sperm count

Summary

Summary: A count of SPERM in the ejaculum, expressed as number per milliliter.

Top Publications

  1. ncbi Sperm morphology, motility, and concentration in fertile and infertile men
    D S Guzick
    Department of Obstetrics and Gynecology, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    N Engl J Med 345:1388-93. 2001
  2. ncbi Male fertility in natural populations of red deer is determined by sperm velocity and the proportion of normal spermatozoa
    Aurelio F Malo
    Reproductive Ecology and Biology Group, Museo Nacional de Ciencias Naturales CSIC, 28006 Madrid, Spain
    Biol Reprod 72:822-9. 2005
  3. ncbi Reproductive effects in male rats exposed to diuron
    Glaura S A Fernandes
    Departamento de Biologia Celular, Instituto de Biologia, Universidade Estadual de Campinas UNICAMP, Campinas, SP, Brazil
    Reprod Toxicol 23:106-12. 2007
  4. ncbi Time to pregnancy and semen parameters: a cross-sectional study among fertile couples from four European cities
    R Slama
    INSERM U292, Research in Public Health, 82 rue du General Leclerc, 94276 Le Kremlin Bicetre Cedex, France
    Hum Reprod 17:503-15. 2002
  5. ncbi Sirolimus may reduce fertility in male renal transplant recipients
    J Zuber
    Department of Kidney Transplantation, Necker Hospital, Paris, France
    Am J Transplant 8:1471-9. 2008
  6. pmc BMI in relation to sperm count: an updated systematic review and collaborative meta-analysis
    N Sermondade
    Service d Histologie Embryologie Cytogénétique CECOS, Hopital Jean Verdier AP HP, Bondy, France
    Hum Reprod Update 19:221-31. 2013
  7. ncbi Genome-wide sperm deoxyribonucleic acid methylation is altered in some men with abnormal chromatin packaging or poor in vitro fertilization embryogenesis
    Kenneth I Aston
    Andrology and IVF Laboratories, Department of Surgery, University of Utah School of Medicine, Salt Lake City, Utah 84108, USA
    Fertil Steril 97:285-92. 2012
  8. ncbi Male obesity and alteration in sperm parameters
    Ahmad O Hammoud
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Utah, School of Medicine, Salt Lake City, Utah 84132, USA
    Fertil Steril 90:2222-5. 2008
  9. ncbi Testicular toxicity in mercuric chloride treated rats: association with oxidative stress
    Mohamed Ali Boujbiha
    Laboratory of Ecophysiology of Animals, Faculty of Sciences, 3018 Sfax, BP 802, Tunisia
    Reprod Toxicol 28:81-9. 2009
  10. ncbi Lower sperm counts following prenatal tobacco exposure
    M S Jensen
    Department of Occupational Medicine, Aarhus University Hospital, Aarhus Sygehus, Denmark
    Hum Reprod 20:2559-66. 2005

Detail Information

Publications271 found, 100 shown here

  1. ncbi Sperm morphology, motility, and concentration in fertile and infertile men
    D S Guzick
    Department of Obstetrics and Gynecology, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    N Engl J Med 345:1388-93. 2001
    ..Although semen analysis is routinely used to evaluate the male partner in infertile couples, sperm measurements that discriminate between fertile and infertile men are not well defined...
  2. ncbi Male fertility in natural populations of red deer is determined by sperm velocity and the proportion of normal spermatozoa
    Aurelio F Malo
    Reproductive Ecology and Biology Group, Museo Nacional de Ciencias Naturales CSIC, 28006 Madrid, Spain
    Biol Reprod 72:822-9. 2005
    ..We conclude that male fertility varies substantially in natural populations of Iberian red deer and that, when sperm numbers are equal, it is determined mainly by sperm swimming velocity and sperm morphology...
  3. ncbi Reproductive effects in male rats exposed to diuron
    Glaura S A Fernandes
    Departamento de Biologia Celular, Instituto de Biologia, Universidade Estadual de Campinas UNICAMP, Campinas, SP, Brazil
    Reprod Toxicol 23:106-12. 2007
    ....
  4. ncbi Time to pregnancy and semen parameters: a cross-sectional study among fertile couples from four European cities
    R Slama
    INSERM U292, Research in Public Health, 82 rue du General Leclerc, 94276 Le Kremlin Bicetre Cedex, France
    Hum Reprod 17:503-15. 2002
    ..In fertile populations, little is known about the association between semen parameters and time to pregnancy (TTP)...
  5. ncbi Sirolimus may reduce fertility in male renal transplant recipients
    J Zuber
    Department of Kidney Transplantation, Necker Hospital, Paris, France
    Am J Transplant 8:1471-9. 2008
    ..Patients treated with sirolimus throughout the post-transplant period had a significantly reduced total sperm count compared to patients who did not receive sirolimus (28.6 +/- 31.2 x 10(6) and 292.2 +/- 271...
  6. pmc BMI in relation to sperm count: an updated systematic review and collaborative meta-analysis
    N Sermondade
    Service d Histologie Embryologie Cytogénétique CECOS, Hopital Jean Verdier AP HP, Bondy, France
    Hum Reprod Update 19:221-31. 2013
    ..The purpose of this report was to update the evidence on the association between BMI and sperm count through a systematic review with meta-analysis...
  7. ncbi Genome-wide sperm deoxyribonucleic acid methylation is altered in some men with abnormal chromatin packaging or poor in vitro fertilization embryogenesis
    Kenneth I Aston
    Andrology and IVF Laboratories, Department of Surgery, University of Utah School of Medicine, Salt Lake City, Utah 84108, USA
    Fertil Steril 97:285-92. 2012
    ..To evaluate genome-wide DNA methylation patterns in sperm from men with abnormal sperm chromatin packaging and patients displaying abnormal embryogenesis after IVF in the absence of known female factors...
  8. ncbi Male obesity and alteration in sperm parameters
    Ahmad O Hammoud
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Utah, School of Medicine, Salt Lake City, Utah 84132, USA
    Fertil Steril 90:2222-5. 2008
    ..To study the effect of male obesity on sperm parameters and erectile dysfunction...
  9. ncbi Testicular toxicity in mercuric chloride treated rats: association with oxidative stress
    Mohamed Ali Boujbiha
    Laboratory of Ecophysiology of Animals, Faculty of Sciences, 3018 Sfax, BP 802, Tunisia
    Reprod Toxicol 28:81-9. 2009
    ..Cauda epididymal sperm count/motility decreased significantly in the mercury-treated group and qualitative examination of testicular ..
  10. ncbi Lower sperm counts following prenatal tobacco exposure
    M S Jensen
    Department of Occupational Medicine, Aarhus University Hospital, Aarhus Sygehus, Denmark
    Hum Reprod 20:2559-66. 2005
    ..To extend the research on this hypothesis we investigated the dose-dependency of the association, controlling for other prenatal exposures...
  11. pmc Sperm competition dynamics: ejaculate fertilising efficiency changes differentially with time
    Tommaso Pizzari
    Edward Grey Institute, Department of Zoology, University of Oxford, Oxford, UK
    BMC Evol Biol 8:332. 2008
    ..The differential rate at which rival ejaculates lose their fertilising efficiency over time is therefore expected to influence the outcome of sperm competition...
  12. ncbi Impaired Leydig cell function in infertile men: a study of 357 idiopathic infertile men and 318 proven fertile controls
    A M Andersson
    Department of Growth and Reproduction, Copenhagen University Hospital, Section GR 5064, Blegdamsvej 9, DK 2100 Copenhagen OE, Denmark
    J Clin Endocrinol Metab 89:3161-7. 2004
    ..On the other hand, the parallel impairment of spermatogenesis and Leydig cells may reflect a congenital dysfunction of both compartments caused by a testicular dysgenesis during fetal/infant development...
  13. ncbi The frequency of multiple paternity predicts variation in testes size among island populations of house mice
    R C Firman
    Centre for Evolutionary Biology, School of Animal Biology M092, The University of Western Australia, Nedlands, WA, Australia
    J Evol Biol 21:1524-33. 2008
    ..However, variation in sperm traits was not explained by sperm competition risk. We discuss these findings in relation to sperm competition theory, and other intrinsic and extrinsic factors that might influence ejaculate quality...
  14. ncbi Semen quality of male smokers and nonsmokers in infertile couples
    Robert Künzle
    Department of Obstetrics and Gynaecology, University of Berne, Berne, Switzerland
    Fertil Steril 79:287-91. 2003
    ..To investigate the effect of cigarette smoking on main sperm variables...
  15. ncbi Regional differences in semen quality in Europe
    N Jørgensen
    Department of Growth and Reproduction, Rigshospitalet, The Juliane Marie Centre, Copenhagen, Denmark
    Hum Reprod 16:1012-9. 2001
    ..A general seasonal variation in sperm concentration (summer 70% of winter) and total sperm count (summer 72% of winter) was detected...
  16. pmc Diet-induced obesity in male mice is associated with reduced fertility and potentiation of acrylamide-induced reproductive toxicity
    Burhan I Ghanayem
    Laboratory of Pharmacology, Biostatistics Branch, and Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Biol Reprod 82:96-104. 2010
    ..This work demonstrated that diet-induced obesity in mice caused a significant reduction in male fertility and exacerbated AA-induced reproductive toxicity and germ cell mutagenicity...
  17. ncbi Is prenatal exposure to tobacco smoking a cause of poor semen quality? A follow-up study
    Cecilia Høst Ramlau-Hansen
    Department of Occupational Medicine, Aarhus University Hospital, Aarhus, Denmark
    Am J Epidemiol 165:1372-9. 2007
    ..The authors found an inverse association between maternal smoking during pregnancy and total sperm count (p = 0.002)...
  18. ncbi East-West gradient in semen quality in the Nordic-Baltic area: a study of men from the general population in Denmark, Norway, Estonia and Finland
    Niels Jørgensen
    Department of Growth and Reproduction, Rigshospitalet, The Juliane Marie Centre, Copenhagen, Denmark
    Hum Reprod 17:2199-208. 2002
    ....
  19. ncbi Dietary supplementation with a source of omega-3 fatty acids increases sperm number and the duration of ejaculation in boars
    M J Estienne
    Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Theriogenology 70:70-6. 2008
    ....
  20. ncbi DNA methylation in spermatozoa as a prospective marker in andrology
    R Klaver
    Institute of Reproductive and Regenerative Biology, Centre of Reproductive Medicine and Andrology, University Clinics of Münster, Germany
    Andrology 1:731-40. 2013
    ..aberration was found to be significantly associated with bi-testicular volume, sperm concentration and total sperm count. DNA methylation in normozoospermic volunteers was stable over a time period of up to 951 days in contrast to ..
  21. ncbi An aminoglycoside antibiotic gentamycin induces oxidative stress, reduces antioxidant reserve and impairs spermatogenesis in rats
    Kilarkaje Narayana
    Department of Anatomy, Faculty of Medicine, HSC, Kuwait University, Safat, Kuwait
    J Toxicol Sci 33:85-96. 2008
    ..The sperm count, sperm motility and incidence of abnormal sperms were estimated in the epididymis...
  22. ncbi Effect of ascorbic acid and Vitamin E supplementation on semen quality and biochemical parameters of male rabbits
    M I Yousef
    Department of Environmental Studies, Institute of Graduate Studies and Research, Alexandria University, 163 Horreya Avenue, P O Box 832, Alexandria 21526, Egypt
    Anim Reprod Sci 76:99-111. 2003
    ..E and their combination reduced the production of free radicals and can improve rabbit semen quality, but the greater improvement seemed to be from Vit. E...
  23. ncbi Effects of Chlorophytum borivilianum on sexual behaviour and sperm count in male rats
    Rakesh Kenjale
    Department of Pharmaceutical Sciences, Mumbai University Institute of Chemical Technology, Matunga, Mumbai 400019, India
    Phytother Res 22:796-801. 2008
    ..For sperm count the treatment was continued further in all groups except the Viagra((R)) group for 60 days...
  24. ncbi Impact of body mass index values on sperm quantity and quality
    Hilton I Kort
    Reproductive Biology Associates, 1150 Lake Hearn Drive, Suite 400, Atlanta, GA 30342, USA
    J Androl 27:450-2. 2006
    ..Men presenting with a BMI greater than 25 kg/m(2) have fewer chromatin-intact normal-motile sperm cells per ejaculate. Therefore, to ensure maximum fertility potential, patients may be advised to reduce body weight...
  25. ncbi Idiopathic male infertility is strongly associated with aberrant methylation of MEST and IGF2/H19 ICR1
    A Poplinski
    Centre of Reproductive Medicine and Andrology, 48149 Munster, Germany
    Int J Androl 33:642-9. 2010
    ..The male germ cell thus represents a potential source for aberrant epigenetic features in children conceived via ART...
  26. ncbi Male reproductive system parameters in a two-generation reproduction study of ammonium perfluorooctanoate in rats and human relevance
    Raymond G York
    WIL Research Laboratories, 1407 George Road, Ashland, OH 44805 8946, United States
    Toxicology 271:64-72. 2010
    ....
  27. ncbi Dietary supplementation of antioxidants improves semen quality of IVF patients in terms of motility, sperm count, and nuclear vacuolization
    Barbara Wirleitner
    IVF Centers Prof Zech, Bregenz, Austria
    Int J Vitam Nutr Res 82:391-8. 2012
    ....
  28. ncbi Impact of male obesity on infertility: a critical review of the current literature
    Ahmad O Hammoud
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Utah School of Medicine, Salt Lake City, Utah 84108, USA
    Fertil Steril 90:897-904. 2008
    ..To evaluate the current understanding of the effects and potential mechanisms of obesity on male fertility...
  29. ncbi Impairment of spermatogenesis in rats by methylmercury: involvement of stage- and cell- specific germ cell apoptosis
    S Homma-Takeda
    Graduate School Doctoral Program in Medical Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Toxicology 169:25-35. 2001
    ..Our results suggest that methylmercury impairs spermatogenesis by germ cell deletion via cell- and stage- specific apoptosis...
  30. pmc Concentrations of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) and their associations with human semen quality measurements
    James H Raymer
    RTI International, 3040 Cornwallis Road, P O Box 12194, Research Triangle Park, NC 27709, United States
    Reprod Toxicol 33:419-27. 2012
    ..Luteinizing hormone was positively correlated with plasma PFOA and PFOS, but not semen PFOS. Important methodological concerns included the lack of multiple hormonal measurements necessary to address circadian rhythms...
  31. ncbi An effective method for freezing White Italian gander semen
    Ewa Lukaszewicz
    Poultry Breeding Department, Agricultural University of Wrocław, Poland
    Theriogenology 58:19-27. 2002
    ....
  32. ncbi Propolis protection from reproductive toxicity caused by aluminium chloride in male rats
    Mokhtar I Yousef
    Department of Home Economic, Faculty of Specific Education, Alexandria University, 14 Mohamed Amin Shohaib Street, Moustafa Kamel, P O Box Roushdi, Alexandria 21529, Egypt
    Food Chem Toxicol 47:1168-75. 2009
    ..This was proved histopathologically by the great improvement in testes. In conclusion propolis could be effective in the protection against the reproductive toxicity of AlCl3...
  33. ncbi Protective action of vitamins on the spermatogenesis in lead-treated Swiss mice
    Monalisa Mishra
    Department of Zoology, Berhampur University, Orissa 760001, India
    J Trace Elem Med Biol 18:173-8. 2004
    The protective action of vitamins C and E against lead acetate-induced reduced sperm count and sperm abnormalities in Swiss mice has been studied...
  34. pmc Dicer1 depletion in male germ cells leads to infertility due to cumulative meiotic and spermiogenic defects
    Yannick Romero
    Department of Genetic Medicine and Development, University of Geneva Medical School, University of Geneva, Geneva, Switzerland
    PLoS ONE 6:e25241. 2011
    ..In this study, we investigated to which extent DICER1 is required for germ cell development and the progress of spermatogenesis in mice...
  35. ncbi Aluminium-induced deterioration in reproductive performance and seminal plasma biochemistry of male rabbits: protective role of ascorbic acid
    Mokhtar I Yousef
    Department of Environmental Studies, Institute of Graduate Studies and Research, Alexandria University, 163 Horreya Avenue, P O Box 832, Alexandria 21526, Egypt
    Toxicology 215:97-107. 2005
    ..It was suggested that AlCl3 exerted a significant adverse effect on reproductive performance of male rabbits. Furthermore, AA could be able to antagonize the toxic effects of AlCl3 and improved semen quality of male rabbit...
  36. ncbi A multicenter contraceptive efficacy study of injectable testosterone undecanoate in healthy Chinese men
    Yi Qun Gu
    National Research Institute for Family Planning, Beijing 100081, China
    J Clin Endocrinol Metab 88:562-8. 2003
    ..The results showed that monthly TU injection at a dose of 500 mg after an initial loading dose of 1000 mg can effectively, safely, and reversibly suppress spermatogenesis in healthy Chinese men without serious adverse effects...
  37. ncbi How work-place conditions, environmental toxicants and lifestyle affect male reproductive function
    Jens Peter Bonde
    Department of Occupational Medicine, Aarhus University Hospital, Aarhus, Denmark
    Int J Androl 25:262-8. 2002
    ..male reproductive function are known but exposure prevalences are hardly sufficient to play a role for reduced sperm count in the general male population. Sedentary work may be an exception...
  38. pmc Dioxin-induced changes in epididymal sperm count and spermatogenesis
    Warren G Foster
    Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    Environ Health Perspect 118:458-64. 2010
    ..A single in utero exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on gestation day 15 decreased epididymal sperm count in adult rats and thus was used to establish a tolerable daily intake for TCDD...
  39. pmc Effects of chronic exposure to sodium arsenite on hypothalamo-pituitary-testicular activities in adult rats: possible an estrogenic mode of action
    Kuladip Jana
    Department of Veterinary Surgery and Radiology, West Bengal University of Animal and Fishery Sciences, 37 and 68, K B Sarani, Calcutta 700 037, West Bengal, India
    Reprod Biol Endocrinol 4:9. 2006
    ..In this context, we evaluated the mode of action of chronic oral exposure of sodium arsenite on hypothalamo-pituitary- testicular activities in mature male albino rats...
  40. ncbi Geographical differences in semen quality in a population of young healthy volunteers from the different regions of Spain
    M López-Teijón
    Servico de Reproducción, Instituto Marqués, Barcelona, Spain
    Andrologia 40:318-28. 2008
    ..These results support the hypothesis that exposure to environmental toxicants may affect the process of spermatogenesis leading to meiotic alterations, maturational arrest and oligospermia...
  41. ncbi Experimental evolution of sperm count in protandrous self-fertilizing hermaphrodites
    Rosalind L Murray
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON M5S3B2, Canada
    J Exp Biol 214:1740-7. 2011
    b>Sperm count evolution is driven by sexual selection, with an added role of selection on gamete resource allocation for hermaphrodite spermatogenesis...
  42. ncbi Fermentation filtrates of Rubus coreanus relax the corpus cavernosum and increase sperm count and motility
    Jeong Hee Jeon
    College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University, Chungbuk, Republic of Korea
    J Med Food 11:474-8. 2008
    ..coreanus have positive effects on the function of the male reproductive system by triggering a penile erection, enhancing serum testosterone levels, and increasing epididymal sperm counts...
  43. pmc The relative nature of fertilization success: implications for the study of post-copulatory sexual selection
    Francisco Garcia-Gonzalez
    Centre for Evolutionary Biology, School of Animal Biology M092, The University of Western Australia, Nedlands, WA 6009, Australia
    BMC Evol Biol 8:140. 2008
    ....
  44. ncbi Body mass index in relation to semen quality and reproductive hormones among 1,558 Danish men
    Tina Kold Jensen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Fertil Steril 82:863-70. 2004
    ..To examine the relationship between body mass index (BMI) and semen quality among young men from the general population...
  45. ncbi Experimental evidence for the evolution of numerous, tiny sperm via sperm competition
    Matthew J G Gage
    Centre for Ecology, Evolution and Conservation, School of Biological Sciences, University of East Anglia, Norwich NR47TJ, United Kingdom
    Curr Biol 13:754-7. 2003
    ..However, our study does not explain why G. bimaculatus sperm length persists naturally at approximately 1 mm; we discuss possibilities for this sperm size maintenance...
  46. ncbi Coordinated European investigations of semen quality: results from studies of Scandinavian young men is a matter of concern
    Niels Jørgensen
    University Department of Growth and Reproduction, Rigshospitalet, DK 2100 Copenhagen, Denmark
    Int J Androl 29:54-61; discussion 105-8. 2006
    ..In Denmark, the situation is of concern and a continued surveillance of semen quality in young men was established in 2001 by a government-supported programme...
  47. ncbi Relationships between serum hormone levels and semen quality among men from an infertility clinic
    John D Meeker
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI 48109, and Vincent Memorial Obstetrics and Gynecology Service, Massachusetts General Hospital, Boston, USA
    J Androl 28:397-406. 2007
    ..Additional consideration should be given to the utility of serum hormone levels as a surrogate for semen quality in epidemiologic studies in which the collection of semen is difficult due to logistical and/or volunteer rate constraints...
  48. ncbi Is overweight a risk factor for reduced semen quality and altered serum sex hormone profile?
    Anette S Aggerholm
    Department of Occupational Medicine, Aarhus University Hospital, Aarhus, Denmark
    Fertil Steril 90:619-26. 2008
    ..To evaluate whether overweight and obesity are related to changes in serum sex hormone concentrations and semen quality...
  49. ncbi Protective effect of vitamin E against mercuric chloride reproductive toxicity in male mice
    M V Rao
    Reproductive Endocrinology and Toxicology Division, Department of Zoology, School of Sciences, Gujarat University, Ahmedabad 380009, India
    Reprod Toxicol 15:705-12. 2001
    ..Parameters studied included serum testosterone, epididymal sperm count, motility, and morphology, epididymal and vas deferens adenosine triphosphatase (ATPase), phosphorylase, sialic ..
  50. ncbi Reproductive functions of the ageing male
    Bianca Kühnert
    Institute of Reproductive Medicine of the University, Domagkstr 11, D 48129 Muenster, Germany
    Hum Reprod Update 10:327-39. 2004
    ..However, even if the genetic risk for progeny from older fathers is slightly increased, the risk to the individual is low...
  51. ncbi Novel method for the cryopreservation of testicular sperm and ejaculated spermatozoa from patients with severe oligospermia: a pilot study
    Alexander Just
    Department of Gynecology and Obstetrics, IVF Outpatient Department, General Hospital of St Pölten, Probst Fuhrer Strasse 4, A 3100 St Pölten, Austria
    Fertil Steril 82:445-7. 2004
    ..To investigate Volvox globator as an easy-to-handle vehicle and as a safe alternative for cryopreservation of functional motile sperm cells...
  52. pmc Dioxin exposure, from infancy through puberty, produces endocrine disruption and affects human semen quality
    Paolo Mocarelli
    University Department of Laboratory Medicine, Hospital of Desio, Milano, Italy
    Environ Health Perspect 116:70-7. 2008
    ..In 1976 an accident exposed residents in Seveso, Italy, to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)...
  53. ncbi Abnormally high body mass index and tobacco use are associated with poor sperm quality as revealed by reduced sperm binding to hyaluronan-coated slides
    Carole C Wegner
    Center for Reproductive Biology of Indiana, Indianapolis, Indiana 46280, USA
    Fertil Steril 93:332-4. 2010
    ....
  54. pmc In utero protein restriction causes growth delay and alters sperm parameters in adult male rats
    Fabiola C Toledo
    Graduate Program in Cell and Structural Biology, Institute of Biology, University of Campinas UNICAMP, Campinas, SP, Brazil
    Reprod Biol Endocrinol 9:94. 2011
    ..The possible effects of in utero protein restriction on sexual development of rat male offspring were evaluated in the present study...
  55. ncbi Prevention of oxidative stress injury to sperm
    Ashok Agarwal
    Center for Advanced Research in Human Reproduction, Infertility and Sexual Function, Glickman Urological Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Androl 26:654-60. 2005
  56. ncbi Anti-Müllerian hormone in men with normal and reduced sperm concentration and men with maldescended testes
    Frank Tüttelmann
    Institute of Reproductive Medicine of the University, Munster, Germany
    Fertil Steril 91:1812-9. 2009
    ....
  57. ncbi Association between mental stress & some antioxidant enzymes of seminal plasma
    Sevgi Eskiocak
    Department of Biochemistry, Trakya University, School of Medicine Edirne, Turkey
    Indian J Med Res 122:491-6. 2005
    ..In the present study, we investigated the effect of mental stress due to final exams on two important antioxidant enzymes of the seminal plasma, superoxide dismutase (SOD) and catalase in normal healthy medical students...
  58. ncbi Obesity and male reproductive potential
    Ahmad O Hammoud
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City, Utah 84108, USA
    J Androl 27:619-26. 2006
  59. ncbi Good semen quality and life expectancy: a cohort study of 43,277 men
    Tina Kold Jensen
    Department of Environmental Medicine, Institute of Public Health, University of Southern Denmark, Winsloewsparken 17, 5000 Odense C, Denmark
    Am J Epidemiol 170:559-65. 2009
    ..Semen quality may therefore be a fundamental biomarker of overall male health...
  60. ncbi Do reproductive hormones explain the association between body mass index and semen quality?
    Dan Dan Qin
    School of Public Health, Fudan University, Shanghai 200433, China
    Asian J Androl 9:827-34. 2007
    ..To examine whether reproductive hormones play a role in the association between body mass index (BMI) and semen quality...
  61. pmc The healthy men study: an evaluation of exposure to disinfection by-products in tap water and sperm quality
    Thomas J Luben
    Department of Epidemiology, University of North Carolina School of Public Health, Chapel Hill, NC, USA
    Environ Health Perspect 115:1169-76. 2007
    ..In this study we assessed DBP exposure and testicular toxicity, as evidenced by altered semen quality...
  62. ncbi Inhibin-B levels in healthy young adult men and prepubertal boys: is obesity the cause for the contemporary decline in sperm count because of fewer Sertoli cells?
    Stephen J Winters
    Department of Medicine, University of Louisville, Louisville, Kentucky 40202, USA
    J Androl 27:560-4. 2006
    ..is thought to support a finite number of germ cells, fewer Sertoli cells in obesity may predispose to a lower sperm count in adulthood...
  63. ncbi Decreased sperm count and sexual behavior in mosquitofish exposed to water from a pesticide-contaminated lake
    Gunnar Toft
    Institute of Biological Sciences, University of Aarhus, Building 135, DK 8000 Aarhus C, Denmark
    Ecotoxicol Environ Saf 60:15-20. 2005
    ..A lower sperm count and disrupted sexual behavior were found in fish exposed for 1 month to water from Lake Apopka, compared to ..
  64. ncbi Determination of some enzymes and macro- and microelements in stallion seminal plasma and their correlations to semen quality
    Sandra Pesch
    Clinic for Obstetrics, Gynecology and Andrology of Large and Small Animals, Justus Liebig University, Giessen, Frankfurter Str 106, 35392 Giessen, Germany
    Theriogenology 66:307-13. 2006
    ..In our study, LDH seems to be the most predictive enzyme for semen quality. This is the first report about GGT, AcP and LDH activities as well as iron in equine seminal plasma...
  65. ncbi Paternity and testicular function among testicular cancer survivors treated with two to four cycles of cisplatin-based chemotherapy
    Marianne Brydøy
    Department of Oncology, Haukeland University Hospital, Bergen, Norway
    Eur Urol 58:134-40. 2010
    ..Preserved fertility is an important issue for testicular cancer (TC) survivors...
  66. pmc Semen quality in relation to xenohormone and dioxin-like serum activity among Inuits and three European populations
    Gunnar Toft
    Department of Occupational Medicine, Aarhus University Hospital, Aarhus, Denmark
    Environ Health Perspect 115:15-20. 2007
    ..Semen quality in humans may be influenced by exposure to endocrine-disrupting compounds...
  67. ncbi Relationship between seminal plasma lactoferrin and gonadal function in horses
    Motohiro Kikuchi
    Laboratory of Theriogenology, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada, Aomori, Japan
    J Vet Med Sci 65:1273-4. 2003
    ..5938, P<0.001) and with the total sperm number (r=0.6959, P<0.001), respectively. There was no correlation between seminal plasma Lf and sperm motility. These results suggest that seminal plasma Lf reflects gonadal function...
  68. pmc Fertility in four regions spanning large contrasts in serum levels of widespread persistent organochlorines: a cross-sectional study
    Gunnar Toft
    Department of Occupational Medicine, Aarhus University Hospital, Noerrebrogade 44, Build, 2C, DK 8000 Aarhus C, Denmark
    Environ Health 4:26. 2005
    ..Persistent organochlorine pollutants (POPs) may interfere with reproductive function but direct evidence in humans is very limited...
  69. ncbi Hong Kong male subfertility links to mercury in human hair and fish
    M D Dickman
    Ecology and Biodiversity Department, University of Hong Kong, Hong Kong
    Sci Total Environ 214:165-74. 1998
    ..Hair samples collected from 16 vegetarians living in Hong Kong (vegans that had consumed no fish, shellfish or meat for at least the last 5 years) had very low levels of mercury. Their mean hair mercury concentration was only 0.38 ppm...
  70. ncbi Effects of methyl parathion (o,o-dimethyl o-4-nitrophenyl phosphorothioate) on rat sperm morphology and sperm count, but not fertility, are associated with decreased ascorbic acid level in the testis
    K Narayana
    Department of Anatomy, Faculty of Medicine, HSC, Kuwait University, P O Box No 24923, Safat 13110, Kuwait
    Mutat Res 588:28-34. 2005
    ..75 or 1.5 mg/kg (experiment 3) for 25 days (i.p.) everyday at intervals of 24 h. The epididymal sperm count, sperm abnormalities and testicular ascorbic acid levels (by 2,4-dinitrophenyl hydrazine method) were estimated ..
  71. ncbi Biophysical and biochemical characteristics of bactrian camel semen collected by artificial vagina
    S Mosaferi
    Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
    Theriogenology 63:92-101. 2005
    ..4 +/- 2.1 and 101.6 +/- 5.5mg/dl, respectively. The concentrations of calcium, phosphorus and chloride were 8.2 +/- 0.1, 2.9 +/- 1.7 mg/dl and 97.9 +/- 2.9 mEq./l, respectively...
  72. pmc Sperm count and chromatin structure in men exposed to inorganic lead: lowest adverse effect levels
    J P Bonde
    Department of Occupational Medicine, University Hospital of Aarhus, Denmark
    Occup Environ Med 59:234-42. 2002
    ..To obtain knowledge on male reproductive toxicity of inorganic lead at current European exposure levels and to establish lowest adverse effect levels, if any...
  73. pmc Geographic differences in semen quality of fertile U.S. males
    Shanna H Swan
    Department of Family and Community Medicine, University of Missouri Columbia School of Medicine, Columbia, Missouri 65212, USA
    Environ Health Perspect 111:414-20. 2003
    ..These data suggest that sperm concentration and motility may be reduced in semirural and agricultural areas relative to more urban and less agriculturally exposed areas...
  74. ncbi The chromosomal risk in sperm from heterozygous Robertsonian translocation carriers is related to the sperm count and the translocation type
    Fatma Ferfouri
    Department of Reproductive Biology, Cytogenetics, Gynecology, and Obstetrics, Poissy, France
    Fertil Steril 96:1337-43. 2011
    To study the chromosomal risk in sperm from Robertsonian translocation (RobT) carriers as a function of the sperm count and translocation type.
  75. ncbi Impaired spermatogenesis in men with congenital absence of the vas deferens
    M V Meng
    Department of Urology, University of California San Francisco School of Medicine, California 94143-0738, USA
    Hum Reprod 16:529-33. 2001
    ..In addition, genetic counselling should be offered and testing for genetic lesions, including cystic fibrosis gene mutations and/or variants, Y chromosome microdeletions, and karyotype abnormalities, should be considered...
  76. ncbi Episodic air pollution is associated with increased DNA fragmentation in human sperm without other changes in semen quality
    Jiri Rubes
    Department of Genetics and Reproduction, Veterinary Research Institute, Brno, Czech Republic
    Hum Reprod 20:2776-83. 2005
    ....
  77. ncbi Statistical modelling reveals demography and time are the main contributing factors in global sperm count changes between 1938 and 1996
    G Bahadur
    UCLMS, Department of Obstetrics and Gynaecology, London, UK
    Hum Reprod 11:2635-9. 1996
    Declining sperm count reports have caused enormous concern to both the scientific community and to society...
  78. ncbi Improvement of penile erection, sperm count and seminal fructose levels in vivo and nitric oxide release in vitro by ayurvedic herbs
    M Thakur
    Centre for Phytochemistry and Pharmacology, Southern Cross University, Lismore, NSW, Australia
    Andrologia 43:273-7. 2011
    In the present study, the effect of four Vajikaran Rasayana herbs on penile erection, sperm count, seminal fructose content in vivo and nitric oxide (NO) release in vitro was assessed...
  79. ncbi Transmission electron microscopy, immunocytochemical and fluorescence in situ hybridisation studies in a case of 100% necrozoospermia: case report
    E Moretti
    Department of Surgery, Biology Section, University of Siena, Siena, Italy
    Andrologia 38:233-8. 2006
    ..FISH sperm analysis highlighted an altered meiotic segregation. After recovery from infection, 100% necrozoospermia persisted and chromosomal sperm aneuploidies were still present...
  80. ncbi Semen quality and age-specific changes: a study between two decades on 3,729 male partners of couples with normal sperm count and attending an andrology laboratory for infertility-related problems in an Indian city
    Dyutiman Mukhopadhyay
    Department of Zoology, University of Calcutta, Calcutta, India
    Fertil Steril 93:2247-54. 2010
    ..To compare the semen quality and age-specific changes in men between the 1980s and 2000s...
  81. ncbi Effect of divergent selection for testosterone production on testicular morphology and daily sperm production in boars
    S Walker
    Department of Animal Science, North Carolina State University, Raleigh 27695 7621, USA
    J Anim Sci 82:2259-63. 2004
    ..However, daily sperm production per gram of testes was unchanged. Based on the results of this study, selection for testosterone production is not recommended as a method of increasing sperm production in pigs...
  82. ncbi Exposure to perfluorinated compounds and human semen quality in Arctic and European populations
    G Toft
    Department of Occupational Medicine, Danish Ramazzini Center, Aarhus University Hospital, Norrebrogade 44, Building 2C, Aarhus C 8000, Denmark
    Hum Reprod 27:2532-40. 2012
    ..Perfluorinated compounds (PFCs) have been suspected to adversely affect human reproductive health. The aim of this study was to investigate the associations between PFC exposure and male semen quality...
  83. ncbi Prenatal testosterone excess reduces sperm count and motility
    Sergio E Recabarren
    Laboratory of Animal Physiology and Endocrinology, Faculty of Veterinary Sciences, University of Concepcion, Casilla 537, Chillan, Chile
    Endocrinology 149:6444-8. 2008
    ..05) in body weight, scrotal circumference, and sperm count compared with control males. Mean straight line velocity of sperms was also lower in T-males (P < 0.05)...
  84. ncbi Relationship between semen quality and tobacco chewing in men undergoing infertility evaluation
    Tamer M Said
    Center for Advanced Research in Human Reproduction, Infertility, and Sexual Function, Glickman Urological Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Fertil Steril 84:649-53. 2005
    ..The objective of our study was to assess the relationship between tobacco chewing in these Indian men--who were part of an infertile couple--and their sperm characteristics...
  85. ncbi Influence of the abstinence period on human sperm quality
    Christopher De Jonge
    Reproductive Medicine Center, University of Minnesota, Minneapolis, Minnesota, USA
    Fertil Steril 82:57-65. 2004
    ..To determine the influence of ejaculatory abstinence on within-subject semen parameters and DNA fragmentation...
  86. ncbi Numerical dose-compensated in vitro fertilization inseminations yield high fertilization and pregnancy rates
    S Benoff
    Department of Obstetrics and Gynecology, North Shore University Hospital New York University School of Medicne, Manhasset 11030, USA
    Fertil Steril 71:1019-28. 1999
    ..To evaluate in cases with morphologically abnormal sperm whether fertilization and pregnancy rates are increased by normalizing the number of sperm inseminated and whether biomarkers can identify cases of reduced or failed fertilization...
  87. ncbi The effect of male body mass index on sperm parameters
    Leila Sekhavat
    Department of Obstetrics and Gynecology, Shahid Sedughi Hospital, Shahid Sedughi University of Medical Sciences and Health Services, Yazd, Iran
    Aging Male 13:155-8. 2010
    ..Total sperm count and sperm motility in overweight and obese men were significantly lower than men with normal BMI too...
  88. ncbi Estimation of genetic parameters of semen characteristics and reproductive traits in AI boars
    J Smital
    Research Institute of Animal Production, P O Box 1, CZ 10401 Prague 10 Uhríneves, Czech Republic
    Anim Reprod Sci 86:119-30. 2005
    ..42, number of insemination doses 0.40, number of piglets born alive 0.08, total number of piglets born 0.05 and conception rate 0.29. Heritabilities and genetic correlations were estimated on average values for each boar...
  89. ncbi Bull spermatozoa under mercury stress
    M Arabi
    Andrology Laboratory, Department of Biology, Shahrekord University, Shahrekord, Iran
    Reprod Domest Anim 40:454-9. 2005
    ..Hence, considering the widespread use of mercury and its compounds, these metals should be regarded with more concern...
  90. ncbi Estrogen receptor alpha promoter polymorphism: stronger estrogen action is coupled with lower sperm count
    Elena Guarducci
    Department of Clinical Physiopathology, Andrology Unit, University of Florence, Florence, Italy
    Hum Reprod 21:994-1001. 2006
    ....
  91. ncbi Caffeine intake and semen quality in a population of 2,554 young Danish men
    Tina Kold Jensen
    University Department of Growth and Reproduction, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark
    Am J Epidemiol 171:883-91. 2010
    ..bottles/week) and/or caffeine (>800 mg/day) intake was associated with reduced sperm concentration and total sperm count, although only significant for cola...
  92. pmc A comparison of conventional and computer-assisted semen analysis (CRISMAS software) using samples from 166 young Danish men
    Anne Vested
    Danish Ramazzini Center, Department of Occupational Medicine, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    Asian J Androl 13:453-8. 2011
    ..This needs to be accounted for in clinics using this software and in studies of determinants of these semen characteristics...
  93. ncbi Microsurgical varicocelectomy in the era of assisted reproductive technology: influence of initial semen quality on pregnancy rates
    K M Kamal
    Division of Urology, Department of Surgery, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    Fertil Steril 75:1013-6. 2001
    ..The initial sperm concentration is predictive of unassisted pregnancy outcome in this population...
  94. ncbi Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent
    Kenneth I Aston
    Andrology and IVF Laboratories, University of Utah School of Medicine, Salt Lake City, UT, USA
    Hum Reprod 25:1383-97. 2010
    ..This is an expanded follow-up study of the SNPs identified by the GWAS as well as other SNPs from previously published gene re-sequencing studies...
  95. ncbi Effect of lifestyle exposures on sperm aneuploidy
    W A Robbins
    UCLA Center for Occupational and Environmental Health, Los Angeles, CA 90095 6919, USA
    Cytogenet Genome Res 111:371-7. 2005
    ..001). In addition, new data on the effect of alcohol intake on sperm chromosome number are presented showing a rate ratio of 1.38 (95% CI 1.2, 1.6) for XY frequency in sperm of alcohol drinkers compared to nondrinkers...
  96. ncbi Contamination of rice by etofenprox, diethyl phthalate and alkylphenols: effects on first delivery and sperm count in mice
    Kunioki Hayashi
    Department of Biochemical Science and Technology, Faculty of Agriculture, Kagoshima University
    J Toxicol Sci 35:49-55. 2010
    ..were administered to mice at the levels detected in rice, and we subsequently observed that first delivery and sperm count of the animals were significantly impaired...
  97. ncbi Cadmium level in seminal plasma may affect the pregnancy rate for patients undergoing infertility evaluation and treatment
    Hsien Ming Wu
    Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Chang Gung University, School of Medicine, Taoyuan, Taiwan, ROC
    Reprod Toxicol 25:481-4. 2008
    ..Simple linear regression analysis revealed an association between semen cadmium concentration NS sperm count (r=-0.150, P=0.0416) in nonsmoking subjects (n=184)...
  98. ncbi Improvement of semen quality by nocturnal scrotal cooling and moderate behavioural change to reduce genital heat stress in men with oligoasthenoteratozoospermia
    A Jung
    Center of Dermatology and Andrology, Justus Liebig University Giessen, D 35392 Giessen, Germany
    Reproduction 121:595-603. 2001
    ..This study shows the importance of genital heat stress as a cofactor in fertility impairment in men and indicates nocturnal scrotal cooling as a therapeutic option...
  99. ncbi Testosterone secretion and pharmacological spermatozoal recovery in the cane toad (Bufo marinus)
    E Iimori
    School of Animal Studies, The University of Queensland, Gatton, Australia
    Anim Reprod Sci 90:163-73. 2005
    ..The hCG protocols developed in this study will have application in studies on the reproductive biology of rare and endangered male anurans...
  100. ncbi New evidence of the influence of exogenous and endogenous factors on sperm count in man
    Wai Yee Wong
    Department of Obstetrics and Gynaecology, University Medical Centre, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Eur J Obstet Gynecol Reprod Biol 110:49-54. 2003
    To examine the association between individual exposures due to occupation, environment and lifestyle on sperm count, we conducted a case-control study among 92 fertile and 73 sub-fertile Caucasian males.
  101. ncbi Determination of the rate of true fertility in duck breeds by the combination of two in vitro methods
    Krisztina Liptói
    Institute for Small Animal Research, H 2100 Godollo, PO Box 417, Hungary
    Acta Vet Hung 52:227-33. 2004
    ..Examination of the relationship between OPVL sperm count and fertility seems to be an adequate tool for checking the effectiveness of insemination programmes and the ..

Research Grants68

  1. New Mouse Mutation Exhibiting Failed Fertilization
    Mary Ann Handel; Fiscal Year: 2006
    ..Affected males are normal with respect to many parameters (body weight, sexual behavior, sperm count and morphology). The phenotype of the ferf1 mutation is breeding failure...
  2. Catenins: A role in spertmatogenesis and sperm maturation
    MANJEET KUMAR RAO; Fiscal Year: 2010
    ..only results in spermatid sloughing (indicating an impaired apical ES), but also causes significantly reduced sperm count and increased germ cell apoptosis...
  3. Regulation and Function of the Rhox5 Homeobox Gene
    MILES FROME WILKINSON; Fiscal Year: 2013
    ..Loss of Rhox5 in mice loss causes increased male germ-cell apoptosis, reduced sperm count, and reduced sperm motility...
  4. REPRODUCTIVE ASSESSMENTS BY CONTINUOIUS BREEDING (RACB)
    Rochelle W Tyl; Fiscal Year: 2009
    ..by Continuous Breeding (RACB);multigenerational reproductive evaluation;Computer Assisted Semen Analyis (CASA);sperm count and motility;vaginal cytology;estrous cyclicity;endocrine disrupting chemicals;antiretroviral agents;..
  5. REPRODUCTIVE ASSESSMENTS BY CONTINUOIUS BREEDING (RACB)
    Rochelle Tyl; Fiscal Year: 2013
    ..by Continuous Breeding (RACB);multigenerational reproductive evaluation;Computer Assisted Semen Analyis (CASA);sperm count and motility;vaginal cytology;estrous cyclicity;endocrine disrupting chemicals;antiretroviral agents;..
  6. Aging and Meiosis in the Nematode Germline
    Judith L Yanowitz; Fiscal Year: 2012
    ..this leads to a significant increase (>15-fold) in aneuploid oocytes by age 40, and in males, a decrease in sperm count. Despite the clinical importance of research in this field, little is known about the underlying molecular ..
  7. H2-Gamendazole analogues as reversible non-hormonal male contraceptive agents
    Joseph S Tash; Fiscal Year: 2013
    ..studies in non-human primates showed completely reversible declines in spermatid count and semen sperm count with no adverse side effects...
  8. Estrogen Free Polymer Formulations for Food Packaging and Baby Products
    STUART YANIGER; Fiscal Year: 2010
    ..EDCs having EA and/or AnA cause various disorders such as uterine dysfunction or reduced sperm count and abnormal brain maturation leading to pathologies such as learning disabilities, disorders of attention, ..
  9. Collaborative Cross: A system genetics approach to the study of male infertility
    Fernando Pardo-Manuel de Villena; Fiscal Year: 2013
    ..phenotypic variation for major male reproductive traits including abnormal testis histology, testis weight, sperm count, sperm motility and infertility;and 3) provide independent validation of the infertility loci mapped in the ..
  10. ASSESSMENT OF GENETIC DAMAGE INDUCED BY CHEMOTHERAPY
    JAN LIANG; Fiscal Year: 1992
    ..Human studies will involve determinations of sperm count, sperm motility, sperm morphology and chromosomal constitutions in semen samples of patients that have been ..
  11. SEMEN AS A BIOMARKER OF EFFECT AMONG LEAD EXPOSED MEN
    Harvey Checkoway; Fiscal Year: 1993
    ..Semen quality will be determined by traditional semen quality assays (sperm count, morphology and motility) and newly developed flow cytometric techniques (sperm chromatin structure assay (SCSA)..
  12. System Genetics of Male Infertility in the Collaborative Cross
    DAVID LAWRENCE AYLOR; Fiscal Year: 2011
    ..understand the biology and genetics of male infertility and its associated reproductive parameters such as sperm count and testis structure. This project is also valuable to develop new methods that apply to the CC population...
  13. Molecular Mechanisms of Testis Development
    ANDREA CUPP; Fiscal Year: 2005
    ..approximately 40-60% of the infertility problems are attributed to male-related factors that include: low sperm count, abnormal spermatogenesis, and reduced androgen production...
  14. Regulation of spermatogonial stem cells by vitamin A
    Derek McLean; Fiscal Year: 2007
    ..50% of the infertility problems are fully or partially attributed to male-related factors which include: low sperm count, abnormal spermatogenesis, and reduced androgen production...
  15. Impact of Endocrine Disrupter on Primate Spermatogenesis
    Suresh Ramaswamy; Fiscal Year: 2003
    ..is that EDs may account for the development of male reproductive disorders in boys and a significant decline in sperm count in men reported to have occurred during the past few decades...
  16. Oral Androgen Administration and Function in Man
    JOHN AMORY; Fiscal Year: 2008
    ..Matsumoto M.D., Director, Clinical Research Unit VA-Puget Sound and Professor of Medicine, University of Washington School of Medicine will co-mentor this award. [unreadable] [unreadable]..
  17. Mechanisms of Growth Factor-Estrogen Receptor Crosstalk
    Stephen Safe; Fiscal Year: 2006
    ..abstract_text> ..
  18. Coactivation of Estrogen Receptor alpha/Sp1
    Stephen Safe; Fiscal Year: 2006
    ..abstract_text> ..
  19. 2,3,7,8,--TCDD Effects on the Estrogenic Responses
    Stephen Safe; Fiscal Year: 2006
    ..The proposed Aims will address important mechanistic considerations on IDRE-independent inhibitory AhR-ERa crosstalk and pathways critical for inhibition of mammary tumor growth by SAhRMs. ..
  20. Maternal Phthalate Exposure and Infertility, Fetal Loss
    Russ Hauser; Fiscal Year: 2007
    ..Since occupational and environmental exposure to phthalates is widespread, detecting even small adverse effects will have large public health significance. ..
  21. Colon Cancer Inhibition by a Class of PPARgamma Agonists
    Stephen Safe; Fiscal Year: 2009
    ..The proposed studies will provide mechanistic insights on PPARy-dependent inhibition of colon cancer and identify compounds for future clinical studies. ..
  22. TOXICOLOGY OF ENVIRONMENT CONTAMINANTS
    Stephen Safe; Fiscal Year: 2007
    ..The proposed training program will continue to provide trainees with a challenging academic and research environment that will prepare them for future careers in academic, industry and government. ..
  23. ESTROGEN INDUCED RESPONSES VIA ER/SPL COMPLEXES
    Stephen Safe; Fiscal Year: 2002
    ..These results will ultimately facilitate design of chemotherapeutic approaches which target specific genes. ..
  24. ALKYL PCDFS--INHIBITION OF MAMMARY CANCER
    Stephen Safe; Fiscal Year: 2001
    ..Thus the proposed studies will define a new mechanism-based class of antiestrogens that can be used alone or in combination with tamoxifen for treatment of breast and endometrial cancer. ..
  25. Maternal Pesticide Exposure and Pregnancy Outcomes
    Russ Hauser; Fiscal Year: 2009
    ..Since the etiology of infertility and early pregnancy loss remains largely unexplained, the identification of potential environmental risk factors will have large public health significance. ..
  26. Inhibition of Pancreatic Cancer by New PPARgamma Agonis*
    Stephen Safe; Fiscal Year: 2008
    ..PPAR? -active C-substituted DIMs that inhibit pancreatic cancer cell growth in vitro and in vivo, and these will serve as lead compounds for development of new drugs for clinical treatment of this devastating disease ..
  27. Harbor-UCLA Initiative for Minority Student Development
    Christina Wang; Fiscal Year: 2005
    ....
  28. Annual SMRU Traveling Scholars Conference
    Susan Benoff; Fiscal Year: 2006
    ..Without this exposure, many of them would have likely pursued different career paths. [unreadable] [unreadable] [unreadable] [unreadable]..
  29. Environmental Endocrine Disrupters 2008 Gordon Research Conference
    Shanna Swan; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  30. Annual SMRU Traveling Scholar Conference
    Susan Benoff; Fiscal Year: 2005
    ..Without this exposure, many of them would have likely pursued different career paths. ..
  31. Vanadocenes as a New Class of Spermicidal Drugs
    OSMOND D CRUZ; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  32. Stampidine: A Novel Broad-Spectrum Anti-HIV Microbicide
    OSMOND D CRUZ; Fiscal Year: 2005
    ..Specific Aims 1 and 2 may provide the foundation for the clinical development of STAMP in Phase II studies as a safe, effective broad-spectrum anti-HIV microbicide without conception-inhibiting functions. ..
  33. NUCLEOPROTEINS IN MAMMALIAN SPERMATOGENESIS
    Marvin Meistrich; Fiscal Year: 2006
    ..Thus they provide a well-defined model system for study of human infertility. ..
  34. NOVEL CONTRACEPTIVES WITH ANTI-HIV ACTIVITY
    OSMOND D CRUZ; Fiscal Year: 2001
    ..The preclinical data on in vivo efficacies of WHI-05 and WHI-07 will be essential to further explore the utility of these novel drugs for clinical studies in human patients. ..
  35. US STUDY OF SEMEN QUALITY IN PARTNERS OF PREGNANT WOMEN
    Shanna Swan; Fiscal Year: 2001
    ....
  36. FLP-102: Rationally Engineered Antiviral Protein
    OSMOND D CRUZ; Fiscal Year: 2003
    ..The preclinical data on FLP-102 will be essential to further explore the utility of this novel recombinant PAP mutant for Phase II. ..
  37. PHI 346: A Novel Dual-Function Microbicide
    OSMOND D CRUZ; Fiscal Year: 2003
    ..Following successful completion of the Phase I in vivo efficacy studies, gel formulation of PHI-346 will be further explored as a vaginal dual-function microbicide in Phase II. ..
  38. METVAN: A Novel Anticancer Agent
    OSMOND D CRUZ; Fiscal Year: 2003
    ..The knowledge gained from these studies described under Specific Aims 1-2 is expected to facilitate the design of innovative treatment regimens employing METVAN for metastatic breast cancer and brain tumor patients. ..
  39. PHI-443: Novel Non-Spermicidal Anti-HIV Microbicide
    OSMOND D CRUZ; Fiscal Year: 2003
    ..Specific Aims 1 and 2 may provide the foundation for the clinical development of PHI-443 in Phase II studies as a safe, effective broad-spectrum anti-HIV microbicide without conception-inhibiting functions. ..
  40. Prostate Cancer Development & Growth
    Christina Wang; Fiscal Year: 2004
    ..The results will provide the important missing link between diet fat and CaP growth and development. ..
  41. INCREASED TESTICULAR CD2+ & INFERTILITY WITH VARICOCELE
    Susan Benoff; Fiscal Year: 2004
    ..Controls will include fertile donors and fertile men with varicocele. ..
  42. Phase II SBIR: WHI-07: A Novel Dual-Function Microbicide
    OSMOND D CRUZ; Fiscal Year: 2005
    ....
  43. Male Reproductive Effects from Exposure to Boron
    Wendie Robbins; Fiscal Year: 2005
    ..Describe the relationship between boron exposure and direct measures of toxicity on male reproduction: total sperm count, sperm density, viability, motility, morphology, and sperm X:Y chromosome ratios sperm chromatin integrity ..
  44. HUMAN SPERM ZONA ACCEPTOR: ENVIRONMENTAL EFFECTS
    Susan Benoff; Fiscal Year: 2005
    ..Outcome is test of hypothesis, and possible mechanism explaining infertility associated with low sperm counts or idiopathic male infertility, tools for diagnosis, and hope for treatment. ..
  45. Epidemiologic Evaluation of Perfluorooctyl Compounds
    James Raymer; Fiscal Year: 2003
    ..If the exposure effect is limited to a sensitive subset of the general population, our study is more likely to detect an association compared to studies that sample on PFOA/PFOS exposure status in an occupational setting. ..
  46. REGULATION OF APOB SECRETION IN INBRED MOUSE STRAINS
    Li Shin Huang; Fiscal Year: 2009
    ..It will also be a potential target for drug discovery and pharmacological intervention in hyperlipidemic patients in the general population. ..
  47. Development of A Sperm Morphology Standard
    SUSAN ROTHMANN; Fiscal Year: 2003
    ..The Standard would be available in print and CD and as an lnternet on-line subscription service for internationally accessible laboratory training and reference. ..
  48. Assessing Reproductive Senescence in Captive Gorillas
    Susan Margulis; Fiscal Year: 2003
    ..Given the current state of the captive gorilla population (roughly 30% of females are considered to be geriatric), this research is timely. ..
  49. International Congress of Neuroendocrinology (ICN 2006)
    TONY PLANT; Fiscal Year: 2006
    ..Because neuroendocrine systems impact upon every aspect of human physiology and behavior, the congress will be directly relevant to better understanding human pathophysiology and psychiatric disease. ..
  50. PROTEIN PHOSPHATASES AND OOCYTE MEIOSIS
    Gary Smith; Fiscal Year: 2002
    ..These studies will provide novel information concerning control of oocyte maturation and spindle formation that may subsequently influence the developmental competency of resulting embryos. ..
  51. OCCUPATIONAL ASTHMA ASOCIATED WITH SEAFOOD PROCESSING
    Thomas Robins; Fiscal Year: 2001
    ..abstract_text> ..
  52. Insulin and Oocyte Chromatin Segregation
    Gary Smith; Fiscal Year: 2009
    ..abstract_text> ..
  53. Modulation of Insulin Action by Testosterone in Men
    Nelly Pitteloud; Fiscal Year: 2010
    ..Therefore, if low T levels are shown to play a role in the pathogenesis of insulin resistance, T may well represent an important therapeutic modality for both preventing and treating the metabolic syndrome and type 2 diabetes in men. ..
  54. POSTDOCTORAL TRAINING IN REPRODUCTIVE PHYSIOLGOY
    TONY PLANT; Fiscal Year: 2005
    ..The Program?s faculty are also members or affiliates of the U54 Center for Research in Reproductive Physiology and, therefore, training will be subserved by the Center?s research. ..
  55. ASI-Spectral Karyotyping (SKY) System
    Muriel Davisson; Fiscal Year: 2005
    ....
  56. Optimizing Testis Transplantation to Study RET Signaling
    Cathy Naughton; Fiscal Year: 2005
    ..Determining how Ret affects testicular function will add to our understanding of human male infertility and may provide an avenue for new treatment strategies for infertile men with nonobstructive azoospermia. ..
  57. EXTRAMURAL RESEARCH FACILITIES IMPROVEMENT PROGRAM
    David Guzick; Fiscal Year: 2003
    ..Since much of the current space will continue to house vision science, this C06 award will create a substantial net increase in vision-research facilities and capabilities. ..
  58. FACTORS AFFECTING SPERM FERTILITY
    Gabor Huszar; Fiscal Year: 2004
    ..non-bound cells; and Aim #4 - extension of the above to testicular biopsies and analysis of spherical spermatids. ..
  59. Mechanisms of Female Urinary Incontinence in Diabetes
    Margot Damaser; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  60. Exposure to Bisphenol A & Reproductive Effect in Humans
    De Kun Li; Fiscal Year: 2007
    ..The proposed study will evaluate the reproductive effects of BPA in settings where there have been high levels of exposure. The study will also investigate effects in multiple human generations. ..
  61. Gene Environment Interaction in Head and Neck Cancer
    Andrew Olshan; Fiscal Year: 2005
    ..The proposed study should contribute knowledge on gene-environment interactions for cancer of the head and neck, but also for other tobacco- and alcohol-related cancers and possibly cancers of unknown etiology. ..
  62. Prenatal NSAID Use and Miscarriage
    De Kun Li; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  63. MECHANISMS OF INCONTINENCE FOLLOWING VAGINAL DISTENSION
    Margot S Damaser; Fiscal Year: 2010
    ....
  64. CASE CONTROL STUDY OF RISK FACTORS FOR WILMS TUMOR
    Andrew Olshan; Fiscal Year: 2002
    ..This study will provide important new advances in our understanding of Wilms tumor given the study size, quality of exposure assessment, and incorporation of clinical and biological markers of etiologic heterogeneity. ..
  65. Prenatal MF Exposure & Miscarriage Risk Among Women
    De Kun Li; Fiscal Year: 2009
    ..The findings from the proposed study will provide much needed confirmation of the recently reported results and advance our understanding of a MF health effect. ..
  66. INDUCED ABORTION AND BREAST CANCER RISK
    De Kun Li; Fiscal Year: 2001
    ....