Genomes and Genes
Summary: Use of a thrombelastograph, which provides a continuous graphic record of the physical shape of a clot during fibrin formation and subsequent lysis.
Publications284 found, 100 shown here
- Diagnosis of early coagulation abnormalities in trauma patients by rotation thrombelastographyL Rugeri
Laboratory of Haemostasis, Edouard Herriot Hospital, Hospices Civils de Lyon and Claude Bernard University, Lyon, France
J Thromb Haemost 5:289-95. 2007Reagent-supported thromboelastometry with the rotation thrombelastography (e.g. ROTEM) is a whole blood assay that evaluates the visco-elastic properties during blood clot formation and clot lysis...
- Early evaluation of acute traumatic coagulopathy by thrombelastographyRoger C Carroll
Department of Anesthesiology, University of Tennessee Graduate School of Medicine, Knoxville, Tenn 37920, USA
Transl Res 154:34-9. 2009Posttraumatic coagulopathy is a major cause of morbidity. This prospective study evaluated the thrombelastography (TEG) system and PlateletMapping (Haemoscope Corporation, Niles, Ill) values posttrauma, and it correlated those values with ..
- Coagulation monitoring: current techniques and clinical use of viscoelastic point-of-care coagulation devicesMichael T Ganter
Department of Anesthesia and Perioperative Care, University of CA San Francisco, San Francisco, California, USA
Anesth Analg 106:1366-75. 2008..e., thrombelastography, rotation thrombelastometry, and Sonoclot analysis, may overcome several limitations of routine coagulation ..
- Rapid thrombelastography delivers real-time results that predict transfusion within 1 hour of admissionBryan A Cotton
Department of Surgery, The University of Texas Health Science Center, Houston, Texas 77030, USA
J Trauma 71:407-14; discussion 414-7. 2011..Rapid thrombelastography (r-TEG) delivers a more comprehensive assessment of the coagulation system but has not been prospectively ..
- Thrombelastography and biomarker profiles in acute coagulopathy of trauma: a prospective studySisse R Ostrowski
Section for Transfusion Medicine, Capital Region Blood Bank, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
Scand J Trauma Resusc Emerg Med 19:64. 2011Severe injury induces an acute coagulopathy associated with increased mortality. This study compared the Thrombelastography (TEG) and biomarker profiles upon admission in trauma patients.
- Primary fibrinolysis is integral in the pathogenesis of the acute coagulopathy of traumaJeffry L Kashuk
Division of Trauma, Acute Care, and Critical Care Surgery, Department of Surgery, Penn State Hershey Medical Center, College of Medicine, Hershey, PA 17033, USA
Ann Surg 252:434-42; discussion 443-4. 2010..Rapid thrombelastography (r-TEG) offers point of care comprehensive assessment of the coagulation system...
- Thrombelastography and tromboelastometry in assessing coagulopathy in traumaPär I Johansson
Regional Blood Bank, Rigshospitalet, University of Copenhagen, Denmark
Scand J Trauma Resusc Emerg Med 17:45. 2009....
- Transfusion in trauma: thromboelastometry-guided coagulation factor concentrate-based therapy versus standard fresh frozen plasma-based therapyHerbert Schöchl
Ludwig Boltzmann Institute of Experimental and Clinical Traumatology, Donaueschingenstrasse 13, A 1200 Vienna, Austria
Crit Care 15:R83. 2011....
- Goal-directed coagulation management of major trauma patients using thromboelastometry (ROTEM)-guided administration of fibrinogen concentrate and prothrombin complex concentrateHerbert Schöchl
Department of Anaesthesiology and Intensive Care, AUVA Trauma Hospital, Dr Franz Rehrl Platz 5, Salzburg, Austria
Crit Care 14:R55. 2010..The appropriate strategy for trauma-induced coagulopathy management is under debate. We report the treatment of major trauma using mainly coagulation factor concentrates...
- Normal range values for thromboelastography in healthy adult volunteersS Scarpelini
Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada
Braz J Med Biol Res 42:1210-7. 2009..Consideration should be given to a multi-institutional study to establish wide standard values for TEG...
- First-line therapy with coagulation factor concentrates combined with point-of-care coagulation testing is associated with decreased allogeneic blood transfusion in cardiovascular surgery: a retrospective, single-center cohort studyKlaus Görlinger
Klinik für Anästhesiologie und Intensivmedizin, Universitatsklinikum Essen, Essen, Germany
Anesthesiology 115:1179-91. 2011..We developed and implemented an algorithm for coagulation management in cardiovascular surgery based on first-line administration of coagulation factor concentrates combined with point-of-care thromboelastometry/impedance aggregometry...
- Functional characteristics of N8, a new recombinant FVIIIM L S Christiansen
Biopharmaceutical Research Unit, Novo Nordisk A S, Måløv, Denmark
Haemophilia 16:878-87. 2010..The study demonstrated that N8 is fully functional in a variety of assays measuring FVIII activity. No functional differences were found between N8 and comparator compounds...
- Rapidly degradable hydroxyethyl starch solutions impair blood coagulation after cardiac surgery: a prospective randomized trialAlexey A Schramko
Department of Anesthesiology and Intensive Care Medicine, Helsinki University Hospital, Meilahti Hospital, Helsinki, Finland
Anesth Analg 108:30-6. 2009..Because the risk of bleeding is increased after cardiopulmonary bypass, we examined whether these types of HES solutions could be administered after cardiac surgery without an alteration of coagulation...
- Global tests of haemostasis in critically ill patients with severe sepsis syndrome compared to controlsPeter W Collins
Department of Haematology, School of Medicine, Cardiff University and University Hospital of Wales, Cardiff, UK
Br J Haematol 135:220-7. 2006..005). In conclusion, global tests of haemostasis suggest that in this patient group, activation of haemostasis is delayed but once initiated thrombin generation and clot formation are normal or enhanced...
- Recovery of fibrinogen after administration of fibrinogen concentrate to patients with severe bleeding after cardiopulmonary bypass surgeryC Solomon
Department of Anaesthesiology and Intensive Care, Hannover Medical School, Carl Neuberg Str 1, D 30625 Hannover, Germany
Br J Anaesth 104:555-62. 2010..Data on transfusion and patient outcomes were also collected...
- Acute coagulopathy of trauma: balancing progressive catecholamine induced endothelial activation and damage by fluid phase anticoagulationP I Johansson
Section for Transfusion Medicine, Capital Region Blood Bank, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
Med Hypotheses 75:564-7. 2010..injury severity and the hemostatic response to trauma evaluated in whole blood by viscoelastic assays like thrombelastography (TEG), changing from normal to hypercoagulable, to hypocoagulable and finally hyperfibrinolytic in severely ..
- Hemostatic effects of fresh frozen plasma may be maximal at red cell ratios of 1:2Ross Davenport
Trauma Clinical Academic Unit, Blizard Institute of Cell and Molecular Science, The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
J Trauma 70:90-5; discussion 95-6. 2011..There is controversy over the optimal FFP:PRBC ratio with respect to outcomes, and their hemostatic effects have not been studied. We report preliminary findings on the effects of different FFP:PRBC ratios on coagulation...
- Hyperfibrinolysis after major trauma: differential diagnosis of lysis patterns and prognostic value of thrombelastometryHerbert Schöchl
Department of Anesthesiology and Intensive Care, AUVA Trauma Hospital, Salzburg, Austria
J Trauma 67:125-31. 2009..Furthermore, routine laboratory based and the rotational thrombelastometry analyzer (ROTEM)-derived variables were also correlated with survival...
- Thrombin generation assay and other universal tests for monitoring haemophilia therapyK Varadi
Baxter BioScience, Vienna, Austria
Haemophilia 10:17-21. 2004..coagulation (clotting time measurement) or the formation of a solidifying clot followed by fibrinolysis (thrombelastography), and excludes the real endpoint of thrombin generation...
- Prevalence and impact of abnormal ROTEM(R) assays in severe blunt trauma: results of the 'Diagnosis and Treatment of Trauma-Induced Coagulopathy (DIA-TRE-TIC) study'H Tauber
Clinic of Anaesthesiology and Intensive Care Medicine, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
Br J Anaesth 107:378-87. 2011..ROTEM(®)/TEG(®) (rotational thromboelastometry) assays appear to be useful for the treatment of bleeding trauma patients. However, data on the prevalence and impact of abnormal ROTEM(®) assays are scarce...
- Correlations between global clotting function tests, duration of operation, and postoperative chest tube drainage in pediatric cardiac surgeryTamaki Hayashi
Department of Pediatrics, Nara Medical University School of Medicine, Kashihara, Nara, Japan
Paediatr Anaesth 21:865-71. 2011..The aim of the present study was to investigate the relationship between postoperative hemorrhage and coagulation parameters determined by global coagulation assays, to define potential predictive markers...
- Comparison of thromboelastometry with procalcitonin, interleukin 6, and C-reactive protein as diagnostic tests for severe sepsis in critically ill adultsMichael Adamzik
Klinik für Anästhesiologie und Intensivmedizin, Universitätsklinikum Essen und Universität Duisburg Essen, Hufelandstr, 55, 45130 Essen, Germany
Crit Care 14:R178. 2010..We investigated whether thromboelastometry variables are suitable as biomarkers for severe sepsis in critically ill adults...
- Hydroxyethylstarch and gelatin solutions impair blood coagulation after cardiac surgery: a prospective randomized trialA Schramko
Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Hospital, Meilahti Hospital, Helsinki HUS, Finland
Br J Anaesth 104:691-7. 2010..Both hydroxyethylstarch (HES) and gelatin solutions impair haemostasis. We examined the impact and dose effect on coagulation of HES 130/0.4, gelatin, or Ringer's acetate solutions after cardiac surgery...
- The predictive value of modified computerized thromboelastography and platelet function analysis for postoperative blood loss in routine cardiac surgeryUrsula Cammerer
Department of Anesthesiology, German Heart Center, Munich, Germany
Anesth Analg 96:51-7, table of contents. 2003..Bleeding in these patients is probably caused surgically. The high negative predictive value supports early identification and targeted treatment of surgical bleeding by distinguishing it from a significant coagulopathy...
- Maize- or potato-derived hydroxyethyl starches: is there any thromboelastometric difference?A Godier
Paris Descartes University, INSERM U, Paris, France
Acta Anaesthesiol Scand 54:1241-7. 2010..This study compared the effects of a new potato-derived HES with a maize-derived HES and two crystalloid solutions...
- Does thromboelastography predict postoperative thromboembolic events? A systematic review of the literatureYue Dai
Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong, China
Anesth Analg 108:734-42. 2009..Therefore, we performed a systematic review of the literature to evaluate the accuracy of TEG in predicting postoperative thromboembolic events...
- Admission rapid thrombelastography predicts development of pulmonary embolism in trauma patientsBryan A Cotton
Department of Surgery, The University of Texas Health Science Center, Houston, Texas 77030, USA
J Trauma Acute Care Surg 72:1470-5; discussion 1475-7. 2012..A comprehensive assessment of these coagulation abnormalities can be measured and described by thrombelastography. The purpose of this study was to identify whether admission rapid-thrombelastography (r-TEG) could identify ..
- A thromboelastometric evaluation of the effects of hypothermia on the coagulation systemMalin Rundgren
Department of Anaesthesia and Intensive Care, Halmstad Central Hospital, Halmstad, Sweden
Anesth Analg 107:1465-8. 2008..Most studies have been performed on plasma instead of whole blood. We therefore evaluated whole blood investigating the effects of hypothermia on the coagulation system over a wide range of temperatures (25-40 degrees C)...
- Effects of albumin 5% and artificial colloids on clot formation in small infantsT Haas
Department of Anaesthesiology and Intensive Care Medicine, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
Anaesthesia 62:1000-7. 2007..4 solution. Standard coagulation tests and modified thrombelastography (ROTEM) were performed...
- Evaluation of prothrombin complex concentrate and recombinant activated factor VII to reverse rivaroxaban in a rabbit modelAnne Godier
Department of Anaesthesia and Critical Care, Paris Descartes University, Hotel Dieu University Hospital, Paris, France
Anesthesiology 116:94-102. 2012....
- The effect of the combined administration of colloids and lactated Ringer's solution on the coagulation system: an in vitro study using thrombelastograph coagulation analysis (ROTEGDietmar Fries
Department of Anesthesia and Intensive Care Medicine, The Leopold Franzens University of Innsbruck, Austria
Anesth Analg 94:1280-7, table of contents. 2002..We conclude that gelatin combined with 6% HES 200/0.5 or 6% HES 130/0.4 decreases hemostasis <6% HES 200/0.5 or 6% HES 130/0.4 administered alone...
- Coagulation monitoring of the bleeding traumatized patientPär I Johansson
Section for Transfusion Medicine, Regional Blood Bank, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Curr Opin Anaesthesiol 25:235-41. 2012..On admission, 25-35% of trauma patients present with coagulopathy, which is associated with a several-fold increase in morbidity and mortality...
- Application of thrombelastography/thromboelastometry to veterinary medicineAmir Kol
University of California, Davis, CA, USA
Vet Clin Pathol 39:405-16. 2010..b>Thrombelastography (TEG) detects and provides a continuous recording of the changes in the viscoelastic properties of whole ..
- Coagulation assessment by rotation thrombelastometry in normal pregnancyCyril Huissoud
Department of Obstetrics and Gynecology, Croix Rousse University Hospital, Lyon, Hospices Civils de Lyon, France
Thromb Haemost 101:755-61. 2009..ROTEM analysis showed a marked increase in coagulability during normal pregnancy. ROTEM values may serve as the basis for future studies in pregnant women...
- Can RapidTEG accelerate the search for coagulopathies in the patient with multiple injuries?Victor Jeger
Emergency Department, University Hospital Berne, Inselspital, Switzerland
J Trauma 66:1253-7. 2009Early recognition of coagulopathy may improve the care of patients with multiple injuries. Rapid thrombelastography (RapidTEG) is a new variant of thrombelastography (TEG), in which coagulation is initiated by the addition of protein ..
- Bedside assessment of fibrinogen level in postpartum haemorrhage by thrombelastometryC Huissoud
Department of Obstetrics and Gynecology, Croix Rousse University Hospital, Hospices Civils de Lyon, Lyon, France
BJOG 116:1097-102. 2009..To establish whether reagent-supported thrombelastometry with the rotation thrombelastometry system (ROTEM) point-of-care device correlated with fibrinogen level in postpartum haemorrhages...
- Thrombelastography in the surgical patientD Bischof
Institute of Anesthesiology, University Hospital Zurich, Switzerland
Minerva Anestesiol 76:131-7. 2010..Moreover, there is an important delay in obtaining test results. In contrast, thrombelastography and thrombelastometry, which both measure the visco-elastic properties of whole blood, allow the dynamic ..
- Perioperative coagulation monitoringSibylle A Kozek-Langenecker
Department of Anaesthesiology, General Intensive Care und Pain Management, Vienna Medical University, Wahringer Gurtel 18 20, 1090 Vienna, Austria
Best Pract Res Clin Anaesthesiol 24:27-40. 2010....
- An assessment of clinical interchangeability of TEG and RoTEM thromboelastographic variables in cardiac surgical patientsLieneke F Venema
Department of Anesthesiology, University Medical Centre Groningen, University of Groningen, P O Box 30 001, 9700 RB Groningen, The Netherlands
Anesth Analg 111:339-44. 2010..Bedside thromboelastography is increasingly used, but an assessment of the clinical interchangeability of the 2 major systems, TEG (Hemoscope) and RoTEM (Pentapharm), has not been performed...
- Diagnostic performance and therapeutic consequence of thromboelastometry activated by kaolin versus a panel of specific reagentsOle Halfdan Larsen
Centre for Haemophilia and Thrombosis, Aarhus University Hospital, Skejby, Denmark
Anesthesiology 115:294-302. 2011....
- Reduced clot strength upon admission, evaluated by thrombelastography (TEG), in trauma patients is independently associated with increased 30-day mortalityKristin B Nystrup
Department of Clinical Immunology, Section for Transfusion Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
Scand J Trauma Resusc Emerg Med 19:52. 2011..Thrombelastographic (TEG) clot strength has previously been shown to predict outcome in critically ill patients. The aim of the present study was to investigate this relation in the trauma setting...
- The role of rotation thromboelastometry in early prediction of massive transfusionHarald Leemann
Division of Surgery, Hospital Zug, Zug, Switzerland
J Trauma 69:1403-8; discussion 1408-9. 2010..Variables available early after injury including physiologic, laboratory, and rotation thromboelastometric (ROTEM) parameters were evaluated as predictors for the need of MT...
- Thromboelastometry-guided administration of fibrinogen concentrate for the treatment of excessive intraoperative bleeding in thoracoabdominal aortic aneurysm surgeryNiels Rahe-Meyer
Department of Anesthesiology, Hannover Medical School, Hannover, Germany
J Thorac Cardiovasc Surg 138:694-702. 2009..We assessed the efficacy of intraoperative post-cardiopulmonary bypass administration of fibrinogen concentrate in elective thoracoabdominal aortic aneurysm surgery...
- Differential clot stabilising effects of rFVIIa and rFXIII-A2 in whole blood from thrombocytopenic patients and healthy volunteersPär I Johansson
Department of Clinical Immunology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Br J Haematol 143:559-69. 2008..andrFXIII-A2 were evaluated in clot lysis assays using factor XIII-deficient plasma and by whole blood thrombelastography (TEG) analysis from normal donors and thrombocytopenic stem cell transplantation patients...
- Use of rotation thromboelastometry (ROTEM) to achieve successful treatment of polytrauma with fibrinogen concentrate and prothrombin complex concentrateH Schöchl
Department of Anaesthesiology and Critical Care Medicine, AUVA Trauma Centre, Salzburg, Austria
Anaesthesia 65:199-203. 2010..This case shows the potential success of treatment using both fibrinogen concentrate and prothrombin complex concentrate, not only in restoring haemostasis but also in minimising requirement for transfusion of allogeneic blood products...
- Postinjury coagulopathy management: goal directed resuscitation via POC thrombelastographyJeffry L Kashuk
Department of Surgery, Denver Health Medical Center, University of Colorado Denver, CO, USA
Ann Surg 251:604-14. 2010....
- Whole blood coagulation thrombelastographic profiles employing minimal tissue factor activationB Sørensen
Center for Haemophilia and Thrombosis, Department of Clinical Immunology, Aarhus University Hospital, Skejby, Denmark
J Thromb Haemost 1:551-8. 2003We investigated whole blood coagulation by thrombelastography (TEG) employing activation with minute amounts of tissue factor (TF)...
- The effects of glycosaminoglycans on coagulation: a thromboelastographic studyM Senzolo
Liver Transplantation and Hepatobiliary Unit, Royal Free Hospital, London, UK
Blood Coagul Fibrinolysis 18:227-36. 2007Endogenous heparinoids impair coagulation, evidenced by thrombelastography in cirrhotic patients with bacterial infection, but it is not clear which glycosaminoglycans can be detected by native and heparinase-modified thrombelastography...
- Hyperfibrinolysis diagnosed by rotational thromboelastometry (ROTEM) is associated with higher mortality in patients with severe traumaOliver M Theusinger
Institute of Anesthesiology, Clinic of Cardiac and Vascular Surgery, University Hospital Zurich, and Institute of Sockal and Preventive Medicine, University of Zurich, CH 8091 Zurich, Switzerland
Anesth Analg 113:1003-12. 2011..We investigated whether hyperfibrinolysis and its severity was associated with outcome of traumatized and nontraumatized patients...
- ThrombelastographyHakon Reikvam
Institute of Internal Medicine, Haukeland University Hospital, 5021 Bergen, Norway
Transfus Apher Sci 40:119-23. 2009..In the past decades there has been an increasing interest for TEG in clinical practice. In this paper we present the rationale for the method and a discussion of the possible application of TEG...
- Evaluation of human recombinant tissue factor-activated thromboelastography in 49 dogs with neoplasiaA T Kristensen
Department of Small Animal Clinical Sciences, The Faculty of Life Sciences, University of Copenhagen, Frederiksberg C, Denmark
J Vet Intern Med 22:140-7. 2008..Abnormal routine coagulation assay results have been reported to be common in veterinary patients with neoplasia, but the overall hemostatic functional state, including hypercoagulability, has not been described...
- Thromboelastometry for the assessment of coagulation abnormalities in early and established adult sepsis: a prospective cohort studyFritz Daudel
Department of Intensive Care Medicine, Inselspital, Bern University Hospital and University of Bern, Freiburgstrasse, 3010 Bern, Switzerland
Crit Care 13:R42. 2009..Using thromboelastometry (ROTEM(R)), we assessed the course of hemostatic alterations in patients with sepsis and related these alterations to the severity of organ dysfunction...
- Thromboelastographic evaluation of hemostatic function in dogs with disseminated intravascular coagulationB Wiinberg
Department of Small Animal Clinical Sciences, Faculty of Life Sciences, Small Animal Hospital, University of Copenhagen, Frederiksberg, Denmark
J Vet Intern Med 22:357-65. 2008..There is considerable variation in the coagulation profile of dogs with disseminated intravascular coagulation (DIC), making it difficult to assess overall hemostatic function...
- Tissue factor activated thromboelastography correlates to clinical signs of bleeding in dogsBo Wiinberg
The Small Animal Hospital, Department of Small Animal Clinical Sciences, Faculty of Life Sciences, University of Copenhagen, Frederiksberg DK 1870, Denmark
Vet J 179:121-9. 2009..The findings strongly suggest that TF- activated TEG may be of value in the workup of dogs suspected of having a haemostatic disorder...
- Hypocoagulability, as evaluated by thrombelastography, at admission to the ICU is associated with increased 30-day mortalityPär I Johansson
Department of Clinical Immunology, and Section for Transfusion Medicine, Capital Region Blood Bank, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Blood Coagul Fibrinolysis 21:168-74. 2010b>Thrombelastography (TEG), a cell-based whole blood assay, may better reflect haemostatic competence than conventional coagulation assays and this was therefore evaluated including the clot forming parameters: R, angle and maximal ..
- Transfusion triggers in orthotopic liver transplantation: a comparison of the thromboelastometry analyzer, the thromboelastogram, and conventional coagulation testsMargaret Coakley
Department of Anaesthesia, Royal Free Hospital, London, United Kingdom
J Cardiothorac Vasc Anesth 20:548-53. 2006....
- FIBTEM provides early prediction of massive transfusion in traumaHerbert Schöchl
Ludwig Boltzmann Institute for Experimental and Clinical Traumatology and AUVA Research Centre, Donaueschingenstraße 13, A 1200 Vienna, Austria
Crit Care 15:R265. 2011..Whole-blood thromboelastometry (ROTEM®) tests provide immediate information about the coagulation status of acute bleeding trauma patients. We investigated their value for early prediction of MT...
- Serotonergic mechanisms enhance platelet-mediated thrombogenicityAna M Galan
Servicio de Hemoterapia Hemostaia, Hospital Clinic, CDB, IDIBAPS, UB, 08036 Barcelona, Spain
Thromb Haemost 102:511-9. 2009..The remarkable antithrombotic actions achieved through SSRI deserve further mechanistic and clinical investigations...
- The influence of fibrin polymerization and platelet-mediated contractile forces on citrated whole blood thromboelastography profileTahar Chakroun
Service d Hematologie Biologique, Hotel Dieu de Paris, Paris, France
Thromb Haemost 95:822-8. 2006..Normal platelet contractile forces are of major importance for the maximum amplitude of TEG which is related to the strength and elastic modulus of the thrombus...
- Peculiar whole blood rotation thromboelastometry (Rotem) profile in 40 sideropenic anaemia patientsLuca Spiezia
Department of Cardia, Thoracic and Vascular Sciences, 2nd Chair of Internal Medicine, University of Padua Medical School, Via Ospedale 105, 35100 Padua, Italy
Thromb Haemost 100:1106-10. 2008....
- C-reactive protein and fibrin clot strength measured by thrombelastography after coronary stentingRolf P Kreutz
Krannert Institute of Cardiology, Indiana University School of Medicine, 1800 N Capitol Avenue, Indianapolis, IN 46202, USA
Blood Coagul Fibrinolysis 24:321-6. 2013..Heightened whole blood clot strength measured by thrombelastography (TEG) has been associated with adverse ischaemic events after stenting...
- The value of rotation thromboelastometry to monitor disturbed perioperative haemostasis and bleeding risk in patients with cardiopulmonary bypassMike Reinhöfer
Institute for Transfusion Medicine, Clinic for Anaesthesiology and Intensive Care Medicine, Division for Cardiothoracic Surgery, University Hospital Jena, Jena, Germany
Blood Coagul Fibrinolysis 19:212-9. 2008..In contrast, intraoperative administration of red blood cells impaired haemostasis. ROTEM can provide a more detailed diagnostic basis enabling a focused therapy to cardiac surgery patients with high bleeding risk...
- Admission rapid thrombelastography can replace conventional coagulation tests in the emergency department: experience with 1974 consecutive trauma patientsJohn B Holcomb
Center for Translational Injury Research, Division of Acute Care Surgery, Department of Surgery, Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
Ann Surg 256:476-86. 2012Injury and shock lead to alterations in conventional coagulation tests (CCTs). Recently, rapid thrombelastography (r-TEG) has become recognized as a comprehensive assessment of coagulation abnormalities...
- Hyperfibrinolysis at admission is an uncommon but highly lethal event associated with shock and prehospital fluid administrationBryan A Cotton
Department of Surgery, The University of Texas Health Science Center, Houston, Texas 77030, USA
J Trauma Acute Care Surg 73:365-70; discussion 370. 2012..To further strengthen this hypothesis, we created an in vitro hemodilution model to improve our mechanistic understanding of the early HF...
- Potential role of thrombelastography in the monitoring of acquired factor VIII inhibitor hemophilia A: report on a 78-year-old woman with life-threatening bleedingsLuca Spiezia
Department of Medical and Surgical Sciences, 2nd Chair of Internal Medicine, University of Padua Medical School, Via Ospedale 105, Padua, Italy
Clin Appl Thromb Hemost 15:470-6. 2009..ROTEM profile appears to be correlated with the response to treatment and with the eradication of the inhibitor...
- Thromboelastometry in patients with severe sepsis and disseminated intravascular coagulationMirka Sivula
Intensive Care Units, Department of Anesthesiology and Intensive Care Medicine, Helsinki University Hospital, Helsinki, Finland
Blood Coagul Fibrinolysis 20:419-26. 2009..We conclude that thromboelastometry may be a valuable tool in assessing whole blood coagulation capacity in patients with severe sepsis with and without overt DIC...
- Evaluation of coagulation stages of hemorrhaged swine: comparison of thromboelastography and rotational elastometryToshiki Tomori
Department of Trauma and Resuscitative Medicine, Naval Medical Research Center, Silver Spring, Maryland 20910 7500, USA
Blood Coagul Fibrinolysis 21:20-7. 2010..Both devices yielded similar information regarding the status of coagulation related to trauma. Because of operating characteristics, the same instrument should be used for monitoring the same patient or study...
- Thrombelastography versus AntiFactor Xa levels in the assessment of prophylactic-dose enoxaparin in critically ill patientsPhilbert Y Van
Division of Trauma and Critical Care, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
J Trauma 66:1509-15; discussion 1515-7. 2009..b>Thrombelastography (TEG) is used to evaluate coagulation in diverse settings...
- Reduced haemostatic factor transfusion using heparinase-modified thrombelastography during cardiopulmonary bypassD Royston
Department of Anaesthesia and Critical Care, Royal Brompton and Harefield NHS Trust, Harefield Hospital, Harefield, UK
Br J Anaesth 86:575-8. 2001....
- The prevalence of a heparin-like effect shown on the thromboelastograph in patients undergoing liver transplantationSeema Agarwal
Department of Anaesthesia, Royal Free Hospital, London, England
Liver Transpl 14:855-60. 2008..Although it is clear that there are both endogenous and exogenous sources of heparin contributing to the HLE, the clinical significance of these findings remains unclear...
- Hemodilution with albumin, but not Hextend, results in hypercoagulability as assessed by Thrombelastography in rabbits: role of heparin-dependent serpins and factor VIII complexAndrew T McCammon
Department of Anesthesiology, The University of Alabama at Birmingham, 35249, USA
Anesth Analg 95:844-50, table of contents. 2002..Antithrombin and Factor VIII complex (VIII:C) activities were determined, and thrombelastography(R) was performed with or without platelet inhibition. IVHD resulted in a significant (P < 0...
- Roles of thrombelastography and thromboelastometry for patient blood management in cardiac surgeryDaniel Bolliger
Department of Anesthesia and Intensive Care Medicine, University Hospital, Basel, Switzerland Electronic address
Transfus Med Rev 27:213-20. 2013The value of thrombelastography (TEG) and thromboelastometry (ROTEM) to improve perioperative hemostasis is under debate...
- Effects of coagulation factor deficiency on plasma coagulation kinetics determined via thrombelastography: critical roles of fibrinogen and factors II, VII, X and XIIV G Nielsen
Department of Anesthesiology, The University of Alabama at Birmingham, Birmingham, AL 35249 6810, USA vnielson uab edu
Acta Anaesthesiol Scand 49:222-31. 2005b>Thrombelastography (TEG) is used to assess coagulopathy. However, a comprehensive characterization of the effects of specific coagulation factor deficiencies and mode of activation on TEG data does not exist.
- The detection of changes in heparin activity in the rabbit: a comparison of anti-xa activity, thrombelastography, activated partial thromboplastin time, and activated coagulation timeVance G Nielsen
Department of Anesthesiology Divisions of Cardiothoracic Anesthesia and Anesthesiology Research, The University of Alabama at Birmingham, 35249, USA
Anesth Analg 95:1503-6, table of contents. 2002b>Thrombelastography (TEG) has been used to detect both exogenous and endogenous circulating heparin activity in clinical and laboratory settings...
- The influence of platelets, plasma and red blood cells on functional haemostatic assaysLouise Bochsen
Section for Transfusion Medicine, Capital Region Blood Bank, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Blood Coagul Fibrinolysis 22:167-75. 2011..and plasmatic elements, both isolated and combined, influenced the two methodologically different assays, thrombelastography (TEG) and impedance aggregometry (Multiplate)...
- Clot formation in canine whole blood as measured by rotational thromboelastometry is influenced by sample handling and coagulation activatorStephanie A Smith
Department of Biochemistry, College of Medicine, University of Illinois at Urbana Champaign, Urbana Champaign, Illinois 61801, USA
Blood Coagul Fibrinolysis 21:692-702. 2010....
- Point of care testing in children undergoing cardiopulmonary bypassTal Tirosh-Wagner
Department of Pediatrics of the Edmond and Lily Safra Children s Hospital, Affiliated to Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Pediatr Blood Cancer 56:794-8. 2011..The aim of this study was to define the potential role of the cone and platelet analyzer (CPA) and the rotating thromboelastogram (ROTEM) point of care tests in children undergoing CPB...
- Point-of-care testing in haemostasisDavid J Perry
Department of Haematology, Addenbrooke s Hospital, Cambridge, UK
Br J Haematol 150:501-14. 2010..bypass, platelet function testing to identify patients with apparent aspirin or clopidogrel resistance and thrombelastography to guide blood product replacement during cardiac and hepatic surgery...
- Early platelet dysfunction: an unrecognized role in the acute coagulopathy of traumaMax V Wohlauer
Department of Surgery, University of Colorado Denver, Denver, CO, USA
J Am Coll Surg 214:739-46. 2012..Although the current debate on acute traumatic coagulopathy has focused on the consumption or inhibition of coagulation factors, the question of early platelet dysfunction in this setting remains unclear...
- Redistribution and hemostatic action of recombinant activated factor VII associated with plateletsIrene Lopez-Vilchez
Hemotherapy and Hemostasis Service, Hospital Clinic, Biomedical Diagnostics Center CDB, Institute of Biomedical Research August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
Am J Pathol 178:2938-48. 2011..Redistribution of rFVIIa into platelets may explain the prolonged prophylactic effectiveness of rFVIIa in hemophilia...
- The impact of hematocrit on fibrin clot formation assessed by rotational thromboelastometrySatoru Ogawa
Department of Anesthesiology, Emory University School of Medicine, Atlanta, GA 30322, USA
Anesth Analg 115:16-21. 2012..Therefore, in the current study we investigated the influence of perioperative hematocrit changes on FIBTEM and fibrinogen measurements...
- Fast interpretation of thromboelastometry in non-cardiac surgery: reliability in patients with hypo-, normo-, and hypercoagulabilityK Görlinger
Klinik für Anästhesiologie und Intensivmedizin, Universitatsklinikum Essen, Universitat Duisburg Essen, Hufelandstrase 55, D 45122 Essen, Germany
Br J Anaesth 110:222-30. 2013..However, the reliability of early ROTEM(®) variables to predict maximum clot firmness (MCF) in non-cardiac surgery patients with subnormal, normal, and supranormal MCF has not yet been evaluated...
- Functional fibrinogen assay indicates that fibrinogen is critical in correcting abnormal clot strength following traumaJeffrey N Harr
Department of Surgery, University of Colorado Denver, Aurora, CO, USA
Shock 39:45-9. 2013..These data suggest that fibrinogen should be addressed early in trauma patients manifesting acute coagulopathy of trauma...
- Whole blood coagulation measured by modified thrombelastography (ROTEM) is impaired in infants with congenital heart diseasesWilhelm Alexander Osthaus
Anesthetic Center, Department of Pediatric Cardiology and Intensive Care, Medical University of Hannover, Germany
Blood Coagul Fibrinolysis 19:220-5. 2008..Our study aimed to determine the impact of cyanosis and CHD on modified thrombelastography parameters, compared with children without CHD...
- The role of rotational thromboelastometry in real time assessment of haemostasis in surgical settingsDragica Vucelic
Institute of Digestive System Diseases, Clinical Centre of Serbia, Belgrade, Serbia
Srp Arh Celok Lek 138:43-9. 2010..We describe the value of ROTEM in two haemostatically compromised patients...
- Intraoperative thromboelastometry is associated with reduced transfusion prevalence in pediatric cardiac surgeryBirgitta S Romlin
Department of Paediatric Anaesthesia and Intensive Care, Queen Silvia s Children Hospital, 416 85 Gothenburg, Sweden
Anesth Analg 112:30-6. 2011..We hypothesized that the routine use of intraoperative thromboelastometry to guide transfusion decisions would reduce the overall proportion of patients receiving transfusions in pediatric cardiac surgery...
- Fibrinogen concentrate reverses dilutional coagulopathy induced in vitro by saline but not by hydroxyethyl starch 6%Claudia De Lorenzo
Department of Anesthesiology, Ludwig Maximilians University, Munich, Germany
Anesth Analg 102:1194-200. 2006..Clot formation was measured by thrombelastography. At a 60% dilution, either fibrinogen and/or platelets were added to the samples...
- "Short" thrombelastography as a test of platelet reactivity in response to antiplatelet therapy: validation and reproducibilityNalyaka Sambu
Wessex Cardiothoracic Unit, Southampton University Hospital, UK
Platelets 22:210-6. 2011..Short Thrombelastography (s-TEG) is a validated test that allows rapid measurement of clotting responses to antiplatelet therapy.
- Detection of protamine and heparin after termination of cardiopulmonary bypass by thrombelastometry (ROTEM): results of a pilot studyMarkus Mittermayr
Department of Anesthesiology and Critical Care Medicine, Innsbruck Medical University, Anichstr 35, A 6020 Innsbruck, Austria
Anesth Analg 108:743-50. 2009..Our goal of this study was to determine whether protamine's effects on coagulation can be detected and differentiated from those of heparin when using thrombelastometry (ROTEM)...
- Artificial colloids impair haemostasis. An in vitro study using thromboelastometry coagulation analysisT T Niemi
Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Central Hospital, Helsinki, Finland
Acta Anaesthesiol Scand 49:373-8. 2005..Munich, Germany) in serial in vitro haemodilutions of colloids...
- In normal controls, both age and gender affect coagulability as measured by thrombelastographyWilfried W H Roeloffzen
Department of Hematology, University Medical Center Groningen, Groningen 9700 RB, The Netherlands
Anesth Analg 110:987-94. 2010Our objective was to analyze the effects of age, gender, and the use of oral contraceptives (OCs) on coagulation using thrombelastography (TEG), a single test to analyze both plasma coagulation factors and cellular elements in whole blood.
- Thromboelastography with citrated blood: comparability with native blood, stability of citrate storage and effect of repeated samplingAndrea Zambruni
Liver Transplantation and Hepatobiliary Medicine, Royal Free Hospital, London, UK
Blood Coagul Fibrinolysis 15:103-7. 2004..Thus, citrated blood can be used as a surrogate of native blood in assessing coagulation using TEG, but if repeated sampling is used the trend in hypercoagulability must be considered...
- Comparison of thrombelastometry with simplified acute physiology score II and sequential organ failure assessment scores for the prediction of 30-day survival: a cohort studyMichael Adamzik
Klinik für Anästhesiologie und Intensivmedizin, Universität Duisburg Essen and Universitätsklinikum Essen, Essen, Germany
Shock 35:339-42. 2011..01; odds ratio, 4.1), respectively, emphasizing the importance of the coagulation system in sepsis...
- Modified thromboelastography evaluation of platelet dysfunction in patients undergoing coronary artery surgerySergey Preisman
Department of Anesthesiology and Intensive Care, Sheba Medical Center, Tel Hashomer, Ramat Gan 52621, Tel Aviv University, Sackler School of Medicine, Tel Aviv, Israel
Eur J Cardiothorac Surg 37:1367-74. 2010..We investigated whether preoperative thromboelastography (TEG) with platelet mapping could predict bleeding tendency in patients (on recent anti-platelet therapy) undergoing coronary artery bypass grafting (CABG)...
- Reference values for kaolin-activated thromboelastography in healthy childrenKah Lok Chan
Department of Clinical Hematology, Royal Children s Hospital, Melbourne, Australia
Anesth Analg 105:1610-3, table of contents. 2007..In this study, we established reference values for kaolin-activated TEG in healthy children, to facilitate accurate interpretation of pediatric TEG results...
- The use of thromboelastography for the peripartum management of a patient with platelet storage pool disorderG Rajpal
Department of Anesthesiology, Magee Womens Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Int J Obstet Anesth 20:173-7. 2011..The use of thromboelastography in the assessment and management of bleeding risk in the setting of platelet storage pool disorder is described...
- Noncitrated whole blood is optimal for evaluation of postinjury coagulopathy with point-of-care rapid thrombelastographyJeffry L Kashuk
Department of Surgery, Denver Health Medical Center, University of Colorado at Denver, Denver, CO 80204, USA
J Surg Res 156:133-8. 2009..Point-of-care (POC) rapid thrombelastography (r-TEG) provides real time analysis of thrombostatic function, which may allow for accurate, goal directed ..
- Comparison of the effect of different platelet GPIIb/IIa antagonists on the dynamics of platelet/fibrin-mediated clot strength induced using thromboelastographyS A Mousa
Du Pont Pharmaceuticals Company, 141 and Henry Clay Road, Experimental Station, E400 3470, Wilmington, DE 19880 0400, USA
Thromb Res 104:49-56. 2001..They also suggest that inhibiting platelet aggregation may not be the sole determinant for the in vivo efficacy of various GPIIb/IIIa antagonists...
- [Possibilities and limitations of thrombelastometry/-graphy]T Lang
Abteilung für Anästhesie, Medizinische Hochschule Hannover, Germany
Hamostaseologie 26:S20-9. 2006..The introduction of rotationthrombelastometry (ROTEM) provides a stable system suitable for bedside-monitoring...
- Evaluation of post-cardiopulmonary bypass coagulation disorders by differential diagnosis with a multichannel modified thromboelastogram: a pilot investigationA Koster
Department for Anesthesia, Deutsches Herzzentrum, Berlin, Germany
J Extra Corpor Technol 33:153-8. 2001..However, elaboration is desirable, and larger clinical trials are necessary for a final evaluation of the protocol...
- Endothelial glycocalyx degradation induces endogenous heparinization in patients with severe injury and early traumatic coagulopathySisse R Ostrowski
Section for Transfusion Medicine, Copenhagen University Hospital, Copenhagen, Denmark
J Trauma Acute Care Surg 73:60-6. 2012..This study evaluated if degradation of the endothelial glycocalyx and ensuing release of its heparin-like substances induce autoheparinization and thereby contributes to TIC...
- Nanoparticle targeting of cathepsin-L inhibitor and doxorubicin in breast cancerShaker Mousa; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- FONDAPARINUM IN CHILDREN WITH THROMBOSISGuy Young; Fiscal Year: 2007..Pharmacokinetic analyses as well as safety and efficacy determinations will be made which will provide valuable information on this new anticoagulant for pediatric patients. [unreadable] [unreadable]..
- Dose-finding, pharmacokinetic, safety and efficacy of bivalirudin in childrenGuy Young; Fiscal Year: 2009..More modern therapies are available but have not been systematically tested in children. This study will determine whether one such medication, bivalirudin is a safer and more effective alterative. ..
- Regulation of Fibroblast Survival in the Collagen MatrixMark Carlson; Fiscal Year: 2005..Loss of matrix anchorage is hypothesized to reverse these effects and induce apoptosis. The involvement of each protein will be probed with mutated isoforms. ..
- Pathophysiologies Involving Hemostasis-related GenesFrancis Castellino; Fiscal Year: 2008..abstract_text> ..
- Recurrence of T1D in Pancreas TransplantationGeorge Burke; Fiscal Year: 2009..The knowledge gained should also be relevant to islet cell transplantation and spontaneous disease. ..
- Vein wall remodeling after DVT is matrix metalloproteinase dependentPeter Henke; Fiscal Year: 2009..This proposal will provide important mechanistic insight into the pathophysiology of post-phelbitic syndrome with real potential translation to decreasing the morbidity from this under-acknowledged disease. ..
- MAGNETOELASTIC SENSORS FOR BIOMEDICAL MONITORINGKEAT ONG; Fiscal Year: 2003..The wireless, remote query nature of the sensor technology would also find great utility for in-situ monitoring of biological chemical analyte concentrations such as glucose. ..
- An In-Situ Biliary Manometer for Sphincter of Oddi Dysfunction DiagnosisKEAT ONG; Fiscal Year: 2008..As an example, with proper modifications the same sensor technology can be applied for measuring the pressure within an artery stent for in-stent stenosis detection. [unreadable] [unreadable] [unreadable]..
- Symphony Multiplex Peptide Synthesizer w/ VISION WorkstnKenneth Mann; Fiscal Year: 2004..There is currently no preparative HPLC system on the campus of the University of Vermont and this system is badly needed for many investigators. ..
- PRIMARY STRUCTURE OF PROTHROMBINKenneth Mann; Fiscal Year: 2008..The major aim of this project is to elucidate the structure/function relationships of this material with respect to factor V inactivation and to access its potential significance in the pathology of human thrombosis. ..
- Thrombus resolution is CXC chemokine dependentPeter Henke; Fiscal Year: 2006..abstract_text> ..
- PE BIOSYSTEMS VOYAGER DE MALDI-TOFKenneth Mann; Fiscal Year: 2001..The fulfillment of the specific aims described in detail in the twelve research proposals would be facilitated by the addiction of a Voyager-DE MALDI-TOF ..