
    The aim of the study was to determine whether left ventricular mass regression is influenced by valve size after the implantation of a Carpentier-Edwards Perimount (CEP) pericardial bioprosthesis for pure aortic stenosis.
  33. ncbi The effects of VARC-defined acute kidney injury after transcatheter aortic valve implantation (TAVI) using the Edwards bioprosthesis
    Muhammed Zeeshan Khawaja
    King s College London, BHF Centre of Research Excellence, Cardiovascular Division, The Rayne Institute, London, United Kingdom
    EuroIntervention 8:563-70. 2012
    ....
  34. ncbi Long-term clinical and echocardiographic follow-up of the Freestyle stentless aortic bioprosthesis
    Siamak Mohammadi
    Division of Cardiac Surgery, Quebec Heart and Lung University Institute, 2725 Chemin Ste Foy, Quebec City, Quebec, Canada G1V 4G5
    Circulation 126:S198-204. 2012
    ..The present report describes the outcomes of patients with the Freestyle stentless bioprosthesis followed for ≤18 years.
  35. ncbi Transcatheter bioprosthesis implantation for the treatment of aortic stenosis: three-year experience
    Fabio Sandoli de Brito Junior
    Hospital Israelita Albert Einstein, Sao Paulo, SP, Brasil
    Arq Bras Cardiol 99:697-705. 2012
    Transcatheter aortic bioprosthesis implantation is a new treatment modality for patients with aortic stenosis who are inoperable or at high surgical risk.
  36. ncbi Usefulness of the indexed effective orifice area at rest in predicting an increase in gradient during maximum exercise in patients with a bioprosthesis in the aortic valve position
    P Pibarot
    Quebec Heart Institute, Laval Hospital, Laval University, Sainte Foy, Quebec, Canada
    Am J Cardiol 83:542-6. 1999
    ..The relation found between the indexed effective orifice area at rest and the increase in gradient during exercise should be useful in predicting the hemodynamic behavior of a stented bioprosthesis during exercise.
  37. ncbi Percutaneous aortic valve implantation retrograde from the femoral artery
    John G Webb
    Division of Cardiology, St Paul s Hospital, Vancouver, British Columbia, Canada
    Circulation 113:842-50. 2006
    ..Retrograde prosthetic aortic valve implantation via the femoral artery has potential advantages. Percutaneous prosthetic aortic valve implantation via the femoral arterial approach is described and the initial experience reported...
  38. ncbi The valve-in-valve technique for treatment of aortic bioprosthesis malposition an analysis of incidence and 1-year clinical outcomes from the italian CoreValve registry
    Gian Paolo Ussia
    Ferrarotto Hospital, University of Catania, Catania, Italy
    J Am Coll Cardiol 57:1062-8. 2011
    ..We appraised the incidence and clinical outcomes of patients who were treated with the valve-in-valve (ViV) technique for hemodynamically destabilizing paraprosthetic leak (PPL)...
  39. ncbi Percutaneous implantation of the CoreValve self-expanding valve prosthesis in high-risk patients with aortic valve disease: the Siegburg first-in-man study
    Eberhard Grube
    Department of Cardiology Angiology, HELIOS Heart Center Siegburg, Ringstrasse 49, 53721 Siegburg, Germany
    Circulation 114:1616-24. 2006
    ..single-center, nonrandomized study was performed in high-risk patients with aortic valve disease to evaluate the feasibility and safety of percutaneous implantation of a novel self-expanding aortic valve bioprosthesis (CoreValve).
  40. ncbi Transcatheter transapical mitral valve-in-valve implantations for a failed bioprosthesis: a case series
    Anson W Cheung
    St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    J Thorac Cardiovasc Surg 141:711-5. 2011
    ..The operative mortality and morbidity associated with redo mitral surgery remains high. Transapical transcatheter mitral valve-in-valve implantation might offer an alternate and safer approach for high-risk patients...
  41. ncbi Comparison of bioprosthesis and mechanical valves, a meta-analysis of randomised clinical trials
    B Kassai
    Clinical Pharmacology Unit EA643, Cardiovascular Hospital, Rue Guillaume Paradin, BP 8071 69376, Cedex 08, Lyon, France
    Cardiovasc Surg 8:477-83. 2000
    ..of this meta-analysis was to compare the outcomes of patients who randomly received mechanical valves or bioprosthesis, over a long-term clinical follow-up...
  42. ncbi Perforation of the Valsalva sinus after implantation of Medtronic Freestyle aortic bioprosthesis
    Nobuchika Ozaki
    Kobe University Graduate School of Medicine, Division of Cardiovascular, Thoracic, and Pediatric Surgery, Kobe, Japan
    Ann Thorac Surg 82:2282-5. 2006
    We report on structural valve deterioration in patients with the Medtronic Freestyle aortic bioprosthesis (Medtronic, Inc, Minneapolis, MN), including spontaneous perforation of the Valsalva sinus...
  43. ncbi Heart valve replacement for patients with end-stage renal disease in Japan
    Yoshio Misawa
    Division of Cardiovascular Surgery, Jichi Medical University, Shimotsuke, Tochigi, Japan
    Ann Thorac Cardiovasc Surg 16:4-8. 2010
    ..The life expectancy of dialysis patients in Japan is relatively high. The potential risk of early calcification of bioprosthetic valves should be taken into account when choosing prosthetic heart valves for these patients in Japan...
  44. ncbi Treatment of a degenerative stenosed CoreValve(®) aortic bioprosthesis by transcatheter valve-in-valve insertion
    Christoph Hammerstingl
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Bonn, Bonn, Germany
    Catheter Cardiovasc Interv 79:748-55. 2012
    ..The long-term durability of the bioprosthesis is unknown...
  45. ncbi Left ventricular remodeling, hemodynamics and early clinical outcomes after aortic valve replacement with the Pericarbon Freedom stentless bioprosthesis: results from the Italian Prospective Multicenter Trial
    Augusto D'Onofrio
    Division of Cardiac Surgery, San Bortolo Hospital, Vicenza, Italy
    J Heart Valve Dis 20:531-9. 2011
    ..outcomes of patients undergoing aortic valve replacement (AVR) with the Pericarbon Freedom (PF) stentless bioprosthesis; and (ii) the impact of the two suture techniques--continuous and interrupted--on the hemodynamic performance ..
  46. ncbi A 25-year experience with Carpentier-Edwards Perimount in the mitral position
    Kouakou Gregoire Ayegnon
    Department of Cardiovascular and Thoracic Surgery, Hospital University of Tours, Tours, France
    Asian Cardiovasc Thorac Ann 19:14-9. 2011
    Data of 401 patients who underwent mitral valve replacement with the Carpentier-Edwards Perimount bioprosthesis between 1984 and 2009 were evaluated. Their mean age was 68.1 ± 10.4 years (range, 22-90 years) and 54.9% were female...
  47. ncbi Valve replacement in patients on chronic renal dialysis: implications for valve prosthesis selection
    William T Brinkman
    Joseph B Whitehead Department of Surgery, Emory University School of Medicine, Atlanta, Georgia, USA
    Ann Thorac Surg 74:37-42; discussion 42. 2002
    ..Reports are sparse describing heart valve replacement in patients with end-stage renal disease. This review assesses a 15-year experience and outcomes after valve replacement in patients on chronic preoperative renal dialysis...
  48. pmc Effect of surgeon on transprosthetic gradients after aortic valve replacement with Freestyle stentless bioprosthesis and its consequences: a follow-up study in 587 patients
    Alexander Albert
    Department of Cardiac Surgery, Heart Institute Lahr Baden, Hohbergweg 2, 77933 Lahr Germany
    J Cardiothorac Surg 2:40. 2007
    ..We studied systematically the role of surgeons and other possible determinants for mid-term survival, postoperative gradients and Quality of Life (QoL) after aortic valve replacement (AVR) with Freestyle stentless bioprostheses...
  49. ncbi Anatomic and procedural predictors of paravalvular aortic regurgitation after implantation of the Medtronic CoreValve bioprosthesis
    Mohammad A Sherif
    Heart and Vascular Center, Segeberger Kliniken GmbH, Academic Teaching Hospital of the University of Kiel, Bad Segeberg, Germany
    J Am Coll Cardiol 56:1623-9. 2010
    ..The purpose of this study was to determine the predictors of aortic regurgitation (AR) after transcatheter aortic valve implantation (TAVI)...
  50. ncbi Evaluation of the matrix-synthesis potential of crosslinked hyaluronan gels for tissue engineering of aortic heart valves
    A Ramamurthi
    Department of Bioengineering, Clemson University, Clemson, SC, USA
    Biomaterials 26:999-1010. 2005
    ..We have thus demonstrated that hylan gels are useful as substrates to induce elastin synthesis in culture to obtain structures that resemble the elastin matrix of the native aortic valve...
  51. ncbi Aortic bioprosthetic valve deterioration 8 months after implantation
    Dominik Wiedemann
    University Clinic of Cardiac Surgery, Innsbruck Medical University, Innsbruck, Austria
    Ann Thorac Surg 89:277-9. 2010
    One year after aortic bioprosthetic valve replacement with a 23-mm Epic bioprosthesis (St. Jude Medical, St...
  52. ncbi Transcatheter valve repair/implantation
    Robert J Siegel
    The Heart Institute, Cedars Sinai Medical Center, 8700 Beverly Blvd, Room 5623, Los Angeles, CA 90048, USA
    Int J Cardiovasc Imaging 27:1165-77. 2011
    ..Use of 3D TEE has proven to be a substantial advance for evaluating patients prior to percutaneous heart valve procedures and especially for guiding and monitoring percutaneous, transcatheter heart valve procedures...
  53. ncbi A single center experience with the freestyle bioprosthesis: midterm results at the Québec Heart Institute
    F Dagenais
    Department of Cardiothoracic Surgery, , , Canada
    Semin Thorac Cardiovasc Surg 13:156-62. 2001
    ..This study reports midterm follow-up in 419 patients in which a Freestyle bioprosthesis (Medtronic Heart Valves, Minneapolis, MN) was inserted between January 1993 and January 2000 at the Quebec ..
  54. ncbi St Jude Medical Epic porcine bioprosthesis: results of the regulatory evaluation
    W R Eric Jamieson
    University of British Columbia, Vancouver, British Columbia, Canada
    J Thorac Cardiovasc Surg 141:1449-54.e2. 2011
    ..Epic heart valve (St Jude Medical, Inc, St Paul, Minn) is a tricomposite glutaraldehyde-preserved porcine bioprosthesis. The St Jude Medical Biocor porcine bioprosthesis is the precursor valve to the St Jude Medical Epic valve...
  55. ncbi Proximal thoracic aortic replacement for aneurysmal disease using the freestyle stentless bioprosthesis: a 10-year experience
    Sebastian Pagni
    Division of Thoracic and Cardiovascular Surgery, University of Louisville, Louisville, Kentucky 40202, USA
    Ann Thorac Surg 92:873-9. 2011
    Porcine bioprosthesis (bioroots) are an attractive surgical strategy for ascending aorta and arch replacement. This study evaluated the perioperative and late outcomes using this strategy for proximal aortic aneurysmal disease.
  56. ncbi The extended Biocor stentless aortic bioprosthesis. Early clinical experience
    G Dellgren
    Karolinska Hospital, Department of Surgical Sciences, Karolinska Institute, Stockholm, Sweden
    Scand Cardiovasc J 33:259-64. 1999
    In the "Extended" Biocor stentless aortic bioprosthesis, supra- and subvalvular extensions to a bovine pericardium ring carry three porcine leaflets...
  57. ncbi Human versus non-cross-linked porcine acellular dermal matrix used for ventral hernia repair: comparison of in vivo fibrovascular remodeling and mechanical repair strength
    Kristin Turza Campbell
    Department of Plastic Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Plast Reconstr Surg 127:2321-32. 2011
    ..Direct comparisons between the two in vivo are lacking, however. This study compared clinically relevant early outcomes with these bioprosthetic materials when used for ventral hernia repair...
  58. ncbi Early aortic bioprosthetic valve deterioration in an octogenarian
    Hironori Izutani
    Division of Cardiovascular Surgery, National Hospital Organization Kure Medical Center, Hiroshima, Japan
    Ann Thorac Surg 86:1369-71. 2008
    ..We could not identify the possible reason for this devastating complication; however, daily calcium supplement consumption may play a role of acceleration of calcium deposition in the leaflets of implanted bioprosthetic heart valves...
  59. ncbi Surgical therapy in patients with active infective endocarditis: seven-year single centre experience in a subgroup of 255 patients treated with the Shelhigh stentless bioprosthesis
    Michele Musci
    Deutsches Herzzentrum Berlin, Department of Cardiothoracic and Vascular Surgery, Augustenburger Platz 1, Berlin, Germany
    Eur J Cardiothorac Surg 34:410-7. 2008
    ..We aimed to identify independent risk factors for early mortality...
  60. ncbi Transcatheter aortic valve replacement for degenerative bioprosthetic surgical valves: results from the global valve-in-valve registry
    Danny Dvir
    Washington Hospital Center, 110 Irving St NW, Suite 4B 1, Washington, DC 20010, USA
    Circulation 126:2335-44. 2012
    ..aortic valve-in-valve implantation is an emerging therapeutic alternative for patients with a failed surgical bioprosthesis and may obviate the need for reoperation...
  61. ncbi Clinical experience with the ATS 3f Enable® Sutureless Bioprosthesis
    Sven Martens
    Department for Thoracic and Cardiovascular Surgery, Johann Wolfgang Goethe University, Frankfurt, Germany
    Eur J Cardiothorac Surg 40:749-55. 2011
    The ATS 3f Enable® Bioprosthesis is a self-expanding valve with a tubular design that allows for decreased leaflet stress and preservation of aortic sinuses...
  62. ncbi Clinical experience with the ATS 3F stentless aortic bioprosthesis: five years' follow up
    Jörg Linneweber
    Klinik für Kardiovaskuläre Chirurgie, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Heart Valve Dis 19:772-7. 2010
    The ATS 3F aortic bioprosthesis is an equine pericardial stentless valve used for aortic valve replacement (AVR). The study aim was to determine the incidence of valve-related events during a five-year follow up period.
  63. ncbi Results of isolated valve replacement in hemodialysis patients
    Wataru Kato
    Department of Cardiothoracic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Asian Cardiovasc Thorac Ann 15:386-91. 2007
    ..6% at 3 years and 76.7% at 5 years. One patient with a bioprosthesis experienced structural valvular deterioration after 3 years...
  64. ncbi Long-term follow-up of cardiac valve replacement using bioprosthesis in patients 70 years old and older
    Keishi Ueyama
    Department of Cardiovascular Surgery, Maizuru Mutual Hospital, Japan
    Artif Organs 26:1059-62. 2002
    ..0% for mitral valves. The average lifespan in Japan is currently 77.64 years for men and 84.62 years for women; therefore, valve degeneration in patients who receive bioprosthesis replacement in their early 70s should be anticipated.
  65. ncbi Aortic root replacement with the freestyle stentless porcine aortic root bioprosthesis
    N D Kon
    Department of Cardiothoracic Surgery, Wake Forest University School of Medicine Baptist Medical Center, Winston Salem, North Carolina 27157 1096, USA
    Ann Thorac Surg 67:1609-15; discussion 1615-6. 1999
    ..Stentless porcine prosthetic valves offer several advantages over traditional valves. Among these are superior hemodynamics, laminar flow patterns, lack of need for anticoagulation and perhaps improved durability...
  66. ncbi Heart valve prosthesis selection in patients with end-stage renal disease requiring dialysis: a systematic review and meta-analysis
    Vincent Chan
    Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    Heart 97:2033-7. 2011
    ..There is little evidence guiding heart valve prosthesis selection in patients with end-stage renal disease (ESRD) on dialysis...
  67. pmc Tropheryma whipplei Infection of an acellular porcine heart valve bioprosthesis in a patient who did not have intestinal Whipple's disease
    Jens Dreier
    Institut fur Laboratoriums und Transfusionsmedizin, Herz und Diabeteszentrum Nordrhein Westfalen, Universitatsklinik der Ruhr Universitat Bochum, Bad Oeynhausen, Germany
    J Clin Microbiol 42:4487-93. 2004
    ..First, a PCR with broad-range primers identified the complete 16S ribosomal DNA of T. whipplei in bioprosthesis tissue...
  68. ncbi Crosslinked hyaluronan scaffolds as a biologically active carrier for valvular interstitial cells
    Kristyn S Masters
    Howard Hughes Medical Institute, University of Colorado, Boulder, CO 80309 0424, USA
    Biomaterials 26:2517-25. 2005
    ..This work shows promise for the creation of a tissue-engineered heart valve utilizing the synergistic relationship between hyaluronic acid and VICs...
  69. ncbi The stentless freestyle bioprosthesis: impact of age over 80 years on quality of life, perioperative, and mid-term outcome
    Jürgen Ennker
    Heart Institute Lahr Baden, Lahr, Germany
    J Card Surg 21:379-85. 2006
    ..The steadily increasing life expectancy of the population in the Western World, together with the progress in noninvasive diagnostic methods and operating techniques lead to an increase in aortic valve surgery in elderly people...
  70. ncbi Transcatheter aortic valve implantation for high risk patients with severe aortic stenosis using the Edwards Sapien balloon-expandable bioprosthesis: a single centre study with immediate and medium-term outcomes
    Mark D Osten
    Department of Medicine, Division of Cardiology, University Health Network, Toronto General Hospital, Toronto, Ontario, Canada
    Catheter Cardiovasc Interv 75:475-85. 2010
    ..Transcatheter aortic valve implantation (TCAVI) is an emerging alternative therapy to open-heart surgery in high-risk patients with symptomatic aortic stenosis...
  71. pmc Mid term outcome and quality of life after aortic valve replacement in elderly people: mechanical versus stentless biological valves
    I Florath
    Herzzentrum Lahr Baden, Lahr, Germany
    Heart 91:1023-9. 2005
    ..To assess the benefit for patients older than 65 years of aortic valve replacement with stentless biological heart valves in comparison with mechanical valves...
  72. ncbi The late impact of surgical skills and training on the subcoronary implantation of the Freestyle stentless bioprosthesis
    Alexander Albert
    Department of Cardiac Surgery, Heart Institute Lahr Baden, Lahr, Germany
    J Heart Valve Dis 19:104-12; discussion 113-4. 2010
    ..an impact of higher postoperative mean pressure gradient (MPG) across the subcoronary Freestyle stentless bioprosthesis on the mid-term quality of life, but not on that of survival...
  73. ncbi Prosthesis-patient mismatch after transcatheter aortic valve implantation with the Medtronic-Corevalve bioprosthesis
    Hasan Jilaihawi
    Department of Cardiology, Glenfield Hospital, Leicester LE3 9QP, UK
    Eur Heart J 31:857-64. 2010
    ..The aims of this study were to report its incidence and determinants following transcatheter aortic valve implantation (TAVI) with the Corevalve bioprosthesis, which have-thus far-not been described.
  74. doi Choice of prosthetic heart valve in today's practice
    Reida El Oakley
    Department of Surgery, Prince Sultan Cardiac Centre, Riyad, Saudi Arabia
    Circulation 117:253-6. 2008
  75. ncbi The bioprosthesis type and size influence the postoperative incidence of permanent pacemaker implantation in patients undergoing aortic valve surgery
    Maqsood Elahi
    Department of Cardiothoracic Surgery, Punjab Institute of Cardiology, Jail Road, Lahore, Pakistan
    J Interv Card Electrophysiol 15:113-8. 2006
    ..Though stentless bioprosthesis show better haemodynamic profiles compared with stented, yet debate exists about the differential effects of ..
  76. ncbi A 20-year experience of 1712 patients with the Biocor porcine bioprosthesis
    Pia S U Mykén
    Department of Thoracic and Cardiovascular Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden
    J Thorac Cardiovasc Surg 137:76-81. 2009
    ..data from the ongoing long-term study of the St Jude Medical Biocor (St Jude Medical, St Paul, Minn) porcine bioprosthesis are reported. Earlier follow-ups have shown that the valve has excellent durability...
  77. ncbi Long-term results of the bioprosthesis in elderly patients: impact on quality of life
    D F Pupello
    St Joseph Heart Institute, Tampa, Florida
    Ann Thorac Surg 71:S244-8. 2001
    ..A wealth of data exists on acceptable mortality and morbidity for valve operations in older patients, yet information documenting quality of life is lacking...
  78. ncbi Twenty-year results of the Hancock II bioprosthesis
    Michael A Borger
    Division of Cardiovascular Surgery, Toronto General Hospital, University Health Network, and Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    J Heart Valve Dis 15:49-55; discussion 55-6. 2006
    The Hancock II bioprosthesis (HII) has several design features designed to increase its durability. The study aim was to determine very long-term outcomes for the HII valve in a large patient population.
  79. ncbi Biological versus mechanical aortic valve replacement in children
    M W Turrentine
    Section of Cardiothoracic Surgery, James W Riley Hospital for Children, and Indiana University School of Medicine, Indianapolis 46202 5123, USA
    Ann Thorac Surg 71:S356-60. 2001
    ..Potential risks of anticoagulation with mechanical valves and degeneration of other biological substitutes have kindled interest in the Ross procedure. This study outlines the evolution of our 27-year experience with prosthetic devices...
  80. ncbi Risk factors for atherosclerosis and the degeneration of pericardial valves after aortic valve replacement
    Georg Nollert
    Department of Cardiac Surgery, University of Munich, Munich, Germany
    J Thorac Cardiovasc Surg 126:965-8. 2003
    ....
  81. ncbi Aortic root replacement in adolescents and young adults: composite graft versus homograft or autograft
    G B Luciani
    Division of Cardiac Surgery, University of Verona, Italy
    Ann Thorac Surg 66:S189-93. 1998
    ..To identify the "ideal" substitute for ARR in the young, clinical results in teenagers and young adults (<35 years) operated on in the past two decades were reviewed...
  82. ncbi Carpentier-Edwards PERIMOUNT Magna bioprosthesis: a stented valve with stentless performance?
    Pasquale Totaro
    Cardiac Surgery Division, Regional Cardiac Centre, Morriston Hospital, Swansea, United Kingdom
    J Thorac Cardiovasc Surg 130:1668-74. 2005
    ..to evaluate the early hemodynamic performance of the recently introduced Carpentier-Edwards PERIMOUNT Magna bioprosthesis (Edwards Lifesciences, Irvine, Calif) and compare it with those of the conventional Carpentier-Edwards ..
  83. ncbi Are allografts the biologic valve of choice for aortic valve replacement in nonelderly patients? Comparison of explantation for structural valve deterioration of allograft and pericardial prostheses
    Nicholas G Smedira
    Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Thorac Cardiovasc Surg 131:558-564.e4. 2006
    ..To compare explantation for structural valve deterioration in nonelderly patients after aortic valve replacement with stented bovine pericardial and cryopreserved allograft valves...
  84. ncbi Prosthetic valve endocarditis
    Balakrishnan Mahesh
    Cardiothoracic Center, Bristol Royal Infirmary, Bristol, United Kingdom
    Ann Thorac Surg 80:1151-8. 2005
    ..This comprehensive review addresses various issues involved in the management of this complication...
  85. ncbi Long-term results after aortic valve replacement with the Bravo 400 stentless xenograft
    GianLuca Polvani
    Department of Cardiac Surgery and Cardiology, University of Milan, Centro Cardiologico Monzino IRCCS, Milan, Italy
    Ann Thorac Surg 80:495-501. 2005
    ..This study was undertaken to evaluate the long-term clinical and echocardiographic outcome after aortic valve replacement with the Bravo Cardiovascular Model 400 stentless xenograft...
  86. ncbi Are stentless valves superior to modern stented valves? A prospective randomized trial
    Ayyaz Ali
    Department of Cardiothoracic Surgery, Papworth Hospital, Papworth Everard, Cambridge, CB3 8RE, UK
    Circulation 114:I535-40. 2006
    ..It is presumed that stentless aortic bioprostheses are hemodynamically superior to stented bioprostheses. A prospective randomized controlled trial was undertaken to compare stentless versus modern stented valves...
  87. ncbi CryoLife-O'Brien stentless valve: 10-year results of 402 implants
    Mark F O'Brien
    Department of Cardiac Surgery, Brisbane, Australia
    Ann Thorac Surg 79:757-66. 2005
    ..This truly stentless porcine valve is composite, without Dacron, and implanted supra-annularly. Ten-year analysis with magnetic resonance imaging is presented...
  88. ncbi Ten-year outcome after aortic valve replacement with the freestyle stentless bioprosthesis
    David S Bach
    Division of Cardiology, Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Ann Thorac Surg 80:480-6; discussion 486-7. 2005
    ..The present report describes the clinical and hemodynamic outcomes for the Freestyle aortic root bioprosthesis in a large, multicenter cohort prospectively followed up for 10 years.
  89. ncbi Stentless vs. stented aortic valve replacement: left ventricular mass regression
    Muhammed Tamim
    Heart Centre, Cardiac Surgery Department, University Hospital Ghent, Ghent, Belgium
    Asian Cardiovasc Thorac Ann 13:112-8. 2005
    ..Stentless and stented bioprostheses both showed good early and late clinical and hemodynamic outcomes, with the advantage of better midterm survival for stentless xenografts...
  90. ncbi Eight-year results of Freestyle stentless bioprosthesis in the aortic position: a single-center study of 500 patients
    Philippe H Deleuze
    St Joseph Hospital, Paris, France
    J Heart Valve Dis 15:247-52. 2006
    ..Stentless bioprostheses may be the future valve of choice for aortic valve replacement (AVR). The study aim was to investigate mid-term clinical outcome after AVR with the Medtronic Freestyle valve...
  91. ncbi The Edwards Prima stentless valve: hemodynamic performance at one year
    U Bortolotti
    Department of Cardiology, Angiology and Pneumology, University of Pisa Medical School, Italy
    Ann Thorac Surg 68:2147-51. 1999
    ..The purpose of this study was to evaluate the hemodynamic performance of the EPSV 1 year after aortic valve replacement...
  92. ncbi Which patients benefit from stentless aortic valve replacement?
    Helmut Gulbins
    Department of Cardiovascular Surgery, University Heart Center, University Hospital Eppendorf, Hamburg, Germany
    Ann Thorac Surg 88:2061-8. 2009
    ..answer the question of whether stentless aortic bioprostheses possess proven advantages compared with stented bioprosthesis, and which patients might benefit from stentless valve implantation...
  93. ncbi Treatment of an aortic fungal false aneurysm by composite stentless porcine/pericardial conduit: a case report
    B Mahesh
    Bristol Heart Institute, Bristol Royal Infirmary, Bristol, BS2 8HW, UK
    Cardiovasc Surg 11:93-5. 2003
    ..Millburn, NJ) stentless porcine pericardial valved conduit...
  94. ncbi The Ross procedure: a systematic review and meta-analysis
    Johanna J M Takkenberg
    Department of Cardiothoracic Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands
    Circulation 119:222-8. 2009
    ..A systematic review of evidence on outcome after the Ross procedure may improve insight into outcome and potential determinants...
  95. ncbi Stentless valves versus stented bioprostheses at the aortic position: midterm results
    Sumit Narang
    Department of Cardiothoracic and Vascular Surgery, GB Pant Hospital, Maulana Azad Medical College, New Delhi, India
    J Thorac Cardiovasc Surg 136:943-7. 2008
    ..Our aim was to compare stentless and stented bioprostheses. Clinical outcomes, hemodynamic performance, and postoperative left ventricular mass regression were the principal outcomes assessed...
  96. ncbi Sutureless aortic valve replacement with the 3f Enable aortic bioprosthesis
    Sven Martens
    Department of Thoracic and Cardiovascular Surgery, JW Goethe University Hospital, Frankfurt, Germany
    Ann Thorac Surg 87:1914-7. 2009
    ..We report on clinical experiences with the sutureless, nitinol-stented 3f Enable (ATS Medical, Minneapolis, MN) aortic valve prosthesis in 32 patients...
  97. ncbi Limited long-term durability of the Cryolife O'Brien stentless porcine xenograft valve
    Daisy Pavoni
    Department of Cardiopulmonary Sciences, Azienda Ospedaliero Universitaria Santa Maria della Misericordia, P le S Maria della Misericordia 15, 33100 Udine, Italy
    Circulation 116:I307-13. 2007
    ..Accordingly, we analyzed 10-year outcomes after aortic valve replacement with this valve...
  98. ncbi Prognosis after aortic valve replacement with a bioprosthesis: predictions based on meta-analysis and microsimulation
    J P Puvimanasinghe
    Center for Clinical Decision Sciences, Department of Public Health, Erasmus University Medical Center, Rotterdam, The Netherlands
    Circulation 103:1535-41. 2001
    ..actual risks of reoperation and valve-related events of patients after aortic valve replacement with a porcine bioprosthesis. METHODS AND RESULTS: We conducted a meta-analysis of 9 selected reports on stented porcine bioprostheses, ..
  99. ncbi Aortic valve replacement with the Sorin Pericarbon Freedom stentless prosthesis: 7 years' experience in 130 patients
    Augusto D'Onofrio
    Division of Cardiac Surgery, San Bortolo Hospital, Vicenza, Italy
    J Thorac Cardiovasc Surg 134:491-5. 2007
    ..The aim of this single-center retrospective study was to assess midterm clinical and hemodynamic results of aortic valve replacement with the Sorin Pericarbon Freedom stentless bioprosthesis.
  100. ncbi Recellularization of decellularized mitral heart valves in juvenile pigs
    Jesper L Hønge
    Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Skejby, Denmark
    J Heart Valve Dis 19:584-92. 2010
    ..The study aim was to determine the degree of recellularization and calcification in DOA-treated heart valve prostheses in the mitral position in juvenile pigs...
  101. ncbi Evidence of mitigated calcification of the Mosaic versus Hancock Standard valve xenograft in the mitral position of young sheep
    Patricia A Weber
    International Heart Institute of Montana Foundation at Saint Patrick Hospital and Health Sciences Center and The University of Montana, Missoula, Mont, USA
    J Thorac Cardiovasc Surg 132:1137-43. 2006
    ..A comparative animal study was undertaken to evaluate the behavior of a new-generation porcine bioprosthesis in contrast with a first-generation porcine bioprosthesis...

Research Grants49

  1. Development of a Surgical and Transcatheter Polymeric Heart Valve
    JACK CABELL GRIFFIS; Fiscal Year: 2012
    ..have been implanted since 1980 in the United States alone, but the solution for a durable, non-calcifying bioprosthesis still eludes us...
  2. Exchangeable Heart Valve for Tissue Engineering Applications
    Ivan Vesely; Fiscal Year: 2007
    ..hand, because anticoagulation-related complications and used only if the patient is too young to receive a bioprosthesis. The issue that drives the decision for a mechanical or bioprosthetic valve is the risk of reoperation - ..
  3. A Bioinspired Small Diameter Vascular Conduit
    Elliot Chaikof; Fiscal Year: 2010
    ..durable small diameter vascular graft may be achievable by optimizing the mechanical properties of an arterial bioprosthesis, as well as other biologically related characteristics...
  4. Arterial-Mimetic Grants Molded from Purified Proteins
    DAVID MASTERS; Fiscal Year: 2003
    ..is that implantation of Vasograft TM in arterial circulation will result in a functional and durable vascular bioprosthesis. The biologic nature of this graft will facilitate native cellular in-growth and potential "neovessel" ..
  5. Prospective Investigation for Pulmonary Embolism Dx III
    Paul Stein; Fiscal Year: 2008
    ..abstract_text> ..
  6. PROSPECTIVE INVESTIGATION OF PULMONARY EMBOLISM DX-II
    Paul Stein; Fiscal Year: 2003
    ..4) The team of investigators is strong, and has collaborated previously in successful research in PE. ..
  7. Mechanobiology and Regenerative Medicine
    Michael S Sacks; Fiscal Year: 2010
    ..A timeline for completion of these studies, hypotheses to drive the specific aims, alternative approaches for completion of the work, and quantitative criteria for success are provided. ..
  8. Mechanisms of ECM Scaffold Remodeling
    Stephen Badylak; Fiscal Year: 2006
    ..The work will be conducted by an experienced interdisciplinary team of scientists and a timeline is presented for completion of the work. ..
  9. ENTERIC PHYSIOLOGY OF THE TRANSPLANTED GUT
    Michael Sarr; Fiscal Year: 2007
    ..This proposal will define important, novel neural mechanisms regulating motor and absorptive function in the denervated gut. Selected aspects have translational value to clinical gut transplantation. [unreadable] [unreadable]..
  10. ORIGIN OF CELLS THAT REPOPULATE RESORBABLE ECM SCAFFOLDS
    Stephen Badylak; Fiscal Year: 2001
    ..abstract_text> ..
  11. PATHOBIOLOGY OF CEREBRAL CAVERNOUS MALFORMATION
    Richard Lifton; Fiscal Year: 2002
    ..They have established a collection of these lesions and have begun developing cell cultures of different cell lines from lesions in order to pursue this aim. ..
  12. Development and Clinical Testing of CorAide RVAD/BVAD
    Kiyotaka Fukamachi; Fiscal Year: 2008
    ..The successful completion of this program will provide clinicians and patients with a safe and effective option for outpatient mechanical support that allows an excellent quality of life. ..
  13. Nano Fibers for ADME/Toxicology
    Peter Ma; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  14. CHIMERIC KIDNEY
    MARC HAMMERMAN; Fiscal Year: 2001
    ..Since transplanted metanephroi appear to be less immunogenic than adult kidneys, our studies will provide insight into the feasibility of a novel means of renal transplantation that could be applied to humans. ..
  15. Optimizing Mandibular Scaffold Modulus/Porosity Balance
    Scott Hollister; Fiscal Year: 2009
    ..This information will provide guidelines for designing scaffolds to optimize transition from scaffold load bearing to bone regeneration and load bearing. ..
  16. Orchestrating Bone Regeneration on Multiple Scales
    Peter X Ma; Fiscal Year: 2010
    ..SA 3. Confirm that the multi-scaled and factor-releasing scaffolds (selected from Aims 1&2) afford a superior environment for vascularized bone regeneration in a rat critical defect model. ..
  17. EFFECTS OF AGE ON SIGNALING IN HUMAN OSTEOBLASTOGENESIS
    Julie Glowacki; Fiscal Year: 2010
    ....
  18. Cell Recruitment Induced by ECM Scaffold Degradation
    Stephen F Badylak; Fiscal Year: 2010
    ..The objectives of the studies, the hypothesis upon which the experimental design is based, and a timeline for completion of the studies are presented. ..
  19. Tissue Engineered Nanofibrous Vascular Graft
    Song Li; Fiscal Year: 2010
    ..The accomplishment of this project will lead to the development of innovative technologies to engineer stem cells and nanofibrous scaffolds for the construction of small TEVGs. ..
  20. Annular and Sub-Valvular Repair Techniques for Ischemic Mitral Regurgitation: In-
    Ajit P Yoganathan; Fiscal Year: 2010
    ..abstract_text> ..
  21. TISSUE ENGINEERING OF GROWING JOINTS
    Julie Glowacki; Fiscal Year: 2002
    ..In vivo fate of engineered joints will be assessed in our model of murine joint transplantation and will be further verified in the pig. ..
  22. CHIMERIC KIDNEY
    MARC HAMMERMAN; Fiscal Year: 2003
    ..Our studies will provide insight into the physiology and feasibility of a novel means of renal transplantation that could be applied to humans. ..
  23. Proteomic Profiling of Stem Cell Differentiation
    Song Li; Fiscal Year: 2005
    ..The successful accomplishment of the goals will have high impact on stem cell engineering, and provide a rational basis for engineering BMMSC for vascular tissue repair. ..
  24. Biomimetic Nano Scaffolds
    Peter Ma; Fiscal Year: 2004
    ..This knowledge will enable us to develop a predictable biomimetic scaffold for in vivo application and will be the basis for our planned R01 investigation. ..
  25. BIOENGINEERING OF BLADDER TISSUES
    Anthony Atala; Fiscal Year: 2003
    ..In this aim we will attempt to determine the phenotypic and functional characteristics, over time, of the bioengineered bladder tissues, as compared to controls. ..
  26. 8th Conference - Chemistry & Biology Mineralized Tissue
    WILLIAM LANDIS; Fiscal Year: 2004
    ....
  27. ENHANCED DURABILITY OF BIOPROSTHETIC HEART VALVES
    Michael Sacks; Fiscal Year: 2004
    ..Determine how chemical treatment alters cuspal layer micromechanics. 2. Quantify PBHV cuspal deformation during the cardiac cycle. 3. Determine how long-term cyclic fatigue alters PBHV later structure and mechanical properties. ..
  28. NanobioReactor for monitoring small cell populations
    Ales Prokop; Fiscal Year: 2003
    ..abstract_text> ..
  29. Cardiac MR of Subclin CVD: Impact of Age
    WARREN MANNING; Fiscal Year: 2005
    ....
  30. MINERAL-MATRIX RELATIONS IN CALCIFYING TISSUES
    WILLIAM LANDIS; Fiscal Year: 2006
    ....
  31. LIPOPROTEINS MODULATE THE HEPATIC RESPONSE TO ENDOTOXIN
    Hobart Harris; Fiscal Year: 2008
    ..abstract_text> ..
  32. Mechanobiology of Mesenchymal Stem Cells
    Song Li; Fiscal Year: 2007
    ..g., using BMMSC-derived SMCs to construct tissue-engineered vascular grafts. ..
  33. Effect of Aging & Vitamin D Status on Osteoblastogenesis
    Julie Glowacki; Fiscal Year: 2008
    ..abstract_text> ..
  34. DESIGNED SCAFFOLD ARCHITECTURE AFFECTS BONE REGENERATION
    Scott Hollister; Fiscal Year: 2003
    ..Results from this study will assist us in optimizing biomaterial scaffold performance via computational design to enhance regenerate tissue structure and function via tissue engineering treatments. ..
  35. ORIGIN OF CELLS THAT REPOPULATE RESORBABLE ECM SCAFFOLDS
    Stephen Badylak; Fiscal Year: 2003
    ..abstract_text> ..
  36. Insulin Producing Cells from Amniotic Stem Cells for Diabetes Therapy
    Anthony Atala; Fiscal Year: 2009
    ..Successful development of an abundant source of transplantable insulin producing cells potentially would have a profound impact on the treatment of a major public health problem. ..
  37. Logical Analysis of Data and Cardiac Surgery Risk
    Eugene Blackstone; Fiscal Year: 2006
    ..Hence, the applicability of this work goes beyond determination of risk of patients undergoing cardiac surgery. ..
  38. Improving Flow Dynamics in Fontan Surgeries
    Ajit Yoganathan; Fiscal Year: 2006
    ....
  39. Mitral Annular Remodeling for MR Therapy
    Kiyotaka Fukamachi; Fiscal Year: 2005
    ..Therefore, this proposed research program is an important first step in this novel procedure's development as one potential therapeutic option for high-risk CHF patients with functional MR. ..
  40. Engineering Joint Scaffolds for Function/Regeneration
    Scott Hollister; Fiscal Year: 2005
    ..The remaining four specific aims are to investigate the performance of these scaffolds mechanically and using subcutaneous models, resulting in the in vivo minipig test of a prototype CRU. ..
  41. Cellular Remodeling of ECM Scaffolds
    Stephen Badylak; Fiscal Year: 2009
    ..We have identified clearly defined specific aims with quantifiable end points and an efficient three year timeline to conduct this work. ..
  42. Cleveland Clinic Orthopaedic Research Training Grant
    JOSEPH IANNOTTI; Fiscal Year: 2008
    ..abstract_text> ..
  43. Cell phenotype-controlled mechanical signaling of MSCs
    David Butler; Fiscal Year: 2004
    ..This technology can dramatically reduce time/expense during the development phase of TE fibrocartilage. ..
  44. Fluid Mechanics of the Mitral Valve: In Vitro Studies
    Ajit Yoganathan; Fiscal Year: 2004
    ..The use of state of the art measurement systems unavailable for in vivo use will yield significant results. ..
  45. "In Vitro Mechanical Stimulation to Enhance Tendon Repair"
    David Butler; Fiscal Year: 2009
    ..Our novel, interactive in vitro / in vivo study should help to develop in vitro predictors of in vivo repair outcome after surgery that also apply to other tissue systems. ..
  46. Tissue Engineering Evaluation Criteria for Musculoskeletal Tissue Repair
    David Butler; Fiscal Year: 2007
    ..abstract_text> ..
  47. Robotic Simulation: Tissue Function with In Vivo Motions
    David Butler; Fiscal Year: 2007
    ..These technologies will serve as a platform for studying injury, repair and reconstruction in the knee and other joints and to develop functional tissue engineering parameters. [unreadable] [unreadable] [unreadable]..