leukocyte count

Summary

Summary: The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells.

Top Publications

  1. ncbi Neutrophil-lymphocyte ratio as a prognostic factor in colorectal cancer
    S R Walsh
    Department of Colorectal Surgery, West Suffolk Hospital NHS Trust, UK
    J Surg Oncol 91:181-4. 2005
  2. ncbi Ratio of neutrophil to lymphocyte counts--rapid and simple parameter of systemic inflammation and stress in critically ill
    R Zahorec
    Department of Anaesthesiology and Intensive Care Medicine, St Elizabeth Cancer Institute, Bratislava
    Bratisl Lek Listy 102:5-14. 2001
  3. ncbi Neutrophil/lymphocyte ratio and its association with survival after complete resection in non-small cell lung cancer
    Khaled M Sarraf
    Academic Division of Thoracic Surgery, Royal Brompton Hospital, London, United Kingdom
    J Thorac Cardiovasc Surg 137:425-8. 2009
  4. ncbi A comparison of inflammation-based prognostic scores in patients with cancer. A Glasgow Inflammation Outcome Study
    Michael J Proctor
    University Department of Surgery, Faculty of Medicine, University of Glasgow, Royal Infirmary, Glasgow, UK
    Eur J Cancer 47:2633-41. 2011
  5. ncbi Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial
    Ruth H Green
    Institute for Lung Health, Department of Respiratory Medicine and Thoracic Surgery, Glenfield Hospital, LE3 9PQ, Leicester, UK
    Lancet 360:1715-21. 2002
  6. ncbi High white blood cell count is associated with a worsening of insulin sensitivity and predicts the development of type 2 diabetes
    Barbora Vozarova
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Diabetes 51:455-61. 2002
  7. ncbi Pretreatment neutrophil-to-lymphocyte ratio as an independent predictor of recurrence in patients with nonmetastatic renal cell carcinoma
    Yoshio Ohno
    Department of Urology, Tokyo Medical University, Tokyo, Japan
    J Urol 184:873-8. 2010
  8. ncbi The baseline ratio of neutrophils to lymphocytes is associated with patient prognosis in advanced gastric cancer
    Takeharu Yamanaka
    Institute for Clinical Research, National Kyushu Cancer Center, Fukuoka, Japan
    Oncology 73:215-20. 2007
  9. ncbi Usefulness of neutrophil to lymphocyte ratio in predicting short- and long-term mortality after non-ST-elevation myocardial infarction
    Basem Azab
    Department of Internal Medicine, Staten Island University Hospital, Staten Island, New York, NY, USA
    Am J Cardiol 106:470-6. 2010
  10. ncbi The association of total and differential white blood cell count with metabolic syndrome in type 2 diabetic patients
    Wan Sub Shim
    Department of Internal Medicine, Yonsei University College of Medicine, Seodaemoon ku, Seoul, Republic of Korea
    Diabetes Res Clin Pract 73:284-91. 2006

Research Grants

  1. TIDAL LAVAGE VS SHAM LAVAGE IN KNEE OSTEOARTHRITIS
    John Bradley; Fiscal Year: 1999
  2. Nursing Inquiry: Stress & Immune Response with Battering
    STEPHANIE WOODS; Fiscal Year: 2003
  3. Inflammation and Infection as Risk Factors in Stroke
    Mitchell Elkind; Fiscal Year: 2006
  4. Inflammatory and Infectious Burden and Risk of Stroke
    Mitchell Elkind; Fiscal Year: 2008
  5. Levels of Inflammatory Markers in Treatment of Stroke
    Mitchell Elkind; Fiscal Year: 2008
  6. Noninvasive biomarkers of proteolytic activity in CF
    Scott Sagel; Fiscal Year: 2007
  7. Hu1D10 in CLL: CLINICAL AND LABORATORY STUDIES
    John Byrd; Fiscal Year: 2006
  8. Role of Cytokines in Two Hit Organ Injury
    Jean Nemzek; Fiscal Year: 2006
  9. Interventions for Tobacco Dependent Adolescents
    Dorothy Hatsukami; Fiscal Year: 2005
  10. TREATMENT OF SMOKELESS TOBACCO USERS
    Dorothy Hatsukami; Fiscal Year: 2008

Detail Information

Publications305 found, 100 shown here

  1. ncbi Neutrophil-lymphocyte ratio as a prognostic factor in colorectal cancer
    S R Walsh
    Department of Colorectal Surgery, West Suffolk Hospital NHS Trust, UK
    J Surg Oncol 91:181-4. 2005
    ..Simple methods to identify colorectal cancer patients at risk of recurrence are needed. This study aimed to determine if neutrophil-to-lymphocyte ratio (NLR) predicts survival in colorectal cancer patients...
  2. ncbi Ratio of neutrophil to lymphocyte counts--rapid and simple parameter of systemic inflammation and stress in critically ill
    R Zahorec
    Department of Anaesthesiology and Intensive Care Medicine, St Elizabeth Cancer Institute, Bratislava
    Bratisl Lek Listy 102:5-14. 2001
    ..We investigate whether serial examination of white blood cell counts may reflect and clarify the immune response to stressful events in critically ill patients...
  3. ncbi Neutrophil/lymphocyte ratio and its association with survival after complete resection in non-small cell lung cancer
    Khaled M Sarraf
    Academic Division of Thoracic Surgery, Royal Brompton Hospital, London, United Kingdom
    J Thorac Cardiovasc Surg 137:425-8. 2009
    ..We sought to determine factors associated with increasing neutrophil/lymphocyte ratios and the stage-adjusted prognostic effect in patients undergoing resection for non-small cell lung cancer...
  4. ncbi A comparison of inflammation-based prognostic scores in patients with cancer. A Glasgow Inflammation Outcome Study
    Michael J Proctor
    University Department of Surgery, Faculty of Medicine, University of Glasgow, Royal Infirmary, Glasgow, UK
    Eur J Cancer 47:2633-41. 2011
    ..The aim of the present study was to compare the prognostic value of these scores...
  5. ncbi Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial
    Ruth H Green
    Institute for Lung Health, Department of Respiratory Medicine and Thoracic Surgery, Glenfield Hospital, LE3 9PQ, Leicester, UK
    Lancet 360:1715-21. 2002
    ..We aimed to assess whether a management strategy that minimises eosinophilic inflammation reduces asthma exacerbations compared with a standard management strategy...
  6. ncbi High white blood cell count is associated with a worsening of insulin sensitivity and predicts the development of type 2 diabetes
    Barbora Vozarova
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Diabetes 51:455-61. 2002
    ..These findings are consistent with the hypothesis that a chronic activation of the immune system may play a role in the pathogenesis of type 2 diabetes...
  7. ncbi Pretreatment neutrophil-to-lymphocyte ratio as an independent predictor of recurrence in patients with nonmetastatic renal cell carcinoma
    Yoshio Ohno
    Department of Urology, Tokyo Medical University, Tokyo, Japan
    J Urol 184:873-8. 2010
    ..We investigated the prognostic significance of the neutrophil-to-lymphocyte ratio to predict recurrence in patients with nonmetastatic renal cell carcinoma...
  8. ncbi The baseline ratio of neutrophils to lymphocytes is associated with patient prognosis in advanced gastric cancer
    Takeharu Yamanaka
    Institute for Clinical Research, National Kyushu Cancer Center, Fukuoka, Japan
    Oncology 73:215-20. 2007
    ..The objective of our study was to determine the prognostic implications of the N/L ratio in the peripheral blood of gastric cancer patients...
  9. ncbi Usefulness of neutrophil to lymphocyte ratio in predicting short- and long-term mortality after non-ST-elevation myocardial infarction
    Basem Azab
    Department of Internal Medicine, Staten Island University Hospital, Staten Island, New York, NY, USA
    Am J Cardiol 106:470-6. 2010
    ..7. We strongly suggest the use of NLR rather than other leukocyte parameters (e.g., total white blood cell count) in risk stratification of the NSTEMI population...
  10. ncbi The association of total and differential white blood cell count with metabolic syndrome in type 2 diabetic patients
    Wan Sub Shim
    Department of Internal Medicine, Yonsei University College of Medicine, Seodaemoon ku, Seoul, Republic of Korea
    Diabetes Res Clin Pract 73:284-91. 2006
    ..We investigated the relation between total and differential white blood cell (WBC) count and metabolic syndrome (MS) in type 2 diabetic patients...
  11. pmc White blood cell counts and malaria
    F Ellis McKenzie
    Fogarty International Center, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Infect Dis 192:323-30. 2005
    ..For instance, in the present study, use of this conventional approach would have overestimated average asexual parasite densities in the P. falciparum-infected patients in Thailand by nearly one-third...
  12. ncbi Negative impact of neutrophil-lymphocyte ratio on outcome after liver transplantation for hepatocellular carcinoma
    Karim J Halazun
    Department of Organ Transplantation, New York Presbyterian Hospital, Columbia University, MHB 7GS 313, 177 Ft Washington Avenue, New York, NY 10032, USA
    Ann Surg 250:141-51. 2009
    ..We aimed to determine whether NLR predicts outcome in patients undergoing OLT for HCC...
  13. ncbi Longitudinal study on white blood cell count and the incidence of metabolic syndrome
    Keiichi Odagiri
    YAMAHA Health Care Center, Japan
    Intern Med 50:2491-8. 2011
    ..However, few cohort studies have examined the role of WBC in the development of MetS. We hypothesized that WBC is associated with the future development of MetS, and investigated the longitudinal incidence of MetS in healthy workers...
  14. pmc The relationships between body composition and the systemic inflammatory response in patients with primary operable colorectal cancer
    Colin H Richards
    University Department of Surgery, Glasgow Royal Infirmary, Glasgow, United Kingdom
    PLoS ONE 7:e41883. 2012
    ..The aim of the present study was to examine the relationships between CT measured parameters of body composition and the systemic inflammatory response in patients with primary operable colorectal cancer...
  15. ncbi High blood neutrophil-to-lymphocyte ratio is an indicator of poor prognosis in malignant mesothelioma patients undergoing systemic therapy
    Steven C H Kao
    Department of Medical Oncology, Sydney Cancer Centre, Australia
    Clin Cancer Res 16:5805-13. 2010
    ..We have investigated blood neutrophil-to-lymphocyte ratio (NLR), an index of systemic inflammation, as a prognostic factor in MM patients...
  16. ncbi Leukocyte count as an independent predictor of recurrent ischemic events
    Armin J Grau
    Neurologische Klinik, Klinikum der Stadt Ludwigshafen a Rh, Bremserstr 70, D 67063 Ludwigshafen, Germany
    Stroke 35:1147-52. 2004
    ..We investigated whether leukocyte and differential counts predict recurrent events and ischemic events in high-risk populations, and whether such events are preceded by acutely exacerbated inflammation...
  17. ncbi Utility of the neutrophil to lymphocyte ratio in predicting long-term outcomes in acute decompensated heart failure
    Shanmugam Uthamalingam
    Massachusetts General Hospital, Boston, USA
    Am J Cardiol 107:433-8. 2011
    ..NLR is a readily available inexpensive marker to aid in the risk stratification of patients with ADHF...
  18. pmc A derived neutrophil to lymphocyte ratio predicts survival in patients with cancer
    M J Proctor
    University Department of Surgery, Faculty of Medicine, Royal Infirmary, University of Glasgow, Glasgow G31 2 ER, UK
    Br J Cancer 107:695-9. 2012
    ..The aim of the present study was to compare the prognostic value of the NLR with a derived score (dNLR), composed of white cell and neutrophil counts...
  19. ncbi The nature of small-airway obstruction in chronic obstructive pulmonary disease
    James C Hogg
    University of British Columbia, the Centre for Cardiovascular and Pulmonary Research, and St Paul s Hospital, Vancouver, Canada
    N Engl J Med 350:2645-53. 2004
    ..We examined the evolution of the pathological effects of airway obstruction in patients with COPD...
  20. ncbi Impact of immune parameters on long-term survival in metastatic renal cell carcinoma
    Frede Donskov
    Department of Oncology, Aarhus University Hospital, Aarhus C, Denmark
    J Clin Oncol 24:1997-2005. 2006
    ..The purpose of this study was to evaluate the impact of immunologic prognostic factors in combination with established clinical prognostic factors in patients with metastatic renal cell carcinoma (mRCC)...
  21. ncbi Association of peripheral total and differential leukocyte counts with metabolic syndrome and risk of ischemic cardiovascular diseases in patients with type 2 diabetes mellitus
    Jack C R Tsai
    Department of Clinical Research, Pingtung Christian Hospital, Pingtung, 90000, Taiwan
    Diabetes Metab Res Rev 23:111-8. 2007
    ....
  22. pmc Comparison of the prognostic value of selected markers of the systemic inflammatory response in patients with colorectal cancer
    E F Leitch
    1University Department of Surgery, Royal Infirmary, Glasgow G31 2ER, UK
    Br J Cancer 97:1266-70. 2007
    ..An acute-phase protein-based prognostic score, the mGPS, appears to be a superior predictor of survival compared with the cellular components of the systemic inflammatory response...
  23. ncbi Changes in white blood cells and platelets in children with falciparum malaria: relationship to disease outcome
    Shamez Ladhani
    Centre for Geographical Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
    Br J Haematol 119:839-47. 2002
    ..Thus, leucocytosis was associated with both severity and mortality in children with falciparum malaria, irrespective of bacteraemia, whereas thrombocytopenia, although very common, was not associated with adverse outcome...
  24. ncbi Prognostic value of pre-treatment circulating monocyte count in patients with cervical cancer: comparison with SCC-Ag level
    Yoo Young Lee
    Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    Gynecol Oncol 124:92-7. 2012
    ..We investigated the role of pre-treatment circulating monocyte count for cancer specific survival in cervical squamous cell carcinoma patients comparing with pre-treatment squamous cell carcinoma-related antigen (SCC-Ag) level...
  25. pmc Differential white blood cell count and type 2 diabetes: systematic review and meta-analysis of cross-sectional and prospective studies
    Effrossyni Gkrania-Klotsas
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, United Kingdom
    PLoS ONE 5:e13405. 2010
    ..However, the association has not been systematically investigated...
  26. pmc Black-white divergence in the relation of white blood cell count to metabolic syndrome in preadolescents, adolescents, and young adults: the Bogalusa Heart Study
    Wei Chen
    Department of Epidemiology, Tulane Center for Cardiovascular Health, Tulane University, New Orleans, Louisiana, USA
    Diabetes Care 33:2474-6. 2010
    ..To examine the association between white blood cell (WBC) count and metabolic syndrome (MetS) by growth periods in black versus white individuals in the general population...
  27. pmc Lymphocytopenia and neutrophil-lymphocyte count ratio predict bacteremia better than conventional infection markers in an emergency care unit
    Cornelis P C de Jager
    Department of Emergency Medicine and Intensive Care, Jeroen Bosch Ziekenhuis, Tolbrugstraat 11, 5200 ME s Hertogenbosch, The Netherlands
    Crit Care 14:R192. 2010
    ..Likewise, the neutrophil-lymphocyte count ratio (NLCR) has been shown a simple promising method to evaluate systemic inflammation in critically ill patients...
  28. ncbi The absolute monocyte count is associated with overall survival in patients newly diagnosed with follicular lymphoma
    Ryan A Wilcox
    Department of Internal Medicine, Division of Hematology Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI 48109 5948, USA
    Leuk Lymphoma 53:575-80. 2012
    ..These results further support the central role of non-neoplastic myeloid-lineage cells in follicular lymphoma biology...
  29. ncbi Pretreatment neutrophil count as an independent prognostic factor in advanced non-small-cell lung cancer: an analysis of Japan Multinational Trial Organisation LC00-03
    Satoshi Teramukai
    Department of Clinical Trial Design and Management, Translational Research Center, Kyoto University Hospital, Kyoto 606 8507, Japan
    Eur J Cancer 45:1950-8. 2009
    ..Neutrophil count is easily measured at low cost, and it may be a useful indicator of patient prognosis...
  30. pmc Clinical risk factors for severe Clostridium difficile-associated disease
    Timothy J Henrich
    Division of Infectious Diseases, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Emerg Infect Dis 15:415-22. 2009
    ..05): age >70 years (odds ratio [OR] 3.35), maximum leukocyte count >20,000 cells/mL (OR 2.77), minimum albumin level <2.5 g/dL (OR 3...
  31. ncbi Comparison of the prognostic values of various inflammation based factors in patients with pancreatic cancer
    De Shen Wang
    State Key Laboratory of Oncology in South China, Sun Yat sen University Cancer Center, 651 Dong Feng Road East, Guangzhou, 510060, China
    Med Oncol 29:3092-100. 2012
    ..200 months (p < 0.001). Our study demonstrates that elevated NLR is superior to the mGPS, PI, PLR and PNI for prognostication in patients with pancreatic cancer...
  32. ncbi Followup of neutrophil-to-lymphocyte ratio and recurrence of clear cell renal cell carcinoma
    Yoshio Ohno
    Department of Urology, Tokyo Medical University, Tokyo, Japan
    J Urol 187:411-7. 2012
    ..However, the clinical implication of a posttreatment change in the neutrophil-to-lymphocyte ratio in patients with cancer remains unclear...
  33. ncbi Can neutrophil-to-lymphocyte ratio predict the survival of colorectal cancer patients who have received curative surgery electively?
    Sum Fu Chiang
    Division of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital, 5 Fu Hsing St, Kuei Shan Hsiang, Taoyuan, Linkou, Taiwan
    Int J Colorectal Dis 27:1347-57. 2012
    ..We evaluated the effect of neutrophil-to-lymphocyte ratio (NLR) on disease-free survival in patients with stages I to III colorectal cancer (CRC)...
  34. pmc Population-based hematologic and immunologic reference values for a healthy Ugandan population
    Eric S Lugada
    Center for International Health, University of Bergen, Bergen, Norway
    Clin Diagn Lab Immunol 11:29-34. 2004
    ..These differences could influence the decision to initiate antiretroviral therapy among children infected with HIV...
  35. ncbi High preoperative neutrophil-lymphocyte ratio predicts poor survival in patients with gastric cancer
    Hideaki Shimada
    Department of Gastroenterological Surgery, Chiba Cancer Center, Chiba, Japan
    Gastric Cancer 13:170-6. 2010
    ..An elevated NLR has been reported to be a prognostic indicator in some malignant tumors. The aim of this study was to evaluate the clinical significance of the preoperative NLR in patients with primary gastric cancer...
  36. pmc Relation between lymphopenia and bacteraemia in UK adults with medical emergencies
    D H Wyllie
    Nuffield Departments of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    J Clin Pathol 57:950-5. 2004
    ..To determine the relevance of lymphopenia to the diagnosis of bacteraemia in patients admitted with medical emergencies, relative to peripheral blood white cell count and neutrophilia...
  37. ncbi The effect of abrupt weaning of suckler calves on the plasma concentrations of cortisol, catecholamines, leukocytes, acute-phase proteins and in vitro interferon-gamma production
    M C Hickey
    Teagasc, Grange Research Centre, Dunsany, Co Meath, Ireland
    J Anim Sci 81:2847-55. 2003
    ..Abrupt weaning increased plasma cortisol and noradrenaline concentrations that were accompanied by attenuation of in vitro interferon-gamma production to novel mitogen and antigen complexes up to 7 d after weaning...
  38. ncbi Which white blood cell subtypes predict increased cardiovascular risk?
    Benjamin D Horne
    Cardiovascular Department, LDS Hospital, Salt Lake City, Utah 84143, USA
    J Am Coll Cardiol 45:1638-43. 2005
    ..We sought to determine the predictive ability of total white blood cell (WBC) count and its subtypes for risk of death or myocardial infarction (MI)...
  39. ncbi Leukocyte count as a predictor of cardiovascular events and mortality in postmenopausal women: the Women's Health Initiative Observational Study
    Karen L Margolis
    Hennepin County Medical Center, and Berman Center for Outcomes and Clinical Research, 825 S Eighth Street, Minneapolis, MN 55404, USA
    Arch Intern Med 165:500-8. 2005
    Increasing evidence supports a role for inflammation in the atherosclerotic process. The role of the leukocyte count as an independent predictor of risk of a first cardiovascular disease (CVD) event remains uncertain...
  40. ncbi Polymorphonuclear neutrophils and cancer: intense and sustained neutrophilia as a treatment against solid tumors
    Juan Carlos Souto
    Department of Hematology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Med Res Rev 31:311-63. 2011
    ..This antitumoral role of neutrophils may provide new avenues for the clinical treatment of cancer...
  41. ncbi Relative elevation in baseline leukocyte count predicts first cerebral infarction
    M S V Elkind
    Department of Neurology, Columbia University College of Physicians and Surgeons, Joseph Mailman School of Public Health, New York, NY, USA
    Neurology 64:2121-5. 2005
    ..Atherosclerosis is an inflammatory disease, and leukocyte levels are associated with future risk of ischemic cardiac disease...
  42. ncbi Synovial fluid leukocyte count and differential for the diagnosis of prosthetic knee infection
    Andrej Trampuz
    Division of Infectious Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Am J Med 117:556-62. 2004
    ..Our aim was to define cutoff values for synovial fluid leukocyte count and neutrophil percentage for differentiating aseptic failure and prosthetic joint infection.
  43. ncbi An early and sustained peripheral inflammatory response in acute ischaemic stroke: relationships with infection and atherosclerosis
    Hedley C A Emsley
    University of Manchester, Manchester, UK
    J Neuroimmunol 139:93-101. 2003
    ....
  44. ncbi Leukocyte count is associated with aortic arch plaque thickness
    Mitchell S V Elkind
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, USA
    Stroke 33:2587-92. 2002
    b>Leukocyte count has been associated with cardiovascular and cerebrovascular disease, including carotid plaque thickness, in several studies...
  45. pmc The neutrophil-lymphocyte count ratio in patients with community-acquired pneumonia
    Cornelis P C de Jager
    Department of Emergency Medicine and Intensive Care, Jeroen Bosch Ziekenhuis, s Hertogenbosch, The Netherlands
    PLoS ONE 7:e46561. 2012
    ..The neutrophil-lymphocyte count ratio (NLCR) has been identified as a predictor of bacteremia in medical emergencies. The aim of this study was to investigate the value of the NLCR in patients with community-acquired pneumonia (CAP)...
  46. ncbi Automated blood cell counts: state of the art
    Mauro Buttarello
    Department of Laboratory Medicine, University Hospital of Padova, Padova, Italy
    Am J Clin Pathol 130:104-16. 2008
    ....
  47. ncbi Cytokine response to diabetic ketoacidosis (DKA) in children with type 1 diabetes (T1DM)
    Kyriaki Karavanaki
    Diabetic Clinic, B Paediatric Department, University of Athens Medical School, P and A Kyriakou Children s Hospital, Athens, Greece
    Endocr J 58:1045-53. 2011
    ..These changes may be responsible for increased capillary perturbation, which could lead to the subsequent development of acute DKA complications...
  48. ncbi Elevated systemic neutrophil count in diabetic retinopathy and diabetes: a hospital-based cross-sectional study of 30,793 Korean subjects
    Se Joon Woo
    Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital SNUBH, Seongnam, Korea
    Invest Ophthalmol Vis Sci 52:7697-703. 2011
    ..To evaluate the association between systemic parameters including inflammatory markers and diabetic retinopathy (DR)...
  49. ncbi Elevated white blood cell count and carotid plaque thickness : the northern manhattan stroke study
    M S Elkind
    Department of Neurology, Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Stroke 32:842-9. 2001
    Elevated leukocyte count has been associated with cardiovascular and cerebrovascular disease in several epidemiological studies...
  50. ncbi Prospective study of hemostatic factors and incidence of coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) Study
    A R Folsom
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55454 1015, USA
    Circulation 96:1102-8. 1997
    ..Although hemostatic factors contribute to acute coronary syndromes and atherogenesis, few studies have prospectively evaluated the association between multiple hemostatic factors and coronary heart disease incidence...
  51. ncbi White blood cell count is associated with carotid and femoral atherosclerosis
    Emilio Ortega
    Endocrinology and Nutrition Service, Institut d Investigacions Biomèdiques August Pi Sunyer, Hospital Clinic, Barcelona, Spain
    Atherosclerosis 221:275-81. 2012
    ..Ultrasound imaging allows measurement of intima-media thickness (IMT) and plaque. We investigated the association between inflammatory markers and carotid and femoral atherosclerosis...
  52. ncbi The prevalence of metabolic syndrome and diabetes increases through the quartiles of white blood cell count in Japanese men and women
    Eiji Oda
    Medical Check up Center, Tachikawa Medical Center, Nagaoka
    Intern Med 48:1127-34. 2009
    ..Low-grade systemic inflammation is proposed as a component of metabolic syndrome (MS) and is reported as a predictor of diabetes. We studied the association between white blood cell count (WBC) and MS and diabetes in Japanese men and women...
  53. ncbi Cytokines in rats experimentally infected with Trypanosoma evansi
    Francine C Paim
    Laboratory of Veterinary Clinical Analysis LACVet, Federal University of Santa Maria, 97105 900 Santa Maria, RS, Brazil
    Exp Parasitol 128:365-70. 2011
    ..These results suggest a synergism among IL-1, TNF-α and IFN-γ contributing to the development of anemia. This increase is associated with the regulation of immune responses against the parasite...
  54. ncbi Association of fibrinogen, C-reactive protein, albumin, or leukocyte count with coronary heart disease: meta-analyses of prospective studies
    J Danesh
    Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Clinical Medicine, University of Oxford, England
    JAMA 279:1477-82. 1998
    ..A large number of epidemiologic studies have reported on associations between various "inflammatory" factors and coronary heart disease (CHD)...
  55. ncbi Comparison of alanine aminotransferase, white blood cell count, and uric acid in their association with metabolic syndrome: a study of Korean adults
    Yang Ho Kang
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea
    Endocr J 55:1093-102. 2008
    ..Among three markers, in overlap the multiple risk factors, ALT might have a strong association with metabolic syndrome in Korean adults...
  56. pmc Outcome predictability of biomarkers of protein-energy wasting and inflammation in moderate and advanced chronic kidney disease
    Csaba P Kovesdy
    Salem VA Medical Center, Salem, VA 24153, USA
    Am J Clin Nutr 90:407-14. 2009
    ..Markers of protein-energy wasting (PEW) and inflammation are common in chronic kidney disease (CKD) and are among the strongest predictors of mortality in dialysis patients...
  57. ncbi Comparison of four hematology analyzers, CELL-DYN Sapphire, ADVIA 120, Coulter LH 750, and Sysmex XE-2100, in terms of clinical usefulness
    S H Kang
    Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    Int J Lab Hematol 30:480-6. 2008
    ..0%); and LH 750 showed the highest sensitivity for Nucleated RBC flag (75.0%). Our results demonstrate that the four analyzers are comparable in overall performance...
  58. pmc Depression and inflammation in patients with coronary heart disease: findings from the Heart and Soul Study
    Mary A Whooley
    Department of Veterans Affairs Medical Center, San Francisco, California University of California, San Francisco, CA 94121, USA
    Biol Psychiatry 62:314-20. 2007
    ..However, studies investigating the link between depression and inflammation in patients with established CHD have produced inconclusive results...
  59. ncbi Musculoskeletal manifestations in pediatric acute leukemia
    Riccardo Sinigaglia
    Sandro Agostini Spine Surgery Unit, Padua University Hospital, Padua, Italy
    J Pediatr Orthop 28:20-8. 2008
    ..In children, acute leukemia (AL) at presentation can mimic several orthopaedic pathologies, so that a variable delay of the correct diagnosis is often reported...
  60. ncbi Differential leucocyte count and the risk of future coronary artery disease in healthy men and women: the EPIC-Norfolk Prospective Population Study
    J S Rana
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    J Intern Med 262:678-89. 2007
    ..There is paucity of data on the differential leucocyte count and its relationship with the risk of CHD and CVD...
  61. ncbi Effect of serotypes on clinical manifestations of dengue fever in adults
    Jih Jin Tsai
    Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
    J Microbiol Immunol Infect 42:471-8. 2009
    ..However, it is unclear whether different dengue virus serotypes (DENV) are associated with different clinical manifestations and outcomes. This study investigated the association between viral serotype and clinical manifestations of DF...
  62. ncbi Antiinflammatory effects of salmeterol/fluticasone propionate in chronic obstructive lung disease
    Neil C Barnes
    Department of Respiratory Medicine, London Chest Hospital, London, UK
    Am J Respir Crit Care Med 173:736-43. 2006
    ..No currently available treatment is reported to reduce the exaggerated airway wall inflammation of chronic obstructive pulmonary disease...
  63. ncbi Serum and ascitic procalcitonin levels in cirrhotic patients with spontaneous bacterial peritonitis: diagnostic value and relationship to pro-inflammatory cytokines
    A Viallon
    Emergency and Intensive Care Units, Bellevue Hospital, Saint Etienne, France
    Intensive Care Med 26:1082-8. 2000
    ..To assess the potential role of procalcitonin and pro-inflammatory cytokines, TNF-alpha, and IL-6, in the diagnosis of spontaneous bacterial peritonitis (SBP)...
  64. ncbi Relationship of monocyte count and peripheral arterial disease: results from the National Health and Nutrition Examination Survey 1999-2002
    Khurram Nasir
    Cardiology Division, Department of Medicine, Johns Hopkins University, Baltimore, MD 21287 0409, USA
    Arterioscler Thromb Vasc Biol 25:1966-71. 2005
    ....
  65. ncbi Monocyte subtypes predict clinical course and prognosis in human stroke
    Xabier Urra
    Functional Unit of Cerebrovascular Diseases, Hospital Clinic, Barcelona, Spain
    J Cereb Blood Flow Metab 29:994-1002. 2009
    ..Therefore, monitoring of monocyte subtypes may emerge as a useful tool at the bedside for stroke patients...
  66. ncbi Clinical, radiologic, and induced sputum features of chronic obstructive pulmonary disease in nonsmokers: a descriptive study
    Surinder S Birring
    Department of Respiratory Medicine, Radiology, and Respiratory Physiology, and Leicester Children s Asthma Centre, Institute for Lung Health, Glenfield Hospital, Leicester, United Kingdom
    Am J Respir Crit Care Med 166:1078-83. 2002
    ..Further investigation of this group may disclose novel mechanisms of fixed airflow obstruction...
  67. ncbi Periprosthetic infection: what are the diagnostic challenges?
    Javad Parvizi
    J Bone Joint Surg Am 88:138-47. 2006
  68. ncbi Leukocyte count and coronary heart disease: implications for risk assessment
    Mohammad Madjid
    University of Texas Houston Health Science Center, USA
    J Am Coll Cardiol 44:1945-56. 2004
    Inflammation is a key feature of atherosclerosis and its clinical manifestations. The leukocyte count is a marker of inflammation that is widely available in clinical practice...
  69. ncbi White blood cell count and incidence of coronary heart disease and ischemic stroke and mortality from cardiovascular disease in African-American and White men and women: atherosclerosis risk in communities study
    C D Lee
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, 55454-1015, USA
    Am J Epidemiol 154:758-64. 2001
    ..An elevated WBC count is directly associated with increased incidence of coronary heart disease and ischemic stroke and mortality from cardiovascular disease in African-American and White men and women...
  70. ncbi Obesity and the white blood cell count: changes with sustained weight loss
    John B Dixon
    Australian Centre for Obesity Research and Education, Monash Medical School, The Alfred Hospital, Melbourne, Victoria, Australia
    Obes Surg 16:251-7. 2006
    ..The authors explored the relationship between the WBC and degree of obesity, basic anthropometry, and clinical and biochemical markers of the metabolic syndrome at baseline, and with weight loss following Lap-Band surgery...
  71. pmc The associations of total and differential white blood cell counts with obesity, hypertension, dyslipidemia and glucose intolerance in a Korean population
    Dong Jun Kim
    Department of Internal Medicine, Ilsanpaik Hostipal, Inje University College of Medicine, Goyang, Korea
    J Korean Med Sci 23:193-8. 2008
    ..Our data suggest that even within normal ranges, total WBC count and the differential WBC counts are associated with the presence of metabolic syndrome...
  72. ncbi White blood-cell count and the risk of impaired fasting glucose or Type II diabetes in middle-aged Japanese men
    N Nakanishi
    Department of Social and Environmental Medicine, Course of Social Medicine, Osaka University Graduate School of Medicine F2, 2 2 Yamada oka, Suita Shi, Osaka 565 0871, Japan
    Diabetologia 45:42-8. 2002
    ..To investigate the association between white blood-cell (WBC) count and the development of diabetes, independent of cigarette smoking...
  73. ncbi Relationship between systemic markers of inflammation and serum beta-carotene levels
    T P Erlinger
    Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, 2024 E Monument St, Suite 2 600, Baltimore, MD 21205, USA
    Arch Intern Med 161:1903-8. 2001
    ..This pattern of findings raises the possibility that confounding by other factors might explain the association between serum beta-carotene level and disease risk...
  74. ncbi Sepsis severity predicts outcome in community-acquired pneumococcal pneumonia
    B Schaaf
    Medical Clinic III, University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Eur Respir J 30:517-24. 2007
    ..The prediction of survival in the intermediate-risk group might be more accurate with the sepsis score. Pre-hospital antibiotic treatment was associated with less severe disease...
  75. ncbi Clinical profile of homozygous JAK2 617V>F mutation in patients with polycythemia vera or essential thrombocythemia
    Alessandro M Vannucchi
    Department of Hematology, University of Florence, 50134 Florence, Italy
    Blood 110:840-6. 2007
    ..Irrespective of their clinical diagnosis, homozygous patients were older, displayed a higher leukocyte count and hematocrit value at diagnosis, and presented larger spleen volume...
  76. ncbi Early and late markers for the detection of early-onset neonatal sepsis
    L Bender
    Department of Paediatrics, Aalborg Hospital, University of Aarhus, Aalborg, Denmark
    Dan Med Bull 55:219-23. 2008
    ..In this study we tested how a combination of early and late paraclinic markers could predict early onset neonatal sepsis (EONS)...
  77. ncbi Do peripheral blood counts have any prognostic value following trauma?
    T H Rainer
    Accident and Emergency Medicine Academic Unit, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, People s Republic of China
    Injury 30:179-85. 1999
    ..The purpose of this study was to determine the early serial changes in peripheral leucocyte counts following injury...
  78. pmc Use of plasma C-reactive protein, procalcitonin, neutrophils, macrophage migration inhibitory factor, soluble urokinase-type plasminogen activator receptor, and soluble triggering receptor expressed on myeloid cells-1 in combination to diagnose infections
    Kristian Kofoed
    Clinical Research Unit, Copenhagen University Hospital, Hvidovre, Kettegaard Alle 30, DK 2650 Hvidovre, Denmark
    Crit Care 11:R38. 2007
    ..Combinations of markers, as opposed to single ones, may improve diagnosis and thereby survival. We therefore compared the diagnostic characteristics of novel and routinely used biomarkers of sepsis alone and in combination...
  79. ncbi Preoperative C-reactive protein level and outcome following coronary surgery
    Mario Gaudino
    Department of Cardiac Surgery, Catholic University, Rome, Italy
    Eur J Cardiothorac Surg 22:521-6. 2002
    ..It has been suggested that a preoperative level of C-reactive protein (CRP)>5mg/l is predictive of postoperative complications in cardiac surgery patients...
  80. ncbi Serum C3 is a stronger inflammatory marker of insulin resistance than C-reactive protein, leukocyte count, and erythrocyte sedimentation rate: comparison study in an elderly population
    Antonio Muscari
    Department of Internal Medicine, Cardioangiology, and Hepatology, University of Bologna, Bologna, Italy
    Diabetes Care 30:2362-8. 2007
    ..This study was performed to ascertain the relative relevance of some inflammatory markers in insulin resistance...
  81. ncbi Early markers of late-onset sepsis in premature neonates: clinical, hematological and cytokine profile
    Blanca E Gonzalez
    Department of Medicine, Division of Neonatology, Department of Pediatrics, Albert Einstein Medical Center, Philadelphia, USA
    J Perinat Med 31:60-8. 2003
    ..Late-onset sepsis in the NICU is a major problem associated with high morbidity and mortality...
  82. ncbi Clinical utility of the band count
    P Joanne Cornbleet
    Department of Pathology, Stanford University Medical Center, Stanford, California, USA
    Clin Lab Med 22:101-36. 2002
    ..In the near future, rapid analysis of inflammatory factors, adhesion molecules, cytokines, neutrophil surface antigens, or even bacterial DNA may be superior alternative tests for the early diagnosis of sepsis...
  83. ncbi The immunomodulatory actions of prostaglandin E2 on allergic airway responses in the rat
    James G Martin
    Meakins Christie Laboratories, Department of Medicine, McGill University, Montreal, Quebec, Canada
    J Immunol 169:3963-9. 2002
    ..We conclude that PGE(2) is a potent anti-inflammatory agent that may act by reducing allergen-induced Th2 cell activation and cysteinyl-leukotriene synthesis in the rat...
  84. pmc Diagnostic and prognostic accuracy of clinical and laboratory parameters in community-acquired pneumonia
    Beat Muller
    Departments of Internal Medicine, University Hospital, Petersgraben 4, CH 4031, Basel, Switzerland
    BMC Infect Dis 7:10. 2007
    ..This study aims to evaluate the diagnostic and prognostic accuracy of clinical signs and symptoms and laboratory biomarkers for CAP...
  85. ncbi White blood cell count and the metabolic syndrome in older Chinese: the Guangzhou Biobank Cohort Study
    Xiang Qian Lao
    Department of Community Medicine and School of Public Health, The University of Hong Kong, Pokfulam, Hong Kong
    Atherosclerosis 201:418-24. 2008
    ..To examine the association between white blood cell count (WBC) and metabolic syndrome (MS) in an older Chinese population...
  86. ncbi White blood cell count and risk for all-cause, cardiovascular, and cancer mortality in a cohort of Koreans
    Sun Ha Jee
    Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea
    Am J Epidemiol 162:1062-9. 2005
    ..lowest quintile: hazard ratio = 1.46, 95% confidence interval: 1.25, 1.72). These findings indicate that the white blood cell count is an independent risk factor for all-cause mortality and for ASCVD mortality...
  87. ncbi Preoperative neutrophil-lymphocyte ratio and outcome from coronary artery bypass grafting
    Patrick H Gibson
    Department of Cardiology, University of Aberdeen and Aberdeen Royal Infirmary, Aberdeen, United Kingdom
    Am Heart J 154:995-1002. 2007
    ..We hypothesized that the N/L ratio would predict the outcome of patients undergoing surgical revascularization...
  88. ncbi Relationship between white blood cell count and incident hypertension
    Anoop Shankar
    Department of Ophthalmology, University of Wisconsin Medical School, 610 N Walnut Street, 405 WARF, Madison, WI 53726 2336, USA
    Am J Hypertens 17:233-9. 2004
    ..However, its relationship to hypertension, independent of smoking and other established cardiovascular risk factors, is not clear, especially among women...
  89. ncbi Acute stress enhances while chronic stress suppresses cell-mediated immunity in vivo: a potential role for leukocyte trafficking
    F S Dhabhar
    Rockefeller University, New York, NY 10021, USA
    Brain Behav Immun 11:286-306. 1997
    ..These results suggest that stress-induced alterations in lymphocyte redeployment may play an important role in mediating the bi-directional effects of acute versus chronic stress on cell-mediated immunity in vivo...
  90. pmc Smoking cessation and cardiovascular disease risk factors: results from the Third National Health and Nutrition Examination Survey
    Arvind Bakhru
    University of Rochester Medical Center, School of Medicine, Rochester, New York, USA
    PLoS Med 2:e160. 2005
    ..It also remains unclear as to whether traditional risk factors can adequately explain the observed decline in cardiovascular risk following smoking cessation...
  91. ncbi Automated enumeration of immature granulocytes
    Bernard Fernandes
    Department of Laboratory Medicine, Mount Sinai Hospital and University of Toronto, Toronto, Canada
    Am J Clin Pathol 128:454-63. 2007
    ..The results also confirm that the flow cytometric IG count is superior to and can replace the manual morphology count as a reference method for IG counting...
  92. ncbi Relation of markers of inflammation (C-reactive protein, fibrinogen, von Willebrand factor, and leukocyte count) and statin therapy to long-term mortality in patients with angiographically proven coronary artery disease
    Christoph Bickel
    Department of Medicine II, Johannes Gutenberg University Mainz, Germany
    Am J Cardiol 89:901-8. 2002
    ..001), fibrinogen (p = 0.006), von Willebrand factor (p = 0.006), and leukocyte count (p = 0...
  93. ncbi Inducible cardiac ischaemia is related to a decrease in the whole-blood Toll-like receptor 2 and 4 response
    Ellen H A M Elsenberg
    Laboratory of Experimental Cardiology, University Medical Centre Utrecht, Utrecht, The Netherlands
    Clin Sci (Lond) 122:527-33. 2012
    ..These results point to a regulating role of TLRs in order to prevent excessive inflammatory events known to occur during acute ischaemia...
  94. ncbi Role of neutrophil to lymphocyte ratio as a prognostic indicator for epithelial ovarian cancer
    Thaovalai Thavaramara
    Department of Obstetrics and Gynecology, Bangkok Metropolitan Administration Medical College and Vajira Hospital, Bangkok, Thailand
    J Med Assoc Thai 94:871-7. 2011
    ..The present study further aimed to evaluate the impact of the change of preoperative/postoperative NLR on the survival...
  95. ncbi The open window of susceptibility to infection after acute exercise in healthy young male elite athletes
    M W Kakanis
    Faculty of Health Sciences and Medicine, Bond University, Robina, Queensland, Australia
    Exerc Immunol Rev 16:119-37. 2010
    ..Suppression of total lymphocyte counts, NK cell counts and neutrophil phagocytic function following exercise may be important in the increased rate of URI in response to regular intense endurance training...
  96. ncbi Leukocyte count is an independent predictor for risk of acute myocardial infarction in middle-aged Japanese men
    Hironori Imano
    Osaka Medical Center for Health Science and Promotion, 1 3 2 Nakamichi, Higashinari ku, Osaka Shi, Osaka 537 0025, Japan
    Atherosclerosis 195:147-52. 2007
    b>Leukocyte count is recognized as an inflammatory marker and a predictor of cardiovascular events. However, it is uncertain whether the contribution of leukocyte count to the risk of cardiovascular disease is independent of smoking.
  97. ncbi Procalcitonin predicts patients at low risk of death from community-acquired pneumonia across all CRB-65 classes
    S Kruger
    Dept of Internal Medicine II, Ulm University Hospital, Ulm, Germany
    Eur Respir J 31:349-55. 2008
    ..prognostic accuracy as the CRB-65 score and a higher prognostic accuracy compared with C-reactive protein and leukocyte count. Procalcitonin levels can provide independent identification of patients at low risk of death within CRB-65 (..
  98. ncbi Eosinopenia: Is it a good marker of sepsis in comparison to procalcitonin and C-reactive protein levels for patients admitted to a critical care unit in an urban hospital?
    Hamid Shaaban
    Infectious Diseases Division, St Michael s Medical Center, Newark, NJ 07102, USA
    J Crit Care 25:570-5. 2010
    ..The role of eosinopenia as a marker of sepsis has recently been evaluated. The aim of our study was to test the value of eosinopenia as a diagnostic marker of sepsis in comparison to procalcitonin and C-reactive protein levels...
  99. pmc Bacteraemia prediction in emergency medical admissions: role of C reactive protein
    D H Wyllie
    Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    J Clin Pathol 58:352-6. 2005
    ..To define the contribution made by C reactive protein (CRP) measurement to bacteraemia prediction in adults with medical emergencies in the UK...
  100. ncbi Plasma glucose levels and white blood cell count are related with ankle brachial index in type 2 diabetic subjects
    Athanasia Papazafiropoulou
    3rd Department of Internal Medicine and Center of Diabetes, General Hospital of Nikaia Ag Panteleimon, Piraeus, Greece
    Hellenic J Cardiol 51:402-6. 2010
    ..The aim of the present study was to determine whether there is an association between ABI and cardiovascular risk factors in T2DM subjects without apparent macrovascular disease...
  101. ncbi Eosinopenia as a diagnostic marker of bloodstream infection in hospitalised paediatric and adult patients: a case-control study
    B A Wibrow
    Royal Perth Hospital and Princess Margaret Hospital for Children, Perth, Western Australia, Australia
    Anaesth Intensive Care 39:224-30. 2011
    ..C-reactive protein concentrations and neutrophil counts were both better markers of bloodstream infection than eosinopenia in hospitalised paediatric and adult patients...

Research Grants76

  1. TIDAL LAVAGE VS SHAM LAVAGE IN KNEE OSTEOARTHRITIS
    John Bradley; Fiscal Year: 1999
    ..specific characteristics, including baseline WOMAC score; radiographic severity of OA, synovial fluid leukocyte count and crystal content; and general health status, as measured by the Quality of Well Being (QWB) scale...
  2. Nursing Inquiry: Stress & Immune Response with Battering
    STEPHANIE WOODS; Fiscal Year: 2003
    ..childhood maltreatment as a moderator of PTSD symptoms in battered women; 4) describe immune status via leukocyte count, lymphocyte subset counts (CD4 cell, CD8 cell, B-cell, and natural killer cell), CD4:CD8 ratio, number of ..
  3. Inflammation and Infection as Risk Factors in Stroke
    Mitchell Elkind; Fiscal Year: 2006
    ..Nationally recognized experts in stroke epidemiology and basic vascular biology will serve as mentors for these studies. ..
  4. Inflammatory and Infectious Burden and Risk of Stroke
    Mitchell Elkind; Fiscal Year: 2008
    ..The cross-sectional associations between inflammatory and infectious markers and quantitative MRI abnormalities will also be assessed. ..
  5. Levels of Inflammatory Markers in Treatment of Stroke
    Mitchell Elkind; Fiscal Year: 2008
    ..abstract_text> ..
  6. Noninvasive biomarkers of proteolytic activity in CF
    Scott Sagel; Fiscal Year: 2007
    ..In addition, he will actively participate and train in the Pediatric GCRC, and frequently interact with his sponsor, mentors, and collaborators. ..
  7. Hu1D10 in CLL: CLINICAL AND LABORATORY STUDIES
    John Byrd; Fiscal Year: 2006
    ..abstract_text> ..
  8. Role of Cytokines in Two Hit Organ Injury
    Jean Nemzek; Fiscal Year: 2006
    ..Successful completion of these aims could impact current two hit theories and use of immune therapy in septic patients exposed to additional inflammatory insults. ..
  9. Interventions for Tobacco Dependent Adolescents
    Dorothy Hatsukami; Fiscal Year: 2005
    ....
  10. TREATMENT OF SMOKELESS TOBACCO USERS
    Dorothy Hatsukami; Fiscal Year: 2008
    ..PERFORMANCE SITE ========================================Section End=========================================== ..
  11. TOBACCO EXPOSURE REDUCTION
    Dorothy Hatsukami; Fiscal Year: 2008
    ..The results of research from this TTURC will provide the scientific basis for urgent policy, public education, and regulatory efforts to reduce tobacco harm. ..
  12. Building a Latino admixture map & pilot study to find Type 2 Diabetes risk
    David Reich; Fiscal Year: 2007
    ..The study will also enable larger admixture mapping studies with many thousands of patients with Type 2 Diabetes, which we would like to pursue both in U.S. Latino and in Latin American populations. [unreadable] [unreadable] [unreadable]..
  13. Associating genetic variation to resistance to severe malaria in East Africa
    David Reich; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  14. Mechanisms of Vascular Injury in the preterm lung
    Suhas Kallapur; Fiscal Year: 2006
    ..The experimental design in this proposal incorporates challenging but, particularly in this environment achievable goals that will provide important knowledge in the pathogenesis of bronchopulmonary dysplasia. ..
  15. RISK FACTORS IN BRONCHOPULMONARY DYSPLASIA
    Mari Palta; Fiscal Year: 2006
    ....
  16. Pharmacogenetics of Asparaginase-Induced Pancreatitis
    Lewis Silverman; Fiscal Year: 2007
    ..abstract_text> ..
  17. Neurotoxicity of Chronic Exposure to Air Pollution
    Lilian Calderon Garciduenas; Fiscal Year: 2006
    ..abstract_text> ..
  18. GENETIC, BIOLOGIC, & IMMUNOLOGIC DETERMINANTS OF ASTHMA
    Mario Castro; Fiscal Year: 2006
    ..abstract_text> ..
  19. Use of symbiotics to reduce urinary oxalate excretion
    JOHN LIESKE; Fiscal Year: 2007
    ..If results are positive, treatment for calcium oxalate kidney stones could be revolutionized. ..
  20. Psychological stress, cortisol, and B lymphocyte decrements
    Bonnie McGregor; Fiscal Year: 2007
    ..The present study will begin to elucidate the mechanism by which psychological stress impairs immune response to vaccines. [unreadable] [unreadable] [unreadable]..
  21. Asthma Clinical Research Network-Washington University
    Mario Castro; Fiscal Year: 2007
    ..We propose that it is only through such a collaboration that important questions regarding current and novel therapies and management of asthma can be answered. ..
  22. Mechanisms of methyl dithiocarbamate immunotoxicity
    Stephen B Pruett; Fiscal Year: 2010
    ..It is also expected that the detailed study of three important mechanisms of action, which will be examined in each aim, can be generalized to other situations or toxicants that alter these parameters. ..
  23. Endotoxin-induced Uveitis Revisited
    James T Rosenbaum; Fiscal Year: 2010
    ..Future studies can buil d on these observations to test anti-inflammtory molecules induced by endotoxin as these molecules are potentially useful in the treatment of uveitis and other inflammations. ..
  24. HIV-Hepatitis C Virus Interactions and Pathogenesis
    Raymond T Chung; Fiscal Year: 2010
    ..These studies will shed considerable light on HIV-HCV pathogenic interactions and offer a means of productively disrupting these interactions. ..
  25. Th2 effects on eicosanoid pathways: implications for altered innate responses in
    Sally E Wenzel; Fiscal Year: 2010
    ..These three aims should provide new insights into how relationships between innate and adaptive/allergic immune responses influence inflammatory/repair, and finally clinical outcomes in chronic and acute asthma. ..
  26. Towards a better understanding of work-aggravated asthma
    Catherine Lemiere; Fiscal Year: 2009
    ..The occurrence of asthma exacerbations will be recorded. The economic impact of WAA will be assessed in terms of work disability and use of health resources and compared with OA and asthma without OA not WAA. ..
  27. Cytokine-CRH Interactions in IFN-alfa-Induced Depression
    Charles Raison; Fiscal Year: 2009
    ..abstract_text> ..
  28. Air Pollution and Central Nervous System Disease
    Lilian Calderon Garciduenas; Fiscal Year: 2008
    ..The Award will give me the opportunity to build new skills in 4 areas: Molecular Biology, DNA Damage, Developmental / Neurodegenerative Neuropathology, and to gain experience in grantsmanship. [unreadable] [unreadable]..
  29. IMMUNOLOGY/MOLECULAR BIOLOGY TRAINING IN OPHTHALMOLOGY
    James Rosenbaum; Fiscal Year: 2007
    ..The quality of the institution, the talents of the specific faculty, the abilities of the applicant pool, and the proven success of the program areadditional strengths of this application. ..
  30. Ras Pathway Mutations in Human Leukemia
    Mignon Loh; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  31. CHEMOTACTIC FACTORS IN ANIMAL MODELS OF UVEITIS
    James Rosenbaum; Fiscal Year: 2008
    ..We believe that these aims are novel, innovative, especially suited to the skills and achievements demonstrated by our laboratory, and highly relevant to clarifying the pathogenesis of anterior uveitis. ..
  32. Investigation of Nod2: Implications for Uveitis
    Holly Rosenzweig; Fiscal Year: 2008
    ..Together, these studies will provide valuable new information on how Nod2 is involved in autoimmunity and the pathogeneis of uveitis. ..
  33. Nephrolithiasis and Chronic Kidney Disease
    JOHN LIESKE; Fiscal Year: 2007
    ..This will gain additional urgency if in fact we demonstrate that NL is a significant risk factor for CKD. [unreadable] [unreadable] [unreadable]..
  34. Linkage Studies of Quantitative Ocular Traits
    Barbara Klein; Fiscal Year: 2006
    ..Subsequent follow-up with fine mapping of areas of interest in the genome is planned. ..
  35. Eosinophil Granule Proteins and Their Functions
    Gerald Gleich; Fiscal Year: 2006
    ..Overall, these studies will expand our knowledge of the molecules composing the eosinophil granule and provide new tools to dissect eosinophil function in disease. ..
  36. Healing Touch and Immunity in Advanced Cervical Cancer
    Susan Lutgendorf; Fiscal Year: 2002
    ....
  37. SIMIAN AIDS: SOCIAL STRESS, ENDOCRINE & IMMUNE FUNCTION
    John Capitanio; Fiscal Year: 2004
    ..abstract_text> ..
  38. Arsenic Trioxide Down-Regulates STAT3 Activity in AML
    Meir Wetzler; Fiscal Year: 2004
    ..In addition, we will attempt to identify the mode by which ATO controls the activity of STAT3 and how this effect alters the gene profile patterns and induces apoptosis. ..
  39. Family Clustering of Incidence & Progression of Cataract
    Barbara Klein; Fiscal Year: 2003
    ..We currently have no funds to support the proposed analyses. We believe this project offers the possibility of examining important hypotheses in a large group of families in a population-based framework. ..
  40. NOVEL ANIMAL MODELS OF HCV-RELATED HEPATOCARCINOGENESIS
    Raymond Chung; Fiscal Year: 2003
    ..Together, these models will help provide insights into the factors responsible for this devastating complication of chronic HCV infection. ..
  41. RISK FACTORS FOR ATHEROGENESIS IN TYPE 1 DIABETES
    Mari Palta; Fiscal Year: 2003
    ..Such information is critical in directing further efforts toward primary prevention of atherosclerosis in individuals with Type 1 diabetes mellitus. ..
  42. IMPROVING THE TREATMENT AND CONTROL OF HYPERTENSION
    Karen Margolis; Fiscal Year: 2003
    ..abstract_text> ..
  43. EFFECTS OF MISSPECIFICATION IN LONGITUDINAL MODELS
    Mari Palta; Fiscal Year: 2003
    ....
  44. FUSION GENES IN LEUKEMIA--DETERMINING SIGNIFICANCE
    Mignon Loh; Fiscal Year: 2003
    ..abstract_text> ..
  45. PROGRESSION OF AORTIC ATHEROMA IN STROKE/TIA PATIENTS
    Souvik Sen; Fiscal Year: 2004
    ..Designing of future placebo controlled prospective studies aimed at investigating measures that may be used to treat AA in stroke/TIA patients. ..
  46. CELLULAR IMMUNE RESPONSE IN CHRONIC HEPATITIS C
    David Nelson; Fiscal Year: 2003
    ..These studies will provide insight into basic immunologic principles associated with the host's immune response to this viral infection, as well as provide the basis for new interventional strategies. ..
  47. POST TRANSCRIPTIONAL CONTROL OF THE HUMAN N MYC GENE
    William Carroll; Fiscal Year: 2002
    ....
  48. TRANSFORMING GROWTH FACTOR BETA IN OXIDANT LUNG INJURY
    MICHAEL O REILLY; Fiscal Year: 2002
    ..These studies are significant because understanding how ROS injure and kill pulmonary epithelial cells is critically important for improving clinical therapies that rely on supplemental oxygen. ..
  49. PEDIATRIC ONCOLOGY GROUP
    Yaddanapudi Ravindranath; Fiscal Year: 2002
    ....
  50. Role of Nanobacteria in Human Calcifying Disease
    JOHN LIESKE; Fiscal Year: 2004
    ..abstract_text> ..
  51. Healing Touch, Immunity, and Fatigue in Breast Cancer
    Susan Lutgendorf; Fiscal Year: 2004
    ....
  52. NOVEL INHIBITOR OF CRYSTAL ADHESION TO RENAL CELLS
    JOHN LIESKE; Fiscal Year: 2004
    ..Achieving these specific aims will provide new knowledge about mechanisms that mediate stone formation, and provide a rational basis for design of novel strategies to treat and/or prevent this disease. ..
  53. Chemokines and microglia in Alzheimer's disease
    Joseph El Khoury; Fiscal Year: 2005
    ....
  54. Airway Remodeling in Severe Asthma
    Mario Castro; Fiscal Year: 2005
    ..The identification of the potential variables associated with remodeling and severe asthma will help identify individuals at risk who would benefit from specific targeted therapy. ..
  55. Mechanisms of Immunotoxcity of Chemical Stressors
    Stephen Pruett; Fiscal Year: 2005
    ....
  56. Inducible NOS as a Treatment Target in CLL
    J Weinberg; Fiscal Year: 2005
    ....
  57. Neuroimmune Modulation of Virus Immunity In Aging
    Raymond Stowe; Fiscal Year: 2002
    ..These data will subsequently be used to support an R01 application to develop a mechanistic investigation on how neuroendocrine hormones modulate herpesvirus-specific immunity in the elderly. ..
  58. Anterior Uveal Dendritic Cells
    James Rosenbaum; Fiscal Year: 2004
    ..These studies will clarify the function of the immune system within the eye and may suggest novel therapeutic approaches in the treatment of uveitis. ..
  59. TGF-BETA AND MATRIX METALLOPROTEINASES IN AIRWAY REPAIR
    Sally Wenzel; Fiscal Year: 2002
    ..abstract_text> ..
  60. Oxalate-Induced Renal Scarring and Crystal Retention
    JOHN LIESKE; Fiscal Year: 2003
    ..Dr. Luis Juncos has extensive experience studying the regulation of renal blood flow in vivo, and will be critical in our efforts to develop the constant infusion model of hyperoxalemia and hyperoxaluria. ..
  61. Monocyte / Macrophage TLR4 Expression and Signaling: A Link between Obesity and C
    Brian McFarlin; Fiscal Year: 2008
    ..The primary purpose of this investigation is to determine if obesity status alters TLR4 signaling and/or inflammatory cytokine production in blood monocyte and adipose tissue macrophage. [unreadable] [unreadable] [unreadable]..
  62. Defibrotide for the treatment of severe hepatic veno-cc*
    Paul Richardson; Fiscal Year: 2007
    ..Abstract Not Provided ..
  63. BEHAVIORAL AND IMMUNOLOGICAL FACTORS IN CORONARY DISEASE
    Willem Kop; Fiscal Year: 2005
    ....
  64. Treatment and Costs of Neonatal Jaundice in a Large HMO
    Thomas Newman; Fiscal Year: 2007
    ..The results of this study will help make neonatal jaundice guidelines and treatment decisions more evidence based. [unreadable] [unreadable] [unreadable]..
  65. Regulation of Pulmonary Host Defense by Leptin
    Peter Mancuso; Fiscal Year: 2010
    ..They will also test the use of exogenous leptin as an adjunctive therapeutic agent in the treatment of pneumococcal pneumonia. ..
  66. Murine CMV Pneumonitis in Allogeneic BMT
    Oliver Oakley; Fiscal Year: 2005
    ..This research will also provide the opportunity for students to participate actively in the solution to an important clinical problem. ..
  67. Monocyte Biology and Biodefense
    DOUGLAS DREVETS; Fiscal Year: 2005
    ..These data will then catalyze development of rational therapies to improve host defenses against severe and overwhelming infection by category A and B intracellular bacterial pathogens. ..
  68. Mechanisms for Reduced Limb Perfusion with Human Aging
    DOUGLAS SEALS; Fiscal Year: 2002
    ..The expected results should provide new insight into the effects of age and gender on basal limb perfusion in adult humans and the underlying mechanisms. ..
  69. Molecular and Cellular Analyses of Aquaporins in Lung
    LANDON KING; Fiscal Year: 2005
    ..These studies should provide insight into mechanisms regulating expression of AQP1 and AQP5, and establish a framework from which to better understand their role in the pathophysiology of the respiratory tract. ..
  70. Human Aging and B-adrenergic Modulation of Thermogenesis
    DOUGLAS SEALS; Fiscal Year: 2009
    ..The proposed research also will provide novel insight into the integrative (whole-body to molecular/genetic) physiological mechanisms underlying these effects. ..
  71. Hormone Replacement Therapy, SERMs & Leg Blood Flow in Postmenopausal Women
    DOUGLAS SEALS; Fiscal Year: 2007
    ..The results should provide new insight into the effects of HRT and a SERM for augmenting LBF and LVC in estrogen deficient postmenopausal women and the underlying physiological mechanisms. ..
  72. Hopkins Bayview Confocal Imaging System
    LANDON KING; Fiscal Year: 2007
    ..Collectively, these diseases represent a significant burden on the health care system and account for a large fraction of deaths in the United States every year. [unreadable] [unreadable] [unreadable]..
  73. MOLECULAR AND CELLULAR ANALYSIS OF AQUAPORIN 1 IN LUNG
    LANDON KING; Fiscal Year: 2002
    ..These studies should enhance the understanding of the molecular mechanisms regulating lung water homeostasis. ..