infusion pumps

Summary

Summary: Fluid propulsion systems driven mechanically, electrically, or osmotically that are used to inject (or infuse) over time agents into a patient or experimental animal; used routinely in hospitals to maintain a patent intravenous line, to administer antineoplastic agents and other drugs in thromboembolism, heart disease, diabetes mellitus (INSULIN INFUSION SYSTEMS is also available), and other disorders.

Top Publications

  1. ncbi Infusion pump performance with vertical displacement: effect of syringe pump and assembly type
    T A Neff
    Department of Intensive Care and Neonatology, University Children's Hospital, Zurich, Switzerland
    Intensive Care Med 27:287-91. 2001
  2. ncbi Start-up delays of infusion syringe pumps
    T Neff
    Research Group, Department of Intensive Care and Neonatology, University Children's Hospital, Zurich, Switzerland
    Paediatr Anaesth 11:561-5. 2001
  3. ncbi Pediatric models for adult target-controlled infusion pumps
    Brian J Anderson
    Department of Anaesthesiology, University of Auckland, Auckland, New Zealand
    Paediatr Anaesth 20:223-32. 2010
  4. ncbi Heuristic evaluation of infusion pumps: implications for patient safety in Intensive Care Units
    Mark J Graham
    Department of Biomedical Informatics, College of Physicians and Surgeons, Columbia University, USA
    Int J Med Inform 73:771-9. 2004
  5. ncbi Chronic, controlled GDNF infusion promotes structural and functional recovery in advanced parkinsonian monkeys
    Richard Grondin
    Department of Anatomy and Neurobiology, University of Kentucky Medical Center, Rm 305 Davis Mills Building, 800 Rose Street, Lexington, KY, USA
    Brain 125:2191-201. 2002
  6. ncbi Electromagnetic interference with infusion pumps from GSM mobile phones
    Giovanni Calcagnini
    Department of Technology and Health, Italian Institute of Health, Rome, Italy
    Health Phys 90:357-60. 2006
  7. ncbi Continuous subcutaneous terbutaline administration prolongs pregnancy after recurrent preterm labor
    John C Morrison
    Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, USA
    Am J Obstet Gynecol 188:1460-5; discussion 1465-7. 2003
  8. ncbi The pain control infusion pump for postoperative pain control in shoulder surgery
    F H Savoie
    Mississippi Sports Medicine and Orthopaedic Center, Jackson, MS 39202, USA
    Arthroscopy 16:339-42. 2000
  9. pmc Predictive performance of 'Diprifusor' TCI system in patients during upper abdominal surgery under propofol/fentanyl anesthesia
    Yu Hong Li
    Department of Anesthesiology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
    J Zhejiang Univ Sci B 6:43-8. 2005
  10. ncbi Modeling the effect of propofol and remifentanil combinations for sedation-analgesia in endoscopic procedures using an Adaptive Neuro Fuzzy Inference System (ANFIS)
    P L Gambus
    Anesthesiology Department, Hospital Clinic de Barcelona, Barcelona, Spain
    Anesth Analg 112:331-9. 2011

Detail Information

Publications233 found, 100 shown here

  1. ncbi Infusion pump performance with vertical displacement: effect of syringe pump and assembly type
    T A Neff
    Department of Intensive Care and Neonatology, University Children's Hospital, Zurich, Switzerland
    Intensive Care Med 27:287-91. 2001
    ..The variability across syringe pumps indicates that syringe pump design remains an area of potential further improvement for reducing the risk of adverse patient events...
  2. ncbi Start-up delays of infusion syringe pumps
    T Neff
    Research Group, Department of Intensive Care and Neonatology, University Children's Hospital, Zurich, Switzerland
    Paediatr Anaesth 11:561-5. 2001
    ..CONCLUSIONS: Syringe pump design affects start-up delay times because of free play of the syringe. These delays can be eliminated by a start-up bolus of 2 ml prior to connecting the infusion line to the patient...
  3. ncbi Pediatric models for adult target-controlled infusion pumps
    Brian J Anderson
    Department of Anaesthesiology, University of Auckland, Auckland, New Zealand
    Paediatr Anaesth 20:223-32. 2010
    ..Both PK and PD are necessary for safe use of TCI pumps...
  4. ncbi Heuristic evaluation of infusion pumps: implications for patient safety in Intensive Care Units
    Mark J Graham
    Department of Biomedical Informatics, College of Physicians and Surgeons, Columbia University, USA
    Int J Med Inform 73:771-9. 2004
    ..of this research was to use a heuristic evaluation methodology to uncover design and interface deficiencies of infusion pumps that are currently in use in Intensive Care Units (ICUs)...
  5. ncbi Chronic, controlled GDNF infusion promotes structural and functional recovery in advanced parkinsonian monkeys
    Richard Grondin
    Department of Anatomy and Neurobiology, University of Kentucky Medical Center, Rm 305 Davis Mills Building, 800 Rose Street, Lexington, KY, USA
    Brain 125:2191-201. 2002
    ..Additional studies are required to determine the potential differences between chronic, intraventricular and intraputamenal (or intranigral) delivery of GDNF to maximize the efficacy of infusion treatments...
  6. ncbi Electromagnetic interference with infusion pumps from GSM mobile phones
    Giovanni Calcagnini
    Department of Technology and Health, Italian Institute of Health, Rome, Italy
    Health Phys 90:357-60. 2006
    ..5 mW at 1,800 MHz. In state-of-the-art pumps, the presence of moderate-good base station coverage would significantly reduce the risk of electromagnetic interference...
  7. ncbi Continuous subcutaneous terbutaline administration prolongs pregnancy after recurrent preterm labor
    John C Morrison
    Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, USA
    Am J Obstet Gynecol 188:1460-5; discussion 1465-7. 2003
    ..This study was undertaken to study the effectiveness of continuous subcutaneous terbutaline (SQT) in the home after recurrent preterm labor (RPTL)...
  8. ncbi The pain control infusion pump for postoperative pain control in shoulder surgery
    F H Savoie
    Mississippi Sports Medicine and Orthopaedic Center, Jackson, MS 39202, USA
    Arthroscopy 16:339-42. 2000
    ..This study was initiated to evaluate the effect of a pain control infusion catheter in managing postoperative pain...
  9. pmc Predictive performance of 'Diprifusor' TCI system in patients during upper abdominal surgery under propofol/fentanyl anesthesia
    Yu Hong Li
    Department of Anesthesiology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
    J Zhejiang Univ Sci B 6:43-8. 2005
    ..To evaluate the predictive performance of 'Diprifusor' TCI (target-controlled infusion) system for its better application in clinical anesthesia...
  10. ncbi Modeling the effect of propofol and remifentanil combinations for sedation-analgesia in endoscopic procedures using an Adaptive Neuro Fuzzy Inference System (ANFIS)
    P L Gambus
    Anesthesiology Department, Hospital Clinic de Barcelona, Barcelona, Spain
    Anesth Analg 112:331-9. 2011
    ....
  11. ncbi A controlled trial of smart infusion pumps to improve medication safety in critically ill patients
    Jeffrey M Rothschild
    Division of General Medicine and Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Crit Care Med 33:533-40. 2005
    ..Errors associated with the administration of medications through intravenous infusion pumps to critically ill patients can result in adverse drug events...
  12. ncbi Granulocyte-macrophage colony-stimulating factor stimulates arteriogenesis in a pig model of peripheral artery disease using clinically applicable infusion pumps
    Sebastian Grundmann
    Department of Cardiology and Angiology, University Hospital Freiburg, Freiburg, Germany
    J Vasc Surg 43:1263-9. 2006
    ..application in patients with PAD, we hypothesized that intra-arterial cytokine application using implantable infusion pumps might well stimulate arteriogenesis in a large-species model of peripheral vascular disease...
  13. ncbi The effectiveness of an anesthetic continuous-infusion device on postoperative pain control
    F Alan Barber
    Plano Orthopedic and Sports Medicine Center, Plano, The Advanced Surgical Institutes, Medical City Dallas Hospital, Dallas, Texas, USA
    Arthroscopy 18:76-81. 2002
    ..To evaluate the effectiveness of an anesthetic continuous-infusion device on postoperative pain after outpatient shoulder surgery...
  14. ncbi Preventing medication errors with smart infusion technology
    Karen Wilson
    Vanderbilt University Medical Center VUMC, 1161 21st Avenue, Room B101, Nashville, TN 37232 7610, USA
    Am J Health Syst Pharm 61:177-83. 2004
    ..Processes that pharmacists can use to identify high-risk areas and drugs that require special focus in error-prevention efforts are discussed, with emphasis on the need for i.v. medication error prevention...
  15. pmc Insights from the sharp end of intravenous medication errors: implications for infusion pump technology
    M Husch
    Patient Safety Team, Northwestern Memorial Hospital, Feinberg School of Medicine, Northwestern University, 676 North St Claire, Chicago, IL 60611, USA
    Qual Saf Health Care 14:80-6. 2005
    ..Over the past 20 years there have been several hundred FDA reported incidents involving IV pumps, many of which have led to patient deaths...
  16. pmc Changes in insulin sensitivity during leptin replacement therapy in leptin-deficient patients
    Gilberto Paz-Filho
    Dept of Psychiatry and Behavioral Sciences, Univ of Miami Miller School of Medicine, Miami, FL 33136, USA
    Am J Physiol Endocrinol Metab 295:E1401-8. 2008
    ..Our results suggest that hyperleptinemia may contribute to mediate the increased insulin resistance of obesity...
  17. ncbi Use of failure mode and effects analysis in improving the safety of i.v. drug administration
    Wayne Adachi
    Good Samaritan Hospital, San Jose, CA, USA
    Am J Health Syst Pharm 62:917-20. 2005
    ..Failure mode and effects analysis (FMEA) was used to identify dosing and administration errors associated with i.v. medications and evaluate the effectiveness of subsequent system improvements...
  18. ncbi Perioperative continuous peripheral nerve blocks with disposable infusion pumps in children: a prospective descriptive study
    Christophe Dadure
    Department of Anesthesia and Critical Care Medicine, Lapeyronie University Hospital, Montpellier, France
    Anesth Analg 97:687-90. 2003
    ..Sensory and motor block were noted at H1 and decreased from the sixth hour. No adverse events were noted. We concluded that the use of elastomeric disposable pumps for CPNB in children was an effective technique...
  19. ncbi Standard drug concentrations and smart-pump technology reduce continuous-medication-infusion errors in pediatric patients
    Gitte Y Larsen
    Primary Children s Medical Center, PICU, PO Box 581289, Salt Lake City, UT 84158 1289, USA
    Pediatrics 116:e21-5. 2005
    ..To determine if combining standard drug concentrations with "smart-pump" technology reduces reported medication-infusion errors...
  20. ncbi Disposable infusion pumps
    Elena A Skryabina
    Pump Evaluation Laboratory, Bath Institute of Medical Engineering, University of Bath, Wolfson Centre, Royal United Hospital, Combe Park, Bath, United Kingdom
    Am J Health Syst Pharm 63:1260-8. 2006
    The properties, performance, and applications of nonelectric disposable infusion pumps are reviewed.
  21. ncbi Smart infusion technology: a minimum safety standard for intensive care?
    Linda J Murdoch
    Department of Paediatric Intensive Care, St George s Hospital, London
    Br J Nurs 17:630-6. 2008
    ..It is the authors' firm belief that smart infusion technology sets a new minimum safety standard for intensive care...
  22. ncbi Intra-articular pain pump catheter breakage after arthroscopic shoulder surgery: a case series
    Tara T Holmes
    Department of Sports Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 8300, USA
    J Shoulder Elbow Surg 16:e6-9. 2007
  23. ncbi A comparison between single and double-pump syringe changes of intravenous inotropic medications in children
    Margaret L Powell
    Pediatric Intensive Care Unit, Montreal Children s Hospital, Montreal, QC
    Dynamics 15:10-4. 2004
    ..However, the SP practice can also be highly suitable when considering the overall benefits and risks of both practices of syringe changes. Implications for nursing are discussed...
  24. ncbi [Potential advantages a new syringe pump system]
    L Vachon
    Departement d Anesthesie Reanimation, CHU d Angers, 49033 Angers, France
    Ann Fr Anesth Reanim 21:354-8. 2002
    ..To evaluate what could be the benefit in terms of alarm suppression, of a new syringe pumps system, which allows automatic relay without alarms...
  25. ncbi Downward movement of syringe pumps reduces syringe output
    H Kern
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Charite, Humboldt University of Berlin, Germany
    Br J Anaesth 86:828-31. 2001
    ..05). We conclude that the height of the syringe pumps should not be changed during transportation. If vertical movement of the syringe pump is necessary, the drugs should be diluted so that the flow rate is at least 5 ml h(-1)...
  26. ncbi Practical considerations in the administration of intravenous vasoactive drugs in the critical care setting: the double pumping or piggyback technique-part one
    Joanna C Trim
    Clinical Skills Centre, J Block, Selly Oak Hospital, Birmingham B29 6JD, UK
    Intensive Crit Care Nurs 20:153-60. 2004
    ..protocol for administering continuous intravenous vasoactive medication and technological developments in infusion pumps, a review of current literature was undertaken...
  27. ncbi Enteral levodopa/carbidopa gel infusion for the treatment of motor fluctuations and dyskinesias in advanced Parkinson's disease
    Dag Nyholm
    Department of Neuroscience, Neurology, Uppsala University Hospital, SE 75185, Uppsala, Sweden
    Expert Rev Neurother 6:1403-11. 2006
    ..The infusion provides smooth plasma levodopa levels, more continuous dopaminergic stimulation and effective treatment of motor complications...
  28. ncbi The efficacy of continuous bupivacaine infiltration following arthroscopic rotator cuff repair
    Sarah S Banerjee
    Texas Tech University Health Sciences Center School of Medicine, El Paso, Texas, USA
    Arthroscopy 24:397-402. 2008
    ..This prospective, randomized, double-blind study with a placebo group and 2 experimental groups evaluated the efficacy of continuous low-dose bupivacaine infiltration by infusion pump after arthroscopic rotator cuff repair...
  29. ncbi Cross-tolerance between spinal neostigmine and morphine in the rat
    S A Dunbar
    Department of Anesthesiology, Tufts University School of Medicine, Baystate Medical Center, Springfield, MA 01199, USA
    Br J Anaesth 91:427-9. 2003
    ..t.). This study examines whether spinal neostigmine tolerance and cross-tolerance to spinal morphine occurs...
  30. pmc Reinforcement enhancing effect of nicotine and its attenuation by nicotinic antagonists in rats
    Xiu Liu
    Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Psychopharmacology (Berl) 194:463-73. 2007
    ..Recent studies have demonstrated that nicotine can enhance operant responding for other nonpharmacological reinforcing stimuli. However, the nature of the reinforcement-enhancing effect of nicotine remains largely unknown...
  31. ncbi Postoperative analgesia after cesarean section by continued administration of levobupivacaine with the On-Q Painbuster system over the fascia vs ketorolac + morphine i.v
    E Magnani
    Department of Gynecology, University of Rome La Sapienza, Rome, Italy
    Clin Exp Obstet Gynecol 33:223-5. 2006
    ..This study aimed to detect if continuous local infusion of levobupivacaine with the On-Q Painbuster system provided postoperative analgesia of similar quality to morphine + ketorolac i.v. in patients undergoing cesarean section...
  32. ncbi Toxicological study of a new maintenance fluid, Veen 3G, in rats
    J Kamei
    Department of Pathophysiology and Therapeutics Faculty of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Tokyo, Japan
    Methods Find Exp Clin Pharmacol 24:493-6. 2002
    ..Since this rate is about 27-80 times higher than that used clinically in maintenance treatment, Veen 3G is suggested to be safe, with the exception of polyuria, in clinical situations at the standard infusion rate (5-15 ml/kg/h)...
  33. ncbi Local anaesthetic infusion for postoperative pain
    M Kulkarni
    Hand Surgery Department, St Andrew s Centre for Plastic Surgery, Broomfield Hospital, Chelmsford, Essex, UK
    J Hand Surg Br 28:300-6. 2003
    ..Two patients developed infection at the infusion cannula insertion site, which occurred only after 1 week and was successfully treated by removal of the cannula and oral antibiotics...
  34. ncbi Effect of monthly administration of GHRH (fragment 1-29) with osmotic pump on the rat anterior pituitary
    Ewelina Motylewska
    Department of Immunoendocrinology, Medical University of Łódź, Poland
    Endokrynol Pol 56:927-32. 2005
    ..Summing up, monthly GHRH administration did not induce somatotrope adenomas but it caused serum GH level elevation, what seems to depend partially on the increase of somatotrope number...
  35. ncbi [Cost-effectiveness analysis of patient-controlled analgesia compared to continuous elastomeric pump infusion of tramadol and metamizole]
    D Hernández García
    Servicio de Anestesiologia y Reanimacion, Hospital Universitario de Valme, Sevilla
    Rev Esp Anestesiol Reanim 54:213-20. 2007
    ..Little information is available on the cost-effectiveness of postoperative patient-controlled analgesia (PCA). The present study compared PCA to continuous infusion by elastomeric pump...
  36. ncbi A comparative study of patient-controlled epidural diamorphine, subcutaneous diamorphine and an epidural diamorphine/bupivacaine combination for postoperative pain
    C Gopinathan
    Pain Relief Research Unit, King's College Hospital, Denmark Hill, London, UK
    Eur J Anaesthesiol 17:189-96. 2000
    ..05). This study indicates that the use of PCA epidural diamorphine, either alone or in combination with bupivacaine, reduces the dose requirement for analgesia but offers little clinical advantage over subcutaneous PCA diamorphine...
  37. ncbi Influence of sex, estrous cycle, and drug-onset age on cocaine self-administration in rats (Rattus norvegicus)
    Kathleen M Kantak
    Laboratory of Behavioral Neuroscience, Boston University, Boston, MA 02215, USA
    Exp Clin Psychopharmacol 15:37-47. 2007
    ..0-mg/kg unit dose and low FR) may be useful for evaluating potential sex or age differences in the consequences of cocaine self-administration more reliably, as cocaine intake would not be an uncontrolled factor...
  38. ncbi Time course and dose response of relaxin-mediated renal vasodilation, hyperfiltration, and changes in plasma osmolality in conscious rats
    Lee A Danielson
    Magee Womens Research Institute, 204 Craft Ave, Pittsburgh, PA 15213, USA
    J Appl Physiol 95:1509-14. 2003
    ..These findings may be important to consider when evaluating relaxin in the treatment of renal disease...
  39. ncbi A portable, disposable device for patient-controlled epidural analgesia following Caesarean section: evaluation by patients and nurses
    S Banks
    Department of Anaesthesia, King Edward Memorial Hospitalfor Women, Subiaco, Western Australia, Australia
    Aust N Z J Obstet Gynaecol 41:372-5. 2001
    ..The patients expressed a high level of satisfaction with the device and all would use it again if offered the chance. We conclude that the Go Medical epidural infuser is a safe and effective device as used in the postnatal ward setting...
  40. pmc The effects of varying local anesthetic concentration and volume on continuous popliteal sciatic nerve blocks: a dual-center, randomized, controlled study
    Brian M Ilfeld
    Department of Anesthesiology, University of California San Diego, San Diego, CA, USA
    Anesth Analg 107:701-7. 2008
    ..We therefore tested the null hypothesis that providing different concentrations and rates of ropivacaine, but at equal total doses, produces comparable effects when used in a continuous sciatic nerve block in the popliteal fossa...
  41. ncbi Continuous intra-articular infusion of bupivacaine for postoperative pain following total knee arthroplasty
    Jeffrey Nechleba
    Department of Orthopedics, Hamot Medical Center, Erie, PA 16550, USA
    J Knee Surg 18:197-202. 2005
    ..Drug loss from drainage may exceed 25% and may compromise analgesic effectiveness...
  42. ncbi Use of the infusion pain pump following transverse rectus abdominis muscle flap breast reconstruction
    Albert Losken
    Emory Division of Plastic and Reconstructive Surgery, Paces Plastic Surgery, Atlanta, GA 30308, USA
    Ann Plast Surg 54:479-82. 2005
    ..There were no flap, donor-site, or implant complications related to the presence of the catheter. Cost-effectiveness and patient satisfaction data would be interesting...
  43. ncbi Bupivacaine wound instillation via an electronic patient-controlled analgesia device and a double-catheter system does not decrease postoperative pain or opioid requirements after major abdominal surgery
    B Fredman
    Department of Anesthesiology, Meir Hospital, Kfar Saba, Israel
    Anesth Analg 92:189-93. 2001
    ..25% bupivacaine wound instillation via an electronic patient-controlled analgesia device and a double-catheter system does not decrease postoperative pain or opioid requirements...
  44. ncbi Analgesic efficacy of continuous delivery of bupivacaine by an elastomeric balloon infusor after abdominal hysterectomy: a prospective randomised controlled trial
    W M Leong
    Department of Anaesthesia, Changi General Hospital, Singapore, Singapore
    Aust N Z J Obstet Gynaecol 42:515-8. 2002
    ..To investigate the analgesic efficacy and morphine-sparing effect of continuous bupivacaine wound infiltration after abdominal hysterectomy...
  45. ncbi A comparison of intrathecal morphine/fentanyl and patient-controlled analgesia with patient-controlled analgesia alone for analgesia after liver resection
    Jean Denis Roy
    Department ofAnesthesiology, Centre Hospitalier de l Universite de Montreal, Hôpital St Luc, Montreal, Quebec, Canada
    Anesth Analg 103:990-4. 2006
    ..Intrathecal morphine (0.5 mg) and fentanyl (15 microg) given before liver surgery significantly decreased postoperative morphine consumption compared to placebo without any increase in side effects...
  46. ncbi A comparison of the effects of patient-controlled analgesia with intravenous opioids versus Epidural analgesia on recovery after surgery for idiopathic scoliosis
    D H Van Boerum
    Department of Orthopedics, University of Utah, Salt Lake City, Utah, USA
    Spine (Phila Pa 1976) 25:2355-7. 2000
    ..In the current study, patients tolerated a full diet and were discharged from the hospital an average of 0.5 days earlier than PCA-treated patients...
  47. ncbi Pancreatic resection pain management: is combining PCA therapy and a continuous local infusion of 0.5% ropivacaine beneficial?
    Traci K Thompson
    Pancreas 37:103-4. 2008
  48. ncbi [The effects of patient-controlled epidural analgesia with background infusion after abdominal surgery]
    Masanori Yamauchi
    Department of Anesthesia, Oji General Hospital, Tomakomai, 053 8506
    Masui 53:29-33. 2004
    ..We evaluated the effects of PCEA with background infusion after major abdominal surgery...
  49. ncbi [Continuous femoral nerve block to control postoperative pain in outpatient orthopedic surgery]
    S López Alvarez
    Servicio Anestesiología, Reanimacion y Terapeutica del Dolor, Unidad de Cirugía sin Ingreso del Hospital Abente y Lago, Complexo Hospitalario Universitario Juan Canalejo, A Coruna
    Rev Esp Anestesiol Reanim 54:227-30. 2007
    ..We therefore studied the efficacy, feasibility, and safety of the continuous femoral nerve block as an analgesic technique for outpatient anterior cruciate ligament reconstruction...
  50. pmc Ambulatory continuous posterior lumbar plexus nerve blocks after hip arthroplasty: a dual-center, randomized, triple-masked, placebo-controlled trial
    Brian M Ilfeld
    Department of Anesthesiology, University of California San Diego Center for Pain Medicine, 9300 Campus Point Drive, MC 7651, La Jolla, California 92037 7651, USA
    Anesthesiology 109:491-501. 2008
    ....
  51. ncbi A "new" automated bolus technique for continuous popliteal block: a prospective, randomized comparison with a continuous infusion technique
    Manuel Taboada
    Department of Anesthesiology, Hospital Clinico Universitario de Santiago, Travesía da Choupana s n 15706 Santiago de Compostela, Spain
    Anesth Analg 107:1433-7. 2008
    ....
  52. ncbi High-dose 5-fluorouracil / folinic acid in combination with three-weekly mitomycin C in the treatment of advanced gastric cancer. A phase II study
    R D Hofheinz
    Onkologisches Zentrum, III Medizinische Klinik Universitätsklinikum Mannheim, Hamburg
    Onkologie 25:255-60. 2002
    ..In order to improve this MMC-dependent schedule we initiated a phase II study with high-dose 5-FU/FA and 3-weekly bolus MMC...
  53. ncbi Effects of continuous lumbar intrathecal infusion of leptin in rats on weight regulation
    Tony L Yaksh
    Department of Anesthesiology, Univeristy of California, San Diego 92093 0818, USA
    Neuroscience 110:703-10. 2002
    ..The observed correlation of cisternal leptin levels with the behavioral effects is also consistent with a reliable distribution of the infused leptin to target supraspinal sites...
  54. ncbi Relationship between bispectral index, electroencephalographic state entropy and effect-site EC50 for propofol at different clinical endpoints
    M Iannuzzi
    Department of Anaesthesiological, Surgical and Emergency Sciences, Second Service of Anaesthesia, Second University of Naples, Naples, Italy
    Br J Anaesth 94:613-6. 2005
    ....
  55. ncbi Loss of antinociceptive efficacy in rat pups infused with morphine from osmotic minipumps
    Dawn C Stoller
    Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298 0613, USA
    Pharmacology 66:11-8. 2002
    ..However, this effect cannot be attributed to changes in mu-opioid receptor number or affinity...
  56. ncbi Relationship between Bispectral Index, electroencephalographic state entropy and effect-site EC50 for propofol at different clinical endpoints
    M Iannuzzi
    Department of Anaesthesiological, Surgical and Emergency Sciences, Second Service of Anaesthesia and Department of Experimental Medicine, Second University of Naples, Naples, Italy
    Br J Anaesth 94:492-5. 2005
    ....
  57. ncbi Comparison of intermittent and continuous palliative chemotherapy for advanced colorectal cancer: a multicentre randomised trial
    T S Maughan
    Department of Oncology, Velindre Hospital, Cardiff, UK
    Lancet 361:457-64. 2003
    ..Policies of UK clinicians regarding the duration of chemotherapy for patients with advanced colorectal cancer are not consistent. We aimed to compare effectiveness of continuous and intermittent chemotherapy in such patients...
  58. ncbi Tolerance and dependence following chronic intracerebroventricular infusions of Tyr-D-Arg2-Phe-Sar4 (TAPS)
    Stefan Vonhof
    Department of Cardiology and Pneumology, Georg August University, Robert Koch Str 40, 37075, Gottingen, Germany
    Eur J Pharmacol 459:41-8. 2003
    ..In contrast to DAMGO, TAPS retains its antinociceptive effect following bolus administration in rats rendered tolerant to mu-opioid receptor agonists...
  59. ncbi Intravenous lacosamide as replacement for oral lacosamide in patients with partial-onset seizures
    Victor Biton
    Arkansas Epilepsy Program, Little Rock, Arkansas 77025, USA
    Epilepsia 49:418-24. 2008
    ..This multicenter, double-blind, double-dummy, randomized, inpatient trial evaluated the safety, tolerability, and pharmacokinetics of intravenous lacosamide as replacement for oral lacosamide in patients with partial-onset seizures...
  60. ncbi Capillary endothelial thrombomodulin expression and fibrin deposition in rats with continuous and bolus lipopolysaccharide administration
    Yasuji Terada
    Department of Thoracic Surgery, Nagahama City Hospital, Nagahama, Japan
    Lab Invest 83:1165-73. 2003
    ..Endothelial injury by LPS administration is dependent on the dose of LPS and the duration of treatment. The amount of fibrin deposition differs among organs and with the duration of contact between the endothelium and the endotoxin...
  61. ncbi ANG II increases TIMP-1 expression in rat aortic smooth muscle cells in vivo
    Giovanna Castoldi
    Unitá Didattico Assistenziale Nefrocardiovascolare, Dipartimento di Medicina Clinica, Prevenzione e Biotecnologie Sanitarie, Università degli Studi di Milano Bicocca 20052, Monza, Italy
    Am J Physiol Heart Circ Physiol 284:H635-43. 2003
    ..In vivo, both short- and long-term chronic ANG II treatments increase TIMP-1 expression in the rat aorta. TIMP-1 induction by ANG II in aortic smooth muscle cells occurs in the absence of histological changes at the vascular wall...
  62. ncbi Less is more: antipsychotic drug effects are greater with transient rather than continuous delivery
    Anne Noël Samaha
    Schizophrenia Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Biol Psychiatry 64:145-52. 2008
    ..Based on prior data, we predicted that variations in the within-day kinetics of antipsychotic drug delivery would produce different outcomes, even if we held achieved dose, route, and total duration of treatment constant...
  63. ncbi Patient-controlled analgesia
    Jeffrey A Grass
    Department of Anesthesiology, Western Pennsylvania Hospital and Allegheny General Hospital, Pittsburgh, Pennsylvania 15224, USA
    Anesth Analg 101:S44-61. 2005
    ..In addition, potential adverse effects and recommendations for their monitoring and treatment are reviewed...
  64. ncbi Effects of recurrent withdrawal on spinal GABA release during chronic morphine infusion in the rat
    Stuart A Dunbar
    Department of Anesthesiology, Baystate Medical Center, Tufts University, 3400 Main Street, Springfield, MA 01199, USA
    Eur J Pharmacol 535:152-6. 2006
    ..These observed changes in GABA release offer direct evidence that GABA may contribute to the altered nociceptive response mediated by opioids...
  65. ncbi Prodrug of proline analogue reduces hypoxic pulmonary hypertension in rats
    Paul M Simon
    VectraMed, Inc, 116 Village Boulevard, Suite 200, Princeton, NJ 08540, USA
    Pulm Pharmacol Ther 19:242-50. 2006
    ..c. infusion, and has favorable pharmacokinetic properties. Potent inhibitors of fibrosis appear to be promising agents in treating pulmonary hypertension and possibly other fibrosing diseases...
  66. ncbi Antipsychotic dosing in preclinical models is often unrepresentative of the clinical condition: a suggested solution based on in vivo occupancy
    Shitij Kapur
    Centre for Addiction and Mental Health, Clarke Site 250 College Street Toronto, Ontario Canada M5R 1T8
    J Pharmacol Exp Ther 305:625-31. 2003
    ..The study provides a rationale as well as clinically comparable dosing regimens for animal studies and raises questions about the inferences drawn from previous studies that have used doses unrepresentative of the clinical situation...
  67. pmc Local anaesthetic infusion with elastomeric pump after arthroscopic subacromial decompression
    Kevin Little
    West of Scotland Deanery Orthopaedic Rotation, Glasgow, UK
    Ann R Coll Surg Engl 89:410-3. 2007
    ..We present our experience with a portable elastomeric infusion device in patients undergoing arthroscopic subacromial decompression, and make a case for its potential to allow same-day discharge...
  68. ncbi Randomized trial of a pain control infusion pump following inguinal hernia repair
    Adam Stewart
    Queen Elizabeth II Jubilee Hospital, Coopers Plains Queensland, Australia
    ANZ J Surg 74:873-6. 2004
    ..The purpose of the present paper is to evaluate this form of analgesia following open anterior inguinal hernia repair by way of a pain control infusion pump (PCIP)...
  69. ncbi Efficacy of the pain pump catheter in immediate autologous breast reconstruction
    Michael Baroody
    Division of Plastic Surgery, Pennsylvania State University, Hershey Medical Center, USA
    Plast Reconstr Surg 114:895-8; discussion 899-900. 2004
    ....
  70. ncbi The efficacy of continuous local anesthetic infiltration in breast surgery: reduction mammaplasty and reconstruction
    Leonard Lu
    Department of Plastic Surgery, Northwestern Memorial Hospital, Chicago, Ill, USA
    Plast Reconstr Surg 115:1927-34; discussion 1935-6. 2005
    ..Regional and local anesthetic techniques are increasing in popularity because they decrease the use of intravenous analgesic medications and offer comparable pain relief without the systemic side effects...
  71. ncbi Evaluation of continuous infusion of 0.5% bupivacaine by elastomeric pump for postoperative pain management after open inguinal hernia repair
    Karl A LeBlanc
    Surgical Specialty Group Inc, Baton Rouge, LA 70808, USA
    J Am Coll Surg 200:198-202. 2005
    ..Postoperative pain management and narcotic usage after inguinal hernia repair is an important concern for anesthesiologists and surgeons. Regional anesthesia incisional infiltration techniques may reduce the need for systemic medications...
  72. ncbi Epidural analgesia and risk of anastomotic leakage
    K Holte
    Department of Surgical Gastroenterology, Hvidovre University Hospital, Hvidovre, Denmark
    Reg Anesth Pain Med 26:111-7. 2001
    ..However, relatively few patients have been included in randomized trials, indicating a need for more studies to secure valid conclusions...
  73. ncbi Morphine overdose from error propagation on an acute pain service
    Summer Syed
    Department of Anesthesia, 237 Barton Street East, Hamilton, Ontario L8L 2X2, Canada
    Can J Anaesth 53:586-90. 2006
    ..To highlight a case in which multiple errors occurred during programming and administration of analgesia via a patient-controlled analgesia (PCA) pump, and to formulate recommendations on how to avoid such errors in the future...
  74. ncbi The use of intrathecal morphine for analgesia after posterolateral lumbar fusion: a prospective, double-blind, randomized study
    J C France
    University of Colorado and affiliated hospitals, Denver, USA
    Spine (Phila Pa 1976) 22:2272-7. 1997
    ..There were no significant complications related to the analgesia. CONCLUSIONS: Intrathecal morphine can be safe and efficacious as an early postoperative analgesic after lumbar fusion when respiratory monitoring is used...
  75. ncbi Taking aim at infusion confusion
    Gabrielle Burdeu
    Alfred Hospital, Melbourne, Victoria, Australia
    J Nurs Care Qual 21:151-9. 2006
    ..Key safety design concepts such as standardization, simplification, and forcing functions were also used...
  76. ncbi Intraosseous infusion into the skull: potential application for the management of hydrocephalus
    Jeffrey A Pugh
    Department of Surgery, University of Alberta, Edmonton, Alberta, Canada
    J Neurosurg 106:120-5. 2007
    ..The focus of this work has been to recreate more normal CSF absorption into the dural venous sinuses without having to directly access the superior sagittal sinus (SSS)...
  77. ncbi Patient safety challenges in treprostinil therapy
    Agnes Roncesvalles
    University Medical Center, Tucson, AZ, USA
    Medsurg Nurs 17:101-6. 2008
    ..Treprostinil (Remodulin) is a new therapy for pulmonary hypertension. A multidisciplinary plan for safely managing the drug is described, and includes a flow chart to guide practice through high-risk issues...
  78. ncbi Delivery of intravenous treprostinil at low infusion rates using a miniaturized infusion pump in patients with pulmonary arterial hypertension
    V F Tapson
    Duke University Medical Center, Durham, NC 27710, USA
    J Vasc Access 7:112-7. 2006
    ..Treprostinil's anti-platelet aggregation characteristics and stability at room temperature may allow for low infusion rates (0.1-0.2 mL/hr) using a miniaturized infusion pump...
  79. ncbi Programming errors contribute to death from patient-controlled analgesia: case report and estimate of probability
    Kim J Vicente
    Department of Aeronautics and Astronautics, Massachusetts Institute of Technology, Massachusetts, USA
    Can J Anaesth 50:328-32. 2003
    ..To identify the factors that threaten patient safety when using patient-controlled analgesia (PCA) and to obtain an evidence-based estimate of the probability of death from user programming errors associated with PCA...
  80. ncbi Smart i.v. pumps
    Sally Beattie Dulak
    CV Health Promotion, Columbia, MO, USA
    RN 68:38-43; quiz 44. 2005
  81. ncbi Efficacy of a local anesthetic pain pump in abdominoplasty
    David A Bray
    Methodist Hospital Plastic Surgery Residency Program and the Department of Plastic Surgery, Christus St Joseph Hospital, Houston, Texas 77002, USA
    Plast Reconstr Surg 119:1054-9. 2007
    Recently, pain infusion pumps for postoperative pain control have gained popularity in many surgical specialties...
  82. ncbi Chronic local therapy for brainstem tumors
    Michael Guarnieri
    Neurosurgery 54:1025-6; author reply 1026-7. 2004
  83. ncbi Pressurized bag pump and syringe pump arterial flushing systems: an unrecognized hazard in neonates?
    A Cornelius
    Department of Anesthesia, University Children s Hospital Zurich, Steinwiesstrasse 75 8032 Zurich, Switzerland
    Intensive Care Med 28:1638-43. 2002
    ..We studied flush flow velocities during intermittent arterial line purging using a flow regulating device with an infusion bag pump and a syringe pump system...
  84. ncbi Intermittent vs continuous administration of epidural ropivacaine with fentanyl for analgesia during labour
    P D W Fettes
    University Department of Anaesthesia, Ninewells Hospital and Medical School Dundee DD1 9SY, UK
    Br J Anaesth 97:359-64. 2006
    ....
  85. ncbi Postoperative continuous paravertebral anesthetic infusion for pain control in lumbar spinal fusion surgery
    James B Elder
    Department of Neurosurgery, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
    Spine (Phila Pa 1976) 33:210-8. 2008
    ..case-control study was conducted to analyze postoperative outcomes in patients who received local anesthetic infusion pumps after lumbar spinal fusion procedures...
  86. ncbi Cyproheptadine for intrathecal baclofen withdrawal
    Jay M Meythaler
    Department of Physical Medicine and Rehabilitation, University of Alabama School of Medicine and the University of Alabama Spain Rehabilitation Center, Birmingham 35249 7330, USA
    Arch Phys Med Rehabil 84:638-42. 2003
    ..To evaluate the efficacy of cyproheptadine in the management of acute intrathecal baclofen (ITB) withdrawal...
  87. ncbi Safer cordocentesis by new 25-gauge needles
    Yuichi Kawakami
    Department of Obstetrics and Gynecology, National Defense Medical College, Tokorozawa, Japan
    Fetal Diagn Ther 24:211-7. 2008
    ..The objective of this study was to establish safer cordocentesis by using newly produced 25-gauge needles rather than the needles currently used...
  88. ncbi Short-term continuous infusion of human parathyroid hormone 1-34 fragment is catabolic with decreased trabecular connectivity density accompanied by hypercalcemia in C57BL/J6 mice
    A Iida-Klein
    Regional Bone, Helen Hayes Hospital, West Haverstraw, New York 10993, USA
    J Endocrinol 186:549-57. 2005
    ..To do this we sought to create a model with short-term, sustained hyperparathyroidism using osmotic infusion pumps. We treated 10-week-old female C57BL/J6 mice with continuous infusion of hPTH1-34 (8.1 pmol/0...
  89. ncbi Implications of circadian clocks for the rhythmic delivery of cancer therapeutics
    Francis Levi
    INSERM, U776 Rythmes biologiques et cancers, Hopital Paul Brousse, Villejuif, F 94807, France
    Adv Drug Deliv Rev 59:1015-35. 2007
    ..Programmable-in-time infusion pumps and rhythmic physiology monitoring devices have made possible the application of chronotherapeutics to more ..
  90. ncbi Intrathecal catheter-syringe adaptor for short-term intrathecal analgesia with an externalized pump: a case report
    Denise Wilkes
    University of Texas Medical Branch, Galveston, Texas 77555, USA
    Pain Physician 13:151-6. 2010
    ..These are regular infusion pumps that the health care workers are familiar with so they can provide excellent and efficient service to the ..
  91. ncbi Total intravenous anesthesia as a target-controlled infusion. An evolutive analysis
    Fernando Squeff Nora
    Rev Bras Anestesiol 58:179-92. 2008
    ..1921) and thiopental (1934), TIVA has evolved until the development of TIVA with target-controlled infusion pumps (TCI). The first pharmacokinetic model for the use of TCI was described by Schwilden in 1981...
  92. ncbi Development of a peritoneal sclerosis rat model using a continuous-infusion pump
    Hirotaka Komatsu
    Department of Urology, Graduate School of Medicine, Yamaguchi University, Yamaguchi, Japan
    Perit Dial Int 28:641-7. 2008
    ..We therefore aimed to make a rat model using a continuous-infusion pump...
  93. ncbi Combined external and internal hospital disaster: impact and response in a Houston trauma center intensive care unit
    Joseph L Nates
    Vivian L Smith Center for Neurologic Research and the Department of Neurosurgery and Anesthesiology Critical Care, The University of Texas, Houston, TX, USA
    Crit Care Med 32:686-90. 2004
    ..To increase awareness of specific risks to healthcare systems during a natural or civil disaster. We describe the catastrophic disruption of essential services and the point-by-point response to the crisis in a major medical center...
  94. ncbi [Parenteral nutrition in neonatal units: a survey of current practices in Poland]
    Janusz Ksiazyk
    Klinika Pediatrii Instytut Pomnik Centrum Zdrowia Dziecka, 04 730 Warszawa
    Med Wieku Rozwoj 12:899-904. 2008
    ..The aim of the study was to assess parenteral nutrition methods in neonatal units in Poland...
  95. ncbi Operating manual-based usability evaluation of medical devices: an effective patient safety screening method
    James P Turley
    School of Health Information Sciences, University of Texas Health Science Center at Houston, USA
    Jt Comm J Qual Patient Saf 32:214-20. 2006
    ..A review of medical device operating manuals is proposed as a more practical method of usability evaluation...
  96. ncbi Intrathecal narcotic infusion pumps for intractable pain of chronic pancreatitis: a pilot series
    Pradermchai Kongkam
    Indiana University Medical Center, Indianapolis, Indiana 46202, USA
    Am J Gastroenterol 104:1249-55. 2009
    ..ITNP offers the advantages of reversibility, lower total narcotic dose, and the pancreas remaining intact...
  97. ncbi Gene therapy for spinal applications
    Chisa Hidaka
    Hospital for Special Surgery, Belfer Gene Therapy Core Facility, Weill Medical College of Cornell University, New York, NY, USA
    Orthop Clin North Am 33:439-46. 2002
    ..the high-level local production of growth factors, obviating the need for slow release carriers or continuous infusion pumps that are otherwise necessary because of the short half-lives of most peptide growth factors...
  98. ncbi Outcomes of posterior spinal fusion and instrumentation in patients with continuous intrathecal baclofen infusion pumps
    Michelle S Caird
    Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA
    Spine (Phila Pa 1976) 33:E94-9. 2008
    ....
  99. ncbi Changes in red blood cell integrity related to infusion pumps: a comparison of three different pump mechanisms
    Bernhard Frey
    Department of Intensive Care and Neonatology, University Children s Hospital Zurich, Zurich, Switzerland
    Pediatr Crit Care Med 4:465-70. 2003
    To study the effects of three different infusion pumps on red blood cell (RBC) integrity.
  100. ncbi Brain-derived neurotrophic factor gene transfer with adeno-associated viral and lentiviral vectors prevents rubrospinal neuronal atrophy and stimulates regeneration-associated gene expression after acute cervical spinal cord injury
    Brian K Kwon
    International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, British Columbia, Canada
    Spine (Phila Pa 1976) 32:1164-73. 2007
    ..Experimental animal study...

Research Grants64

  1. Implantable Minipump For Tetherless Drug Self-Administration In Mice
    DANIEL PHILIPP HOLSCHNEIDER; Fiscal Year: 2010
    ..to environmental manipulations, yet current preclinical models involve animals tethered to external mechanical infusion pumps and do not allow significant exploration of the effects of environmental factors on addictive behavior...
  2. Multifunction High Throughput System for Neurophysiology of Behavior
    DONALD JAY WOODWARD; Fiscal Year: 2012
    ..Installation of syringe infusion pumps on the unit that rotates with the animal is a novel design allowing for multiple fluid connections to and from ..
  3. Development of novel and stable glucagon formulations for closed loop systems
    Roderike Pohl; Fiscal Year: 2013
    ..of such a "closed loop" artificial pancreas algorithmically linking continuous glucose sensors with insulin infusion pumps is an active area of research...
  4. Wirelessly-operated Implantable MEMS Micropumps for Drug Infusion in Mice
    ELLIS MENG; Fiscal Year: 2013
    ..Continuous dosing is possible with external infusion pumps or implantable osmotic pumps...
  5. Aptamer-based Insulin Detection Device
    Ralph Ballerstadt; Fiscal Year: 2012
    ..assessment of insulin impairment in type II diabetics, and B) as feedback control for diabetics with insulin infusion pumps. The significance of this technology is based on the fact that diabetes, primarily type 2 diabetes, continues ..
  6. Improving Patient Safety Related to Medication Infusion Pump Technology using Sys
    Alan D Ravitz; Fiscal Year: 2013
    Abstract Clinicians, engineers, and medical care providers cite medication infusion pumps among the most problematic medical devices used today in the clinical setting...
  7. Understanding chemokine synergism in type 1 diabetes
    MARY PAUZA; Fiscal Year: 2004
    ..A complementary model system using osmotic infusion pumps will be developed to test the in vivo effects of various chemokine expression patterns on cell recruitment...
  8. COMMERCIALIZATION OF GRAPHICAL INTRAVENOUS DRUG DISPLAY
    Noah Syroid; Fiscal Year: 2005
    ..In Phase III, the graphical display technology will be integrated with drug infusion pumps and patient physiologic monitors.
  9. HEPATIC INSULIN GENE EXPRESSION IN IDDM
    Savio Woo; Fiscal Year: 2001
    ..be fatal, and alternative long-term strategies such as islet cell transplantation or implantation of insulin infusion pumps are currently under active investigation...
  10. LONG TERM CENTRIFUGAL VENTRICULAR ASSIST DEVICE
    ALAN MILLNER; Fiscal Year: 1990
    ..and very reliable, while not being limited to short term use by the shaft seal of presently used centrifugal infusion pumps. This device will be more compact and inherently simpler than valved pulsatile Ventricular Assist Devices...
  11. Mechanisms of Vascular Injury in the preterm lung
    Suhas Kallapur; Fiscal Year: 2006
    ..The experimental design in this proposal incorporates challenging but, particularly in this environment achievable goals that will provide important knowledge in the pathogenesis of bronchopulmonary dysplasia. ..
  12. Maturational changes in superficial zone chondrocytes
    Chisa Hidaka; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  13. Mechanistic bases for age-related androgen deficiency
    Johannes Veldhuis; Fiscal Year: 2007
    ..Knowing why testosterone falls should help foster new and safer ways to prevent the problem. [unreadable] [unreadable] [unreadable]..
  14. Nursing Home IT: Optimal Medication and Care Delivery
    Susan Horn; Fiscal Year: 2006
    ..Distill and summarize lessons learned about what is critical for successful implementation of HIT in nursing homes, including facilitators, barriers, and strategies to address them. ..
  15. Pain Mechanisms and the Development of Analgesics
    Tony Yaksh; Fiscal Year: 2006
    ..g. COX2 inhibitors, GABApentin, ziconotide) and failures (NK1 antagonist). [unreadable] [unreadable] [unreadable]..
  16. Development of a Novel Method for Inhibiting Atherosclerosis in Diabetes
    David Clemmons; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  17. Surfactant protein variants in pediatric lung injury
    Neal Thomas; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  18. PKCepsilon-Related Proteins in Lung Fibrosis
    Stanley Hoffman; Fiscal Year: 2006
    ..These approaches will allow us to validate the role in lung fibrosis of the several target proteins that we have already identified. ..
  19. MINORITY BASED COMMUNITY CLINICAL ONCOLOGY PROGRAM
    Peter Wiernik; Fiscal Year: 2006
    ..Efforts in screening and prevention intervention will be facilitated through the Community Outreach program and Community Council. ..
  20. Hybrid Drugs: Novel Pharmacotherapy for ADHD
    FRANK TARAZI; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  21. Analytical Reconstruction of Feedback Signaling in Aging Men
    Johannes Veldhuis; Fiscal Year: 2008
    ..The present proposal develops a general biomathematical framework for dissecting otherwise observed pathways that control hormone output in aging, stress and disease. [unreadable] [unreadable] [unreadable]..
  22. GENE THERAPY AND SEIZURES
    Thomas J McCown; Fiscal Year: 2011
    ..The present proposed studies will define the most efficacious adeno-associated virus vector which will provide a viable gene therapy treatment for intractable epilepsy. ..
  23. Design and Development of Pharmacotherapies for Treating Stimulant Abuse
    Frank Ivy Carroll; Fiscal Year: 2010
    ..3) To continue on a limited basis our development of selected 3-phenyltropane analogs as second-generation pharmacotherapies to treat cocaine addiction. ..
  24. Characterization of Toxicity with Spinal Opiates
    Tony L Yaksh; Fiscal Year: 2010
    ..The present studies aim to define the mechanisms of granuloma formation and point to specific methods to prevent granuloma formation, which will increase the utility and reduce the risks of this important pain therapy. ..
  25. NOVEL PHARMACOTHERAPY FOR TREATMENT OF COCAINE ADDICTION
    Frank Carroll; Fiscal Year: 2008
    ..abstract_text> ..
  26. Neuropharmacology of Learned Food Preferences
    Anthony Sclafani; Fiscal Year: 2009
    ..It will advance our understanding of the basic mechanisms involved in the development of food preferences and may provide insights into the clinical treatment of overeating and obesity. ..
  27. Reducing Sedative Exposure in Ventilated ICU Patients
    Linda Chlan; Fiscal Year: 2009
    ..abstract_text> ..
  28. Continuous Treatment with Oxalate Changes Renal Physiology and Morphology (DK0750
    Susan Ruth Marengo; Fiscal Year: 2008
    ..The objective is to identify those effects which promote these conditions. Future work will determine the mechanism of these effects with the goal of developing an effective preventative therapy. [unreadable] [unreadable] [unreadable]..
  29. Northeast Under/Grad Research Organization for Neuroscience
    Cheryl Frye; Fiscal Year: 2008
    ..Both of these outcomes are congruous with the Public Health Service's mission to ensure that there is a resource of well-trained scientists and health-care providers in the United States. [unreadable] [unreadable] [unreadable]..
  30. Hyperglycemia-Induced Mechanical Hyperalgesia
    Maxim Dobretsov; Fiscal Year: 2006
    ..abstract_text> ..
  31. Nicotinic-Antipsychotic Drug Interactions and Cognition
    Edward Levin; Fiscal Year: 2006
    ..abstract_text> ..
  32. NOVEL PHARMACOTHERAPIES FOR COCAINE DEPENDENCE
    Frank Carroll; Fiscal Year: 2001
    ..An ideal candidate compound would not only have efficacy in the preclinical models but would be safe, orally active, and potent, would not show tolerance or sensitization, and if abusable, would be less so than cocaine. ..
  33. PREVENTION OF STROKE DYSFUNCTION BY ACE INHIBITION
    CHARLES STIER; Fiscal Year: 2003
    ..abstract_text> ..
  34. MENTORED PATIENT ORIENTED RESEARCH CAREER DEVELOPMENT AW
    Linda DiMeglio; Fiscal Year: 2004
    ..We will characterize the changes effected by oral bisphosphonate therapy and compare them to a regimen of intravenous bisphosphonate therapy in a group of children with OI. ..
  35. DEPSIPEPTIDE: A NOVEL HISTONE DEACYTLASE INHIBITOR IN L
    John Byrd; Fiscal Year: 2003
    ..The clinical and laboratory results of this trial will provide pharmacokinetic and pharmacodynamic information for additional correlative efforts in both single agent phase II and combination phase I studies. ..
  36. Marine Toxin Impacts on Neurobehavioral Function
    Edward Levin; Fiscal Year: 2003
    ..The forum will provide an opportunity for methodological and theoretical issues to be integrated in the context of each talk as well as in a discussion session at the end of the symposium. ..
  37. Novel pharmacotherapies for treatment of ADHD
    FRANK TARAZI; Fiscal Year: 2003
    ..Expected findings should evolve new principles and lead to novel compounds that can be used as much-needed innovative treatments for ADHD and other major neuropsychiatric disorders. ..
  38. R21 Project: Curcumin Treatment of Fibrosis
    Stanley Hoffman; Fiscal Year: 2002
    ..These experiments will demonstrate the efficacy and the scientific basis for that efficacy of a disease treatment already recommended by practitioners of alternative medicine. ..
  39. Systems for intra-parenchymal therapy delivery
    Raghu Raghavan; Fiscal Year: 2004
    ..abstract_text> ..
  40. PAIN EVOKED RELEASE OF AMINO ACIDS AND PROSTANOIDS
    Tony Yaksh; Fiscal Year: 2005
    ....
  41. CELL GROWTH, NA/H EXCHANGE, AND CYCLINS IN IDDM PATIEN
    Daniel Batlle; Fiscal Year: 2002
    ....
  42. ARTHEROSCLEROSIS IN INSULIN-RESISTANT, HYPERLIPIDEMIC P*
    David Clemmons; Fiscal Year: 2005
    ....
  43. Epigenetic Targeted Therapy for Chronic Lymphocytic Leu*
    John Byrd; Fiscal Year: 2005
    ..abstract_text> ..
  44. Molecular Markers: Response to Chemo-immunotherapy in C*
    John Byrd; Fiscal Year: 2005
    ..Such therapy would potentially administer different types of chemoimmunotherapy based upon the presence or absence of IgVH mutational status and p53 dysfunction. ..
  45. Behavioral Genetics and Toxic Response
    Edward Levin; Fiscal Year: 2002
    ....
  46. BRAIN AND SPINAL CORD CONTRIBUTIONS TO ANESTHETIC ACTION
    JOSEPH ANTOGNINI; Fiscal Year: 2005
    ..This information will aid the development of newer and safer anesthetics, as well as lead to clinically useful means of modulating the neurotransmitter systems that are themselves modulated by anesthetics. ..
  47. Intracerebral Infusion of Radiolabeled Specific Antibody
    John Sampson; Fiscal Year: 2006
    ..abstract_text> ..
  48. New PET Radiotracers-Monoamine Transporters
    Michael Kilbourn; Fiscal Year: 2003
    ....
  49. PILOT TRIAL OF THALAMIC STIMULATION FOR EPILEPSY
    Robert Fisher; Fiscal Year: 2001
    ..A consortium of centers experienced in epilepsy research will collaborate on this project, which will move brain stimulation for epilepsy into the realm of a testable new therapy for intractable seizures. ..
  50. Improving Transfusion Practices Using Decision Support
    Jeffrey Rothschild; Fiscal Year: 2004
    ..We will also examine whether improvements in appropriate transfusion ordering behavior among clinicians using decision support tools will be greater than improvements achieved by educational programs alone. ..
  51. ACTIONS OF ESTROGEN IN MATURING GRAAFIAN FOLLICLES
    Johannes Veldhuis; Fiscal Year: 2005
    ..Understanding such fundamental interactions is important to the rational design of alternative strategies to interrupt normal and rescue impaired steroidogenesis in the maturing Graafian follicle and corpus luteum. ..
  52. Cortical Catheters
    Martin Brady; Fiscal Year: 2004
    ..In Phase II or subsequent efforts, we will test the predictions of the models and simulations based on the hypotheses developed here, and evaluate the performance of SCD neurocatheters in an appropriate animal model. ..
  53. THE AGING GH AXIS IN POSTMENOPAUSAL WOMEN
    Johannes Veldhuis; Fiscal Year: 2005
    ..An enhanced knowledge base should aid ultimately in formulating more innovative preventive and interventional strategies to limit hyposomatotropism in older and/or estrogen-deficient humans. ..
  54. Temporal Response of Dopamine to Alcohol Imaged via PET
    Evan Morris; Fiscal Year: 2007
    ..The methods to be developed will easily translate to human imaging studies. [unreadable] [unreadable] [unreadable]..
  55. Adolescence: A Sensitive Period for Nicotine Addiction
    Edward Levin; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  56. Norepinephrine Transporters: Targets for ADHD
    FRANK TARAZI; Fiscal Year: 2004
    ..Expected findings should lead to novel compounds that can be developed as much needed innovative non-stimulant treatments for ADHD and other major neuropsychiatric disorders. ..
  57. ACTION - A CHF Trial Investigating Outcomes of Exercise
    CHRISTOPHER O CONNOR; Fiscal Year: 2008
    ..The trial will take place over 5 years with an initial 6 months for planning, training, and implementation; 3 years of enrollment; 1 year of follow-up; and 6 months for close out, analysis, and presentation. ..
  58. Ensemble Disruption of the GnRH-LH-Testosterone Axis
    Johannes Veldhuis; Fiscal Year: 2007
    ..Expected corollary outcomes are enhanced diagnosis, assessment and management of more subtle pathophysiology of the male gonadal axis in puberty and adulthood. ..
  59. Oxalate & Crystal Renal Phenotypes: A Microarray Study
    Susan Ruth Marengo; Fiscal Year: 2003
    ..The long term objective of this work is to establish the mechanism of oxalate induced damage in the kidney. ..
  60. SPINAL CORD INJURY, METHYLPREDNISOLONE & P GLYCOPROTEIN
    CHRISTOPHER BERNARDS; Fiscal Year: 2002
    ..4. To determine whether increased spinal cord bioavailability of methylprednisolone decreases secondary damage following spinal cord injury. ..
  61. MENTORED PATIENT ORIENTED RESEARCH CAREER DEVELOPMENT AW
    John Sampson; Fiscal Year: 2004
    ....