Genomes and Genes
Summary: A measure of the quality of health care by assessment of unsuccessful results of management and procedures used in combating disease, in individual cases or series.
Publications287 found, 100 shown here
- Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association studyAndri Rauch
University Clinic of Infectious Diseases, University Hospital Bern and University of Bern, Bern, Switzerland
Gastroenterology 138:1338-45, 1345.e1-7. 2010..We performed a genome-wide association study to screen for host genetic determinants of HCV persistence and response to therapy...
- Second-line treatment in the Malawi antiretroviral programme: high early mortality, but good outcomes in survivors, despite extensive drug resistance at baselineM C Hosseinipour
University of North Carolina Project, Lilongwe, Malawi
HIV Med 11:510-8. 2010..Advanced disease progression may occur before switching to second-line ART. We report outcomes for patients evaluated and initiated on second-line treatment in Malawi...
- Low-frequency HIV-1 drug resistance mutations and risk of NNRTI-based antiretroviral treatment failure: a systematic review and pooled analysisJonathan Z Li
Section of Retroviral Therapeutics, Brigham and Women s Hospital, Harvard Medical School, Harvard University, Boston, Massachusetts 02139, USA
JAMA 305:1327-35. 2011....
- Unnecessary antiretroviral treatment switches and accumulation of HIV resistance mutations; two arguments for viral load monitoring in AfricaKim C E Sigaloff
PharmAccess Foundation, Amsterdam, The Netherlands
J Acquir Immune Defic Syndr 58:23-31. 2011..Frequencies of unnecessary switches, patterns of HIV drug resistance, and risk factors for the accumulation of nucleoside reverse transcriptase inhibitor (NRTI)-associated mutations were evaluated...
- High-level cefixime- and ceftriaxone-resistant Neisseria gonorrhoeae in France: novel penA mosaic allele in a successful international clone causes treatment failureMagnus Unemo
WHO Collaborating Centre for Gonorrhoea and Other STIs, Department of Laboratory Medicine, Microbiology, Orebro University Hospital, Orebro, Sweden
Antimicrob Agents Chemother 56:1273-80. 2012..with high-level cefixime and ceftriaxone resistance which was isolated in France and most likely caused a treatment failure with cefixime...
- Predictors of virologic failure and resistance in HIV-infected patients treated with nevirapine- or efavirenz-based antiretroviral therapyJean Jacques Parienti
Department of Infectious Diseases and Virology, Côte de Nacre Hospital, Caen, France
Clin Infect Dis 38:1311-6. 2004..8-180.3; P<.0001). Patients' previous adherence to therapy and drugs genetic barriers, not only the number of pills or doses involved, should be taken into consideration in the decision to simplify highly active antiretroviral therapy...
- Neisseria gonorrhoeae treatment failure and susceptibility to cefixime in Toronto, CanadaVanessa G Allen
Public Health Ontario Laboratories, 81 Resources Rd, Toronto, ON M9P 3T1, Canada
JAMA 309:163-70. 2013..Increased minimum inhibitory concentrations (MICs) to cefixime have been identified worldwide and have been associated with reports of clinical failure...
- Phenotypic and genetic characterization of the first two cases of extended-spectrum-cephalosporin-resistant Neisseria gonorrhoeae infection in South Africa and association with cefixime treatment failureDavid A Lewis
Centre for HIV and Sexually Transmitted Infections, National Institute for Communicable Diseases, National Health Laboratory Service, 1 Modderfontein Road, Sandringham 2192, South Africa
J Antimicrob Chemother 68:1267-70. 2013To describe the phenotypic and genetic characteristics of the first two cases of extended-spectrum cephalosporin (ESC)-resistant Neisseria gonorrhoeae in South Africa, one of which was associated with verified cefixime treatment failure.
- Safety and efficacy of simplified antibiotic regimens for outpatient treatment of serious infection in neonates and young infants 0-59 days of age in Bangladesh: design of a randomized controlled trialAbdullah H Baqui
Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Pediatr Infect Dis J 32:S12-8. 2013..Because access to care is limited in settings with high mortality, exclusive reliance on the current recommendation of 7-10 days of parenteral antibiotic treatment is a barrier to provision of adequate treatment of newborn infections...
- Accumulation of drug resistance and loss of therapeutic options precede commonly used criteria for treatment failure in HIV-1 subtype-C-infected patientsRoos E Barth
Department of Internal Medicine and Infectious Diseases, University Medical Centre Utrecht, Utrecht, The Netherlands
Antivir Ther 17:377-86. 2012..Here, accumulation of resistance and consequences for second-line therapy were investigated in African HIV-1 subtype-C-infected patients...
- Risk factors for tuberculosis treatment failure, default, or relapse and outcomes of retreatment in MoroccoKelly E Dooley
Johns Hopkins University School of Medicine, Baltimore, USA
BMC Public Health 11:140. 2011..In this study, we evaluated the risk factors for initial treatment failure, default, or early relapse leading to the need for tuberculosis retreatment in Morocco...
- The public health approach to identify antiretroviral therapy failure: high-level nucleoside reverse transcriptase inhibitor resistance among Malawians failing first-line antiretroviral therapyMina C Hosseinipour
University of North Carolina Project, Lilongwe, Malawi
AIDS 23:1127-34. 2009..We evaluated drug resistance patterns among patients failing first-line ART on the basis of clinical or immunological criteria in Lilongwe and Blantyre, Malawi...
- Efavirenz plasma levels can predict treatment failure and central nervous system side effects in HIV-1-infected patientsC Marzolini
Department of Medicine, University Hospital of Lausanne, Switzerland
AIDS 15:71-5. 2001..The aim of this study was to determine whether efavirenz plasma concentration monitoring could predict treatment failure and central nervous system (CNS) tolerability...
- Pre-existing minority drug-resistant HIV-1 variants, adherence, and risk of antiretroviral treatment failureRoger Paredes
Brigham and Women s Hospital, Harvard Medical School, Cambridge, MA 02139, USA
J Infect Dis 201:662-71. 2010..The clinical relevance of detecting minority drug-resistant human immunodeficiency virus type 1 (HIV-1) variants is uncertain...
- Treatment failure and resistance with direct-acting antiviral drugs against hepatitis C virusJean Michel Pawlotsky
Department of Virology, Hopital Henri Mondor, Université Paris Est Créteil, France
Hepatology 53:1742-51. 2011..This article reviews patterns of resistance to HCV DAA drugs in development, the mechanisms underlying treatment failure when these drugs are combined with pegylated interferon-α and ribavirin, the consequences of treatment ..
- Antiretroviral treatment of adult HIV infection: 2010 recommendations of the International AIDS Society-USA panelMelanie A Thompson
AIDS Research Consortium of Atlanta, Atlanta, Georgia, USA
JAMA 304:321-33. 2010....
- Treatment of nasopharyngeal carcinoma with intensity-modulated radiotherapy: the Hong Kong experienceMichael K M Kam
Clinical Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
Int J Radiat Oncol Biol Phys 60:1440-50. 2004..To evaluate the efficacy of using intensity-modulated radiotherapy (IMRT) in the primary treatment of nasopharyngeal carcinoma (NPC), including the role of dose escalation above 66 Gy level...
- Viremia and drug resistance among HIV-1 patients on antiretroviral treatment: a cross-sectional study in Soweto, South AfricaZiad El-Khatib
Division of Global Health IHCAR, Karolinska Institutet, Stockholm, Sweden
AIDS 24:1679-87. 2010..We assessed risk factors for viremia and drug resistance among long-term recipients of antiretroviral therapy (ART) in South Africa...
- Simplified antibiotic regimens for the management of clinically diagnosed severe infections in newborns and young infants in first-level facilities in Karachi, Pakistan: study design for an outpatient randomized controlled equivalence trialAnita K M Zaidi
Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan
Pediatr Infect Dis J 32:S19-25. 2013..Alternative, simpler antibiotic regimens that could be used in outpatient settings have the potential to save thousands of lives...
- Antidogmatic approaches to artemisinin resistance: reappraisal as treatment failure with artemisinin combination therapySanjeev Krishna
Centre for Infection and Immunity, Division of Clinical Sciences, St George s, University of London, Cranmer Terrace, London SW17 0RE, UK
Trends Parasitol 29:313-7. 2013..criteria for defining artemisinin resistance that are not currently being applied and suggests the term 'treatment failure of artemisinin combination therapy' (TFACT) as a more accurate description of most cases of 'artemisinin ..
- First report of Salmonella enterica serotype paratyphi A azithromycin resistance leading to treatment failureAoife Molloy
Department of Infectious Diseases, Addenbrooke s Hospital, Cambridge, United Kingdom
J Clin Microbiol 48:4655-7. 2010..Resistance to fluoroquinolones is common and leads to more frequent use of newer agents like azithromycin. We report the first case of azithromycin resistance and treatment failure in a patient with S. Paratyphi A infection.
- Repopulation of cancer cells during therapy: an important cause of treatment failureJohn J Kim
Department of Radiation Oncology, Princess Margaret Hospital and University of Toronto, 610 University Avenue, Toronto, ON M5G 2M9, Canada
Nat Rev Cancer 5:516-25. 2005..during the intervals between treatments and this process of repopulation is an important cause of treatment failure. Strategies developed to overcome repopulation have improved clinical outcomes, and now new strategies to ..
- Virological monitoring and resistance to first-line highly active antiretroviral therapy in adults infected with HIV-1 treated under WHO guidelines: a systematic review and meta-analysisRavindra K Gupta
UCL MRC Centre for Medical Molecular Virology, University College London Medical School, London, UK
Lancet Infect Dis 9:409-17. 2009..This Review highlights the need for cheap point-of-care viral-load tests to identify early viral failures and limit the emergence of resistance...
- Obesity is associated with worse peritoneal dialysis outcomes in the Australia and New Zealand patient populationsStephen P McDonald
Australia and New Zealand Dialysis and Transplant Registry, Adelaide, Australia
J Am Soc Nephrol 14:2894-901. 2003..Such patients should be closely monitored during PD and should be considered for early transfer to an alternative renal replacement therapy if difficulties are experienced...
- Switching to second-line antiretroviral therapy in resource-limited settings: comparison of programmes with and without viral load monitoringOlivia Keiser
Institute of Social and Preventive Medicine ISPM, University of Bern, Bern, Switzerland
AIDS 23:1867-74. 2009..We examined switching from nonnucleoside reverse transcriptase inhibitor (NNRTI)-based first-line regimens to protease inhibitor-based regimens in Africa, South America and Asia...
- Deep V3 sequencing for HIV type 1 tropism in treatment-naive patients: a reanalysis of the MERIT trial of maravirocLuke C Swenson
BC Centre for Excellence in HIV AIDS, Vancouver, British Columbia, Canada
Clin Infect Dis 53:732-42. 2011..Results were compared with those obtained using the Enhanced Sensitivity Trofile Assay (ESTA), which is widely used in clinical practice...
- TP53 disruptive mutations lead to head and neck cancer treatment failure through inhibition of radiation-induced senescenceHeath D Skinner
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Clin Cancer Res 18:290-300. 2012..In this study, we use a classification of TP53 mutation (disruptive vs. nondisruptive) and examine impact on clinical outcomes and radiation sensitivity...
- Second-line rescue therapy with levofloxacin after H. pylori treatment failure: a Spanish multicenter study of 300 patientsJavier P Gisbert
Hospital de la Princesa, Madrid
Am J Gastroenterol 103:71-6. 2008..Our aim was to evaluate the efficacy and tolerability of a triple second-line levofloxacin-based regimen in patients with H. pylori eradication failure...
- Treatment failure in children in a randomized clinical trial with 10 and 20 days of meglumine antimonate for cutaneous leishmaniasis due to Leishmania viannia speciesR Palacios
Centro Internacional de Entrenamiento e Investigaciones Medicas, Cali, Colombia
Am J Trop Med Hyg 64:187-93. 2001..Pathogenicity of infection and pharmacokinetics may affect the treatment response in children. New therapeutic alternatives should be evaluated in trials that include children and women...
- Misclassification of first-line antiretroviral treatment failure based on immunological monitoring of HIV infection in resource-limited settingsRami Kantor
Division of Infectious Diseases, Brown University, Providence, Rhode Island, USA
Clin Infect Dis 49:454-62. 2009..The early identification of first-line antiretroviral treatment failure is critical to prevent morbidity, mortality, and drug resistance...
- Serum albumin level predicts initial intravenous immunoglobulin treatment failure in Kawasaki diseaseHo Chang Kuo
Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center, Taiwan
Acta Paediatr 99:1578-83. 2010..However, many patients with KD still show poor response to initial IVIG treatment. This study was conducted to investigate the risk factors for initial IVIG treatment failure in KD.
- IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: results from a 24-week multicentre randomised placebo-controlled trialP Emery
Leeds Teaching Hospitals Trust, University of Leeds, Leeds, UK
Ann Rheum Dis 67:1516-23. 2008..The phase III RADIATE study examined the efficacy and safety of tocilizumab, an anti-IL-6 receptor monoclonal antibody in patients with rheumatoid arthritis (RA) refractory to tumour necrosis factor (TNF) antagonist therapy...
- The COMS randomized trial of iodine 125 brachytherapy for choroidal melanoma: IV. Local treatment failure and enucleation in the first 5 years after brachytherapy. COMS report no. 19Lee M Jampol
Department of Ophthalmology, Northwestern University Medical School, Chicago, Illinois, USA
Ophthalmology 109:2197-206. 2002To describe the frequency and predictors of local treatment failure and enucleation after iodine 125 (I(125)) brachytherapy in patients with choroidal melanoma treated and followed up in a large randomized clinical trial.
- The relationship of eosinophilia to intravenous immunoglobulin treatment failure in Kawasaki diseaseHo Chang Kuo
Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center, Kaohsiung, Taiwan
Pediatr Allergy Immunol 18:354-9. 2007..of eosinophils in Kawasaki disease (KD) and the relationship to initial intravenous immunoglobulin (IVIG) treatment failure. A retrospective analysis of all children who were admitted and met the criteria of KD between 1999 and 2005...
- Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study GroupR A DeFronzo
Diabetes Division, University of Texas Health Science Center, San Antonio, TX 78284, USA
N Engl J Med 333:541-9. 1995..Sulfonylurea drugs have been the only oral therapy available for patients with non-insulin-dependent diabetes mellitus (NIDDM) in the United States. Recently, however, metformin has been approved for the treatment of NIDDM...
- Pathological results and rates of treatment failure in high-risk prostate cancer patients after radical prostatectomyJochen Walz
Cancer Prognostics and Health Outcomes Unit, University of Montreal, Montreal, Canada
BJU Int 107:765-70. 2011..To investigate the pathological characteristics and the rates of biochemical recurrence (BCR) -free survival after radical prostatectomy (RP) in men with high-risk prostate cancer...
- Conservation of first-line antiretroviral treatment regimen where therapeutic options are limitedCatherine Orrell
The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, South Africa
Antivir Ther 12:83-8. 2007....
- Lopinavir/ritonavir monotherapy after virologic failure of first-line antiretroviral therapy in resource-limited settingsJohn A Bartlett
Duke University Medical Center, Durham, NC 27710, USA
AIDS 26:1345-54. 2012..To evaluate virologic response rates of lopinavir/ritonavir (LPV/r) monotherapy as second-line antiretroviral treatment (ART) among adults in resource-limited settings (RLSs)...
- Iron status predicts treatment failure and mortality in tuberculosis patients: a prospective cohort study from Dar es Salaam, TanzaniaSheila Isanaka
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America
PLoS ONE 7:e37350. 2012..The aim of the present analysis was to examine the association of iron status with the risk of TB progression and death...
- Natural killer inhibitory receptor expression associated with treatment failure and interleukin-28B genotype in patients with chronic hepatitis CLucy Golden-Mason
Division of Gastroenterology and Hepatology, Hepatitis C Center, Department of Medicine, University of Colorado Denver and National Jewish Hospital, Denver, CO, USA
Hepatology 54:1559-69. 2011....
- Limited impact of IL28B genotype on response rates in telaprevir-treated patients with prior treatment failureStanislas Pol
Universite Paris Descartes, INSERM Unité 1016, and Assistance Publique Hopitaux de Paris, Cochin Hospital, Paris, France
J Hepatol 58:883-9. 2013..This subanalysis of the REALIZE study evaluated the impact of IL28B polymorphisms on sustained virologic response (SVR) in telaprevir-treated, HCV genotype 1-infected patients with prior PegIFN/RBV treatment failure.
- Failure of immunologic criteria to appropriately identify antiretroviral treatment failure in UgandaSteven J Reynolds
National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA
AIDS 23:697-700. 2009..Our objective was to evaluate immunologic failure criteria against gold standard virologic monitoring...
- Emergence of drug resistance in HIV type 1-infected patients after receipt of first-line highly active antiretroviral therapy: a systematic review of clinical trialsRavindra Gupta
Division of Infection and Immunity, University College London, London, United Kingdom
Clin Infect Dis 47:712-22. 2008..Resistance to antiretroviral combination therapy is associated with increased mortality. Understanding the relative risks of emerging resistance to first-line therapy is of importance for both resource-rich and resource-poor settings...
- Outcome of high-risk myelodysplastic syndrome after azacitidine treatment failureThomas Prebet
Sidney Kimmel Cancer Center, Johns Hopkins University, Baltimore, MD, USA
J Clin Oncol 29:3322-7. 2011..ie, International Prognostic Scoring System high or intermediate 2) myelodysplastic syndrome (MDS), but most patients will experience primary or secondary treatment failure. The outcome of these patients has not yet been described.
- Long-term consequences of the delay between virologic failure of highly active antiretroviral therapy and regimen modificationMaya L Petersen
Division of Biostatistics, Berkeley School of Public Health, Berkeley, California 94720, USA
AIDS 22:2097-106. 2008..These recommendations have not been tested in observational studies or large randomized trials. We evaluated the consequences of delayed modification following virologic failure...
- Intracellular persistence of Staphylococcus aureus small-colony variants within keratinocytes: a cause for antibiotic treatment failure in a patient with darier's diseaseC von Eiff
Institute of Medical Microbiology, Westfalische Wilhelms Universitat Munster, Munster, Germany
Clin Infect Dis 32:1643-7. 2001..The presence of intracellular S. aureus SCVs may protect against host defenses and antibiotic therapy and thus may have contributed to this patient's very prolonged skin infection...
- Treatment failure and mortality factors in patients receiving second-line HIV therapy in resource-limited countriesMar Pujades-Rodriguez
Epicentre, Médecins Sans Frontières 42 bis, Bd, 8 rue Saint Sabin, 75011 Paris, France
JAMA 304:303-12. 2010..Limited access to further therapeutic options makes essential the evaluation of second-line regimen efficacy in these settings...
- Randomized phase II study of docetaxel and prednisone with or without OGX-011 in patients with metastatic castration-resistant prostate cancerKim N Chi
British Columbia Cancer Agency, Vancouver, British Columbia, Canada
J Clin Oncol 28:4247-54. 2010..To determine the clinical activity of OGX-011, an antisense inhibitor of clusterin, in combination with docetaxel/prednisone in patients with metastatic castration-resistant prostate cancer...
- Mucosal leishmaniasis: description of case management approaches and analysis of risk factors for treatment failure in a cohort of 140 patients in BrazilV S Amato
Infectious and Parasitic Diseases Clinic, Hospital das Clinicas, Medical School, University of Sao Paulo, Sao Paulo, Brazil
J Eur Acad Dermatol Venereol 23:1026-34. 2009..Mucosal leishmaniasis is caused mainly by Leishmania braziliensis and it occurs months or years after cutaneous lesions. This progressive disease destroys cartilages and osseous structures from face, pharynx and larynx...
- Antiretroviral therapies in women after single-dose nevirapine exposureShahin Lockman
Brigham and Women s Hospital, Boston, MA, USA
N Engl J Med 363:1499-509. 2010..Peripartum administration of single-dose nevirapine reduces mother-to-child transmission of human immunodeficiency virus type 1 (HIV-1) but selects for nevirapine-resistant virus...
- Treatment failure resulting from resistance of Staphylococcus aureus to daptomycinDaniel J Skiest
Baystate Medical Center, Division of Infectious Diseases, 759 Chestnut St, Springfield, MA 01199, USA
J Clin Microbiol 44:655-6. 2006..Clinicians should be aware of the possibility of daptomycin resistance and should consider routine testing for daptomycin susceptibility...
- FDG-PET after two cycles of chemotherapy predicts treatment failure and progression-free survival in Hodgkin lymphomaMartin Hutchings
PET and Cyclotron Unit, Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital, 9, Blegdamsvej, DK 2100 Copenhagen Ø, Denmark
Blood 107:52-9. 2006..Early interim FDG-PET is a strong and independent predictor of PFS in HL. A positive early interim FDG-PET is highly predictive of progression in patients with advanced-stage or extranodal disease...
- Highest clinical effectiveness of rituximab in autoantibody-positive patients with rheumatoid arthritis and in those for whom no more than one previous TNF antagonist has failed: pooled data from 10 European registriesKaterina Chatzidionysiou
Department of Rheumatology, Karolinska University Hospital, Stockholm, Sweden
Ann Rheum Dis 70:1575-80. 2011..To assess the 6-month effectiveness of the first rituximab (RTX) course in rheumatoid arthritis (RA) and to identify possible predictors of response...
- Outcomes after virologic failure of first-line ART in South AfricaRichard A Murphy
Operational Support Unit, Doctors Without Borders, New York, New York 10001, USA
AIDS 24:1007-12. 2010..To determine initial 24-week outcomes among prospectively enrolled patients with failure of initial antiretroviral therapy (ART)...
- Low-frequency K103N strengthens the impact of transmitted drug resistance on virologic responses to first-line efavirenz or nevirapine-based highly active antiretroviral therapyAnna Maria Geretti
Department of Virology, Royal Free Hampstead NHS Trust, London, UK
J Acquir Immune Defic Syndr 52:569-73. 2009..There are conflicting data on the impact of low-frequency transmitted drug-resistant mutants on responses to first-line highly active antiretroviral therapy (HAART)...
- Diagnosis of antiretroviral therapy failure in Malawi: poor performance of clinical and immunological WHO criteriaJoep J G van Oosterhout
Department of Medicine, University of Malawi College of Medicine, Blantyre, Malawi
Trop Med Int Health 14:856-61. 2009..We wanted to study the impact of only using clinical and immunological monitoring on the diagnosis of virological ART failure under routine circumstances...
- Low level of the K103N HIV-1 above a threshold is associated with virological failure in treatment-naive individuals undergoing efavirenz-containing therapyDerrick D Goodman
Gilead Sciences Inc, Durham, North Carolina, USA
AIDS 25:325-33. 2011..Here, we analyzed whether the presence of low levels of K103N at baseline correlated with virologic failure...
- Which subgroup of patients with rheumatoid arthritis benefits from switching to rituximab versus alternative anti-tumour necrosis factor (TNF) agents after previous failure of an anti-TNF agent?A Finckh
University Hospital of Geneva, Switzerland
Ann Rheum Dis 69:387-93. 2010..It remains unclear in which clinical settings these therapeutic strategies offer most benefit...
- Mycobacterium tuberculosis Beijing genotype is an independent risk factor for tuberculosis treatment failure in IndonesiaIda Parwati
Department of Clinical Pathology, Hasan Sadikin Hospital, Medical Faculty, Universitas Padjadjaran, Bandung, Indonesia
J Infect Dis 201:553-7. 2010..We examined whether Beijing strains increase treatment failure in a prospective cohort study in Indonesia...
- Mortality after failure of antiretroviral therapy in sub-Saharan AfricaOlivia Keiser
Institute of Social and Preventive Medicine ISPM, University of Bern, Bern, Switzerland
Trop Med Int Health 15:251-8. 2010To assess the outcome of patients who experienced treatment failure with antiretrovirals in sub-Saharan Africa.
- Risk factors associated with default, failure and death among tuberculosis patients treated in a DOTS programme in Tiruvallur District, South India, 2000T Santha
Tuberculosis Research Centre, Chetput, Chennai, India
Int J Tuberc Lung Dis 6:780-8. 2002..To identify risk factors associated with default, failure and death among tuberculosis patients treated in a newly implemented DOTS programme in South India...
- Ambulatory short-course high-dose oral amoxicillin for treatment of severe pneumonia in children: a randomised equivalency trialTabish Hazir
Children s Hospital, Pakistan Institute of Medical Sciences, Islamabad, Pakistan
Lancet 371:49-56. 2008..Our aim was to determine whether home treatment with high-dose oral amoxicillin and inpatient treatment with parenteral ampicillin were equivalent for the treatment of severe pneumonia in children...
- Resistance to antimony and treatment failure in human Leishmania (Viannia) infectionRicardo Rojas
Centro Internacional de Entrenamiento e Investigaciones Medicas, Cali, Colombia, and Centre Hospitalier Universitaire Laval, Quebec, Canada
J Infect Dis 193:1375-83. 2006..The role of drug resistance in treatment failure has been difficult to ascertain because therapeutic response is multifactorial, and the efficacy of ..
- A review of the virological efficacy of the 4 World Health Organization-recommended tenofovir-containing regimens for initial HIV therapyMichele W Tang
Department of Medicine, Division of Infectious Diseases, Stanford University, California 94305 5107, USA
Clin Infect Dis 54:862-75. 2012..Further study of TDF/3TC/NVP is required before it is widely deployed for initial ARV therapy...
- Virologic failure of protease inhibitor-based second-line antiretroviral therapy without resistance in a large HIV treatment program in South AfricaJulie H Levison
Division of General Medicine Massachusetts General Hospital, Boston, Massachusetts, United States of America
PLoS ONE 7:e32144. 2012..We investigated the prevalence of wild-type virus (no major drug resistance) and drug resistance mutations at second-line antiretroviral treatment (ART) failure in a large HIV treatment program in South Africa...
- The cost-effectiveness of spinal cord stimulation in the treatment of failed back surgery syndromeRod S Taylor
Peninsula Medical School, Universities of Exeter and Plymouth, UK
Clin J Pain 26:463-9. 2010..We present previously unavailable details of the National Institute of Health and Clinical Excellence analysis and an analysis of the impact on SCS cost effectiveness of rechargeable implanted pulse generators (IPGs)...
- Treatment failure among Kenyan children with severe pneumonia--a cohort studyClare Webb
Kenya Medical Research Institute KEMRI, Centre for Geographic Medicine Research, Kilifi, Kenya
Pediatr Infect Dis J 31:e152-7. 2012Pneumonia is the leading cause of childhood mortality worldwide. The World Health Organization recommends presumptive treatment based on clinical syndromes. Recent studies raise concerns over the frequency of treatment failure in Africa.
- Association of corticosteroid dose and route of administration with risk of treatment failure in acute exacerbation of chronic obstructive pulmonary diseasePeter K Lindenauer
Center for Quality of Care Research, Baystate Medical Center, 759 Chestnut St, Springfield, MA 01199, USA
JAMA 303:2359-67. 2010..Systemic corticosteroids are beneficial for patients hospitalized with acute exacerbation of chronic obstructive pulmonary disease (COPD); however, their optimal dose and route of administration are uncertain...
- Association between smoking status, other factors and tuberculosis treatment failure in MoroccoN Tachfouti
Laboratory of Epidemiology, Clinical Research and Community Health, Faculty of Medicine, Fez, Morocco
Int J Tuberc Lung Dis 15:838-43. 2011The association between smoking and tuberculosis (TB) treatment failure has not yet been assessed in Morocco.
- The phenomenon of treatment failures in Human African TrypanosomiasisR Brun
Swiss Tropical Institute, Basel, Switzerland
Trop Med Int Health 6:906-14. 2001..In conclusion, a combination of factors rather than a single one may be responsible for the phenomenon of melarsoprol treatment failures in T. b. gambiense patients...
- The clinical and economic impact of genotype testing at first-line antiretroviral therapy failure for HIV-infected patients in South AfricaJulie H Levison
Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA
Clin Infect Dis 56:587-97. 2013..After adherence counseling, these patients may safely and effectively continue first-line ART, thereby delaying more expensive second-line ART...
- Dentinal tubule infection as the cause of recurrent disease and late endodontic treatment failure: a case reportAdalberto R Vieira
Brazilian Association of Dentistry, Juiz de Fora, Minas Gerais, Brazil
J Endod 38:250-4. 2012..This article describes a case of recurrent post-treatment apical periodontitis and late failure after endodontic retreatment performed in a single visit...
- Early surgical ligation versus a conservative approach for management of patent ductus arteriosus that fails to close after indomethacin treatmentNami Jhaveri
Department of Pediatrics, University of California, San Francisco, CA 94143 0544, USA
J Pediatr 157:381-7, 387.e1. 2010..To examine whether a more conservative approach to treating patent ductus arteriosus (PDA) is associated with an increase or decrease in morbidity compared with an approach involving early PDA ligation...
- Treatment outcomes of patients on second-line antiretroviral therapy in resource-limited settings: a systematic review and meta-analysisOlawale Ajose
Clinton Health Access Initiative, Dar es Salaam, Tanzania
AIDS 26:929-38. 2012..We carried out a systematic review in order to summarize reported rates and reasons for virological failure among people on second-line therapy in resource-limited settings...
- Comparative genome sequencing of an isogenic pair of USA800 clinical methicillin-resistant Staphylococcus aureus isolates obtained before and after daptomycin treatment failureSusan Boyle-Vavra
Department of Pediatrics, University of Chicago, KCBD 4152, 900 E 57th Street, Chicago, IL 60657, USA
Antimicrob Agents Chemother 55:2018-25. 2011We describe here a clinical daptomycin treatment failure in a patient with recurrent methicillin-resistant Staphylococcus aureus (MRSA) bacteremia in whom daptomycin was administered after a failed empirical treatment course with ..
- Monitoring of highly active antiretroviral therapy in HIV infectionA Sarah Walker
MRC Clinical Trials Unit, London, UK
Curr Opin Infect Dis 24:27-33. 2011..We review studies describing the outcomes and costs of different monitoring approaches, predominantly in low-income countries...
- Maraviroc for previously treated patients with R5 HIV-1 infectionRoy M Gulick
Weill Cornell Medical College, New York, NY 10065, USA
N Engl J Med 359:1429-41. 2008..CC chemokine receptor 5 antagonists are a new class of antiretroviral agents...
- Meta-analysis: re-treatment of genotype I hepatitis C nonresponders and relapsers after failing interferon and ribavirin combination therapyA G Singal
University of Michigan Medical Center, Ann Arbor, USA
Aliment Pharmacol Ther 32:969-83. 2010..The efficacy of re-treating genotype I hepatitis C virus (HCV) patients who failed combination therapy with interferon/pegylated interferon (PEG-IFN) and ribavirin remains unclear...
- The Mycobacterium tuberculosis Beijing genotype does not affect tuberculosis treatment failure in VietnamTran N Buu
Pham Ngoc Thach Tuberculosis and Lung Disease Hospital, Ho Chi Minh City, Vietnam
Clin Infect Dis 51:879-86. 2010..that the Mycobacterium tuberculosis Beijing genotype causes more severe clinical disease and higher treatment failure rates with standard regimens, possibly in association with an increased risk of acquiring drug resistance...
- Mapping and characterization of vicriviroc resistance mutations from HIV-1 isolated from treatment-experienced subjects enrolled in a phase II study (VICTOR-E1)Paul M McNicholas
Department of Infectious Diseases, Merck Research Labs, Kenilworth, NJ 07033, USA
J Acquir Immune Defic Syndr 56:222-9. 2011..Among the 79 VCV-treated subjects, 15 experienced virologic failure, and of these 5 had VCV-resistant virus. This study investigated the molecular basis for the changes in susceptibility to VCV in these subjects...
- Absence of biallelic TCRgamma deletion predicts early treatment failure in pediatric T-cell acute lymphoblastic leukemiaAlejandro Gutierrez
Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
J Clin Oncol 28:3816-23. 2010..To identify children with T-cell acute lymphoblastic leukemia (T-ALL) at high risk of induction chemotherapy failure by using DNA copy number analysis of leukemic cells collected at diagnosis...
- Aetiology of root canal treatment failure: why well-treated teeth can failJ F Siqueira
Department of Endodontics, School of Dentistry, Estacio de Sa University, Rio de Janeiro, RJ, Brazil
Int Endod J 34:1-10. 2001..The purpose of this paper is to discuss the aetiology of the failure of root canal treatment, particularly in cases of well-treated root canals. Indications for the treatment of endodontic failures are also discussed...
- Associations with virologic treatment failure in adults on antiretroviral therapy in South AfricaMohammed Ishaaq Datay
Department of Primary Health Care, University of Oxford, Oxford, UK
J Acquir Immune Defic Syndr 54:489-95. 2010Highly active antiretroviral therapy (HAART) has been available in government facilities in the Western Cape Province of South Africa since 2001. We aimed to investigate factors associated with virologic treatment failure in this setting.
- Influence of multidrug resistance on tuberculosis treatment outcomes with standardized regimensAnton Mak
Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute, McGill University, Montreal, Canada
Am J Respir Crit Care Med 178:306-12. 2008..Multidrug-resistant tuberculosis (TB) poses a major challenge to global TB control. We analyzed the association between estimated prevalence of initial or acquired MDR-TB, and treatment outcomes reported nationally...
- Early and late complications associated with transcatheter occlusion of secundum atrial septal defectMassimo Chessa
Pediatric Cardiology, Istituto Policlinico San Donato, San Donato Milanese, Italy
J Am Coll Cardiol 39:1061-5. 2002..The goal of this study was to report the early and late complications experienced in atrial septal defect (ASD) transcatheter closure...
- Early adherence to antiretroviral medication as a predictor of long-term HIV virological suppression: five-year follow up of an observational cohortNathan Ford
Medecins Sans Frontieres, Cape Town, South Africa
PLoS ONE 5:e10460. 2010..Previous studies have demonstrated a cross-sectional relationship between antiretroviral adherence and HIV virological suppression. We assessed the predictive value of baseline adherence in determining long-term virological failure...
- Defining treatment failure in resource-rich settingsJeannette L Aldous
University of California San Diego, Department of Medicine, Division of Infectious Diseases, Antiretroviral Research Center AVRC, San Diego, California 92103, USA
Curr Opin HIV AIDS 4:459-66. 2009To define treatment failure in resource-rich settings; summarizing current guidelines, assays, the significance of detectable viremia, and definitions of treatment failure in clinical and research settings.
- Varied patterns of HIV-1 drug resistance on failing first-line antiretroviral therapy in South AfricaCarole L Wallis
Department of Molecular Medicine and Haematology, University of the Witwatersrand, Johannesburg, South Africa
J Acquir Immune Defic Syndr 53:480-4. 2010..HIV-1 drug resistance is a potential consequence of therapy. This study determined the pattern of HIV-1 drug resistance mutations after failure of first-line treatment regimens in South Africa...
- Limited value of CA 19-9 in predicting early treatment failure in patients with advanced pancreatic cancerLaurenz Vormittag
Division of Clinical Oncology, Department of Medicine I and Cancer Center, Medical University Vienna, Vienna, Austria
Oncology 77:140-6. 2009..The role of CA 19-9 in monitoring treatment response in advanced pancreatic cancer remains uncertain. We assessed its value in predicting early failure of first-line chemotherapy...
- Clinical and parasite species risk factors for pentavalent antimonial treatment failure in cutaneous leishmaniasis in PeruAlejandro Llanos-Cuentas
Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru
Clin Infect Dis 46:223-31. 2008..Knowledge of factors influencing treatment outcome is essential for successful management...
- Efficacy and safety of nevirapine extended-release once daily versus nevirapine immediate-release twice-daily in treatment-naive HIV-1-infected patientsJoseph Gathe
Therapeutic Concepts, Houston, Texas, USA
Antivir Ther 16:759-69. 2011..This study (VERxVE) compared the efficacy and safety of the new nevirapine extended-release (NVP XR) formulation dosed once daily with NVP immediate release (IR) twice daily in treatment-naive patients...
- Risk factors for treatment failure after melarsoprol for Trypanosoma brucei gambiense trypanosomiasis in UgandaD Legros
Epicentre, Kampala, Uganda
Trans R Soc Trop Med Hyg 93:439-42. 1999We evaluated the treatment failure rate among late-stage human African trypanosomiasis (HAT) patients treated with melarsoprol in Arua, northern Uganda, between September 1995 and August 1996, and identified the risk factors for ..
- Liver steatosis is an independent risk factor for treatment failure in patients with chronic hepatitis CKonstantinos C Thomopoulos
Department of Internal Medicine, University Hospital, Patras, Greece
Eur J Gastroenterol Hepatol 17:149-53. 2005..The purpose of this study was to determine factors related to the presence of steatosis and to define the role of steatosis in the response to antiviral treatment in chronic hepatitis C patients...
- Cementless modular hip arthroplasty as a salvage operation for failed internal fixation of trochanteric fractures in elderly patientsJean Michel Laffosse
Service de chirurgie orthopédique et de traumatologie, CHU Rangueil et CHU Purpan, Toulouse, France
Acta Orthop Belg 73:729-36. 2007..Primary arthroplasty with such an implant could be considered in selected cases such as markedly unstable fractures and in osteoporotic elderly patients...
- Baseline genotype as a predictor of virological failure to emtricitabine or stavudine in combination with didanosine and efavirenzKatyna Borroto-Esoda
Gilead Sciences, Inc, 4611 University Drive, Durham, North Carolina 27707, USA
AIDS Res Hum Retroviruses 23:988-95. 2007....
- Ovarian cancer: strategies for overcoming resistance to chemotherapyRoshan Agarwal
Section of Medicine, Institute for Cancer Research, Sutton, Surrey SM2 5NG, UK
Nat Rev Cancer 3:502-16. 2003..A better understanding of the mechanisms that underlie this drug resistance should allow treatment to be optimized, so that substantial improvements in the outlook for women with this disease can be achieved...
- Diagnosis and management of antiretroviral-therapy failure in resource-limited settings in sub-Saharan Africa: challenges and perspectivesAnthony D Harries
International Union Against Tuberculosis and Lung Disease, Paris, France
Lancet Infect Dis 10:60-5. 2010....
- Tumor necrosis factor (TNF) system levels in human immunodeficiency virus-infected patients during highly active antiretroviral therapy: persistent TNF activation is associated with virologic and immunologic treatment failureP Aukrust
Section of Clinical Immunology, Research Institute of Nuclear Medicine, Oslo, Norway
J Infect Dis 179:74-82. 1999..Patients with virologic and immunologic treatment failure after 52 weeks had higher levels of several TNF components than other patients early after initiation of ..
- A single dose of erythropoietin in ST-elevation myocardial infarctionAdriaan A Voors
Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
Eur Heart J 31:2593-600. 2010..032). Conclusion A single high dose of EPO after a successful PCI for a STEMI did not improve LVEF after 6 weeks. However, the use of EPO was related to less major adverse cardiovascular events and a favourable clinical safety profile...
- Frequency and evolution of Azole resistance in Aspergillus fumigatus associated with treatment failureSusan J Howard
Regional Mycology Laboratory, Manchester, UK
Emerg Infect Dis 15:1068-76. 2009..Azole resistance in A. fumigatus is an emerging problem and may develop during azole therapy...
- A Community Collaboration to Increase HIV Serostatus Awareness for At Risk AA MSMMelanie Thompson; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Treatment with Exercise Augmentation for DepressionMadhukar Trivedi; Fiscal Year: 2006....
- CARE Network-UCSD Clinical CenterRobert Zeiger; Fiscal Year: 2008..abstract_text> ..
- REVAMP Follow-UpMadhukar Trivedi; Fiscal Year: 2008....
- ESTIMATING EFFICACY OF A MEDICAL INTERVENTIONJames Trussell; Fiscal Year: 2001....
- Inflammation and Insulin Resistance in PADMark Creager; Fiscal Year: 2007..It is anticipated that the findings from this investigation will uncover novel pathophysiologic mechanisms and foster a new paradigm for the treatment of PAD. ..
- 2007 Atherosclerosis Gordon Research ConferenceMichael Rosenfeld; Fiscal Year: 2007..The [unreadable] conference will provide a comprehensive overview of current research on [unreadable] atherosclerosis with a focus on the latest and most exciting developments in the field. [unreadable] [unreadable] [unreadable]..
- Diesel Exhaust and Atherosclerotic Plaque StabilityMichael Rosenfeld; Fiscal Year: 2007....
- Real-time Minimal Residual Disease assay of Pediatric B-Cell Non-Hodgkin LymphomaBruce Shiramizu; Fiscal Year: 2007..The assay developed by this exploratory proposal could be incorporated into pediatric B-cell NHL studies to assess MRD on therapy or to assess the efficacy of innovative therapies. [unreadable] [unreadable] [unreadable]..
- SPAN-Xb as an immunologic target for CMLSEAH LIM; Fiscal Year: 2007..Successful completion of the proposal will therefore provide the basis for the clinical translation of SPAN-Xb. [unreadable] [unreadable]..
- Glutathione, macrophages and unstable atherosclerosisMichael Rosenfeld; Fiscal Year: 2007..abstract_text> ..
- Brief Focused Treatment for TMD: Mechanisms of ActionMark Litt; Fiscal Year: 2007..abstract_text> ..
- Computerized Decision Support System for DepressionMadhukar Trivedi; Fiscal Year: 2007..Comparisons will be made between CDSS-D, PPA-D, and UC-D. [unreadable] [unreadable]..
- Early Randomized Surgical Epilepsy TrialJerome Engel; Fiscal Year: 2007..abstract_text> ..
- ADULT AIDS CLINICAL TRIALS UNITJohn Bartlett; Fiscal Year: 2006..The applicants anticipate that Duke will continue as an efficient, cost-effective ACTU that contributes to the ACTG scientific agenda. ..
- Morphine versus Methadone as First Line Strong Opioid for Cancer PainEduardo Bruera; Fiscal Year: 2009..and opioid metabolite accumulation will result in less frequent opioid induced toxicity, dose escalation and treatment failure, and therefore, improved quality of life...
- TREATMENT OF SSRI-RESISTANT DEPRESSION IN ADOLESCENTSGraham Emslie; Fiscal Year: 2006..This site is based in Pittsburgh, which also serves as the Data Coordinating Center for the study [unreadable] [unreadable]..
- Treatment of Adolescent Suicide Attempters in DallasGraham Emslie; Fiscal Year: 2006..This exemplary protocol stimulated the formation of a collaborative group of 8 RUPP-PI applicants. By creating the protocol, the group forged an ability to work together. ..
- MECHANISMS OF SMOOTH MUSCLE HYPERREACTIVITY ON ASTHMAPrescott Woodruff; Fiscal Year: 2006..The candidate will complement these studies with a curriculum of advanced training in methods for the design and analysis of gene expression studies in human subjects. ..
- International Clinical Trials UnitJohn Bartlett; Fiscal Year: 2007..unreadable] [unreadable]..
- Clinical Activity of 17-AAG in LymphomaAnas Younes; Fiscal Year: 2007..In Aim 3 we will correlate the biologic effects of 17-AAG and clinical response in patients with relapsed MCL, ALCL, and HL. [unreadable] [unreadable] [unreadable]..
- Using MEPS Data to Inform Public-Plan ConsumerismMatthew Davis; Fiscal Year: 2007..Findings will have immediate relevance for implementation of the HOA projects and other consumerism efforts. [unreadable] [unreadable] [unreadable]..
- Structure-function of inositol trisphosphate receptorIlya Bezprozvanny; Fiscal Year: 2009..Dopamine-induced responses in striatal medium spiny neurons will be studied by Ca2+ imaging. Experiments with striatal neurons from DARPP-32 and D2 receptor knockout mice will be performed. ..
- Meta-analysis of GWAS data to identify novel rheumatoid arthritis risk lociRobert M Plenge; Fiscal Year: 2010..In addition, genetics should provide insight into important steps of the disease pathway, allowing for the development of new therapies that target these pathways in at-risk individuals. ..
- STATISTICAL PROBLEMS IN MULTIVARIATE SURVIVAL ANALYSISJianwen Cai; Fiscal Year: 2010..This research will provide valuable new tools to cardiovascular disease researchers and other biomedical researchers. It will help the researchers to better understand the risk factors associated with cardiovascular diseases. ..
- Targeting Inflammation to Improve Endothelial Function in Type 2 Diabetes: A SubsMark A Creager; Fiscal Year: 2010..End of Abstract) ..
- HTS Screen for Small Molecule Inhibitors of Mint-PDZ DomainIlya Bezprozvanny; Fiscal Year: 2008..Generated molecules may also serve as useful probes for studies of synaptic function of N-type Ca2+ channels. [unreadable] [unreadable] [unreadable]..
- MOLECULAR BASIS OF HIGH DENSITY LIPOPROTEIN DEFICIENCYERNST SCHAEFER; Fiscal Year: 2009..The results of this work will provide important insight into the contribution of allelic variation in the pathways of HDL metabolism, inflammation, and insulin resistance to the complex phenotype of low HDL-C. ..
- Presenilins and neuronal calcium signalingILYA B BEZPROZVANNY; Fiscal Year: 2010..These data will also help to evaluate "Ca2+ hypothesis of AD" and will contribute to selecting optimal strategies for treatment of AD. ..
- Combined Pharmacotherapies for Cocaine DependenceFrances Levin; Fiscal Year: 2008..3. To explore a set of related secondary outcomes (treatment retention, global functioning, and HIV risk behavior) as well as moderators and mediators potentially reflective of mechanism of action. [unreadable] [unreadable] [unreadable]..
- Cleveland Clinic Orthopaedic Research Training GrantJOSEPH IANNOTTI; Fiscal Year: 2008..abstract_text> ..
- Modifiers of Cancer Risk in BRCA 1/2 Mutation CarriersTimothy Rebbeck; Fiscal Year: 2008..Our substantial multidisciplinary experience will therefore allow us to readily translate basic science and epidemiological data to clinically relevant information. ..
- Targeting HIF-1alpha in renal cell carcinoma: the role of HDAC inhibitorsRoberto Pili; Fiscal Year: 2010....
- Phase II Clinical Trial Utilizing Lithium for Patients with Neuroendocrine TumorsHerbert Chen; Fiscal Year: 2008..Besides surgery, there are limited curative and palliative treatments available to patients with metastatic NE tumors, emphasizing the need for development of other forms of therapy. [unreadable] [unreadable] [unreadable]..
- Long-term efficacy of pediatric HAARTDALTON CHEKOKO WAMALWA; Fiscal Year: 2010..This study will provide important information on effectiveness of HAART regimens being scaled up in resource-poor countries and help programs better plan for changes of drug regimens following treatment failure.
- Mapping HIV/AIDS genes with haplotype-based strategiesRobert Plenge; Fiscal Year: 2008..These studies hope to identify novel genes that influence susceptibility to HIV/AIDS, thereby providing insight into HIV/AIDS pathogenesis and, ultimately, improving patient care. ..
- Dietary Omega-3 Fatty Acids and Sudden Cardiac DeathGEORGE EDWARD BILLMAN; Fiscal Year: 2010..This project will also determine the effectiveness of fish oil supplements in reducing sudden death due to a lethal abnormal heart rhythm after a heart attack. ..
- DIETARY COMPOSITION, OBESITY, AND CARDIOVASCULAR RISKERNST SCHAEFER; Fiscal Year: 2003..abstract_text> ..
- 1H MRSI OF AMYOTROPHIC LATERAL SCLEROSISMichael Weiner; Fiscal Year: 2002..abstract_text> ..
- Screen:Blockers of a CaV2.2-Mint-PDZ1 association (RMI)Ilya Bezprozvanny; Fiscal Year: 2004..Biological activity of compounds identified in the full HTS screen will be tested in whole animal pain assays (formalin, hot plate, tail flick). ..
- Marijuana Abusing ADHD Teens: Atomoxetine TreatmentFrances Levin; Fiscal Year: 2004..4. To examine the relationship between medication treatment, reduction in ADHD symptoms, and improvement in retention and/or progress in treatment using mediational analyses. ..
- Characteristics and Costs of Impaired Fasting GlucoseGregory Nichols; Fiscal Year: 2005..Finally, we will calculate and compare the costs of medical care for patients in each FPG stage, and estimate multivariate models to identify factors that contribute to medical costs in each stage. ..
- Clinical Approaches to Ileal Pouch DysfunctionBo Shen; Fiscal Year: 2005..The AIMS of study are to 1) investigate visceral hypersensitivity using barostat examination of the pouch; 2) conduct a randomized, placebo-controlled clinical trial evaluating the use of amitriptyline in IPS. ..
- METHYLPHENIDATE TREATMENT FOR COCAINE ABUSE AND ADHDFrances Levin; Fiscal Year: 2002..2) To determine if sustained-release MPH is more effective than placebo in reducing ADHD symptoms in cocaine abusers with adult ADHD. 3) To determine if improvement in ADHD symptoms precedes a reduction in cocaine use. ..
- Cardiac-Related Mortality with Atypical AntipsychoticsDEANNA KELLY; Fiscal Year: 2005..This study is important as data on long-term health outcomes with atypical antipsychotics is lacking from the literature. ..
- Role of Somatostatin Receptors in Pancreatic CancerWilliam Fisher; Fiscal Year: 2003..Since somatostatin expression has been demonstrated in other tumor types, the findings may also be relevant to other cancers. ..
- Role of Glycogen Synthase Kinase 3 In Type 2-DiabetesRobert Henry; Fiscal Year: 2004..abstract_text> ..
- RESPIRATORY DISEASES/BSI STUDYShahin Lockman; Fiscal Year: 2004....
- K24 MID-CAREER CLINICAL INVESTIGATOR AWARDJohn Bartlett; Fiscal Year: 2004..His immediate research objectives include the investigation of antiretroviral treatment failure, and efforts to diminish the reservoir of chronically HIV-infected cells in persons receiving antiretroviral ..
- Signaling Pathways in Hepatic FibrogenesisBruce Bacon; Fiscal Year: 2005..Since activated HSC play a key role in hepatic fibrogenesis, these experiments will contribute to an improved understanding of the basic biochemical processes underlying hepatic fibrosis. ..
- Are Volume Standards Accurate Measures of Quality?Laurent Glance; Fiscal Year: 2005..abstract_text> ..
- Mechanisms of Steroid Resistance in Severe AsthmaWilliam Calhoun; Fiscal Year: 2005..abstract_text> ..
- Addressing Light Smoking in African AmericansKolawole Okuyemi; Fiscal Year: 2006..The research may provide crucial information to advance our understanding of smoking and set the stage for further research in this understudied population of AA cigarette smokers. ..
- Natural History of POP-- A Prospective Cohort StudyIngrid Nygaard; Fiscal Year: 2005..The national cost burden is large. This project will provide fundamental data to guide future decisions about intervention threshold, preventative measures, and risk factor modification. ..
- Methylphenidate for Fatigue in Advanced Cancer PatientsEduardo Bruera; Fiscal Year: 2009....
- Defibrotide for the treatment of severe hepatic veno-cc*Paul Richardson; Fiscal Year: 2007..Abstract Not Provided ..
- COLUMBIA-ADARC-CORNELL AIDS CLINICAL TRIALS UNITScott Hammer; Fiscal Year: 2006..Thus, the Columbia-ADARC ACTU will be an active participant in the Group's mission to improve the health of HIV infected individuals and set standards for treatment of HIV disease. ..
- HOMOCYSTEINE, INFLAMMATION, AND ATHEROGENESISMichael Rosenfeld; Fiscal Year: 2001..Under Aim 2, the investigator will determine the mechanism by which HC and lipid accumulation alter glutathione and NADH/NADPH metabolism, thereby activating macrophages in vitro. ..
- Varian 4 Tesla MRI/MRS for Neuro-degenerative DiseasesMichael Weiner; Fiscal Year: 2002..These expected results emphasize the practical outcome and significance of this research. ..
- AROUSAL AND ANXIETY IN DYSFUNCTIONAL MEN AND WOMENDavid Barlow; Fiscal Year: 2001..The purpose of this series of studies is to explore more precisely the role of cognitive and attentional processes specified in our model of sexual dysfunction. ..
- Glucose Regulation of Pancreatic Islet Gene ExperessionRODERICK PAUL ROBERTSON; Fiscal Year: 2010..We will study whether increasing antioxidant protection protects these cells and prevents deterioration of glucose control in diabetes. ..
- The Genetic Basis of Human Tooth AgenesisSylvia Frazier Bowers; Fiscal Year: 2006..This research is central to the career goals of the applicant, which are to perform independent and original research that is relevant to identifying genetic factors that lead to orthodontic problems. ..
- Regulation of Bladder Smooth Muscle HyperplasiaPaul Austin; Fiscal Year: 2007..Work of this nature may decrease the morbidity and mortality that is caused by bladder outlet obstruction. ..
- Improving Varenicline Adherence and Outcome in Homeless SmokersKolawole S Okuyemi; Fiscal Year: 2010....
- Hypoxia as a target for the treatment of brain tumorsErwin Van Meir; Fiscal Year: 2003..The translation of these preclinical studies have the potential to directly benefit human health by improving the survival of children and adults with cancer. ..
- Basic Science of Tendon To Bone HealingAsheesh Bedi; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- THERAPEUTIC MODULATION OF ANGIOGENESIS IN HUMAN GLIOMASErwin G Van Meir; Fiscal Year: 2011..Improving the treatment of malignant gliomas, an incurable disease, is an important human health goal. ..
- Treatment of Early Age Mania (TEAM)Graham Emslie; Fiscal Year: 2003..D. (4) University of Texas, Dallas, PI: Graham Emslie, M.D. (5) University of Texas, Galveston, PI: Karen Dineen Wagner, M.D. and (6) Washington University, St. Louis, PI; Joan Luby, M.D. ..
- THE ROLE OF MYCOBACTERIA IN CROHN'S DISEASEDavid Graham; Fiscal Year: 2005..The results of this study should either confirm or refute the proposed etiologic association of M. paratuberculosis and Crohn's disease as well as the identification of patients with Crohn's disease and M. paratuberculosis. ..
- Flavopiridol as a Potential Therapy in Multiple MyelomaKeith Bible; Fiscal Year: 2005..Results of proposed studies will improve understanding of the effects and mechanism(s) of action of flavopiridol in myeloma cells, thereby potentially contributing to the further clinical development of the drug. ..
- Effects of Menthol on Bupropion PharmacokineticsKolawole Okuyemi; Fiscal Year: 2006..abstract_text> ..
- Flavopiridol Targets Transcription Factor/DNA ComplexesKeith Bible; Fiscal Year: 2006..unreadable] [unreadable]..
- ACISR - Early-Onset Mood & Anxiety DisorderDavid Brent; Fiscal Year: 2006..The Center will enhance the development of the next generation of intervention and services researchers and will disseminate new research information to families, practitioners, and researchers. ..
- Oxidative Stress and Genetics of PrehypertensionShawna Nesbitt; Fiscal Year: 2004..abstract_text> ..
- TREATMENT OF PANIC DISORDER--LONG TERM STRATEGIESDavid Barlow; Fiscal Year: 2003..These sites already have in place the trained and certified assessment and treatment personnel and rigorous monitoring procedures that are essential for the conduct of a study such as the one we propose. ..
- A Unified Treatment for Anxiety DisordersDavid Barlow; Fiscal Year: 2008..If successful, this will be the first step towards a large scale treatment study validating a unified psychosocial approach to the emotional disorders. ..
- Novel Therapies for High-Risk NeuroblastomaJulie Park; Fiscal Year: 2006..abstract_text> ..
- A hypoxia-dependent adenovirus for glioma therapyErwin Van Meir; Fiscal Year: 2005..The translation of these preclinical studies have the potential to directly benefit human health by improving the survival of cancer patients. ..
- Hyperglycemia, Frailty and Disability in Older WomenCaroline Blaum; Fiscal Year: 2006..abstract_text> ..
- Phase II Study of 44Gy from 131I-81C6 for CNS TumorsDavid Reardon; Fiscal Year: 2004..To further define the toxicity of this approach and Specific Aim 3.To determine the impact of this therapy on quality of life. ..
- Immunologic Control of Drug-resistant HIV-1Steven Deeks; Fiscal Year: 2005..Finally, since we will estimate the relative in vivo thresholds for HIV-mediated immunogenicity and pathogenicity, these studies may also have implications for vaccine development. ..
- Structure Function Analysis of TB PyrazinamidaseYing Zhang; Fiscal Year: 2005..These studies will provide important information about mechanisms of PZA action and resistance and may help design new antituberculosis drugs. ..
- Treatment Intensification for Drug-Resistant HIVSteven Deeks; Fiscal Year: 2004..Funding for the pilot clinical trial has been obtained from other sources; funding is requested in this proposal only for costs associated with the measurements of immunologic response to drug-resistant HIV-1. ..
- TREATMENT OF SSRI-RESISTANT DEPRESSION IN ADOLESCENTSDavid Brent; Fiscal Year: 2006..This site is based in Pittsburgh, which also serves as the Data Coordinating Center for the study [unreadable] [unreadable]..