metered dose inhalers

Summary

Summary: A medical device used to ensure the proper amount of medication is delivered for inhalation. Usually, it is a small aerosol canister placed in a plastic holder. When the canister is pressed, a calibrated amount of drug is released.

Top Publications

  1. ncbi Fluticasone propionate hydrofluoroalkane inhalation aerosol in patients receiving inhaled corticosteroids
    William R Lumry
    AARA Research Center, Dallas, TX 75231, USA
    Ann Allergy Asthma Immunol 96:51-9. 2006
  2. ncbi Efficacy and safety of budesonide and formoterol in one pressurised metered-dose inhaler in adults and adolescents with moderate to severe asthma: a randomised clinical trial
    Michael Noonan
    Allergy Associates Research Center, Portland, Oregon 97213, USA
    Drugs 66:2235-54. 2006
  3. pmc Efficacy and tolerability of budesonide/formoterol in one hydrofluoroalkane pressurized metered-dose inhaler in patients with chronic obstructive pulmonary disease: results from a 1-year randomized controlled clinical trial
    Stephen I Rennard
    Pulmonary Critical Care, Allergy and Sleep Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 5885, USA
    Drugs 69:549-65. 2009
  4. pmc Efficacy and safety characteristics of mometasone furoate/formoterol fumarate fixed-dose combination in subjects with moderate to very severe COPD: findings from pooled analysis of two randomized, 52-week placebo-controlled trials
    Donald P Tashkin
    David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Int J Chron Obstruct Pulmon Dis 7:73-86. 2012
  5. ncbi Tiotropium 5microg via Respimat and 18microg via HandiHaler; efficacy and safety in Japanese COPD patients
    M Ichinose
    Third Department of Internal Medicine, Wakayama Medical University, Kimiidera, Wakayama, Japan
    Respir Med 104:228-36. 2010
  6. ncbi Lung function and asthma control with beclomethasone and formoterol in a single inhaler
    G Huchon
    Service de Pneumologie et Reanimation, hôpital de l Hôtel dieu, Paris, 1 Place du Parvis Notre Dame, 75181, Cedex 04, France
    Respir Med 103:41-9. 2009
  7. ncbi Regional lung deposition and bronchodilator response as a function of beta2-agonist particle size
    Omar S Usmani
    Department of Thoracic Medicine, Airways Disease Section, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK
    Am J Respir Crit Care Med 172:1497-504. 2005
  8. ncbi The efficacy of tiotropium administered via Respimat Soft Mist Inhaler or HandiHaler in COPD patients
    J A Van Noord
    Department of Respiratory Diseases, Atrium Medisch Centrum, Heerlen, The Netherlands
    Respir Med 103:22-9. 2009
  9. ncbi Metered dose inhalers: a need for dose counters
    Shaun Holt
    P3 Research, Wellington, New Zealand
    Respirology 10:105-6. 2005
  10. ncbi Inhaler device selection: special considerations in elderly patients with chronic obstructive pulmonary disease
    Robert Barrons
    Wingate University School of Pharmacy, NC 28174, USA
    Am J Health Syst Pharm 68:1221-32. 2011

Detail Information

Publications206 found, 100 shown here

  1. ncbi Fluticasone propionate hydrofluoroalkane inhalation aerosol in patients receiving inhaled corticosteroids
    William R Lumry
    AARA Research Center, Dallas, TX 75231, USA
    Ann Allergy Asthma Immunol 96:51-9. 2006
    ..Therefore, some metered-dose inhaler products are being reformulated with "ozone-friendly" hydrofluoroalkane propellants...
  2. ncbi Efficacy and safety of budesonide and formoterol in one pressurised metered-dose inhaler in adults and adolescents with moderate to severe asthma: a randomised clinical trial
    Michael Noonan
    Allergy Associates Research Center, Portland, Oregon 97213, USA
    Drugs 66:2235-54. 2006
    ..The efficacy and safety of the combination of budesonide and formoterol delivered via dry powder inhaler (DPI) is well documented...
  3. pmc Efficacy and tolerability of budesonide/formoterol in one hydrofluoroalkane pressurized metered-dose inhaler in patients with chronic obstructive pulmonary disease: results from a 1-year randomized controlled clinical trial
    Stephen I Rennard
    Pulmonary Critical Care, Allergy and Sleep Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 5885, USA
    Drugs 69:549-65. 2009
    ....
  4. pmc Efficacy and safety characteristics of mometasone furoate/formoterol fumarate fixed-dose combination in subjects with moderate to very severe COPD: findings from pooled analysis of two randomized, 52-week placebo-controlled trials
    Donald P Tashkin
    David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Int J Chron Obstruct Pulmon Dis 7:73-86. 2012
    ....
  5. ncbi Tiotropium 5microg via Respimat and 18microg via HandiHaler; efficacy and safety in Japanese COPD patients
    M Ichinose
    Third Department of Internal Medicine, Wakayama Medical University, Kimiidera, Wakayama, Japan
    Respir Med 104:228-36. 2010
    ..To compare the efficacy and safety of tiotropium inhaled via Respimat Soft Mist Inhaler, a multidose propellant-free inhaler and HandiHaler, a single-dose dry powder inhaler, in a phase 2 study of Japanese COPD patients...
  6. ncbi Lung function and asthma control with beclomethasone and formoterol in a single inhaler
    G Huchon
    Service de Pneumologie et Reanimation, hôpital de l Hôtel dieu, Paris, 1 Place du Parvis Notre Dame, 75181, Cedex 04, France
    Respir Med 103:41-9. 2009
    ....
  7. ncbi Regional lung deposition and bronchodilator response as a function of beta2-agonist particle size
    Omar S Usmani
    Department of Thoracic Medicine, Airways Disease Section, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK
    Am J Respir Crit Care Med 172:1497-504. 2005
    ..Aerosol particle size influences the extent, distribution, and site of inhaled drug deposition within the airways...
  8. ncbi The efficacy of tiotropium administered via Respimat Soft Mist Inhaler or HandiHaler in COPD patients
    J A Van Noord
    Department of Respiratory Diseases, Atrium Medisch Centrum, Heerlen, The Netherlands
    Respir Med 103:22-9. 2009
    ..The Respimat Soft Mist Inhaler (SMI), a novel, propellant-free inhaler, has been developed and proposed as an alternative delivery device for use with tiotropium...
  9. ncbi Metered dose inhalers: a need for dose counters
    Shaun Holt
    P3 Research, Wellington, New Zealand
    Respirology 10:105-6. 2005
    ..This study investigated the ability of patients to assess when a metered dose inhaler (MDI) is empty...
  10. ncbi Inhaler device selection: special considerations in elderly patients with chronic obstructive pulmonary disease
    Robert Barrons
    Wingate University School of Pharmacy, NC 28174, USA
    Am J Health Syst Pharm 68:1221-32. 2011
    ..Special considerations in the selection of medication inhaler devices for elderly patients with chronic obstructive pulmonary disease (COPD) in the ambulatory care setting are reviewed...
  11. ncbi Real-world assessment of a metered-dose inhaler with integrated dose counter
    Richard L Wasserman
    Pediatric Allergy Immunology Associates, PA, Dallas, Texas, USA
    Allergy Asthma Proc 27:486-92. 2006
    Currently available metered dose inhalers (MDIs) do not track the remaining number of doses, indicating the need for a device that accurately monitors medication use...
  12. ncbi Beclomethasone/formoterol in the management of COPD: a randomised controlled trial
    P M A Calverley
    Pulmonary and Rehabilitation Research Group, Dept of Medicine, Clinical Sciences, University Hospital Aintree, Longmoor Lane, Liverpool, United Kingdom
    Respir Med 104:1858-68. 2010
    ..To evaluate the effect of beclomethasone/formoterol versus budesonide/formoterol (non-inferiority) and versus formoterol (superiority) in patients with severe stable chronic obstructive pulmonary disease (COPD)...
  13. pmc Effects of mometasone furoate/formoterol fumarate fixed-dose combination formulation on chronic obstructive pulmonary disease (COPD): results from a 52-week Phase III trial in subjects with moderate-to-very severe COPD
    Dennis E Doherty
    Division of Pulmonary, Critical Care, and Sleep Medicine, University of Kentucky, Lexington, KY 40536, USA
    Int J Chron Obstruct Pulmon Dis 7:57-71. 2012
    ....
  14. pmc Lung deposition of BDP/formoterol HFA pMDI in healthy volunteers, asthmatic, and COPD patients
    Wilfried De Backer
    University Hospital Antwerp, Edegem, Belgium
    J Aerosol Med Pulm Drug Deliv 23:137-48. 2010
    ....
  15. ncbi Beclomethasone/formoterol versus budesonide/formoterol combination therapy in asthma
    A Papi
    Research Centre on Asthma and COPD, University of Ferrara, Italy
    Eur Respir J 29:682-9. 2007
    ....
  16. pmc Higher lung deposition with Respimat Soft Mist inhaler than HFA-MDI in COPD patients with poor technique
    Peter Brand
    RWTH, Aachen, Germany
    Int J Chron Obstruct Pulmon Dis 3:763-70. 2008
    ..Teaching patients to hold their breath as well as to inhale slowly and deeply increased further lung deposition using Respimat SMI...
  17. ncbi Inhalatory therapy training: a priority challenge for the physician
    Andrea S Melani
    Respiratory Physiopathology and Rehabilitation, Cardiothoracic Department, Polyclinic Le Scotte, Azienda Ospedaliera Universitaria Senese, Siena, Italy
    Acta Biomed 78:233-45. 2007
    ..Traditional press-and-breathe Metered Dose Inhalers (pMDIs) have recently improved their ecological appeal, can be used in every clinical and environmental ..
  18. ncbi Efficacy and safety of budesonide and formoterol in one pressurized metered-dose inhaler in patients with moderate to very severe chronic obstructive pulmonary disease: results of a 6-month randomized clinical trial
    Donald P Tashkin
    Division of Pulmonary and Critical Care Medicine, University of California, Los Angeles, California, USA
    Drugs 68:1975-2000. 2008
    ..Budesonide/formoterol dry powder inhaler (DPI) has demonstrated efficacy and tolerability in patients with COPD...
  19. ncbi Dose counting and the use of pressurized metered-dose inhalers: running on empty
    Nancy Sander
    Allergy and Asthma Network Mothers of Asthmatics, Fairfax, Virginia, USA
    Ann Allergy Asthma Immunol 97:34-8. 2006
    ..The pMDI is an economic and portable medication delivery system, but the device does not indicate how much medicine remains in the canister once a patient starts using it...
  20. ncbi Influence of particle size and patient dosing technique on lung deposition of HFA-beclomethasone from a metered dose inhaler
    Chet L Leach
    3M Pharmaceuticals, St Paul, Minnesota, USA
    J Aerosol Med 18:379-85. 2005
    ..However patients with poor technique still received a large lung dose of BDP (i.e., >or=37%) compared with lung deposition values of 4-7% for CFC-BDP MDIs previously published and confirmed in this study...
  21. pmc Patient preferences for inhaler devices in chronic obstructive pulmonary disease: experience with Respimat Soft Mist inhaler
    Richard Hodder
    Divisions of Pulmonary and Critical Care, University of Ottawa, Ottawa, Ontario, Canada
    Int J Chron Obstruct Pulmon Dis 4:381-90. 2009
    ....
  22. pmc Estimating the number of droplets and drug particles emitted from MDIs
    Stephen W Stein
    Early Pharmaceutics and Technology Department, 3M Drug Delivery Systems, 3M Center Building 260 3A 05, St Paul, Minnesota, USA
    AAPS PharmSciTech 9:112-5. 2008
    ..However, for suspension MDI formulations many of the droplets do not contain any micronized drug particles and the number of drug particles is much lower than the number of atomized droplets...
  23. ncbi The reliability and patient acceptability of the SmartTrack device: a new electronic monitor and reminder device for metered dose inhalers
    Juliet M Foster
    Department of Clinical Management, Woolcock Institute of Medical Research, University of Sydney, Missenden Road, Sydney, NSW 2050, Australia
    J Asthma 49:657-62. 2012
    ..The SmartTrack (ST) is a new adherence monitoring device for pressurized metered-dose inhalers (pMDI), with remote upload and ringtone reminder capabilities. Our aim was to assess its reliability and patient acceptability...
  24. ncbi The effects of polyvinyl alcohol on the in vitro stability and delivery of spray-dried protein particles from surfactant-free HFA 134a-based pressurised metered dose inhalers
    Yong Hong Liao
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Xi Bei Wang, Hai Dian District, Beijing 100094, PR China
    Int J Pharm 304:29-39. 2005
    ..the physical stability of spray-dried proteins within surfactant-free hydrofluoroalkane (HFA) pressurised metered dose inhalers (pMDIs) during prolonged storage...
  25. ncbi Principles of metered-dose inhaler design
    Stephen P Newman
    Pharmaceutical Profiles Ltd, Nottingham, United Kingdom
    Respir Care 50:1177-90. 2005
    ..Modern pMDI devices, which contain non-ozone-depleting propellants, should allow inhalation therapy via pMDI to extend well into the 21st century for a variety of treatment indications...
  26. ncbi Long-term safety and asthma control with budesonide/formoterol versus budesonide pressurized metered-dose inhaler in asthma patients
    Stephen P Peters
    Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Allergy Asthma Proc 29:499-516. 2008
    ..Improvements in asthma control were shown with both doses of budesonide/formoterol versus budesonide...
  27. ncbi Electrostatic charge characteristics of aerosols produced from metered dose inhalers
    Philip Chi Lip Kwok
    Faculty of Pharmacy, University of Sydney, Sydney, NSW 2006, Australia
    J Pharm Sci 94:2789-99. 2005
    The electrostatic charge properties of aerosols produced by commercial metered dose inhalers (MDIs), including Ventolin, QVAR, Flixotide, Intal Forte, and Tilade were studied using a modified 13-stage electrical low pressure impactor (..
  28. ncbi Aiming for a moving target: challenges with impactor measurements of MDI aerosols
    Stephen W Stein
    3M Drug Delivery Systems, 3M Center Building 260 3A 05, St Paul, MN 55144 1000, United States
    Int J Pharm 355:53-61. 2008
    ..S. Pharmacopeia, 1996. Physical tests and determinations <601> aerosols, metered dose inhalers, and dry powders. Pharmacopeial Forum 22, pp...
  29. ncbi Lung deposition of formoterol HFA (Atimos/Forair) in healthy volunteers, asthmatic and COPD patients
    Sabine Häussermann
    Inamed Research GmbH and Co KG, Robert Koch Allee 29, 82131 Gauting, Germany
    J Aerosol Med 20:331-41. 2007
    ..8 microm) of the HFA-Formoterol-Formulation and the slow inhalation (30 L/min flow) used in this study. It can be concluded, that with this modern HFA drug formulation, the deposition is high, even in obstructed lungs...
  30. ncbi Not all asthma inhalers are the same: factors to consider when prescribing an inhaler
    Henry Chrystyn
    Department of Pharmacy, University of Huddersfield, School of Applied Sciences, Queensgate, Huddersfield, West Yorkshire, UK
    Prim Care Respir J 18:243-9. 2009
    ..This review should provide prescribers with an update to help them appreciate the differences between inhalers thereby optimising each patient's inhaled treatment...
  31. ncbi Patient satisfaction with a pressurized metered-dose inhaler with an integrated dose counter containing a fixed-dose mometasone furoate/formoterol combination
    Craig LaForce
    Department of Pediatrics, University of North Carolina School of Medicine, North Carolina Clinical Research, Raleigh, NC, USA
    J Asthma 48:625-31. 2011
    ....
  32. ncbi Reverse aqueous emulsions and microemulsions in HFA227 propellant stabilized by non-ionic ethoxylated amphiphiles
    Udayan Chokshi
    Department of Chemical Engineering and Materials Science, Wayne State University, 5050 Anthony Wayne Dr, Detroit, MI 48202, United States
    Int J Pharm 369:176-84. 2009
    ..Such dispersions are potential candidates for the delivery of small polar solutes and larger therapeutic biomolecules to and through the lungs in the form of pMDI formulations, and in other medical sprays...
  33. ncbi Forced degradation study to develop and validate stability-indicating RP-LC method for the determination of ciclesonide in bulk drug and metered dose inhalers
    Ehab F Elkady
    Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El Aini St, Cairo 11562, Egypt
    Talanta 87:222-9. 2011
    ..The proposed method was successfully applied to the determination of ciclesonide in bulk and in its pharmaceutical preparation...
  34. ncbi The influence of formulation variables on the performance of alternative propellant-driven metered dose inhalers
    Hugh D C Smyth
    1311 Kerr Hall, CB 7360, Division of Drug Delivery and Disposition, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Adv Drug Deliv Rev 55:807-28. 2003
    ..This review outlines research efforts that have focused on the formulation of propellant-driven metered dose inhalers using alternative propellants...
  35. pmc Clinical effectiveness of the Respimat inhaler device in managing chronic obstructive pulmonary disease: evidence when compared with other handheld inhaler devices
    Felix S F Ram
    School of Health and Social Services, Massey University, Auckland, New Zealand
    Int J Chron Obstruct Pulmon Dis 6:129-39. 2011
    ..This study was undertaken to determine the clinical effectiveness of the Respimat handheld inhaler device compared with other handheld inhaler devices for the delivery of medication in stable COPD...
  36. ncbi Comparative in vitro evaluation of four corticosteroid metered dose inhalers: Consistency of delivered dose and particle size distribution
    Tjalling W de Vries
    Department of Paediatrics, Medical Centre Leeuwarden, P O Box 888, 8901 BR Leeuwarden, The Netherlands
    Respir Med 103:1167-73. 2009
    Recent developments concerning pressurized metered dose inhalers (pMDIs) with inhaled corticosteroids (ICS) are the introduction of ciclesonide and the replacement of propellants...
  37. ncbi Efficacy of budesonide/formoterol pressurized metered-dose inhaler versus budesonide pressurized metered-dose inhaler alone in Hispanic adults and adolescents with asthma: a randomized, controlled trial
    James Zangrilli
    AstraZeneca LP, Wilmington, Delaware, USA
    Ann Allergy Asthma Immunol 107:258-65.e2. 2011
    ..Few clinical trials in asthma have focused on Hispanic populations...
  38. ncbi Spray pattern analysis for metered dose inhalers I: Orifice size, particle size, and droplet motion correlations
    H Smyth
    School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, USA
    Drug Dev Ind Pharm 32:1033-41. 2006
    ..Developing an understanding of these processes may provide a basis for developing spray pattern tests with relevance to product performance...
  39. ncbi Budesonide/formoterol pressurized metered-dose inhaler versus budesonide: a randomized controlled trial in black patients with asthma
    Sheldon L Spector
    California Allergy and Asthma Medical Group, Los Angeles, CA 90025, USA
    J Asthma 49:70-7. 2012
    ..The efficacy and safety of budesonide/formoterol (BUD/FM) pressurized metered-dose inhaler (pMDI) versus budesonide dry powder inhaler (BUD DPI) were evaluated in adolescent and adult black asthma patients...
  40. ncbi Investigation into the influence of polymeric stabilizing excipients on inter-particulate forces in pressurised metered dose inhalers
    D Traini
    Pharmaceutical Surface Science Research Group, Department of Pharmacy, University of Bath, Bath BA2 7AY, United Kingdom
    Int J Pharm 320:58-63. 2006
    ..In this context, the use of the colloid probe AFM technique has provided a quantitative insight into the interactions of these complex systems and may be an invaluable asset during the early phase of formulation product development...
  41. ncbi Spray pattern analysis for metered dose inhalers: effect of actuator design
    Hugh Smyth
    College of Pharmacy, University of New Mexico, Albuquerque, NM 87131, USA
    Pharm Res 23:1591-6. 2006
    ..This study was conducted to identify the device factors influencing spray pattern and particle size to gain a more complete understanding of spray plume measurements...
  42. ncbi The CFC to HFA transition and its impact on pulmonary drug development
    Chet L Leach
    Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
    Respir Care 50:1201-8. 2005
    ..The transition from CFCs also spurred novel new drug-delivery technologies, improved dry powder inhalers, and highly dispersible engineered powders...
  43. ncbi Device selection and outcomes of aerosol therapy: Evidence-based guidelines: American College of Chest Physicians/American College of Asthma, Allergy, and Immunology
    Myrna B Dolovich
    Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada
    Chest 127:335-71. 2005
    ..There are advantages and disadvantages associated with each device category. Evidence-based guidelines for the selection of the appropriate aerosol delivery device in specific clinical settings are needed...
  44. ncbi Comparison of the aerosol velocity and spray duration of Respimat Soft Mist inhaler and pressurized metered dose inhalers
    Dieter Hochrainer
    Boehringer Ingelheim Pharma GmbH and Co KG, Ingelheim, Germany
    J Aerosol Med 18:273-82. 2005
    ..generation, propellant-free inhaler that delivers drug to the lung much more efficiently than pressurised metered dose inhalers (pMDIs)...
  45. ncbi Beclomethasone/formoterol vs fluticasone/salmeterol inhaled combination in moderate to severe asthma
    A Papi
    Research Centre on Asthma and COPD, University of Ferrara, Ferrara, Italy
    Allergy 62:1182-8. 2007
    ..The present study was designed to compare a new fixed combination of extrafine beclomethasone and formoterol, with the fixed combination fluticasone and salmeterol...
  46. ncbi Fluticasone propionate/salmeterol hydrofluoroalkane via metered-dose inhaler with integrated dose counter: Performance and patient satisfaction
    K Sheth
    Lafayette Allergy and Asthma Clinic, Lafayette, IN 47905, USA
    Int J Clin Pract 60:1218-24. 2006
    ..This integrated MDI counter may help patients maintain better disease control by enabling them to accurately track their medication supply...
  47. ncbi Inadequate skill of healthcare professionals in using asthma inhalation devices
    Timothy H Self
    University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Asthma 44:593-8. 2007
    ..Practical solutions to this problem are needed to enhance the care of asthma patients...
  48. ncbi Extra-fine particles improve lung delivery of inhaled steroids in infants: a study in an upper airway model
    Hettie M Janssens
    Department of Pediatrics, Division of Respiratory Medicine, Sophia Childrens Hospital Erasmus Medical Center, Rotterdam, The Netherlands
    Chest 123:2083-8. 2003
    ..Aim: To compare the dose delivered to the lungs of HFA-BDP and CFC-BDP at different breathing patterns using an upper airway model of an infant...
  49. pmc Long-term safety of mometasone furoate/formoterol combination for treatment of patients with persistent asthma
    Jorge F Maspero
    Fundacion CIDEA, Allergy Respiratory Research, Buenos Aires, Argentina
    J Asthma 47:1106-15. 2010
    ..This study was conducted to evaluate the long-term safety of mometasone furoate/formoterol (MF/F) administered through metered-dose inhaler (MDI) in patients with persistent asthma previously on medium- to high-dose ICS...
  50. pmc Health outcomes following treatment for six months with once daily tiotropium compared with twice daily salmeterol in patients with COPD
    V Brusasco
    Facolta di Medicina e Chirurgia, Universita di Genova, Genova, Italy
    Thorax 58:399-404. 2003
    ..A study was undertaken to record exacerbations and health resource use in patients with COPD during 6 months of treatment with tiotropium, salmeterol, or matching placebos...
  51. ncbi Bronchodilation of formoterol administered with budesonide: device and formulation effects
    Christopher J Miller
    AstraZeneca, 1800 Concord Pike, Wilmington, DE 19850, United States
    Contemp Clin Trials 29:114-24. 2008
    ....
  52. ncbi How do patients determine that their metered-dose inhaler is empty?
    Bruce K Rubin
    Department of Pediatrics, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Chest 126:1134-7. 2004
    ..To evaluate how patients determined that pressurized metered-dose inhaler (pMDI) canisters were empty and to measure pMDI depletion under different circumstances in the laboratory...
  53. ncbi Inhalation technique and variables associated with misuse of conventional metered-dose inhalers and newer dry powder inhalers in experienced adults
    Andrea S Melani
    Fisiopatologia e Riabilitazione Respiratoria, Policlinico Le Scotte, Azienda Ospedaliera Senese, Siena, Italy
    Ann Allergy Asthma Immunol 93:439-46. 2004
    ..Pressurized metered-dose inhalers (pMDIs) are often poorly used, but little information is available concerning use of the newer dry powder inhalers (DPIs)...
  54. ncbi Pharmacokinetics of budesonide and formoterol administered via 1 pressurized metered-dose inhaler in patients with asthma and COPD
    Ann Tronde
    AstraZeneca R and D Lund, SE 221 87, Lund, Sweden
    J Clin Pharmacol 48:1300-8. 2008
    ..In conclusion, systemic exposure generally is similar or lower with budesonide/formoterol pMDI versus combination therapy via separate DPIs or monotherapy and comparable between asthma and COPD patients...
  55. ncbi The inhalation of drugs: advantages and problems
    Joseph L Rau
    Department of Cardiopulmonary Care Sciences, Georgia State University, Atlanta, USA
    Respir Care 50:367-82. 2005
    ..Potential improvements in aerosol delivery include better standardization of function and patient use, greater reliability, and reduction of drug loss...
  56. ncbi Improvement of asthma control with a breath-actuated pressurised metred dose inhaler (BAI): a prescribing claims study of 5556 patients using a traditional pressurised metred dose inhaler (MDI) or a breath-actuated device
    D Price
    Department of General Practice and Primary Care, University of Aberdeen, Foresterhill Health Centre, Aberdeen, AB25 2AY, UK
    Respir Med 97:12-9. 2003
    ..Breath actuated inhalers (BAIs) are reported to be easier to use than metered dose inhalers (MDIs)...
  57. pmc Assessment of different methods of inhalation from salbutamol metered dose inhalers by urinary drug excretion and methacholine challenge
    Heather S Tomlinson
    School of Pharmacy, University of Bradford, Bradford, BD7 1DP, UK
    Br J Clin Pharmacol 60:605-10. 2005
    Methods to determine the lung delivery of inhaled bronchodilators from metered dose inhalers include urinary drug excretion 30 min post inhalation and methacholine challenge (PD20)...
  58. ncbi Problems with inhaler use: a call for improved clinician and patient education
    James B Fink
    Aerogen, Mountain View, California 94943, USA
    Respir Care 50:1360-74; discussion 1374-5. 2005
    ..Problems with inhaler use, the cost of inhalers, and myths associated with inhalers are reviewed, with recommendations for strategies and techniques to better educate patients in inhaler use...
  59. ncbi Efficacy and safety of ipratropium bromide plus fenoterol inhaled via Respimat Soft Mist Inhaler vs. a conventional metered dose inhaler plus spacer in children with asthma
    Andrea von Berg
    Marien Hospital GmbH, Wesel, Germany
    Pediatr Pulmonol 37:264-72. 2004
    ..Use of Respimat SMI thus enables a 2-4-fold reduction in the nominal dose of IB/FEN, and obviates the need for a spacer...
  60. pmc A dose-ranging study of tiotropium delivered via Respimat Soft Mist Inhaler or HandiHaler in COPD patients
    Denis Caillaud
    CHU Clermont Ferrand, Pulmonary Department, Hopital G Montpied, Clermont Ferrand, France
    Int J Chron Obstruct Pulmon Dis 2:559-65. 2007
    ..Tiotropium 5 and 10 microg Respimat improve lung function in COPD patients and appear to be comparable with tiotropium 18 microg HandiHaler...
  61. ncbi Inhaled beclometasone dipropionate/formoterol extra-fine fixed combination in the treatment of asthma: evidence and future perspectives
    Leonardo Michele Fabbri
    Department of Respiratory Diseases, University of Modena and Reggio Emilia, Via del Pozzo 71, I 41100 Modena, Italy
    Expert Opin Pharmacother 9:479-90. 2008
    ..Combinations of a long-acting beta(2)-agonist (LABA) and an inhaled corticosteroid (ICS) are effective and safe options in asthma management...
  62. ncbi Inhaled mometasone furoate reduces oral prednisone usage and improves lung function in severe persistent asthma
    Jill P Karpel
    North Shore University Hospital, New Hyde Park, NY 11040, USA
    Respir Med 101:628-37. 2007
    ..The reduction of oral prednisone use by mometasone furoate (MF) delivered by HFA-227 metered dose inhaler (MDI) was examined in oral corticosteroid (OCS)-dependent patients with severe persistent asthma...
  63. ncbi Budesonide/formoterol combination therapy as both maintenance and reliever medication in asthma
    Paul M O'Byrne
    Firestone Institute for Respiratory Health, St Joseph s Hospital, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 171:129-36. 2005
    ..001), reduced severe exacerbation rate, and improved symptoms, awakenings, and lung function compared with both fixed dosing regimens...
  64. ncbi Incorrect application technique of metered dose inhalers by internal medicine residents: impact of exposure to a practical situation
    Rafael Stelmach
    Pulmonary Division, Heart Institute InCor, University of Sao Paulo Medical School, Brazil
    J Asthma 44:765-8. 2007
    We evaluated residents regarding maintenance treatment of asthma and the technique for using metered dose inhalers. Methods...
  65. ncbi Propellant-driven metered-dose inhalers for pulmonary drug delivery
    Hugh D C Smyth
    University of North Carolina at Chapel Hill, School of Pharmacy, NC 27599, USA
    Expert Opin Drug Deliv 2:53-74. 2005
    ..The ability to succeed in these areas will be largely determined by the willingness to invest in fundamental research of pMDI technologies...
  66. ncbi Formoterol delivered via the dry powder Aerolizer inhaler versus albuterol MDI and placebo in mild-to-moderate asthma: a randomized, double-blind, double-dummy trial
    W Pleskow
    Radiant Research, Encinitas, California, USA
    J Asthma 40:505-14. 2003
    ..Overall, compared with albuterol, both formoterol doses produced superior bronchodilation. Formoterol and albuterol were safe and well-tolerated...
  67. ncbi Comparable long-term safety and efficacy of a novel budesonide/formoterol pressurized metered-dose inhaler versus budesonide/formoterol Turbuhaler in adolescents and adults with asthma
    Alyn H Morice
    Respiratory Medicine, Academic Medicine, University of Hull, Castle Hill Hospital, Castle Road, Cottingham, East Yorkshire HU16 5JQ, UK
    Pulm Pharmacol Ther 21:32-9. 2008
    ..The novel HFA pMDI formulation of budesonide/formoterol is an equally well tolerated and effective treatment for adults and adolescents with asthma as the budesonide/formoterol DPI...
  68. ncbi Sub-micrometer particle production by pressurized metered dose inhalers
    Mark Crampton
    Division of Environmental Health and Risk Management, University of Birmingham, Birmingham B15 2TT, United Kingdom
    J Aerosol Med 17:33-42. 2004
    ..Andersen impactors and liquid impingers have been used for the sizing of particles produced by pressurized metered dose inhalers (pMDIs)...
  69. ncbi Comparison of patient preference and ease of teaching inhaler technique for Pulmicort Turbuhaler versus pressurized metered-dose inhalers
    Michael J Welch
    Allergy and Asthma Medical Group and Research Center, San Diego, California 92123, USA
    J Aerosol Med 17:129-39. 2004
    ..05). Overall, patients preferred Pulmicort Turbuhaler over pMDIs and required less time to be taught how to correctly use Turbuhaler trade mark...
  70. ncbi Budesonide/formoterol pressurized metered-dose inhaler: in chronic obstructive pulmonary disease
    Katherine A Lyseng-Williamson
    Wolters Kluwer Health, Adis, Auckland, New Zealand
    Drugs 69:1459-70. 2009
    ..Its overall adverse event profile is consistent with the known tolerability profiles of formoterol and budesonide, and is generally similar to that with placebo...
  71. ncbi Deposition of corticosteroid aerosol in the human lung by Respimat Soft Mist inhaler compared to deposition by metered dose inhaler or by Turbuhaler dry powder inhaler
    Gary Pitcairn
    Pharmaceutical Profiles Ltd, Nottingham, United Kingdom
    J Aerosol Med 18:264-72. 2005
    ..The results of this study showed that Respimat SMI deposited corticosteroid more efficiently in the lungs than either of two widely used inhaler devices, Turbuhaler DPI or Becloforte pMDI...
  72. ncbi A review of the development of Respimat Soft Mist Inhaler
    R Dalby
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, 20 North Pine Street, Baltimore MD 21201 1180, USA
    Int J Pharm 283:1-9. 2004
    ..This is higher than aerosol clouds from conventional portable inhaler devices, such as pressurised metered dose inhalers (pMDIs) and dry powder inhalers (DPIs)...
  73. ncbi Combination therapy with single inhaler budesonide/formoterol compared with high dose of fluticasone propionate alone in patients with moderate persistent asthma
    Eric D Bateman
    University of Cape Town, Cape Town, South Africa
    Am J Respir Med 2:275-81. 2003
    ..The efficacy and safety of Symbicort (budesonide and formoterol in a single inhaler) were compared with those of a high dose of the commonly used corticosteroid fluticasone propionate in patients with moderate persistent asthma...
  74. ncbi Results of a physician and respiratory therapist collaborative effort to improve long-term metered-dose inhaler technique in a pediatric asthma clinic
    Beena A Minai
    Department of Pediatrics, MetroHealth Medical Center, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44109, USA
    Respir Care 49:600-5. 2004
    ..We operate an inner-city Pediatric Asthma Compliance and Technique (PACT) clinic in which physicians and respiratory therapists collaborate to improve metered-dose inhaler (MDI) technique and outcomes among asthmatic children...
  75. ncbi Aerodynamic sizing of metered dose inhalers: an evaluation of the Andersen and Next Generation pharmaceutical impactors and their USP methods
    Akihiko Kamiya
    Department of Pharmaceutics, School of Pharmacy, Virginia Commonwealth University, 410 N 12th Street, P O Box 980533, Richmond, Virginia 23298, USA
    J Pharm Sci 93:1828-37. 2004
    ..However, small differences in PSD profiles still existed to support NGI's design claims for reduced "overlap" in its stage collection efficiency curves...
  76. pmc Therapeutic comparison of a new budesonide/formoterol pMDI with budesonide pMDI and budesonide/formoterol DPI in asthma
    A H Morice
    Academic Medicine, University of Hull, East Yorkshire, UK
    Int J Clin Pract 61:1874-83. 2007
    ....
  77. ncbi Low incidence of paradoxical bronchoconstriction with bronchodilator drugs administered by Respimat Soft Mist inhaler: results of phase II single-dose crossover studies
    D Koehler
    Krankenhaus Kloster Grafschaft, Schmallenberg, Germany
    Respiration 71:469-76. 2004
    ....
  78. ncbi Comparing COPD treatment: nebulizer, metered dose inhaler, and concomitant therapy
    Donald P Tashkin
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, Calif 90095 1690, USA
    Am J Med 120:435-41. 2007
    ..and ipratropium for treating chronic obstructive pulmonary disease (COPD) can use either nebulizers or metered dose inhalers. This study compared the 2 methods of delivering medication and the concomitant use of both nebulizer and ..
  79. ncbi Symbicort: a pharmacoeconomic review
    David Mg Halpin
    J Med Econ 11:345-62. 2008
    ..In asthma, Symbicort can be used as fixed or adjustable dose maintenance therapy as well as for both maintenance and reliever therapy (SMART)...
  80. ncbi Fenoterol delivery by Respimat soft mist inhaler versus CFC metered dose inhaler: cumulative dose-response study in asthma patients
    Walter Vincken
    Respiratory Division, Academic Hospital, University of Brussels, Brussels, Belgium
    J Asthma 40:721-30. 2003
    ..The aim of this study was to evaluate the safety and establish the equipotent dose of fenoterol delivered by RMT SMI vs. a conventional MDI...
  81. ncbi Metered-dose inhalers and dry powder inhalers in aerosol therapy
    Dean R Hess
    Department of Respiratory Care, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts 02114, USA
    Respir Care 50:1376-83. 2005
    ..The proceedings of this conference provide the current state of the art of metered-dose inhalers and dry powder inhalers...
  82. pmc A randomised, double-blind, placebo-controlled study to evaluate the role of formoterol in the management of acute asthma
    Katayoon Najafizadeh
    Department of Pulmonary Medicine, National Research Institute of Tuberculosis and Lung Diseases, Tehran, Iran
    Emerg Med J 24:317-21. 2007
    ..To evaluate the efficacy and tolerability of formoterol delivered by Aerolizer in the emergency department...
  83. ncbi The correlation of urinary levels of albuterol and its metabolites isomers following inhalation from a dry powder inhaler and in vitro particle size characterisation
    Teerapol Srichana
    Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkla, 90112, Thailand
    Pulm Pharmacol Ther 20:36-45. 2007
    ..0-4.5. In summary, the urinary level of albuterol following in vivo inhalation was found to correlate with in vitro deposition data from the dry powder inhaler...
  84. ncbi The conversion to metered-dose inhaler with valved holding chamber to administer inhaled albuterol: a pediatric hospital experience
    John W Salyer
    Department of Respiratory Care, Children s Hospital and Regional Medical Center, 4800 Sandpoint Way NE, Seattle WA 98105, USA
    Respir Care 53:338-45. 2008
    ..At Seattle Children's Hospital and Regional Medical Center we sought to implement the conversion from SVN to MDI-delivered albuterol in nonintubated patients receiving intermittent treatments...
  85. ncbi Efficacy and safety of fluticasone propionate hydrofluoroalkane inhalation aerosol in pre-school-age children with asthma: a randomized, double-blind, placebo-controlled study
    Paul Y Qaqundah
    Pediatric Medical Care Group, Inc, Huntington Beach, CA, USA
    J Pediatr 149:663-670. 2006
    ..To evaluate the efficacy and tolerability of fluticasone propionate (FP) hydrofluoroalkane (HFA) in children age 1 to < 4 years with asthma...
  86. ncbi Fluticasone propionate HFA-134a pressurized metered-dose inhaler in adolescents and adults with moderate to severe asthma
    Jacob L Pinnas
    University of Arizona School of Medicine, Tucson, Arizona, USA
    J Asthma 42:865-71. 2005
    ..The incidence of adverse events and 24-hour urine cortisol excretion rates were similar between active treatments and placebo...
  87. ncbi The role of the MDI and DPI in pediatric patients: "Children are not just miniature adults"
    Richard C Ahrens
    Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Respir Care 50:1323-8; discussion 1328-30. 2005
    ..It is likely that the risk of adverse effects on growth are different for each of the many possible MDI/valved-holding-chamber combinations...
  88. ncbi [Bronchodilators in acute asthma: metered dose inhalers or wet nebulizations?]
    Dora M Lombardi
    Hospital Municipal de Rehabilitación Respiratoria María Ferrer, Finochietto 849, 1272 Buenos Aires, Argentina
    Medicina (B Aires) 66:563-8. 2006
    ..To improve treatment goals, we switched the method of bronchodilator delivery to metered dose inhalers (MDI) in 2003...
  89. pmc Speed of onset of bronchodilator response to salbutamol inhaled via different devices in asthmatics: a bioassay based on functional antagonism
    Federico Lavorini
    Dipartimento di Area Critica Medico Chirurgica, Unità Funzionale di Medicina Respiratoria, Universita degli Studi di Firenze, Italia
    Br J Clin Pharmacol 62:403-11. 2006
    ....
  90. ncbi Generating monodisperse pharmacological aerosols using the spinning-top aerosol generator
    Martyn F Biddiscombe
    Nuclear Medicine, Royal Brompton Hospital, and National Heart and Lung Institute, Imperial College London, London, United Kingdom
    J Aerosol Med 19:245-53. 2006
    ..The aerosols generated by the STAG can allow investigators to study the scientific principles of inhaled drug deposition and lung physiology for a range of therapeutic agents...
  91. ncbi Evaluation of levalbuterol metered dose inhaler in pediatric patients with asthma: a double-blind, randomized, placebo- and active-controlled trial
    William E Berger
    Allergy and Asthma Associates of Southern California, Mission Viejo, CA, USA
    Curr Med Res Opin 22:1217-26. 2006
    ..To evaluate the efficacy and safety of levalbuterol metered dose inhaler (MDI) in children aged 4-11 years (n = 173)...
  92. ncbi Management of acute asthma in children using metered dose inhaler and small volume nebulizer
    Syed Waseem Jamalvi
    Department of Pediatrics, Jinnah Medical and Dental College, Karachi
    J Pak Med Assoc 56:595-9. 2006
    ..To determine whether the administration of beta2-agonist by Metered Dose inhaler (MDI) with accessory device (AD) is a as effective as the administration of beta2-agonist by small volume nebulizers (SVN) for the treatment of acute asthma...
  93. ncbi The correlation between asthma control and health status: the GOAL study
    E D Bateman
    University of Cape Town, Cape Town, South Africa
    Eur Respir J 29:56-62. 2007
    ..The difference in Asthma Quality of Life Questionnaire scores between total control and well-controlled confirms that patients distinguish even between these high levels of control...
  94. ncbi Withdrawal of albuterol inhalers containing chlorofluorocarbon propellants
    Leslie Hendeles
    College of Pharmacy and the Pediatric Pulmonary Division, University of Florida, Gainesville, FL 32610 0486, USA
    N Engl J Med 356:1344-51. 2007
  95. ncbi Efficacy and tolerability of fluticasone propionate/salmeterol administered twice daily via hydrofluoroalkane 134a metered-dose inhaler in adolescent and adult patients with persistent asthma: a randomized, double-blind, placebo-controlled, 12-week study
    Robert A Nathan
    Asthma and Allergy Associates, Colorado Springs, Colorado 80907, USA
    Clin Ther 28:73-85. 2006
    ....
  96. ncbi Asthmatics: too drunk to drive? The time curve of exhaled ethanol levels after use of Salamol in normal subjects
    Oisin O'Connell
    Department of Respiratory Medicine, Christchurch Hospital, Christchurch
    N Z Med J 119:U2282. 2006
    ....
  97. ncbi Pressurised metered-dose inhalers (MDIs) versus dry powder inhalers devices (DPIs) to rapid-acting inhaled b2-agonists for asthma in children
    J M Negro Alvarez
    Sección de Alergología H U Virgen de la Arrixaca Murcia Spain
    Allergol Immunopathol (Madr) 30:245-9. 2002
    ..To compare the clinical effectiveness of pressurized metered-dose inhalers (MDIs) with that of dry powder inhalers (DPIs) in delivering short-acting b2-agonists in children with asthma...
  98. ncbi Comparing clinical features of the nebulizer, metered-dose inhaler, and dry powder inhaler
    David E Geller
    The Nemours Children s Clinic, Orlando, Florida 32806, USA
    Respir Care 50:1313-21; discussion 1321-2. 2005
    ..Clinicians should also have a rudimentary understanding of aerosol principles in order to be able to teach appropriate use of aerosol devices to their patients...
  99. pmc Dose-response to salbutamol via a novel palm sized nebuliser (Aerodose Inhaler), conventional nebuliser (Pari LC Plus) and metered dose inhaler (Ventolin Evohaler) in moderate to severe asthmatics
    Brian J Lipworth
    Department of Medicine and Therapeutics, Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee Scotland, DD1 9SY, UK
    Br J Clin Pharmacol 59:5-13. 2005
    ..Mountain View, USA) vs Pari LC Plus jet nebulizer (Pari LC Plus; Pari GmbH, Starnberg, Germany) and Ventolin Evohaler HFA pMDI (Evohaler; Allen & Hanburys [GlaxoSmithkline], Uxbridge, UK)...
  100. ncbi Effect of mouthpiece washing on aerosol performance of CFC-free Ventolin
    Nora Y K Chew
    Faculty of Pharmacy, University of Sydney, Australia
    J Asthma 41:721-7. 2004
    ..However, in view of the steep bronchodilator dose-response curve for salbutamol, further studies are needed to determine whether such device care is clinically necessary...
  101. ncbi Agreement between two methods for assessing bioequivalence of inhaled salbutamol
    Federico Lavorini
    Dipartimento di Area Critica Medico Chirurgica, Unità Funzionale di Medicina Respiratoria, Universita degli Studi di Firenze, Viale G B Morgagni 85 50134, Firenze, Italy
    Pulm Pharmacol Ther 21:380-4. 2008
    ..The pMDI+ Volumatic is twice as efficient as the Diskus in lung delivery of salbutamol in asthma patients...

Research Grants35

  1. Comprehensive evaluation of formulation effects on metered dose inhaler performan
    JAY HOLT; Fiscal Year: 2013
    Summary Metered dose inhalers represent a large proportion of inhaled products used in the treatment and prevention of asthma and chronic obstructive lung disease...
  2. LUNG DRUG DELIVERY WITH CARBON DIOXIDE AEROSOL INHALERS
    Brian Hansen; Fiscal Year: 2009
    ....
  3. Aerosol Delivery of Lung Cancer Drugs
    Brian Hansen; Fiscal Year: 2002
    ..None of the currently available pulmonary drug delivery systems (CFC-propellant metered dose inhalers, aqueous solution nebulizers, and dry powder inhalers) are capable of forming respirable particles of such ..
  4. Asthma Treatment with a Novel Drug Aerosol Generator
    William Shen; Fiscal Year: 2004
    ..The most common method to deliver asthma medications to patients is metered dose inhalers (MDIs)...
  5. Asthma medication delivery with a new incentive spacer
    Peter Le Souef; Fiscal Year: 2005
    ..or a new toy module designed for the device compromises in the containment and delivery of aerosols from Metered Dose Inhalers (MDIs)...
  6. LUNG DRUG DELIVERY WITH CARBON DIOXIDE AEROSOL INHALERS
    Brian Hansen; Fiscal Year: 2001
    ..from the Investigator's Abstract): The chlorofluorocarbon (CFC) propellants currently being used in metered dose inhalers for pulmonary drug delivery are being phased out due to their high ozone depletion potential...
  7. Development of a dry powder inhaler dispersion mechanism
    TIMOTHY CROWDER; Fiscal Year: 2003
    ..Oriel's DPI could replace pressurized metered dose inhalers (pMDIs) and will decrease development time and costs for new pharmaceutical aerosol formulations...
  8. A HAND HELD ULTRASONIC METERED DOSE INHALER
    Andrew Kaufman; Fiscal Year: 2002
    ..aerosol inhalation delivery system, based on ultrasonic atomization, to replace or augment current metered dose inhalers for both solutions and suspensions...
  9. SCLERODERMA LUNG STUDY
    Donald Tashkin; Fiscal Year: 2003
    ..abstract_text> ..
  10. Distal Lung Inflammation Effect on Asthma Exacerbations
    Donald Tashkin; Fiscal Year: 2008
    ..This study has the potential to clarify the contribution of the "silent zone" to the persistent morbidity encountered with asthma. ..
  11. LUNG HEALTH STUDY--LONG TERM FOLLOW UP
    Donald Tashkin; Fiscal Year: 2002
    ..All ten of the original LHS clinical centers plan to participate in this study. To minimize bias, all surviving participants of the LHS will be invited to participate, giving a potential sample size of 5600. ..
  12. Elucidation of the Lipoxygenase-Mediated Pathway of Lun*
    PAUL MYRDAL; Fiscal Year: 2005
    ..abstract_text> ..
  13. ASTHMA CLINICAL RESEARCH NETWORK (ACRN)
    Stephen Peters; Fiscal Year: 2007
    ....
  14. CONTROL OF IGE MEDIATED PULMONARY INFLAMMATION IN HUMANS
    Stephen Peters; Fiscal Year: 2001
    ....
  15. Adherence & Treatment Outcome in Adolescents in CAMPCS
    Bruce Bender; Fiscal Year: 2003
    ..abstract_text> ..
  16. ASSESSMENT MODE AND VALIDITY OF SELF-REPORTS IN CHILDREN
    Bruce Bender; Fiscal Year: 2004
    ..Results from this investigation are expected to have immediate and direct implication for clinical research in asthma and with other chronic conditions. ..
  17. Clinical Trial of Acid Reflux Therapy in Asthma
    Robert Wise; Fiscal Year: 2007
    ..Pre-specified subgroup analyses will be conducted to determine if there are clinical or demographic characteristics that predict benefit from treatment of GERD in asthma. ..
  18. CARE Network - Madison Clinical Center
    ROBERT LEMANSKE; Fiscal Year: 2008
    ..abstract_text> ..
  19. Sustained Release Pulmonary Delivery for Improved Cystic Fibrosis Treatment
    Hugh Smyth; Fiscal Year: 2008
    ..These R03 feasibility studies, initiate a long term goal of applying drug delivery approaches to CF therapy. [unreadable] [unreadable] [unreadable]..
  20. Naturally occurring T regulatory cells control airway hyperresponsiveness
    Erwin Gelfand; Fiscal Year: 2008
    ..abstract_text> ..
  21. Severe Asthma From Respiratory Infections
    William W Busse; Fiscal Year: 2010
    ..These studies will provide new insights into the mechanisms of asthma, particularly severe disease, and possibilities of new approaches to treatment. ..
  22. Treatment of Severe Persistent Asthma
    ROBERT LEMANSKE; Fiscal Year: 2007
    ..abstract_text> ..
  23. Melatonin Randomized Trial in Insomnia in the Elderly
    Nalaka Gooneratne; Fiscal Year: 2006
    ..abstract_text> ..
  24. The Placebo Effect in Asthma
    Robert Wise; Fiscal Year: 2005
    ..Understanding the placebo response can lead to improvements in research and treatment of asthma. ..
  25. CYTOKINE DYSREGULATION, VIRUSES, AND CHILDHOOD ASTHMA
    ROBERT LEMANSKE; Fiscal Year: 2001
    ..The results of these studies will provide information that will be a major step forward in our understanding of the relative influence that genetic and environmental risk factors on the development of childhood asthma. ..
  26. Does Shared Decision-Making Improve Asthma Outcomes?
    ALINE BUIST; Fiscal Year: 2005
    ..All participants will be followed for two years with outcome data collected at 12 and 24 months. If effective, this model can be incorporated into clinical practice to improve asthma outcomes and reduce costs. ..
  27. ROLE OF MELATONIN IN SECONDARY INSOMNIA IN THE ELDERLY
    Nalaka Gooneratne; Fiscal Year: 2004
    ....
  28. SCLERODERMA LUNG STUDY
    Robert Wise; Fiscal Year: 2003
    ..abstract_text> ..
  29. Individualized Interventions to Improve Asthma Adherence
    Andrea Apter; Fiscal Year: 2009
    ..We will estimate the incremental cost-effectiveness of PS. ..
  30. INHALED STEROID ADHERENCE IN MODERATE & SEVERE ASTHMA
    Andrea Apter; Fiscal Year: 2004
    ..Upon the foundation of my prior clinical experience and education, this training program is designed to equip me with the additional skills and research experience necessary to become a fully independent investigator. ..
  31. ASTHMA CLINICAL RESEARCH NETWORK
    ROBERT LEMANSKE; Fiscal Year: 2002
    ....
  32. "Improving Pediatric Safety and Quality with Health Car*
    Timothy Ferris; Fiscal Year: 2006
    ..The proposed research will provide quantitative information on the value of CDSS in terms of patient safety, adherence to guidelines, and patient experience of care. ..
  33. MEKK2 Regulation of Mast Cell/T Cell Cytokine Production
    Erwin Gelfand; Fiscal Year: 2003
    ..The studies will also define MEKK2 and ERK5 as targets for drug discovery for the control of allergic inflammation. ..
  34. MECHANISMS OF RHINOVIRUS INDUCED ASTHMA
    William Busse; Fiscal Year: 2002
    ..The proposed studies will provide new evidence as the mechanisms by which RV-infected epithelial cells cause granulocytic bronchial inflammation and asthma exacerbations. ..