Genomes and Genes
Summary: The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells.
Publications305 found, 100 shown here
- Neutrophil-lymphocyte ratio as a prognostic factor in colorectal cancerS R Walsh
Department of Colorectal Surgery, West Suffolk Hospital NHS Trust, UK
J Surg Oncol 91:181-4. 2005..Simple methods to identify colorectal cancer patients at risk of recurrence are needed. This study aimed to determine if neutrophil-to-lymphocyte ratio (NLR) predicts survival in colorectal cancer patients...
- Ratio of neutrophil to lymphocyte counts--rapid and simple parameter of systemic inflammation and stress in critically illR Zahorec
Department of Anaesthesiology and Intensive Care Medicine, St Elizabeth Cancer Institute, Bratislava
Bratisl Lek Listy 102:5-14. 2001..We investigate whether serial examination of white blood cell counts may reflect and clarify the immune response to stressful events in critically ill patients...
- Neutrophil/lymphocyte ratio and its association with survival after complete resection in non-small cell lung cancerKhaled M Sarraf
Academic Division of Thoracic Surgery, Royal Brompton Hospital, London, United Kingdom
J Thorac Cardiovasc Surg 137:425-8. 2009..We sought to determine factors associated with increasing neutrophil/lymphocyte ratios and the stage-adjusted prognostic effect in patients undergoing resection for non-small cell lung cancer...
- A comparison of inflammation-based prognostic scores in patients with cancer. A Glasgow Inflammation Outcome StudyMichael J Proctor
University Department of Surgery, Faculty of Medicine, University of Glasgow, Royal Infirmary, Glasgow, UK
Eur J Cancer 47:2633-41. 2011..The aim of the present study was to compare the prognostic value of these scores...
- Asthma exacerbations and sputum eosinophil counts: a randomised controlled trialRuth H Green
Institute for Lung Health, Department of Respiratory Medicine and Thoracic Surgery, Glenfield Hospital, LE3 9PQ, Leicester, UK
Lancet 360:1715-21. 2002..We aimed to assess whether a management strategy that minimises eosinophilic inflammation reduces asthma exacerbations compared with a standard management strategy...
- High white blood cell count is associated with a worsening of insulin sensitivity and predicts the development of type 2 diabetesBarbora Vozarova
Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
Diabetes 51:455-61. 2002..These findings are consistent with the hypothesis that a chronic activation of the immune system may play a role in the pathogenesis of type 2 diabetes...
- Pretreatment neutrophil-to-lymphocyte ratio as an independent predictor of recurrence in patients with nonmetastatic renal cell carcinomaYoshio Ohno
Department of Urology, Tokyo Medical University, Tokyo, Japan
J Urol 184:873-8. 2010..We investigated the prognostic significance of the neutrophil-to-lymphocyte ratio to predict recurrence in patients with nonmetastatic renal cell carcinoma...
- The baseline ratio of neutrophils to lymphocytes is associated with patient prognosis in advanced gastric cancerTakeharu Yamanaka
Institute for Clinical Research, National Kyushu Cancer Center, Fukuoka, Japan
Oncology 73:215-20. 2007..The objective of our study was to determine the prognostic implications of the N/L ratio in the peripheral blood of gastric cancer patients...
- Usefulness of neutrophil to lymphocyte ratio in predicting short- and long-term mortality after non-ST-elevation myocardial infarctionBasem Azab
Department of Internal Medicine, Staten Island University Hospital, Staten Island, New York, NY, USA
Am J Cardiol 106:470-6. 2010..7. We strongly suggest the use of NLR rather than other leukocyte parameters (e.g., total white blood cell count) in risk stratification of the NSTEMI population...
- The association of total and differential white blood cell count with metabolic syndrome in type 2 diabetic patientsWan Sub Shim
Department of Internal Medicine, Yonsei University College of Medicine, Seodaemoon ku, Seoul, Republic of Korea
Diabetes Res Clin Pract 73:284-91. 2006..We investigated the relation between total and differential white blood cell (WBC) count and metabolic syndrome (MS) in type 2 diabetic patients...
- White blood cell counts and malariaF Ellis McKenzie
Fogarty International Center, National Institutes of Health, Bethesda, Maryland 20892, USA
J Infect Dis 192:323-30. 2005..For instance, in the present study, use of this conventional approach would have overestimated average asexual parasite densities in the P. falciparum-infected patients in Thailand by nearly one-third...
- Negative impact of neutrophil-lymphocyte ratio on outcome after liver transplantation for hepatocellular carcinomaKarim J Halazun
Department of Organ Transplantation, New York Presbyterian Hospital, Columbia University, MHB 7GS 313, 177 Ft Washington Avenue, New York, NY 10032, USA
Ann Surg 250:141-51. 2009..We aimed to determine whether NLR predicts outcome in patients undergoing OLT for HCC...
- Longitudinal study on white blood cell count and the incidence of metabolic syndromeKeiichi Odagiri
YAMAHA Health Care Center, Japan
Intern Med 50:2491-8. 2011..However, few cohort studies have examined the role of WBC in the development of MetS. We hypothesized that WBC is associated with the future development of MetS, and investigated the longitudinal incidence of MetS in healthy workers...
- The relationships between body composition and the systemic inflammatory response in patients with primary operable colorectal cancerColin H Richards
University Department of Surgery, Glasgow Royal Infirmary, Glasgow, United Kingdom
PLoS ONE 7:e41883. 2012..The aim of the present study was to examine the relationships between CT measured parameters of body composition and the systemic inflammatory response in patients with primary operable colorectal cancer...
- High blood neutrophil-to-lymphocyte ratio is an indicator of poor prognosis in malignant mesothelioma patients undergoing systemic therapySteven C H Kao
Department of Medical Oncology, Sydney Cancer Centre, Australia
Clin Cancer Res 16:5805-13. 2010..We have investigated blood neutrophil-to-lymphocyte ratio (NLR), an index of systemic inflammation, as a prognostic factor in MM patients...
- Leukocyte count as an independent predictor of recurrent ischemic eventsArmin J Grau
Neurologische Klinik, Klinikum der Stadt Ludwigshafen a Rh, Bremserstr 70, D 67063 Ludwigshafen, Germany
Stroke 35:1147-52. 2004..We investigated whether leukocyte and differential counts predict recurrent events and ischemic events in high-risk populations, and whether such events are preceded by acutely exacerbated inflammation...
- Utility of the neutrophil to lymphocyte ratio in predicting long-term outcomes in acute decompensated heart failureShanmugam Uthamalingam
Massachusetts General Hospital, Boston, USA
Am J Cardiol 107:433-8. 2011..NLR is a readily available inexpensive marker to aid in the risk stratification of patients with ADHF...
- A derived neutrophil to lymphocyte ratio predicts survival in patients with cancerM J Proctor
University Department of Surgery, Faculty of Medicine, Royal Infirmary, University of Glasgow, Glasgow G31 2 ER, UK
Br J Cancer 107:695-9. 2012..The aim of the present study was to compare the prognostic value of the NLR with a derived score (dNLR), composed of white cell and neutrophil counts...
- The nature of small-airway obstruction in chronic obstructive pulmonary diseaseJames C Hogg
University of British Columbia, the Centre for Cardiovascular and Pulmonary Research, and St Paul s Hospital, Vancouver, Canada
N Engl J Med 350:2645-53. 2004..We examined the evolution of the pathological effects of airway obstruction in patients with COPD...
- Impact of immune parameters on long-term survival in metastatic renal cell carcinomaFrede Donskov
Department of Oncology, Aarhus University Hospital, Aarhus C, Denmark
J Clin Oncol 24:1997-2005. 2006..The purpose of this study was to evaluate the impact of immunologic prognostic factors in combination with established clinical prognostic factors in patients with metastatic renal cell carcinoma (mRCC)...
- Association of peripheral total and differential leukocyte counts with metabolic syndrome and risk of ischemic cardiovascular diseases in patients with type 2 diabetes mellitusJack C R Tsai
Department of Clinical Research, Pingtung Christian Hospital, Pingtung, 90000, Taiwan
Diabetes Metab Res Rev 23:111-8. 2007....
- Comparison of the prognostic value of selected markers of the systemic inflammatory response in patients with colorectal cancerE F Leitch
1University Department of Surgery, Royal Infirmary, Glasgow G31 2ER, UK
Br J Cancer 97:1266-70. 2007..An acute-phase protein-based prognostic score, the mGPS, appears to be a superior predictor of survival compared with the cellular components of the systemic inflammatory response...
- Changes in white blood cells and platelets in children with falciparum malaria: relationship to disease outcomeShamez Ladhani
Centre for Geographical Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
Br J Haematol 119:839-47. 2002..Thus, leucocytosis was associated with both severity and mortality in children with falciparum malaria, irrespective of bacteraemia, whereas thrombocytopenia, although very common, was not associated with adverse outcome...
- Prognostic value of pre-treatment circulating monocyte count in patients with cervical cancer: comparison with SCC-Ag levelYoo Young Lee
Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
Gynecol Oncol 124:92-7. 2012..We investigated the role of pre-treatment circulating monocyte count for cancer specific survival in cervical squamous cell carcinoma patients comparing with pre-treatment squamous cell carcinoma-related antigen (SCC-Ag) level...
- Differential white blood cell count and type 2 diabetes: systematic review and meta-analysis of cross-sectional and prospective studiesEffrossyni Gkrania-Klotsas
MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, United Kingdom
PLoS ONE 5:e13405. 2010..However, the association has not been systematically investigated...
- Black-white divergence in the relation of white blood cell count to metabolic syndrome in preadolescents, adolescents, and young adults: the Bogalusa Heart StudyWei Chen
Department of Epidemiology, Tulane Center for Cardiovascular Health, Tulane University, New Orleans, Louisiana, USA
Diabetes Care 33:2474-6. 2010..To examine the association between white blood cell (WBC) count and metabolic syndrome (MetS) by growth periods in black versus white individuals in the general population...
- Lymphocytopenia and neutrophil-lymphocyte count ratio predict bacteremia better than conventional infection markers in an emergency care unitCornelis P C de Jager
Department of Emergency Medicine and Intensive Care, Jeroen Bosch Ziekenhuis, Tolbrugstraat 11, 5200 ME s Hertogenbosch, The Netherlands
Crit Care 14:R192. 2010..Likewise, the neutrophil-lymphocyte count ratio (NLCR) has been shown a simple promising method to evaluate systemic inflammation in critically ill patients...
- The absolute monocyte count is associated with overall survival in patients newly diagnosed with follicular lymphomaRyan A Wilcox
Department of Internal Medicine, Division of Hematology Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI 48109 5948, USA
Leuk Lymphoma 53:575-80. 2012..These results further support the central role of non-neoplastic myeloid-lineage cells in follicular lymphoma biology...
- Pretreatment neutrophil count as an independent prognostic factor in advanced non-small-cell lung cancer: an analysis of Japan Multinational Trial Organisation LC00-03Satoshi Teramukai
Department of Clinical Trial Design and Management, Translational Research Center, Kyoto University Hospital, Kyoto 606 8507, Japan
Eur J Cancer 45:1950-8. 2009..Neutrophil count is easily measured at low cost, and it may be a useful indicator of patient prognosis...
- Clinical risk factors for severe Clostridium difficile-associated diseaseTimothy J Henrich
Division of Infectious Diseases, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Emerg Infect Dis 15:415-22. 2009..05): age >70 years (odds ratio [OR] 3.35), maximum leukocyte count >20,000 cells/mL (OR 2.77), minimum albumin level <2.5 g/dL (OR 3...
- Comparison of the prognostic values of various inflammation based factors in patients with pancreatic cancerDe Shen Wang
State Key Laboratory of Oncology in South China, Sun Yat sen University Cancer Center, 651 Dong Feng Road East, Guangzhou, 510060, China
Med Oncol 29:3092-100. 2012..200 months (p < 0.001). Our study demonstrates that elevated NLR is superior to the mGPS, PI, PLR and PNI for prognostication in patients with pancreatic cancer...
- Followup of neutrophil-to-lymphocyte ratio and recurrence of clear cell renal cell carcinomaYoshio Ohno
Department of Urology, Tokyo Medical University, Tokyo, Japan
J Urol 187:411-7. 2012..However, the clinical implication of a posttreatment change in the neutrophil-to-lymphocyte ratio in patients with cancer remains unclear...
- Can neutrophil-to-lymphocyte ratio predict the survival of colorectal cancer patients who have received curative surgery electively?Sum Fu Chiang
Division of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital, 5 Fu Hsing St, Kuei Shan Hsiang, Taoyuan, Linkou, Taiwan
Int J Colorectal Dis 27:1347-57. 2012..We evaluated the effect of neutrophil-to-lymphocyte ratio (NLR) on disease-free survival in patients with stages I to III colorectal cancer (CRC)...
- Population-based hematologic and immunologic reference values for a healthy Ugandan populationEric S Lugada
Center for International Health, University of Bergen, Bergen, Norway
Clin Diagn Lab Immunol 11:29-34. 2004..These differences could influence the decision to initiate antiretroviral therapy among children infected with HIV...
- High preoperative neutrophil-lymphocyte ratio predicts poor survival in patients with gastric cancerHideaki Shimada
Department of Gastroenterological Surgery, Chiba Cancer Center, Chiba, Japan
Gastric Cancer 13:170-6. 2010..An elevated NLR has been reported to be a prognostic indicator in some malignant tumors. The aim of this study was to evaluate the clinical significance of the preoperative NLR in patients with primary gastric cancer...
- Relation between lymphopenia and bacteraemia in UK adults with medical emergenciesD H Wyllie
Nuffield Departments of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
J Clin Pathol 57:950-5. 2004..To determine the relevance of lymphopenia to the diagnosis of bacteraemia in patients admitted with medical emergencies, relative to peripheral blood white cell count and neutrophilia...
- The effect of abrupt weaning of suckler calves on the plasma concentrations of cortisol, catecholamines, leukocytes, acute-phase proteins and in vitro interferon-gamma productionM C Hickey
Teagasc, Grange Research Centre, Dunsany, Co Meath, Ireland
J Anim Sci 81:2847-55. 2003..Abrupt weaning increased plasma cortisol and noradrenaline concentrations that were accompanied by attenuation of in vitro interferon-gamma production to novel mitogen and antigen complexes up to 7 d after weaning...
- Which white blood cell subtypes predict increased cardiovascular risk?Benjamin D Horne
Cardiovascular Department, LDS Hospital, Salt Lake City, Utah 84143, USA
J Am Coll Cardiol 45:1638-43. 2005..We sought to determine the predictive ability of total white blood cell (WBC) count and its subtypes for risk of death or myocardial infarction (MI)...
- Leukocyte count as a predictor of cardiovascular events and mortality in postmenopausal women: the Women's Health Initiative Observational StudyKaren L Margolis
Hennepin County Medical Center, and Berman Center for Outcomes and Clinical Research, 825 S Eighth Street, Minneapolis, MN 55404, USA
Arch Intern Med 165:500-8. 2005Increasing evidence supports a role for inflammation in the atherosclerotic process. The role of the leukocyte count as an independent predictor of risk of a first cardiovascular disease (CVD) event remains uncertain...
- Polymorphonuclear neutrophils and cancer: intense and sustained neutrophilia as a treatment against solid tumorsJuan Carlos Souto
Department of Hematology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Med Res Rev 31:311-63. 2011..This antitumoral role of neutrophils may provide new avenues for the clinical treatment of cancer...
- Relative elevation in baseline leukocyte count predicts first cerebral infarctionM S V Elkind
Department of Neurology, Columbia University College of Physicians and Surgeons, Joseph Mailman School of Public Health, New York, NY, USA
Neurology 64:2121-5. 2005..Atherosclerosis is an inflammatory disease, and leukocyte levels are associated with future risk of ischemic cardiac disease...
- Synovial fluid leukocyte count and differential for the diagnosis of prosthetic knee infectionAndrej Trampuz
Division of Infectious Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Am J Med 117:556-62. 2004..Our aim was to define cutoff values for synovial fluid leukocyte count and neutrophil percentage for differentiating aseptic failure and prosthetic joint infection.
- An early and sustained peripheral inflammatory response in acute ischaemic stroke: relationships with infection and atherosclerosisHedley C A Emsley
University of Manchester, Manchester, UK
J Neuroimmunol 139:93-101. 2003....
- Leukocyte count is associated with aortic arch plaque thicknessMitchell S V Elkind
Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, USA
Stroke 33:2587-92. 2002b>Leukocyte count has been associated with cardiovascular and cerebrovascular disease, including carotid plaque thickness, in several studies...
- The neutrophil-lymphocyte count ratio in patients with community-acquired pneumoniaCornelis P C de Jager
Department of Emergency Medicine and Intensive Care, Jeroen Bosch Ziekenhuis, s Hertogenbosch, The Netherlands
PLoS ONE 7:e46561. 2012..The neutrophil-lymphocyte count ratio (NLCR) has been identified as a predictor of bacteremia in medical emergencies. The aim of this study was to investigate the value of the NLCR in patients with community-acquired pneumonia (CAP)...
- Automated blood cell counts: state of the artMauro Buttarello
Department of Laboratory Medicine, University Hospital of Padova, Padova, Italy
Am J Clin Pathol 130:104-16. 2008....
- Cytokine response to diabetic ketoacidosis (DKA) in children with type 1 diabetes (T1DM)Kyriaki Karavanaki
Diabetic Clinic, B Paediatric Department, University of Athens Medical School, P and A Kyriakou Children s Hospital, Athens, Greece
Endocr J 58:1045-53. 2011..These changes may be responsible for increased capillary perturbation, which could lead to the subsequent development of acute DKA complications...
- Elevated systemic neutrophil count in diabetic retinopathy and diabetes: a hospital-based cross-sectional study of 30,793 Korean subjectsSe Joon Woo
Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital SNUBH, Seongnam, Korea
Invest Ophthalmol Vis Sci 52:7697-703. 2011..To evaluate the association between systemic parameters including inflammatory markers and diabetic retinopathy (DR)...
- Elevated white blood cell count and carotid plaque thickness : the northern manhattan stroke studyM S Elkind
Department of Neurology, Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
Stroke 32:842-9. 2001Elevated leukocyte count has been associated with cardiovascular and cerebrovascular disease in several epidemiological studies...
- Prospective study of hemostatic factors and incidence of coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) StudyA R Folsom
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55454 1015, USA
Circulation 96:1102-8. 1997..Although hemostatic factors contribute to acute coronary syndromes and atherogenesis, few studies have prospectively evaluated the association between multiple hemostatic factors and coronary heart disease incidence...
- White blood cell count is associated with carotid and femoral atherosclerosisEmilio Ortega
Endocrinology and Nutrition Service, Institut d Investigacions Biomèdiques August Pi Sunyer, Hospital Clinic, Barcelona, Spain
Atherosclerosis 221:275-81. 2012..Ultrasound imaging allows measurement of intima-media thickness (IMT) and plaque. We investigated the association between inflammatory markers and carotid and femoral atherosclerosis...
- The prevalence of metabolic syndrome and diabetes increases through the quartiles of white blood cell count in Japanese men and womenEiji Oda
Medical Check up Center, Tachikawa Medical Center, Nagaoka
Intern Med 48:1127-34. 2009..Low-grade systemic inflammation is proposed as a component of metabolic syndrome (MS) and is reported as a predictor of diabetes. We studied the association between white blood cell count (WBC) and MS and diabetes in Japanese men and women...
- Cytokines in rats experimentally infected with Trypanosoma evansiFrancine C Paim
Laboratory of Veterinary Clinical Analysis LACVet, Federal University of Santa Maria, 97105 900 Santa Maria, RS, Brazil
Exp Parasitol 128:365-70. 2011..These results suggest a synergism among IL-1, TNF-α and IFN-γ contributing to the development of anemia. This increase is associated with the regulation of immune responses against the parasite...
- Association of fibrinogen, C-reactive protein, albumin, or leukocyte count with coronary heart disease: meta-analyses of prospective studiesJ Danesh
Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Clinical Medicine, University of Oxford, England
JAMA 279:1477-82. 1998..A large number of epidemiologic studies have reported on associations between various "inflammatory" factors and coronary heart disease (CHD)...
- Comparison of alanine aminotransferase, white blood cell count, and uric acid in their association with metabolic syndrome: a study of Korean adultsYang Ho Kang
Division of Endocrinology and Metabolism, Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea
Endocr J 55:1093-102. 2008..Among three markers, in overlap the multiple risk factors, ALT might have a strong association with metabolic syndrome in Korean adults...
- Outcome predictability of biomarkers of protein-energy wasting and inflammation in moderate and advanced chronic kidney diseaseCsaba P Kovesdy
Salem VA Medical Center, Salem, VA 24153, USA
Am J Clin Nutr 90:407-14. 2009..Markers of protein-energy wasting (PEW) and inflammation are common in chronic kidney disease (CKD) and are among the strongest predictors of mortality in dialysis patients...
- Comparison of four hematology analyzers, CELL-DYN Sapphire, ADVIA 120, Coulter LH 750, and Sysmex XE-2100, in terms of clinical usefulnessS H Kang
Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
Int J Lab Hematol 30:480-6. 2008..0%); and LH 750 showed the highest sensitivity for Nucleated RBC flag (75.0%). Our results demonstrate that the four analyzers are comparable in overall performance...
- Depression and inflammation in patients with coronary heart disease: findings from the Heart and Soul StudyMary A Whooley
Department of Veterans Affairs Medical Center, San Francisco, California University of California, San Francisco, CA 94121, USA
Biol Psychiatry 62:314-20. 2007..However, studies investigating the link between depression and inflammation in patients with established CHD have produced inconclusive results...
- Musculoskeletal manifestations in pediatric acute leukemiaRiccardo Sinigaglia
Sandro Agostini Spine Surgery Unit, Padua University Hospital, Padua, Italy
J Pediatr Orthop 28:20-8. 2008..In children, acute leukemia (AL) at presentation can mimic several orthopaedic pathologies, so that a variable delay of the correct diagnosis is often reported...
- Differential leucocyte count and the risk of future coronary artery disease in healthy men and women: the EPIC-Norfolk Prospective Population StudyJ S Rana
Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
J Intern Med 262:678-89. 2007..There is paucity of data on the differential leucocyte count and its relationship with the risk of CHD and CVD...
- Effect of serotypes on clinical manifestations of dengue fever in adultsJih Jin Tsai
Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
J Microbiol Immunol Infect 42:471-8. 2009..However, it is unclear whether different dengue virus serotypes (DENV) are associated with different clinical manifestations and outcomes. This study investigated the association between viral serotype and clinical manifestations of DF...
- Antiinflammatory effects of salmeterol/fluticasone propionate in chronic obstructive lung diseaseNeil C Barnes
Department of Respiratory Medicine, London Chest Hospital, London, UK
Am J Respir Crit Care Med 173:736-43. 2006..No currently available treatment is reported to reduce the exaggerated airway wall inflammation of chronic obstructive pulmonary disease...
- Serum and ascitic procalcitonin levels in cirrhotic patients with spontaneous bacterial peritonitis: diagnostic value and relationship to pro-inflammatory cytokinesA Viallon
Emergency and Intensive Care Units, Bellevue Hospital, Saint Etienne, France
Intensive Care Med 26:1082-8. 2000..To assess the potential role of procalcitonin and pro-inflammatory cytokines, TNF-alpha, and IL-6, in the diagnosis of spontaneous bacterial peritonitis (SBP)...
- Relationship of monocyte count and peripheral arterial disease: results from the National Health and Nutrition Examination Survey 1999-2002Khurram Nasir
Cardiology Division, Department of Medicine, Johns Hopkins University, Baltimore, MD 21287 0409, USA
Arterioscler Thromb Vasc Biol 25:1966-71. 2005....
- Monocyte subtypes predict clinical course and prognosis in human strokeXabier Urra
Functional Unit of Cerebrovascular Diseases, Hospital Clinic, Barcelona, Spain
J Cereb Blood Flow Metab 29:994-1002. 2009..Therefore, monitoring of monocyte subtypes may emerge as a useful tool at the bedside for stroke patients...
- Clinical, radiologic, and induced sputum features of chronic obstructive pulmonary disease in nonsmokers: a descriptive studySurinder S Birring
Department of Respiratory Medicine, Radiology, and Respiratory Physiology, and Leicester Children s Asthma Centre, Institute for Lung Health, Glenfield Hospital, Leicester, United Kingdom
Am J Respir Crit Care Med 166:1078-83. 2002..Further investigation of this group may disclose novel mechanisms of fixed airflow obstruction...
- Periprosthetic infection: what are the diagnostic challenges?Javad Parvizi
J Bone Joint Surg Am 88:138-47. 2006
- Leukocyte count and coronary heart disease: implications for risk assessmentMohammad Madjid
University of Texas Houston Health Science Center, USA
J Am Coll Cardiol 44:1945-56. 2004Inflammation is a key feature of atherosclerosis and its clinical manifestations. The leukocyte count is a marker of inflammation that is widely available in clinical practice...
- White blood cell count and incidence of coronary heart disease and ischemic stroke and mortality from cardiovascular disease in African-American and White men and women: atherosclerosis risk in communities studyC D Lee
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, 55454-1015, USA
Am J Epidemiol 154:758-64. 2001..An elevated WBC count is directly associated with increased incidence of coronary heart disease and ischemic stroke and mortality from cardiovascular disease in African-American and White men and women...
- Obesity and the white blood cell count: changes with sustained weight lossJohn B Dixon
Australian Centre for Obesity Research and Education, Monash Medical School, The Alfred Hospital, Melbourne, Victoria, Australia
Obes Surg 16:251-7. 2006..The authors explored the relationship between the WBC and degree of obesity, basic anthropometry, and clinical and biochemical markers of the metabolic syndrome at baseline, and with weight loss following Lap-Band surgery...
- The associations of total and differential white blood cell counts with obesity, hypertension, dyslipidemia and glucose intolerance in a Korean populationDong Jun Kim
Department of Internal Medicine, Ilsanpaik Hostipal, Inje University College of Medicine, Goyang, Korea
J Korean Med Sci 23:193-8. 2008..Our data suggest that even within normal ranges, total WBC count and the differential WBC counts are associated with the presence of metabolic syndrome...
- White blood-cell count and the risk of impaired fasting glucose or Type II diabetes in middle-aged Japanese menN Nakanishi
Department of Social and Environmental Medicine, Course of Social Medicine, Osaka University Graduate School of Medicine F2, 2 2 Yamada oka, Suita Shi, Osaka 565 0871, Japan
Diabetologia 45:42-8. 2002..To investigate the association between white blood-cell (WBC) count and the development of diabetes, independent of cigarette smoking...
- Relationship between systemic markers of inflammation and serum beta-carotene levelsT P Erlinger
Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, 2024 E Monument St, Suite 2 600, Baltimore, MD 21205, USA
Arch Intern Med 161:1903-8. 2001..This pattern of findings raises the possibility that confounding by other factors might explain the association between serum beta-carotene level and disease risk...
- Sepsis severity predicts outcome in community-acquired pneumococcal pneumoniaB Schaaf
Medical Clinic III, University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
Eur Respir J 30:517-24. 2007..The prediction of survival in the intermediate-risk group might be more accurate with the sepsis score. Pre-hospital antibiotic treatment was associated with less severe disease...
- Clinical profile of homozygous JAK2 617V>F mutation in patients with polycythemia vera or essential thrombocythemiaAlessandro M Vannucchi
Department of Hematology, University of Florence, 50134 Florence, Italy
Blood 110:840-6. 2007..Irrespective of their clinical diagnosis, homozygous patients were older, displayed a higher leukocyte count and hematocrit value at diagnosis, and presented larger spleen volume...
- Early and late markers for the detection of early-onset neonatal sepsisL Bender
Department of Paediatrics, Aalborg Hospital, University of Aarhus, Aalborg, Denmark
Dan Med Bull 55:219-23. 2008..In this study we tested how a combination of early and late paraclinic markers could predict early onset neonatal sepsis (EONS)...
- Do peripheral blood counts have any prognostic value following trauma?T H Rainer
Accident and Emergency Medicine Academic Unit, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, People s Republic of China
Injury 30:179-85. 1999..The purpose of this study was to determine the early serial changes in peripheral leucocyte counts following injury...
- Use of plasma C-reactive protein, procalcitonin, neutrophils, macrophage migration inhibitory factor, soluble urokinase-type plasminogen activator receptor, and soluble triggering receptor expressed on myeloid cells-1 in combination to diagnose infectionsKristian Kofoed
Clinical Research Unit, Copenhagen University Hospital, Hvidovre, Kettegaard Alle 30, DK 2650 Hvidovre, Denmark
Crit Care 11:R38. 2007..Combinations of markers, as opposed to single ones, may improve diagnosis and thereby survival. We therefore compared the diagnostic characteristics of novel and routinely used biomarkers of sepsis alone and in combination...
- Preoperative C-reactive protein level and outcome following coronary surgeryMario Gaudino
Department of Cardiac Surgery, Catholic University, Rome, Italy
Eur J Cardiothorac Surg 22:521-6. 2002..It has been suggested that a preoperative level of C-reactive protein (CRP)>5mg/l is predictive of postoperative complications in cardiac surgery patients...
- Serum C3 is a stronger inflammatory marker of insulin resistance than C-reactive protein, leukocyte count, and erythrocyte sedimentation rate: comparison study in an elderly populationAntonio Muscari
Department of Internal Medicine, Cardioangiology, and Hepatology, University of Bologna, Bologna, Italy
Diabetes Care 30:2362-8. 2007..This study was performed to ascertain the relative relevance of some inflammatory markers in insulin resistance...
- Early markers of late-onset sepsis in premature neonates: clinical, hematological and cytokine profileBlanca E Gonzalez
Department of Medicine, Division of Neonatology, Department of Pediatrics, Albert Einstein Medical Center, Philadelphia, USA
J Perinat Med 31:60-8. 2003..Late-onset sepsis in the NICU is a major problem associated with high morbidity and mortality...
- Clinical utility of the band countP Joanne Cornbleet
Department of Pathology, Stanford University Medical Center, Stanford, California, USA
Clin Lab Med 22:101-36. 2002..In the near future, rapid analysis of inflammatory factors, adhesion molecules, cytokines, neutrophil surface antigens, or even bacterial DNA may be superior alternative tests for the early diagnosis of sepsis...
- The immunomodulatory actions of prostaglandin E2 on allergic airway responses in the ratJames G Martin
Meakins Christie Laboratories, Department of Medicine, McGill University, Montreal, Quebec, Canada
J Immunol 169:3963-9. 2002..We conclude that PGE(2) is a potent anti-inflammatory agent that may act by reducing allergen-induced Th2 cell activation and cysteinyl-leukotriene synthesis in the rat...
- Diagnostic and prognostic accuracy of clinical and laboratory parameters in community-acquired pneumoniaBeat Muller
Departments of Internal Medicine, University Hospital, Petersgraben 4, CH 4031, Basel, Switzerland
BMC Infect Dis 7:10. 2007..This study aims to evaluate the diagnostic and prognostic accuracy of clinical signs and symptoms and laboratory biomarkers for CAP...
- White blood cell count and the metabolic syndrome in older Chinese: the Guangzhou Biobank Cohort StudyXiang Qian Lao
Department of Community Medicine and School of Public Health, The University of Hong Kong, Pokfulam, Hong Kong
Atherosclerosis 201:418-24. 2008..To examine the association between white blood cell count (WBC) and metabolic syndrome (MS) in an older Chinese population...
- White blood cell count and risk for all-cause, cardiovascular, and cancer mortality in a cohort of KoreansSun Ha Jee
Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea
Am J Epidemiol 162:1062-9. 2005..lowest quintile: hazard ratio = 1.46, 95% confidence interval: 1.25, 1.72). These findings indicate that the white blood cell count is an independent risk factor for all-cause mortality and for ASCVD mortality...
- Preoperative neutrophil-lymphocyte ratio and outcome from coronary artery bypass graftingPatrick H Gibson
Department of Cardiology, University of Aberdeen and Aberdeen Royal Infirmary, Aberdeen, United Kingdom
Am Heart J 154:995-1002. 2007..We hypothesized that the N/L ratio would predict the outcome of patients undergoing surgical revascularization...
- Relationship between white blood cell count and incident hypertensionAnoop Shankar
Department of Ophthalmology, University of Wisconsin Medical School, 610 N Walnut Street, 405 WARF, Madison, WI 53726 2336, USA
Am J Hypertens 17:233-9. 2004..However, its relationship to hypertension, independent of smoking and other established cardiovascular risk factors, is not clear, especially among women...
- Acute stress enhances while chronic stress suppresses cell-mediated immunity in vivo: a potential role for leukocyte traffickingF S Dhabhar
Rockefeller University, New York, NY 10021, USA
Brain Behav Immun 11:286-306. 1997..These results suggest that stress-induced alterations in lymphocyte redeployment may play an important role in mediating the bi-directional effects of acute versus chronic stress on cell-mediated immunity in vivo...
- Smoking cessation and cardiovascular disease risk factors: results from the Third National Health and Nutrition Examination SurveyArvind Bakhru
University of Rochester Medical Center, School of Medicine, Rochester, New York, USA
PLoS Med 2:e160. 2005..It also remains unclear as to whether traditional risk factors can adequately explain the observed decline in cardiovascular risk following smoking cessation...
- Automated enumeration of immature granulocytesBernard Fernandes
Department of Laboratory Medicine, Mount Sinai Hospital and University of Toronto, Toronto, Canada
Am J Clin Pathol 128:454-63. 2007..The results also confirm that the flow cytometric IG count is superior to and can replace the manual morphology count as a reference method for IG counting...
- Relation of markers of inflammation (C-reactive protein, fibrinogen, von Willebrand factor, and leukocyte count) and statin therapy to long-term mortality in patients with angiographically proven coronary artery diseaseChristoph Bickel
Department of Medicine II, Johannes Gutenberg University Mainz, Germany
Am J Cardiol 89:901-8. 2002..001), fibrinogen (p = 0.006), von Willebrand factor (p = 0.006), and leukocyte count (p = 0...
- Inducible cardiac ischaemia is related to a decrease in the whole-blood Toll-like receptor 2 and 4 responseEllen H A M Elsenberg
Laboratory of Experimental Cardiology, University Medical Centre Utrecht, Utrecht, The Netherlands
Clin Sci (Lond) 122:527-33. 2012..These results point to a regulating role of TLRs in order to prevent excessive inflammatory events known to occur during acute ischaemia...
- Role of neutrophil to lymphocyte ratio as a prognostic indicator for epithelial ovarian cancerThaovalai Thavaramara
Department of Obstetrics and Gynecology, Bangkok Metropolitan Administration Medical College and Vajira Hospital, Bangkok, Thailand
J Med Assoc Thai 94:871-7. 2011..The present study further aimed to evaluate the impact of the change of preoperative/postoperative NLR on the survival...
- The open window of susceptibility to infection after acute exercise in healthy young male elite athletesM W Kakanis
Faculty of Health Sciences and Medicine, Bond University, Robina, Queensland, Australia
Exerc Immunol Rev 16:119-37. 2010..Suppression of total lymphocyte counts, NK cell counts and neutrophil phagocytic function following exercise may be important in the increased rate of URI in response to regular intense endurance training...
- Leukocyte count is an independent predictor for risk of acute myocardial infarction in middle-aged Japanese menHironori Imano
Osaka Medical Center for Health Science and Promotion, 1 3 2 Nakamichi, Higashinari ku, Osaka Shi, Osaka 537 0025, Japan
Atherosclerosis 195:147-52. 2007b>Leukocyte count is recognized as an inflammatory marker and a predictor of cardiovascular events. However, it is uncertain whether the contribution of leukocyte count to the risk of cardiovascular disease is independent of smoking.
- Procalcitonin predicts patients at low risk of death from community-acquired pneumonia across all CRB-65 classesS Kruger
Dept of Internal Medicine II, Ulm University Hospital, Ulm, Germany
Eur Respir J 31:349-55. 2008..prognostic accuracy as the CRB-65 score and a higher prognostic accuracy compared with C-reactive protein and leukocyte count. Procalcitonin levels can provide independent identification of patients at low risk of death within CRB-65 (..
- Eosinopenia: Is it a good marker of sepsis in comparison to procalcitonin and C-reactive protein levels for patients admitted to a critical care unit in an urban hospital?Hamid Shaaban
Infectious Diseases Division, St Michael s Medical Center, Newark, NJ 07102, USA
J Crit Care 25:570-5. 2010..The role of eosinopenia as a marker of sepsis has recently been evaluated. The aim of our study was to test the value of eosinopenia as a diagnostic marker of sepsis in comparison to procalcitonin and C-reactive protein levels...
- Bacteraemia prediction in emergency medical admissions: role of C reactive proteinD H Wyllie
Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
J Clin Pathol 58:352-6. 2005..To define the contribution made by C reactive protein (CRP) measurement to bacteraemia prediction in adults with medical emergencies in the UK...
- Plasma glucose levels and white blood cell count are related with ankle brachial index in type 2 diabetic subjectsAthanasia Papazafiropoulou
3rd Department of Internal Medicine and Center of Diabetes, General Hospital of Nikaia Ag Panteleimon, Piraeus, Greece
Hellenic J Cardiol 51:402-6. 2010..The aim of the present study was to determine whether there is an association between ABI and cardiovascular risk factors in T2DM subjects without apparent macrovascular disease...
- Eosinopenia as a diagnostic marker of bloodstream infection in hospitalised paediatric and adult patients: a case-control studyB A Wibrow
Royal Perth Hospital and Princess Margaret Hospital for Children, Perth, Western Australia, Australia
Anaesth Intensive Care 39:224-30. 2011..C-reactive protein concentrations and neutrophil counts were both better markers of bloodstream infection than eosinopenia in hospitalised paediatric and adult patients...
- TIDAL LAVAGE VS SHAM LAVAGE IN KNEE OSTEOARTHRITISJohn Bradley; Fiscal Year: 1999..specific characteristics, including baseline WOMAC score; radiographic severity of OA, synovial fluid leukocyte count and crystal content; and general health status, as measured by the Quality of Well Being (QWB) scale...
- Nursing Inquiry: Stress & Immune Response with BatteringSTEPHANIE WOODS; Fiscal Year: 2003..childhood maltreatment as a moderator of PTSD symptoms in battered women; 4) describe immune status via leukocyte count, lymphocyte subset counts (CD4 cell, CD8 cell, B-cell, and natural killer cell), CD4:CD8 ratio, number of ..
- Inflammation and Infection as Risk Factors in StrokeMitchell Elkind; Fiscal Year: 2006..Nationally recognized experts in stroke epidemiology and basic vascular biology will serve as mentors for these studies. ..
- Inflammatory and Infectious Burden and Risk of StrokeMitchell Elkind; Fiscal Year: 2008..The cross-sectional associations between inflammatory and infectious markers and quantitative MRI abnormalities will also be assessed. ..
- Levels of Inflammatory Markers in Treatment of StrokeMitchell Elkind; Fiscal Year: 2008..abstract_text> ..
- Noninvasive biomarkers of proteolytic activity in CFScott Sagel; Fiscal Year: 2007..In addition, he will actively participate and train in the Pediatric GCRC, and frequently interact with his sponsor, mentors, and collaborators. ..
- Hu1D10 in CLL: CLINICAL AND LABORATORY STUDIESJohn Byrd; Fiscal Year: 2006..abstract_text> ..
- Role of Cytokines in Two Hit Organ InjuryJean Nemzek; Fiscal Year: 2006..Successful completion of these aims could impact current two hit theories and use of immune therapy in septic patients exposed to additional inflammatory insults. ..
- Interventions for Tobacco Dependent AdolescentsDorothy Hatsukami; Fiscal Year: 2005....
- TREATMENT OF SMOKELESS TOBACCO USERSDorothy Hatsukami; Fiscal Year: 2008..PERFORMANCE SITE ========================================Section End=========================================== ..
- TOBACCO EXPOSURE REDUCTIONDorothy Hatsukami; Fiscal Year: 2008..The results of research from this TTURC will provide the scientific basis for urgent policy, public education, and regulatory efforts to reduce tobacco harm. ..
- Building a Latino admixture map & pilot study to find Type 2 Diabetes riskDavid Reich; Fiscal Year: 2007..The study will also enable larger admixture mapping studies with many thousands of patients with Type 2 Diabetes, which we would like to pursue both in U.S. Latino and in Latin American populations. [unreadable] [unreadable] [unreadable]..
- Associating genetic variation to resistance to severe malaria in East AfricaDavid Reich; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Mechanisms of Vascular Injury in the preterm lungSuhas Kallapur; Fiscal Year: 2006..The experimental design in this proposal incorporates challenging but, particularly in this environment achievable goals that will provide important knowledge in the pathogenesis of bronchopulmonary dysplasia. ..
- RISK FACTORS IN BRONCHOPULMONARY DYSPLASIAMari Palta; Fiscal Year: 2006....
- Pharmacogenetics of Asparaginase-Induced PancreatitisLewis Silverman; Fiscal Year: 2007..abstract_text> ..
- Neurotoxicity of Chronic Exposure to Air PollutionLilian Calderon Garciduenas; Fiscal Year: 2006..abstract_text> ..
- GENETIC, BIOLOGIC, & IMMUNOLOGIC DETERMINANTS OF ASTHMAMario Castro; Fiscal Year: 2006..abstract_text> ..
- Use of symbiotics to reduce urinary oxalate excretionJOHN LIESKE; Fiscal Year: 2007..If results are positive, treatment for calcium oxalate kidney stones could be revolutionized. ..
- Psychological stress, cortisol, and B lymphocyte decrementsBonnie McGregor; Fiscal Year: 2007..The present study will begin to elucidate the mechanism by which psychological stress impairs immune response to vaccines. [unreadable] [unreadable] [unreadable]..
- Asthma Clinical Research Network-Washington UniversityMario Castro; Fiscal Year: 2007..We propose that it is only through such a collaboration that important questions regarding current and novel therapies and management of asthma can be answered. ..
- Mechanisms of methyl dithiocarbamate immunotoxicityStephen B Pruett; Fiscal Year: 2010..It is also expected that the detailed study of three important mechanisms of action, which will be examined in each aim, can be generalized to other situations or toxicants that alter these parameters. ..
- Endotoxin-induced Uveitis RevisitedJames T Rosenbaum; Fiscal Year: 2010..Future studies can buil d on these observations to test anti-inflammtory molecules induced by endotoxin as these molecules are potentially useful in the treatment of uveitis and other inflammations. ..
- HIV-Hepatitis C Virus Interactions and PathogenesisRaymond T Chung; Fiscal Year: 2010..These studies will shed considerable light on HIV-HCV pathogenic interactions and offer a means of productively disrupting these interactions. ..
- Th2 effects on eicosanoid pathways: implications for altered innate responses inSally E Wenzel; Fiscal Year: 2010..These three aims should provide new insights into how relationships between innate and adaptive/allergic immune responses influence inflammatory/repair, and finally clinical outcomes in chronic and acute asthma. ..
- Towards a better understanding of work-aggravated asthmaCatherine Lemiere; Fiscal Year: 2009..The occurrence of asthma exacerbations will be recorded. The economic impact of WAA will be assessed in terms of work disability and use of health resources and compared with OA and asthma without OA not WAA. ..
- Cytokine-CRH Interactions in IFN-alfa-Induced DepressionCharles Raison; Fiscal Year: 2009..abstract_text> ..
- Air Pollution and Central Nervous System DiseaseLilian Calderon Garciduenas; Fiscal Year: 2008..The Award will give me the opportunity to build new skills in 4 areas: Molecular Biology, DNA Damage, Developmental / Neurodegenerative Neuropathology, and to gain experience in grantsmanship. [unreadable] [unreadable]..
- IMMUNOLOGY/MOLECULAR BIOLOGY TRAINING IN OPHTHALMOLOGYJames Rosenbaum; Fiscal Year: 2007..The quality of the institution, the talents of the specific faculty, the abilities of the applicant pool, and the proven success of the program areadditional strengths of this application. ..
- Ras Pathway Mutations in Human LeukemiaMignon Loh; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- CHEMOTACTIC FACTORS IN ANIMAL MODELS OF UVEITISJames Rosenbaum; Fiscal Year: 2008..We believe that these aims are novel, innovative, especially suited to the skills and achievements demonstrated by our laboratory, and highly relevant to clarifying the pathogenesis of anterior uveitis. ..
- Investigation of Nod2: Implications for UveitisHolly Rosenzweig; Fiscal Year: 2008..Together, these studies will provide valuable new information on how Nod2 is involved in autoimmunity and the pathogeneis of uveitis. ..
- Nephrolithiasis and Chronic Kidney DiseaseJOHN LIESKE; Fiscal Year: 2007..This will gain additional urgency if in fact we demonstrate that NL is a significant risk factor for CKD. [unreadable] [unreadable] [unreadable]..
- Linkage Studies of Quantitative Ocular TraitsBarbara Klein; Fiscal Year: 2006..Subsequent follow-up with fine mapping of areas of interest in the genome is planned. ..
- Eosinophil Granule Proteins and Their FunctionsGerald Gleich; Fiscal Year: 2006..Overall, these studies will expand our knowledge of the molecules composing the eosinophil granule and provide new tools to dissect eosinophil function in disease. ..
- Healing Touch and Immunity in Advanced Cervical CancerSusan Lutgendorf; Fiscal Year: 2002....
- SIMIAN AIDS: SOCIAL STRESS, ENDOCRINE & IMMUNE FUNCTIONJohn Capitanio; Fiscal Year: 2004..abstract_text> ..
- Arsenic Trioxide Down-Regulates STAT3 Activity in AMLMeir Wetzler; Fiscal Year: 2004..In addition, we will attempt to identify the mode by which ATO controls the activity of STAT3 and how this effect alters the gene profile patterns and induces apoptosis. ..
- Family Clustering of Incidence & Progression of CataractBarbara Klein; Fiscal Year: 2003..We currently have no funds to support the proposed analyses. We believe this project offers the possibility of examining important hypotheses in a large group of families in a population-based framework. ..
- NOVEL ANIMAL MODELS OF HCV-RELATED HEPATOCARCINOGENESISRaymond Chung; Fiscal Year: 2003..Together, these models will help provide insights into the factors responsible for this devastating complication of chronic HCV infection. ..
- RISK FACTORS FOR ATHEROGENESIS IN TYPE 1 DIABETESMari Palta; Fiscal Year: 2003..Such information is critical in directing further efforts toward primary prevention of atherosclerosis in individuals with Type 1 diabetes mellitus. ..
- IMPROVING THE TREATMENT AND CONTROL OF HYPERTENSIONKaren Margolis; Fiscal Year: 2003..abstract_text> ..
- EFFECTS OF MISSPECIFICATION IN LONGITUDINAL MODELSMari Palta; Fiscal Year: 2003....
- FUSION GENES IN LEUKEMIA--DETERMINING SIGNIFICANCEMignon Loh; Fiscal Year: 2003..abstract_text> ..
- PROGRESSION OF AORTIC ATHEROMA IN STROKE/TIA PATIENTSSouvik Sen; Fiscal Year: 2004..Designing of future placebo controlled prospective studies aimed at investigating measures that may be used to treat AA in stroke/TIA patients. ..
- CELLULAR IMMUNE RESPONSE IN CHRONIC HEPATITIS CDavid Nelson; Fiscal Year: 2003..These studies will provide insight into basic immunologic principles associated with the host's immune response to this viral infection, as well as provide the basis for new interventional strategies. ..
- POST TRANSCRIPTIONAL CONTROL OF THE HUMAN N MYC GENEWilliam Carroll; Fiscal Year: 2002....
- TRANSFORMING GROWTH FACTOR BETA IN OXIDANT LUNG INJURYMICHAEL O REILLY; Fiscal Year: 2002..These studies are significant because understanding how ROS injure and kill pulmonary epithelial cells is critically important for improving clinical therapies that rely on supplemental oxygen. ..
- PEDIATRIC ONCOLOGY GROUPYaddanapudi Ravindranath; Fiscal Year: 2002....
- Role of Nanobacteria in Human Calcifying DiseaseJOHN LIESKE; Fiscal Year: 2004..abstract_text> ..
- Healing Touch, Immunity, and Fatigue in Breast CancerSusan Lutgendorf; Fiscal Year: 2004....
- NOVEL INHIBITOR OF CRYSTAL ADHESION TO RENAL CELLSJOHN LIESKE; Fiscal Year: 2004..Achieving these specific aims will provide new knowledge about mechanisms that mediate stone formation, and provide a rational basis for design of novel strategies to treat and/or prevent this disease. ..
- Chemokines and microglia in Alzheimer's diseaseJoseph El Khoury; Fiscal Year: 2005....
- Airway Remodeling in Severe AsthmaMario Castro; Fiscal Year: 2005..The identification of the potential variables associated with remodeling and severe asthma will help identify individuals at risk who would benefit from specific targeted therapy. ..
- Mechanisms of Immunotoxcity of Chemical StressorsStephen Pruett; Fiscal Year: 2005....
- Inducible NOS as a Treatment Target in CLLJ Weinberg; Fiscal Year: 2005....
- Neuroimmune Modulation of Virus Immunity In AgingRaymond Stowe; Fiscal Year: 2002..These data will subsequently be used to support an R01 application to develop a mechanistic investigation on how neuroendocrine hormones modulate herpesvirus-specific immunity in the elderly. ..
- Anterior Uveal Dendritic CellsJames Rosenbaum; Fiscal Year: 2004..These studies will clarify the function of the immune system within the eye and may suggest novel therapeutic approaches in the treatment of uveitis. ..
- TGF-BETA AND MATRIX METALLOPROTEINASES IN AIRWAY REPAIRSally Wenzel; Fiscal Year: 2002..abstract_text> ..
- Oxalate-Induced Renal Scarring and Crystal RetentionJOHN LIESKE; Fiscal Year: 2003..Dr. Luis Juncos has extensive experience studying the regulation of renal blood flow in vivo, and will be critical in our efforts to develop the constant infusion model of hyperoxalemia and hyperoxaluria. ..
- Monocyte / Macrophage TLR4 Expression and Signaling: A Link between Obesity and CBrian McFarlin; Fiscal Year: 2008..The primary purpose of this investigation is to determine if obesity status alters TLR4 signaling and/or inflammatory cytokine production in blood monocyte and adipose tissue macrophage. [unreadable] [unreadable] [unreadable]..
- Defibrotide for the treatment of severe hepatic veno-cc*Paul Richardson; Fiscal Year: 2007..Abstract Not Provided ..
- BEHAVIORAL AND IMMUNOLOGICAL FACTORS IN CORONARY DISEASEWillem Kop; Fiscal Year: 2005....
- Treatment and Costs of Neonatal Jaundice in a Large HMOThomas Newman; Fiscal Year: 2007..The results of this study will help make neonatal jaundice guidelines and treatment decisions more evidence based. [unreadable] [unreadable] [unreadable]..
- Regulation of Pulmonary Host Defense by LeptinPeter Mancuso; Fiscal Year: 2010..They will also test the use of exogenous leptin as an adjunctive therapeutic agent in the treatment of pneumococcal pneumonia. ..
- Murine CMV Pneumonitis in Allogeneic BMTOliver Oakley; Fiscal Year: 2005..This research will also provide the opportunity for students to participate actively in the solution to an important clinical problem. ..
- Monocyte Biology and BiodefenseDOUGLAS DREVETS; Fiscal Year: 2005..These data will then catalyze development of rational therapies to improve host defenses against severe and overwhelming infection by category A and B intracellular bacterial pathogens. ..
- Mechanisms for Reduced Limb Perfusion with Human AgingDOUGLAS SEALS; Fiscal Year: 2002..The expected results should provide new insight into the effects of age and gender on basal limb perfusion in adult humans and the underlying mechanisms. ..
- Molecular and Cellular Analyses of Aquaporins in LungLANDON KING; Fiscal Year: 2005..These studies should provide insight into mechanisms regulating expression of AQP1 and AQP5, and establish a framework from which to better understand their role in the pathophysiology of the respiratory tract. ..
- Human Aging and B-adrenergic Modulation of ThermogenesisDOUGLAS SEALS; Fiscal Year: 2009..The proposed research also will provide novel insight into the integrative (whole-body to molecular/genetic) physiological mechanisms underlying these effects. ..
- Hormone Replacement Therapy, SERMs & Leg Blood Flow in Postmenopausal WomenDOUGLAS SEALS; Fiscal Year: 2007..The results should provide new insight into the effects of HRT and a SERM for augmenting LBF and LVC in estrogen deficient postmenopausal women and the underlying physiological mechanisms. ..
- Hopkins Bayview Confocal Imaging SystemLANDON KING; Fiscal Year: 2007..Collectively, these diseases represent a significant burden on the health care system and account for a large fraction of deaths in the United States every year. [unreadable] [unreadable] [unreadable]..
- MOLECULAR AND CELLULAR ANALYSIS OF AQUAPORIN 1 IN LUNGLANDON KING; Fiscal Year: 2002..These studies should enhance the understanding of the molecular mechanisms regulating lung water homeostasis. ..