implantable infusion pumps

Summary

Summary: Implanted fluid propulsion systems with self-contained power source for providing long-term controlled-rate delivery of drugs such as chemotherapeutic agents or analgesics. Delivery rate may be externally controlled or osmotically or peristatically controlled with the aid of transcutaneous monitoring.

Top Publications

  1. ncbi Implantable closed-loop glucose-sensing and insulin delivery: the future for insulin pump therapy
    Eric Renard
    Department of Endocrinology, Lapeyronie Hospital, 34295, Cedex 5, Montpellier, France
    Curr Opin Pharmacol 2:708-16. 2002
  2. ncbi Placement of baclofen pumps through the foramen magnum and upper cervical spine
    Kristine Dziurzynski
    Department of Neurological Surgery, University of Wisconsin Hospital and Clinics, Madison, WI 53792, USA
    Childs Nerv Syst 22:270-3. 2006
  3. ncbi Intrathecal drug therapy using the Codman Model 3000 Constant Flow Implantable Infusion Pumps: experience with 17 cases
    K D Ethans
    Section of Physical Medicine and Rehabilitation, Department of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Spinal Cord 43:214-8. 2005
  4. ncbi Cyproheptadine for intrathecal baclofen withdrawal
    Jay M Meythaler
    Department of Physical Medicine and Rehabilitation, University of Alabama School of Medicine and the University of Alabama Spain Rehabilitation Center, Birmingham 35249 7330, USA
    Arch Phys Med Rehabil 84:638-42. 2003
  5. ncbi Intrathecal baclofen in tetraplegia of spinal origin: efficacy for upper extremity hypertonia
    A S Burns
    Department of Rehabilitation Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Spinal Cord 39:413-9. 2001
  6. ncbi Closed-loop insulin delivery-the path to physiological glucose control
    G M Steil
    Medtronic MiniMed Department, Sensor R and D, 18000 Devonshire St, Northridge, CA 91325 1219, USA
    Adv Drug Deliv Rev 56:125-44. 2004
  7. ncbi Continuous glucose monitoring and closed-loop systems
    R Hovorka
    Diabetes Modelling Group, Department of Paediatrics, University of Cambridge, Cambridge, UK
    Diabet Med 23:1-12. 2006
  8. ncbi Intrathecal baclofen withdrawal mimicking sepsis
    Louise W Kao
    Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    J Emerg Med 24:423-7. 2003
  9. ncbi Abrupt withdrawal from intrathecal baclofen: recognition and management of a potentially life-threatening syndrome
    Robert J Coffey
    Medtronic Inc, Minneapolis, MN 55432 5604, USA
    Arch Phys Med Rehabil 83:735-41. 2002
  10. ncbi Radioisotopic control for baclofen pump catheter failure
    F Le Breton
    Service de Reeducatien, Neurologique Hopital Robert Ballanger, Aulnay sous Bois, France
    Spinal Cord 39:283-5. 2001

Research Grants

Detail Information

Publications222 found, 100 shown here

  1. ncbi Implantable closed-loop glucose-sensing and insulin delivery: the future for insulin pump therapy
    Eric Renard
    Department of Endocrinology, Lapeyronie Hospital, 34295, Cedex 5, Montpellier, France
    Curr Opin Pharmacol 2:708-16. 2002
    ..Preliminary investigations of intravascular enzymatic sensors demonstrate their clinical acceptability and accuracy and the possibility of developing closed-loop insulin delivery by combination with implantable pumps...
  2. ncbi Placement of baclofen pumps through the foramen magnum and upper cervical spine
    Kristine Dziurzynski
    Department of Neurological Surgery, University of Wisconsin Hospital and Clinics, Madison, WI 53792, USA
    Childs Nerv Syst 22:270-3. 2006
    ..As an alternative to placing the pump catheter through the lumbar spine, we report our experience with placement of the catheter in the spinal canal via a cervical approach through the foramen magnum...
  3. ncbi Intrathecal drug therapy using the Codman Model 3000 Constant Flow Implantable Infusion Pumps: experience with 17 cases
    K D Ethans
    Section of Physical Medicine and Rehabilitation, Department of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Spinal Cord 43:214-8. 2005
    ..The distinctive features of this pump include a raised, easily palpable septum, a safety valve protecting the bolus pathway, no programmer needed, and no battery to fail...
  4. ncbi Cyproheptadine for intrathecal baclofen withdrawal
    Jay M Meythaler
    Department of Physical Medicine and Rehabilitation, University of Alabama School of Medicine and the University of Alabama Spain Rehabilitation Center, Birmingham 35249 7330, USA
    Arch Phys Med Rehabil 84:638-42. 2003
    ..To evaluate the efficacy of cyproheptadine in the management of acute intrathecal baclofen (ITB) withdrawal...
  5. ncbi Intrathecal baclofen in tetraplegia of spinal origin: efficacy for upper extremity hypertonia
    A S Burns
    Department of Rehabilitation Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Spinal Cord 39:413-9. 2001
    ..CONCLUSIONS: Intrathecal baclofen is a safe and effective intervention for treating upper extremity hypertonia of spinal origin. In addition, the level of intrathecal catheter placement is felt to be of importance...
  6. ncbi Closed-loop insulin delivery-the path to physiological glucose control
    G M Steil
    Medtronic MiniMed Department, Sensor R and D, 18000 Devonshire St, Northridge, CA 91325 1219, USA
    Adv Drug Deliv Rev 56:125-44. 2004
    ..Experimental closed-loop data employing intravenous and subcutaneous glucose sensors and implanted and external insulin pumps (Medtronic MiniMed, Northridge CA) are presented...
  7. ncbi Continuous glucose monitoring and closed-loop systems
    R Hovorka
    Diabetes Modelling Group, Department of Paediatrics, University of Cambridge, Cambridge, UK
    Diabet Med 23:1-12. 2006
    ..This has fuelled the development of prototypes of a closed-loop system based on the combination of a continuous monitor, a control algorithm, and an insulin pump...
  8. ncbi Intrathecal baclofen withdrawal mimicking sepsis
    Louise W Kao
    Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    J Emerg Med 24:423-7. 2003
    ..Treatment consists of supportive care, reinstitution of baclofen, benzodiazepines, and diagnosis and eventual repair of intrathecal pump and catheter malfunction...
  9. ncbi Abrupt withdrawal from intrathecal baclofen: recognition and management of a potentially life-threatening syndrome
    Robert J Coffey
    Medtronic Inc, Minneapolis, MN 55432 5604, USA
    Arch Phys Med Rehabil 83:735-41. 2002
    ....
  10. ncbi Radioisotopic control for baclofen pump catheter failure
    F Le Breton
    Service de Reeducatien, Neurologique Hopital Robert Ballanger, Aulnay sous Bois, France
    Spinal Cord 39:283-5. 2001
    ..When catheter disconnection, kink, or dislodgement is not visible on X-ray, radioisotopic control is a safe and reliable method for assessment...
  11. ncbi Extra corporeal shock wave lithotripsy of calculi located in lower calyx of left kidney in a spinal cord injury patient who has implantation of baclofen pump in the ipsilateral loin
    S Vaidyanathan
    Spinal Cord 40:94-5. 2002
  12. ncbi Intrathecal antispastic drug application with implantable pumps: results of a 10 year follow-up study
    A Koulousakis
    Department of Neurosurgery, Cologne University, Cologne, Germany
    Acta Neurochir Suppl 97:181-4. 2007
    ..Destructive procedures such as myelotomy are no longer performed in our department in order to treat spasticity...
  13. ncbi [Intrathecal baclofen in severe spasticity due to multiple sclerosis]
    Jarosław Sławek
    Kliniki Neurochirurgii Akademii Medycznej w Gdańsku
    Neurol Neurochir Pol 37:1135-42; discussion 1143. 2003
    ..At a 6-month follow-up the effect was stable--she was able to walk a long distance outdoors with the aid of a crutch. The daily dose of the drug is 500 micrograms. No side effects of complications were noted...
  14. ncbi Intrathecal baclofen therapy in patients with severe spasticity
    G A Marra
    IRCCS Centro Neurolesi Bonino Pulejo, Messina, Italy
    Acta Neurochir Suppl 97:173-80. 2007
    ..These treatments, do not resolve spasticity in about 33% of cases. In these severe cases, more invasive procedures such as muscle infiltrations with botulin toxin and intrathecal baclofen infusion can be used...
  15. ncbi Treatment of spasticity with intrathecal Baclofen administration: long-term follow-up, review of 40 patients
    R Plassat
    Department of Physical Medicine and Rehabilitation, CHU Angers, France
    Spinal Cord 42:686-93. 2004
    ..Case series of a consecutive sample. Retrospective audit...
  16. ncbi Comparison of Tc99m-DTPA and indium-111 DTPA studies of baclofen pump function
    Martin O'Connell
    Division of Nuclear Medicine, Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Clin Nucl Med 29:578-80. 2004
  17. ncbi The use of intrathecal baclofen pump implants in children and adolescents: safety and complications in 200 consecutive cases
    Francesco Motta
    Department of Paediatric Orthopaedics, V Buzzi Children s Hospital, Milan, Italy
    J Neurosurg 107:32-5. 2007
    ..The authors investigated the efficacy of intrathecal baclofen therapy, analyzing the complications and risk factors in 200 consecutive patients who received pump implants...
  18. ncbi Inflammatory mass of an intrathecal catheter in patients receiving baclofen as a sole agent: a report of two cases and a review of the identification and treatment of the complication
    Timothy R Deer
    The Center for Pain Relief, Charleston, West Virginia and Department of Anesthesiologoy, West Virginia University, Charleston, West Virginia 25301, USA
    Pain Med 8:259-62. 2007
    ..Intrathecal baclofen has been used to treat spasticity secondary to stroke, multiple sclerosis, cerebral palsy, spinal cord injury, and other neurological disease...
  19. ncbi Implantable baclofen pump as an adjuvant in treatment of pressure sores
    Sarah A Mess
    Division of Plastic Surgery, Georgetown University Hospital, Washington, DC 2002, USA
    Ann Plast Surg 51:465-7. 2003
    ..Case reports of intrathecal baclofen used in patients with pressure sores demonstrate the use of intrathecal baclofen to improve reconstructive outcomes in spastic patients...
  20. ncbi Functional effects of spinal baclofen
    Hermann Muller
    Dpt Anesthesiology, Intensive Care and Pain Therapy, Kemperhof Hospital, Koblenz, Germany
    Przegl Lek 64:1-2. 2007
  21. ncbi Intrathecal baclofen for the treatment of spasticity
    I Dones
    Department of Neurosurgery, Instituto Nazionale Neurologico C Besta, Via Celoria, Milano, Italy
    Acta Neurochir Suppl 97:185-8. 2007
    ..Currently, treatment of spasticity with ITB is the most effective way of reducing spasticity regardless of its cause...
  22. ncbi [Intrathecal baclofen for treatment of spasticity in patient with cerebral palsy--a preliminary report]
    Marek Jozwiak
    Klinika Ortopedii Dzieciecej, Akademia Medyczna im Karola Marcinkowskiego w Poznaniu
    Chir Narzadow Ruchu Ortop Pol 68:253-9. 2003
    ..Early results of spasticity treatment in cerebral palsy with intrathecal baclofen infusions are very promising...
  23. ncbi Infusion of intrathecal baclofen for acute withdrawal. Technical note
    Bradley S Duhon
    Department of Neurosurgery, University of Utah, Salt Lake City, Utah 84132, USA
    J Neurosurg 107:878-80. 2007
    ..In both cases, the patients recovered to their neurological baseline level, and lasting consequences of serious withdrawal were avoided...
  24. ncbi Surgical management of spasticity of cerebral origin in children
    S Sgouros
    Department of Neurosurgery, Birmingham Children s Hospital, Birmingham, UK
    Acta Neurochir Suppl 97:193-203. 2007
    ..Current pumps have practical limitations but, in the next decade, it is anticipated that technological improvements will render the pumps more patient friendly...
  25. ncbi Opisthotonus and intrathecal treatment with baclofen (ITB) in children
    Berten Ceulemans
    Rehabilitation and Epilepsy Centre for Children and Youth, Reebergenlaan 4, B 2242 Pulderbos, Belgium
    Eur J Pediatr 167:641-5. 2008
    ..This increase in weight might be due to a reduction in energy expenditure as a result of the decrease in spasticity. Intrathecal treatment with baclofen should be considered in every child with opisthotonus...
  26. ncbi Baclofen toxicity in an 8-year-old with an intrathecal baclofen pump
    Ronald N Yeh
    Department of Emergency Medicine, University of Michigan, Ann Arbor, Michigan, USA
    J Emerg Med 26:163-7. 2004
    ..This report describes the clinical presentation, unfamiliar dilemmas, and the management of a pediatric patient with intrathecal baclofen toxicity, noting problems that may arise in the care of these patients...
  27. ncbi Intrathecal baclofen for spasticity-related pain in amyotrophic lateral sclerosis: efficacy and factors associated with pain relief
    Shearwood McClelland
    Department of Neurosurgery, University of Minnesota Medical School, Mayo Mail Code 96, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Muscle Nerve 37:396-8. 2008
    ..Postoperative pain reduction was predicted by the degree of pain reduction following preoperative ITB test injection. These results support ITB as a treatment modality for pain associated with spasticity in ALS...
  28. ncbi Interaction of ventriculoperitoneal shunt and baclofen pump
    Daniel H Fulkerson
    Pediatric Neurosurgery Service, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, 702 Barnhill Drive, Room 1134, Indianapolis, IN 46202, USA
    Childs Nerv Syst 23:733-8. 2007
    ..The authors present three cases of children with shunted hydrocephalus and intrathecal delivery of baclofen via an implanted pump. Each case illustrates a potential interaction of these devices...
  29. ncbi Neurophysiologic evaluation of spastic hypertonia: implications for management of the patient with the intrathecal baclofen pump
    Stuart A Yablon
    Center for Neuroscience and Neurological Recovery, Methodist Rehabilitation Center, Jackson, Mississippi 39216, USA
    Am J Phys Med Rehabil 83:S10-8. 2004
    ....
  30. pmc Long term effect (more than five years) of intrathecal baclofen on impairment, disability, and quality of life in patients with severe spasticity of spinal origin
    A Zahavi
    Department of Rehabilitation, University Groningen, Netherlands
    J Neurol Neurosurg Psychiatry 75:1553-7. 2004
    ..To evaluate long term change in impairment, disability, and health related functional status in patients with severe spasticity who received intrathecal baclofen...
  31. ncbi Long-term intrathecal baclofen therapy in ambulatory patients with spasticity
    Saud A Sadiq
    MS Research and Treatment Center of New York, Albert Einstein College of Medicine, 425 West 59th Street, Suite 7C, New York, NY 10019, USA
    J Neurol 253:563-9. 2006
    ..This retrospective study is designed to determine the long-term ambulatory function in patients receiving ITB...
  32. pmc Baclofen pump intervention for spasticity affecting pulmonary function
    Deanna Britton
    Speech Language Pathology Clinical Specialist, Harborview Medical Center, 325 Ninth Avenue, Box 359819, Seattle, WA 98104, USA
    J Spinal Cord Med 28:343-7. 2005
    ..This study presents the case of a man with C4 tetraplegia who had severe spasticity and difficulty weaning from ventilatory support...
  33. ncbi [Treatment of severe spacticity in multiple sclerosis by continuous intrathecal baclofen]
    Predrag Peric
    Vojnomedicinska akademija, Klinika za neurohirurgiju, Beograd, Srbija i Crna Gora
    Vojnosanit Pregl 63:187-91. 2006
    ..Continuous intrathecal administration of baclofen (ITB), using a subcutaneously implanted programmable infusion pump, is a minimally invasive, reversible method for the treatment of severe diffuse spasticity of the spinal origin...
  34. ncbi Continuous intrathecal baclofen administration by a fully implantable electronic pump for severe spasticity treatment: our experience
    A Guglielmino
    Anesthesia and Intensive Care Unit, Polyclinic University Hospital of Catania, Catania, Italy
    Minerva Anestesiol 72:807-20. 2006
    ....
  35. ncbi Best-practice surgical techniques for intrathecal baclofen therapy
    A Leland Albright
    Department of Neurosurgery, University of Pittsburgh, Pennsylvania, USA
    J Neurosurg 104:233-9. 2006
    ..Panel members advocate the aforementioned techniques to improve the efficacy of and decrease the morbidity associated with ITB therapy...
  36. ncbi Dose-response relationship between the H-reflex and continuous intrathecal baclofen administration for management of spasticity
    Dobrivoje S Stokic
    Center for Neuroscience and Neurological Recovery, Jackson, MS 39216, USA
    Clin Neurophysiol 117:1283-9. 2006
    ..To determine the relationship between the H-reflex (H/M ratio) and continuous intrathecal baclofen (CITB) dose after pump implantation for control of spastic hypertonia...
  37. ncbi Intrathecal baclofen therapy: ten steps toward best practice
    Barbara Ridley
    Alta Bates Summit Medical Center, Berkeley, CA, USA
    J Neurosci Nurs 38:72-82. 2006
    ....
  38. ncbi Intrathecal baclofen in the treatment of adult spasticity
    Joseph C Hsieh
    Section of Neurosurgery, University of Chicago, Illinois 60637, USA
    Neurosurg Focus 21:e5. 2006
    ..In this paper the authors survey the use of oral and intrathecal baclofen therapy, detail the surgical process, and explain the risks and benefits of the procedure...
  39. ncbi A clinical study of intrathecal baclofen using a programmable pump for intractable spasticity
    Daniel Guillaume
    Centre Neurologique et de Réadaptation Fonctionnelle, Fraiture en Condroz, Belgium
    Arch Phys Med Rehabil 86:2165-71. 2005
    ..To determine the impact of intrathecal baclofen (ITB) therapy on outcomes of functional independence, pain, subjective improvement, performance, and standard measures of spasticity...
  40. ncbi Performance and complications associated with the synchromed 10-ml infusion pump for intrathecal baclofen administration in children
    A Leland Albright
    Department of Pediatric Neurosurgery, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Neurosurg 101:64-8. 2004
    ....
  41. ncbi Salvage of baclofen pump pocket infection with muscle flap
    Bishara S Atiyeh
    Plast Reconstr Surg 114:1661-3. 2004
  42. ncbi Epilepsy and intrathecal baclofen therapy in children with cerebral palsy
    Vincenzo Buonaguro
    Department of Paediatric Orthopedics, Children s Hospital V Buzzi, Milan, Italy
    Pediatr Neurol 33:110-3. 2005
    ..We conclude that in children with spasticity of cerebral origin, intrathecal baclofen does not seem to aggravate or induce seizure activity...
  43. ncbi [Management of increase in spasticity in patients with intrathecal baclofen pumps]
    N Roche
    Service de médecine physique et réadaptation, Hopital Raymond Poincare, APHP, Universite de Versailles Saint Quentin, 104, Boulevard Raymond Poincare, 92380 Garches, France
    Ann Readapt Med Phys 50:93-9. 2007
    ..Diagnosis of these complications can be difficult. A diagnostic tree would be a useful tool in cases of suspected malfunctioning of the intrathecal bacolfen infusion system and would standardise the diagnostic procedure...
  44. ncbi Quality of life of patients with telemetric pumps for intrathecal baclofen infusion: data and limitations of assessment scales
    Placido Bramanti
    Centro Studi Neurolesi, University of Messina, Italy
    Funct Neurol 19:227-31. 2004
    ..These results encourage us to continue this study in a larger patient sample, considering different types of pathology and presence/absence of caregivers...
  45. ncbi Dosage of intrathecal baclofen maintenance therapy in the spastic syndromes
    Youssef Fares
    Neurosurgical Service, Ntra Sra Clinic of the Conception Jimenez Diaz Foundation, Madrid, Spain
    J Med Liban 52:13-8. 2004
    ..81 microg/day in the final phase. These doses were higher in patients with medullary traumatic lesion, diffuse cerebral lesion and spastic idiopathic paraparesis. Relatively mild side effects were produced by the therapeutic doses used...
  46. ncbi Intrathecal baclofen for muscle spasticity and pain--two case reports
    Dhafir Al Khudhairi
    Sultan Bin Abdelaziz Humanitarian Centre and Riyadh Armed Forces Hospital, Saudi Arabia
    Middle East J Anesthesiol 18:971-6. 2006
  47. ncbi GMFM 1 year after continuous intrathecal baclofen infusion
    Linda E Krach
    Pediatric Rehabilitation Medicine at Gillette Children s Specialty Healthcare, St Paul, MN, USA
    Pediatr Rehabil 8:207-13. 2005
    ..05) in Ashworth scores in CP classes 2-5. Subjects or their caregivers that completed a survey about perceived changes stated that motor control, positioning and endurance improved...
  48. ncbi Intrathecal baclofen therapy in children
    A Leland Albright
    Department of Neurosurgery, University of Wisconsin School of Medicine, Madison, Wisconsin 53792, USA
    Neurosurg Focus 21:e3. 2006
    ..Additional investigation is needed to determine the effects of ITB on other movement disorders such as athetosis and chorea...
  49. ncbi Time course of the effect of a bolus dose of intrathecal baclofen on severe cerebral spasticity
    Marcus Pohl
    Dept of Neurological Rehabilitation, Klinik Bavaria, An der Wolfsschlucht 1 2, 01731 Kreischa, Germany
    J Neurol 250:1195-200. 2003
    ..5 hours, with a maximal effect at 4 hours after intrathecal baclofen injection. Clinical scales used to determine the effect of BBT should thus be carried out during this period-ideally at 4 hours after baclofen injection...
  50. ncbi [Baclofen dose in a screening test and in a baclofen pump filling--is there any differences]
    Przemysław Grzegorzewski
    Oddział Neurochirurgii, Pracownia Neurorehabilitacji, Uniwersytecki Szpital Dzieciecy w Krakowie
    Przegl Lek 64:8-12. 2007
    ..In this study we compared a bolus intrathecal injection given in a screening test with doses uses for filling a baclofen pump. In selected group we observed increased Baclofen dose due to dose given in screening test...
  51. ncbi Subfascial implantation of intrathecal baclofen pumps in children: technical note
    B H Kopell
    Department of Neurosurgery, New York University School of Medicine, New York 10016, USA
    Neurosurgery 49:753-6; discussion 756-7. 2001
    ..CONCLUSION: At this early follow-up, the subfascial implantation technique was associated with a reduced rate of local wound and pump infections and provided optimal cosmetic results as compared with that observed in retrospective cases...
  52. ncbi Intrathecal baclofen for spasticity caused by thrombotic stroke
    B L Gwartz
    Pain Diagnosis and Treatment, Inc, Glendora, CA 91741-4205, USA
    Am J Phys Med Rehabil 80:383-7. 2001
    ..The patient achieved substantial functional gains as well as improved ease of care, quality of life, and cessation of narcotic use...
  53. ncbi [Coma induced by an overdose of intrathecal baclofen]
    H Alonso-Navarro
    Rev Neurol 43:63-4. 2006
  54. ncbi Intrathecal baclofen therapy in adults and guideline for clinical nursing care
    Rozina Bhimani
    Sister Kenny Rehabilitation Associates, Abbott Northwestern Hospital, Minneapolis, MN, USA
    Rehabil Nurs 33:110-6. 2008
    ..A fundamental understanding of the intrathecal baclofen pump allows nurses to provide cutting-edge technological and individualized care with compassion...
  55. ncbi Oral motor, communication, and nutritional status of children during intrathecal baclofen therapy: a descriptive pilot study
    Kristie F Bjornson
    Children s Hospital and Regional Medical Center, Neurodevelopmental Clinic, Spasticity Management Clinic, Seattle, WA, USA
    Arch Phys Med Rehabil 84:500-6. 2003
    ..To describe the oral motor, communication, and nutritional status of children receiving intrathecal baclofen (ITB) therapy for spasticity of cerebral origin...
  56. ncbi Intrathecal baclofen therapy in children with cerebral palsy
    Ted R Brown
    Arch Phys Med Rehabil 84:624; author reply 624. 2003
  57. ncbi A review of the complications of intrathecal baclofen in patients with cerebral palsy
    Kat Kolaski
    Department of Orthopaedic Surgery, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    NeuroRehabilitation 22:383-95. 2007
    ..However, until we have consistent, reliable reports of complications, it will not be possible to perform specific risk/benefit analyses. Recommendations for improving investigation in this important area are discussed...
  58. ncbi Intrathecal baclofen for the treatment of spasticity of cerebral origin
    Jennifer Disabato
    Department of Child Neurology, Children s Hospital, Denver, CO, USA
    J Spec Pediatr Nurs 8:31-4. 2003
    ..Close collaboration and communication regarding the child and his/her response to ITB is essential to providing safe and effective care for this challenging population of patients...
  59. ncbi Intrathecal baclofen for spasticity management in Rett syndrome
    Vivek Kadyan
    Department of Physical Medicine and Rehabilitation, The Ohio State University Medical Center, Columbus, USA
    Am J Phys Med Rehabil 82:560-2. 2003
    ..The decrease in spasticity in this patient eventually led to improved range of motion, positioning, skin care, hygiene, and quality of life. Intrathecal baclofen is an effective option in managing severe spasticity from Rett syndrome...
  60. ncbi Intrathecal baclofen withdrawal: a case report and review of the literature
    Tord D Alden
    Department of Neurosurgery, St Louis Children s Hospital, One Children s Place, Suite 4S20, Washington University School of Medicine, MO 63110, USA
    Childs Nerv Syst 18:522-5. 2002
    ..Withdrawal from oral baclofen has been well described. Intrathecal baclofen withdrawal has been less frequently reported. We present a case of withdrawal after intrathecal baclofen pump catheter failure...
  61. ncbi [Assessment of spasticity therapy with baclofen pump in children]
    Anna Swierczyńska
    Pracownia Neurorehabilitacji, Uniwersytecki Szpital Dzieciecy w Krakowie
    Przegl Lek 64:15-7. 2007
    ..The aim of this study was to assess of treatment of spasticity in children with baclofen pump, before and after pump implantation...
  62. ncbi [The parents expectations after baclofen pump implantation in child with severe spasticity in physical rehabilitation and psychological aspects]
    Alicja Fafara
    Oddział Neurochirurgii Uniwersytecki Szpital Dzieciecy w Krakowie
    Przegl Lek 64:18-21. 2007
    ..It results also in improvement of patients and their families quality of life. The aim of study was to assess the effects after baclofen pump implantation due to parents expectations...
  63. ncbi Treatment of spasticity in a spinal cord-injured patient with intrathecal morphine due to intrathecal baclofen tolerance--a case report and review of literature
    B M Soni
    Regional Spinal Injuries Centre, Southport and Ormskirk NHS Trust, Southport, UK
    Spinal Cord 41:586-9. 2003
    ..Case report...
  64. ncbi Improvement in walking speed in poststroke spastic hemiplegia after intrathecal baclofen therapy: a preliminary study
    Gerard E Francisco
    Physical Medicine and Rehabilitation Alliance, Baylor College of Medicine and University of Texas Houston Medical School, Houston, TX, USA
    Arch Phys Med Rehabil 84:1194-9. 2003
    ..To explore whether intrathecal baclofen (ITB) therapy improves ambulation in stroke survivors...
  65. ncbi Combined treatment with BTX-A and ITB for spasticity: case report
    Chandler E Gill
    Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232 2551, USA
    Tenn Med 100:41-2, 44. 2007
    ..Expanded investigations should be carried out to evaluate the efficacy of combined therapy in patients with mental retardation...
  66. ncbi Monitoring of creatinine kinase during weaning of intrathecal baclofen and with symptoms of early withdrawal
    Sam C Colachis
    Department of Physical Medicine and Rehabilitation and SCI Rehabilitation, College of Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    Am J Phys Med Rehabil 82:489-92. 2003
    ....
  67. ncbi Granulocyte-macrophage colony-stimulating factor stimulates arteriogenesis in a pig model of peripheral artery disease using clinically applicable infusion pumps
    Sebastian Grundmann
    Department of Cardiology and Angiology, University Hospital Freiburg, Freiburg, Germany
    J Vasc Surg 43:1263-9. 2006
    ..GM-CSF application in patients with PAD, we hypothesized that intra-arterial cytokine application using implantable infusion pumps might well stimulate arteriogenesis in a large-species model of peripheral vascular disease...
  68. ncbi Chronic MCH-1 receptor modulation alters appetite, body weight and adiposity in rats
    Lauren P Shearman
    Department of Pharmacology, Merck Research Laboratories, PO Box 2000, Building RY80Y 150, Rahway, NJ 07065, USA
    Eur J Pharmacol 475:37-47. 2003
    ..microg/day), Compound B (30 or 48 microg/day) or neuropeptide Y (24 microg/day, as positive control) via implantable infusion pumps. Continuous MCH-1 receptor activation recapitulated the obese phenotype of MCH-over-expressor mice, ..
  69. ncbi Stability and compatibility of hydromorphone hydrochloride in an implantable infusion system
    K R Hildebrand
    Medtronic, Inc, Minneapolis, MN 55432-5604, USA
    J Pain Symptom Manage 22:1042-7. 2001
    ..These results demonstrate that hydromorphone is stable at physiological temperatures for at least 4 months in an implantable infusion system and that current clinical practice of refilling the pump every 3 months is appropriate...
  70. ncbi Arterial chemoinfusion therapy through an implanted port system for patients with unresectable intrahepatic cholangiocarcinoma--initial experience
    Naoshi Tanaka
    Department of Radiology, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Eur J Radiol 41:42-8. 2002
    ..The mean survival period was 26 months. Toxicity such as cholangitis and pancytopenia was found in three patients (27%). This treatment seems to improve the prognosis of patients with unresectable ICC and deserves further studies...
  71. ncbi Drug-eluting stents for the prevention of restenosis: in quest for the Holy Grail
    Bonnie L Hiatt
    Stanford University Medical Center, Stanford, California
    Catheter Cardiovasc Interv 55:409-17. 2002
  72. ncbi Systemically administered human growth hormone improves initial implant stability: an experimental study in the rabbit
    V F Stenport
    Department of Biomaterials Handicap Research, Gothenburg University, Box 412, S 405 30, Gothenburg, Sweden
    Clin Implant Dent Relat Res 3:135-41. 2001
    ..This study was an investigation to determine whether human growth hormone (hGH) continuously administered to rabbits may improve implant integration in bone...
  73. pmc Tolerance, opioid-induced allodynia and withdrawal associated allodynia in infant and young rats
    M H Zissen
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, USA
    Neuroscience 144:247-62. 2007
    ..Furthermore, tolerance, opioid-induced hypersensitivity, and withdrawal-associated hypersensitivity are age-specific and may be mediated by distinct mechanisms...
  74. ncbi Implantable drug delivery systems (IDDS) after failure of comprehensive medical management (CMM) can palliate symptoms in the most refractory cancer pain patients
    Thomas J Smith
    Thomas Palliative Care Unit, Division of Hematology Oncology and Palliative Care, Virginia Commonwealth University, MCV Box 980230, Richmond, VA 23298 0230, USA
    J Palliat Med 8:736-42. 2005
    ..The objective of this study was to evaluate whether IDDS could help the most refractory patients failed by expert CMM...
  75. pmc Infusion of angiotensin-(1-7) reduces glomerulosclerosis through counteracting angiotensin II in experimental glomerulonephritis
    Jiandong Zhang
    Division of Nephrology, Zhongda Hospital, Southeast University School of Medicine, Nanjing, China
    Am J Physiol Renal Physiol 298:F579-88. 2010
    ....
  76. ncbi Accelerated hyperfractionated radiotherapy and concurrent protracted venous infusion chemotherapy in locally advanced head and neck cancer
    Giorgio Arcangeli
    Regina Elena National Cancer Institute, Division of Radiation Oncology, Rome, Italy
    Am J Clin Oncol 25:431-7. 2002
    ..The long-term results of this study suggest that this chemoradiation regimen has the potential of achieving a significant improvement over standard therapy while avoiding significant toxicity...
  77. ncbi Satisfaction of individuals treated long-term with continuous infusion of intrathecal baclofen by implanted programmable pump
    L E Krach
    Pediatric Rehabilitation Medicine, Gillette Children s Specialty Healthcare, St Paul, MN, USA
    Pediatr Rehabil 9:210-8. 2006
    ..To investigate the perspective of the individual receiving intrathecal baclofen (ITB) or his/her caregiver concerning its effects and to describe characteristics of those that were satisfied or not satisfied...
  78. ncbi [Brazilian Diabetes Society consensus statement--intensive insulin therapy and insulin pump therapy]
    Domingos Malerbi
    Sociedade Brasileira de Diabetes
    Arq Bras Endocrinol Metabol 50:125-35. 2006
    ..The conclusions are based on consensual answers to some orienting questions formulated during the symposium's presentation...
  79. ncbi Antiparkinsonian trophic action of glial cell line-derived neurotrophic factor and transforming growth factor β1 is enhanced after co-infusion in rats
    Ramiro Gonzalez-Aparicio
    Departamento de Fisiologia Medica y Biofisica, Universidad de Sevilla, Av Sanchez Pizjuan 4, 41009 Sevilla, Spain
    Exp Neurol 226:136-47. 2010
    ..Functional recovery and improvement of TH signal in the nigrostriatal system were long-lasting and sustained, remaining after cessation of trophic infusion...
  80. ncbi Proteases and protease inhibitors in cerulein-induced acute pancreatitis in rats
    P Kruse
    Department of Pharmacology, Copenhagen University Hospital, Glostrup, Denmark
    J Surg Res 85:294-300. 1999
    ..Proteases and protease inhibitors are important in acute pancreatitis (AP), although little is known about the time course in cerulein-induced AP in the rat...
  81. ncbi Exogenous 25-hydroxycholecalciferol does not attenuate salt-induced hypertension
    M Thierry-Palmer
    Department of Biochemistry, Morehouse School of Medicine, Atlanta, Georgia 30310 1495, USA
    J Steroid Biochem Mol Biol 67:193-9. 1998
    ..These data indicate no ameliorating effect of exogenous 25-hydroxycholecalciferol on salt-induced hypertension, but accelerated metabolism and/or clearance of 25-hydroxycholecalciferol in salt-induced hypertension...
  82. ncbi AM-111 protects against permanent hearing loss from impulse noise trauma
    John K M Coleman
    Naval Medical Center Spatial Orientation Center, 34800 Bob Wilson Dr Suite 200, Naval Medical Center San Diego, San Diego, CA 92134 5000, USA
    Hear Res 226:70-8. 2007
    ..These findings suggest a key role for JNK mediated cochlear sensory cell death from oxidative stress...
  83. ncbi Early chronic blockade of NR2B subunits and transient activation of NMDA receptors modulate LTP in mouse auditory cortex
    Yuting Mao
    Research Center for Brain Science, East China Normal University, Shanghai 200062, China
    Brain Res 1073:131-8. 2006
    ..Blockade from P60 did not result in any decrease of LTP amplitude, suggesting that chronic block in postnatal period may permanently affect cortical circuits so that they cannot produce significant LTP in adulthood...
  84. ncbi Assessment of macrophage infiltration in a murine model of abdominal aortic aneurysm
    Gregory H Turner
    Cardiovascular and Urogenital Center of Excellence for Drug Discovery, GlaxoSmithKline, King of Prussia, Pennsylvania, USA
    J Magn Reson Imaging 30:455-60. 2009
    ..To evaluate the use of an ultrasmall superparamagnetic iron oxide (USPIO) contrast agent as a marker for the detection of macrophage in a preclinical abdominal aortic aneurysm animal (AAA) model...
  85. ncbi Bolus calculator: a review of four "smart" insulin pumps
    Howard Zisser
    Sansum Diabetes Research Institute, Santa Barbara, California 93105, USA
    Diabetes Technol Ther 10:441-4. 2008
    ..It will also include an in silico simulation of a meal followed by a snack using multiple insulin decay curves...
  86. ncbi Remotely adjustable check-valves with an electrochemical release mechanism for implantable biomedical microsystems
    Tingrui Pan
    Department of Biomedical Engineering, UC Davis, USA
    Biomed Microdevices 9:385-94. 2007
    ..Both gravity and syringe-pump driven flow are used to characterize the valve performance. A multi-stage fluidic performance (e.g. flow resistance and opening pressure) is clearly demonstrated...
  87. ncbi [Pharmacological study on levofolinate in intraperitoneal leucovorin-5-FU chemotherapy]
    Michio Maruyama
    Dept of Surgery, Tokyo Metropolitan Ohkubo Hospital
    Gan To Kagaku Ryoho 29:2199-201. 2002
    ..This suggested that intraperitoneal administration elevated the portal vein and abdominal lymphatic levofolinate levels. Intraperitoneal levofolinate-5-FU is a promising protocol for gastro-intestinal cancers...
  88. ncbi [Insulin pump--25 years old and with a future. It counteracts development of late diabetic complications]
    Ulf Adamson
    Medicinska kliniken, enheten för endokrinologi och diabetologi, Danderyds sjukhus, Stockholm
    Lakartidningen 99:5168-70. 2002
  89. ncbi Development of an implantable infusion pump for sustained anti-HIV drug administration
    Lieven Baert
    Chem Pharm Development, Tibotec BVBA, Gen De Wittelaan L11B 3, BE 2800 Mechelen, Belgium
    Int J Pharm 355:38-44. 2008
    ....
  90. ncbi [Cytoreductive surgery with placement of intra-arterial infusion pump for unresectable liver tumors]
    I O Rutkin
    Vopr Onkol 53:206-9. 2007
    ..At present, 8 patients have survived 6-38 months and continue to receive regional chemotherapy; overall 1- or 2- year survival is 85 and 57%, respectively. Six patients died from tumor progression within 4-21 months...
  91. ncbi Interventions in chronic pain management. 6. Interventional approaches to chronic pain management
    E Anthony Overton
    Rothman Institute, Philadelphia, PA 19107, USA
    Arch Phys Med Rehabil 89:S61-4. 2008
    ..The protocol includes hip and spinal injections, neuroablative lesioning, and percutaneous epidural neuroplasty. The second module reviews implantable treatments (spinal cord stimulation, implantable pumps) for intractable pain...
  92. ncbi Role and possible mechanisms of clenbuterol in enhancing reverse remodelling during mechanical unloading in murine heart failure
    Gopal K R Soppa
    Heart Science Centre, Imperial College London, National Heart and Lung Institute, Laboratory of Cellular Electrophysiology, Harefield Hospital, Harefield, Middlesex, UK
    Cardiovasc Res 77:695-706. 2008
    ..Clenbuterol (Clen), a beta(2)-adrenoceptor (beta(2)-AR) agonist, has been used as a part of this strategy. In this study, we investigated the direct effects of clenbuterol on unloaded myocardium in HF...
  93. ncbi Continuous intra-amygdalar infusion of GABA in the amygdala kindling model of epilepsy in rat
    Juan A Barcia
    Servicio de Neurologia, Consorcio Hospital General Universitario de Valencia, Valencia 46014, Spain
    Epilepsy Res 58:19-26. 2004
    ..To explore the effect of continuous intra-amygdalar infusion of GABA in the amygdala kindling model of epilepsy in rat...
  94. ncbi Assessment and management of patients with implanted intrathecal pumps: ED clinical policy sought
    Lorene Newberry
    J Emerg Nurs 30:8. 2004
  95. ncbi Implantable venous port-related infections in cancer patients
    Wen Tsung Huang
    Division of Hematology Oncology, Department of Internal Medicine, National Cheng Kung University Hospital College of Medicine, 138, Sheng Li Rd, Tainan 704, Taiwan, Republic of China
    Support Care Cancer 12:197-201. 2004
    ..To evaluate the characteristics of implantable venous port-related infections in patients with malignancies...
  96. ncbi Continuous intraventricular clonidine infusion in controlled morphine withdrawal--case report
    M Lorenz
    Department of Neurosurgery, Medizinische Hochschule Hannover, Carl Neuberg Str 1, D 30625, Hannover, Germany
    Pain 98:335-8. 2002
    ..Morphine withdrawal with clonidine substitution produced a significant improvement in the analgesic efficacy of morphine and in the quality of life in the absence of undesirable side effects...
  97. ncbi [Intrathecal baclofen therapy]
    Takaomi Taira
    Department of Neurosurgery, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    No Shinkei Geka 36:573-90. 2008
  98. ncbi Mechanical pump dacryoreservoirs
    Juan Murube
    Clinica Murube, Madrid, Spain
    Dev Ophthalmol 41:269-82. 2008
    ..A new option is the implantable pump dacryoreservoir...
  99. ncbi Nicotine dose-concentration relationship and pregnancy outcomes in rat: biologic plausibility and implications for future research
    Jabeen Hussein
    Department of Pediatrics, Health Sciences Center, 3330 Hospital Drive NW, Calgary, Alberta, T2N 4N1, Canada
    Toxicol Appl Pharmacol 218:1-10. 2007
    ..Our current study has major implications for translational research in developmental toxicology and pharmacotherapy using nicotine replacement treatment as an aid to cessation of cigarette smoking in pregnant mothers...
  100. ncbi Morbidity of adjuvant hepatic arterial infusion pump chemotherapy in the management of colorectal cancer metastatic to the liver
    Robert C G Martin
    University of Louisville Department of Surgery, Division of Surgical Oncology, James Brown Cancer Center, 315 E Broadway, Room 313, Louisville, KY 40202, USA
    Am J Surg 188:714-21. 2004
    ..The aim of this study was to examine the survival and toxicity in a single institutional experience with adjuvant HAIP chemotherapy...
  101. ncbi Section on tumors: Young Investigator Award: Local release of carboplatin via an Alzet mini-osmotic pump prolongs survival in a rat brainstem tumor model
    Qingze Wu
    Division of Pediatric Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Clin Neurosurg 51:332-9. 2004

Research Grants55

  1. Pediatric Endocrine/Diabetes Physician Scientists
    William Tamborlane; Fiscal Year: 2005
    ..Dr. James Gavin, former President of the ADA and incoming President of Morehouse School of Medicine, has indicated his interest in linking his school to our program in the recruitment of African American trainees. ..
  2. THERAPY OF HEPATIC METASTASES FROM COLORECTAL CARCINOMA
    Nancy Kemeny; Fiscal Year: 2001
    ..Cryosurgery and newer hepatic arterial therapies are therapeutic modalities that can be used in patients in whom liver resection is impossible. ..
  3. Microinfusion Pump For Animal Functional Brain Mapping
    DANIEL HOLSCHNEIDER; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  4. AN IMPLANTABLE BOLUS INFUSION PUMP FOR THE NEUROSCIENCES
    DANIEL HOLSCHNEIDER; Fiscal Year: 2001
    ....
  5. PET Behavioral Brain Mapping In Freely Moving Animals
    DANIEL HOLSCHNEIDER; Fiscal Year: 2006
    ..Such knowledge may provide the basis of an improved integration of a functional brain anatomy in the context of mental disorders. ..
  6. AN IMPLANTABLE BOLUS INFUSION PUMP FOR THE NEUROSCIENCES
    DANIEL HOLSCHNEIDER; Fiscal Year: 2002
    ....
  7. Characterization of Toxicity with Spinal Opiates
    Tony L Yaksh; Fiscal Year: 2010
    ..The present studies aim to define the mechanisms of granuloma formation and point to specific methods to prevent granuloma formation, which will increase the utility and reduce the risks of this important pain therapy. ..
  8. Nasal Delivery of Naltrexone for Treatment of Alcoholism
    Daniel Wermeling; Fiscal Year: 2006
    ..The long-term goal of this work is to develop and commercialize nasal delivered NTX for the treatment of alcoholism. [unreadable] [unreadable] [unreadable]..
  9. Mitochondrial respiratory uncoupling and the pathogenes*
    William Sivitz; Fiscal Year: 2006
    ..This is mediated by one or more UCP subtype. 4. Altered mitochondrial coupling and consequent changes in mitochondrial ROS formation alter endothelial cell generation of nitric oxide. ..
  10. Pain Mechanisms and the Development of Analgesics
    Tony Yaksh; Fiscal Year: 2006
    ..g. COX2 inhibitors, GABApentin, ziconotide) and failures (NK1 antagonist). [unreadable] [unreadable] [unreadable]..
  11. Neuropathic Pain Modulation by Cannabinoids
    Jianren Mao; Fiscal Year: 2006
    ..A better understanding of cannabinoid actions in neuropathic pain states could open a new avenue to developing novel pharmacological tools for the improved management of often intractable and debilitating neuropathic pain syndromes. ..
  12. Cocaine Dependence and Cognitive Control of Behavior
    Clinton Kilts; Fiscal Year: 2006
    ..The long-term goal of these studies is to develop a novel understanding of the processes related to the acquisition, maintenance and social consequences of cocaine addiction. [unreadable] [unreadable]..
  13. Role of Glutamate in Opiate Tolerance and Sensitization
    KEITH TRUJILLO; Fiscal Year: 2005
    ..abstract_text> ..
  14. Antiepileptogenic & Disease Modifying Effects of AEDs
    Asla Pitkanen; Fiscal Year: 2005
    ..abstract_text> ..
  15. 'Parent-Child Co-Regulation of Pediatric Diabetes'
    Linda Gonder Frederick; Fiscal Year: 2005
    ..abstract_text> ..
  16. Glutamate Signaling and Drug Abuse
    MOHAMMADHOSSEIN GHASEMZADEH; Fiscal Year: 2007
    ....
  17. Neurochemical consequences of drugs in adolescent rats
    Sari Izenwasser; Fiscal Year: 2007
    ....
  18. Nanoscale approaches to allelic silencing in myocardial disease states
    Euan Ashley; Fiscal Year: 2009
    ..This familial condition where the heart grows too thick is the most common cause of sudden death in young people and athletes. ..
  19. OPIOID-INDUCED PAIN SENSITIVITY: CLINICAL DIAGNOSIS AND MANAGEMENT
    Jianren Mao; Fiscal Year: 2010
    ....
  20. An fMRI Study of the Impact of Stress on Drug Addiction
    Clinton D Kilts; Fiscal Year: 2010
    ....
  21. Cocaine behavior: Regulation by k-opioids and serotonin
    Sari Izenwasser; Fiscal Year: 2009
    ..abstract_text> ..
  22. Micro-and nano-mechanical and chemical guidance of neurons
    Christine Schmidt; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  23. Continuous Treatment with Oxalate Changes Renal Physiology and Morphology (DK0750
    Susan Ruth Marengo; Fiscal Year: 2008
    ..The objective is to identify those effects which promote these conditions. Future work will determine the mechanism of these effects with the goal of developing an effective preventative therapy. [unreadable] [unreadable] [unreadable]..
  24. Central Mechanisms of Opiate Reinforcement and Dependence
    George Koob; Fiscal Year: 2008
    ....
  25. Fabrication of Novel Biomimetic Polymers Using Combinatorial Peptide Screening
    Christine Schmidt; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  26. Physiological Studies of Age-Related Hearing Loss
    RICHARD SCHMIEDT; Fiscal Year: 2007
    ..Taken together, the three aims explore the major causes and effects of metabolic presbyacusis and have direct application to future interventions to help restore age-related hearing loss. [unreadable] [unreadable]..
  27. Imaging the Neural Correlates of Genetic Risk for ADHD
    Clinton Kilts; Fiscal Year: 2005
    ..By uniquely defining the impact of the dat1 VNTR polymorphism on DAT, these findings will generate knowledge of how genes confer vulnerability to ADHD and medication nonresponse. ..
  28. Periodontal Disease and Rheumatoid Arthritis
    Michael McCracken; Fiscal Year: 2005
    ..Furthermore, it is hypothesized that among patients with rheumatoid arthritis, an association exists between the rate of progression of inflammatory arthritis and the progression of periodontal disease. ..
  29. K OPIOIDS AND DOPAMINE--MECHANISMS OF STIMULANT ABUSE
    Sari Izenwasser; Fiscal Year: 2001
    ..Hence, the ability to regulate dopaminergic transmission via alterations of the dopamine transporter would be useful in the treatment of such syndromes. ..
  30. RENAL INJURY AND ADAPTATION TO HEME PROTEINS
    Karl Nath; Fiscal Year: 2001
    ..Our proposed application thus continues to pursue the functionality of HO-1, as it utilized a new strategy, transgenic mice, and as it defines a new area of involvement namely, renal inflammation. ..
  31. DEVELOPMENTAL STUDIES OF COCHLEAR MECHANICS
    David Mills; Fiscal Year: 2003
    ..abstract_text> ..
  32. BEHAVIORAL GENETICS--MODELS/MECHANISMS OF SCHIZOPHRENIA
    Clinton Kilts; Fiscal Year: 2002
    ..abstract_text> ..
  33. High Field MRI Scanner for Animal Studies
    Ponnada Narayana; Fiscal Year: 2003
    ..Organizational and financial plans for administering and maintaining the scanner are described. To the best of the PI's knowledge, this will be the only facility of its kind in Houston and the Southwest part of the USA. ..
  34. BRAIN MONOAMINES AND LUTEINIZING HORMONE SECRETION
    William Crowley; Fiscal Year: 2003
    ..abstract_text> ..
  35. PHYSIOLOGY AND PATHOPHYSIOLOGY OF GROWTH HORMONE VARIANT
    Susan Kirk; Fiscal Year: 2003
    ..Research Plan: will measure 1) the impact of GH-V on pituitary GH secretion in rats; 2) signal transduction pathways activated by GH-V; 3) the effect of GH-V on glomerular structure in mice. ..
  36. Oxalate & Crystal Renal Phenotypes: A Microarray Study
    Susan Ruth Marengo; Fiscal Year: 2003
    ..The long term objective of this work is to establish the mechanism of oxalate induced damage in the kidney. ..
  37. Behavioral consequences of drug exposure in adolescents
    Sari Izenwasser; Fiscal Year: 2003
    ....
  38. CLINICAL RESEARCH IN NEURO-ONCOLOGY
    ROY PATCHELL; Fiscal Year: 2004
    ..abstract_text> ..
  39. PAIN EVOKED RELEASE OF AMINO ACIDS AND PROSTANOIDS
    Tony Yaksh; Fiscal Year: 2005
    ....
  40. Cellular Mechanisms of Hyperalgesia and Opioid Tolerance
    Jianren Mao; Fiscal Year: 2005
    ....
  41. Systems for intra-parenchymal therapy delivery
    Raghu Raghavan; Fiscal Year: 2004
    ..abstract_text> ..
  42. STRUCTURE/ACTIVITY STUDIES OF NPY
    Ambikaipakan Balasubramaniam; Fiscal Year: 2001
    ..These analogs will have great significance both in fundamental studies as well as in the development of therapeutic drugs for a variety of conditions including feeding disorders and hypertension. ..
  43. MR Image Analysis in MS: Identification of a Surrogate
    Ponnada Narayana; Fiscal Year: 2002
    ..While the main emphasis is on MS, this system should be readily adaptable to investigate and manage various neurological disorders that require accurate determination of tissue volumes and their temporal change. ..
  44. 3 T Whole Body Magnetic Resonance Scanner
    Ponnada Narayana; Fiscal Year: 2004
    ..Strong institutional commitment and financial plans for operating the scanner, particularly the long-term maintenance, are described. ..
  45. MECHANISMS OF VISUAL PLASTICITY
    ARY RAMOA; Fiscal Year: 2005
    ..A better understanding of these mechanisms should provide specific targets to develop novel therapeutic approaches in the treatment of amblyopia. ..
  46. Glutamate Uptake & the Pathogenesis of Neuropathic Pain
    Jianren Mao; Fiscal Year: 2007
    ..abstract_text> ..
  47. ANGIOTENSIN, LEPTIN, AND THE SYMPATHETIC NERVOUS SYSTEM
    Lisa Cassis; Fiscal Year: 2001
    ....
  48. NEUROBIOLOGY OF PAIN
    Tony Yaksh; Fiscal Year: 2005
    ..The complexity of the problems and the diversity of the training approaches emphasize that the training received by these fellows will provide a broad base of knowledge relevant to wide areas of neurobiology. ..
  49. Spinal Galanin and its Receptors in Pain Processing
    Tony Yaksh; Fiscal Year: 2005
    ..We believe the outcome of these studies will provide direct evidence for the role played by this spinal peptidergic system in pain and point to the development of novel anti-hyperpathic agents. ..
  50. MAGNETIC RESONANCE OF SPINAL CORD INJURY
    Ponnada Narayana; Fiscal Year: 2006
    ..With recent advances in the treatment of SCI, there is a critical need to noninvasively monitor the efficacy of a given treatment. The proposed MRI and fMRI studies greatly aid realize this goal. ..
  51. Angiotensin/Sympathetic Interactions and Blood Pressure
    Lisa Cassis; Fiscal Year: 2004
    ..Moreover, novel interactions between AngII and leptin in the control of blood pressure may relate to hypertension in the obese population. ..
  52. Effect of Diabetes on Bone Integration of Implants
    Michael McCracken; Fiscal Year: 2002
    ..This knowledge may lead to bioengineered materials which will modify and improve bone healing response in diabetic patients who receive implants. ..
  53. MRI of Angiogenesis in Spinal Cord Injury
    Ponnada Narayana; Fiscal Year: 2009
    ..In addition, it is possible to modulate angiogenesis in conjunction with other treatments, such as cellular grafts to further enhance the recovery from SCI. Thus the proposed studies have a very high degree of clinical relevance. ..
  54. SERIAL MAGNETIC RESONANCE IN MULTIPLE SCLEROSIS
    Ponnada Narayana; Fiscal Year: 2002
    ..A further significance of these studies is that they may enable us to follow objectively and quantitatively the efficacy of drugs in the treatment of MS. ..