Genomes and Genes
implantable infusion pumps
Summary: Implanted fluid propulsion systems with self-contained power source for providing long-term controlled-rate delivery of drugs such as chemotherapeutic agents or analgesics. Delivery rate may be externally controlled or osmotically or peristatically controlled with the aid of transcutaneous monitoring.
Publications222 found, 100 shown here
- Implantable closed-loop glucose-sensing and insulin delivery: the future for insulin pump therapyEric Renard
Department of Endocrinology, Lapeyronie Hospital, 34295, Cedex 5, Montpellier, France
Curr Opin Pharmacol 2:708-16. 2002..Preliminary investigations of intravascular enzymatic sensors demonstrate their clinical acceptability and accuracy and the possibility of developing closed-loop insulin delivery by combination with implantable pumps...
- Placement of baclofen pumps through the foramen magnum and upper cervical spineKristine Dziurzynski
Department of Neurological Surgery, University of Wisconsin Hospital and Clinics, Madison, WI 53792, USA
Childs Nerv Syst 22:270-3. 2006..As an alternative to placing the pump catheter through the lumbar spine, we report our experience with placement of the catheter in the spinal canal via a cervical approach through the foramen magnum...
- Intrathecal drug therapy using the Codman Model 3000 Constant Flow Implantable Infusion Pumps: experience with 17 casesK D Ethans
Section of Physical Medicine and Rehabilitation, Department of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
Spinal Cord 43:214-8. 2005..The distinctive features of this pump include a raised, easily palpable septum, a safety valve protecting the bolus pathway, no programmer needed, and no battery to fail...
- Cyproheptadine for intrathecal baclofen withdrawalJay M Meythaler
Department of Physical Medicine and Rehabilitation, University of Alabama School of Medicine and the University of Alabama Spain Rehabilitation Center, Birmingham 35249 7330, USA
Arch Phys Med Rehabil 84:638-42. 2003..To evaluate the efficacy of cyproheptadine in the management of acute intrathecal baclofen (ITB) withdrawal...
- Intrathecal baclofen in tetraplegia of spinal origin: efficacy for upper extremity hypertoniaA S Burns
Department of Rehabilitation Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Spinal Cord 39:413-9. 2001..CONCLUSIONS: Intrathecal baclofen is a safe and effective intervention for treating upper extremity hypertonia of spinal origin. In addition, the level of intrathecal catheter placement is felt to be of importance...
- Closed-loop insulin delivery-the path to physiological glucose controlG M Steil
Medtronic MiniMed Department, Sensor R and D, 18000 Devonshire St, Northridge, CA 91325 1219, USA
Adv Drug Deliv Rev 56:125-44. 2004..Experimental closed-loop data employing intravenous and subcutaneous glucose sensors and implanted and external insulin pumps (Medtronic MiniMed, Northridge CA) are presented...
- Continuous glucose monitoring and closed-loop systemsR Hovorka
Diabetes Modelling Group, Department of Paediatrics, University of Cambridge, Cambridge, UK
Diabet Med 23:1-12. 2006..This has fuelled the development of prototypes of a closed-loop system based on the combination of a continuous monitor, a control algorithm, and an insulin pump...
- Intrathecal baclofen withdrawal mimicking sepsisLouise W Kao
Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
J Emerg Med 24:423-7. 2003..Treatment consists of supportive care, reinstitution of baclofen, benzodiazepines, and diagnosis and eventual repair of intrathecal pump and catheter malfunction...
- Abrupt withdrawal from intrathecal baclofen: recognition and management of a potentially life-threatening syndromeRobert J Coffey
Medtronic Inc, Minneapolis, MN 55432 5604, USA
Arch Phys Med Rehabil 83:735-41. 2002....
- Radioisotopic control for baclofen pump catheter failureF Le Breton
Service de Reeducatien, Neurologique Hopital Robert Ballanger, Aulnay sous Bois, France
Spinal Cord 39:283-5. 2001..When catheter disconnection, kink, or dislodgement is not visible on X-ray, radioisotopic control is a safe and reliable method for assessment...
- Extra corporeal shock wave lithotripsy of calculi located in lower calyx of left kidney in a spinal cord injury patient who has implantation of baclofen pump in the ipsilateral loinS Vaidyanathan
Spinal Cord 40:94-5. 2002
- Intrathecal antispastic drug application with implantable pumps: results of a 10 year follow-up studyA Koulousakis
Department of Neurosurgery, Cologne University, Cologne, Germany
Acta Neurochir Suppl 97:181-4. 2007..Destructive procedures such as myelotomy are no longer performed in our department in order to treat spasticity...
- [Intrathecal baclofen in severe spasticity due to multiple sclerosis]Jarosław Sławek
Kliniki Neurochirurgii Akademii Medycznej w Gdańsku
Neurol Neurochir Pol 37:1135-42; discussion 1143. 2003..At a 6-month follow-up the effect was stable--she was able to walk a long distance outdoors with the aid of a crutch. The daily dose of the drug is 500 micrograms. No side effects of complications were noted...
- Intrathecal baclofen therapy in patients with severe spasticityG A Marra
IRCCS Centro Neurolesi Bonino Pulejo, Messina, Italy
Acta Neurochir Suppl 97:173-80. 2007..These treatments, do not resolve spasticity in about 33% of cases. In these severe cases, more invasive procedures such as muscle infiltrations with botulin toxin and intrathecal baclofen infusion can be used...
- Treatment of spasticity with intrathecal Baclofen administration: long-term follow-up, review of 40 patientsR Plassat
Department of Physical Medicine and Rehabilitation, CHU Angers, France
Spinal Cord 42:686-93. 2004..Case series of a consecutive sample. Retrospective audit...
- Comparison of Tc99m-DTPA and indium-111 DTPA studies of baclofen pump functionMartin O'Connell
Division of Nuclear Medicine, Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710, USA
Clin Nucl Med 29:578-80. 2004
- The use of intrathecal baclofen pump implants in children and adolescents: safety and complications in 200 consecutive casesFrancesco Motta
Department of Paediatric Orthopaedics, V Buzzi Children s Hospital, Milan, Italy
J Neurosurg 107:32-5. 2007..The authors investigated the efficacy of intrathecal baclofen therapy, analyzing the complications and risk factors in 200 consecutive patients who received pump implants...
- Inflammatory mass of an intrathecal catheter in patients receiving baclofen as a sole agent: a report of two cases and a review of the identification and treatment of the complicationTimothy R Deer
The Center for Pain Relief, Charleston, West Virginia and Department of Anesthesiologoy, West Virginia University, Charleston, West Virginia 25301, USA
Pain Med 8:259-62. 2007..Intrathecal baclofen has been used to treat spasticity secondary to stroke, multiple sclerosis, cerebral palsy, spinal cord injury, and other neurological disease...
- Implantable baclofen pump as an adjuvant in treatment of pressure soresSarah A Mess
Division of Plastic Surgery, Georgetown University Hospital, Washington, DC 2002, USA
Ann Plast Surg 51:465-7. 2003..Case reports of intrathecal baclofen used in patients with pressure sores demonstrate the use of intrathecal baclofen to improve reconstructive outcomes in spastic patients...
- Functional effects of spinal baclofenHermann Muller
Dpt Anesthesiology, Intensive Care and Pain Therapy, Kemperhof Hospital, Koblenz, Germany
Przegl Lek 64:1-2. 2007
- Intrathecal baclofen for the treatment of spasticityI Dones
Department of Neurosurgery, Instituto Nazionale Neurologico C Besta, Via Celoria, Milano, Italy
Acta Neurochir Suppl 97:185-8. 2007..Currently, treatment of spasticity with ITB is the most effective way of reducing spasticity regardless of its cause...
- [Intrathecal baclofen for treatment of spasticity in patient with cerebral palsy--a preliminary report]Marek Jozwiak
Klinika Ortopedii Dzieciecej, Akademia Medyczna im Karola Marcinkowskiego w Poznaniu
Chir Narzadow Ruchu Ortop Pol 68:253-9. 2003..Early results of spasticity treatment in cerebral palsy with intrathecal baclofen infusions are very promising...
- Infusion of intrathecal baclofen for acute withdrawal. Technical noteBradley S Duhon
Department of Neurosurgery, University of Utah, Salt Lake City, Utah 84132, USA
J Neurosurg 107:878-80. 2007..In both cases, the patients recovered to their neurological baseline level, and lasting consequences of serious withdrawal were avoided...
- Surgical management of spasticity of cerebral origin in childrenS Sgouros
Department of Neurosurgery, Birmingham Children s Hospital, Birmingham, UK
Acta Neurochir Suppl 97:193-203. 2007..Current pumps have practical limitations but, in the next decade, it is anticipated that technological improvements will render the pumps more patient friendly...
- Opisthotonus and intrathecal treatment with baclofen (ITB) in childrenBerten Ceulemans
Rehabilitation and Epilepsy Centre for Children and Youth, Reebergenlaan 4, B 2242 Pulderbos, Belgium
Eur J Pediatr 167:641-5. 2008..This increase in weight might be due to a reduction in energy expenditure as a result of the decrease in spasticity. Intrathecal treatment with baclofen should be considered in every child with opisthotonus...
- Baclofen toxicity in an 8-year-old with an intrathecal baclofen pumpRonald N Yeh
Department of Emergency Medicine, University of Michigan, Ann Arbor, Michigan, USA
J Emerg Med 26:163-7. 2004..This report describes the clinical presentation, unfamiliar dilemmas, and the management of a pediatric patient with intrathecal baclofen toxicity, noting problems that may arise in the care of these patients...
- Intrathecal baclofen for spasticity-related pain in amyotrophic lateral sclerosis: efficacy and factors associated with pain reliefShearwood McClelland
Department of Neurosurgery, University of Minnesota Medical School, Mayo Mail Code 96, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Muscle Nerve 37:396-8. 2008..Postoperative pain reduction was predicted by the degree of pain reduction following preoperative ITB test injection. These results support ITB as a treatment modality for pain associated with spasticity in ALS...
- Interaction of ventriculoperitoneal shunt and baclofen pumpDaniel H Fulkerson
Pediatric Neurosurgery Service, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, 702 Barnhill Drive, Room 1134, Indianapolis, IN 46202, USA
Childs Nerv Syst 23:733-8. 2007..The authors present three cases of children with shunted hydrocephalus and intrathecal delivery of baclofen via an implanted pump. Each case illustrates a potential interaction of these devices...
- Neurophysiologic evaluation of spastic hypertonia: implications for management of the patient with the intrathecal baclofen pumpStuart A Yablon
Center for Neuroscience and Neurological Recovery, Methodist Rehabilitation Center, Jackson, Mississippi 39216, USA
Am J Phys Med Rehabil 83:S10-8. 2004....
- Long term effect (more than five years) of intrathecal baclofen on impairment, disability, and quality of life in patients with severe spasticity of spinal originA Zahavi
Department of Rehabilitation, University Groningen, Netherlands
J Neurol Neurosurg Psychiatry 75:1553-7. 2004..To evaluate long term change in impairment, disability, and health related functional status in patients with severe spasticity who received intrathecal baclofen...
- Long-term intrathecal baclofen therapy in ambulatory patients with spasticitySaud A Sadiq
MS Research and Treatment Center of New York, Albert Einstein College of Medicine, 425 West 59th Street, Suite 7C, New York, NY 10019, USA
J Neurol 253:563-9. 2006..This retrospective study is designed to determine the long-term ambulatory function in patients receiving ITB...
- Baclofen pump intervention for spasticity affecting pulmonary functionDeanna Britton
Speech Language Pathology Clinical Specialist, Harborview Medical Center, 325 Ninth Avenue, Box 359819, Seattle, WA 98104, USA
J Spinal Cord Med 28:343-7. 2005..This study presents the case of a man with C4 tetraplegia who had severe spasticity and difficulty weaning from ventilatory support...
- [Treatment of severe spacticity in multiple sclerosis by continuous intrathecal baclofen]Predrag Peric
Vojnomedicinska akademija, Klinika za neurohirurgiju, Beograd, Srbija i Crna Gora
Vojnosanit Pregl 63:187-91. 2006..Continuous intrathecal administration of baclofen (ITB), using a subcutaneously implanted programmable infusion pump, is a minimally invasive, reversible method for the treatment of severe diffuse spasticity of the spinal origin...
- Continuous intrathecal baclofen administration by a fully implantable electronic pump for severe spasticity treatment: our experienceA Guglielmino
Anesthesia and Intensive Care Unit, Polyclinic University Hospital of Catania, Catania, Italy
Minerva Anestesiol 72:807-20. 2006....
- Best-practice surgical techniques for intrathecal baclofen therapyA Leland Albright
Department of Neurosurgery, University of Pittsburgh, Pennsylvania, USA
J Neurosurg 104:233-9. 2006..Panel members advocate the aforementioned techniques to improve the efficacy of and decrease the morbidity associated with ITB therapy...
- Dose-response relationship between the H-reflex and continuous intrathecal baclofen administration for management of spasticityDobrivoje S Stokic
Center for Neuroscience and Neurological Recovery, Jackson, MS 39216, USA
Clin Neurophysiol 117:1283-9. 2006..To determine the relationship between the H-reflex (H/M ratio) and continuous intrathecal baclofen (CITB) dose after pump implantation for control of spastic hypertonia...
- Intrathecal baclofen therapy: ten steps toward best practiceBarbara Ridley
Alta Bates Summit Medical Center, Berkeley, CA, USA
J Neurosci Nurs 38:72-82. 2006....
- Intrathecal baclofen in the treatment of adult spasticityJoseph C Hsieh
Section of Neurosurgery, University of Chicago, Illinois 60637, USA
Neurosurg Focus 21:e5. 2006..In this paper the authors survey the use of oral and intrathecal baclofen therapy, detail the surgical process, and explain the risks and benefits of the procedure...
- A clinical study of intrathecal baclofen using a programmable pump for intractable spasticityDaniel Guillaume
Centre Neurologique et de Réadaptation Fonctionnelle, Fraiture en Condroz, Belgium
Arch Phys Med Rehabil 86:2165-71. 2005..To determine the impact of intrathecal baclofen (ITB) therapy on outcomes of functional independence, pain, subjective improvement, performance, and standard measures of spasticity...
- Performance and complications associated with the synchromed 10-ml infusion pump for intrathecal baclofen administration in childrenA Leland Albright
Department of Pediatric Neurosurgery, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Neurosurg 101:64-8. 2004....
- Salvage of baclofen pump pocket infection with muscle flapBishara S Atiyeh
Plast Reconstr Surg 114:1661-3. 2004
- Epilepsy and intrathecal baclofen therapy in children with cerebral palsyVincenzo Buonaguro
Department of Paediatric Orthopedics, Children s Hospital V Buzzi, Milan, Italy
Pediatr Neurol 33:110-3. 2005..We conclude that in children with spasticity of cerebral origin, intrathecal baclofen does not seem to aggravate or induce seizure activity...
- [Management of increase in spasticity in patients with intrathecal baclofen pumps]N Roche
Service de médecine physique et réadaptation, Hopital Raymond Poincare, APHP, Universite de Versailles Saint Quentin, 104, Boulevard Raymond Poincare, 92380 Garches, France
Ann Readapt Med Phys 50:93-9. 2007..Diagnosis of these complications can be difficult. A diagnostic tree would be a useful tool in cases of suspected malfunctioning of the intrathecal bacolfen infusion system and would standardise the diagnostic procedure...
- Quality of life of patients with telemetric pumps for intrathecal baclofen infusion: data and limitations of assessment scalesPlacido Bramanti
Centro Studi Neurolesi, University of Messina, Italy
Funct Neurol 19:227-31. 2004..These results encourage us to continue this study in a larger patient sample, considering different types of pathology and presence/absence of caregivers...
- Dosage of intrathecal baclofen maintenance therapy in the spastic syndromesYoussef Fares
Neurosurgical Service, Ntra Sra Clinic of the Conception Jimenez Diaz Foundation, Madrid, Spain
J Med Liban 52:13-8. 2004..81 microg/day in the final phase. These doses were higher in patients with medullary traumatic lesion, diffuse cerebral lesion and spastic idiopathic paraparesis. Relatively mild side effects were produced by the therapeutic doses used...
- Intrathecal baclofen for muscle spasticity and pain--two case reportsDhafir Al Khudhairi
Sultan Bin Abdelaziz Humanitarian Centre and Riyadh Armed Forces Hospital, Saudi Arabia
Middle East J Anesthesiol 18:971-6. 2006
- GMFM 1 year after continuous intrathecal baclofen infusionLinda E Krach
Pediatric Rehabilitation Medicine at Gillette Children s Specialty Healthcare, St Paul, MN, USA
Pediatr Rehabil 8:207-13. 2005..05) in Ashworth scores in CP classes 2-5. Subjects or their caregivers that completed a survey about perceived changes stated that motor control, positioning and endurance improved...
- Intrathecal baclofen therapy in childrenA Leland Albright
Department of Neurosurgery, University of Wisconsin School of Medicine, Madison, Wisconsin 53792, USA
Neurosurg Focus 21:e3. 2006..Additional investigation is needed to determine the effects of ITB on other movement disorders such as athetosis and chorea...
- Time course of the effect of a bolus dose of intrathecal baclofen on severe cerebral spasticityMarcus Pohl
Dept of Neurological Rehabilitation, Klinik Bavaria, An der Wolfsschlucht 1 2, 01731 Kreischa, Germany
J Neurol 250:1195-200. 2003..5 hours, with a maximal effect at 4 hours after intrathecal baclofen injection. Clinical scales used to determine the effect of BBT should thus be carried out during this period-ideally at 4 hours after baclofen injection...
- [Baclofen dose in a screening test and in a baclofen pump filling--is there any differences]Przemysław Grzegorzewski
Oddział Neurochirurgii, Pracownia Neurorehabilitacji, Uniwersytecki Szpital Dzieciecy w Krakowie
Przegl Lek 64:8-12. 2007..In this study we compared a bolus intrathecal injection given in a screening test with doses uses for filling a baclofen pump. In selected group we observed increased Baclofen dose due to dose given in screening test...
- Subfascial implantation of intrathecal baclofen pumps in children: technical noteB H Kopell
Department of Neurosurgery, New York University School of Medicine, New York 10016, USA
Neurosurgery 49:753-6; discussion 756-7. 2001..CONCLUSION: At this early follow-up, the subfascial implantation technique was associated with a reduced rate of local wound and pump infections and provided optimal cosmetic results as compared with that observed in retrospective cases...
- Intrathecal baclofen for spasticity caused by thrombotic strokeB L Gwartz
Pain Diagnosis and Treatment, Inc, Glendora, CA 91741-4205, USA
Am J Phys Med Rehabil 80:383-7. 2001..The patient achieved substantial functional gains as well as improved ease of care, quality of life, and cessation of narcotic use...
- [Coma induced by an overdose of intrathecal baclofen]H Alonso-Navarro
Rev Neurol 43:63-4. 2006
- Intrathecal baclofen therapy in adults and guideline for clinical nursing careRozina Bhimani
Sister Kenny Rehabilitation Associates, Abbott Northwestern Hospital, Minneapolis, MN, USA
Rehabil Nurs 33:110-6. 2008..A fundamental understanding of the intrathecal baclofen pump allows nurses to provide cutting-edge technological and individualized care with compassion...
- Oral motor, communication, and nutritional status of children during intrathecal baclofen therapy: a descriptive pilot studyKristie F Bjornson
Children s Hospital and Regional Medical Center, Neurodevelopmental Clinic, Spasticity Management Clinic, Seattle, WA, USA
Arch Phys Med Rehabil 84:500-6. 2003..To describe the oral motor, communication, and nutritional status of children receiving intrathecal baclofen (ITB) therapy for spasticity of cerebral origin...
- Intrathecal baclofen therapy in children with cerebral palsyTed R Brown
Arch Phys Med Rehabil 84:624; author reply 624. 2003
- A review of the complications of intrathecal baclofen in patients with cerebral palsyKat Kolaski
Department of Orthopaedic Surgery, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
NeuroRehabilitation 22:383-95. 2007..However, until we have consistent, reliable reports of complications, it will not be possible to perform specific risk/benefit analyses. Recommendations for improving investigation in this important area are discussed...
- Intrathecal baclofen for the treatment of spasticity of cerebral originJennifer Disabato
Department of Child Neurology, Children s Hospital, Denver, CO, USA
J Spec Pediatr Nurs 8:31-4. 2003..Close collaboration and communication regarding the child and his/her response to ITB is essential to providing safe and effective care for this challenging population of patients...
- Intrathecal baclofen for spasticity management in Rett syndromeVivek Kadyan
Department of Physical Medicine and Rehabilitation, The Ohio State University Medical Center, Columbus, USA
Am J Phys Med Rehabil 82:560-2. 2003..The decrease in spasticity in this patient eventually led to improved range of motion, positioning, skin care, hygiene, and quality of life. Intrathecal baclofen is an effective option in managing severe spasticity from Rett syndrome...
- Intrathecal baclofen withdrawal: a case report and review of the literatureTord D Alden
Department of Neurosurgery, St Louis Children s Hospital, One Children s Place, Suite 4S20, Washington University School of Medicine, MO 63110, USA
Childs Nerv Syst 18:522-5. 2002..Withdrawal from oral baclofen has been well described. Intrathecal baclofen withdrawal has been less frequently reported. We present a case of withdrawal after intrathecal baclofen pump catheter failure...
- [Assessment of spasticity therapy with baclofen pump in children]Anna Swierczyńska
Pracownia Neurorehabilitacji, Uniwersytecki Szpital Dzieciecy w Krakowie
Przegl Lek 64:15-7. 2007..The aim of this study was to assess of treatment of spasticity in children with baclofen pump, before and after pump implantation...
- [The parents expectations after baclofen pump implantation in child with severe spasticity in physical rehabilitation and psychological aspects]Alicja Fafara
Oddział Neurochirurgii Uniwersytecki Szpital Dzieciecy w Krakowie
Przegl Lek 64:18-21. 2007..It results also in improvement of patients and their families quality of life. The aim of study was to assess the effects after baclofen pump implantation due to parents expectations...
- Treatment of spasticity in a spinal cord-injured patient with intrathecal morphine due to intrathecal baclofen tolerance--a case report and review of literatureB M Soni
Regional Spinal Injuries Centre, Southport and Ormskirk NHS Trust, Southport, UK
Spinal Cord 41:586-9. 2003..Case report...
- Improvement in walking speed in poststroke spastic hemiplegia after intrathecal baclofen therapy: a preliminary studyGerard E Francisco
Physical Medicine and Rehabilitation Alliance, Baylor College of Medicine and University of Texas Houston Medical School, Houston, TX, USA
Arch Phys Med Rehabil 84:1194-9. 2003..To explore whether intrathecal baclofen (ITB) therapy improves ambulation in stroke survivors...
- Combined treatment with BTX-A and ITB for spasticity: case reportChandler E Gill
Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232 2551, USA
Tenn Med 100:41-2, 44. 2007..Expanded investigations should be carried out to evaluate the efficacy of combined therapy in patients with mental retardation...
- Monitoring of creatinine kinase during weaning of intrathecal baclofen and with symptoms of early withdrawalSam C Colachis
Department of Physical Medicine and Rehabilitation and SCI Rehabilitation, College of Medicine, The Ohio State University, Columbus, Ohio 43210, USA
Am J Phys Med Rehabil 82:489-92. 2003....
- Granulocyte-macrophage colony-stimulating factor stimulates arteriogenesis in a pig model of peripheral artery disease using clinically applicable infusion pumpsSebastian Grundmann
Department of Cardiology and Angiology, University Hospital Freiburg, Freiburg, Germany
J Vasc Surg 43:1263-9. 2006..GM-CSF application in patients with PAD, we hypothesized that intra-arterial cytokine application using implantable infusion pumps might well stimulate arteriogenesis in a large-species model of peripheral vascular disease...
- Chronic MCH-1 receptor modulation alters appetite, body weight and adiposity in ratsLauren P Shearman
Department of Pharmacology, Merck Research Laboratories, PO Box 2000, Building RY80Y 150, Rahway, NJ 07065, USA
Eur J Pharmacol 475:37-47. 2003..microg/day), Compound B (30 or 48 microg/day) or neuropeptide Y (24 microg/day, as positive control) via implantable infusion pumps. Continuous MCH-1 receptor activation recapitulated the obese phenotype of MCH-over-expressor mice, ..
- Stability and compatibility of hydromorphone hydrochloride in an implantable infusion systemK R Hildebrand
Medtronic, Inc, Minneapolis, MN 55432-5604, USA
J Pain Symptom Manage 22:1042-7. 2001..These results demonstrate that hydromorphone is stable at physiological temperatures for at least 4 months in an implantable infusion system and that current clinical practice of refilling the pump every 3 months is appropriate...
- Arterial chemoinfusion therapy through an implanted port system for patients with unresectable intrahepatic cholangiocarcinoma--initial experienceNaoshi Tanaka
Department of Radiology, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
Eur J Radiol 41:42-8. 2002..The mean survival period was 26 months. Toxicity such as cholangitis and pancytopenia was found in three patients (27%). This treatment seems to improve the prognosis of patients with unresectable ICC and deserves further studies...
- Drug-eluting stents for the prevention of restenosis: in quest for the Holy GrailBonnie L Hiatt
Stanford University Medical Center, Stanford, California
Catheter Cardiovasc Interv 55:409-17. 2002
- Systemically administered human growth hormone improves initial implant stability: an experimental study in the rabbitV F Stenport
Department of Biomaterials Handicap Research, Gothenburg University, Box 412, S 405 30, Gothenburg, Sweden
Clin Implant Dent Relat Res 3:135-41. 2001..This study was an investigation to determine whether human growth hormone (hGH) continuously administered to rabbits may improve implant integration in bone...
- Tolerance, opioid-induced allodynia and withdrawal associated allodynia in infant and young ratsM H Zissen
Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, USA
Neuroscience 144:247-62. 2007..Furthermore, tolerance, opioid-induced hypersensitivity, and withdrawal-associated hypersensitivity are age-specific and may be mediated by distinct mechanisms...
- Implantable drug delivery systems (IDDS) after failure of comprehensive medical management (CMM) can palliate symptoms in the most refractory cancer pain patientsThomas J Smith
Thomas Palliative Care Unit, Division of Hematology Oncology and Palliative Care, Virginia Commonwealth University, MCV Box 980230, Richmond, VA 23298 0230, USA
J Palliat Med 8:736-42. 2005..The objective of this study was to evaluate whether IDDS could help the most refractory patients failed by expert CMM...
- Infusion of angiotensin-(1-7) reduces glomerulosclerosis through counteracting angiotensin II in experimental glomerulonephritisJiandong Zhang
Division of Nephrology, Zhongda Hospital, Southeast University School of Medicine, Nanjing, China
Am J Physiol Renal Physiol 298:F579-88. 2010....
- Accelerated hyperfractionated radiotherapy and concurrent protracted venous infusion chemotherapy in locally advanced head and neck cancerGiorgio Arcangeli
Regina Elena National Cancer Institute, Division of Radiation Oncology, Rome, Italy
Am J Clin Oncol 25:431-7. 2002..The long-term results of this study suggest that this chemoradiation regimen has the potential of achieving a significant improvement over standard therapy while avoiding significant toxicity...
- Satisfaction of individuals treated long-term with continuous infusion of intrathecal baclofen by implanted programmable pumpL E Krach
Pediatric Rehabilitation Medicine, Gillette Children s Specialty Healthcare, St Paul, MN, USA
Pediatr Rehabil 9:210-8. 2006..To investigate the perspective of the individual receiving intrathecal baclofen (ITB) or his/her caregiver concerning its effects and to describe characteristics of those that were satisfied or not satisfied...
- [Brazilian Diabetes Society consensus statement--intensive insulin therapy and insulin pump therapy]Domingos Malerbi
Sociedade Brasileira de Diabetes
Arq Bras Endocrinol Metabol 50:125-35. 2006..The conclusions are based on consensual answers to some orienting questions formulated during the symposium's presentation...
- Antiparkinsonian trophic action of glial cell line-derived neurotrophic factor and transforming growth factor β1 is enhanced after co-infusion in ratsRamiro Gonzalez-Aparicio
Departamento de Fisiologia Medica y Biofisica, Universidad de Sevilla, Av Sanchez Pizjuan 4, 41009 Sevilla, Spain
Exp Neurol 226:136-47. 2010..Functional recovery and improvement of TH signal in the nigrostriatal system were long-lasting and sustained, remaining after cessation of trophic infusion...
- Proteases and protease inhibitors in cerulein-induced acute pancreatitis in ratsP Kruse
Department of Pharmacology, Copenhagen University Hospital, Glostrup, Denmark
J Surg Res 85:294-300. 1999..Proteases and protease inhibitors are important in acute pancreatitis (AP), although little is known about the time course in cerulein-induced AP in the rat...
- Exogenous 25-hydroxycholecalciferol does not attenuate salt-induced hypertensionM Thierry-Palmer
Department of Biochemistry, Morehouse School of Medicine, Atlanta, Georgia 30310 1495, USA
J Steroid Biochem Mol Biol 67:193-9. 1998..These data indicate no ameliorating effect of exogenous 25-hydroxycholecalciferol on salt-induced hypertension, but accelerated metabolism and/or clearance of 25-hydroxycholecalciferol in salt-induced hypertension...
- AM-111 protects against permanent hearing loss from impulse noise traumaJohn K M Coleman
Naval Medical Center Spatial Orientation Center, 34800 Bob Wilson Dr Suite 200, Naval Medical Center San Diego, San Diego, CA 92134 5000, USA
Hear Res 226:70-8. 2007..These findings suggest a key role for JNK mediated cochlear sensory cell death from oxidative stress...
- Early chronic blockade of NR2B subunits and transient activation of NMDA receptors modulate LTP in mouse auditory cortexYuting Mao
Research Center for Brain Science, East China Normal University, Shanghai 200062, China
Brain Res 1073:131-8. 2006..Blockade from P60 did not result in any decrease of LTP amplitude, suggesting that chronic block in postnatal period may permanently affect cortical circuits so that they cannot produce significant LTP in adulthood...
- Assessment of macrophage infiltration in a murine model of abdominal aortic aneurysmGregory H Turner
Cardiovascular and Urogenital Center of Excellence for Drug Discovery, GlaxoSmithKline, King of Prussia, Pennsylvania, USA
J Magn Reson Imaging 30:455-60. 2009..To evaluate the use of an ultrasmall superparamagnetic iron oxide (USPIO) contrast agent as a marker for the detection of macrophage in a preclinical abdominal aortic aneurysm animal (AAA) model...
- Bolus calculator: a review of four "smart" insulin pumpsHoward Zisser
Sansum Diabetes Research Institute, Santa Barbara, California 93105, USA
Diabetes Technol Ther 10:441-4. 2008..It will also include an in silico simulation of a meal followed by a snack using multiple insulin decay curves...
- Remotely adjustable check-valves with an electrochemical release mechanism for implantable biomedical microsystemsTingrui Pan
Department of Biomedical Engineering, UC Davis, USA
Biomed Microdevices 9:385-94. 2007..Both gravity and syringe-pump driven flow are used to characterize the valve performance. A multi-stage fluidic performance (e.g. flow resistance and opening pressure) is clearly demonstrated...
- [Pharmacological study on levofolinate in intraperitoneal leucovorin-5-FU chemotherapy]Michio Maruyama
Dept of Surgery, Tokyo Metropolitan Ohkubo Hospital
Gan To Kagaku Ryoho 29:2199-201. 2002..This suggested that intraperitoneal administration elevated the portal vein and abdominal lymphatic levofolinate levels. Intraperitoneal levofolinate-5-FU is a promising protocol for gastro-intestinal cancers...
- [Insulin pump--25 years old and with a future. It counteracts development of late diabetic complications]Ulf Adamson
Medicinska kliniken, enheten för endokrinologi och diabetologi, Danderyds sjukhus, Stockholm
Lakartidningen 99:5168-70. 2002
- Development of an implantable infusion pump for sustained anti-HIV drug administrationLieven Baert
Chem Pharm Development, Tibotec BVBA, Gen De Wittelaan L11B 3, BE 2800 Mechelen, Belgium
Int J Pharm 355:38-44. 2008....
- [Cytoreductive surgery with placement of intra-arterial infusion pump for unresectable liver tumors]I O Rutkin
Vopr Onkol 53:206-9. 2007..At present, 8 patients have survived 6-38 months and continue to receive regional chemotherapy; overall 1- or 2- year survival is 85 and 57%, respectively. Six patients died from tumor progression within 4-21 months...
- Interventions in chronic pain management. 6. Interventional approaches to chronic pain managementE Anthony Overton
Rothman Institute, Philadelphia, PA 19107, USA
Arch Phys Med Rehabil 89:S61-4. 2008..The protocol includes hip and spinal injections, neuroablative lesioning, and percutaneous epidural neuroplasty. The second module reviews implantable treatments (spinal cord stimulation, implantable pumps) for intractable pain...
- Role and possible mechanisms of clenbuterol in enhancing reverse remodelling during mechanical unloading in murine heart failureGopal K R Soppa
Heart Science Centre, Imperial College London, National Heart and Lung Institute, Laboratory of Cellular Electrophysiology, Harefield Hospital, Harefield, Middlesex, UK
Cardiovasc Res 77:695-706. 2008..Clenbuterol (Clen), a beta(2)-adrenoceptor (beta(2)-AR) agonist, has been used as a part of this strategy. In this study, we investigated the direct effects of clenbuterol on unloaded myocardium in HF...
- Continuous intra-amygdalar infusion of GABA in the amygdala kindling model of epilepsy in ratJuan A Barcia
Servicio de Neurologia, Consorcio Hospital General Universitario de Valencia, Valencia 46014, Spain
Epilepsy Res 58:19-26. 2004..To explore the effect of continuous intra-amygdalar infusion of GABA in the amygdala kindling model of epilepsy in rat...
- Assessment and management of patients with implanted intrathecal pumps: ED clinical policy soughtLorene Newberry
J Emerg Nurs 30:8. 2004
- Implantable venous port-related infections in cancer patientsWen Tsung Huang
Division of Hematology Oncology, Department of Internal Medicine, National Cheng Kung University Hospital College of Medicine, 138, Sheng Li Rd, Tainan 704, Taiwan, Republic of China
Support Care Cancer 12:197-201. 2004..To evaluate the characteristics of implantable venous port-related infections in patients with malignancies...
- Continuous intraventricular clonidine infusion in controlled morphine withdrawal--case reportM Lorenz
Department of Neurosurgery, Medizinische Hochschule Hannover, Carl Neuberg Str 1, D 30625, Hannover, Germany
Pain 98:335-8. 2002..Morphine withdrawal with clonidine substitution produced a significant improvement in the analgesic efficacy of morphine and in the quality of life in the absence of undesirable side effects...
- [Intrathecal baclofen therapy]Takaomi Taira
Department of Neurosurgery, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
No Shinkei Geka 36:573-90. 2008
- Mechanical pump dacryoreservoirsJuan Murube
Clinica Murube, Madrid, Spain
Dev Ophthalmol 41:269-82. 2008..A new option is the implantable pump dacryoreservoir...
- Nicotine dose-concentration relationship and pregnancy outcomes in rat: biologic plausibility and implications for future researchJabeen Hussein
Department of Pediatrics, Health Sciences Center, 3330 Hospital Drive NW, Calgary, Alberta, T2N 4N1, Canada
Toxicol Appl Pharmacol 218:1-10. 2007..Our current study has major implications for translational research in developmental toxicology and pharmacotherapy using nicotine replacement treatment as an aid to cessation of cigarette smoking in pregnant mothers...
- Morbidity of adjuvant hepatic arterial infusion pump chemotherapy in the management of colorectal cancer metastatic to the liverRobert C G Martin
University of Louisville Department of Surgery, Division of Surgical Oncology, James Brown Cancer Center, 315 E Broadway, Room 313, Louisville, KY 40202, USA
Am J Surg 188:714-21. 2004..The aim of this study was to examine the survival and toxicity in a single institutional experience with adjuvant HAIP chemotherapy...
- Section on tumors: Young Investigator Award: Local release of carboplatin via an Alzet mini-osmotic pump prolongs survival in a rat brainstem tumor modelQingze Wu
Division of Pediatric Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Clin Neurosurg 51:332-9. 2004
- Pediatric Endocrine/Diabetes Physician ScientistsWilliam Tamborlane; Fiscal Year: 2005..Dr. James Gavin, former President of the ADA and incoming President of Morehouse School of Medicine, has indicated his interest in linking his school to our program in the recruitment of African American trainees. ..
- THERAPY OF HEPATIC METASTASES FROM COLORECTAL CARCINOMANancy Kemeny; Fiscal Year: 2001..Cryosurgery and newer hepatic arterial therapies are therapeutic modalities that can be used in patients in whom liver resection is impossible. ..
- Microinfusion Pump For Animal Functional Brain MappingDANIEL HOLSCHNEIDER; Fiscal Year: 2007..unreadable] [unreadable]..
- AN IMPLANTABLE BOLUS INFUSION PUMP FOR THE NEUROSCIENCESDANIEL HOLSCHNEIDER; Fiscal Year: 2001....
- PET Behavioral Brain Mapping In Freely Moving AnimalsDANIEL HOLSCHNEIDER; Fiscal Year: 2006..Such knowledge may provide the basis of an improved integration of a functional brain anatomy in the context of mental disorders. ..
- AN IMPLANTABLE BOLUS INFUSION PUMP FOR THE NEUROSCIENCESDANIEL HOLSCHNEIDER; Fiscal Year: 2002....
- Characterization of Toxicity with Spinal OpiatesTony L Yaksh; Fiscal Year: 2010..The present studies aim to define the mechanisms of granuloma formation and point to specific methods to prevent granuloma formation, which will increase the utility and reduce the risks of this important pain therapy. ..
- Nasal Delivery of Naltrexone for Treatment of AlcoholismDaniel Wermeling; Fiscal Year: 2006..The long-term goal of this work is to develop and commercialize nasal delivered NTX for the treatment of alcoholism. [unreadable] [unreadable] [unreadable]..
- Mitochondrial respiratory uncoupling and the pathogenes*William Sivitz; Fiscal Year: 2006..This is mediated by one or more UCP subtype. 4. Altered mitochondrial coupling and consequent changes in mitochondrial ROS formation alter endothelial cell generation of nitric oxide. ..
- Pain Mechanisms and the Development of AnalgesicsTony Yaksh; Fiscal Year: 2006..g. COX2 inhibitors, GABApentin, ziconotide) and failures (NK1 antagonist). [unreadable] [unreadable] [unreadable]..
- Neuropathic Pain Modulation by CannabinoidsJianren Mao; Fiscal Year: 2006..A better understanding of cannabinoid actions in neuropathic pain states could open a new avenue to developing novel pharmacological tools for the improved management of often intractable and debilitating neuropathic pain syndromes. ..
- Cocaine Dependence and Cognitive Control of BehaviorClinton Kilts; Fiscal Year: 2006..The long-term goal of these studies is to develop a novel understanding of the processes related to the acquisition, maintenance and social consequences of cocaine addiction. [unreadable] [unreadable]..
- Role of Glutamate in Opiate Tolerance and SensitizationKEITH TRUJILLO; Fiscal Year: 2005..abstract_text> ..
- Antiepileptogenic & Disease Modifying Effects of AEDsAsla Pitkanen; Fiscal Year: 2005..abstract_text> ..
- 'Parent-Child Co-Regulation of Pediatric Diabetes'Linda Gonder Frederick; Fiscal Year: 2005..abstract_text> ..
- Glutamate Signaling and Drug AbuseMOHAMMADHOSSEIN GHASEMZADEH; Fiscal Year: 2007....
- Neurochemical consequences of drugs in adolescent ratsSari Izenwasser; Fiscal Year: 2007....
- Nanoscale approaches to allelic silencing in myocardial disease statesEuan Ashley; Fiscal Year: 2009..This familial condition where the heart grows too thick is the most common cause of sudden death in young people and athletes. ..
- OPIOID-INDUCED PAIN SENSITIVITY: CLINICAL DIAGNOSIS AND MANAGEMENTJianren Mao; Fiscal Year: 2010....
- An fMRI Study of the Impact of Stress on Drug AddictionClinton D Kilts; Fiscal Year: 2010....
- Cocaine behavior: Regulation by k-opioids and serotoninSari Izenwasser; Fiscal Year: 2009..abstract_text> ..
- Micro-and nano-mechanical and chemical guidance of neuronsChristine Schmidt; Fiscal Year: 2008..unreadable] [unreadable]..
- Continuous Treatment with Oxalate Changes Renal Physiology and Morphology (DK0750Susan Ruth Marengo; Fiscal Year: 2008..The objective is to identify those effects which promote these conditions. Future work will determine the mechanism of these effects with the goal of developing an effective preventative therapy. [unreadable] [unreadable] [unreadable]..
- Central Mechanisms of Opiate Reinforcement and DependenceGeorge Koob; Fiscal Year: 2008....
- Fabrication of Novel Biomimetic Polymers Using Combinatorial Peptide ScreeningChristine Schmidt; Fiscal Year: 2008..unreadable] [unreadable]..
- Physiological Studies of Age-Related Hearing LossRICHARD SCHMIEDT; Fiscal Year: 2007..Taken together, the three aims explore the major causes and effects of metabolic presbyacusis and have direct application to future interventions to help restore age-related hearing loss. [unreadable] [unreadable]..
- Imaging the Neural Correlates of Genetic Risk for ADHDClinton Kilts; Fiscal Year: 2005..By uniquely defining the impact of the dat1 VNTR polymorphism on DAT, these findings will generate knowledge of how genes confer vulnerability to ADHD and medication nonresponse. ..
- Periodontal Disease and Rheumatoid ArthritisMichael McCracken; Fiscal Year: 2005..Furthermore, it is hypothesized that among patients with rheumatoid arthritis, an association exists between the rate of progression of inflammatory arthritis and the progression of periodontal disease. ..
- K OPIOIDS AND DOPAMINE--MECHANISMS OF STIMULANT ABUSESari Izenwasser; Fiscal Year: 2001..Hence, the ability to regulate dopaminergic transmission via alterations of the dopamine transporter would be useful in the treatment of such syndromes. ..
- RENAL INJURY AND ADAPTATION TO HEME PROTEINSKarl Nath; Fiscal Year: 2001..Our proposed application thus continues to pursue the functionality of HO-1, as it utilized a new strategy, transgenic mice, and as it defines a new area of involvement namely, renal inflammation. ..
- DEVELOPMENTAL STUDIES OF COCHLEAR MECHANICSDavid Mills; Fiscal Year: 2003..abstract_text> ..
- BEHAVIORAL GENETICS--MODELS/MECHANISMS OF SCHIZOPHRENIAClinton Kilts; Fiscal Year: 2002..abstract_text> ..
- High Field MRI Scanner for Animal StudiesPonnada Narayana; Fiscal Year: 2003..Organizational and financial plans for administering and maintaining the scanner are described. To the best of the PI's knowledge, this will be the only facility of its kind in Houston and the Southwest part of the USA. ..
- BRAIN MONOAMINES AND LUTEINIZING HORMONE SECRETIONWilliam Crowley; Fiscal Year: 2003..abstract_text> ..
- PHYSIOLOGY AND PATHOPHYSIOLOGY OF GROWTH HORMONE VARIANTSusan Kirk; Fiscal Year: 2003..Research Plan: will measure 1) the impact of GH-V on pituitary GH secretion in rats; 2) signal transduction pathways activated by GH-V; 3) the effect of GH-V on glomerular structure in mice. ..
- Oxalate & Crystal Renal Phenotypes: A Microarray StudySusan Ruth Marengo; Fiscal Year: 2003..The long term objective of this work is to establish the mechanism of oxalate induced damage in the kidney. ..
- Behavioral consequences of drug exposure in adolescentsSari Izenwasser; Fiscal Year: 2003....
- CLINICAL RESEARCH IN NEURO-ONCOLOGYROY PATCHELL; Fiscal Year: 2004..abstract_text> ..
- PAIN EVOKED RELEASE OF AMINO ACIDS AND PROSTANOIDSTony Yaksh; Fiscal Year: 2005....
- Cellular Mechanisms of Hyperalgesia and Opioid ToleranceJianren Mao; Fiscal Year: 2005....
- Systems for intra-parenchymal therapy deliveryRaghu Raghavan; Fiscal Year: 2004..abstract_text> ..
- STRUCTURE/ACTIVITY STUDIES OF NPYAmbikaipakan Balasubramaniam; Fiscal Year: 2001..These analogs will have great significance both in fundamental studies as well as in the development of therapeutic drugs for a variety of conditions including feeding disorders and hypertension. ..
- MR Image Analysis in MS: Identification of a SurrogatePonnada Narayana; Fiscal Year: 2002..While the main emphasis is on MS, this system should be readily adaptable to investigate and manage various neurological disorders that require accurate determination of tissue volumes and their temporal change. ..
- 3 T Whole Body Magnetic Resonance ScannerPonnada Narayana; Fiscal Year: 2004..Strong institutional commitment and financial plans for operating the scanner, particularly the long-term maintenance, are described. ..
- MECHANISMS OF VISUAL PLASTICITYARY RAMOA; Fiscal Year: 2005..A better understanding of these mechanisms should provide specific targets to develop novel therapeutic approaches in the treatment of amblyopia. ..
- Glutamate Uptake & the Pathogenesis of Neuropathic PainJianren Mao; Fiscal Year: 2007..abstract_text> ..
- ANGIOTENSIN, LEPTIN, AND THE SYMPATHETIC NERVOUS SYSTEMLisa Cassis; Fiscal Year: 2001....
- NEUROBIOLOGY OF PAINTony Yaksh; Fiscal Year: 2005..The complexity of the problems and the diversity of the training approaches emphasize that the training received by these fellows will provide a broad base of knowledge relevant to wide areas of neurobiology. ..
- Spinal Galanin and its Receptors in Pain ProcessingTony Yaksh; Fiscal Year: 2005..We believe the outcome of these studies will provide direct evidence for the role played by this spinal peptidergic system in pain and point to the development of novel anti-hyperpathic agents. ..
- MAGNETIC RESONANCE OF SPINAL CORD INJURYPonnada Narayana; Fiscal Year: 2006..With recent advances in the treatment of SCI, there is a critical need to noninvasively monitor the efficacy of a given treatment. The proposed MRI and fMRI studies greatly aid realize this goal. ..
- Angiotensin/Sympathetic Interactions and Blood PressureLisa Cassis; Fiscal Year: 2004..Moreover, novel interactions between AngII and leptin in the control of blood pressure may relate to hypertension in the obese population. ..
- Effect of Diabetes on Bone Integration of ImplantsMichael McCracken; Fiscal Year: 2002..This knowledge may lead to bioengineered materials which will modify and improve bone healing response in diabetic patients who receive implants. ..
- MRI of Angiogenesis in Spinal Cord InjuryPonnada Narayana; Fiscal Year: 2009..In addition, it is possible to modulate angiogenesis in conjunction with other treatments, such as cellular grafts to further enhance the recovery from SCI. Thus the proposed studies have a very high degree of clinical relevance. ..
- SERIAL MAGNETIC RESONANCE IN MULTIPLE SCLEROSISPonnada Narayana; Fiscal Year: 2002..A further significance of these studies is that they may enable us to follow objectively and quantitatively the efficacy of drugs in the treatment of MS. ..