hematocrit

Summary

Summary: The volume of packed RED BLOOD CELLS in a blood specimen. The volume is measured by centrifugation in a tube with graduated markings, or with automated blood cell counters. It is an indicator of erythrocyte status in disease. For example, ANEMIA shows a low value; POLYCYTHEMIA, a high value.

Top Publications

  1. pmc Simultaneous measurement of RBC velocity, flux, hematocrit and shear rate in vascular networks
    Walid S Kamoun
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Nat Methods 7:655-60. 2010
  2. ncbi Faster oxygen uptake kinetics at the onset of submaximal cycling exercise following 4 weeks recombinant human erythropoietin (r-HuEPO) treatment
    Philippe Connes
    UPRES EA 2991, Laboratoire Sport Performance Santé, Faculte des Sciences du Sport, Universite Montpellier 1, 34090 Montpellier, France
    Pflugers Arch 447:231-8. 2003
  3. ncbi Hemorheological parameters as determinants of myocardial tissue hematocrit values
    O K Baskurt
    Department of Physiology, Akdeniz University Faculty of Medicine, Antalya, Turkey
    Clin Hemorheol Microcirc 35:45-50. 2006
  4. ncbi Hemoconcentration and hemostasis during acute stress: interacting and independent effects
    Anthony W Austin
    Department of Psychology, Ohio University, Athens, OH, USA
    Ann Behav Med 42:153-73. 2011
  5. ncbi Trypanosoma vivax: mechanical transmission in cattle by one of the most common African tabanids, Atylotus agrestis
    Marc Desquesnes
    CIRAD EMVT, Centre de coopération Internationale en Recherche Agronomique pour le Développement département Elevage et Médecine Vétérinaire Tropicale, BP 5035, 34032 Montpellier, France
    Exp Parasitol 103:35-43. 2003
  6. ncbi In vivo CYP3A4 activity, CYP3A5 genotype, and hematocrit predict tacrolimus dose requirements and clearance in renal transplant patients
    H de Jonge
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
    Clin Pharmacol Ther 92:366-75. 2012
  7. ncbi Endothelial progenitor cell proliferation and differentiation is regulated by erythropoietin
    Ferdinand H Bahlmann
    Division of Nephrology, Department of Internal Medicine, Hanover Medical School, Hanover, Germany
    Kidney Int 64:1648-52. 2003
  8. ncbi Impact of alterations in total hemoglobin mass on VO 2max
    Walter Schmidt
    Department of Sports Medicine Sports Physiology, University of Bayreuth, Germany
    Exerc Sport Sci Rev 38:68-75. 2010
  9. ncbi Clinical profile of homozygous JAK2 617V>F mutation in patients with polycythemia vera or essential thrombocythemia
    Alessandro M Vannucchi
    Department of Hematology, University of Florence, 50134 Florence, Italy
    Blood 110:840-6. 2007
  10. ncbi Nitric oxide scavenging by red blood cells as a function of hematocrit and oxygenation
    Ivan Azarov
    Department of Physics, School of Medicine, Wake Forest University, Winston Salem, North Carolina 27109, USA
    J Biol Chem 280:39024-32. 2005

Detail Information

Publications314 found, 100 shown here

  1. pmc Simultaneous measurement of RBC velocity, flux, hematocrit and shear rate in vascular networks
    Walid S Kamoun
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Nat Methods 7:655-60. 2010
    ..We developed methodologies for simultaneously quantifying blood flow (velocity, flux, hematocrit and shear rate) in extended networks at single-capillary resolution in vivo...
  2. ncbi Faster oxygen uptake kinetics at the onset of submaximal cycling exercise following 4 weeks recombinant human erythropoietin (r-HuEPO) treatment
    Philippe Connes
    UPRES EA 2991, Laboratoire Sport Performance Santé, Faculte des Sciences du Sport, Universite Montpellier 1, 34090 Montpellier, France
    Pflugers Arch 447:231-8. 2003
    ..5+/-7.3 vs. 33.4+/-7.9 s). Collectively, our findings suggest that r-HuEPO contributes both to an acceleration of the dynamic response of VO2 to submaximal exercise and to an increase in maximal exercise capacity...
  3. ncbi Hemorheological parameters as determinants of myocardial tissue hematocrit values
    O K Baskurt
    Department of Physiology, Akdeniz University Faculty of Medicine, Antalya, Turkey
    Clin Hemorheol Microcirc 35:45-50. 2006
    It is well known that the hematocrit in microvessels with diameters smaller than 1000 microm is lower than either venous or arterial hematocrit, thereby resulting in significantly lower mean hematocrit values for vessels perfusing a given ..
  4. ncbi Hemoconcentration and hemostasis during acute stress: interacting and independent effects
    Anthony W Austin
    Department of Psychology, Ohio University, Athens, OH, USA
    Ann Behav Med 42:153-73. 2011
    ..It is unclear whether these effects are independent or have influence on each other...
  5. ncbi Trypanosoma vivax: mechanical transmission in cattle by one of the most common African tabanids, Atylotus agrestis
    Marc Desquesnes
    CIRAD EMVT, Centre de coopération Internationale en Recherche Agronomique pour le Développement département Elevage et Médecine Vétérinaire Tropicale, BP 5035, 34032 Montpellier, France
    Exp Parasitol 103:35-43. 2003
    ..congolense, T. brucei, and most often T. vivax as well; however, in areas where T. vivax can be mechanically transmitted, clearance of tsetse may not be sufficient to eradicate livestock trypanosomosis...
  6. ncbi In vivo CYP3A4 activity, CYP3A5 genotype, and hematocrit predict tacrolimus dose requirements and clearance in renal transplant patients
    H de Jonge
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
    Clin Pharmacol Ther 92:366-75. 2012
    ..b>Hematocrit explains an additional 4-14%...
  7. ncbi Endothelial progenitor cell proliferation and differentiation is regulated by erythropoietin
    Ferdinand H Bahlmann
    Division of Nephrology, Department of Internal Medicine, Hanover Medical School, Hanover, Germany
    Kidney Int 64:1648-52. 2003
    ..We tested the hypothesis that darbepoetin alfa [i.e., a recombinant analogue of the cytokine erythropoietin (EPO)] stimulates proliferation and differentiation of EPCs...
  8. ncbi Impact of alterations in total hemoglobin mass on VO 2max
    Walter Schmidt
    Department of Sports Medicine Sports Physiology, University of Bayreuth, Germany
    Exerc Sport Sci Rev 38:68-75. 2010
    ..Blood doping mimics the altitude effects, however, by far exceeding its magnitude...
  9. ncbi Clinical profile of homozygous JAK2 617V>F mutation in patients with polycythemia vera or essential thrombocythemia
    Alessandro M Vannucchi
    Department of Hematology, University of Florence, 50134 Florence, Italy
    Blood 110:840-6. 2007
    ..Irrespective of their clinical diagnosis, homozygous patients were older, displayed a higher leukocyte count and hematocrit value at diagnosis, and presented larger spleen volume...
  10. ncbi Nitric oxide scavenging by red blood cells as a function of hematocrit and oxygenation
    Ivan Azarov
    Department of Physics, School of Medicine, Wake Forest University, Winston Salem, North Carolina 27109, USA
    J Biol Chem 280:39024-32. 2005
    ..of the uptake rate of nitric oxide by red blood cells under oxygenated and deoxygenated conditions at different hematocrit percentages...
  11. ncbi Reduced kidney function and anemia as risk factors for mortality in patients with left ventricular dysfunction
    A Al-Ahmad
    Division of Cardiology, Department of Medicine, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Am Coll Cardiol 38:955-62. 2001
    OBJECTIVES: We sought to evaluate the relationship between the level of kidney function, level of hematocrit and their interaction on all-cause mortality in patients with left ventricular (LV) dysfunction...
  12. ncbi Association of hematocrit value with cardiovascular morbidity and mortality in incident hemodialysis patients
    Suying Li
    Nephrology Analytical Services, Minneapolis Medical Research Foundation, Minneapolis, Minnesota 55404, USA
    Kidney Int 65:626-33. 2004
    Associations between hematocrit values and clinical outcome have been studied with conflicting results in cardiac patients, end-stage renal disease (ESRD) patients, and ESRD patients with cardiac disease...
  13. ncbi Determination of optical properties of human blood in the spectral range 250 to 1100 nm using Monte Carlo simulations with hematocrit-dependent effective scattering phase functions
    Moritz Friebel
    Laser und Medizin Technologie GmbH, Berlin, Germany
    J Biomed Opt 11:34021. 2006
    ..coefficient mu(a), scattering coefficient mu(s), and anisotropy factor g of diluted and undiluted human blood (hematocrit 0.84 and 42...
  14. ncbi Altitude adaptation through hematocrit changes
    G R Zubieta-Calleja
    High Altitude Pathology Institute IPPA, Box 2852, La Paz, Bolivia
    J Physiol Pharmacol 58:811-8. 2007
    ..mountain sickness (CMS or polyerythrocythemia) can occur; 2) subacute, from 72 hours until the slope of the hematocrit increase with time is zero; here high altitude subacute heart disease can occur; and 3) chronic, where the ..
  15. ncbi Effects of hematocrit and oxygen saturation level on blood spin-lattice relaxation
    M Johanna Silvennoinen
    Department of Biomedical NMR and National Bio NMR Facility, A I Virtanen Institute, University of Kuopio, Finland
    Magn Reson Med 49:568-71. 2003
    In the present study blood T(1) was determined as a function of hematocrit and oxygen saturation. T(1) showed a significant linear dependency on both of these parameters...
  16. ncbi Changes of hematocrit and hemoglobin concentration in the cold Himalayan environment in dependence on total body fluid
    Markus Tannheimer
    Department of Visceral and Thoracic Surgery, Armed Forces Hospital Ulm, Ulm, Germany
    Sleep Breath 14:193-9. 2010
    ..Therefore, the influence of water distribution on hemoglobin (Hb) and hematocrit (Hct) values during a long-term exposure at high altitude was investigated.
  17. ncbi Prolonged administration of recombinant human erythropoietin increases submaximal performance more than maximal aerobic capacity
    J J Thomsen
    Copenhagen Muscle Research Centre, Rigshospitalet, Section 7652, 2100, Copenhagen Ø, Denmark
    Eur J Appl Physiol 101:481-6. 2007
    ..8% as compared to pre rHuEpo administration. In conclusion, in healthy non-athlete subjects rHuEpo administration prolongs submaximal exercise performance by about 54% independently of the approximately 12% increase in VO2max...
  18. ncbi Changes in blood volume and hematocrit during acute preoperative volume loading with 5% albumin or 6% hetastarch solutions in patients before radical hysterectomy
    M Rehm
    , , Klinikum Grosshadern, Munich, Germany
    Anesthesiology 95:849-56. 2001
    ..volume (indocyanine green dilution technique), erythrocyte volume (labeling erythrocytes with fluorescein), hematocrit, total protein, and hetastarch plasma concentrations (group II) were measured before and 30 min after the end of ..
  19. ncbi Lowest hematocrit on bypass and adverse outcomes associated with coronary artery bypass grafting. Northern New England Cardiovascular Disease Study Group
    G R DeFoe
    Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Ann Thorac Surg 71:769-76. 2001
    ..Cardiac surgery patients' hematocrits frequently fall to low levels during cardiopulmonary bypass...
  20. pmc Bradykinin- and sodium nitroprusside-induced increases in capillary tube haematocrit in mouse cremaster muscle are associated with impaired glycocalyx barrier properties
    Jurgen W G E VanTeeffelen
    Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    J Physiol 586:3207-18. 2008
    ..Modulation of glycocalyx volume might represent a novel mechanism of perfusion control at the capillary level...
  21. ncbi Death, hospitalization, and economic associations among incident hemodialysis patients with hematocrit values of 36 to 39%
    A J Collins
    Hennepin County Medical Center, Minneapolis, Minnesota
    J Am Soc Nephrol 12:2465-73. 2001
    Anemia treatment with epoetin has led to dramatic increases in hematocrit levels since 1989...
  22. ncbi Adverse effects of low hematocrit during cardiopulmonary bypass in the adult: should current practice be changed?
    Robert H Habib
    Cardiovascular Surgery, St Vincent Mercy Medical Center, Toledo, Ohio, 43608, USA
    J Thorac Cardiovasc Surg 125:1438-50. 2003
    ..In adult bypass, the nadir hematocrit can vary widely with body size and prebypass hematocrit variations, yet its effects on perioperative organ ..
  23. ncbi Time course and mechanisms of hemoconcentration in response to mental stress
    Dolf de Boer
    Behavioural Medicine Group, School of Sport and Exercise Sciences, University of Birmingham, B15 2TT Birmingham, UK
    Biol Psychol 72:318-24. 2006
    ..In the present study, hematocrit was measured repeatedly at baseline, during a 4 min mental stress task and during 20 min of recovery...
  24. pmc Usefulness of the blood hematocrit level to predict development of heart failure in a community
    Erin E Coglianese
    Framingham Heart Study, Massachusetts, USA
    Am J Cardiol 109:241-5. 2012
    ..We hypothesized that higher hematocrit (HCT) would be associated with an increased incidence of new-onset HF in the community...
  25. pmc Influence of recombinant human erythropoietin treatment on pulmonary O2 uptake kinetics during exercise in humans
    Daryl P Wilkerson
    Department of Exercise and Sport Science, Manchester Metropolitan University, Alsager, UK
    J Physiol 568:639-52. 2005
    ....
  26. ncbi Cerebral venous sinus density on noncontrast CT correlates with hematocrit
    D F Black
    Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA
    AJNR Am J Neuroradiol 32:1354-7. 2011
    ....
  27. pmc Neurocognitive profiles of preterm infants randomly assigned to lower or higher hematocrit thresholds for transfusion
    Thomasin E McCoy
    Department of Pediatrics, University of Iowa, Iowa City, IA 52245, USA
    Child Neuropsychol 17:347-67. 2011
    ..The purpose of this study is to evaluate long-term neurocognitive outcome on children born prematurely and treated at birth with different transfusion guidelines...
  28. ncbi Revised European best practice guidelines for the management of anaemia in patients with chronic renal failure
    Francesco Locatelli
    Nephrol Dial Transplant 19:ii1-47. 2004
  29. ncbi High-dose vitamin C infusion reduces fluid requirements in the resuscitation of burn-injured sheep
    Michael A Dubick
    U S Army Institute of Surgical Research, San Antonio, Texas 78234 6315, USA
    Shock 24:139-44. 2005
    ..In this sheep burn model, continuous high-dose VC infusion reduced net fluid balance, reduced indices of plasma lipid peroxidation, and maintained overall antioxidant status in comparison with standard-of-care LR treatment...
  30. pmc A theoretical framework for estimating cerebral oxygen metabolism changes using the calibrated-BOLD method: modeling the effects of blood volume distribution, hematocrit, oxygen extraction fraction, and tissue signal properties on the BOLD signal
    Valerie E M Griffeth
    Department of Bioengineering, University of California, San Diego, CA 92093, USA
    Neuroimage 58:198-212. 2011
    ..For a 3Tesla field and a dominant arterial volume change with activation, the accuracy of the Davis model is improved with new values of α=0.14 and β=0.91...
  31. ncbi Effect of hepatitis C virus on hemoglobin and hematocrit levels in saudi hemodialysis patients
    Khalid A Alsaran
    Prince Salman Center for Kidney Disease, Riyadh, Kingdom of Saudi Arabia
    Ren Fail 31:349-54. 2009
    ....
  32. ncbi Efficacy of copper oxide wire particles against gastrointestinal nematodes in sheep and goats
    F Soli
    Fort Valley State University, Fort Valley, GA 31030, USA
    Vet Parasitol 168:93-6. 2010
    ..In this study, COWP treatment was equally effective against H. contortus infection in lambs and kids and appears to be an effective method of controlling H. contortus infection for up to 6 weeks in small ruminants following weaning...
  33. ncbi Cardiovascular benefits in moderate increases of blood and plasma viscosity surpass those associated with lowering viscosity: Experimental and clinical evidence
    B Y Salazar Vázquez
    Faculty of Medicine, Universidad Juarez del Estado de Durango, Victoria de Durango, Dgo, Mexico
    Clin Hemorheol Microcirc 44:75-85. 2010
    ..Blood viscosity, primarily dependent on hematocrit (Hct) is a determinant of peripheral vascular resistance, and therefore blood pressure...
  34. ncbi Factors contributing to higher hematocrit levels in hemodialysis patients not receiving recombinant human erythropoietin
    Atsushi Takeda
    Kidney Center and Central Laboratory, Tsuchiura Kyodo General Hospital, Ibaraki, Japan
    Am J Kidney Dis 40:104-9. 2002
    ..To keep the target hematocrit of 30%, 133 patients (84%) were administered rHuEPO, but 25 patients (16%) did not need rHuEPO...
  35. ncbi Urinary excretion of exogenous glycerol administration at rest
    Karsten Koehler
    Institute of Biochemistry, German Sport University, Cologne, Germany
    Drug Test Anal 3:877-82. 2011
    ..Even though there were significant reductions in haemoglobin and haematocrit after 2.5 h, the plasma expansion by glycerol appeared rather marginal in comparison to placebo...
  36. ncbi Prenatal cigarette smoke exposure: pregnancy outcome and gestational changes in plasma nicotine concentration, hematocrit, and carboxyhemoglobin in a newly standardized rat model
    Svetlana Farkas
    Department of Pediatrics, Institute of Maternal and Child Health, Health Sciences Center, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1
    Toxicol Appl Pharmacol 214:118-25. 2006
    ..smokers (20-60 ng/ml), (2) investigate the temporal changes in plasma Nic concentrations, carboxyhemoglobin, and hematocrit with advancing pregnancy, and (3) elucidate the effects of CS exposure on pregnancy outcome...
  37. ncbi Cerebral oxygen transport failure?: decreasing hemoglobin and hematocrit levels after ischemic stroke predict poor outcome and mortality: STroke: RelevAnt Impact of hemoGlobin, Hematocrit and Transfusion (STRAIGHT)--an observational study
    Lars Kellert
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Stroke 42:2832-7. 2011
    Although conceivably relevant for penumbra oxygenation, the optimal levels of hemoglobin (Hb) and hematocrit (Hct) in patients with acute ischemic stroke are unknown.
  38. ncbi Baseline cerebral oximetry values in elderly patients with hip fractures: a prospective observational study
    Georgios Papadopoulos
    Department of Anaesthesiology and Postoperative Intensive Care, University of Ioannina School of Medicine, Ioannina, Greece
    Injury 42:1328-32. 2011
    ..This study was conducted to evaluate baseline cerebral tissue regional oxygen saturation (rSO(2)) values and identify risk factors related to severe rSO(2) reductions in elderly patients with hip fractures...
  39. ncbi Increase in testicular temperature and vascularization induced by hypobaric hypoxia in rats
    Jorge G Farias
    Laboratorio de Biomedicina de Altura, Instituto de Estudios de la Salud, Universidad Arturo Prat, Iquique, Chile
    J Androl 26:693-7. 2005
    ..Morphological classification of interstitial blood vessels indicates a transition from capillaries to larger vessels as the hypoxia exposure progresses...
  40. pmc Neuroprotection of photoreceptors by direct delivery of erythropoietin to the retina of the retinal degeneration slow mouse
    Tonia S Rex
    The Hamilton Eye Institute, Department of Ophthalmology, The University of Tennessee Health Science Center, 930 Madison Ave, Ste 731, Memphis, TN 38163, USA
    Exp Eye Res 89:735-40. 2009
    ..to the photoreceptors in the retinal degeneration slow (rds) mouse in the absence of an increase in hematocrit and to determine if deglycosylated EPO (DEPO) is less neuroprotective...
  41. ncbi Erythropoietin improves mood and modulates the cognitive and neural processing of emotion 3 days post administration
    Kamilla Miskowiak
    Department of Experimental Psychology, University of Oxford, Oxford, UK
    Neuropsychopharmacology 33:611-8. 2008
    ..Consistent with our previous finding, Epo improved self-reported mood for all 3 days post-administration. Together, these results suggest that characterization of the effects of Epo in a clinically depressed group is warranted...
  42. ncbi A novel method utilising markers of altered erythropoiesis for the detection of recombinant human erythropoietin abuse in athletes
    R Parisotto
    Department of Physiology, Australian Institute of Sport, P O Box 176, Belconnen ACT 2616, Australia
    Haematologica 85:564-72. 2000
    ..Existing tests cannot readily differentiate between exogenous and endogenous EPO. Therefore the aim of our study was to investigate possible indirect detection of r-HuEPO use via blood markers of altered erythropoiesis...
  43. ncbi Effects of prolonged low doses of recombinant human erythropoietin during submaximal and maximal exercise
    Gabrielle Russell
    Department of Physiology, Australian Institute of Sport, Canberra, Australia
    Eur J Appl Physiol 86:442-9. 2002
    ..After 8 weeks of r-HuEPO use, plasma lactate concentration tended to be lower at exercise intensities ranging from 60% to 100%. This study confirmed the ability of low doses of r-HuEPO to maintain Hct and at elevated levels...
  44. ncbi Rheologic behavior of sickle and normal red blood cell mixtures in sickle plasma: implications for transfusion therapy
    Tamas Alexy
    Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Transfusion 46:912-8. 2006
    Guidelines for transfusion in sickle cell disease usually define an upper hematocrit (Hct) limit of 0.30 to 0.35 to avoid blood hyperviscosity...
  45. ncbi Association of single measurements of dipstick proteinuria, estimated glomerular filtration rate, and hematocrit with 25-year incidence of end-stage renal disease in the multiple risk factor intervention trial
    Areef Ishani
    Division of Nephrology 111J, Department of Medicine, Veterans Affairs Medical Center, One Veterans Drive, Minneapolis, MN 55417, USA
    J Am Soc Nephrol 17:1444-52. 2006
    ..study aimed to determine over 25 yr the risk for ESRD associated with proteinuria, estimated GFR (eGFR), and hematocrit in men who did not have identified kidney disease and were randomly assigned into the Multiple Risk Factor ..
  46. ncbi Neocytolysis on descent from altitude: a newly recognized mechanism for the control of red cell mass
    L Rice
    Section of Hematology, Department of Medicine, Baylor College of Medicine, 6565 Fannin, MS 902 Main, Houston, TX 77030, USA
    Ann Intern Med 134:652-6. 2001
    ..Studies of space-flight anemia have uncovered a physiologic process, neocytolysis, by which young red blood cells are selectively hemolyzed, allowing rapid adaptation when red cell mass is excessive for a new environment...
  47. ncbi Hematocrit and the risk of coronary heart disease mortality
    D W Brown
    Cardiovascular Health Branch, Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341-3717, USA
    Am Heart J 142:657-63. 2001
    BACKGROUND: An association between hematocrit (Hct) and coronary heart disease (CHD) mortality has been previously observed...
  48. ncbi Elevated hematocrit is associated with reduced reperfusion and tissue survival in acute stroke
    L E Allport
    Department of Neurology, Royal Melbourne Hospital, University of Melbourne, Parkville Victoria, Australia
    Neurology 65:1382-7. 2005
    Elevated hematocrit (Hct) contributes to blood viscosity and has an adverse effect in acute stroke. The authors investigated the influence of Hct on tissue fate using serial MRI in acute stroke patients.
  49. pmc Erythropoietin therapy for acute stroke is both safe and beneficial
    Hannelore Ehrenreich
    Max Planck Institute for Experimental Medicine, Departments of Neurology and Psychiatry, Georg August University, Goettingen, Germany
    Mol Med 8:495-505. 2002
    ..EPO protects neurons from hypoxic/ ischemic injury. The objective of this trial is to study the safety and efficacy of recombinant human EPO (rhEPO) for treatment of ischemic stroke in man...
  50. ncbi Association of quarterly average achieved hematocrit with mortality in dialysis patients: a time-dependent comorbidity-adjusted model
    Joseph M Messana
    Division of Nephrology, University of Michigan Health System, Ann Arbor, MI 48109 5364, USA
    Am J Kidney Dis 53:503-12. 2009
    Recent publications suggest that increased mortality is associated with high hematocrit targets in erythropoietin-stimulating agent-treated patients with chronic kidney disease...
  51. ncbi Blood volume and hemoglobin mass in elite athletes of different disciplines
    K Heinicke
    Department of Sports Medicine, University of Bayreuth, Germany
    Int J Sports Med 22:504-12. 2001
    ..The reasons for the different BVs are an increased adaptation to training stimuli and probably also individual predisposing genetic factors...
  52. ncbi Elevated capillary tube hematocrit reflects degradation of endothelial cell glycocalyx by oxidized LDL
    A A Constantinescu
    Department of Medical Physics, University of Amsterdam, 1100 DE Amsterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 280:H1051-7. 2001
    ..endothelial cell glycocalyx are essential for vascular function, but at the same time, they lower capillary tube hematocrit by reducing capillary volume available to flowing blood...
  53. ncbi Low hematocrit during cardiopulmonary bypass is associated with increased risk of perioperative stroke in cardiac surgery
    Keyvan Karkouti
    Department of Anesthesia, University Health Network, Toronto, Ontario, Canada
    Ann Thorac Surg 80:1381-7. 2005
    ..The objective of this observational study was to evaluate the relationship between nadir hematocrit during CPB and perioperative stroke while adjusting for variables known to have an association with stroke and ..
  54. pmc Sustained pulmonary hypertension and right ventricular hypertrophy after chronic hypoxia in mice with congenital deficiency of nitric oxide synthase 3
    W Steudel
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Invest 101:2468-77. 1998
    ....
  55. ncbi The role of the kidney in blood volume regulation: the kidney as a regulator of the hematocrit
    A Dunn
    Department of Medicine, St Michael s Hospital, University of Toronto, Ontario, Canada
    Am J Med Sci 334:65-71. 2007
    ..that the kidney coordinates the relative volumes of these 2 blood components and in so doing regulates the hematocrit. This novel function as proposed is a functional concept whereby the kidney does not simply produce ..
  56. ncbi Epoetin alfa increases frataxin production in Friedreich's ataxia without affecting hematocrit
    Francesco Saccà
    Department of Neurological Sciences, University Federico II, Napoli, NA, Italy
    Mov Disord 26:739-42. 2011
    ..001). The treatment was well tolerated and did not affect hematocrit, cardiac function, and neurological scale...
  57. ncbi Excessive erythrocytosis in adult mice overexpressing erythropoietin leads to hepatic, renal, neuronal, and muscular degeneration
    Katja Heinicke
    Institute of Veterinary Physiology, Vetsuisse Faculty and Zurich Center for Integrative Human Physiology ZIHP, Switzerland
    Am J Physiol Regul Integr Comp Physiol 291:R947-56. 2006
    ..tg6) that constitutively overexpresses erythropoietin (Epo) in a hypoxia-independent manner, thereby reaching hematocrit levels of up to 0.89...
  58. ncbi Oxygenation and hematocrit dependence of transverse relaxation rates of blood at 3T
    Jason M Zhao
    Department of Radiology, Division of MRI Research, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Magn Reson Med 58:592-7. 2007
    ..When including extravascular effects to estimate the total BOLD effect, GRE BOLD dominated due to the large tissue volume fraction...
  59. ncbi Immune status of free-ranging green turtles with fibropapillomatosis from Hawaii
    T M Work
    US Geological Survey, National Wildlife Health Center, Honolulu Field Station, Hawaii 96850, USA
    J Wildl Dis 37:574-81. 2001
    ..Blood was assayed for differential white blood cell count, hematocrit, in vitro peripheral blood mononuclear cell (PBMC) proliferation in the presence of concanavalin A (ConA) and ..
  60. pmc Comparisons of vegetarian and beef-containing diets on hematological indexes and iron stores during a period of resistive training in older men
    Amanda M Wells
    General Clinical Research Center, University of Arkansas for Medical Sciences, Little Rock, USA
    J Am Diet Assoc 103:594-601. 2003
    ..To test the hypothesis that older men who consumed a vegetarian (lacto-ovo) diet would develop a lower iron status compared with older men who consumed a beef-containing diet during a period of resistive training (RT)...
  61. ncbi Magnetic resonance microscopy determined velocity and hematocrit distributions in a Couette viscometer
    Giles R Cokelet
    Department of Chemical and Biological Engineering, Montana State University, Bozeman, MT 59175 3920, USA
    Biorheology 42:385-99. 2005
    ..The spatial distribution of the red blood cell volume fraction, hematocrit, is calculated from the velocity distribution...
  62. ncbi Cognitive impairment in children with hemoglobin SS sickle cell disease: relationship to MR imaging findings and hematocrit
    R Grant Steen
    Department of Diagnostic Imaging, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    AJNR Am J Neuroradiol 24:382-9. 2003
    ..We test a hypothesis that cognitive impairment in children with hemoglobin SS sickle cell disease is associated with low hematocrit and MR imaging abnormalities.
  63. ncbi Correlation of transfusion volume to change in hematocrit
    Mark E Elzik
    University of North Carolina Chapel Hill, Chapel Hill, North Carolina, USA
    Am J Hematol 81:145-6. 2006
    While it has generally been accepted that a 3% change in hematocrit is equivalent to a 1-"unit" loss of blood, few studies have been published to actually document this...
  64. pmc Decreased hematocrit-to-viscosity ratio and increased lactate dehydrogenase level in patients with sickle cell anemia and recurrent leg ulcers
    Philippe Connes
    UMR Inserm 665, Universite des Antilles et de la Guyane, Pointe a Pitre, Guadeloupe Laboratory of Excellence GR Ex The red cell from genesis to death, PRES Sorbonne Paris Cité, Paris, France Laboratoire ACTES EA 3596 Département de Physiologie, Universite des Antilles et de la Guyane, Pointe a Pitre, Guadeloupe
    PLoS ONE 8:e79680. 2013
    ..The hematocrit-to-viscosity ratio (HVR), which reflects the red blood cell oxygen transport efficiency, was calculated for each ..
  65. ncbi Prediction of anemia on unenhanced computed tomography of the thorax
    Michelle Foster
    Department of Radiology, Kingston General Hospital
    Can Assoc Radiol J 54:26-30. 2003
    ..To determine if anemia can be predicted on unenhanced computed tomography (CT) of the thorax...
  66. pmc Estimates of total analytical error in consumer and hospital glucose meters contributed by hematocrit, maltose, and ascorbate
    Martha E Lyon
    Department of Pathology and Laboratory Medicine, University of Calgary, and Alberta Children s Hospital, Calgary, Alberta, Canada
    J Diabetes Sci Technol 4:1479-94. 2010
    ..The objective of this study was to estimate analytical error in two consumer and two hospital glucose meters contributed by variations in hematocrit, maltose, ascorbate, and imprecision.
  67. ncbi The effect of hematocrit on assay bias when using DBS samples for the quantitative bioanalysis of drugs
    Philip Denniff
    Platform Technology and Science, Drug Metabolism and Pharmacokinetics, GlaxoSmithKline Research and Development, Ware, Hertfordshire, SG12 0DP, UK
    Bioanalysis 2:1385-95. 2010
    As hematocrit levels are known to vary between individuals and with disease state, its effect on the physical characteristics of dried blood spot (DBS) samples and on the accurate quantification of analytes within these samples is examined...
  68. ncbi The impact of fluid restriction policy in reducing the use of red blood cells in cardiac surgery
    G Vretzakis
    Cardiac Anesthesia Unit, Department of Anesthesiology, University Hospital of Larissa, Greece
    Acta Anaesthesiol Belg 60:221-8. 2009
    ..0001). In both groups, the values of hematocrit were statistically decreased...
  69. ncbi Homocysteine and pulsatility index in lacunar infarction
    Seul Ki Jeong
    Department of Neurology, Chonbuk National University Medical School and Hospital, Jeonju, Jeonbuk, South Korea
    Clin Neurol Neurosurg 113:459-63. 2011
    ..To evaluate an association between plasma concentration of total homocysteine (tHcy) and pulsatility indexes (PIs) of cerebral arteries in patients with lacunar infarction (LI), comparing control subjects...
  70. ncbi Effect on routine and special coagulation testing values of citrate anticoagulant adjustment in patients with high hematocrit values
    Richard A Marlar
    Pathology and Laboratory Medicine Service, Oklahoma, City Veterans Affairs Medical Center, Oklahoma City, OK 73104, USA
    Am J Clin Pathol 126:400-5. 2006
    Recommendations to adjust citrate concentration for blood coagulation specimens with high hematocrit values are based on indirect experimental studies and not direct studies of patient samples with high hematocrit values...
  71. ncbi Pre-cut dried blood spot (PCDBS): an alternative to dried blood spot (DBS) technique to overcome hematocrit impact
    Nikolay Youhnovski
    Algorithme Pharma Inc, 575 Armand Frappier, Laval, Quebec, Canada, H7V 4B3
    Rapid Commun Mass Spectrom 25:2951-8. 2011
    ..However, some factors limit the robustness of the precision and accuracy of DBS such as: hematocrit level, blood viscosity, analyte nature, spotting technique and spotting conditions...
  72. ncbi The effect of hematocrit and punch location on assay bias during quantitative bioanalysis of dried blood spot samples
    M O'Mara
    Platform Technology and Science Drug Metabolism and Pharmacokinetics, GlaxoSmithKline Research and Development, Research Triangle Park, North Carolina, USA
    Bioanalysis 3:2335-47. 2011
    ..The aim of this investigation was to evaluate the impact of sample hematocrit (HCT) and punch location on assay bias in the measurement of compounds with varying physicochemical properties, ..
  73. ncbi Spatio-temporal variations in cell-free layer formation near bifurcations of small arterioles
    Peng Kai Ong
    Department of Bioengineering and Department of Surgery, National University of Singapore, Singapore
    Microvasc Res 83:118-25. 2012
    ..These findings confirmed the modulation of the cell-free layer formation near an arteriolar bifurcation, implicated by flow separation at the bifurcation...
  74. ncbi Multiple red blood cell flows through microvascular bifurcations: cell free layer, cell trajectory, and hematocrit separation
    Xuewen Yin
    Bharti School of Engineering, Laurentian University, Sudbury, ON P3E 2C6, Canada
    Microvasc Res 89:47-56. 2013
    ..The cell free layer (CFL), the RBC separation process and trajectories, and the resulting hematocrit distributions in the daughter branches have been examined, and the effects of cell deformability, aggregation, ..
  75. ncbi Reference ranges for hematocrit and blood hemoglobin concentration during the neonatal period: data from a multihospital health care system
    Jeffery Jopling
    Department of Women and Newborns, Intermountain Healthcare, Salt Lake City, Utah, USA
    Pediatrics 123:e333-7. 2009
    ..Reference ranges for the hematocrit and the blood hemoglobin concentration of newborn infants have previously been reported from relatively small ..
  76. ncbi High viscosity plasma expanders: Volume restitution fluids for lowering the transfusion trigger
    A G Tsai
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0412, USA
    Biorheology 38:229-37. 2001
    ..FCD is maintained as hematocrit is reduced beyond the transfusion trigger by increasing plasma viscosity, which transmits systemic pressure to ..
  77. ncbi The effect of N-acetylcysteine supplementation upon viral load, CD4, CD8, total lymphocyte count and hematocrit in individuals undergoing antiretroviral treatment
    Celso Spada
    UFSC Clinical Analysis Department, Centro de Ciencias da Saude, Universidade Federal de Santa Catarina, Florianopolis, Brazil
    Clin Chem Lab Med 40:452-5. 2002
    ..The aim of this study was to assess the serum viral load, CD4, CD8, lymphocyte count and hematocrit at the beginning of antiretroviral therapy in individuals who were supplemented with N-acetylcysteine (NAC)...
  78. ncbi Evaluation of acquired platelet dysfunctions in uremic and cirrhotic patients using the platelet function analyzer (PFA-100 ): influence of hematocrit elevation
    G Escolar
    Servicio de Hemoterapia y Hemostasia, Hospital Clinic, Villarroel 170, Barcelona 08036, Spain
    Haematologica 84:614-9. 1999
    ..The impact of low hematocrit was also analyzed.
  79. ncbi Hematocrit, systolic blood pressure and heart rate are not accurate predictors for surgery to control hemorrhage in injured patients
    Razvan C Opreanu
    Department of Surgery, College of Human Medicine, Michigan State University, Lansing, Michigan, USA
    Am Surg 76:296-301. 2010
    b>Hematocrit (Hct), systolic blood pressure (SBP), and heart rate (HR) are considered to closely correlate with hypovolemia in injured patients...
  80. pmc Serum alanine aminotransferase levels, hematocrit rate and body weight correlations before and after hemodialysis session
    Edmundo Pessoa Lopes
    Department of Medicine, Universidade Federal de Pernambuco UFPE, Recife, PE, Brazil
    Clinics (Sao Paulo) 64:941-5. 2009
    To evaluate alanine aminotransferase levels before and after a hemodialysis session and to correlate these values with the hematocrit rate and weight loss during hemodialysis.
  81. pmc Lowest hematocrit on cardiopulmonary bypass impairs the outcome in coronary surgery: An Italian Multicenter Study from the National Cardioanesthesia Database
    Marco Ranucci
    Istituto Policlinico S Donato, 20097 San Donato Milanese Milan, Italy
    Tex Heart Inst J 33:300-5. 2006
    ..The present study focuses on the lowest hematocrit values during extracorporeal circulation and on allogenic blood transfusions as mortality and morbidity risk ..
  82. ncbi Blood pressure directly correlates with blood viscosity in diabetes type 1 children but not in normals
    Beatriz Y Salazar Vázquez
    Faculty of Medicine, Universidad Juarez del Estado de Durango, Durango, Dgo, Mexico
    Clin Hemorheol Microcirc 44:55-61. 2010
    ..To determine the relationship between mean arterial blood pressure (MAP) and blood viscosity in diabetic type 1 children and healthy controls to investigate whether MAP is independent of blood viscosity in healthy children, and vice versa...
  83. ncbi A retrospective study on 226 polycythemia vera patients: impact of median hematocrit value on clinical outcomes and survival improvement with anti-thrombotic prophylaxis and non-alkylating drugs
    Elena Crisà
    Divisione di Ematologia dell Universita di Torino, Azienda Ospedaliera S Giovanni Battista di Torino, Via Genova 3, 10126 Turin, Italy
    Ann Hematol 89:691-9. 2010
    ..In particular, the recommended target of hematocrit (Hct) <0.45 has been recently questioned and alkylating drugs are still used for elderly patients...
  84. pmc Polycystic kidney disease in patients on the renal transplant waiting list: trends in hematocrit and survival
    Kevin C Abbott
    Nephrology Service, Walter Reed Army Medical Center, Washington, DC, USA
    BMC Nephrol 3:7. 2002
    ..The patient characteristics and mortality associated with autosomal dominant polycystic kidney disease (PKD) have not been characterized for a national sample of end stage renal disease (ESRD) patients on the renal transplant waiting list...
  85. ncbi A mouse model for an erythropoietin-deficiency anemia
    Brandon M Zeigler
    Department of Inflammation, Pfizer Global Research and Development, 700 West Chesterfield Parkway, St Louis, MO 63017, USA
    Dis Model Mech 3:763-72. 2010
    ..Taken together, these results demonstrate that this model can serve as a valuable preclinical model for the anemia of EPO deficiency, as well as a tool for the study of stress-induced erythropoiesis during limiting conditions of EPO...
  86. ncbi Cardiopulmonary bypass in humans--jejunal mucosal perfusion increases in parallel with well-maintained microvascular hematocrit
    A Thoren
    Department of Cardiothoracic Anesthesia and Intensive Care, Sahlgrenska University Hospital, Goteborg, Sweden
    Acta Anaesthesiol Scand 49:502-9. 2005
    ..Additionally we aimed to identify variables, which independently could predict changes of intestinal mucosal microcirculatory variables during CPB...
  87. ncbi Hematocrit influences immunoassay performance for the measurement of tacrolimus in whole blood
    Yolanda Armendariz
    Biochemistry Service, IDIBELL, Bellvitge Universitary Hospital, University of Barcelona, Spain
    Ther Drug Monit 27:766-9. 2005
    The comparison between the MEIA II and the EMIT assays for tacrolimus measurement and the interference by the hematocrit were evaluated in 93 samples from routine therapeutic monitoring at tacrolimus concentrations less than 9 microg/L (..
  88. pmc The relationship between maternal hematocrit and pregnancy outcome: black-white differences
    M L Blankson
    Division of Maternal and Child Health, School of Public Health, University of Alabama, Birmingham 35294
    J Natl Med Assoc 85:130-4. 1993
    Racial differences in hematocrit levels and the relationship between low and high hematocrit, intrauterine growth retardation, and preterm delivery were studied in a population of 17,149 low-income, iron- and folate-supplemented pregnant ..
  89. ncbi Anemia due to losartan in hypertensive renal transplant recipients without posttransplant erythrocytosis
    A Ersoy
    Department of Nephrology, Uludag University Medical School, 16059 Gorukle Bursa, Turkey
    Transplant Proc 37:2148-50. 2005
    ..Starting from week 6 and continuing to the week 12 we observed a decrease in hemoglobin (Hb) and hematocrit (Hct) levels in patients without PTE. Anemia developed in 42...
  90. pmc Role of 20-HETE in the pial arteriolar constrictor response to decreased hematocrit after exchange transfusion of cell-free polymeric hemoglobin
    Xinyue Qin
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Appl Physiol 100:336-42. 2006
    The cerebrovascular response to decreases in hematocrit and viscosity depends on accompanying changes in arterial O2 content...
  91. pmc Optimal hematocrit for maximal exercise performance in acute and chronic erythropoietin-treated mice
    Beat Schuler
    Institute of Veterinary Physiology, Vetsuisse Faculty and Zurich Center for Integrative Human Physiology, University of Zurich, 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 107:419-23. 2010
    Erythropoietin (Epo) treatment increases hematocrit (Htc) and, consequently, arterial O(2) content. This in turn improves exercise performance...
  92. ncbi Computational modeling of HHH therapy and impact of blood pressure and hematocrit
    Joe Sam Robinson
    Medical Center of Central Georgia, Macon, Georgia, USA
    World Neurosurg 74:294-6. 2010
    ..The objective of this study is to investigate, with a computational model, how various degrees of vasospasm are influenced by increasing the mean blood pressure and decreasing the blood viscosity...
  93. ncbi Evaluating the 'next generation' of cell salvage--will it make a difference?
    Gemma Yarham
    Department of Clinical Perfusion Science, Essex Cardiothoracic Centre, Nethermayne, Essex, UK
    Perfusion 26:263-70. 2011
    ..It is also the first to be launched in a new era where the demand for electronic perfusion data management (EPDM) has grown...
  94. ncbi Effect of hematocrit on pharmacokinetics of tacrolimus in adult living donor liver transplant recipients
    T Minematsu
    Department of Pharmacy, University of Tokyo Hospital, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Transplant Proc 36:1506-11. 2004
    ..Because FK506 highly and saturably binds in blood cells, a change in hematocrit value (Hct) may affect FK506 pharmacokinetics...
  95. ncbi The prolonged half-lives of new erythropoietin derivatives via peptide addition
    Dong Eok Lee
    Biomedical Research Center, Department of Biological Science, Korea Advanced Institute of Science and Technology, Taejon 305 701, Republic of Korea
    Biochem Biophys Res Commun 339:380-5. 2006
    ..Therefore, these derivatives with prolonged half-lives may provide opportunities for developing new Epo therapeutics with less frequent administration...
  96. ncbi The hematocrit paradox--how does blood doping really work?
    D Boning
    Sportmedizin, Charite Universitatsmedizin Berlin, Germany
    Int J Sports Med 32:242-6. 2011
    ..erythropoietin or blood transfusion is only effective by increasing arterial blood O2 content because of rising hematocrit is not self-evident...
  97. ncbi Relationship between haemoglobin and haematocrit in the definition of anaemia
    Llorenç Quintó
    Centre de Salut Internacional, CSI, Hospital Clinic IDIBAPS, Universitat de Barcelona, Barcelona, Spain
    Trop Med Int Health 11:1295-302. 2006
    ..Haematocrit (Hct) (%) is usually defined as three times the value of haemoglobin (Hgb) (g/dl), while the clinical definition of anaemia is related to either an abnormal Hct or Hgb value...
  98. ncbi Volume assessment in patients with necrotizing pancreatitis: a comparison of intrathoracic blood volume index, central venous pressure, and hematocrit, and their correlation to cardiac index and extravascular lung water index
    Wolfgang Huber
    II Medizinische Klinik, Klinikum Rechts der Isar Technische Universität, Munchen, Germany
    Crit Care Med 36:2348-54. 2008
    Volume depletion and/or increased hematocrit are associated with poor prognosis in necrotizing pancreatitis...
  99. ncbi Normalization of hematocrit in hemodialysis patients with cardiac disease does not increase blood pressure
    P J Conlon
    Department of Medicine, Duke University, Medical Center, Durham, NC 27710, USA
    Ren Fail 22:435-44. 2000
    ..We undertook this study to determine if the correction of anemia in ESRD patients with cardiac disease from a hematocrit of 30+/-3% to 42+/-3% with the use of Epoetin alfa would result in increased blood pressure...
  100. ncbi Critical hematocrit in intestinal tissue oxygenation during severe normovolemic hemodilution
    - van Bommel J
    Department of Anesthesiology, Academic Medical Center, University of Amsterdam, The Netherlands
    Anesthesiology 94:152-60. 2001
    ..The present study was designed to determine the systemic hematocrit and organ DO2 values below which organ microPO2 and VO2 cannot be preserved by regulatory mechanisms during ..
  101. ncbi Retinal vessel diameters in relation to hematocrit variation during acclimatization of highlanders to sea level altitude
    Peter Kristian Kofoed
    Department of Ophthalmology, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark
    Invest Ophthalmol Vis Sci 50:3960-3. 2009
    ..To examine variations in retinal vessel diameters during acclimatization of native highlanders to normobaric normoxia at sea level...

Research Grants62

  1. Impact of Seasonal Variation in Hematocrit, NOx & ET-1 on Vascular Reactivity
    Deidre Wipke Tevis; Fiscal Year: 2009
    ..Preliminary data in healthy men suggest that hematocrit (Hct, a determinant of blood viscosity) peaks while plasma nitrite/nitrate (NOx, a stable metabolite of the ..
  2. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  3. Infant Screening and Diagnosis of Duchenne Muscular Dys*
    Paul Fernhoff; Fiscal Year: 2007
    ..Furthermore, the applicant notes that at the second planned visit a finger stick is performed to determine hematocrit, thus allowing an easy opportunity to collect another drop of blood for the DMD screening...
  4. VEGF Regulation of Hepatic Erythropoietin Synthesis
    Calvin Kuo; Fiscal Year: 2009
    ..soluble VEGF receptors, or sVEGFRs) in normal mice strongly stimulates erythropoiesis, with increase in hematocrit increasing from baseline 45% to new levels of 55-75 %...
  5. Predicting persistent Organ Failure early in Acute Pancreatitis
    Georgios I Papachristou; Fiscal Year: 2013
    ..Using data from this same cohort, we will calculate the accuracy of 5 single markers (glucose, hematocrit, blood urea nitrogen, creatinine, and C-reactive protein) and 7 scoring systems (Ranson's, acute physiology ..
  6. Role of surface proteins in sand fly colonization by Bartonella bacilliformis
    Michael F Minnick; Fiscal Year: 2013
    ..In non-endemic regions, the disease manifests as an acute illness with an ~80% reduction in erythrocyte hematocrit (Oroya fever), whereas in endemic regions, angiomatous skin lesions (verruga peruana) and chronic bacteremia ..
  7. Peptide Therapy for Pulmonary Arterial Hypertension
    Jawaharlal M Patel; Fiscal Year: 2013
    ..progressive and regressive pulmonary hemodynamic modulations (increased PAP, SAP, cardiac output/cardiac index, hematocrit, and RV hypertrophy) and vascular remodeling associated with PH as well as toxicity...
  8. CYP19A1 gene and Pharmacogenetics of Response
    REINA C VILLAREAL; Fiscal Year: 2013
    ..Among the side effects described for testosterone therapy, prostate-related events and an increase in hematocrit represent as the more common and the potentially more serious side effects...
  9. Individualized Treatment Strategies and Optimal Hematocrit Target for Complex Dia
    DENNIS JOSEPH COTTER; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Individualized Patient Treatment Strategies and Optimal Hematocrit Target for the Complex Dialysis Patient Background...
  10. FOCUS
    JEFFREY LEE CARSON; Fiscal Year: 2011
    ..standard of care today to administer blood transfusions based on the presence of symptoms and not a specific Hgb/hematocrit level...
  11. Caring for Those Who Share: Mitigating Iron Deficiency in Regular Blood Donors
    Alan E Mast; Fiscal Year: 2013
    ..in successful collection of a unit of blood and how they change the proportion of donor visits resulting in low hematocrit deferral...
  12. Genetic Discovery and Application in a Clinical Setting Continuing a Partnership
    Eric B Larson; Fiscal Year: 2013
    ..A new algorithm will follow longitudinal glycemia and hematocrit trajectories, and a novel automated method will detect karyotype abnormalities for assessing correlation to ..
  13. In vivo function of macrophage in healthy and diseased erythropoiesis
    Paul S Frenette; Fiscal Year: 2013
    ..from transgenic overexpression of mutated JAK2V617F, we have found that M[unreadable] depletion normalized the hematocrit, suggesting that erythropoiesis in PV, unexpectedly, depends on signals from the microenvironment...
  14. FOCUS Data Coordinating Center
    Michael L Terrin; Fiscal Year: 2010
    ..of care to administer blood transfusions based on the presence of symptoms and not a specific hemoglobin/hematocrit level...
  15. Transfusion-Associated Brain Improvement (TABI) Trial: Data Coordinating Center
    Abhik Das; Fiscal Year: 2013
    ..practices and differences in dispensed products across multiple study sites and will adjust for variation in the hematocrit of dispensed RBCs by site...
  16. Impact of Blood Viscosity on Oxygen Delivery in humans with Sickle Cell Anemia
    THOMAS DUANE COATES; Fiscal Year: 2011
    ..Our preliminary data suggests that changes in HbS and hematocrit that improve arterial flow may be detrimental in low shear flow areas like the cerebral cortex and heart...
  17. Blood Transfusions: Gender Differences in Utilization, Predictors, and Outcomes
    Mary A M Rogers; Fiscal Year: 2010
    ..frequent in women than men since the criteria for prescribing a transfusion often rests with threshold levels of hematocrit or hemoglobin which are normally lower in women...
  18. PHOTOACOUSTIC MICROSCOPY OF NEOVASCULARIZATION IN RENAL CANCER GROWTH AND THERAPY
    JEFFREY MICHAEL ARBEIT; Fiscal Year: 2013
    ..PAM uses laser excitation of hemoglobin (Hb) to determine neovascular architecture, Hb concentration (hematocrit), oxygen saturation (SO2), and flow in each tumor microvessel at capillary level resolution without exogenous ..
  19. A Translational Approach to Heterogeneity of Pain in Pediatric Sickle Cell Anemia
    ALYSSA MARIE SCHLENZ; Fiscal Year: 2012
    ..Hematological factors, such as hematocrit and fetal hemoglobin, have been shown to predict the frequency of VOEs;however, it is likely that many ..
  20. Imaging the Mitochondrial Response to Neural Activity
    Roger J Springett; Fiscal Year: 2010
    ..based on a rapid Monte Carlo forward model, (iii) Develop methods to image total blood volume and tissue hematocrit and test the hypothesis that changes in the tissue hematocrit are insensitive to changes in the draining venules ..
  21. Optimizing Protein Intake in Older Americans with Mobility Limitations
    Shalendar Bhasin; Fiscal Year: 2013
    ..Safety measures include estimated GFR, urinary calcium excretion, hematocrit, PSA, and prostate examination...
  22. Aspirin-PC for Chemoprevention of Colorectal Cancer
    Lenard M Lichtenberger; Fiscal Year: 2013
    ..by inspecting the upper and lower gut macroscopically, microscopically and assess GI bleeding by measuring hematocrit and fecal hemoglobin...
  23. Physiologic effects of androgen and estrogen deficiency in young and old men
    Joel S Finkelstein; Fiscal Year: 2011
    ..Changes in strength, muscle size, BMD, sexual function, lipids, PSA, hematocrit, and symptoms will also be assessed...
  24. Disease States of Red Blood Cells in Vascular Microvessels
    PANAGIOTIS DIMITRAKOPOULOS; Fiscal Year: 2010
    ..Of particular interest is the variation of the volume fraction of RBCs (or hematocrit) and the changes in the blood apparent viscosity (i.e...
  25. Monitoring Brain Health in Neonatal Congenital Heart Disease with Bedside CMR02
    PATRICIA ELLEN GRANT; Fiscal Year: 2013
    ..amount of oxygen consumed by neurons, and is affected by multiple non-neuronal factors such as blood flow and hematocrit. In contrast, bedside frequency domain NIRS (FDNIRS) combined with diffuse correlation spectroscopy (DCS) ..
  26. STAT Palm-Sized Blood Counter
    EUGENE YAN HO CHAN; Fiscal Year: 2010
    ..For instance, a rapidly rising white blood cell count may occur during infections or leukemic blast crises. Hematocrit values may rapidly decline in traumas, gastrointestinal bleeds, and post-procedure recoveries...
  27. Blood flow and structural adaptation in microcirculation
    Timothy W Secomb; Fiscal Year: 2013
    ..ii) The partition of hematocrit in diverging bifurcations can be predicted based on the upstream distribution of cells and the effects of cell-..
  28. STAT Palm-Sized Blood Counter
    EUGENE YAN HO CHAN; Fiscal Year: 2013
    ..For instance, a rapidly rising white blood cell count may occur during infections or a leukemic blast crises. Hematocrit values may rapidly decline in traumas, gastrointestinal bleeds, and post- procedure recoveries...
  29. Functional Optical Coherence Tomography for Imaging of Cortical Hemodynamics
    VIVEK JAY SRINIVASAN; Fiscal Year: 2010
    ..technologies and methods to enhance the capability of OCT to quantitatively measure blood flow, blood volume, hematocrit, oxygen saturation, and capillary dilation...
  30. Erythropoiesis-stimulating agent use among chronic kidney disease patients
    DENNIS JOSEPH COTTER; Fiscal Year: 2012
    ..When to start ESA therapy - at what hematocrit level - and at what threshold level to maintain hematocrit throughout treatment is unknown...
  31. ESA Outcomes among Anemic CKD Patients
    DENNIS JOSEPH COTTER; Fiscal Year: 2013
    ..When to start ESA therapy - at what hematocrit level - and at what threshold level to maintain hematocrit throughout treatment is unknown...
  32. Functional Optical Coherence Tomography for Imaging of Cortical Hemodynamics
    VIVEK JAY SRINIVASAN; Fiscal Year: 2013
    ..technologies and methods to enhance the capability of OCT to quantitatively measure blood flow, blood volume, hematocrit, oxygen saturation, and capillary dilation...
  33. S-nitrosothiol analyzer for the clinical diagnosis of cardiovascular disease mark
    Michael R Pisano; Fiscal Year: 2011
    ..g. hematocrit/hemoglobin) will be determined in Phase I and will serve as the criteria to build and validate the prototype ..
  34. CONTROL OF HEMATOPOIETIC TOXICITY WITH INTERLEUKIN-1
    VINCENT GALLICCHIO; Fiscal Year: 1990
    ..will incorporate the ability of these agents to examine their effect on various peripheral blood indices (hematocrit, WBC, platelets and differential), while also examining the stem cell content in hematopoietic tissues (bone ..
  35. Quantitative Analysis of Blood Flow in Sickle Cell Disease
    JOHN MATTHEW HIGGINS; Fiscal Year: 2012
    ..Control parameters for vaso-occlusion include hemoglobin S concentration, oxygen tension, hematocrit, endothelial phenotype, vessel diameter, and pressure gradient...
  36. Complex Trait Analysis of Erythropoiesis in Normal Populations
    Luanne L Peters; Fiscal Year: 2011
    ..multiple baseline hematological parameters, including red blood cell (RBC) count, hemoglobin (Hgb) and hematocrit (Hct) levels, and mean corpuscular volume (MCV)...
  37. POLYMER-COATED RED BLOOD CELL FOR SICKLE CELL DISEASE
    TIMOTHY FISHER; Fiscal Year: 2003
    ..1) high alloimmunization rates (up to 30 percent) and iron accumulation; 2) limitation of post-transfusion hematocrit to less than 35 percent to avoid blood hyperviscosity which may precipitate a vaso-occlusive event...
  38. Adverse effects of RBC transfusions: A unifying hypothesis
    John D Roback; Fiscal Year: 2012
    ..Furthermore, a collection of other factors (reduced 2,3 DPG;endothelial dysfunction;elevated post-transfusion hematocrit levels) may further reduce NO bioavailability, leading to vasoconstriction, decreased blood flow, and reduced ..
  39. Quantitative MRI Assessment of Tumor Hypoxia and Angiogenesis
    CHRISTOPHER CHAD QUARLES; Fiscal Year: 2010
    ..We will evaluate and incorporate corrections for the influence of local tissue pH and hematocrit on these measurements and assess the usefulness of this method to track changes with therapy (Aim 1)...
  40. RISK SCORE FOR CORONARY ANEURYSMS IN KAWASAKI SYNDROME
    Jane Newburger; Fiscal Year: 1992
    ..white blood count, differential- white-cell count, absolute band count, absolute lymphocyte count, hemoglobin, hematocrit, platelet count, alpha-1-antitrypsin, albumin, and C-reactive protein...
  41. CLINICAL TRIAL OF HEMATOCRIT STRATEGY IN HEART SURGERY
    Jane Newburger; Fiscal Year: 2004
    ..Higher hematocrit (hct) exposes patients to the risks of microvascular occlusion, while lower hct may critically limit oxygen ..
  42. FETAL OXYGENATION AND GROWTH DURING MATERNAL ANEMIA
    DANIEL EDELSTONE; Fiscal Year: 1990
    ..To test our hypotheses, we will measures the effects of chronic reductions in maternal hematocrit on uterine blood flow, O2 delivery, O2 extraction, and O2 consumption as well as on umbilical blood flow and ..
  43. HEMORHEOLOGY IN SICKLE CELL ANEMIA AND RELATED DISORDERS
    HERBERT MEISELMAN; Fiscal Year: 1993
    ..studies will allow testing of the hypothesis that reduced SS cellular deformability affects viscosity, tube hematocrit and RBC transport efficiency in small tubes and will also serve to evaluate the usefulness of a model for the ..
  44. CHRONIC PSYCHOSOCIAL STRESS, METABOLIC SYNDROME, AND CHD
    Peter Vitaliano; Fiscal Year: 2001
    ..insulin, C-peptide, glucose), stress hormone (greater cortisol, catecholamines), plasma viscosity (greater hematocrit), and cardiovascular (greater blood pressure (BP) problems and higher rates of CHD relative to spouses of non-..
  45. Assessing Functional Outcomes in Adolescent with ESRD
    Susan Furth; Fiscal Year: 2002
    ..Furth to examine the link between clinical measures such as hematocrit, serum albumin, and dialysis adequacy (Kt/V) and functional outcome/HRQL...
  46. BLOOD FLOW IN THE DENERVATED ISCHEMIC REPERFUSED LIVER
    ANTHONY KOO; Fiscal Year: 1990
    ..In particular, we shall measure erthrocyte velocity and flux, and microcirculatory hematocrit in the liver sinusoid...
  47. LUNG CAPILLARY PERMEABILITY WITH HIGH VASCULAR PRESSURES
    Mary Townsley; Fiscal Year: 1991
    ..b>hematocrit fluid filtration volumes and lymphatic flux analysis...
  48. VIRUS PHOTOINACTIVATION--DIMETHYLMETHYLENE BLUE IN RBC
    Stephen Wagner; Fiscal Year: 2004
    ..methods to photoinactivate intracellular and extracellular viruses in red cell (RBC) suspensions of transfusable hematocrit under conditions that will neither harm the recipient nor the in vitro/in vivo properties of red cells...
  49. SEQUENTIAL ANALYSIS OF HEMATOLOGIC MEASUREMENTS
    Christine McLaren; Fiscal Year: 1992
    ..the detection and evaluation of anemia in hemodialysis patients by examination of the hemoglobin concentration, hematocrit, red cell count, mean corpuscular volume and red cell volume distribution...
  50. AGING AND COGNITION AFTER CARDIAC SURGERY
    Mark Newman; Fiscal Year: 2003
    ..It has become standard practice in cardiac surgery to allow the hematocrit advantages to blood flow during hypothermic cardiopulmonary bypass and fear of adverse consequences of ..
  51. Blood rheology, cell adhesion and endothelial activation
    Lance Munn; Fiscal Year: 2007
    ..For example, we previously found a 10-fold increase in the number of bound leukocytes when the hematocrit of the cell suspension in a flow chamber was increased from 0 to 30%...
  52. Painless Microsampling System for Total Hemoglobin and Hematocrit Monitoring
    Brian Sullivan; Fiscal Year: 2007
    ..Total hemoglobin and hematocrit are commonly used as markers for many conditions, including: anemia and polycythemia, dehydration, excessive ..
  53. Selective and Future Ignorability in Causal Inference
    Marshall M Joffe; Fiscal Year: 2013
    ..of interest is mismeasured;and 5) Use the methods developed to estimate the effect of erythropoietin use on hematocrit levels and mortality among subjects with end-stage renal disease receiving chronic hemodialysis, using data from ..
  54. EVENT RECORDINGS OF HIGH RISK INFANTS ON APNEA MONITORS
    DEBRA WEESE MAYER; Fiscal Year: 1991
    ..Baseline studies will include hematocrit, reticulocyte count, echocardiogram, cranial ultrasound, hair analysis for illicit drugs, growth parameters, and ..
  55. In Vivo Measurement of Myocardial Oxygen Consumption
    BRIGITTE PONCELET; Fiscal Year: 2004
    ..using radiolabeled microsphere injection (perfusion) and arterial/venous blood sampling (blood oxygenation and hematocrit) and Fick's Law...
  56. In Vivo Correlates of Altered Red Blood Cell Aggregation
    HERBERT MEISELMAN; Fiscal Year: 2004
    ..to blood flow; 2) to determine the effects of altered RBC aggregation on rat heart trans-mural myocardial hematocrit distribution to test the hypothesis that there is an optimal level of RBC aggregation which preserves the normal ..
  57. An Electrical Impedance Monitor
    Justin Clark; Fiscal Year: 2004
    Knowledge of Hematocrit (Hct) is important in several chronic and critical care situations. Presently, Hct measurement requires finger sticks, heel sticks, and blood withdrawals, causing patient trauma as a result of such blood sampling...
  58. Novel Modified Erythropoietins for the Treatment of Ischemic Brain Injury
    Guodong Cao; Fiscal Year: 2010
    ..Such an administration regimen of EPO may lead to increases in hematocrit and stimulate the production of platelets, increasing the likelihood of microinfarctions and macroinfarctions, ..
  59. EVALUATION OF DIAGNOSTIC CLINICAL HEMORRHEOLOGY
    GEOFFREY SEAMAN; Fiscal Year: 1980
    ..program is evaluating blood viscosity associated variables (apparent blood viscosity at various rates of shear, hematocrit, red cell deformability, fluidity and size, degree of cellular aggregation, plasma viscosity, serum protein ..
  60. NONINVASIC OPTICAL SENSOR FOR HEMOGLOBIN MEASUREMENTS
    LEONARD WINCHESTER; Fiscal Year: 1999
    ..of a noninvasive real-time blood sensor for the measurement of levels of four major hemoglobin moieties and hematocrit. The moieties to be measured are levels of oxyhemoglobin (O2Hb) reduced or deoxyhemoglobin (RHb), ..
  61. MEDICINE OR SURGERY?(MS?)
    Stephen Hulley; Fiscal Year: 2000
    ..For this study, abnormal bleeding is defined as more than eight days of menstrual flow per month or anemia (hematocrit <32 percent) in women with heavy flow and no other cause for anemia...