quantum dots

Summary

Summary: Nanometer sized fragments (the dots) of semiconductor crystalline material which emits PHOTONS. The wavelength is based on the quantum confinement size of the dot. They are brighter and more persistent than organic chemical INDICATORS. They can be embedded in MICROBEADS for high throughput ANALYTICAL CHEMISTRY.

Top Publications

  1. pmc A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors
    Ron Hardman
    Nicholas School of the Environment and Earth Sciences, Duke University, Durham, North Carolina 27708, USA
    Environ Health Perspect 114:165-72. 2006
  2. pmc Renal clearance of quantum dots
    Hak Soo Choi
    Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Room SL B05, Boston, Massachusetts 02215, USA
    Nat Biotechnol 25:1165-70. 2007
  3. ncbi Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects
    Weibo Cai
    Molecular Imaging Program MIPS, Department of Radiology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nano Lett 6:669-76. 2006
  4. doi Mechanisms of quantum dot nanoparticle cellular uptake
    Leshuai W Zhang
    Center for Chemical Toxicology Research and Pharmacokinetics, Department of Clinical Science, North Carolina State University, Raleigh, North Carolina 27606, USA
    Toxicol Sci 110:138-55. 2009
  5. doi Aqueous-phase synthesis of highly luminescent CdTe/ZnTe core/shell quantum dots optimized for targeted bioimaging
    Wing Cheung Law
    The Institute for Lasers, Photonics and Biophotonics and Department of Electrical Engineering The State University of New York at Buffalo Buffalo, NY 14260 4200, USA
    Small 5:1302-10. 2009
  6. pmc Quantum dots for live cells, in vivo imaging, and diagnostics
    X Michalet
    Department of Chemistry and Biochemistry, University of California, 607 Charles E Young Drive East, Los Angeles, CA 90095, USA
    Science 307:538-44. 2005
  7. ncbi Quantum dot bioconjugates for imaging, labelling and sensing
    Igor L Medintz
    Center for Bio Molecular Science and Engineering, Code 6900, US Naval Research Laboratory, Washington, DC 20375, USA
    Nat Mater 4:435-46. 2005
  8. pmc Proton-sponge coated quantum dots for siRNA delivery and intracellular imaging
    Maksym V Yezhelyev
    Winship Cancer Institute, Emory University, Atlanta, Georgia 30322, USA
    J Am Chem Soc 130:9006-12. 2008
  9. pmc Particle size, surface coating, and PEGylation influence the biodistribution of quantum dots in living mice
    Meike L Schipper
    Molecular Imaging Program at Stanford MIPS, Department of Radiology, Bio X Program, Stanford University, 318 Campus Drive, Palo Alto, CA 94305 5427, USA
    Small 5:126-34. 2009
  10. doi Emissive ZnO-graphene quantum dots for white-light-emitting diodes
    Dong Ick Son
    Interface Control Research Center, Future Convergence Research Division, Korea Institute of Science and Technology, Hwarangro 14 gil 5, Seoul, Korea
    Nat Nanotechnol 7:465-71. 2012

Detail Information

Publications399 found, 100 shown here

  1. pmc A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors
    Ron Hardman
    Nicholas School of the Environment and Earth Sciences, Duke University, Durham, North Carolina 27708, USA
    Environ Health Perspect 114:165-72. 2006
    ..g., carbon nanotubes, fullerene derivatives, and quantum dots (QDs)], with widespread applications in fields such as medicine, plastics, energy, electronics, and aerospace...
  2. pmc Renal clearance of quantum dots
    Hak Soo Choi
    Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Room SL B05, Boston, Massachusetts 02215, USA
    Nat Biotechnol 25:1165-70. 2007
    ..Using intravenously administered quantum dots in rodents as a model system, we have precisely defined the requirements for renal filtration and urinary ..
  3. ncbi Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects
    Weibo Cai
    Molecular Imaging Program MIPS, Department of Radiology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nano Lett 6:669-76. 2006
    ..in vivo targeting and imaging of tumor vasculature using arginine-glycine-aspartic acid (RGD) peptide-labeled quantum dots (QDs)...
  4. doi Mechanisms of quantum dot nanoparticle cellular uptake
    Leshuai W Zhang
    Center for Chemical Toxicology Research and Pharmacokinetics, Department of Clinical Science, North Carolina State University, Raleigh, North Carolina 27606, USA
    Toxicol Sci 110:138-55. 2009
    Due to the superior photoemission and photostability characteristics, quantum dots (QD) are novel tools in biological and medical applications. However, the toxicity and mechanism of QD uptake are poorly understood...
  5. doi Aqueous-phase synthesis of highly luminescent CdTe/ZnTe core/shell quantum dots optimized for targeted bioimaging
    Wing Cheung Law
    The Institute for Lasers, Photonics and Biophotonics and Department of Electrical Engineering The State University of New York at Buffalo Buffalo, NY 14260 4200, USA
    Small 5:1302-10. 2009
    Semiconductor quantum dots (QDs) have traditionally been synthesized in organic phase and transferred to aqueous solution by functionalizing their surface with silica, polymers, short-chain thiol ligand, or phospholipid micelles...
  6. pmc Quantum dots for live cells, in vivo imaging, and diagnostics
    X Michalet
    Department of Chemistry and Biochemistry, University of California, 607 Charles E Young Drive East, Los Angeles, CA 90095, USA
    Science 307:538-44. 2005
    Research on fluorescent semiconductor nanocrystals (also known as quantum dots or qdots) has evolved over the past two decades from electronic materials science to biological applications...
  7. ncbi Quantum dot bioconjugates for imaging, labelling and sensing
    Igor L Medintz
    Center for Bio Molecular Science and Engineering, Code 6900, US Naval Research Laboratory, Washington, DC 20375, USA
    Nat Mater 4:435-46. 2005
    One of the fastest moving and most exciting interfaces of nanotechnology is the use of quantum dots (QDs) in biology...
  8. pmc Proton-sponge coated quantum dots for siRNA delivery and intracellular imaging
    Maksym V Yezhelyev
    Winship Cancer Institute, Emory University, Atlanta, Georgia 30322, USA
    J Am Chem Soc 130:9006-12. 2008
    ..nanoparticles for short-interfering RNA (siRNA) delivery and imaging based on the use of semiconductor quantum dots (QDs) and proton-absorbing polymeric coatings (proton sponges)...
  9. pmc Particle size, surface coating, and PEGylation influence the biodistribution of quantum dots in living mice
    Meike L Schipper
    Molecular Imaging Program at Stanford MIPS, Department of Radiology, Bio X Program, Stanford University, 318 Campus Drive, Palo Alto, CA 94305 5427, USA
    Small 5:126-34. 2009
    ..of particle size, PEGylation, and surface coating on the quantitative biodistribution of near-infrared-emitting quantum dots (QDs) in mice...
  10. doi Emissive ZnO-graphene quantum dots for white-light-emitting diodes
    Dong Ick Son
    Interface Control Research Center, Future Convergence Research Division, Korea Institute of Science and Technology, Hwarangro 14 gil 5, Seoul, Korea
    Nat Nanotechnol 7:465-71. 2012
    ..Here, we use a simple solution method to prepare emissive hybrid quantum dots consisting of a ZnO core wrapped in a shell of single-layer graphene...
  11. doi Deep ultraviolet photoluminescence of water-soluble self-passivated graphene quantum dots
    Libin Tang
    Department of Applied Physics, The Hong Kong Polytechnic University, Hong Kong SAR
    ACS Nano 6:5102-10. 2012
    Glucose-derived water-soluble crystalline graphene quantum dots (GQDs) with an average diameter as small as 1.65 nm (∼5 layers) were prepared by a facile microwave-assisted hydrothermal method...
  12. ncbi Quantum dot-aptamer conjugates for synchronous cancer imaging, therapy, and sensing of drug delivery based on bi-fluorescence resonance energy transfer
    Vaishali Bagalkot
    Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nano Lett 7:3065-70. 2007
    ..We demonstrate the specificity and sensitivity of this nanoparticle conjugate as a cancer imaging, therapy and sensing system in vitro...
  13. doi Intracellular delivery of quantum dots mediated by a histidine- and arginine-rich HR9 cell-penetrating peptide through the direct membrane translocation mechanism
    Betty R Liu
    Department of Natural Resources and Environmental Studies, National Dong Hwa University, Shoufeng, Hualien, Taiwan
    Biomaterials 32:3520-37. 2011
    Functional peptides that transfer biomaterials, such as semiconductor quantum dots (QDs), into cells in biomaterial research have been developed in recent years...
  14. pmc Induction of autophagy in porcine kidney cells by quantum dots: a common cellular response to nanomaterials?
    Stephan T Stern
    Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick, Inc, NCI Frederick, Frederick, Maryland 21702, USA
    Toxicol Sci 106:140-52. 2008
    b>Quantum dots (QDs) are being investigated as novel in vivo imaging agents. The leaching of toxic metals from these QDs in biological systems is of great concern...
  15. doi Fluorescence nanoparticles "quantum dots" as drug delivery system and their toxicity: a review
    Shirin Ghaderi
    Centre for Nanotechnology and Regenerative Medicine, Division of Surgery and Interventional Science, University College London, UK
    J Drug Target 19:475-86. 2011
    Fluorescence nanocrystals or quantum dots (QDs) are engineered nanoparticles (NP) that have shown great promise with potential for many biological and biomedical applications, especially in drug delivery/activation and cellular imaging...
  16. doi Cadmium-free CuInS2/ZnS quantum dots for sentinel lymph node imaging with reduced toxicity
    Thomas Pons
    Laboratoire Physique et Etude des Materiaux, CNRS UPR0005, ESPCI, 10 rue Vauquelin, 75005 Paris, France
    ACS Nano 4:2531-8. 2010
    Semiconductor quantum dots (QDs) could significantly impact the performance of biomedical near-infrared (NIR) imaging by providing fluorescent probes that are brighter and more photostable than conventional organic dyes...
  17. ncbi Use of fluorescent quantum dot bioconjugates for cellular imaging of immune cells, cell organelle labeling, and nanomedicine: surface modification regulates biological function, including cytotoxicity
    Akiyoshi Hoshino
    International Clinical Research Center, Research Institute, International Medical Center of Japan, 1 21 1 Toyama, Shinjuku ku, Tokyo 162 8655, Japan
    J Artif Organs 10:149-57. 2007
    ..Nanoscale products, including carbon nanotubes, fullerene derivatives, and nanocrystal quantum dots (QDs), are wide spread as novel tools in various fields, not only in materials engineering, electronics, ..
  18. ncbi Cell-penetrating quantum dots based on multivalent and endosome-disrupting surface coatings
    Hongwei Duan
    Department of Biomedical Engineering, Emory University, Atlanta, Georgia, USA
    J Am Chem Soc 129:3333-8. 2007
    We report the development of cell-penetrating quantum dots (QDs) based on the use of multivalent and endosome-disrupting (endosomolytic) surface coatings...
  19. ncbi Quantum dot ligands provide new insights into erbB/HER receptor-mediated signal transduction
    Diane S Lidke
    Department of Molecular Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, D 37077 Gottingen, Germany
    Nat Biotechnol 22:198-203. 2004
    ..using: (i) stable expression of erbB1/2/3 fused with visible fluorescent proteins (VFPs), (ii) fluorescent quantum dots (QDs) bearing epidermal growth factor (EGF-QD) and (iii) continuous confocal laser scanning microscopy and flow ..
  20. pmc Molecular mapping of tumor heterogeneity on clinical tissue specimens with multiplexed quantum dots
    Jian Liu
    Department of Biomedical Engineering and Chemistry, Emory University and Georgia Institute of Technology, 101 Woodruff Circle Suite 2001, Atlanta, Georgia 30322, USA
    ACS Nano 4:2755-65. 2010
    ..Here we report the use of multiplexed quantum dots (QDs) and wavelength-resolved spectral imaging for molecular mapping of tumor heterogeneity on human prostate ..
  21. ncbi Differences in subcellular distribution and toxicity of green and red emitting CdTe quantum dots
    Jasmina Lovric
    Department of Pharmacology and Therapeutics, McGill University, McIntyre Medical Sciences Building, 3655 Promenade Sir William Osler, Montreal, Quebec H3G 1Y6, Canada
    J Mol Med (Berl) 83:377-85. 2005
    b>Quantum dots (QDs) are emerging as alternative or complementary tools to the organic fluorescent dyes currently used in bioimaging...
  22. ncbi Imaging and tracking of tat peptide-conjugated quantum dots in living cells: new insights into nanoparticle uptake, intracellular transport, and vesicle shedding
    Gang Ruan
    Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, 101 Woodruff Circle, Suite 2001, Atlanta, Georgia 30322, USA
    J Am Chem Soc 129:14759-66. 2007
    We report the use of Tat peptide-conjugated quantum dots (Tat-QDs) to examine the complex behavior of nanoparticle probes in live cells, a topic that is of considerable current interest in developing advanced nanoparticle agents for ..
  23. ncbi Self-illuminating quantum dot conjugates for in vivo imaging
    Min Kyung So
    Molecular Imaging Program, Department of Radiology, Stanford University, 1201 Welch Road, Stanford, California 94305 5484, USA
    Nat Biotechnol 24:339-43. 2006
    Fluorescent semiconductor quantum dots hold great potential for molecular imaging in vivo...
  24. ncbi In vivo molecular and cellular imaging with quantum dots
    Xiaohu Gao
    Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, 1639 Pierce Drive, Suite 2001, Atlanta, GA 30322, USA
    Curr Opin Biotechnol 16:63-72. 2005
    b>Quantum dots (QDs), tiny light-emitting particles on the nanometer scale, are emerging as a new class of fluorescent probe for in vivo biomolecular and cellular imaging...
  25. ncbi Sentinel lymph node imaging using quantum dots in mouse tumor models
    Byron Ballou
    Molecular Biosensor and Imaging Center, Department of Biological Sciences, and Department of Chemistry, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, Pennsylvania 15213, USA
    Bioconjug Chem 18:389-96. 2007
    We demonstrate that quantum dots injected into two model tumors rapidly migrate to sentinel lymph nodes...
  26. pmc Biocompatible luminescent silicon quantum dots for imaging of cancer cells
    Folarin Erogbogbo
    Department of Chemical and Biological Engineering, University at Buffalo SUNY, Buffalo, New York 14260 4200, USA
    ACS Nano 2:873-8. 2008
    Luminescent silicon quantum dots (Si QDs) have great potential for use in biological imaging and diagnostic applications...
  27. doi Infrared photodetectors based on CVD-grown graphene and PbS quantum dots with ultrahigh responsivity
    Zhenhua Sun
    Department of Applied Physics and Materials, Research Centre, The Hong Kong Polytechnic University, Hong Kong, China
    Adv Mater 24:5878-83. 2012
    Infrared photodetectors based on single-layer CVD-grown graphene and PbS quantum dots, which are fabricated by solution processing, show ultrahigh responsivities of up to 10(7) A/W under infrared light illumination...
  28. doi A pilot study in non-human primates shows no adverse response to intravenous injection of quantum dots
    Ling Ye
    Institute of Gerontology and Geriatrics, Laboratory Animal Center, Chinese PLA General Hospital, Beijing, PR China
    Nat Nanotechnol 7:453-8. 2012
    b>Quantum dots have been used in biomedical research for imaging, diagnostics and sensing purposes...
  29. doi Graphene quantum dots derived from carbon fibers
    Juan Peng
    Mechanical Engineering and Materials Science Department, Rice University, Houston, Texas 77005, USA
    Nano Lett 12:844-9. 2012
    Graphene quantum dots (GQDs), which are edge-bound nanometer-size graphene pieces, have fascinating optical and electronic properties...
  30. doi Large, solution-processable graphene quantum dots as light absorbers for photovoltaics
    Xin Yan
    Department of Chemistry, Indiana University, Bloomington, Indiana 47405, USA
    Nano Lett 10:1869-73. 2010
    ..It has enabled us to synthesize solution-processable, black graphene quantum dots with uniform size through solution chemistry, and we show that they can be used as sensitizers for solar cells.
  31. doi Enhanced electrochemiluminescence of CdSe quantum dots composited with CNTs and PDDA for sensitive immunoassay
    Guifen Jie
    Key Laboratory of Analytical Chemistry for Life Science Ministry of Education of China, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, PR China
    Biosens Bioelectron 24:3352-8. 2009
    Electrochemiluminescence (ECL) of CdSe quantum dots (QDs) was greatly enhanced by the combination of carbon nanotubes (CNTs) and poly (diallyldimethylammonium chloride) (PDDA) in the CdSe QDs film, and could successfully be used to ..
  32. pmc Dynamic partitioning of a glycosyl-phosphatidylinositol-anchored protein in glycosphingolipid-rich microdomains imaged by single-quantum dot tracking
    Fabien Pinaud
    Department of Chemistry and Biochemistry, University of California at Los Angeles, Los Angeles, CA, USA
    Traffic 10:691-712. 2009
    ..Labeling with quantum dots (qdots) allowed high-resolution and long-term tracking of individual Av-GPI and the classification of their ..
  33. doi Non-specific cellular uptake of surface-functionalized quantum dots
    T A Kelf
    MQ Photonics Centre, Faculty of Science, Macquarie University, Sydney, Australia
    Nanotechnology 21:285105. 2010
    ..The nanoparticles were comprised of commercial quantum dots (QDs) that were highly visible under a fluorescence confocal microscope...
  34. ncbi A CCD-based reader combined quantum dots-labeled lateral flow strips for ultrasensitive quantitative detection of anti-HBs antibody
    Xueqing Zhang
    Department of Bio Nano Science and Engineering, Key Laboratory for Thin Film and Microfabrication Technology of Ministry of Education, National Key Laboratory of Micro Nano Fabrication Technology, Research Institute of Micro Nano Science and Technology, Shanghai Jiao Tong University, Shanghai 200240, P R China
    J Biomed Nanotechnol 8:372-9. 2012
    Herein we reported a CCD-based reader combined quantum dots-labeled lateral flow strips for ultrasensitive quantitative detection of anti-HBs antibody...
  35. ncbi Potentials and pitfalls of fluorescent quantum dots for biological imaging
    Jyoti K Jaiswal
    The Rockefeller University, Box 304, 1230 York Avenue, New York, NY 1002, USA
    Trends Cell Biol 14:497-504. 2004
    Fluorescent semiconductor nanocrystals, known as quantum dots (QDs), have several unique optical and chemical features...
  36. doi Bioconjugation of luminescent silicon quantum dots for selective uptake by cancer cells
    Folarin Erogbogbo
    Department of Chemical and Biological Engineering, The University at Buffalo, State University of New York Buffalo, New York 14260 4200, United States
    Bioconjug Chem 22:1081-8. 2011
    Conventional quantum dots have great potential in cancer-related imaging and diagnostic applications; however, these applications are limited by concerns about the inherent toxicity of their core materials (e.g., cadmium, lead)...
  37. doi Quantum dots, lighting up the research and development of nanomedicine
    Yunqing Wang
    Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, China
    Nanomedicine 7:385-402. 2011
    b>Quantum dots (QDs) have proven themselves as powerful inorganic fluorescent probes, especially for long term, multiplexed imaging and detection...
  38. doi Toxicity of nanocrystal quantum dots: the relevance of surface modifications
    Akiyoshi Hoshino
    Vice Director s Lab, Research Institute, National Center for Global Health and Medicine, Shinjuku ku, Tokyo, Japan
    Arch Toxicol 85:707-20. 2011
    ..In particular, nanocrystal quantum dots (QDs) have been widely used in biological and medical studies because of their far brighter photoemission and ..
  39. pmc Near-infrared quantum dots as optical probes for tumor imaging
    Jinhao Gao
    Molecular Imaging Program at Stanford, Department of Radiology and Bio X Program, School of Medicine, Stanford University, 1201 Welch Road, Stanford, CA 94305 5484, USA
    Curr Top Med Chem 10:1147-57. 2010
    ..be the fastest growing area for bioanalysis, and the major reason is the research on fluorescence semiconductor quantum dots (QDs) and dyes have evolved over the past two decades...
  40. pmc Cell-penetrating peptide-functionalized quantum dots for intracellular delivery
    Betty R Liu
    Department of Natural Resources and Environmental Studies, National Dong Hwa University, Hualien 97401, Taiwan
    J Nanosci Nanotechnol 10:7897-905. 2010
    b>Quantum dots (QDs) are luminescent semiconductor nanocrystals that are widely used as fluorescent probes in biomedical applications, including cellular imaging and tumor tracking...
  41. pmc State of academic knowledge on toxicity and biological fate of quantum dots
    Jennifer L Pelley
    Regulatory Governance Initiative, School of Public Policy and Administration, Carleton University, Ottawa, Ontario K1S5B6, Canada
    Toxicol Sci 112:276-96. 2009
    b>Quantum dots (QDs), an important class of emerging nanomaterial, are widely anticipated to find application in many consumer and clinical products in the near future...
  42. ncbi Near-complete suppression of quantum dot blinking in ambient conditions
    Sungchul Hohng
    Physics Department, University of Illinois, Urbana Champaign, Urbana, Illinois 61801, USA
    J Am Chem Soc 126:1324-5. 2004
    Colloidal semiconductor quantum dots are attractive fluorophores for multicolor imaging because of broad absorption and narrow emission spectra, and they are brighter and far more photostable than organic dyes...
  43. doi A novel sensitive immunoassay by nucleic acid barcode dot and its application in the detection of prostate-specific antigen
    Xiao Li Kong
    Clinical Medical Research Center, The 2nd Clinic Medicine College Shenzhen People s Hospital, Jinan University, Shenzhen, PR China
    Clin Chem Lab Med 48:279-83. 2010
    ..It also requires specialized equipment, which limits its application. We introduce a nano-nucleic acid barcode dot detection technology to determine ultramicro concentrations of protein. The method is simple, quick and accurate...
  44. doi Quantum dot-based resonance energy transfer and its growing application in biology
    Igor L Medintz
    US Naval Research Laboratory, Center for Bio Molecular Science and Engineering, Code 6910, and Division of Optical Sciences, Code 5611, 4555 Overlook Ave, S W Washington DC, 20375, USA
    Phys Chem Chem Phys 11:17-45. 2009
    ..made in the past few years in investigating fluorescence resonance energy transfer (FRET) using semiconductor quantum dots (QDs) and the application of QD-based FRET to probe specific biological processes...
  45. doi New opportunities in multiplexed optical bioanalyses using quantum dots and donor-acceptor interactions
    W Russ Algar
    Chemical Sensors Group, Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road North, Mississauga, ON L5L 1C6, Canada
    Anal Bioanal Chem 398:2439-49. 2010
    ..are generated in response to biorecognition through modulation of the photoluminescence of populations of quantum dots with different emission colors...
  46. ncbi Semiconductor quantum dots for photodynamic therapy
    Anna C S Samia
    Center for Chemical Dynamics and Nanomaterials Research, Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Am Chem Soc 125:15736-7. 2003
    ..Both mechanisms result in the generation of reactive singlet oxygen species that can be used for PDT cancer therapy...
  47. ncbi Use of quantum dots for live cell imaging
    Jyoti K Jaiswal
    Rockefeller University, Laboratory of Cellular Biophysics, 1230 York Avenue, New York, New York 10021, USA
    Nat Methods 1:73-8. 2004
  48. ncbi Targeted quantum dot conjugates for siRNA delivery
    Austin M Derfus
    Department of Bioengineering, University of California at San Diego, La Jolla, California 92093, USA
    Bioconjug Chem 18:1391-6. 2007
    ..By designing the siRNA sequence against a therapeutic target (e.g., oncogene) instead of EGFP, this technology may be ultimately adapted to simultaneously treat and image metastatic cancer...
  49. doi Molecular imaging of tumor angiogenesis using alphavbeta3-integrin targeted multimodal quantum dots
    Willem J M Mulder
    Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    Angiogenesis 12:17-24. 2009
    ..Fluorescence imaging allowed whole-body investigation of angiogenic activity. Using these quantum dots and the aforementioned imaging modalities, the angiogenic tumor vasculature was readily detected with the ..
  50. ncbi Imaging the lateral diffusion of membrane molecules with quantum dots
    Hiroko Bannai
    INSERM U789, Biologie Cellulaire de la Synapse N and P, Ecole Normale Superieure Paris, 46, rue d Ulm 75005 Paris, France
    Nat Protoc 1:2628-34. 2006
    ..This technique makes use of fluorescent semiconductor nanocrystals, quantum dots (QDs), as a probe to detect membrane molecules of interest...
  51. pmc Quantum dots and nanoparticles for photodynamic and radiation therapies of cancer
    Petras Juzenas
    Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Rikshospitalet University Hospital, Montebello, 0310 Oslo, Norway
    Adv Drug Deliv Rev 60:1600-14. 2008
    Semiconductor quantum dots and nanoparticles composed of metals, lipids or polymers have emerged with promising applications for early detection and therapy of cancer...
  52. pmc Characterization of Eag1 channel lateral mobility in rat hippocampal cultures by single-particle-tracking with quantum dots
    David Gomez-Varela
    Department of Molecular Biology of Neuronal Signals, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    PLoS ONE 5:e8858. 2010
    ..Using a specific extracellular antibody and quantum dots we reveal and characterize lateral mobility as a faster mechanism to dynamically control the number of ..
  53. pmc Persistent tissue kinetics and redistribution of nanoparticles, quantum dot 705, in mice: ICP-MS quantitative assessment
    Raymond S H Yang
    Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Zhunan, Taiwan
    Environ Health Perspect 115:1339-43. 2007
    b>Quantum dots (QDs) are autofluorescent semiconductor nanocrystals that can be used for in vivo biomedical imaging. However, we know little about their in vivo disposition and health consequences.
  54. doi Quantum dots-based double-color imaging of HER2 positive breast cancer invasion
    Xiu li Liu
    Department of Oncology, Zhongnan Hospital of Wuhan University, No 169 Donghu Road, Wuchang District, Wuhan 430071, PR China
    Biochem Biophys Res Commun 409:577-82. 2011
    ..Yet, there has been a lack of directly observable evidence to support such notion. Here we report a quantum dots (QDs)-based double-color imaging technique to simultaneously show the HER2 level on BC cells and the type IV ..
  55. ncbi Highly efficient multiple exciton generation in colloidal PbSe and PbS quantum dots
    Randy J Ellingson
    Center for Basic Sciences, National Renewable Energy Laborarory, Golden, Colorado 80401, USA
    Nano Lett 5:865-71. 2005
    ..report ultra-efficient multiple exciton generation (MEG) for single photon absorption in colloidal PbSe and PbS quantum dots (QDs)...
  56. doi The impact of different nanoparticle surface chemistry and size on uptake and toxicity in a murine macrophage cell line
    Martin J D Clift
    Applied Research Centre for Health, Environment and Society, Biomedicine and Sport Science Research Group, School of Life Sciences, Napier University, 10 Colinton Road, Edinburgh, EH10 5DT, UK
    Toxicol Appl Pharmacol 232:418-27. 2008
    This study investigated the uptake, kinetics and cellular distribution of different surface coated quantum dots (QDs) before relating this to their toxicity. J774...
  57. doi Quantum dots-based immunofluorescence technology for the quantitative determination of HER2 expression in breast cancer
    Chuang Chen
    Department of Oncology, Zhongnan Hospital of Wuhan University, Wuchang District, PR China
    Biomaterials 30:2912-8. 2009
    ..b>Quantum dots (QDs)-based probes provide a potentially important new method for HER2 detection in clinical practice...
  58. ncbi On the cyto-toxicity caused by quantum dots
    Amane Shiohara
    Department of Medical Ecology and Informatics, Research Institute, International Medical Center of Japan, 1 21 1, Toyama, Shinjuku ku, Tokyo 162 8655, Japan
    Microbiol Immunol 48:669-75. 2004
    b>Quantum dots (QDs) such as CdSe QDs have been introduced as new fluorophores. The QDs conjugated with antibody are starting to be widely used for immunostaining...
  59. doi Probing cellular events, one quantum dot at a time
    Fabien Pinaud
    Laboratoire Kastler Brossel, CNRS Unité de recherche 8552, Physics and Biology Department, Ecole Normale Superieure, Universite Pierre et Marie Curie, Paris 6, Paris, France
    Nat Methods 7:275-85. 2010
    ....
  60. pmc Cadmium-containing nanoparticles: perspectives on pharmacology and toxicology of quantum dots
    Beverly A Rzigalinski
    Department of Pharmacology, Virginia College of Osteopathic Medicine, NanoNeuroLab, Blacksburg, VA 24060, USA
    Toxicol Appl Pharmacol 238:280-8. 2009
    ..The development of cadmium-containing nanoparticles, known as quantum dots, show great promise for treatment and diagnosis of cancer and targeted drug delivery, due to their size-tunable ..
  61. pmc Advances in fluorescence imaging with quantum dot bio-probes
    Fabien Pinaud
    Department of Chemistry and Biochemistry, UCLA, 607 Charles E Young Drive East, Los Angeles, CA 90095, USA
    Biomaterials 27:1679-87. 2006
    ..development and optimization by several groups, fluorescent semiconductor nanocrystals probes, also known as quantum dots or qdots, are now entering the realm of biological applications with much to offer to biologists...
  62. ncbi From diagnostics to therapy: prospects of quantum dots
    Hassan M E Azzazy
    Department of Chemistry and Yousef Jameel Science and Technology Research Center, The American University in Cairo, 113 Kasr El Aini Street, Cairo 11511, Egypt
    Clin Biochem 40:917-27. 2007
    b>Quantum dots (QDs) are among the most promising items in the nanomedicine toolbox...
  63. ncbi Finding fluorescent needles in the cardiac haystack: tracking human mesenchymal stem cells labeled with quantum dots for quantitative in vivo three-dimensional fluorescence analysis
    Amy B Rosen
    Institute for Molecular Cardiology, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
    Stem Cells 25:2128-38. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  64. ncbi Water-soluble quantum dots for biomedical applications
    William W Yu
    Department of Chemistry, Rice University, Houston, TX 77005, USA
    Biochem Biophys Res Commun 348:781-6. 2006
    ..unique size-dependent optical and electrical properties due to quantum confinement (so they are also called quantum dots)...
  65. doi Delivering quantum dots into cells: strategies, progress and remaining issues
    James B Delehanty
    Center for Bio Molecular Science and Engineering, Code 6900, U S Naval Research Laboratory, Washington, DC, USA
    Anal Bioanal Chem 393:1091-105. 2009
    The use of semiconductor quantum dots (QDs) in biological sensing and labeling continues to grow with each year...
  66. doi Quantum dots versus organic dyes as fluorescent labels
    Ute Resch-Genger
    Federal Institute for Materials Research and Testing, Richard Willstaetter Str 11, 12489 Berlin, Germany
    Nat Methods 5:763-75. 2008
    ..One of the most exciting, yet also controversial, advances in label technology is the emerging development of quantum dots (QDs)--inorganic nanocrystals with unique optical and chemical properties but complicated surface chemistry--as ..
  67. doi Cellular and transcriptional response of Pseudomonas stutzeri to quantum dots under aerobic and denitrifying conditions
    Yu Yang
    Department of Civil and Environmental Engineering, Rice University, Houston, Texas 77005, USA
    Environ Sci Technol 45:4988-94. 2011
    Pseudomonas stutzeri was exposed to quantum dots (QDs) with three different surface coatings (anionic polymaleic anhydride-alt-1-octadecene (PMAO), cationic polyethylenimine (PEI), and carboxyl QDs) under both aerobic and anaerobic (..
  68. ncbi Nanocomposite liposomes containing quantum dots and anticancer drugs for bioimaging and therapeutic delivery: a comparison of cationic, PEGylated and deformable liposomes
    Chih Jen Wen
    School of Medicine, Chang Gung University, Kweishan, Taoyuan, Taiwan
    Nanotechnology 24:325101. 2013
    Multifunctional liposomes loaded with quantum dots (QDs) and anticancer drugs were prepared for simultaneous bioimaging and drug delivery...
  69. doi In vivo real-time visualization of tissue blood flow and angiogenesis using Ag2S quantum dots in the NIR-II window
    Chunyan Li
    Suzhou Key Laboratory of Nanomedical Characterization, Division of Nanobiomedicine and i Lab, Suzhou Institute of Nano tech and Nano bionics, Chinese Academy of Sciences, Suzhou 215123, China
    Biomaterials 35:393-400. 2014
    ..Here, we present that Ag2S quantum dots (QDs), containing no toxic ions, exhibiting long circulation time and high stability, act as a new kind of ..
  70. doi Organ distribution of quantum dots after intraperitoneal administration, with special reference to area-specific distribution in the brain
    Shingo Kato
    Department of Pathology and Applied Neurobiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Nanotechnology 21:335103. 2010
    b>Quantum dots (QDs) are well known for their potential application in biosensing, ex vivo live-cell imaging and in vivo animal targeting...
  71. ncbi Unmodified cadmium telluride quantum dots induce reactive oxygen species formation leading to multiple organelle damage and cell death
    Jasmina Lovric
    Department of Pharmacology and Therapeutics, McGill University, 3655 Promenade Sir William Osler, McIntyre Medical Sciences Building, Room 1314, Montreal, Quebec H3G 1Y6, Canada
    Chem Biol 12:1227-34. 2005
    b>Quantum dots (QDs) are luminescent nanoparticles with unique optical properties that have been exploited for single-cell and whole-animal imaging...
  72. doi Nanotoxicity assessment of quantum dots: from cellular to primate studies
    Ken Tye Yong
    School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore 639798, Singapore
    Chem Soc Rev 42:1236-50. 2013
    Tremendous research efforts have been devoted to fabricating high quality quantum dots (QDs) for applications in biology and medicine. Much of this research was pursued with an ultimate goal of using QDs in clinical applications...
  73. doi Robust DNA-functionalized core/shell quantum dots with fluorescent emission spanning from UV-vis to near-IR and compatible with DNA-directed self-assembly
    Zhengtao Deng
    The Biodesign Institute and Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona 85287, USA
    J Am Chem Soc 134:17424-7. 2012
    ..However, achieving DNA-functionalized semiconductor quantum dots (QDs) that are robust enough to withstand precipitation at high temperature and ionic strength through simple ..
  74. pmc Site-specific labeling of enveloped viruses with quantum dots for single virus tracking
    Kye Il Joo
    Mork Family Department of Chemical Engineering and Materials Science, University of Southern California, Los Angeles, California 90089, USA
    ACS Nano 2:1553-62. 2008
    This study reports a general method of labeling enveloped viruses with semiconductor quantum dots (QDs) for use in single virus trafficking studies...
  75. ncbi Dual-function probe for PET and near-infrared fluorescence imaging of tumor vasculature
    Weibo Cai
    Molecular Imaging Program at Stanford MIPS, Department of Radiology, and Bio X Program, Stanford University School of Medicine, Stanford, CA 94305 5484, USA
    J Nucl Med 48:1862-70. 2007
    To date, the in vivo imaging of quantum dots (QDs) has been mostly qualitative or semiquantitative...
  76. doi ROS-mediated apoptotic cell death in prostate cancer LNCaP cells induced by biosurfactant stabilized CdS quantum dots
    Braj R Singh
    Centre of Excellence in Materials Science Nanomaterials, Department of Applied Physics, Z H College of Engg and Tech, Aligarh Muslim University, Aligarh 202002, Uttar Pradesh, India
    Biomaterials 33:5753-67. 2012
    Cadmium sulfide (CdS) quantum dots (QDs) have raised great attention because of their superior optical properties and wide utilization in biological and biomedical studies...
  77. pmc Quantum dot-based theranostics
    Yi Ping Ho
    Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA
    Nanoscale 2:60-8. 2010
    Luminescent semiconductor nanocrystals, also known as quantum dots (QDs), have advanced the fields of molecular diagnostics and nanotherapeutics...
  78. doi Ultrasmall near-infrared Ag2Se quantum dots with tunable fluorescence for in vivo imaging
    Yi Ping Gu
    Key Laboratory of Analytical Chemistry for Biology and Medicine Ministry of Education, College of Chemistry and Molecular Sciences, Research Center for Nanobiology and Nanomedicine MOE 985 Innovative Platform, Wuhan University, Wuhan, 430072, PR China
    J Am Chem Soc 134:79-82. 2012
    ..with the binding of silver ions and alanine in a quasi-biosystem to obtain ultrasmall, near-infrared Ag(2)Se quantum dots (QDs) with tunable fluorescence at 90 °C in aqueous solution...
  79. doi Are quantum dots toxic? Exploring the discrepancy between cell culture and animal studies
    Kim M Tsoi
    Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, M5S 3G9, Canada
    Acc Chem Res 46:662-71. 2013
    Despite significant interest in developing quantum dots (QDs) for biomedical applications, many researchers are convinced that QDs will never be used for treating patients because of their potential toxicity...
  80. doi Immunocompetence and alterations in hepatic gene expression in rainbow trout exposed to CdS/CdTe quantum dots
    F Gagne
    Fluvial Ecosystem Research, Aquatic Ecosystem Research Protection, Water Science and Technology, Environment Canada, Montreal, Quebec, Canada
    J Environ Monit 12:1556-65. 2010
    Cadmium (Cd) tellurium quantum dots (QDs) are long-lived fluorescent nanocrystals that have the ability to produce potentially toxic reactive oxygen species at the surface of the nanoparticle and release toxic cadmium ions...
  81. pmc Clathrin-mediated endocytosis in living host cells visualized through quantum dot labeling of infectious hematopoietic necrosis virus
    Haibin Liu
    State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Xiaohongshan 44, Wuchang, Wuhan 430071, People s Republic of China
    J Virol 85:6252-62. 2011
    ..In this study, quantum dots (QDs) were used as fluorescent labels for sensitive, long-term tracking of IHNV entry...
  82. ncbi NIR-emitting colloidal quantum dots having 26% luminescence quantum yield in buffer solution
    Sean Hinds
    Department of Electrical and Computer Engineering, University of Toronto, 10 King s College Road, Toronto, Ontario M5S 3G4, Canada
    J Am Chem Soc 129:7218-9. 2007
  83. pmc Functional characterization and atomic force microscopy of a DNA repair protein conjugated to a quantum dot
    Hong Wang
    Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA
    Nano Lett 8:1631-7. 2008
    b>Quantum dots (QDs) possess highly desirable optical properties that make them ideal fluorescent labels for studying the dynamic behavior of proteins...
  84. pmc Real-time intravital imaging of RGD-quantum dot binding to luminal endothelium in mouse tumor neovasculature
    Bryan Ronain Smith
    The Molecular Imaging Program at Stanford MIPS, Department of Radiology and Bio X Program, Stanford University, Stanford, California 94305, USA
    Nano Lett 8:2599-606. 2008
    ..Adopting quantum dots (qdots) for their excellent brightness, photostability, monodispersity, and fluorescent yield, we link arginine-..
  85. doi Transforming C60 molecules into graphene quantum dots
    Jiong Lu
    Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore
    Nat Nanotechnol 6:247-52. 2011
    ..Here, we show that geometrically well-defined graphene quantum dots can be synthesized on a ruthenium surface using C(60) molecules as a precursor...
  86. doi Strong enhancement of solar cell efficiency due to quantum dots with built-in charge
    Kimberly A Sablon
    U S Army Research Laboratory, Adelphi, Maryland 20783, United States
    Nano Lett 11:2311-7. 2011
    ..The n-doped device was compared with GaAs reference cell, undoped, and p-doped devices. We found that the quantum dots with built-in charge (Q-BIC) enhance electron intersubband quantum dot transitions, suppress fast electron ..
  87. pmc Identification of three distinct functional sites of insulin-mediated GLUT4 trafficking in adipocytes using quantitative single molecule imaging
    Hideaki Fujita
    Tohoku University Biomedical Engineering Research Organization, Sendai, Miyagi, 980 8575, Japan
    Mol Biol Cell 21:2721-31. 2010
    ..In addition, our novel approach revealed the possibility that, in certain insulin-resistant states, derangements in GLUT4 behavior can impair insulin-responsive GLUT4 translocation...
  88. doi Short term inhalation toxicity of a liquid aerosol of CdS/Cd(OH)₂ core shell quantum dots in male Wistar rats
    L Ma-Hock
    BASF SE, Experimental Toxicology and Ecology, 67056 Ludwigshafen, Germany
    Toxicol Lett 208:115-24. 2012
    Colloidal quantum dots (QD) show great promise as fluorescent markers. The QD used in this study were obtained in aqueous medium rather than the widely used colloidal QD...
  89. ncbi Silica-coated nanocomposites of magnetic nanoparticles and quantum dots
    Dong Kee Yi
    Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore 138669
    J Am Chem Soc 127:4990-1. 2005
    b>Quantum dots (QDs) and magnetic nanoparticles (MPs) are of interest for biological imaging, drug targeting, and bioconjugation because of their unique optoelectronic and magnetic properties, respectively...
  90. pmc Small, mobile FcepsilonRI receptor aggregates are signaling competent
    Nicholas L Andrews
    Department of Pathology and Cancer Research and Treatment Center, University of New Mexico, Albuquerque, NM 87131, USA
    Immunity 31:469-79. 2009
    ..We propose that immobility is a feature of highly crosslinked immunoreceptor aggregates and a trigger for receptor internalization, but is not required for tyrosine kinase activation leading to secretion...
  91. pmc In vitro toxicity assessment of amphiphillic polymer-coated CdSe/ZnS quantum dots in two human liver cell models
    Wesley E Smith
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98195, United States
    ACS Nano 6:9475-84. 2012
    Semiconductor quantum dots (Qdots) are a promising new technology with benefits in the areas of medical diagnostics and therapeutics. Qdots generally consist of a semiconductor core, capping shell, and surface coating...
  92. pmc Semiconductor quantum dots for biomedicial applications
    Lijia Shao
    Jiangsu Affiliated Cancer Hospital with Nanjing Medical University, Jiangsu Institute of Cancer Prevention and Cure, Nanjing 210009, China
    Sensors (Basel) 11:11736-51. 2011
    Semiconductor quantum dots (QDs) are nanometre-scale crystals, which have unique photophysical properties, such as size-dependent optical properties, high fluorescence quantum yields, and excellent stability against photobleaching...
  93. pmc Blinking and nonradiant dark fraction of water-soluble quantum dots in aqueous solution
    Jie Yao
    School of Applied and Engineering Physics and Field of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 102:14284-9. 2005
    Water-soluble quantum dots (qdots) are now being used in life sciences research to take advantage of their bright, easily excited fluorescence and high photostability...
  94. pmc Long-term persistence and spectral blue shifting of quantum dots in vivo
    James A J Fitzpatrick
    Molecular Biosensor and Imaging Center, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, Pennsylvania 15213, USA
    Nano Lett 9:2736-41. 2009
    b>Quantum dots are a powerful fluorophore family with desirable attributes for fluorescence imaging...
  95. pmc Method for multiplex cellular detection of mRNAs using quantum dot fluorescent in situ hybridization
    Pokman Chan
    Department of Neurology, Mount Sinai School of Medicine, One Gustave L Levy Place, NY 10029, USA
    Nucleic Acids Res 33:e161. 2005
    ..This approach can facilitate the ultrasensitive simultaneous study of multiple mRNA and protein markers in tissue culture and histological section...
  96. ncbi Anomalous behaviors of visible luminescence from graphene quantum dots: interplay between size and shape
    Sung Kim
    Department of Applied Physics, Kyung Hee University, Yongin 446 701, Korea
    ACS Nano 6:8203-8. 2012
    For the application of graphene quantum dots (GQDs) to optoelectronic nanodevices, it is of critical importance to understand the mechanisms which result in novel phenomena of their light absorption/emission...
  97. ncbi Real time in vivo non-invasive optical imaging using near-infrared fluorescent quantum dots
    Nicole Y Morgan
    National Institutes of Health, Bethesda, MD 20892, USA
    Acad Radiol 12:313-23. 2005
    ..For this purpose, the development of novel contrast agents with near-infrared (NIR) fluorescence is especially important. We report on the use of NIR semiconductor nanocrystals in deep-tissue in vivo optical imaging...
  98. doi Biosynthesis of luminescent quantum dots in an earthworm
    S R Stürzenbaum
    Analytical and Environmental Sciences Division, King s College London, London SE1 9NH, UK
    Nat Nanotechnol 8:57-60. 2013
    ..pathway can be exploited to produce luminescent, water-soluble semiconductor cadmium telluride (CdTe) quantum dots that emit in the green region of the visible spectrum when excited in the ultraviolet region...
  99. doi A peptide derived from herpes simplex virus type 1 glycoprotein H: membrane translocation and applications to the delivery of quantum dots
    Annarita Falanga
    Department of Biological Sciences, Division of Biostructures University of Naples Federico II, Napoli, Italy
    Nanomedicine 7:925-34. 2011
    ..We use as cargo molecule quantum dots that do not significantly traverse the membrane bilayer on their own.
  100. doi Quantum dots for fluorescent biosensing and bio-imaging applications
    Jingjing Li
    State Lab of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, PR China
    Analyst 138:2506-15. 2013
    b>Quantum dots (QDs) have been facilitating the development of sensitive fluorescence biosensors over the past two decades due to their high quantum yield, narrow and tunable emission spectrum and good photostability...
  101. doi New generation of chitosan-encapsulated ZnO quantum dots loaded with drug: synthesis, characterization and in vitro drug delivery response
    Q Yuan
    Center for Structural and Functional Materials, University of Louisiana at Lafayette, Lafayette, LA 70504 4130, USA
    Acta Biomater 6:2732-9. 2010
    The objective of the study is to describe a new approach of combining quantum dots technology with anti-cancer drug therapy...

Research Grants78

  1. Novel TIRF microscopy analyzing trafficking & signaling at the cell cortex
    Derek Toomre; Fiscal Year: 2009
    ..Consistent with the recovery act's goal, this funding will provide full-time summer employment for 4 undergraduate students and accelerate scientific achievement of the parent DP2 award...
  2. Mapping for Specialized Domains for FCeRI Signaling &Internalization
    Bridget S Wilson; Fiscal Year: 2013
    ..study the dynamic behavior of receptors in live cell membranes using brightly fluorescent nanoprobes called quantum dots. We will also use our innovative electron microscopy methods to map the distributions of lipids, receptors and ..
  3. CCR3: a molecular marker for neovascular AMD
    Jayakrishna Ambati; Fiscal Year: 2010
    ..Non-invasive in vivo bioimaging using functionalized quantum dots targeting CCR3 detected CNV within the mouse choroid that had not yet invaded the retina and was invisible to ..
  4. Antigen receptor inputs: linking structural, molecular, and cellular responses
    Jonathan P Schneck; Fiscal Year: 2012
    ..In addition we will engineer quantum dots that will present TCR ligands, MHC/peptide or anti-CD3 to naive and activated T cells...
  5. Retinal Imaging of Prognostic Indicators of Atherosclerosis
    Frederick R Haselton; Fiscal Year: 2010
    ..Our imaging agents harness the optical properties of quantum dots (QD) linked to antibodies to color-code different biomarkers within the same imaging field...
  6. Rescuing Niemann-Pick C Disease: Pathways of Liver and Brain Degeneration
    Matthew P Scott; Fiscal Year: 2013
    ..how PNs are affected, we will culture them and track the trafficking of NGF and other molecules labeled with quantum dots. We will use a portable two-photon microscope in combination with organelle dyes to characterize vesicular ..
  7. P63/IGFBP3/BCL2 Control of Corneal Epithelial Homeostasis
    Danielle M Robertson; Fiscal Year: 2011
    ..subcellular trafficking of IGFBP3 (cell fractionation and WB, and biotinylated IGFPB3-streptavidin-conjugated quantum dots using time-lapse confocal microscopy);and characterize the role of dimerization and glycosylation in ..
  8. Cardiac function and PIP2
    Donald W Hilgemann; Fiscal Year: 2013
    ..In the longer term, these fusions will allow the use of quantum dots and Nanogold to study NCX1 trafficking...
  9. Receptors for clostridial neurotoxins
    Edwin R Chapman; Fiscal Year: 2010
    ..We have devised a simple model system, using cultured neurons and toxins labeled with quantum dots, to study the putative movement of BoNTs within and between neurons...
  10. QD-BRET nanosensors for protease detection and imaging
    Jianghong Rao; Fiscal Year: 2012
    ..This new platform is based on quantum dots (QDs) and bioluminescence resonance energy transfer (BRET)...
  11. Multimodal Qdot Probes for Bioimaging of Cells and Tumors in Small Animals
    Shimon Weiss; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Quantum dots (qdots) have emerged as new fluorescent, non-isotopic labels that are thought to have unmatched potentials as novel intravascular probes for both diagnostic (e.g...
  12. Assay for Monitoring Glycemic Control in Diabetics
    Ralph Ballerstadt; Fiscal Year: 2010
    ..kit will be the use aptamers - short oligonucleotides - for specific binding to the protein targets, and quantum dots for fluorescence detection...
  13. Tubulin-Binding Upconversion Nanoparticles for Breast-Cancer Imaging and Therapy
    Chuanbin Mao; Fiscal Year: 2013
    ..In contrast to the down-conversion nanoparticles such as the widely used quantum dots (QDs), the UCNPs can be excited by a longer wavelength light such as near infrared (NIR) light (e.g...
  14. High Resolution Labels for EM
    James F Hainfeld; Fiscal Year: 2012
    ..Labeling has also seen some technological advances, such as the development of quantum dots, ReAsH, and small gold labels, such as amine and thiol reactive gold clusters, FluoroNanogold (combining gold ..
  15. Emory-GA Tech Nanotechnology Center for Personalized an*
    Shuming Nie; Fiscal Year: 2009
    ..Project #1 will develop quantum dots and targeted nanoparticles for cancer molecular imaging (Nie)...
  16. Colloidal Quantum Dot/Well Near-Infrared NanoLabels
    Hua Mao; Fiscal Year: 2010
    ..develop a novel class of commercial products of near infrared (NIR) nanolabels based on colloidal non-cadmium quantum dots, InAs/InP/ZnSe core/shell/shell dots coated with dendron ligands...
  17. Distal effects of botulinum neurotoxins
    Edwin R Chapman; Fiscal Year: 2013
    ..This work will include single particle tracking of toxins conjugated to quantum dots (Qdots) to directly visualize, and quantitatively analyze, transport...
  18. Expanding the Clinical Utility of Ultrasound-Assisted Transdermal Drug Delivery
    ROBERT SAMUEL LANGER; Fiscal Year: 2013
    ..delivery of permeants through skin pre-treated with LFS/SLS by utilizing functionalized nanoparticles (quantum dots and biomimetic gold nanoparticles) to identify optimal permeant properties for passive transdermal delivery of ..
  19. Ion Selective Quantum Dots for Intracellular Mapping of Sodium Sparks in Cardiac
    Heather A Clark; Fiscal Year: 2012
    Ion-selective quantum dots (ISQDs) are ion-selective polymer-based optical nanosensors that incorporate quantum dots (QDs) into the core of the sensor...
  20. Creating Safe Biodegradable Photoluminescent Implant Polymers
    Jian Yang; Fiscal Year: 2013
    ..The most common fluorescent imaging agents include organic dyes, fluorescent proteins and quantum dots (QDs)...
  21. MULTIFUNCTIONAL STIMULI-SENSITIVE PHARMACEUTICAL NANOCARRIERS
    Vladimir P Torchilin; Fiscal Year: 2010
    ..for the intracellular delivery of small drug molecules, large molecules (enzymes, DNA) and nanoparticulates (quantum dots, iron oxide nanoparticles, liposomes)...
  22. Interactions of engineered nanomaterials with lung alveolar epithelium
    EDWARD DAVID CRANDALL; Fiscal Year: 2010
    ..nanomaterials (ENM: examples are fullerenes (composed of >60 carbon atoms), carbon nanotubes (CNT), quantum dots and metal /metal oxide nanoparticles), may be associated with various heart-, blood- and lung-related health ..
  23. Quantitative molecular profiling of tumor biomarkers with multi-color monovalent
    Hongyan Liu; Fiscal Year: 2012
    ..Nanotechnology is becoming a fundamental driver of advances in cancer research. In this regard, bioconjugated quantum dots (QDs) are particularly attractive as an emerging new probe for tumor biomarker profiling owing to its high ..
  24. Flowcell for Biological Imaging with LiquidSTEM
    John Damiano; Fiscal Year: 2013
    ..The use of fluorescent nanoparticles, such as quantum dots (QDs) that contain heavy atoms, allows liquid STEM images to be correlated efficiently with fluorescence images...
  25. Assay for GI Drug Discovery
    LID WONG; Fiscal Year: 2012
    ..Cytoptics Corporation (Cytoptics) proposes to develop a new generation of chloride ion and pH sensing luminous quantum dots (QD) indicators to measure intracellular chloride ion concentrations, [Cl-]i, and pHi for fluorescence ..
  26. Ultra-Low Background NIR Fluorophores for In Vivo Imaging and Image-Guided Surger
    John V Frangioni; Fiscal Year: 2013
    ..This grant builds upon an observation we made two years ago using NIR fluorescent quantum dots (Choi et al., Nature Biotechnol. 2007;25: 1165-70)...
  27. How do Nanoparticles Target Cancer? An In Vivo Experimental/Mathematical Study
    Bryan Ronain Smith; Fiscal Year: 2012
    ..have performed preliminary microscopy experiments on several NP types (with varied physical properties, such as quantum dots and nanotubes) in living mice that display broadly different targeting characteristics across the NP types we ..
  28. Modulation of Qdot nanoparticle toxicity by glutathione in GCL transgenic mice
    TERRANCE JAMES KAVANAGH; Fiscal Year: 2010
    ..Recent advances in nanotechnology have produced a new class of fluorescent nanoparticles, semiconductor quantum dots (QDs)...
  29. Automated Analysis of Skeletal Muscle Fiber Cross-sectional Area and Metabolic Ty
    Patrick M McDonough; Fiscal Year: 2012
    ..and IIx), laminin, and OXPAT in the mouse, and to label the MAbs with organic fluorophores or nanocrystals (aka quantum dots) for use in direct immunocytofluorescence procedures, 2) to enable CyteSeer(R) to perform multichannel analysis ..
  30. Sensitive and multiplexed analysis of cancer biomarkers with QD barcodes
    Xiaohu Gao; Fiscal Year: 2012
    ..The innovation and basic rationale of this technology lies in the novel optical properties of semiconductor quantum dots or QDs (e.g...
  31. Center of Cancer Nanotechnology Excellence Focused on Therapy Response
    Sanjiv S Gambhir; Fiscal Year: 2010
    ..on the cell surface, the secretome, and serum from mouse models and humans;the use of biologically targeted quantum dots for molecular imaging of living subjects;and mouse models for integrating ex vivo tissue/serum protein patterns ..
  32. Quantum Dot-based Qualitative and Quantitative Multiplex Strip Test for Malaria I
    Y Andrew Wang; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Our goal is to develop easy to use, inexpensive, and sensitive quantum dots beads (QDBs) based strip test for multiplex diagnosis of human malaria infection called MAL-QDBTest" that can detect as low ..
  33. Ultrahigh Resolution Optical Barcode
    ROBERT C HAUSHALTER; Fiscal Year: 2011
    ..The two classes of materials currently used for optical multiplexing are fluorescent organic dyes and Quantum Dots but only <100 optical codes are currently available commercially (e.g. from Luminex)...
  34. Novel Nanorods for High Efficiency Medical Imaging Applications
    Christopher J Summers; Fiscal Year: 2011
    ..structures are significantly better than existing micron-sized crystalline phosphors and conventional spherical quantum dots, in terms of spatial resolution, time resolution, and self-absorption...
  35. Repair of large osteoporotic rat calvarial defects with autologous adipose stem c
    Ming Pei; Fiscal Year: 2012
    ..Tracking of ASCs by quantum dots (QDs) labeling will also be performed to confirm the direct role of ASCs during bone regeneration...
  36. Multifunctional nanoparticles for multiplex detection of breast cancer biomarkers
    Y Andrew Wang; Fiscal Year: 2010
    ..Semiconductor nanocrystals also known as quantum dots (QDs) are a new class of biological detection labels, which present a broad range of biomedical applications ..
  37. Imaging signal transduction in the living mouse brain using two-photon microscopy
    Katerina Akassoglou; Fiscal Year: 2012
    ..for in vivo imaging by two-photon microscopy;(3) develop the first pharmacologic tools (biosensor-conjugated Quantum Dots) to deliver biosensors to microglia and macrophages in the brain;and (4) demonstrate dynamic signaling events ..
  38. Neuronal signal transduction in space and time using single quantum dots
    TOTHU Q VU; Fiscal Year: 2013
    ..We have recently shown that fluorescent nanoparticle quantum dots allow real-time, intracellular visualization of individual receptor complexes with nanoscale spatial resolution,..
  39. Tracking stem cells in engineered tissue and organs in vivo and in real time
    Jeremy J Mao; Fiscal Year: 2012
    ..and Regenerative Medicine," we present an enabling technology of tracking stem cells with bioconjugated quantum dots (QDs) by non-destructive and non- invasive imaging, both in vivo and in real time...
  40. Myosin Va and VI Cargo Transport: In Vitro Model Systems
    David M Warshaw; Fiscal Year: 2013
    ..This will be accomplished by monitoring the individual heads that are labeled with different color quantum dots (Qdots) as force is applied to the motor in a combination laser trap-TIRF microscope...
  41. Novel Targeting Ligands for Sub-populations of monocyte-derived cells
    Suzie H Pun; Fiscal Year: 2010
    ..Binding peptides will then be conjugated to quantum dots to serve as cell specific markers and assessed in mixed cell populations and in tissue sections...
  42. A MEMS intracranial pressure device for monitoring brain injuries and disorders
    NIKOLAOS CHRONIS; Fiscal Year: 2010
    ..Each of the two layers contains NIR quantum dots of a unique wavelength...
  43. Integrated Microdevice to Capture and Detect Circulating Tumor Cells
    RICHARD JAMES COTE; Fiscal Year: 2011
    ..from the same three malignancies, and we will also assess the molecular characteristics of the CTC using the Quantum Dots to understand the biological features of these otherwise rare cells (such as existence of putative stem cell ..
  44. DNA damage induced structural and dynamic changes at telomeres
    Hong Wang; Fiscal Year: 2013
    ..In AFM studies, loading of POT1 (marked by quantum dots, QDs) onto duplex telomeric DMA will be used as a reporter of shelterin assembly...
  45. Human Immunology Center at the University of Rochester
    Tim Mosmann; Fiscal Year: 2012
    ..g. in influenza outbreaks. Second, Quantum dots with excellent potential for flow cytometry and in vivo microscopy will be developed...
  46. Next-Generation Quantum Dots for Molecular and Cellular Imaging of Cancer
    Andrew Michael Smith; Fiscal Year: 2011
    ..We will focus on semiconductor quantum dots (QDs), which are nanocrystals that exhibit bright fluorescence and unique optical and electronic properties...
  47. Murine Circulating Endothelial Precursors (CEPs) and Lung Capillary Repair
    ROSEMARY CRISTIAN JONES; Fiscal Year: 2012
    ..State-of-the-art high resolution and fluorescence imaging approaches (using immunogold labels and quantum dots), and other quantitative approaches, i.e., flow cytometry analyses, will be used...
  48. Application of QDs-based nanotyping technology in the evaluation of chemotherapy
    Y Andrew Wang; Fiscal Year: 2010
    ..b>Quantum dots (QD) are a new class of biological detection labels which present a broad range of biomedical applications...
  49. Rapid parallel 3D confocal/fluorescence cell imaging with varifocal lens
    Guoqiang Li; Fiscal Year: 2010
    ..g.,-opioid receptor) that are incubated with quantum dots coated ligand and we will also study uptake and intracellular distribution of antiviral compounds into human ..
  50. Monovalent Nanocrystals for Biomedical Imaging
    Xiaogang Peng; Fiscal Year: 2010
    ..applicant): Methodology is proposed to develop efficient and general procedures for the synthesis of nontoxic quantum dots, and for conjugating, or 'tagging'these dots to proteins, for the purpose of enhancing and improving ..
  51. Linking the physical and chemical characteristics of Qdots to their toxicity
    TERRANCE JAMES KAVANAGH; Fiscal Year: 2013
    ..One important class of ENMs are quantum dots (Qdots) which are luminescent semiconductor nanocrystals composed of heavy metal cores (e.g...
  52. Next-Generation Quantum Dots for Molecular and Cellular Imaging of Cancer
    Andrew Michael Smith; Fiscal Year: 2013
    ..We will focus on semiconductor quantum dots (QDs), which are nanocrystals that exhibit bright fluorescence and unique optical and electronic properties...
  53. Multi-Laser Flow Cytometer for Polychromatic Analysis
    James E Crowe; Fiscal Year: 2010
    ..First, many of the scientists in the user group have expanded their use of new fluorophores, quantum dots, and variant GFP molecules in an effort to intensify the polychromatic nature of the work, which is needed for ..
  54. TAS::75 0849::TAS R&D-OTHER SCIENCES-B RES
    Patrick McDonough; Fiscal Year: 2011
    ..will feature hapten-coupled primary antibodies to HER2/neu, ER, and PR, and secondary reagents conjugated to quantum dots (ODoIS), which never photo bleach...
  55. TAS::75 0849::TAS R&D-OTHER SCIENCES-B RES
    Patrick McDonough; Fiscal Year: 2010
    ..will feature hapten-coupled primary antibodies to HER2/neu, ER, and PR, and secondary reagents conjugated to quantum dots (ODoIS), which never photo bleach...
  56. Pb-Qdot Direct Gamma Detectors
    IRVING WEINBERG; Fiscal Year: 2013
    ..This separation was accomplished by creating a matrix in which quantum dots made of high-atomic- number material (i.e., lead sulfide) were interspersed within a silicon matrix...
  57. Proximity between immune receptors on the cell surface and the sensitivity of Tce
    Yuri Sykulev; Fiscal Year: 2010
    ..We have recently simulated MHC clusters with a novel tool, semiconductor nanoparticles, quantum dots (QD), bearing controlled numbers of pMHC complexes, and found that the cognate and non-cognate pMHC complexes ..
  58. Validation of the use of quantum dot-labeled proteins as biomarkers in vivo
    Christopher S von Bartheld; Fiscal Year: 2011
    ..Currently, there is great enthusiasm and expectations for the use of quantum dots (QDs), because they have bright fluorescence, differential spectra, superb resolution, and they are electron ..
  59. Probing Tumor Microenvironment Using Nanotechnology
    Rakesh K Jain; Fiscal Year: 2012
    ..Development Cores led by M. Bawendi (an early pioneer of quantum dots) and D. Nocera at MIT are the corner stone of this BRP...
  60. Intracellular delivery and targeting of nanoparticles
    Christine Payne; Fiscal Year: 2009
    ..have recently demonstrated the first method for non-invasive delivery of semiconductor nanoparticles, known as quantum dots (QDs), to the cytosol of multiple cells simultaneously...
  61. Metal-titanates as Novel Inhibitors of Cariogenic Biofilms at Tooth-composite Int
    DANIEL CN CHAN; Fiscal Year: 2013
    ..with respect to tooth/composite restoration interface will be quantified non-invasively by Mab-conjugated quantum dots. There are only three such reports on bacterial biofilms and none applied to cariogenic bacteria...
  62. Molecular Target Variation Across Environments and at Margins of Glioblastoma
    CONSTANTINOS GEORGE HADJIPANAYIS; Fiscal Year: 2013
    ..and phospho-protein profiles, EGFR/PDGFRA amplification and downstream network activation by multiplex quantum dots. We also investigate molecular alterations that evolve within recurrent GBM in patient samples as compared to ..
  63. Northeastern Ohio Animal Imaging Resource Center- NOAIRC
    Jeffrey Duerk; Fiscal Year: 2006
    ..g., quantum dots)...
  64. Targeted Ceramic Nanovectors for Simultaneous Therapy and Imaging of Cancer
    SANDWIP DEY; Fiscal Year: 2009
    ..The core will consist of fluorescent semiconductor quantum dots and silver nanorods for fluorescent and near-infra red (NIR) imaging, respectively...
  65. Quantum Dots and Magnetic Nanoparticles for Ante-mortem Diagnosis of Prion Infect
    ZORAIDA AGUILAR; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): NIH Phase I Quantum dots and Magnetic nano-particles for Ante-mortem Diagnostics of m Prion Infection Ocean Nano Tech proposes to develop a portable, rapid, sensitive, high throughput, inexpensive, ..
  66. Hybrid Nanostructures for Wireless In Vivo Action Potential Sensing
    Joshua Goldberger; Fiscal Year: 2009
    ..Second, the optical properties of quantum dots have numerous demonstrated advantages over the organic dyes that have been typically employed, including orders ..
  67. Nanocrystalline Phosphors for Medical Imaging Applications
    CHRISTOPHER SUMMERS; Fiscal Year: 2009
    A new class of high-performance X-ray phosphor screens will be developed based on nanocrystal quantum dots (QDs), with applications to protein crystallography, digital radiography and mammography applications, as well as a host of other ..
  68. Multiplexed Detection of Bioterror Agents
    Francis Barany; Fiscal Year: 2004
    ..In addition, the LDR/PCR virulence gene test from Aim 2 will be expanded to include the major BT toxin and virulence genes. Once verified, our tests will be validated with clinical samples at the CDC. ..
  69. Use of Bioconjugated Quantum Dots in Micro FlowCytometer
    Joel Tabb; Fiscal Year: 2005
    Fluorescent semiconductor nanocrystals or quantum dots have many properties that make them superior to traditional dyes as fluorescent markers...
  70. Exploratory Study of Carbon-Based Quatum Dots
    Ya Ping Sun; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The special optical properties of nanosized semiconductors (quantum dots) have captured much imagination, promising a variety of applications in biology and medicine...
  71. Multi-Function Laser Scanning Microscope
    David Piston; Fiscal Year: 2009
    ..we have developed in vivo quantitative laser scanning imaging protocols for NAD(P)H, Ca2+ indicator dyes, quantum dots, and GFP mutants, as well as photochemical activation protocols...
  72. Use of nanotechnology to rapidly detect human pathogens
    RICHARD MONTAGNA; Fiscal Year: 2005
    ..probe ("reporter" probe) will be bound to liposome nanovesicles, which in turn, will encapsulate quantum dots (QDots)...
  73. Quantifying Kidney Function with Quantum Dot Nanoprobes
    Weiming Yu; Fiscal Year: 2009
    ..in vivo with unmatched precision by: (1) applying a new generation of semiconductor nanocrystals (CdSe/ZnS quantum dots) as highly accurate size rulers and very sensitive electrostatic nanosensors combined with (2) a recently ..
  74. Portable, rapid and user-friendly diagnostic system for chemical threat exposure
    Xichun Zhou; Fiscal Year: 2006
    ..molecular beacons specific to metabolites of chemical threat agents, as recognition elements, and fluorescent quantum dots as signal output...
  75. Acquisition of Zeiss 710 Confocal Laser Scanning Microscope
    Anastas Popratiloff; Fiscal Year: 2009
    ..Additional laser lines (405nm) will offer labeling detection for state of the art markers such as quantum dots. Proposed instrument will be equipped with environmental control, which in combination of the greatest ..
  76. Quantum Dots for NIR Fluorescence Imaging of Tumor Angiogenesis
    Zhen Cheng; Fiscal Year: 2009
    ..Intermediate objective of this application is to develop cyclic RGD peptide conjugated quantum dots (QDs) for near-infrared (NIR) fluorescence imaging of av[unreadable]3 integrin expression in vivo...
  77. Targeted Near-Infrared Probes for Image-Guided Cancer Interventions
    DIEGO A REY; Fiscal Year: 2010
    ..Aim 1 will comprise the creation of water-soluble NIR quantum dots (QDs) that emit in the wavelength range from 850 to 2200 nm...
  78. Pb-Qdot Direct Gamma Detectors
    IRVING WEINBERG; Fiscal Year: 2009
    ..Nanotechnology can provide confined materials (e.g., quantum dots) with electronic properties that significantly differ from those of the bulk formulations of the same compounds...