serologic tests

Summary

Summary: Diagnostic procedures involving immunoglobulin reactions.

Top Publications

  1. ncbi Facing the crisis: improving the diagnosis of tuberculosis in the HIV era
    Mark D Perkins
    Foundation for Innovative New Diagnostics, Geneva, Switzerland
    J Infect Dis 196:S15-27. 2007
  2. ncbi Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition
    Ivor D Hill
    North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, Flourtown, PA 19031, USA
    J Pediatr Gastroenterol Nutr 40:1-19. 2005
  3. pmc Diagnosis of visceral leishmaniasis
    Pankaj Srivastava
    Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
    Trans R Soc Trop Med Hyg 105:1-6. 2011
  4. ncbi Novel Treponema pallidum serologic tests: a paradigm shift in syphilis screening for the 21st century
    Arlene C Sena
    Department of Medicine, University of North Carolina at Chapel Hill, NC 27599, USA
    Clin Infect Dis 51:700-8. 2010
  5. ncbi The diagnostic accuracy of serologic tests for celiac disease: a systematic review
    Alaa Rostom
    Gastrointestinal Clinical Research Unit, University of Ottawa, Ottawa, Canada
    Gastroenterology 128:S38-46. 2005
  6. pmc Sensitivity and specificity of serologic assays for detection of human infection with 2009 pandemic H1N1 virus in U.S. populations
    Vic Veguilla
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, National Center for Immunization and Respiratory Diseases, Centers for Disease Control andPrevention, 2 Atlanta, Georgia 30333, USA
    J Clin Microbiol 49:2210-5. 2011
  7. pmc Performance of purified antigens for serodiagnosis of pulmonary tuberculosis: a meta-analysis
    Karen R Steingart
    Francis J Curry National Tuberculosis Center, University of California, San Francisco, 3180 18th Street, Suite 101, San Francisco, CA 94110 2028, USA
    Clin Vaccine Immunol 16:260-76. 2009
  8. ncbi Acute West Nile virus neuroinvasive infections: cross-reactivity with dengue virus and tick-borne encephalitis virus
    Anna Papa
    Department of Microbiology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
    J Med Virol 83:1861-5. 2011
  9. ncbi West Nile virus: recent trends in diagnosis and vaccine development
    G Dauphin
    AFSSA Alfort, UMR1161 INRA AFSSA ENVA, 23 av Général de Gaulle, 94703 Maisons Alfort Cedex, France
    Vaccine 25:5563-76. 2007
  10. ncbi Chagas disease: recombinant Trypanosoma cruzi antigens for serological diagnosis
    J F da Silveira
    Dept Micro, Imuno e Parasitologia da Escola Paulista de Medicina, UNIFESP, Rua Botucatu 862, CEP 04023-062, , Brazil
    Trends Parasitol 17:286-91. 2001

Detail Information

Publications294 found, 100 shown here

  1. ncbi Facing the crisis: improving the diagnosis of tuberculosis in the HIV era
    Mark D Perkins
    Foundation for Innovative New Diagnostics, Geneva, Switzerland
    J Infect Dis 196:S15-27. 2007
    ..In this article, we will define the need for better TB tests and describe technologies being developed to meet that need...
  2. ncbi Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition
    Ivor D Hill
    North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, Flourtown, PA 19031, USA
    J Pediatr Gastroenterol Nutr 40:1-19. 2005
    ..This document represents the official recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition on the diagnosis and treatment of celiac disease in children and adolescents...
  3. pmc Diagnosis of visceral leishmaniasis
    Pankaj Srivastava
    Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
    Trans R Soc Trop Med Hyg 105:1-6. 2011
    ..A simple, rapid, non invasive, accurate and cost effective marker of active VL, which can be used in field conditions, is necessary to improve diagnosis of VL...
  4. ncbi Novel Treponema pallidum serologic tests: a paradigm shift in syphilis screening for the 21st century
    Arlene C Sena
    Department of Medicine, University of North Carolina at Chapel Hill, NC 27599, USA
    Clin Infect Dis 51:700-8. 2010
    The mainstay of diagnosis for Treponema pallidum infections is based on nontreponemal and treponemal serologic tests. Many new diagnostic methods for syphilis have been developed, using specific treponemal antigens and novel formats, ..
  5. ncbi The diagnostic accuracy of serologic tests for celiac disease: a systematic review
    Alaa Rostom
    Gastrointestinal Clinical Research Unit, University of Ottawa, Ottawa, Canada
    Gastroenterology 128:S38-46. 2005
    Clinicians are increasingly utilizing noninvasive serologic tests for the diagnosis and screening of celiac disease (CD)...
  6. pmc Sensitivity and specificity of serologic assays for detection of human infection with 2009 pandemic H1N1 virus in U.S. populations
    Vic Veguilla
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, National Center for Immunization and Respiratory Diseases, Centers for Disease Control andPrevention, 2 Atlanta, Georgia 30333, USA
    J Clin Microbiol 49:2210-5. 2011
    ..S. populations during the first pandemic waves. These studies provide an approach to optimize timely serological investigations for future pandemics or outbreaks of novel influenza viruses among humans...
  7. pmc Performance of purified antigens for serodiagnosis of pulmonary tuberculosis: a meta-analysis
    Karen R Steingart
    Francis J Curry National Tuberculosis Center, University of California, San Francisco, 3180 18th Street, Suite 101, San Francisco, CA 94110 2028, USA
    Clin Vaccine Immunol 16:260-76. 2009
    ..The use of a case-control design with healthy controls for the majority of studies was a limitation of the review. Efforts are needed to improve the methodological quality of tuberculosis diagnostic studies...
  8. ncbi Acute West Nile virus neuroinvasive infections: cross-reactivity with dengue virus and tick-borne encephalitis virus
    Anna Papa
    Department of Microbiology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
    J Med Virol 83:1861-5. 2011
    ..There is a need for caution when evaluating serologic results of flaviviral infections, while efforts have to be focused on the development of diagnostic assays with increased specificity...
  9. ncbi West Nile virus: recent trends in diagnosis and vaccine development
    G Dauphin
    AFSSA Alfort, UMR1161 INRA AFSSA ENVA, 23 av Général de Gaulle, 94703 Maisons Alfort Cedex, France
    Vaccine 25:5563-76. 2007
    ..Finally, licensed vaccines and candidate vaccines developed in humans, horses and birds will also been described...
  10. ncbi Chagas disease: recombinant Trypanosoma cruzi antigens for serological diagnosis
    J F da Silveira
    Dept Micro, Imuno e Parasitologia da Escola Paulista de Medicina, UNIFESP, Rua Botucatu 862, CEP 04023-062, , Brazil
    Trends Parasitol 17:286-91. 2001
    ..Managers of laboratories and blood banks need to make decisions on a cost-benefit basis whether to include these new-generation tests. Here, we indicate antigens that are likely to prove most useful...
  11. pmc Evaluation of enzyme-linked immunosorbent assays, an immunofluorescent-antibody test, and two rapid tests (immunochromatographic-dipstick and gel tests) for serological diagnosis of symptomatic and asymptomatic Leishmania infections in dogs
    Maik Mettler
    Institute of Parasitology, University of Zurich, Zurich, Switzerland
    J Clin Microbiol 43:5515-9. 2005
    ..Rapid tests like the rK39 dipstick test or the ID-PaGIA are helpful for confirming clinically suspected cases because of their high specificities in symptomatic animals...
  12. pmc Predictors of serological cure and Serofast State after treatment in HIV-negative persons with early syphilis
    Arlene C Sena
    Division of Infectious Diseases, Department of Medicine, University of North Carolina, Chapel Hill, NC, USA
    Clin Infect Dis 53:1092-9. 2011
    ..Syphilis management requires serological monitoring after therapy. We compared factors associated with serological response after treatment of early (ie, primary, secondary, or early latent) syphilis...
  13. ncbi Use of recombinant calreticulin and cercarial transformation fluid (CTF) in the serodiagnosis of Schistosoma mansoni
    Bahaa El Deen Wade El Aswad
    Department of Infection, Immunity and Inflammation, University of Leicester, Leicester LE1 9HN, United Kingdom
    Immunobiology 216:379-85. 2011
    ..CTF was substantially more specific than SEA for diagnosis in the endemic region, and less susceptible than SEA to cross-reacting antibody in the sera of controls with other protozoan and metazoan infections...
  14. pmc Second external quality assurance study for the serological diagnosis of hantaviruses in Europe
    Camille Escadafal
    ZBS 1, Robert Koch Institute, Berlin, Germany
    PLoS Negl Trop Dis 6:e1607. 2012
    ..Uneven performances using the same method is indicating that there is still a need for improving testing conditions and standardizing protocols...
  15. ncbi Use of a nested polymerase chain reaction (N-PCR) to detect Trypanosoma cruzi in blood samples from chronic chagasic patients and patients with doubtful serologies
    Gláucia Elisete Barbosa Marcon
    Departamento de Clinica Medica, Faculdade de Ciências Médicas Universidade Estadual de Campinas, Campinas, Sao Paulo, Brazil
    Diagn Microbiol Infect Dis 43:39-43. 2002
    Chagas disease, caused by Trypanosoma cruzi, is an important endemic illness in Latin America. Serologic tests for T. cruzi detection in blood are sensitive, but their specificity is unsatisfactory...
  16. pmc Improved diagnosis of Strongyloides stercoralis using recombinant antigen-based serologies in a community-wide study in northern Argentina
    Alejandro J Krolewiecki
    Area de Investigaciones Clinicas, Fundacion Huesped, Pje Peluffo 3932, Buenos Aires, Argentina
    Clin Vaccine Immunol 17:1624-30. 2010
    ..NIE-LIPS compares favorably against the current CrAg-ELISA and stool evaluation, providing additional accuracy and ease of performance in the serodiagnosis of S. stercoralis infections irrespective of disease prevalence...
  17. pmc Prospective study of serological conversion as a risk factor for development of leprosy among household contacts
    J T Douglas
    Department of Microbiology, University of Hawaii, Honolulu, HI 96822, USA
    Clin Diagn Lab Immunol 11:897-900. 2004
    ..Seropositive household contacts had a significantly higher risk of developing leprosy (relative hazard adjusted for age and sex [aRH], 7.2), notably multibacillary leprosy (aRH = 24), than seronegative contacts...
  18. pmc Diagnosis and management of human cytomegalovirus infection in the mother, fetus, and newborn infant
    Maria Grazia Revello
    Servizio di Virologia, IRCCS Policlinico San Matteo, 27100 Pavia, Italy
    Clin Microbiol Rev 15:680-715. 2002
    ....
  19. ncbi An integrated microfluidic system for rapid diagnosis of dengue virus infection
    Yu Fang Lee
    Department of Engineering Science, National Cheng Kung University, Tainan 701, Taiwan
    Biosens Bioelectron 25:745-52. 2009
    ..This integrated system may provide a powerful platform for the rapid diagnosis of dengue virus infection and other types of infectious diseases...
  20. pmc Use of a recombinant envelope protein subunit antigen for specific serological diagnosis of West Nile virus infection
    David W C Beasley
    Department of Pathology, UTMB, 301 University Blvd, Galveston, TX 77555 0609, USA
    J Clin Microbiol 42:2759-65. 2004
    ....
  21. ncbi Regions of differences encoded antigens as targets for immunodiagnosis of tuberculosis in humans
    O Parkash
    Department of Immunology, National JALMA Institute for Leprosy and Other Mycobacterial Diseases, Tajganj, Agra, India
    Scand J Immunol 70:345-57. 2009
    ..This article provides an overview of the use of RD antigens in the immunodiagnosis of tuberculosis infection and disease...
  22. pmc Evaluation of widely used diagnostic tests to detect West Nile virus infections in horses previously infected with St. Louis encephalitis virus or dengue virus type 2
    Jeremy P Ledermann
    Centers for Disease Control and Prevention, Division of Vector Borne Infectious Diseases, 3150 Rampart Road, Fort Collins, CO 80521, USA
    Clin Vaccine Immunol 18:580-7. 2011
    ..Of great importance, we demonstrated that timing of sample collection and the need for multiple samples are important, as the infecting etiology could be misdiagnosed if only a single sample is tested...
  23. pmc Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007
    Robert S Lanciotti
    Diagnostic and Reference Laboratory, Arbovirus Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, Colorado 80521, USA
    Emerg Infect Dis 14:1232-9. 2008
    ..In June 2007, an epidemic of fever and rash associated with ZIKV was detected in Yap State, Federated States of Micronesia. We report the genetic and serologic properties of the ZIKV associated with this epidemic...
  24. ncbi Evaluation of new-generation serologic tests for the diagnosis of typhoid fever: data from a community-based surveillance in Calcutta, India
    Shanta Dutta
    National Institute of Cholera and Enteric Diseases, P 33 CIT Road, Scheme XM, Beliaghata, P O Box 177, Calcutta 700010, India
    Diagn Microbiol Infect Dis 56:359-65. 2006
    ..typhoid fever is confirmed by culture of Salmonella enterica serotype Typhi, rapid and simple diagnostic serologic tests would be useful in developing countries...
  25. ncbi International diagnostic accuracy study for the serological detection of chikungunya virus infection
    M Niedrig
    Centre for Biological Safety ZBS 1, Robert Koch Institut, Berlin, Germany
    Clin Microbiol Infect 15:880-4. 2009
    ....
  26. pmc Usefulness of four different Echinococcus granulosus recombinant antigens for serodiagnosis of unilocular hydatid disease (UHD) and postsurgical follow-up of patients treated for UHD
    Ana Hernandez-Gonzalez
    IRNASA, CSIC, Cordel de Merinas, 50, 37008 Salamanca, Spain
    Clin Vaccine Immunol 15:147-53. 2008
    ..4 and 94.2, respectively). In addition, this diagnostic tool proved to be useful for the follow-up of surgically treated UHD patients. The anti-B2t IgG ELISA may find an application in the serodiagnosis of UHD in clinical laboratories...
  27. ncbi Comparative evaluation of parasitology and serological tests in the diagnosis of visceral leishmaniasis in India: a phase III diagnostic accuracy study
    S Sundar
    Infectious Diseases Research Laboratory, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
    Trop Med Int Health 12:284-9. 2007
    ..986). Although DAT-FD and rK-39 strip test were highly sensitive with excellent specificity, the ease of use of the latter makes it most suitable for the diagnosis of VL in the field conditions...
  28. ncbi Serodiagnosis of human bocavirus infection
    Kalle Kantola
    Department of Virology, Haartman Institute, University of Helsinki, Finland
    Clin Infect Dis 46:540-6. 2008
    ..Moreover, nothing is known of HBoV immunity. We examined HBoV-specific systemic B cell responses and assessed their diagnostic use in young children with respiratory disease...
  29. pmc Serology of typhoid fever in an area of endemicity and its relevance to diagnosis
    D House
    Department of Biochemistry, Imperial College of Science, Technology and Medicine, Exhibition Road, South Kensington, London SW7 2AZ, United Kingdom
    J Clin Microbiol 39:1002-7. 2001
    ..007). These tests could be of use for the diagnosis of typhoid fever in patients who have clinical typhoid fever but are culture negative or in regions where bacterial culturing facilities are not available...
  30. ncbi Evaluation of Mycobacterium tuberculosis--specific antibody responses in populations with different levels of exposure from Tanzania, Ethiopia, Brazil, and Denmark
    Soren T Hoff
    Department of Infectious Diseases Immunology, Statens Serum Institute, Copenhagen S, Denmark
    Clin Infect Dis 45:575-82. 2007
    ..A key question remaining is the extent to which the disappointing performance of current tests is associated with a high background prevalence of latent TB...
  31. ncbi Coeliac disease: is it time for mass screening?
    M Luisa Mearin
    Pediatric Gastroenterology, Department of Pediatrics, Leiden University Medical Centre, P O Box 9600, 2300 RC Leiden, The Netherlands
    Best Pract Res Clin Gastroenterol 19:441-52. 2005
    ..The economic costs of screening and treatment versus morbidity prevented have not been calculated...
  32. pmc Evaluation of four commercially available rapid serologic tests for diagnosis of leptospirosis
    Mary D Bajani
    Meningitis and Special Pathogens Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Clin Microbiol 41:803-9. 2003
    ..The ease of use and significantly high sensitivity and specificity of DST and ELISA make these good choices for diagnostic testing...
  33. ncbi Screening for congenital toxoplasmosis: accuracy of immunoglobulin M and immunoglobulin A tests after birth
    Ruth E Gilbert
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, London, UK
    J Med Screen 14:8-13. 2007
    ..To determine the accuracy of postnatal screening for toxoplasma-specific immunoglobulin (Ig) M and IgA...
  34. pmc Serodiagnosis of imported schistosomiasis by a combination of a commercial indirect hemagglutination test with Schistosoma mansoni adult worm antigens and an enzyme-linked immunosorbent assay with S. mansoni egg antigens
    Tom van Gool
    Department of Microbiology, Tropical Medicine and AIDS, Academic Medical Centre, University of Amsterdam, The Netherlands
    J Clin Microbiol 40:3432-7. 2002
    ..The combined use of these two tests enabled the serological diagnosis of schistosomiasis to be achieved with very high degrees of both sensitivity and specificity...
  35. pmc Identification and cloning of immunodominant antigens of Coxiella burnetii
    Guoquan Zhang
    Department of Medical Microbiology and Immunology, Texas A and M University System Health Science Center, College Station, Texas 77843 1114, USA
    Infect Immun 72:844-52. 2004
    ..These results suggest that these proteins may play critical roles in the development of protective immunity and that they are logical candidates for vaccine and serodiagnostic reagents...
  36. ncbi Clinical use of polymerase chain reaction performed on peripheral blood and bone marrow samples for the diagnosis and monitoring of visceral leishmaniasis in HIV-infected and HIV-uninfected patients: a single-center, 8-year experience in Italy and review
    Spinello Antinori
    Dipartimento di Scienze Cliniche L Sacco, Sezione di Malattie Infettive e Tropicali, Universita di Milano, Milan, Italy
    Clin Infect Dis 44:1602-10. 2007
    ..To overcome some of the limitations of conventional microbiologic techniques, polymerase chain reaction (PCR)-based assays are proposed as useful tools for the diagnosis of visceral leishmaniasis...
  37. pmc A systematic review of high quality diagnostic tests for Chagas disease
    Anna M Afonso
    Department of Epidemiology and Biostatistics, University of Georgia, Athens, Georgia, United States of America
    PLoS Negl Trop Dis 6:e1881. 2012
    ..To avoid associated spectrum bias, our analysis was limited to cohort studies...
  38. pmc Antiretroviral therapy is associated with reduced serologic failure rates for syphilis among HIV-infected patients
    Khalil G Ghanem
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Clin Infect Dis 47:258-65. 2008
    ..Our goal was to determine whether the degree of HIV-mediated immunosuppression and the use of highly active antiretroviral therapy impact syphilis serologic responses...
  39. ncbi Development of cathepsin-L cysteine proteinase based Dot-enzyme-linked immunosorbent assay for the diagnosis of Fasciola gigantica infection in buffaloes
    Anju Varghese
    Division of Parasitology, Indian Veterinary Research Institute, Izatnagar 243122, India
    Vet Parasitol 183:382-5. 2012
    ..The present Dot-ELISA diagnostic assay is relevant to the field diagnosis of F. gigantica infection in buffaloes...
  40. pmc Development of epitope-blocking ELISA for universal detection of antibodies to human H5N1 influenza viruses
    Mookkan Prabakaran
    Animal Health Biotechnology, Temasek Life Sciences Laboratory, National University of Singapore, Singapore, Singapore
    PLoS ONE 4:e4566. 2009
    ..Serologic surveillance has potential advantages which have not been realized because rapid and specific serologic tests to detect H5N1 infection are not widely available.
  41. ncbi Serological evaluation of experimentally infected dogs by LicTXNPx-ELISA and amastigote-flow cytometry
    Ricardo Silvestre
    Parasite Disease Group, IBMC Instituto de Biologia Molecular e Celular, Universidade do Porto, Portugal
    Vet Parasitol 158:23-30. 2008
    ..2%. Therefore, our findings showed for the first time the potential of amastigote-flow cytometry regarding their applicability to detect both symptomatic and asymptomatic VL canine infections...
  42. ncbi Evaluation of a multiplex fluorescent microsphere immunoassay for the determination of epstein-barr virus serologic status
    Thomas B Martins
    Associated Regional and University Pathologists ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT 84108, USA
    Am J Clin Pathol 129:34-41. 2008
    ..Advantages of the multiplex assay over traditional methods include multiple results per assay, inclusion of internal controls for each assay, and well-to-well monitoring of assay drift...
  43. ncbi Profiling of rheumatoid arthritis associated autoantibodies
    Karsten Conrad
    Institute of Immunology, Technical University Dresden, Germany
    Autoimmun Rev 9:431-5. 2010
    ..The inclusion of novel RA-associated AAB (RAAB) and use of clinically evaluated multiplex assays may facilitate the use of profiling in diagnostic routine laboratories...
  44. pmc First international diagnostic accuracy study for the serological detection of West Nile virus infection
    Matthias Niedrig
    Centre for Biological Safety ZBS 1, Robert Koch Institut, Nordufer 20, Berlin, Germany
    BMC Infect Dis 7:72. 2007
    ..However, as the degree of proficiency may vary between laboratories, quality control measures for laboratory diagnostics are essential...
  45. pmc Evaluation of six immunoassays for detection of dengue virus-specific immunoglobulin M and G antibodies
    J Groen
    Laboratory for Exotic Viral Infections, WHO Center for Arboviruses and Hemorrhagic Fevers Reference and Research, Institute of Virology, Erasmus Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands
    Clin Diagn Lab Immunol 7:867-71. 2000
    ....
  46. pmc Seroreactivity to and avidity for recombinant antigens in toxoplasmosis
    Klaus Ingmar Pfrepper
    MIKROGEN molekularbiologische Entwicklungs GmbH, Neuried, Germany
    Clin Diagn Lab Immunol 12:977-82. 2005
    ..The data revealed that the recombinant line assay provides valuable information on the actual state of infection, especially during the early infection time points...
  47. pmc Towards a more precise serological diagnosis of human tegumentary leishmaniasis using Leishmania recombinant proteins
    Ana Paula Souza
    Centro de Pesquisas Gonçalo Moniz CPqGM, Fundação Oswaldo Cruz FIOCRUZ, Salvador, Bahia, Brazil
    PLoS ONE 8:e66110. 2013
    ..Exposure to Leishmania induces a humoral immune response that can be used as a marker of parasite exposure...
  48. ncbi A recombinant cysteine proteinase from Leishmania (Leishmania) chagasi suitable for serodiagnosis of American visceral leishmaniasis
    Suzana de Souza Dias
    Department of Microbiology, Immunology and Parasitology, Universidade Federal de Sao Paulo, Escola Paulista de Medicina, Sao Paulo, Brazil
    Am J Trop Med Hyg 72:126-32. 2005
    ..Our findings indicate that rLdccys1 from L. (L.) chagasi constitutes a potential tool for the diagnosis of American VL...
  49. pmc Development of recombinant chimeric antigen expressing immunodominant B epitopes of Leishmania infantum for serodiagnosis of visceral leishmaniasis
    A Boarino
    Dipartimento di Produzioni Animali, Epidemiologia ed Ecologia, Facolta di Medicina Veterinaria, Via Leonardo da Vinci 44, 10095 Grugliasco TO Italy
    Clin Diagn Lab Immunol 12:647-53. 2005
    ..93 to 0.98) was higher than between IFAT and human chimeric ELISA (k = 0.81, 95% confidence interval = 0.76 to 0.87). Results suggest the potential use of this new antigen for routine serodiagnosis of VL in both human and canine hosts...
  50. ncbi Factors determining serologic response to treatment in patients with syphilis
    Julio J González-López
    Division of Infectious Diseases and Dermatology, Department of Medicine, Fundacion Jimenez Diaz, Universidad Autonoma de Madrid, Spain
    Clin Infect Dis 49:1505-11. 2009
    ....
  51. pmc Serological response to treatment of syphilis according to disease stage and HIV status
    Damaris Fröhlich Knaute
    Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, CH 8091 Zurich, Switzerland
    Clin Infect Dis 55:1615-22. 2012
    ..Serology is the mainstay for syphilis diagnosis and treatment monitoring. We investigated serological response to treatment of syphilis according to disease stage and HIV status...
  52. ncbi Prevalence of measles, rubella, mumps, and varicella antibodies among healthcare workers in Japan
    Shuji Hatakeyama
    Department of Infectious Diseases, University of Tokyo Hospital, Hongo, Bunkyo ku, Tokyo, Japan
    Infect Control Hosp Epidemiol 25:591-4. 2004
    ..To evaluate the immune status of healthcare workers (HCWs) against measles, rubella, mumps, and varicella in Japan, and to promote an adequate vaccination program among HCWs...
  53. ncbi Diagnosis of visceral leishmaniasis: developments over the last decade
    Gurumurthy Srividya
    Molecular Biology Laboratory, National Institute of Pathology ICMR, Safdarjung Hospital Campus, New Delhi 110029, India
    Parasitol Res 110:1065-78. 2012
    ..This review summarizes the recent developments in VL diagnostics, drawing attention towards the need for standardization of the diagnostics across the affected regions...
  54. pmc Community acquired pneumonia--a prospective UK study
    P Drummond
    Department of Paediatrics, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, UK
    Arch Dis Child 83:408-12. 2000
    ..There are few data on paediatric community acquired pneumonia (PCAP) in the UK...
  55. ncbi Diagnostic performance of tests based on Trypanosoma cruzi excreted-secreted antigens in an endemic area for Chagas' disease in Bolivia
    Carlos Rodrigo Zarate-Blades
    Centro de Investigacion y Diagnóstico de la Enfermedad de Chagas, CIDECH, Universidad Mayor de San Francisco Xavier, Calle Dalence 243, Sucre, 617 Bolivia
    Diagn Microbiol Infect Dis 57:229-32. 2007
    ..Of the 742 samples, 329 (44.34 %) were positive in the TESA blot assay, which diagnosed 9 Trypanosoma cruzi-infected individuals missed by conventional serologic tests.
  56. pmc Comparison and evaluation of real-time PCR, real-time nucleic acid sequence-based amplification, conventional PCR, and serology for diagnosis of Mycoplasma pneumoniae
    Kate E Templeton
    Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands
    J Clin Microbiol 41:4366-71. 2003
    ..Molecular methods are superior for diagnosis of M. pneumoniae, providing more timely diagnosis. In addition, using real-time methods involves less hands-on time and affords the ability to monitor the reaction in the same tube...
  57. pmc Commercial serological tests for the diagnosis of active pulmonary and extrapulmonary tuberculosis: an updated systematic review and meta-analysis
    Karen R Steingart
    Department of Health Services, University of Washington School of Public Health, Seattle, Washington, United States of America
    PLoS Med 8:e1001062. 2011
    ....
  58. ncbi Quality control assessment for the serological diagnosis of dengue virus infections
    Oliver Donoso Mantke
    Robert Koch Institut, Nordufer 20, 13353 Berlin, Germany
    J Clin Virol 29:105-12. 2004
    ..Improving diagnostics is the most important step in detecting and dealing with these pathogens and quality control measures are, therefore, essential tools...
  59. ncbi Use of serologic tests to predict resistance to feline herpesvirus 1, feline calicivirus, and feline parvovirus infection in cats
    Michael R Lappin
    Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    J Am Vet Med Assoc 220:38-42. 2002
    ....
  60. pmc Serological testing versus other strategies for diagnosis of active tuberculosis in India: a cost-effectiveness analysis
    David W Dowdy
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
    PLoS Med 8:e1001074. 2011
    ..The cost and impact of using serology compared with other diagnostic techniques is unknown...
  61. ncbi Novel opportunities in automated classification of antinuclear antibodies on HEp-2 cells
    Amelia Rigon
    Clinical Medicine and Rheumatology, Campus Bio Medico University of Rome, Italy
    Autoimmun Rev 10:647-52. 2011
    ..Our data represent a first step to validate the use of Computer Aided Diagnosis (CAD), thus offering an opportunity for standardizing and automatizing the detection of ANA by IIF...
  62. ncbi Dot immunogold filtration assay (DIGFA) with multiple native antigens for rapid serodiagnosis of human cystic and alveolar echinococcosis
    Xiaohui Feng
    Xinjiang Hydatid Clinical Research Institute, First Teaching Hospital of Xinjiang Medical University, No 1 Liyushan RD, Urumqi 830000, Xinjiang, China
    Acta Trop 113:114-20. 2010
    ..6% and for AE using Em2 was 97.1%. This simple eye-read rapid test can be used for both clinical diagnostic support, as well as in conjunction with ultrasound for mass screening in endemic CE and AE areas...
  63. ncbi Can the nucleic acid amplification test (NAT) be an alternative to the serologic tests? A prospective study, the results of 18,200 blood donors from the Turkish Red Crescent
    Erdogan Kosan
    Capa, Red Crescent Blood Center, Istanbul, Turkey
    Transfus Apher Sci 43:269-72. 2010
    b>Serologic tests having high sensitivity and specificity are used in order to prevent contamination with infectious agents from blood and blood products for transfusion safety...
  64. ncbi Multiplex assessment of non-organ-specific autoantibodies with a novel microbead-based immunoassay
    Kai Grossmann
    Lausitz University of Applied Sciences, Senftenberg, Germany
    Cytometry A 79:118-25. 2011
    ..Multicolor fluorescence analyses with pattern detection algorithms provide a common platform technique for both the screening of ANA by cell-based IIF and specific antibody assessment by multiplex detection...
  65. ncbi Seroprevalences of feline leukemia virus and feline immunodeficiency virus in cats with abscesses or bite wounds and rate of veterinarian compliance with current guidelines for retrovirus testing
    Carrie E Goldkamp
    Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA
    J Am Vet Med Assoc 232:1152-8. 2008
    ....
  66. ncbi Diagnosis of Strongyloides stercoralis infection
    A A Siddiqui
    Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA
    Clin Infect Dis 33:1040-7. 2001
    ..This review describes the clinical manifestations of strongyloidiasis, as well as various diagnostic tests and treatment strategies...
  67. ncbi Characterisation of recombinant immunoreactive antigens of the scab mite Sarcoptes scabiei
    C Kuhn
    Department of Molecular Parasitology, Institute of Biology, Humboldt University Berlin, Berlin, Germany
    Vet Parasitol 153:329-37. 2008
    ..Three of the proteins contain repetitive sequences which suggests that they might be involved in immune evasion. The application of these antigens in serodiagnosis and the suitability for diagnosis is discussed...
  68. ncbi Genus and species-specific IgG and IgM antibodies for pulmonary tuberculosis
    Tariq Butt
    Department of Microbiology, Armed Forces Institute of Pathology, Rawalpindi
    J Coll Physicians Surg Pak 14:105-7. 2004
    ..To evaluate three different enzyme immunoassays for serological diagnosis of pulmonary tuberculosis and to compare their diagnostic accuracy in different combinations...
  69. ncbi Molecular characterization and serodiagnosis analysis of a novel lysophospholipase from Clonorchis sinensis
    Changling Ma
    Department of Parasitology, Zhongshan School of Medicine, SunYat sen University, Guangzhou, 510080, People s Republic of China
    Parasitol Res 101:419-25. 2007
    ..The results suggested that the recombinant lysophospholipase protein was not a satisfactory candidate for diagnosis of clonorchiasis, although it might be an excretory/secretory protein...
  70. ncbi Evaluation of immunological markers in serum, filter-paper blood spots, and saliva for dengue diagnosis and epidemiological studies
    Angel Balmaseda
    Departamento de Virologia, Centro Nacional de Diagnostico y Referencia, Ministerio de Salud, Apartado Postal 2900, Managua, Nicaragua
    J Clin Virol 43:287-91. 2008
    ..Numerous immunological approaches exist to diagnose dengue or detect dengue virus (DENV) infections...
  71. ncbi Utility of K39 strip test in visceral leishmaniasis (VL) and HIV co-infected patients: an early report from Eastern India
    R P Goswami
    J Assoc Physicians India 55:154-5. 2007
  72. pmc Canine leishmaniosis and its relationship to human visceral leishmaniasis in Eastern Uzbekistan
    Dmitriy A Kovalenko
    Isaev Institute, Samarkand, Uzbekistan
    Parasit Vectors 4:58. 2011
    ..A study on the epidemiology of VL in this area was carried out in 2007-2008 in the villages of Chodak, Oltinkan, Gulistan and Chorkesar located at elevations of 900-1200 above sea level...
  73. pmc Polymerase chain reaction is superior to serology for the diagnosis of acute Mycoplasma pneumoniae infection and reveals a high rate of persistent infection
    Anna C Nilsson
    Department of Clinical Sciences, Malmo, Infectious Disease Research Unit, Lund University, Malmo University Hospital, Sweden
    BMC Microbiol 8:93. 2008
    ..PCR-positive individuals were followed longitudinally to assess the persistence of MP DNA in throat secretions. We also studied carriage of MP among household contacts and school children...
  74. ncbi Immunologic diagnosis of tuberculosis
    M L Gennaro
    Public Health Research Institute, New York, NY 10016, USA
    Clin Infect Dis 30:S243-6. 2000
    ..tuberculosis...
  75. ncbi Cytomegalovirus seropositivity and C-reactive protein have independent and combined predictive value for mortality in patients with angiographically demonstrated coronary artery disease
    J B Muhlestein
    LDS Hospital, University of Utah, Salt Lake City 84143, USA
    Circulation 102:1917-23. 2000
    ....
  76. ncbi Contribution of serological tests and blood culture to the early diagnosis of systemic candidiasis
    H Yera
    Laboratoire de Parasitologie-Mycologie, CHRU, , Lille, France
    Eur J Clin Microbiol Infect Dis 20:864-70. 2001
    ..In this way, more efficient management of nosocomial infections caused by Candida species can be achieved...
  77. ncbi Concomitant or consecutive infection with Coxiella burnetii and tickborne diseases
    J M Rolain
    Unite des Rickettsies, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
    Clin Infect Dis 40:82-8. 2005
    ..In this study, we describe 6 patients with Q fever who were infected with 1 of the following tickborne pathogens: Rickettsia conorii (2 patients), Rickettsia slovaca (2), Rickettsia africae (1), and Francisella tularensis (1)...
  78. ncbi A systematic study of Epstein-Barr virus serologic assays following acute infection
    Thomas D Rea
    Department of Medicine, University of Washington, Seattle, USA
    Am J Clin Pathol 117:156-61. 2002
    ..Clinicians should consider the illness stage and the laboratory technique to appropriately interpret serologic test results in suspected cases of mononucleosis caused by the Epstein-Barr virus...
  79. ncbi Leishmania infantum heat shock protein 83 for the serodiagnosis of tegumentary leishmaniasis
    B J Celeste
    Laboratorio de Soroepidemiologia e Imunobiologia, Instituto de Medicina Tropical de Sao Paulo, Universidade de Sao Paulo, Brasil
    Braz J Med Biol Res 37:1591-3. 2004
    ..When cross-reactivity was tested, chronic Chagas' disease patients (N = 10) did not show any reactivity. Therefore, we consider this L. infantum Hsp 83 to be a good antigen for routine use for serodiagnosis of tegumentary leishmaniasis...
  80. ncbi Comparative study of serologic tests for the diagnosis of asymptomatic visceral leishmaniasis in an endemic area
    Héctor Dardo Romero
    Department of Tropical Medicine and Infectology, Federal University of Triangulo Mineiro, Uberaba, MG, Brazil
    Am J Trop Med Hyg 81:27-33. 2009
    b>Serologic tests have been widely used for the diagnosis of asymptomatic visceral leishmaniasis...
  81. pmc Serodiagnosis of chronic and acute Chagas' disease with Trypanosoma cruzi recombinant proteins: results of a collaborative study in six Latin American countries
    Eufrosina S Umezawa
    Instituto de Medicina Tropical de Sao Paulo, Universidade de Sao Paulo, UNIFESP, Sao Paulo, Brazil
    J Clin Microbiol 42:449-52. 2004
    ..3%) were obtained when JL8 was combined with MAP (JM) and tested with 150 serum samples from chagasic and 142 nonchagasic individuals. Moreover, JM also diagnosed 84.2% of patients in the acute phase of T. cruzi infection...
  82. pmc Japanese spotted fever: report of 31 cases and review of the literature
    F Mahara
    Mahara Hospital, Tokushima, Japan
    Emerg Infect Dis 3:105-11. 1997
    ..Recent surveys show ticks to be the most probable vectors. As an emerging infectious disease, JSF is not commonly recognized by clinicians; therefore, even though it has not caused fatal cases, it merits careful monitoring...
  83. pmc Accuracy of enzyme-linked immunosorbent assay using crude and purified antigens for serodiagnosis of melioidosis
    Narisara Chantratita
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Clin Vaccine Immunol 14:110-3. 2007
    ..pseudomallei antigen (sensitivity, 81%; specificity, 70%), an improvement over the indirect hemagglutination assay (sensitivity, 73%; specificity, 64%)...
  84. ncbi Identification of a serodiagnostic antigen, legumain, by immunoproteomic analysis of excretory-secretory products of Clonorchis sinensis adult worms
    Jung Won Ju
    Division of Malaria and Parasitic Diseases, National Institute of Health, Seoul, Korea
    Proteomics 9:3066-78. 2009
    ..Our results illustrate the validity of immuno-proteomic approaches in the identification of serodiagnostic antigens in the parasites...
  85. pmc High frequencies of exposure to the novel human parvovirus PARV4 in hemophiliacs and injection drug users, as detected by a serological assay for PARV4 antibodies
    Colin P Sharp
    Centre for Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom
    J Infect Dis 200:1119-25. 2009
    ....
  86. ncbi Evaluation of recombinant antigens for diagnosis of melioidosis
    Elizabeth M Allwood
    Institute for Glycomics, Griffith University Gold Coast Campus, QLD, Australia
    FEMS Immunol Med Microbiol 54:144-53. 2008
    ..In contrast, the indirect ELISA using OmpA as an antigen achieved 95% sensitivity and 98% specificity. These results highlight the potential for OmpA to be used in the serodiagnosis of melioidosis in an endemic area...
  87. ncbi Inconclusive results in conventional serological screening for Chagas' disease in blood banks: evaluation of cellular and humoral response
    Célia Regina Furucho
    Laboratório de Investigação Médica cm Imunologia, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil
    Trop Med Int Health 13:1527-33. 2008
    ..To find the most reliable screening method for Trypanosoma cruzi infection in blood banks...
  88. ncbi Evaluation of immunoglobulin G4 subclass antibody in a peptide-based enzyme-linked immunosorbent assay for the serodiagnosis of human fascioliasis
    C Tantrawatpan
    Graduate Study Office, Faculty of Medicine, Thammasat University, Rangsit Campus, Pathumthani, Thailand
    Parasitology 134:2021-6. 2007
    ....
  89. ncbi Standardizing Chlamydia pneumoniae assays: recommendations from the Centers for Disease Control and Prevention (USA) and the Laboratory Centre for Disease Control (Canada)
    S F Dowell
    National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA
    Clin Infect Dis 33:492-503. 2001
    ..These standards should be applied in future investigations and periodically modified as indicated...
  90. ncbi Compararative evaluation of rK9, rK26 and rK39 antigens in the serodiagnosis of Indian visceral leishmaniasis
    Tribhuban Mohan Mohapatra
    Department of Microbiology, Institute of Medical Sciences, BHU, Varanasi, India
    J Infect Dev Ctries 4:114-7. 2010
    ..chagasi) and crude soluble antigen (CSA) for the serodiagnosis of Indian visceral leishmaniasis (VL) patients by quantitative ELISA...
  91. ncbi Serologic diagnosis of West Nile virus infection
    Pei Yong Shi
    Wadsworth Center, New York State Department of Health, Albany 12201, USA
    Expert Rev Mol Diagn 3:733-41. 2003
    ..The nonstructural protein 5 protein-based assay can reliably discriminate between WNV and dengue or St. Louis encephalitis virus, as well as between natural WNV infection and flavivirus vaccination...
  92. pmc Bartonella quintana and Coxiella burnetii as causes of endocarditis, India
    Nandhakumar Balakrishnan
    Emerg Infect Dis 14:1168-9. 2008
  93. ncbi Serodiagnosis of flaviviral infections and vaccinations in humans
    Goro Kuno
    Arbovirus Diseases Branch, Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado 80522, USA
    Adv Virus Res 61:3-65. 2003
  94. pmc Poor performance of a novel serological test for diagnosis of pulmonary tuberculosis in Bangui, Central African Republic
    Eric Kassa-Kelembho
    Institut Pasteur de Madagascar, BP 1274, Antananarivo 101, Madagascar
    Clin Vaccine Immunol 13:702-3. 2006
    ..6% versus 80.9%, respectively; P < 0.000001)...
  95. ncbi A comparison of four serologic assays in screening for Brucella exposure in Hawaiian monk seals
    O Nielsen
    Department of Fisheries and Oceans, Central and Arctic Region, 501 University Crescent, Winnipeg, Manitoba, Canada R3T 2N6
    J Wildl Dis 41:126-33. 2005
    ..in this species...
  96. ncbi Serological diagnosis and follow-up of asymptomatic and acute Q fever infections
    Christiane Wagner-Wiening
    Q fever Consulting Laboratory, Baden Wurttemberg, State Health Office, Wiederholdstr 15, D 70174 Stuttgart, Germany
    Int J Med Microbiol 296:294-6. 2006
    ..We therefore conclude that the exclusion of chronic Q fever infection by a single serological examination cannot be done. At least three consecutive tests should be performed, that is 3, 6, and 9 months after initial Q fever infection...
  97. pmc Development, implementation, and impact of acceptability criteria for serologic tests for infectious diseases
    John A Crump
    Clinical Microbiology Laboratory, Duke University Medical Center, Duke University School of Medicine, Durham, North Carolina 27710, USA
    J Clin Microbiol 42:881-3. 2004
    ..All parts of the diagnostic process must be optimized to ensure that serologic tests perform adequately...
  98. ncbi Analysis of thioredoxin peroxidase as a promising antigen for diagnosis of Fasciola gigantica infection: a preliminary study
    Weiyu Zhang
    College of Animal Science and Technology, Guangxi University, 530005 Nanning, China
    Parasitol Int 60:206-8. 2011
    ..gigantica but not by healthy animals...
  99. ncbi A low molecular weight lipopolysaccharide antigen preparation reactive to acute leptospirosis heterologous sera
    M Riazi
    School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia
    Trop Biomed 27:241-53. 2010
    ..This study showed that the 10-15 kDa antigen could potentially be useful for serodiagnosis of acute leptospirosis in Malaysia...
  100. ncbi A prospective study of the influence of HIV status on the seroreversion of serological tests for syphilis
    M Janier
    Sexually Transmitted Diseases Clinic, , Paris, France
    Dermatology 198:362-9. 1999
    ..Evolution of the VDRL test after therapy is regular in HIV+ patients. The VDRL test remains adequate for controlling the efficacy of treatment in these patients...
  101. ncbi Burkholderia pseudomallei-specific recombinant protein and its potential in the diagnosis of melioidosis
    P Wongprompitak
    Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    Asian Pac J Allergy Immunol 19:37-41. 2001
    ..A combination of such antigens should provide materials for successful serodiagnosis of melioidosis in the endemic areas...

Research Grants62

  1. Hospital - Based Surveillance of Acute Febrile Illness in Western Ghat Region of
    ARUNKUMAR GOVINDAKARNAVAR; Fiscal Year: 2013
    ..Clinical samples also will be tested for unknown pathogens using PCR- sequence based pathogen discovery techniques. PHS 398/2590 (Rev. 06/09) Page 1 Continuation Format Page ..
  2. Case-Cohort Study of Cancers in Excess in Poultry Workers
    Eric S Johnson; Fiscal Year: 2013
    ..This occupational group has not been studied before for cancer occurrence in spite of having these hazardous carcinogenic exposures. ..
  3. Seriodiagnostic arrays for biodefense and emerging infectious diseases
    DAVID HUW DAVIES; Fiscal Year: 2010
    ....
  4. Proteome-wide screen for M. tuberculosis antigens
    Robert N Husson; Fiscal Year: 2010
    ..Illnesses with overlapping manifestations make clinical diagnosis of TB unreliable. Serologic tests are used to diagnose many infectious diseases, and have the advantages of high sensitivity and specificity, ..
  5. Diagnostic Assays for early Lyme Borreliosis using in-vivo expressed antigens
    Michel Ledizet; Fiscal Year: 2012
    ..b>Serologic tests (ELISA and immunoblot) that detect antibodies against B...
  6. A New Cytokine-Based Immunoassay for the Diagnosis of Lyme Disease
    Linda K Bockenstedt; Fiscal Year: 2013
    ..Currently, serologic tests that detect Bb-reactive antibodies are the mainstay of LD diagnostics, but have low sensitivity early in ..
  7. Gene Expression Biomarkers for Diagnosis of Lyme Disease
    IRA S SCHWARTZ; Fiscal Year: 2012
    ..Once identified, this subset of classifier genes could be employed as the basis for development of a sensitive and specific gene-based diagnostic test for active B. burgdorferi infection. ..
  8. Randomized Trial of IFCBT-HIVPI to Prevent HIV Among Non-Injection Drug Users
    William W Latimer; Fiscal Year: 2013
    ..tools to assess attitudes and behavior change skills targeted by IFCBT-HIVPI, drug and STI urine testing, and serologic tests of HIV will be administered before, during, and after the intervention interval across 18-month post-..
  9. A serologic assay to measure successful Lyme borreliosis antibiotic therapy
    Michel Ledizet; Fiscal Year: 2010
    ..b>Serologic tests (ELISA and immunoblot) that detect antibodies against B...
  10. DEK and TNF inhibitors in juvenile arthritis
    DAVID MICHAEL MARKOVITZ; Fiscal Year: 2012
    ..Within the context of a clinical trial that will address the key issue of when it is appropriate to discontinue anti-TNF therapy in patients with JIA, we propose to study the role of DEK in the pathogenesis and management of JIA. ..
  11. Adapt Integrated Family CBT into HIV Prevention Intervention for Pregnant Women
    William Latimer; Fiscal Year: 2009
    ..risk behavior and psychiatric disorders, neuropsychological tests, self-report tools, urine drug testing, and serologic tests of HIV and hepatitis A, B, and C viruses administered at multiple points before (1 baseline assessment), ..
  12. Serologic test for neonatal hemochromatosis in infants with acute liver failure
    PETER FRANK WHITINGTON; Fiscal Year: 2010
    ..Since NH is responsive to medical treatment, improving the diagnosis of acute liver failure could save the lives of many infants and substantially reduce the need for liver transplantation in children. ..
  13. Antigenic Relationships of SARS and Animal Coronaviruses
    Linda Saif; Fiscal Year: 2006
    ..for the cross-reactivity using N and S fragments and truncate this region to eliminate cross-reactivity in serologic tests to make SARS CoV specific assays...
  14. Rickettsia ricketti and Rickettsia-like organisms in Maryland
    Douglas Norris; Fiscal Year: 2009
    ..The serologic tests commonly used to confirm infections such as RMSF do not differentiate between members of the SFG rickettsiae ..
  15. A new serum test for the differential diagnosis of pituitary masses
    Patrizio Caturegli; Fiscal Year: 2010
    ..This grant is designed to develop an antibody- based serologic test to aid in the differential diagnosis of these common conditions. Such test could avoid unnecessary pituitary surgeries to patients with autoimmune hypophysitis. ..
  16. Multiplexed POC Diagnostic System for Bio-Threat Agents
    GEORGE SIGAL; Fiscal Year: 2005
    ..The system is designed to be used by personnel without specialized training and will require no pre-processing of samples. ..
  17. HIV ASSOCIATED NEPHROPATHY IN CHILDREN
    JOSE STRAUSS; Fiscal Year: 1993
    ..An effort will also be made to identify certain clinical indicators which can predict the development of, or correlate with the severity of, the renal disease...
  18. Peptide-Based Serological Test for Cysticercosis
    VICTOR KOVALENKO; Fiscal Year: 2007
    ..The primary application of these tests will be the diagnosis of neurocysticercosis in humans, pig cysticercosis, seroepidemiological surveys and community-based studies. [unreadable] [unreadable] [unreadable]..
  19. CELIAC DISEASE IN OSTEOPOROSIS
    WILLIAM STENSON; Fiscal Year: 2004
    ..Studies under this Specific Aim will also allow recommendation for which sequence of serologic tests is most likely to be helpful in identifying patients with osteoporosis who also have celiac disease. 2...
  20. Targeted DNA extraction for Tuberculosis PCR from sputum
    Eric Houpt; Fiscal Year: 2007
    ..e., weeks), limiting clinical utility. Novel serologic tests are in development but thus far have been fraught with poor sensitivity and specificity...
  21. RANDOMIZED HEPATITIS B VACCINE DELIVERY TRIAL FOR IDUS
    Karen Seal; Fiscal Year: 2000
    ..Cohort participants will be screened with serologic tests for hepatitis B surface antigen (HBsAg), antibody to HBsAg (anti-HBs), and antibody to hepatitis B core ..
  22. SYNTHETIC PEPTIDE AS CAPTURE AG FOR PARVOVIRUS B19 IGG/M
    PAUL MARIE HONHON; Fiscal Year: 1990
    ..Epitopes that significantly react with disease state sera will be used in the development of a prototype ELISA. This project will lead directly to Phase II clinical evaluations and thence to Phase III marketing...
  23. RECOMBINANT DENGUE VIRUS ANTIGEN PRODUCTION
    Helene Paxton; Fiscal Year: 2000
    ..b>Serologic tests, widely used as diagnostic aids, rely on relatively nonspecific whole virus antigens...
  24. HETEROSEXUAL TRANSMISSION OF HIV
    Margaret Fischl; Fiscal Year: 1991
    ..Laboratory tests will include T- cell enumeration, serologic tests for hepatitis, syphilis, cytomegalovirus, chlamydia, and HIV, and cultures for gonorrhea, herpes, and HIV...
  25. Novel Point-of-Care Multiplex Lyme Disease Test
    Hiep Tran; Fiscal Year: 2009
    ..It is inexpensive, less than $20 per test, robust, requires only a single step, user-friendly, and temperature stable, with no requirement for sample processing. The results can be read in 10 to 30 minutes. ..
  26. RAPID SAFE & INEXPENSIVE IMMUNOASSAY FOR LYME DISEASE
    TSUE MING LIN; Fiscal Year: 1991
    ..With defined clinical features and serologic tests, LD has been reported in increasing number worldwide...
  27. Developing a new rapid test for human African trypanosomiasis
    Darrick Carter; Fiscal Year: 2009
    ..By discovering and validating candidate antigens we intend to progress toward a commercial prototype for such a test leading to an improvement in global health. ..
  28. FATAL HERPESVIRUS IN ELEPHANTS
    Laura Richman; Fiscal Year: 2002
    ..in conjunction with intensive research in characterization of the elephant herpesvirus, under the direction of my mentor, Dr. Hayward. ..
  29. HIV RISK REDUCTION THROUGH HSV-2 PREVENTION WITH N-9
    Nancy Padian; Fiscal Year: 2002
    ..Baseline clinical, microbiologic, and laboratory data, including HIV and HSV-2 serologic tests will be obtained...
  30. Clinical Suspicion of TB: A Technology Assessment Tool
    Antonino Catanzaro; Fiscal Year: 2007
    ..tests can be used to assist in rapid diagnosis of TB, and 3) establish a serum bank for screening of future serologic tests for TB. It will help define the role of serologic testing in the diagnosis of PTB.
  31. PHOSPHOLIPASE: A TARGET TO DIAGNOSE INVASIVE CANDIDIASIS
    STEVEN KLEIBOEKER; Fiscal Year: 2006
    ..The effectiveness of each approach will be evaluated in established experimental animal models of invasive and mucosal candidiasis and patients with culture-proven invasive candidiasis and controls for the study. ..
  32. Peptide-Based Serodiagnostic Test for Cysticercosis
    VICTOR KOVALENKO; Fiscal Year: 2005
    ..Phase 2 will comprise additional optimization of selected formats, validation using larger panels of human and porcine specimens, and clinical evaluation under field conditions. ..
  33. MOLECULAR DIAGNOSTIC TESTS FOR SIMIAN HERPESVIRUSES
    R Eberle; Fiscal Year: 2005
    ....
  34. Novel Molecular Markers of Human Colon Neoplasia
    Sanford Markowitz; Fiscal Year: 2009
    The goal of this proposal is to develop serologic tests for early detection of colorectal neoplasia and colon cancer. Colorectal cancer is the second leading cause of cancer death...
  35. EARLY DIAGNOSIS OF PERINATAL HIV-1 INFECTION
    SUSAN HUTTO; Fiscal Year: 1993
    ..These studies may shed light on factors that influence the transmission of HIV-1 from mother to infant, and on factors associated with progression to disease...
  36. Diagnostic Assays for Rheumatic Diseases
    John Harley; Fiscal Year: 2001
    ....
  37. Adapt US Version of IFCBT-HIVPI to Prevent HIV among Drug Users in South Africa
    William Latimer; Fiscal Year: 2009
    ..tests, tools designed to assess behavior change processes targeted by IFCBT-HIVPI, urine drug testing, and serologic tests of HIV will also be administered before (1 baseline assessment), during (1 process assessment), and after (1 ..
  38. NINTH INTERNATIONAL SYMPOSIUM ON CELIAC DISEASE
    Alessio Fasano; Fiscal Year: 2000
    ....
  39. A Comprehensive Investigation of Viral-induced Lymphomagenesis
    Susan G Fisher; Fiscal Year: 2010
    ..detection techniques;to evaluate the role of SV-40 in lymphomagenesis;and to develop/optimize specific serologic tests for addressing viral transmissiblility within familial clusters...
  40. OSPA NEGATIVE TEST DEVELOPMENT FOR LYME DISEASE
    PHILIP MOLLOY; Fiscal Year: 2000
    ..S. Since the most widely used serologic tests for Lyme disease utilize a whole-cell sonicate of OspA-containing B...
  41. PATHOGENETIC AND VIROLOGIC ASPECTS OF PEDIATRIC AIDS
    WARREN ANDIMAN; Fiscal Year: 1992
    ..Another important goal is to develop virologic and serologic tests and to identify epidemiologic and behavioral risk factors to characterize mothers whose infants have a high ..
  42. A Structure based Serological Test for Cervical Cancer
    Arnold Satterthwait; Fiscal Year: 2002
    ....
  43. ROLE OF L-FORMS IN INFLAMMATORY BOWEL DISEASE
    John Bartlett; Fiscal Year: 1980
    ..b>Serologic tests and cultures will also be performed in animals challenged with bowel tissue to support or refute the ..
  44. Study of risk factors of tick-borne encephalitis in Poland
    Pawel Stefanoff; Fiscal Year: 2009
    ....
  45. Treatment of Acute Hepatitis C in Injection Drug Users
    Anna Wald; Fiscal Year: 2005
    ..abstract_text> ..
  46. 5 NUCLEASE ASSAYS FOR RODENT HEALTH MONITORING
    David Besselsen; Fiscal Year: 2002
    ..FFPNA will greatly enhance the diagnostic capabilities for routine health monitoring of laboratory rodents and will provide a viable, cost-effective alternative for RAP testing. ..
  47. Are IQs low in offspring of euthyroid women with low T4
    Wendy Craig; Fiscal Year: 2008
    ..It is intended that the study be continued for five more years (total of 10) in order to obtain additional estimates of neuropsychological development in the children at a time when more extensive testing can be performed. ..
  48. PATHOGENESIS OF MURINE PARVOVIRUS FIELD STRAINS
    David Besselsen; Fiscal Year: 2007
    ..In addition, these studies will provide information about perturbations in host physiology and gene expression induced by murine parvoviruses, and basic scientific information about parvovirus host interaction. ..
  49. Diagnosis and Pathogenesis of Early Lyme Disease
    Allen Steere; Fiscal Year: 2007
    ..In addition, greater knowledge of spirochetal virulence and host factors associated with severe disease may allow the development of laboratory markers for patients who would benefit from more intensive treatment. ..
  50. Topical Antibiotics to Prevent Lyme Disease
    Gary Wormser; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  51. Virulence and Immunity of Granulocytic Ehrlichiae
    JOHN DUMLER; Fiscal Year: 2005
    ..This information will provide the framework for rational design of new therapies aimed at modulating immune mechanisms and design of preventative measures aimed at immunization. ..
  52. Host defense functions of M. tuberculosis lipoglycan
    Edward Chan; Fiscal Year: 2005
    ..3. To elucidate the role of the TLRs, MAPK and NFkB signaling pathways, and ManLAM in controlling the growth of M. tuberculosis in mouse and human macrophages and to correlate effects on growth with NO* and TNFa expression. ..
  53. LYME ARTHRITIS: A NEW EPIDEMIC DISEASE
    Allen C Steere; Fiscal Year: 2010
    ..Furthermore, this work brings us closer to the long-term goal of direct comparisons of antigens in Lyme arthritis and rheumatoid arthritis synovia. ..
  54. Virulence and Immunity of Granulocytic Ehrlichiae
    JOHN DUMLER; Fiscal Year: 2007
    ..This information will provide a framework for rational design of therapies aimed at modulating immune injury and could foster design of preventative measures aimed at immunization. ..
  55. Scanning the F. tularensis Proteome for Vaccine Antigens
    Philip Felgner; Fiscal Year: 2006
    ..tularensis infection, the responsive antigens identified by the Vaccine Antigen Scan will be candidates for use in a DNA or subunit vaccine. ..
  56. Scanning the P. falciparum proteome for vaccine antigens
    Philip Felgner; Fiscal Year: 2006
    ..abstract_text> ..
  57. NOVEL DEVICES FOR RAPID BLOOD COMPATIBILITY TESTING
    John Roback; Fiscal Year: 2004
    ..The results of the multi-center trial (to be completed during Phase Ill) will lead to an FDA 510(k) application. ..
  58. ONTOGENY OF RSV-SPECIFIC B CELL RESPONSES IN HUMANS
    James Crowe; Fiscal Year: 2001
    ..The data from this work will direct decisions about the best vaccine strategy to use against RSV in neonates, and will delineate basic mechanisms of the ontogeny of B-cell repertoire diversity in humans. ..
  59. Multiplex PCR Detection of CDC 'A' Bioterrorism Agents
    Kelly Henrickson; Fiscal Year: 2005
    ..Specific Aim 4: To determine if this multiplex assay is equivalent to these "singleplex" assays in a clinical trial. ..
  60. AUTOANTIBODIES AS MARKERS OF BREAST CANCER
    FELIX FERNANDEZ MADRID; Fiscal Year: 2002
    ..Associations will be sought between serum reactivities, patient diagnosis and existing ten-year outcome data to assess the potential diagnostic and prognostic value of each antigen. ..
  61. Role of memory T cell dynamics in SIV infection
    Louis Picker; Fiscal Year: 2007
    ..abstract_text> ..
  62. Hematopoietic Stem Cell Donor Enrollment and Retention in Korean Americans
    John Choe; Fiscal Year: 2008
    ..Ultimately, we hope to increase the likelihood of successful stem cell transplant among Asian/Pacific Islander patients. [unreadable] [unreadable] [unreadable] [unreadable]..