treatment failure

Summary

Summary: A measure of the quality of health care by assessment of unsuccessful results of management and procedures used in combating disease, in individual cases or series.

Top Publications

  1. ncbi Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study
    Andri Rauch
    University Clinic of Infectious Diseases, University Hospital Bern and University of Bern, Bern, Switzerland
    Gastroenterology 138:1338-45, 1345.e1-7. 2010
  2. ncbi Second-line treatment in the Malawi antiretroviral programme: high early mortality, but good outcomes in survivors, despite extensive drug resistance at baseline
    M C Hosseinipour
    University of North Carolina Project, Lilongwe, Malawi
    HIV Med 11:510-8. 2010
  3. pmc Low-frequency HIV-1 drug resistance mutations and risk of NNRTI-based antiretroviral treatment failure: a systematic review and pooled analysis
    Jonathan Z Li
    Section of Retroviral Therapeutics, Brigham and Women s Hospital, Harvard Medical School, Harvard University, Boston, Massachusetts 02139, USA
    JAMA 305:1327-35. 2011
  4. ncbi Unnecessary antiretroviral treatment switches and accumulation of HIV resistance mutations; two arguments for viral load monitoring in Africa
    Kim C E Sigaloff
    PharmAccess Foundation, Amsterdam, The Netherlands
    J Acquir Immune Defic Syndr 58:23-31. 2011
  5. pmc High-level cefixime- and ceftriaxone-resistant Neisseria gonorrhoeae in France: novel penA mosaic allele in a successful international clone causes treatment failure
    Magnus Unemo
    WHO Collaborating Centre for Gonorrhoea and Other STIs, Department of Laboratory Medicine, Microbiology, Orebro University Hospital, Orebro, Sweden
    Antimicrob Agents Chemother 56:1273-80. 2012
  6. ncbi Predictors of virologic failure and resistance in HIV-infected patients treated with nevirapine- or efavirenz-based antiretroviral therapy
    Jean Jacques Parienti
    Department of Infectious Diseases and Virology, Côte de Nacre Hospital, Caen, France
    Clin Infect Dis 38:1311-6. 2004
  7. ncbi Neisseria gonorrhoeae treatment failure and susceptibility to cefixime in Toronto, Canada
    Vanessa G Allen
    Public Health Ontario Laboratories, 81 Resources Rd, Toronto, ON M9P 3T1, Canada
    JAMA 309:163-70. 2013
  8. ncbi Phenotypic and genetic characterization of the first two cases of extended-spectrum-cephalosporin-resistant Neisseria gonorrhoeae infection in South Africa and association with cefixime treatment failure
    David A Lewis
    Centre for HIV and Sexually Transmitted Infections, National Institute for Communicable Diseases, National Health Laboratory Service, 1 Modderfontein Road, Sandringham 2192, South Africa
    J Antimicrob Chemother 68:1267-70. 2013
  9. pmc Safety and efficacy of simplified antibiotic regimens for outpatient treatment of serious infection in neonates and young infants 0-59 days of age in Bangladesh: design of a randomized controlled trial
    Abdullah H Baqui
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Pediatr Infect Dis J 32:S12-8. 2013
  10. ncbi Accumulation of drug resistance and loss of therapeutic options precede commonly used criteria for treatment failure in HIV-1 subtype-C-infected patients
    Roos E Barth
    Department of Internal Medicine and Infectious Diseases, University Medical Centre Utrecht, Utrecht, The Netherlands
    Antivir Ther 17:377-86. 2012

Research Grants

  1. A Community Collaboration to Increase HIV Serostatus Awareness for At Risk AA MSM
    Melanie Thompson; Fiscal Year: 2008
  2. Treatment with Exercise Augmentation for Depression
    Madhukar Trivedi; Fiscal Year: 2006
  3. CARE Network-UCSD Clinical Center
    Robert Zeiger; Fiscal Year: 2008
  4. REVAMP Follow-Up
    Madhukar Trivedi; Fiscal Year: 2008
  5. ESTIMATING EFFICACY OF A MEDICAL INTERVENTION
    James Trussell; Fiscal Year: 2001
  6. Inflammation and Insulin Resistance in PAD
    Mark Creager; Fiscal Year: 2007
  7. 2007 Atherosclerosis Gordon Research Conference
    Michael Rosenfeld; Fiscal Year: 2007
  8. Diesel Exhaust and Atherosclerotic Plaque Stability
    Michael Rosenfeld; Fiscal Year: 2007
  9. Real-time Minimal Residual Disease assay of Pediatric B-Cell Non-Hodgkin Lymphoma
    Bruce Shiramizu; Fiscal Year: 2007
  10. SPAN-Xb as an immunologic target for CML
    SEAH LIM; Fiscal Year: 2007

Detail Information

Publications287 found, 100 shown here

  1. ncbi Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study
    Andri Rauch
    University Clinic of Infectious Diseases, University Hospital Bern and University of Bern, Bern, Switzerland
    Gastroenterology 138:1338-45, 1345.e1-7. 2010
    ..We performed a genome-wide association study to screen for host genetic determinants of HCV persistence and response to therapy...
  2. ncbi Second-line treatment in the Malawi antiretroviral programme: high early mortality, but good outcomes in survivors, despite extensive drug resistance at baseline
    M C Hosseinipour
    University of North Carolina Project, Lilongwe, Malawi
    HIV Med 11:510-8. 2010
    ..Advanced disease progression may occur before switching to second-line ART. We report outcomes for patients evaluated and initiated on second-line treatment in Malawi...
  3. pmc Low-frequency HIV-1 drug resistance mutations and risk of NNRTI-based antiretroviral treatment failure: a systematic review and pooled analysis
    Jonathan Z Li
    Section of Retroviral Therapeutics, Brigham and Women s Hospital, Harvard Medical School, Harvard University, Boston, Massachusetts 02139, USA
    JAMA 305:1327-35. 2011
    ....
  4. ncbi Unnecessary antiretroviral treatment switches and accumulation of HIV resistance mutations; two arguments for viral load monitoring in Africa
    Kim C E Sigaloff
    PharmAccess Foundation, Amsterdam, The Netherlands
    J Acquir Immune Defic Syndr 58:23-31. 2011
    ..Frequencies of unnecessary switches, patterns of HIV drug resistance, and risk factors for the accumulation of nucleoside reverse transcriptase inhibitor (NRTI)-associated mutations were evaluated...
  5. pmc High-level cefixime- and ceftriaxone-resistant Neisseria gonorrhoeae in France: novel penA mosaic allele in a successful international clone causes treatment failure
    Magnus Unemo
    WHO Collaborating Centre for Gonorrhoea and Other STIs, Department of Laboratory Medicine, Microbiology, Orebro University Hospital, Orebro, Sweden
    Antimicrob Agents Chemother 56:1273-80. 2012
    ..with high-level cefixime and ceftriaxone resistance which was isolated in France and most likely caused a treatment failure with cefixime...
  6. ncbi Predictors of virologic failure and resistance in HIV-infected patients treated with nevirapine- or efavirenz-based antiretroviral therapy
    Jean Jacques Parienti
    Department of Infectious Diseases and Virology, Côte de Nacre Hospital, Caen, France
    Clin Infect Dis 38:1311-6. 2004
    ..8-180.3; P<.0001). Patients' previous adherence to therapy and drugs genetic barriers, not only the number of pills or doses involved, should be taken into consideration in the decision to simplify highly active antiretroviral therapy...
  7. ncbi Neisseria gonorrhoeae treatment failure and susceptibility to cefixime in Toronto, Canada
    Vanessa G Allen
    Public Health Ontario Laboratories, 81 Resources Rd, Toronto, ON M9P 3T1, Canada
    JAMA 309:163-70. 2013
    ..Increased minimum inhibitory concentrations (MICs) to cefixime have been identified worldwide and have been associated with reports of clinical failure...
  8. ncbi Phenotypic and genetic characterization of the first two cases of extended-spectrum-cephalosporin-resistant Neisseria gonorrhoeae infection in South Africa and association with cefixime treatment failure
    David A Lewis
    Centre for HIV and Sexually Transmitted Infections, National Institute for Communicable Diseases, National Health Laboratory Service, 1 Modderfontein Road, Sandringham 2192, South Africa
    J Antimicrob Chemother 68:1267-70. 2013
    To describe the phenotypic and genetic characteristics of the first two cases of extended-spectrum cephalosporin (ESC)-resistant Neisseria gonorrhoeae in South Africa, one of which was associated with verified cefixime treatment failure.
  9. pmc Safety and efficacy of simplified antibiotic regimens for outpatient treatment of serious infection in neonates and young infants 0-59 days of age in Bangladesh: design of a randomized controlled trial
    Abdullah H Baqui
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Pediatr Infect Dis J 32:S12-8. 2013
    ..Because access to care is limited in settings with high mortality, exclusive reliance on the current recommendation of 7-10 days of parenteral antibiotic treatment is a barrier to provision of adequate treatment of newborn infections...
  10. ncbi Accumulation of drug resistance and loss of therapeutic options precede commonly used criteria for treatment failure in HIV-1 subtype-C-infected patients
    Roos E Barth
    Department of Internal Medicine and Infectious Diseases, University Medical Centre Utrecht, Utrecht, The Netherlands
    Antivir Ther 17:377-86. 2012
    ..Here, accumulation of resistance and consequences for second-line therapy were investigated in African HIV-1 subtype-C-infected patients...
  11. pmc Risk factors for tuberculosis treatment failure, default, or relapse and outcomes of retreatment in Morocco
    Kelly E Dooley
    Johns Hopkins University School of Medicine, Baltimore, USA
    BMC Public Health 11:140. 2011
    ..In this study, we evaluated the risk factors for initial treatment failure, default, or early relapse leading to the need for tuberculosis retreatment in Morocco...
  12. pmc The public health approach to identify antiretroviral therapy failure: high-level nucleoside reverse transcriptase inhibitor resistance among Malawians failing first-line antiretroviral therapy
    Mina C Hosseinipour
    University of North Carolina Project, Lilongwe, Malawi
    AIDS 23:1127-34. 2009
    ..We evaluated drug resistance patterns among patients failing first-line ART on the basis of clinical or immunological criteria in Lilongwe and Blantyre, Malawi...
  13. ncbi Efavirenz plasma levels can predict treatment failure and central nervous system side effects in HIV-1-infected patients
    C Marzolini
    Department of Medicine, University Hospital of Lausanne, Switzerland
    AIDS 15:71-5. 2001
    ..The aim of this study was to determine whether efavirenz plasma concentration monitoring could predict treatment failure and central nervous system (CNS) tolerability...
  14. pmc Pre-existing minority drug-resistant HIV-1 variants, adherence, and risk of antiretroviral treatment failure
    Roger Paredes
    Brigham and Women s Hospital, Harvard Medical School, Cambridge, MA 02139, USA
    J Infect Dis 201:662-71. 2010
    ..The clinical relevance of detecting minority drug-resistant human immunodeficiency virus type 1 (HIV-1) variants is uncertain...
  15. ncbi Treatment failure and resistance with direct-acting antiviral drugs against hepatitis C virus
    Jean Michel Pawlotsky
    Department of Virology, Hopital Henri Mondor, Université Paris Est Créteil, France
    Hepatology 53:1742-51. 2011
    ..This article reviews patterns of resistance to HCV DAA drugs in development, the mechanisms underlying treatment failure when these drugs are combined with pegylated interferon-α and ribavirin, the consequences of treatment ..
  16. ncbi Antiretroviral treatment of adult HIV infection: 2010 recommendations of the International AIDS Society-USA panel
    Melanie A Thompson
    AIDS Research Consortium of Atlanta, Atlanta, Georgia, USA
    JAMA 304:321-33. 2010
    ....
  17. ncbi Treatment of nasopharyngeal carcinoma with intensity-modulated radiotherapy: the Hong Kong experience
    Michael K M Kam
    Clinical Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    Int J Radiat Oncol Biol Phys 60:1440-50. 2004
    ..To evaluate the efficacy of using intensity-modulated radiotherapy (IMRT) in the primary treatment of nasopharyngeal carcinoma (NPC), including the role of dose escalation above 66 Gy level...
  18. pmc Viremia and drug resistance among HIV-1 patients on antiretroviral treatment: a cross-sectional study in Soweto, South Africa
    Ziad El-Khatib
    Division of Global Health IHCAR, Karolinska Institutet, Stockholm, Sweden
    AIDS 24:1679-87. 2010
    ..We assessed risk factors for viremia and drug resistance among long-term recipients of antiretroviral therapy (ART) in South Africa...
  19. pmc Simplified antibiotic regimens for the management of clinically diagnosed severe infections in newborns and young infants in first-level facilities in Karachi, Pakistan: study design for an outpatient randomized controlled equivalence trial
    Anita K M Zaidi
    Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan
    Pediatr Infect Dis J 32:S19-25. 2013
    ..Alternative, simpler antibiotic regimens that could be used in outpatient settings have the potential to save thousands of lives...
  20. ncbi Antidogmatic approaches to artemisinin resistance: reappraisal as treatment failure with artemisinin combination therapy
    Sanjeev Krishna
    Centre for Infection and Immunity, Division of Clinical Sciences, St George s, University of London, Cranmer Terrace, London SW17 0RE, UK
    Trends Parasitol 29:313-7. 2013
    ..criteria for defining artemisinin resistance that are not currently being applied and suggests the term 'treatment failure of artemisinin combination therapy' (TFACT) as a more accurate description of most cases of 'artemisinin ..
  21. pmc First report of Salmonella enterica serotype paratyphi A azithromycin resistance leading to treatment failure
    Aoife Molloy
    Department of Infectious Diseases, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Clin Microbiol 48:4655-7. 2010
    ..Resistance to fluoroquinolones is common and leads to more frequent use of newer agents like azithromycin. We report the first case of azithromycin resistance and treatment failure in a patient with S. Paratyphi A infection.
  22. ncbi Repopulation of cancer cells during therapy: an important cause of treatment failure
    John J Kim
    Department of Radiation Oncology, Princess Margaret Hospital and University of Toronto, 610 University Avenue, Toronto, ON M5G 2M9, Canada
    Nat Rev Cancer 5:516-25. 2005
    ..during the intervals between treatments and this process of repopulation is an important cause of treatment failure. Strategies developed to overcome repopulation have improved clinical outcomes, and now new strategies to ..
  23. ncbi Virological monitoring and resistance to first-line highly active antiretroviral therapy in adults infected with HIV-1 treated under WHO guidelines: a systematic review and meta-analysis
    Ravindra K Gupta
    UCL MRC Centre for Medical Molecular Virology, University College London Medical School, London, UK
    Lancet Infect Dis 9:409-17. 2009
    ..This Review highlights the need for cheap point-of-care viral-load tests to identify early viral failures and limit the emergence of resistance...
  24. ncbi Obesity is associated with worse peritoneal dialysis outcomes in the Australia and New Zealand patient populations
    Stephen P McDonald
    Australia and New Zealand Dialysis and Transplant Registry, Adelaide, Australia
    J Am Soc Nephrol 14:2894-901. 2003
    ..Such patients should be closely monitored during PD and should be considered for early transfer to an alternative renal replacement therapy if difficulties are experienced...
  25. pmc Switching to second-line antiretroviral therapy in resource-limited settings: comparison of programmes with and without viral load monitoring
    Olivia Keiser
    Institute of Social and Preventive Medicine ISPM, University of Bern, Bern, Switzerland
    AIDS 23:1867-74. 2009
    ..We examined switching from nonnucleoside reverse transcriptase inhibitor (NNRTI)-based first-line regimens to protease inhibitor-based regimens in Africa, South America and Asia...
  26. ncbi Deep V3 sequencing for HIV type 1 tropism in treatment-naive patients: a reanalysis of the MERIT trial of maraviroc
    Luke C Swenson
    BC Centre for Excellence in HIV AIDS, Vancouver, British Columbia, Canada
    Clin Infect Dis 53:732-42. 2011
    ..Results were compared with those obtained using the Enhanced Sensitivity Trofile Assay (ESTA), which is widely used in clinical practice...
  27. pmc TP53 disruptive mutations lead to head and neck cancer treatment failure through inhibition of radiation-induced senescence
    Heath D Skinner
    Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 18:290-300. 2012
    ..In this study, we use a classification of TP53 mutation (disruptive vs. nondisruptive) and examine impact on clinical outcomes and radiation sensitivity...
  28. ncbi Second-line rescue therapy with levofloxacin after H. pylori treatment failure: a Spanish multicenter study of 300 patients
    Javier P Gisbert
    Hospital de la Princesa, Madrid
    Am J Gastroenterol 103:71-6. 2008
    ..Our aim was to evaluate the efficacy and tolerability of a triple second-line levofloxacin-based regimen in patients with H. pylori eradication failure...
  29. ncbi Treatment failure in children in a randomized clinical trial with 10 and 20 days of meglumine antimonate for cutaneous leishmaniasis due to Leishmania viannia species
    R Palacios
    Centro Internacional de Entrenamiento e Investigaciones Medicas, Cali, Colombia
    Am J Trop Med Hyg 64:187-93. 2001
    ..Pathogenicity of infection and pharmacokinetics may affect the treatment response in children. New therapeutic alternatives should be evaluated in trials that include children and women...
  30. ncbi Misclassification of first-line antiretroviral treatment failure based on immunological monitoring of HIV infection in resource-limited settings
    Rami Kantor
    Division of Infectious Diseases, Brown University, Providence, Rhode Island, USA
    Clin Infect Dis 49:454-62. 2009
    ..The early identification of first-line antiretroviral treatment failure is critical to prevent morbidity, mortality, and drug resistance...
  31. ncbi Serum albumin level predicts initial intravenous immunoglobulin treatment failure in Kawasaki disease
    Ho Chang Kuo
    Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center, Taiwan
    Acta Paediatr 99:1578-83. 2010
    ..However, many patients with KD still show poor response to initial IVIG treatment. This study was conducted to investigate the risk factors for initial IVIG treatment failure in KD.
  32. pmc IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: results from a 24-week multicentre randomised placebo-controlled trial
    P Emery
    Leeds Teaching Hospitals Trust, University of Leeds, Leeds, UK
    Ann Rheum Dis 67:1516-23. 2008
    ..The phase III RADIATE study examined the efficacy and safety of tocilizumab, an anti-IL-6 receptor monoclonal antibody in patients with rheumatoid arthritis (RA) refractory to tumour necrosis factor (TNF) antagonist therapy...
  33. ncbi The COMS randomized trial of iodine 125 brachytherapy for choroidal melanoma: IV. Local treatment failure and enucleation in the first 5 years after brachytherapy. COMS report no. 19
    Lee M Jampol
    Department of Ophthalmology, Northwestern University Medical School, Chicago, Illinois, USA
    Ophthalmology 109:2197-206. 2002
    To describe the frequency and predictors of local treatment failure and enucleation after iodine 125 (I(125)) brachytherapy in patients with choroidal melanoma treated and followed up in a large randomized clinical trial.
  34. ncbi The relationship of eosinophilia to intravenous immunoglobulin treatment failure in Kawasaki disease
    Ho Chang Kuo
    Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center, Kaohsiung, Taiwan
    Pediatr Allergy Immunol 18:354-9. 2007
    ..of eosinophils in Kawasaki disease (KD) and the relationship to initial intravenous immunoglobulin (IVIG) treatment failure. A retrospective analysis of all children who were admitted and met the criteria of KD between 1999 and 2005...
  35. ncbi Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group
    R A DeFronzo
    Diabetes Division, University of Texas Health Science Center, San Antonio, TX 78284, USA
    N Engl J Med 333:541-9. 1995
    ..Sulfonylurea drugs have been the only oral therapy available for patients with non-insulin-dependent diabetes mellitus (NIDDM) in the United States. Recently, however, metformin has been approved for the treatment of NIDDM...
  36. ncbi Pathological results and rates of treatment failure in high-risk prostate cancer patients after radical prostatectomy
    Jochen Walz
    Cancer Prognostics and Health Outcomes Unit, University of Montreal, Montreal, Canada
    BJU Int 107:765-70. 2011
    ..To investigate the pathological characteristics and the rates of biochemical recurrence (BCR) -free survival after radical prostatectomy (RP) in men with high-risk prostate cancer...
  37. ncbi Conservation of first-line antiretroviral treatment regimen where therapeutic options are limited
    Catherine Orrell
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, South Africa
    Antivir Ther 12:83-8. 2007
    ....
  38. pmc Lopinavir/ritonavir monotherapy after virologic failure of first-line antiretroviral therapy in resource-limited settings
    John A Bartlett
    Duke University Medical Center, Durham, NC 27710, USA
    AIDS 26:1345-54. 2012
    ..To evaluate virologic response rates of lopinavir/ritonavir (LPV/r) monotherapy as second-line antiretroviral treatment (ART) among adults in resource-limited settings (RLSs)...
  39. pmc Iron status predicts treatment failure and mortality in tuberculosis patients: a prospective cohort study from Dar es Salaam, Tanzania
    Sheila Isanaka
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS ONE 7:e37350. 2012
    ..The aim of the present analysis was to examine the association of iron status with the risk of TB progression and death...
  40. pmc Natural killer inhibitory receptor expression associated with treatment failure and interleukin-28B genotype in patients with chronic hepatitis C
    Lucy Golden-Mason
    Division of Gastroenterology and Hepatology, Hepatitis C Center, Department of Medicine, University of Colorado Denver and National Jewish Hospital, Denver, CO, USA
    Hepatology 54:1559-69. 2011
    ....
  41. ncbi Limited impact of IL28B genotype on response rates in telaprevir-treated patients with prior treatment failure
    Stanislas Pol
    Universite Paris Descartes, INSERM Unité 1016, and Assistance Publique Hopitaux de Paris, Cochin Hospital, Paris, France
    J Hepatol 58:883-9. 2013
    ..This subanalysis of the REALIZE study evaluated the impact of IL28B polymorphisms on sustained virologic response (SVR) in telaprevir-treated, HCV genotype 1-infected patients with prior PegIFN/RBV treatment failure.
  42. pmc Failure of immunologic criteria to appropriately identify antiretroviral treatment failure in Uganda
    Steven J Reynolds
    National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA
    AIDS 23:697-700. 2009
    ..Our objective was to evaluate immunologic failure criteria against gold standard virologic monitoring...
  43. ncbi Emergence of drug resistance in HIV type 1-infected patients after receipt of first-line highly active antiretroviral therapy: a systematic review of clinical trials
    Ravindra Gupta
    Division of Infection and Immunity, University College London, London, United Kingdom
    Clin Infect Dis 47:712-22. 2008
    ..Resistance to antiretroviral combination therapy is associated with increased mortality. Understanding the relative risks of emerging resistance to first-line therapy is of importance for both resource-rich and resource-poor settings...
  44. ncbi Outcome of high-risk myelodysplastic syndrome after azacitidine treatment failure
    Thomas Prebet
    Sidney Kimmel Cancer Center, Johns Hopkins University, Baltimore, MD, USA
    J Clin Oncol 29:3322-7. 2011
    ..ie, International Prognostic Scoring System high or intermediate 2) myelodysplastic syndrome (MDS), but most patients will experience primary or secondary treatment failure. The outcome of these patients has not yet been described.
  45. pmc Long-term consequences of the delay between virologic failure of highly active antiretroviral therapy and regimen modification
    Maya L Petersen
    Division of Biostatistics, Berkeley School of Public Health, Berkeley, California 94720, USA
    AIDS 22:2097-106. 2008
    ..These recommendations have not been tested in observational studies or large randomized trials. We evaluated the consequences of delayed modification following virologic failure...
  46. ncbi Intracellular persistence of Staphylococcus aureus small-colony variants within keratinocytes: a cause for antibiotic treatment failure in a patient with darier's disease
    C von Eiff
    Institute of Medical Microbiology, Westfalische Wilhelms Universitat Munster, Munster, Germany
    Clin Infect Dis 32:1643-7. 2001
    ..The presence of intracellular S. aureus SCVs may protect against host defenses and antibiotic therapy and thus may have contributed to this patient's very prolonged skin infection...
  47. ncbi Treatment failure and mortality factors in patients receiving second-line HIV therapy in resource-limited countries
    Mar Pujades-Rodriguez
    Epicentre, Médecins Sans Frontières 42 bis, Bd, 8 rue Saint Sabin, 75011 Paris, France
    JAMA 304:303-12. 2010
    ..Limited access to further therapeutic options makes essential the evaluation of second-line regimen efficacy in these settings...
  48. ncbi Randomized phase II study of docetaxel and prednisone with or without OGX-011 in patients with metastatic castration-resistant prostate cancer
    Kim N Chi
    British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    J Clin Oncol 28:4247-54. 2010
    ..To determine the clinical activity of OGX-011, an antisense inhibitor of clusterin, in combination with docetaxel/prednisone in patients with metastatic castration-resistant prostate cancer...
  49. ncbi Mucosal leishmaniasis: description of case management approaches and analysis of risk factors for treatment failure in a cohort of 140 patients in Brazil
    V S Amato
    Infectious and Parasitic Diseases Clinic, Hospital das Clinicas, Medical School, University of Sao Paulo, Sao Paulo, Brazil
    J Eur Acad Dermatol Venereol 23:1026-34. 2009
    ..Mucosal leishmaniasis is caused mainly by Leishmania braziliensis and it occurs months or years after cutaneous lesions. This progressive disease destroys cartilages and osseous structures from face, pharynx and larynx...
  50. pmc Antiretroviral therapies in women after single-dose nevirapine exposure
    Shahin Lockman
    Brigham and Women s Hospital, Boston, MA, USA
    N Engl J Med 363:1499-509. 2010
    ..Peripartum administration of single-dose nevirapine reduces mother-to-child transmission of human immunodeficiency virus type 1 (HIV-1) but selects for nevirapine-resistant virus...
  51. pmc Treatment failure resulting from resistance of Staphylococcus aureus to daptomycin
    Daniel J Skiest
    Baystate Medical Center, Division of Infectious Diseases, 759 Chestnut St, Springfield, MA 01199, USA
    J Clin Microbiol 44:655-6. 2006
    ..Clinicians should be aware of the possibility of daptomycin resistance and should consider routine testing for daptomycin susceptibility...
  52. ncbi FDG-PET after two cycles of chemotherapy predicts treatment failure and progression-free survival in Hodgkin lymphoma
    Martin Hutchings
    PET and Cyclotron Unit, Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital, 9, Blegdamsvej, DK 2100 Copenhagen Ø, Denmark
    Blood 107:52-9. 2006
    ..Early interim FDG-PET is a strong and independent predictor of PFS in HL. A positive early interim FDG-PET is highly predictive of progression in patients with advanced-stage or extranodal disease...
  53. ncbi Highest clinical effectiveness of rituximab in autoantibody-positive patients with rheumatoid arthritis and in those for whom no more than one previous TNF antagonist has failed: pooled data from 10 European registries
    Katerina Chatzidionysiou
    Department of Rheumatology, Karolinska University Hospital, Stockholm, Sweden
    Ann Rheum Dis 70:1575-80. 2011
    ..To assess the 6-month effectiveness of the first rituximab (RTX) course in rheumatoid arthritis (RA) and to identify possible predictors of response...
  54. pmc Outcomes after virologic failure of first-line ART in South Africa
    Richard A Murphy
    Operational Support Unit, Doctors Without Borders, New York, New York 10001, USA
    AIDS 24:1007-12. 2010
    ..To determine initial 24-week outcomes among prospectively enrolled patients with failure of initial antiretroviral therapy (ART)...
  55. ncbi Low-frequency K103N strengthens the impact of transmitted drug resistance on virologic responses to first-line efavirenz or nevirapine-based highly active antiretroviral therapy
    Anna Maria Geretti
    Department of Virology, Royal Free Hampstead NHS Trust, London, UK
    J Acquir Immune Defic Syndr 52:569-73. 2009
    ..There are conflicting data on the impact of low-frequency transmitted drug-resistant mutants on responses to first-line highly active antiretroviral therapy (HAART)...
  56. ncbi Diagnosis of antiretroviral therapy failure in Malawi: poor performance of clinical and immunological WHO criteria
    Joep J G van Oosterhout
    Department of Medicine, University of Malawi College of Medicine, Blantyre, Malawi
    Trop Med Int Health 14:856-61. 2009
    ..We wanted to study the impact of only using clinical and immunological monitoring on the diagnosis of virological ART failure under routine circumstances...
  57. ncbi Low level of the K103N HIV-1 above a threshold is associated with virological failure in treatment-naive individuals undergoing efavirenz-containing therapy
    Derrick D Goodman
    Gilead Sciences Inc, Durham, North Carolina, USA
    AIDS 25:325-33. 2011
    ..Here, we analyzed whether the presence of low levels of K103N at baseline correlated with virologic failure...
  58. pmc Which subgroup of patients with rheumatoid arthritis benefits from switching to rituximab versus alternative anti-tumour necrosis factor (TNF) agents after previous failure of an anti-TNF agent?
    A Finckh
    University Hospital of Geneva, Switzerland
    Ann Rheum Dis 69:387-93. 2010
    ..It remains unclear in which clinical settings these therapeutic strategies offer most benefit...
  59. ncbi Mycobacterium tuberculosis Beijing genotype is an independent risk factor for tuberculosis treatment failure in Indonesia
    Ida Parwati
    Department of Clinical Pathology, Hasan Sadikin Hospital, Medical Faculty, Universitas Padjadjaran, Bandung, Indonesia
    J Infect Dis 201:553-7. 2010
    ..We examined whether Beijing strains increase treatment failure in a prospective cohort study in Indonesia...
  60. pmc Mortality after failure of antiretroviral therapy in sub-Saharan Africa
    Olivia Keiser
    Institute of Social and Preventive Medicine ISPM, University of Bern, Bern, Switzerland
    Trop Med Int Health 15:251-8. 2010
    To assess the outcome of patients who experienced treatment failure with antiretrovirals in sub-Saharan Africa.
  61. ncbi Risk factors associated with default, failure and death among tuberculosis patients treated in a DOTS programme in Tiruvallur District, South India, 2000
    T Santha
    Tuberculosis Research Centre, Chetput, Chennai, India
    Int J Tuberc Lung Dis 6:780-8. 2002
    ..To identify risk factors associated with default, failure and death among tuberculosis patients treated in a newly implemented DOTS programme in South India...
  62. ncbi Ambulatory short-course high-dose oral amoxicillin for treatment of severe pneumonia in children: a randomised equivalency trial
    Tabish Hazir
    Children s Hospital, Pakistan Institute of Medical Sciences, Islamabad, Pakistan
    Lancet 371:49-56. 2008
    ..Our aim was to determine whether home treatment with high-dose oral amoxicillin and inpatient treatment with parenteral ampicillin were equivalent for the treatment of severe pneumonia in children...
  63. ncbi Resistance to antimony and treatment failure in human Leishmania (Viannia) infection
    Ricardo Rojas
    Centro Internacional de Entrenamiento e Investigaciones Medicas, Cali, Colombia, and Centre Hospitalier Universitaire Laval, Quebec, Canada
    J Infect Dis 193:1375-83. 2006
    ..The role of drug resistance in treatment failure has been difficult to ascertain because therapeutic response is multifactorial, and the efficacy of ..
  64. pmc A review of the virological efficacy of the 4 World Health Organization-recommended tenofovir-containing regimens for initial HIV therapy
    Michele W Tang
    Department of Medicine, Division of Infectious Diseases, Stanford University, California 94305 5107, USA
    Clin Infect Dis 54:862-75. 2012
    ..Further study of TDF/3TC/NVP is required before it is widely deployed for initial ARV therapy...
  65. pmc Virologic failure of protease inhibitor-based second-line antiretroviral therapy without resistance in a large HIV treatment program in South Africa
    Julie H Levison
    Division of General Medicine Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 7:e32144. 2012
    ..We investigated the prevalence of wild-type virus (no major drug resistance) and drug resistance mutations at second-line antiretroviral treatment (ART) failure in a large HIV treatment program in South Africa...
  66. ncbi The cost-effectiveness of spinal cord stimulation in the treatment of failed back surgery syndrome
    Rod S Taylor
    Peninsula Medical School, Universities of Exeter and Plymouth, UK
    Clin J Pain 26:463-9. 2010
    ..We present previously unavailable details of the National Institute of Health and Clinical Excellence analysis and an analysis of the impact on SCS cost effectiveness of rechargeable implanted pulse generators (IPGs)...
  67. pmc Treatment failure among Kenyan children with severe pneumonia--a cohort study
    Clare Webb
    Kenya Medical Research Institute KEMRI, Centre for Geographic Medicine Research, Kilifi, Kenya
    Pediatr Infect Dis J 31:e152-7. 2012
    Pneumonia is the leading cause of childhood mortality worldwide. The World Health Organization recommends presumptive treatment based on clinical syndromes. Recent studies raise concerns over the frequency of treatment failure in Africa.
  68. ncbi Association of corticosteroid dose and route of administration with risk of treatment failure in acute exacerbation of chronic obstructive pulmonary disease
    Peter K Lindenauer
    Center for Quality of Care Research, Baystate Medical Center, 759 Chestnut St, Springfield, MA 01199, USA
    JAMA 303:2359-67. 2010
    ..Systemic corticosteroids are beneficial for patients hospitalized with acute exacerbation of chronic obstructive pulmonary disease (COPD); however, their optimal dose and route of administration are uncertain...
  69. ncbi Association between smoking status, other factors and tuberculosis treatment failure in Morocco
    N Tachfouti
    Laboratory of Epidemiology, Clinical Research and Community Health, Faculty of Medicine, Fez, Morocco
    Int J Tuberc Lung Dis 15:838-43. 2011
    The association between smoking and tuberculosis (TB) treatment failure has not yet been assessed in Morocco.
  70. ncbi The phenomenon of treatment failures in Human African Trypanosomiasis
    R Brun
    Swiss Tropical Institute, Basel, Switzerland
    Trop Med Int Health 6:906-14. 2001
    ..In conclusion, a combination of factors rather than a single one may be responsible for the phenomenon of melarsoprol treatment failures in T. b. gambiense patients...
  71. pmc The clinical and economic impact of genotype testing at first-line antiretroviral therapy failure for HIV-infected patients in South Africa
    Julie H Levison
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA
    Clin Infect Dis 56:587-97. 2013
    ..After adherence counseling, these patients may safely and effectively continue first-line ART, thereby delaying more expensive second-line ART...
  72. ncbi Dentinal tubule infection as the cause of recurrent disease and late endodontic treatment failure: a case report
    Adalberto R Vieira
    Brazilian Association of Dentistry, Juiz de Fora, Minas Gerais, Brazil
    J Endod 38:250-4. 2012
    ..This article describes a case of recurrent post-treatment apical periodontitis and late failure after endodontic retreatment performed in a single visit...
  73. pmc Early surgical ligation versus a conservative approach for management of patent ductus arteriosus that fails to close after indomethacin treatment
    Nami Jhaveri
    Department of Pediatrics, University of California, San Francisco, CA 94143 0544, USA
    J Pediatr 157:381-7, 387.e1. 2010
    ..To examine whether a more conservative approach to treating patent ductus arteriosus (PDA) is associated with an increase or decrease in morbidity compared with an approach involving early PDA ligation...
  74. ncbi Treatment outcomes of patients on second-line antiretroviral therapy in resource-limited settings: a systematic review and meta-analysis
    Olawale Ajose
    Clinton Health Access Initiative, Dar es Salaam, Tanzania
    AIDS 26:929-38. 2012
    ..We carried out a systematic review in order to summarize reported rates and reasons for virological failure among people on second-line therapy in resource-limited settings...
  75. pmc Comparative genome sequencing of an isogenic pair of USA800 clinical methicillin-resistant Staphylococcus aureus isolates obtained before and after daptomycin treatment failure
    Susan Boyle-Vavra
    Department of Pediatrics, University of Chicago, KCBD 4152, 900 E 57th Street, Chicago, IL 60657, USA
    Antimicrob Agents Chemother 55:2018-25. 2011
    We describe here a clinical daptomycin treatment failure in a patient with recurrent methicillin-resistant Staphylococcus aureus (MRSA) bacteremia in whom daptomycin was administered after a failed empirical treatment course with ..
  76. ncbi Monitoring of highly active antiretroviral therapy in HIV infection
    A Sarah Walker
    MRC Clinical Trials Unit, London, UK
    Curr Opin Infect Dis 24:27-33. 2011
    ..We review studies describing the outcomes and costs of different monitoring approaches, predominantly in low-income countries...
  77. pmc Maraviroc for previously treated patients with R5 HIV-1 infection
    Roy M Gulick
    Weill Cornell Medical College, New York, NY 10065, USA
    N Engl J Med 359:1429-41. 2008
    ..CC chemokine receptor 5 antagonists are a new class of antiretroviral agents...
  78. ncbi Meta-analysis: re-treatment of genotype I hepatitis C nonresponders and relapsers after failing interferon and ribavirin combination therapy
    A G Singal
    University of Michigan Medical Center, Ann Arbor, USA
    Aliment Pharmacol Ther 32:969-83. 2010
    ..The efficacy of re-treating genotype I hepatitis C virus (HCV) patients who failed combination therapy with interferon/pegylated interferon (PEG-IFN) and ribavirin remains unclear...
  79. ncbi The Mycobacterium tuberculosis Beijing genotype does not affect tuberculosis treatment failure in Vietnam
    Tran N Buu
    Pham Ngoc Thach Tuberculosis and Lung Disease Hospital, Ho Chi Minh City, Vietnam
    Clin Infect Dis 51:879-86. 2010
    ..that the Mycobacterium tuberculosis Beijing genotype causes more severe clinical disease and higher treatment failure rates with standard regimens, possibly in association with an increased risk of acquiring drug resistance...
  80. ncbi Mapping and characterization of vicriviroc resistance mutations from HIV-1 isolated from treatment-experienced subjects enrolled in a phase II study (VICTOR-E1)
    Paul M McNicholas
    Department of Infectious Diseases, Merck Research Labs, Kenilworth, NJ 07033, USA
    J Acquir Immune Defic Syndr 56:222-9. 2011
    ..Among the 79 VCV-treated subjects, 15 experienced virologic failure, and of these 5 had VCV-resistant virus. This study investigated the molecular basis for the changes in susceptibility to VCV in these subjects...
  81. pmc Absence of biallelic TCRgamma deletion predicts early treatment failure in pediatric T-cell acute lymphoblastic leukemia
    Alejandro Gutierrez
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Clin Oncol 28:3816-23. 2010
    ..To identify children with T-cell acute lymphoblastic leukemia (T-ALL) at high risk of induction chemotherapy failure by using DNA copy number analysis of leukemic cells collected at diagnosis...
  82. ncbi Aetiology of root canal treatment failure: why well-treated teeth can fail
    J F Siqueira
    Department of Endodontics, School of Dentistry, Estacio de Sa University, Rio de Janeiro, RJ, Brazil
    Int Endod J 34:1-10. 2001
    ..The purpose of this paper is to discuss the aetiology of the failure of root canal treatment, particularly in cases of well-treated root canals. Indications for the treatment of endodontic failures are also discussed...
  83. ncbi Associations with virologic treatment failure in adults on antiretroviral therapy in South Africa
    Mohammed Ishaaq Datay
    Department of Primary Health Care, University of Oxford, Oxford, UK
    J Acquir Immune Defic Syndr 54:489-95. 2010
    Highly active antiretroviral therapy (HAART) has been available in government facilities in the Western Cape Province of South Africa since 2001. We aimed to investigate factors associated with virologic treatment failure in this setting.
  84. ncbi Influence of multidrug resistance on tuberculosis treatment outcomes with standardized regimens
    Anton Mak
    Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute, McGill University, Montreal, Canada
    Am J Respir Crit Care Med 178:306-12. 2008
    ..Multidrug-resistant tuberculosis (TB) poses a major challenge to global TB control. We analyzed the association between estimated prevalence of initial or acquired MDR-TB, and treatment outcomes reported nationally...
  85. ncbi Early and late complications associated with transcatheter occlusion of secundum atrial septal defect
    Massimo Chessa
    Pediatric Cardiology, Istituto Policlinico San Donato, San Donato Milanese, Italy
    J Am Coll Cardiol 39:1061-5. 2002
    ..The goal of this study was to report the early and late complications experienced in atrial septal defect (ASD) transcatheter closure...
  86. pmc Early adherence to antiretroviral medication as a predictor of long-term HIV virological suppression: five-year follow up of an observational cohort
    Nathan Ford
    Medecins Sans Frontieres, Cape Town, South Africa
    PLoS ONE 5:e10460. 2010
    ..Previous studies have demonstrated a cross-sectional relationship between antiretroviral adherence and HIV virological suppression. We assessed the predictive value of baseline adherence in determining long-term virological failure...
  87. pmc Defining treatment failure in resource-rich settings
    Jeannette L Aldous
    University of California San Diego, Department of Medicine, Division of Infectious Diseases, Antiretroviral Research Center AVRC, San Diego, California 92103, USA
    Curr Opin HIV AIDS 4:459-66. 2009
    To define treatment failure in resource-rich settings; summarizing current guidelines, assays, the significance of detectable viremia, and definitions of treatment failure in clinical and research settings.
  88. ncbi Varied patterns of HIV-1 drug resistance on failing first-line antiretroviral therapy in South Africa
    Carole L Wallis
    Department of Molecular Medicine and Haematology, University of the Witwatersrand, Johannesburg, South Africa
    J Acquir Immune Defic Syndr 53:480-4. 2010
    ..HIV-1 drug resistance is a potential consequence of therapy. This study determined the pattern of HIV-1 drug resistance mutations after failure of first-line treatment regimens in South Africa...
  89. ncbi Limited value of CA 19-9 in predicting early treatment failure in patients with advanced pancreatic cancer
    Laurenz Vormittag
    Division of Clinical Oncology, Department of Medicine I and Cancer Center, Medical University Vienna, Vienna, Austria
    Oncology 77:140-6. 2009
    ..The role of CA 19-9 in monitoring treatment response in advanced pancreatic cancer remains uncertain. We assessed its value in predicting early failure of first-line chemotherapy...
  90. ncbi Clinical and parasite species risk factors for pentavalent antimonial treatment failure in cutaneous leishmaniasis in Peru
    Alejandro Llanos-Cuentas
    Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru
    Clin Infect Dis 46:223-31. 2008
    ..Knowledge of factors influencing treatment outcome is essential for successful management...
  91. ncbi Efficacy and safety of nevirapine extended-release once daily versus nevirapine immediate-release twice-daily in treatment-naive HIV-1-infected patients
    Joseph Gathe
    Therapeutic Concepts, Houston, Texas, USA
    Antivir Ther 16:759-69. 2011
    ..This study (VERxVE) compared the efficacy and safety of the new nevirapine extended-release (NVP XR) formulation dosed once daily with NVP immediate release (IR) twice daily in treatment-naive patients...
  92. ncbi Risk factors for treatment failure after melarsoprol for Trypanosoma brucei gambiense trypanosomiasis in Uganda
    D Legros
    Epicentre, Kampala, Uganda
    Trans R Soc Trop Med Hyg 93:439-42. 1999
    We evaluated the treatment failure rate among late-stage human African trypanosomiasis (HAT) patients treated with melarsoprol in Arua, northern Uganda, between September 1995 and August 1996, and identified the risk factors for ..
  93. ncbi Liver steatosis is an independent risk factor for treatment failure in patients with chronic hepatitis C
    Konstantinos C Thomopoulos
    Department of Internal Medicine, University Hospital, Patras, Greece
    Eur J Gastroenterol Hepatol 17:149-53. 2005
    ..The purpose of this study was to determine factors related to the presence of steatosis and to define the role of steatosis in the response to antiviral treatment in chronic hepatitis C patients...
  94. ncbi Cementless modular hip arthroplasty as a salvage operation for failed internal fixation of trochanteric fractures in elderly patients
    Jean Michel Laffosse
    Service de chirurgie orthopédique et de traumatologie, CHU Rangueil et CHU Purpan, Toulouse, France
    Acta Orthop Belg 73:729-36. 2007
    ..Primary arthroplasty with such an implant could be considered in selected cases such as markedly unstable fractures and in osteoporotic elderly patients...
  95. ncbi Baseline genotype as a predictor of virological failure to emtricitabine or stavudine in combination with didanosine and efavirenz
    Katyna Borroto-Esoda
    Gilead Sciences, Inc, 4611 University Drive, Durham, North Carolina 27707, USA
    AIDS Res Hum Retroviruses 23:988-95. 2007
    ....
  96. ncbi Ovarian cancer: strategies for overcoming resistance to chemotherapy
    Roshan Agarwal
    Section of Medicine, Institute for Cancer Research, Sutton, Surrey SM2 5NG, UK
    Nat Rev Cancer 3:502-16. 2003
    ..A better understanding of the mechanisms that underlie this drug resistance should allow treatment to be optimized, so that substantial improvements in the outlook for women with this disease can be achieved...
  97. ncbi Diagnosis and management of antiretroviral-therapy failure in resource-limited settings in sub-Saharan Africa: challenges and perspectives
    Anthony D Harries
    International Union Against Tuberculosis and Lung Disease, Paris, France
    Lancet Infect Dis 10:60-5. 2010
    ....
  98. ncbi Tumor necrosis factor (TNF) system levels in human immunodeficiency virus-infected patients during highly active antiretroviral therapy: persistent TNF activation is associated with virologic and immunologic treatment failure
    P Aukrust
    Section of Clinical Immunology, Research Institute of Nuclear Medicine, Oslo, Norway
    J Infect Dis 179:74-82. 1999
    ..Patients with virologic and immunologic treatment failure after 52 weeks had higher levels of several TNF components than other patients early after initiation of ..
  99. ncbi A single dose of erythropoietin in ST-elevation myocardial infarction
    Adriaan A Voors
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Eur Heart J 31:2593-600. 2010
    ..032). Conclusion A single high dose of EPO after a successful PCI for a STEMI did not improve LVEF after 6 weeks. However, the use of EPO was related to less major adverse cardiovascular events and a favourable clinical safety profile...
  100. pmc Frequency and evolution of Azole resistance in Aspergillus fumigatus associated with treatment failure
    Susan J Howard
    Regional Mycology Laboratory, Manchester, UK
    Emerg Infect Dis 15:1068-76. 2009
    ..Azole resistance in A. fumigatus is an emerging problem and may develop during azole therapy...

Research Grants89

  1. A Community Collaboration to Increase HIV Serostatus Awareness for At Risk AA MSM
    Melanie Thompson; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  2. Treatment with Exercise Augmentation for Depression
    Madhukar Trivedi; Fiscal Year: 2006
    ....
  3. CARE Network-UCSD Clinical Center
    Robert Zeiger; Fiscal Year: 2008
    ..abstract_text> ..
  4. REVAMP Follow-Up
    Madhukar Trivedi; Fiscal Year: 2008
    ....
  5. ESTIMATING EFFICACY OF A MEDICAL INTERVENTION
    James Trussell; Fiscal Year: 2001
    ....
  6. Inflammation and Insulin Resistance in PAD
    Mark Creager; Fiscal Year: 2007
    ..It is anticipated that the findings from this investigation will uncover novel pathophysiologic mechanisms and foster a new paradigm for the treatment of PAD. ..
  7. 2007 Atherosclerosis Gordon Research Conference
    Michael Rosenfeld; Fiscal Year: 2007
    ..The [unreadable] conference will provide a comprehensive overview of current research on [unreadable] atherosclerosis with a focus on the latest and most exciting developments in the field. [unreadable] [unreadable] [unreadable]..
  8. Diesel Exhaust and Atherosclerotic Plaque Stability
    Michael Rosenfeld; Fiscal Year: 2007
    ....
  9. Real-time Minimal Residual Disease assay of Pediatric B-Cell Non-Hodgkin Lymphoma
    Bruce Shiramizu; Fiscal Year: 2007
    ..The assay developed by this exploratory proposal could be incorporated into pediatric B-cell NHL studies to assess MRD on therapy or to assess the efficacy of innovative therapies. [unreadable] [unreadable] [unreadable]..
  10. SPAN-Xb as an immunologic target for CML
    SEAH LIM; Fiscal Year: 2007
    ..Successful completion of the proposal will therefore provide the basis for the clinical translation of SPAN-Xb. [unreadable] [unreadable]..
  11. Glutathione, macrophages and unstable atherosclerosis
    Michael Rosenfeld; Fiscal Year: 2007
    ..abstract_text> ..
  12. Brief Focused Treatment for TMD: Mechanisms of Action
    Mark Litt; Fiscal Year: 2007
    ..abstract_text> ..
  13. Computerized Decision Support System for Depression
    Madhukar Trivedi; Fiscal Year: 2007
    ..Comparisons will be made between CDSS-D, PPA-D, and UC-D. [unreadable] [unreadable]..
  14. Early Randomized Surgical Epilepsy Trial
    Jerome Engel; Fiscal Year: 2007
    ..abstract_text> ..
  15. ADULT AIDS CLINICAL TRIALS UNIT
    John Bartlett; Fiscal Year: 2006
    ..The applicants anticipate that Duke will continue as an efficient, cost-effective ACTU that contributes to the ACTG scientific agenda. ..
  16. Morphine versus Methadone as First Line Strong Opioid for Cancer Pain
    Eduardo Bruera; Fiscal Year: 2009
    ..and opioid metabolite accumulation will result in less frequent opioid induced toxicity, dose escalation and treatment failure, and therefore, improved quality of life...
  17. TREATMENT OF SSRI-RESISTANT DEPRESSION IN ADOLESCENTS
    Graham Emslie; Fiscal Year: 2006
    ..This site is based in Pittsburgh, which also serves as the Data Coordinating Center for the study [unreadable] [unreadable]..
  18. Treatment of Adolescent Suicide Attempters in Dallas
    Graham Emslie; Fiscal Year: 2006
    ..This exemplary protocol stimulated the formation of a collaborative group of 8 RUPP-PI applicants. By creating the protocol, the group forged an ability to work together. ..
  19. MECHANISMS OF SMOOTH MUSCLE HYPERREACTIVITY ON ASTHMA
    Prescott Woodruff; Fiscal Year: 2006
    ..The candidate will complement these studies with a curriculum of advanced training in methods for the design and analysis of gene expression studies in human subjects. ..
  20. International Clinical Trials Unit
    John Bartlett; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  21. Clinical Activity of 17-AAG in Lymphoma
    Anas Younes; Fiscal Year: 2007
    ..In Aim 3 we will correlate the biologic effects of 17-AAG and clinical response in patients with relapsed MCL, ALCL, and HL. [unreadable] [unreadable] [unreadable]..
  22. Using MEPS Data to Inform Public-Plan Consumerism
    Matthew Davis; Fiscal Year: 2007
    ..Findings will have immediate relevance for implementation of the HOA projects and other consumerism efforts. [unreadable] [unreadable] [unreadable]..
  23. Structure-function of inositol trisphosphate receptor
    Ilya Bezprozvanny; Fiscal Year: 2009
    ..Dopamine-induced responses in striatal medium spiny neurons will be studied by Ca2+ imaging. Experiments with striatal neurons from DARPP-32 and D2 receptor knockout mice will be performed. ..
  24. Meta-analysis of GWAS data to identify novel rheumatoid arthritis risk loci
    Robert M Plenge; Fiscal Year: 2010
    ..In addition, genetics should provide insight into important steps of the disease pathway, allowing for the development of new therapies that target these pathways in at-risk individuals. ..
  25. STATISTICAL PROBLEMS IN MULTIVARIATE SURVIVAL ANALYSIS
    Jianwen Cai; Fiscal Year: 2010
    ..This research will provide valuable new tools to cardiovascular disease researchers and other biomedical researchers. It will help the researchers to better understand the risk factors associated with cardiovascular diseases. ..
  26. Targeting Inflammation to Improve Endothelial Function in Type 2 Diabetes: A Subs
    Mark A Creager; Fiscal Year: 2010
    ..End of Abstract) ..
  27. HTS Screen for Small Molecule Inhibitors of Mint-PDZ Domain
    Ilya Bezprozvanny; Fiscal Year: 2008
    ..Generated molecules may also serve as useful probes for studies of synaptic function of N-type Ca2+ channels. [unreadable] [unreadable] [unreadable]..
  28. MOLECULAR BASIS OF HIGH DENSITY LIPOPROTEIN DEFICIENCY
    ERNST SCHAEFER; Fiscal Year: 2009
    ..The results of this work will provide important insight into the contribution of allelic variation in the pathways of HDL metabolism, inflammation, and insulin resistance to the complex phenotype of low HDL-C. ..
  29. Presenilins and neuronal calcium signaling
    ILYA B BEZPROZVANNY; Fiscal Year: 2010
    ..These data will also help to evaluate "Ca2+ hypothesis of AD" and will contribute to selecting optimal strategies for treatment of AD. ..
  30. Combined Pharmacotherapies for Cocaine Dependence
    Frances Levin; Fiscal Year: 2008
    ..3. To explore a set of related secondary outcomes (treatment retention, global functioning, and HIV risk behavior) as well as moderators and mediators potentially reflective of mechanism of action. [unreadable] [unreadable] [unreadable]..
  31. Cleveland Clinic Orthopaedic Research Training Grant
    JOSEPH IANNOTTI; Fiscal Year: 2008
    ..abstract_text> ..
  32. Modifiers of Cancer Risk in BRCA 1/2 Mutation Carriers
    Timothy Rebbeck; Fiscal Year: 2008
    ..Our substantial multidisciplinary experience will therefore allow us to readily translate basic science and epidemiological data to clinically relevant information. ..
  33. Targeting HIF-1alpha in renal cell carcinoma: the role of HDAC inhibitors
    Roberto Pili; Fiscal Year: 2010
    ....
  34. Phase II Clinical Trial Utilizing Lithium for Patients with Neuroendocrine Tumors
    Herbert Chen; Fiscal Year: 2008
    ..Besides surgery, there are limited curative and palliative treatments available to patients with metastatic NE tumors, emphasizing the need for development of other forms of therapy. [unreadable] [unreadable] [unreadable]..
  35. Long-term efficacy of pediatric HAART
    DALTON CHEKOKO WAMALWA; Fiscal Year: 2010
    ..This study will provide important information on effectiveness of HAART regimens being scaled up in resource-poor countries and help programs better plan for changes of drug regimens following treatment failure.
  36. Mapping HIV/AIDS genes with haplotype-based strategies
    Robert Plenge; Fiscal Year: 2008
    ..These studies hope to identify novel genes that influence susceptibility to HIV/AIDS, thereby providing insight into HIV/AIDS pathogenesis and, ultimately, improving patient care. ..
  37. Dietary Omega-3 Fatty Acids and Sudden Cardiac Death
    GEORGE EDWARD BILLMAN; Fiscal Year: 2010
    ..This project will also determine the effectiveness of fish oil supplements in reducing sudden death due to a lethal abnormal heart rhythm after a heart attack. ..
  38. DIETARY COMPOSITION, OBESITY, AND CARDIOVASCULAR RISK
    ERNST SCHAEFER; Fiscal Year: 2003
    ..abstract_text> ..
  39. 1H MRSI OF AMYOTROPHIC LATERAL SCLEROSIS
    Michael Weiner; Fiscal Year: 2002
    ..abstract_text> ..
  40. Screen:Blockers of a CaV2.2-Mint-PDZ1 association (RMI)
    Ilya Bezprozvanny; Fiscal Year: 2004
    ..Biological activity of compounds identified in the full HTS screen will be tested in whole animal pain assays (formalin, hot plate, tail flick). ..
  41. Marijuana Abusing ADHD Teens: Atomoxetine Treatment
    Frances Levin; Fiscal Year: 2004
    ..4. To examine the relationship between medication treatment, reduction in ADHD symptoms, and improvement in retention and/or progress in treatment using mediational analyses. ..
  42. Characteristics and Costs of Impaired Fasting Glucose
    Gregory Nichols; Fiscal Year: 2005
    ..Finally, we will calculate and compare the costs of medical care for patients in each FPG stage, and estimate multivariate models to identify factors that contribute to medical costs in each stage. ..
  43. Clinical Approaches to Ileal Pouch Dysfunction
    Bo Shen; Fiscal Year: 2005
    ..The AIMS of study are to 1) investigate visceral hypersensitivity using barostat examination of the pouch; 2) conduct a randomized, placebo-controlled clinical trial evaluating the use of amitriptyline in IPS. ..
  44. METHYLPHENIDATE TREATMENT FOR COCAINE ABUSE AND ADHD
    Frances Levin; Fiscal Year: 2002
    ..2) To determine if sustained-release MPH is more effective than placebo in reducing ADHD symptoms in cocaine abusers with adult ADHD. 3) To determine if improvement in ADHD symptoms precedes a reduction in cocaine use. ..
  45. Cardiac-Related Mortality with Atypical Antipsychotics
    DEANNA KELLY; Fiscal Year: 2005
    ..This study is important as data on long-term health outcomes with atypical antipsychotics is lacking from the literature. ..
  46. Role of Somatostatin Receptors in Pancreatic Cancer
    William Fisher; Fiscal Year: 2003
    ..Since somatostatin expression has been demonstrated in other tumor types, the findings may also be relevant to other cancers. ..
  47. Role of Glycogen Synthase Kinase 3 In Type 2-Diabetes
    Robert Henry; Fiscal Year: 2004
    ..abstract_text> ..
  48. RESPIRATORY DISEASES/BSI STUDY
    Shahin Lockman; Fiscal Year: 2004
    ....
  49. K24 MID-CAREER CLINICAL INVESTIGATOR AWARD
    John Bartlett; Fiscal Year: 2004
    ..His immediate research objectives include the investigation of antiretroviral treatment failure, and efforts to diminish the reservoir of chronically HIV-infected cells in persons receiving antiretroviral ..
  50. Signaling Pathways in Hepatic Fibrogenesis
    Bruce Bacon; Fiscal Year: 2005
    ..Since activated HSC play a key role in hepatic fibrogenesis, these experiments will contribute to an improved understanding of the basic biochemical processes underlying hepatic fibrosis. ..
  51. Are Volume Standards Accurate Measures of Quality?
    Laurent Glance; Fiscal Year: 2005
    ..abstract_text> ..
  52. Mechanisms of Steroid Resistance in Severe Asthma
    William Calhoun; Fiscal Year: 2005
    ..abstract_text> ..
  53. Addressing Light Smoking in African Americans
    Kolawole Okuyemi; Fiscal Year: 2006
    ..The research may provide crucial information to advance our understanding of smoking and set the stage for further research in this understudied population of AA cigarette smokers. ..
  54. Natural History of POP-- A Prospective Cohort Study
    Ingrid Nygaard; Fiscal Year: 2005
    ..The national cost burden is large. This project will provide fundamental data to guide future decisions about intervention threshold, preventative measures, and risk factor modification. ..
  55. Methylphenidate for Fatigue in Advanced Cancer Patients
    Eduardo Bruera; Fiscal Year: 2009
    ....
  56. Defibrotide for the treatment of severe hepatic veno-cc*
    Paul Richardson; Fiscal Year: 2007
    ..Abstract Not Provided ..
  57. COLUMBIA-ADARC-CORNELL AIDS CLINICAL TRIALS UNIT
    Scott Hammer; Fiscal Year: 2006
    ..Thus, the Columbia-ADARC ACTU will be an active participant in the Group's mission to improve the health of HIV infected individuals and set standards for treatment of HIV disease. ..
  58. HOMOCYSTEINE, INFLAMMATION, AND ATHEROGENESIS
    Michael Rosenfeld; Fiscal Year: 2001
    ..Under Aim 2, the investigator will determine the mechanism by which HC and lipid accumulation alter glutathione and NADH/NADPH metabolism, thereby activating macrophages in vitro. ..
  59. Varian 4 Tesla MRI/MRS for Neuro-degenerative Diseases
    Michael Weiner; Fiscal Year: 2002
    ..These expected results emphasize the practical outcome and significance of this research. ..
  60. AROUSAL AND ANXIETY IN DYSFUNCTIONAL MEN AND WOMEN
    David Barlow; Fiscal Year: 2001
    ..The purpose of this series of studies is to explore more precisely the role of cognitive and attentional processes specified in our model of sexual dysfunction. ..
  61. Glucose Regulation of Pancreatic Islet Gene Experession
    RODERICK PAUL ROBERTSON; Fiscal Year: 2010
    ..We will study whether increasing antioxidant protection protects these cells and prevents deterioration of glucose control in diabetes. ..
  62. The Genetic Basis of Human Tooth Agenesis
    Sylvia Frazier Bowers; Fiscal Year: 2006
    ..This research is central to the career goals of the applicant, which are to perform independent and original research that is relevant to identifying genetic factors that lead to orthodontic problems. ..
  63. Regulation of Bladder Smooth Muscle Hyperplasia
    Paul Austin; Fiscal Year: 2007
    ..Work of this nature may decrease the morbidity and mortality that is caused by bladder outlet obstruction. ..
  64. Improving Varenicline Adherence and Outcome in Homeless Smokers
    Kolawole S Okuyemi; Fiscal Year: 2010
    ....
  65. Hypoxia as a target for the treatment of brain tumors
    Erwin Van Meir; Fiscal Year: 2003
    ..The translation of these preclinical studies have the potential to directly benefit human health by improving the survival of children and adults with cancer. ..
  66. Basic Science of Tendon To Bone Healing
    Asheesh Bedi; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  67. THERAPEUTIC MODULATION OF ANGIOGENESIS IN HUMAN GLIOMAS
    Erwin G Van Meir; Fiscal Year: 2011
    ..Improving the treatment of malignant gliomas, an incurable disease, is an important human health goal. ..
  68. Treatment of Early Age Mania (TEAM)
    Graham Emslie; Fiscal Year: 2003
    ..D. (4) University of Texas, Dallas, PI: Graham Emslie, M.D. (5) University of Texas, Galveston, PI: Karen Dineen Wagner, M.D. and (6) Washington University, St. Louis, PI; Joan Luby, M.D. ..
  69. THE ROLE OF MYCOBACTERIA IN CROHN'S DISEASE
    David Graham; Fiscal Year: 2005
    ..The results of this study should either confirm or refute the proposed etiologic association of M. paratuberculosis and Crohn's disease as well as the identification of patients with Crohn's disease and M. paratuberculosis. ..
  70. Flavopiridol as a Potential Therapy in Multiple Myeloma
    Keith Bible; Fiscal Year: 2005
    ..Results of proposed studies will improve understanding of the effects and mechanism(s) of action of flavopiridol in myeloma cells, thereby potentially contributing to the further clinical development of the drug. ..
  71. Effects of Menthol on Bupropion Pharmacokinetics
    Kolawole Okuyemi; Fiscal Year: 2006
    ..abstract_text> ..
  72. Flavopiridol Targets Transcription Factor/DNA Complexes
    Keith Bible; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  73. ACISR - Early-Onset Mood & Anxiety Disorder
    David Brent; Fiscal Year: 2006
    ..The Center will enhance the development of the next generation of intervention and services researchers and will disseminate new research information to families, practitioners, and researchers. ..
  74. Oxidative Stress and Genetics of Prehypertension
    Shawna Nesbitt; Fiscal Year: 2004
    ..abstract_text> ..
  75. TREATMENT OF PANIC DISORDER--LONG TERM STRATEGIES
    David Barlow; Fiscal Year: 2003
    ..These sites already have in place the trained and certified assessment and treatment personnel and rigorous monitoring procedures that are essential for the conduct of a study such as the one we propose. ..
  76. A Unified Treatment for Anxiety Disorders
    David Barlow; Fiscal Year: 2008
    ..If successful, this will be the first step towards a large scale treatment study validating a unified psychosocial approach to the emotional disorders. ..
  77. Novel Therapies for High-Risk Neuroblastoma
    Julie Park; Fiscal Year: 2006
    ..abstract_text> ..
  78. A hypoxia-dependent adenovirus for glioma therapy
    Erwin Van Meir; Fiscal Year: 2005
    ..The translation of these preclinical studies have the potential to directly benefit human health by improving the survival of cancer patients. ..
  79. Hyperglycemia, Frailty and Disability in Older Women
    Caroline Blaum; Fiscal Year: 2006
    ..abstract_text> ..
  80. Phase II Study of 44Gy from 131I-81C6 for CNS Tumors
    David Reardon; Fiscal Year: 2004
    ..To further define the toxicity of this approach and Specific Aim 3.To determine the impact of this therapy on quality of life. ..
  81. Immunologic Control of Drug-resistant HIV-1
    Steven Deeks; Fiscal Year: 2005
    ..Finally, since we will estimate the relative in vivo thresholds for HIV-mediated immunogenicity and pathogenicity, these studies may also have implications for vaccine development. ..
  82. Structure Function Analysis of TB Pyrazinamidase
    Ying Zhang; Fiscal Year: 2005
    ..These studies will provide important information about mechanisms of PZA action and resistance and may help design new antituberculosis drugs. ..
  83. Treatment Intensification for Drug-Resistant HIV
    Steven Deeks; Fiscal Year: 2004
    ..Funding for the pilot clinical trial has been obtained from other sources; funding is requested in this proposal only for costs associated with the measurements of immunologic response to drug-resistant HIV-1. ..
  84. TREATMENT OF SSRI-RESISTANT DEPRESSION IN ADOLESCENTS
    David Brent; Fiscal Year: 2006
    ..This site is based in Pittsburgh, which also serves as the Data Coordinating Center for the study [unreadable] [unreadable]..