reticulocyte count

Summary

Summary: The number of RETICULOCYTES per unit volume of BLOOD. The values are expressed as a percentage of the ERYTHROCYTE COUNT or in the form of an index ("corrected reticulocyte index"), which attempts to account for the number of circulating erythrocytes.

Top Publications

  1. ncbi Early prediction of response to intravenous iron supplementation by reticulocyte haemoglobin content and high-fluorescence reticulocyte count in haemodialysis patients
    Chiao Lin Chuang
    Faculty of Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan
    Nephrol Dial Transplant 18:370-7. 2003
  2. ncbi Reticulocyte count, mean reticulocyte volume, immature reticulocyte fraction, and mean sphered cell volume in elite athletes: reference values and comparison with the general population
    Giuseppe Banfi
    Istituto Galeazzi, Via Galeazzi 4, 20161 Milan, Italy
    Clin Chem Lab Med 44:616-22. 2006
  3. ncbi Suppression of erythropoiesis in malarial anemia is associated with hemozoin in vitro and in vivo
    Climent Casals-Pascual
    Nuffield Department of Clinical Laboratory Sciences and National Blood Service Oxford Centre, John Radcliffe Hospital, Oxford OX3 9BQ, United Kingdom
    Blood 108:2569-77. 2006
  4. ncbi Evaluation of the automated hematology analyzer Sysmex XT-2000iV ™ compared to the ADVIA ® 2120 for its use in dogs, cats, and horses. Part II: Accuracy of leukocyte differential and reticulocyte count, impact of anticoagulant and sample aging
    Natali Bauer
    Department of Veterinary Clinical Sciences, Clinical Pathology and Clinical Pathophysiology, Justus Liebig University Giessen, Frankfurterstr 129, 35392 Giessen, Germany
    J Vet Diagn Invest 24:74-89. 2012
  5. ncbi Immature reticulocytes as an early predictor of engraftment in autologous and allogeneic bone marrow transplantation
    J F A Noronha
    Department of Clinical Pathology and Bone Marrow Transplantation Unit, State University of Campinas UNICAMP, Sao Paulo, Brazil
    Clin Lab Haematol 25:47-54. 2003
  6. ncbi Automated reticulocyte counting: state of the art and clinical applications in the evaluation of erythropoiesis
    Elisa Piva
    Department of Laboratory Medicine, University Hospital of Padova, Padova, Italy
    Clin Chem Lab Med 48:1369-80. 2010
  7. ncbi High reticulocyte count is an independent risk factor for cerebrovascular disease in children with sickle cell anemia
    Célia Maria Silva
    Hemominas Foundation, Belo Horizonte, Brazil
    Pediatr Blood Cancer 56:116-21. 2011
  8. pmc Elevated reticulocyte count--a clue to the diagnosis of haemolytic-uraemic syndrome (HUS) associated with gemcitabine therapy for metastatic duodenal papillary carcinoma: a case report
    S Serke
    Department of Haematology Oncology, Charite, Campus Virchow Klinikum, , Berlin, Germany
    Br J Cancer 79:1519-21. 1999
  9. ncbi Developmental toxicity of artesunate in the rat: comparison to other artemisinins, comparison of embryotoxicity and kinetics by oral and intravenous routes, and relationship to maternal reticulocyte count
    Robert L Clark
    GlaxoSmithKline, King of Prussia, Pennsylvania 19406 0939, USA
    Birth Defects Res B Dev Reprod Toxicol 83:397-406. 2008
  10. ncbi Effects of artemisinins on reticulocyte count and relationship to possible embryotoxicity in confirmed and unconfirmed malarial patients
    Robert L Clark
    Artemis Pharmaceutical Research, 1758 Allentown Road, Lansdale, Pennsylvania, USA
    Birth Defects Res A Clin Mol Teratol 94:61-75. 2012

Detail Information

Publications231 found, 100 shown here

  1. ncbi Early prediction of response to intravenous iron supplementation by reticulocyte haemoglobin content and high-fluorescence reticulocyte count in haemodialysis patients
    Chiao Lin Chuang
    Faculty of Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan
    Nephrol Dial Transplant 18:370-7. 2003
    ..Therefore, the aim of this study was to appraise the diagnostic power of these two parameters in the early prediction of response to intravenous iron (IVFE) medications in HD patients receiving rHuEpo...
  2. ncbi Reticulocyte count, mean reticulocyte volume, immature reticulocyte fraction, and mean sphered cell volume in elite athletes: reference values and comparison with the general population
    Giuseppe Banfi
    Istituto Galeazzi, Via Galeazzi 4, 20161 Milan, Italy
    Clin Chem Lab Med 44:616-22. 2006
    ..Few studies have considered the application of these parameters in athletes and a lack of specific reference ranges means that their valid clinical use is difficult...
  3. ncbi Suppression of erythropoiesis in malarial anemia is associated with hemozoin in vitro and in vivo
    Climent Casals-Pascual
    Nuffield Department of Clinical Laboratory Sciences and National Blood Service Oxford Centre, John Radcliffe Hospital, Oxford OX3 9BQ, United Kingdom
    Blood 108:2569-77. 2006
    ..Taken together, these observations provide compelling evidence for inhibition of erythropoiesis by Hz...
  4. ncbi Evaluation of the automated hematology analyzer Sysmex XT-2000iV ™ compared to the ADVIA ® 2120 for its use in dogs, cats, and horses. Part II: Accuracy of leukocyte differential and reticulocyte count, impact of anticoagulant and sample aging
    Natali Bauer
    Department of Veterinary Clinical Sciences, Clinical Pathology and Clinical Pathophysiology, Justus Liebig University Giessen, Frankfurterstr 129, 35392 Giessen, Germany
    J Vet Diagn Invest 24:74-89. 2012
    ..The overall performance of the Sysmex XT-2000iV was excellent and compared favorably with that of the ADVIA 2120. A special strength was the excellent detection of feline eosinophils...
  5. ncbi Immature reticulocytes as an early predictor of engraftment in autologous and allogeneic bone marrow transplantation
    J F A Noronha
    Department of Clinical Pathology and Bone Marrow Transplantation Unit, State University of Campinas UNICAMP, Sao Paulo, Brazil
    Clin Lab Haematol 25:47-54. 2003
    ..We compared absolute reticulocyte count (RetAbs), mean fluorescence index (MFI) and mean reticulocyte volume/mean corpuscular volume (MRV/MCV) ratio ..
  6. ncbi Automated reticulocyte counting: state of the art and clinical applications in the evaluation of erythropoiesis
    Elisa Piva
    Department of Laboratory Medicine, University Hospital of Padova, Padova, Italy
    Clin Chem Lab Med 48:1369-80. 2010
    The reticulocyte count reflects the erythropoietic activity of the bone marrow and is thus useful in both the diagnosis of anemias and in monitoring bone marrow response to therapy...
  7. ncbi High reticulocyte count is an independent risk factor for cerebrovascular disease in children with sickle cell anemia
    Célia Maria Silva
    Hemominas Foundation, Belo Horizonte, Brazil
    Pediatr Blood Cancer 56:116-21. 2011
    ..Transcranial Doppler ultrasonography (TCD) is an important way of detecting risk of ischemic stroke in children with sickle cell anemia...
  8. pmc Elevated reticulocyte count--a clue to the diagnosis of haemolytic-uraemic syndrome (HUS) associated with gemcitabine therapy for metastatic duodenal papillary carcinoma: a case report
    S Serke
    Department of Haematology Oncology, Charite, Campus Virchow Klinikum, , Berlin, Germany
    Br J Cancer 79:1519-21. 1999
    ..Re-exposure to gemcitabine 6 months after the episode of HUS instituted for progressive carcinoma, thus far has not caused another episode of HUS...
  9. ncbi Developmental toxicity of artesunate in the rat: comparison to other artemisinins, comparison of embryotoxicity and kinetics by oral and intravenous routes, and relationship to maternal reticulocyte count
    Robert L Clark
    GlaxoSmithKline, King of Prussia, Pennsylvania 19406 0939, USA
    Birth Defects Res B Dev Reprod Toxicol 83:397-406. 2008
    ..The antimalarial, artesunate, is teratogenic and embryolethal in rats, with peak sensitivity on Days 10 and 11 postcoitum (pc)...
  10. ncbi Effects of artemisinins on reticulocyte count and relationship to possible embryotoxicity in confirmed and unconfirmed malarial patients
    Robert L Clark
    Artemis Pharmaceutical Research, 1758 Allentown Road, Lansdale, Pennsylvania, USA
    Birth Defects Res A Clin Mol Teratol 94:61-75. 2012
    Rat studies suggest that artemisinin-induced decreases in reticulocyte count are a marker for embryotoxicity (in one study, r = 0.82; p < 0.05)...
  11. ncbi Pharmacodynamic analysis of changes in reticulocyte subtype distribution in phlebotomy-induced stress erythropoiesis
    Nidal H Al-Huniti
    College of Pharmacy, The University of Iowa, Iowa City, IA 52242, USA
    J Pharmacokinet Pharmacodyn 32:359-76. 2005
    ..analysis between various new, proposed metrics involving the HR, MR and LR fractions and the total reticulocyte count, with the latter indicative of stress erythropoiesis at higher total counts, revealed a highly significant ..
  12. ncbi [Reticulocyte as indication of the erythroid hematopoiesis: reticulocyte fractions in peripheral blood and bone marrow]
    T Kageoka
    Department of Clinical Laboratory, Kurashiki Central Hospital, Kurashiki 710-8602
    Rinsho Byori 49:485-9. 2001
    ..In cases of death after bone marrow transplantation unlike in survivors, reticulocyte fractions decreased after engraftment...
  13. ncbi Erroneously elevated immature reticulocyte counts in leukemic patients determined using a Sysmex XE-2100 hematology analyzer
    Jungwon Huh
    Department of Laboratory Medicine, Ewha Womans University College of Medicine, Seoul, South Korea
    Ann Hematol 86:759-62. 2007
    ..The findings of the present study demonstrate that IRF results may be erroneously elevated in leukemia patients and indicate that hematologists should examine reticulocyte scattergrams and UPP values carefully...
  14. ncbi Pharmacokinetic and pharmacodynamic modeling of recombinant human erythropoietin after intravenous and subcutaneous administration in rats
    Sukyung Woo
    Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, 565 Hochstetter Hall, State University of New York at Buffalo, Buffalo, NY 14260, USA
    J Pharmacol Exp Ther 319:1297-306. 2006
    ..87 and SC(50) = 65.37 mIU/ml) and mean lifespans of major erythropoietic cell populations in rats...
  15. ncbi Assessment of hematologic progenitor engraftment by complete reticulocyte maturation parameters after autologous and allogeneic hematopoietic stem cell transplantation
    A Torres
    Department of Hematology and Bone Marrow Transplantation, Reina Sofia University Hospital, Avda Menedez Pidal s n, 14004 Cordoba, Spain
    Haematologica 86:24-9. 2001
    ....
  16. ncbi Interference of blood leucocytes in the measurements of immature red cells (reticulocytes) by two different (semi-) automated flow-cytometry technologies
    N Villamor
    Virchow Klinikum, Medizinische Fakultat der Humboldt Universitat zu Berlin, Germany
    Clin Lab Haematol 18:89-94. 1996
    ..This error is directly correlated with the leucocyte count. The basis for reticulocyte identification should be improved before automated estimation of reticulocyte maturation can be used in clinical practice...
  17. ncbi Relation between reticulocyte count and characteristics of erythrocyte 5'-nucleotidase in dogs, cats, cattle and humans
    Mohammad Alamgir Hossain
    Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    J Vet Med Sci 65:193-7. 2003
    ..lead, erythrocyte 5'-nucleotidase was measured in dogs, cats, cattle and humans, and its relationship to the reticulocyte count in these species was determined...
  18. ncbi Iron-deficient erythropoiesis in neonatal rats
    Suzanne H Dubuque
    Department of Pediatrics, Steele Memorial Children s Research Center, University of Arizona Health Sciences Center, Tucson, AZ 85724 5073, USA
    Biol Neonate 81:51-7. 2002
    ..The neonatal rat is an excellent model of iron-deficient erythropoiesis and will be useful in designing future mechanistic studies examining the interplay between iron and erythropoiesis in the anemic, iron-challenged premature neonate...
  19. ncbi Haematological analysis conducted at the departure of the Tour de France 2001
    N Robinson
    Laboratoire Suisse d Analyse du Dopage, Institut Universitaire de Medecine Legale, Rue du Bugnon 21, 1005 Lausanne, Switzerland
    Int J Sports Med 26:200-7. 2005
    ..analysers of the same manufacturer to avoid too many variations notably on the haematocrit level and the reticulocyte count. Furthermore, this study suggests that analyses performed on the site are good and could enable the ..
  20. ncbi Autologous blood transfusion in radical hysterectomy with and without erythropoietin therapy
    Monica Hyllner
    Departments of Anesthesiology and Intensive Care, Sahlgrenska University Hospital, Goteborg University, Goteborg, Sweden
    Obstet Gynecol 99:757-62. 2002
    ..To investigate whether preoperative treatment with erythropoietin facilitates the collection of a sufficient amount of autologous blood in a short period of time...
  21. pmc Perioperative erythropoietin administration in patients with gastrointestinal tract cancer: prospective randomized double-blind study
    Nicholas Kosmadakis
    First Department of Propaedeutic Surgery, Hippokration General Hospital, Athens Medical School, University of Athens, Greece
    Ann Surg 237:417-21. 2003
    ....
  22. ncbi Effects of exercise on the secondary blood markers commonly used to suspect erythropoietin doping
    Neil Robinson
    Laboratoire Suisse d Analyse du Dopage, Institut Universitaire de Medecine Legale, Lausanne, Switzerland
    Clin Lab 49:57-62. 2003
    ..as the haematocrit level increased significantly after effort, whereas the plasma EPO concentration and the reticulocyte count remained constant...
  23. ncbi Re-challenging patients who developed pure red cell aplasia with epoetin: can it be done?
    Iain C Macdougall
    Department of Renal Medicine, King s College Hospital, London, UK
    Nephrol Dial Transplant 19:2901-5. 2004
  24. ncbi Hemoglobin levels correlate with interleukin-6 levels in patients with advanced untreated epithelial ovarian cancer: role of inflammation in cancer-related anemia
    Antonio Maccio
    Department of Obstetrics and Gynecology, Sirai Hospital, Carbonia, Italy
    Blood 106:362-7. 2005
    ..This evidence suggests that anemia in epithelial ovarian cancer is common and its presence is related to stage of disease and markers of inflammation...
  25. ncbi The Advia 120 red blood cells and reticulocyte indices are useful in diagnosis of iron-deficiency anemia
    Sanna Kotisaari
    Department of Clinical Chemistry and Hematology, Kuopio University Hospital, Finland
    Eur J Haematol 68:150-6. 2002
    ..Nevertheless, the advanced RBC and reticulocyte indices may prove to be useful tools in the evaluation of iron status and diagnosis of iron-deficiency anemia...
  26. ncbi [Reticulocyte]
    Katsumi Higashi
    Clinical Laboratory, Faculty of Medicine, University of Tokyo
    Nihon Rinsho 62:558-60. 2004
  27. ncbi Regulation of iron absorption in Hfe mutant mice
    Richard S Ajioka
    Division of Hematology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City 84132, USA
    Blood 100:1465-9. 2002
    ..Our data indicate that Hfe mutant mice retain the ability to regulate iron absorption. Mouse hemachromatosis protein (Hfe) plays a minor role in down-regulation but does not influence the up-regulation of iron absorption...
  28. ncbi Erythropoiesis and serum sVCAM-1 levels in adults with sickle cell disease
    A J Duits
    Red Cross Bloodbank Curaçao, Curacao, Netherlands Antilles
    Ann Hematol 82:171-4. 2003
    ....
  29. ncbi Zidovudine-related anemia with reticulocytosis
    P R Koduri
    Department of Medicine, Cook County Hospital, Hektoen Building, Room 817, Chicago, IL 60612, USA
    Ann Hematol 82:184-5. 2003
    ..These features can be mistaken for hemolytic disease, as shown by our experience with three such patients...
  30. pmc Pharmacokinetic and pharmacodynamic profiles of extended dosing of epoetin alfa in anemic patients who have chronic kidney disease and are not on dialysis
    Tracy McGowan
    Ortho Biotech Clinical Affairs, LLC, 430 Route 22 East, Bridgewater, NJ 08807, USA
    Clin J Am Soc Nephrol 3:1006-14. 2008
    ....
  31. ncbi Effect of altitude on second-generation blood tests to detect erythropoietin abuse by athletes
    Michael J Ashenden
    Science and Industry against Blood doping, Gold Coast QLD 4217, Australia
    Haematologica 88:1053-62. 2003
    ..We investigated changes in blood parameters and model scores during and after exposure to terrestrial and simulated altitudes...
  32. ncbi Associations between serum transferrin receptor concentrations and erythropoietic activities according to body iron status
    Jong Weon Choi
    Department of Laboratory Medicine, College of Medicine, Inha University, Inchon, South Korea
    Ann Clin Lab Sci 33:279-84. 2003
    ..In summary, iron deficiency leads to increased production of immature reticulocytes. Erythropoietic activity is more closely associated with log ferritin values than with sTfR concentrations in iron-deficiency anemia...
  33. ncbi The effect of common hematologic abnormalities on the ability of blood models to detect erythropoietin abuse by athletes
    Robin Parisotto
    Department of Physiology, Australian Institute of Sport, PO Box 176, Belconnen ACT 2616, Australia
    Haematologica 88:931-40. 2003
    ..Because hematologic abnormalities can also result in unusual blood profiles, the aim of this study was to document the incidence and magnitude of such abnormalities in an elite athlete population...
  34. ncbi [Anemia and erythropoietin in critically ill patients]
    S Baginski
    Universitätsklinikum Charité der Humboldt Universität zu Berlin, Campus Virchow Klinikum, Medizinische Klinik m S Nephrologie und Internistische Intensivmedizin
    Zentralbl Chir 128:487-92. 2003
    ..Recombinant human EPO has been proven to be effective in ameliorating the anemia of critical illness in several pilot studies and is currently being tested in larger trials...
  35. ncbi Marked decreases of total and immature reticulocytes in myelodysplastic syndrome among patients with pancytopenia
    Osamu Kabutomori
    Central Laboratory for Clinical Investigation, Osaka University Hospital, Suita, Japan
    Acta Haematol 109:212-3. 2003
  36. ncbi Reticulocyte indices rapidly reflect an increase in iron availability for erythropoiesis
    Sanna Kotisaari
    Haematologica 88:1422-3. 2003
  37. ncbi Beta-globin mRNA increases rapidly during erythropoietin treatment
    A Hagberg
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala Academic Hospital, Uppsala, Sweden
    Scand J Clin Lab Invest 63:239-45. 2003
    ..The response pattern of a possible new marker, beta-globin mRNA, is compared with reticulocyte count, levels of haemoglobin, transferrin receptor and ferritin after r-HuEpo treatment...
  38. ncbi Recombinant human erythropoietin in preoperative autologous blood donation did not influence the haemoglobin recovery after surgery
    A Avall
    Department of Anesthesia and Intensive Care, East Hospital, Goteborg, Sweden
    Acta Anaesthesiol Scand 47:687-92. 2003
    ..The aim of the study was to determine endogenous erythropoietin production and haemoglobin recovery after preoperative autologous blood donation and surgery, with or without recombinant human erythropoietin treatment...
  39. ncbi Abnormal hematologic profiles in elite cross-country skiers: blood doping or?
    James Stray-Gundersen
    Clin J Sport Med 13:132-7. 2003
    ..The purpose of this study was to examine the prevalence of abnormal hematologic profiles in elite cross-country skiers, which may indicate a high probability of blood doping...
  40. ncbi Dexamethasone treatment improves morphological and hematological parameters in chronic experimental schistosomiasis
    Alexandre S Pyrrho
    Departamento de Analises Clinicas e Toxicologicas, Faculdade de Farmacia, Cidade Universitaria, CCS, UFRJ, 21949 900 Rio de Janeiro, RJ, Brazil
    Parasitol Res 92:478-83. 2004
    ..These data suggest that treatment with dexamethasone results in a mild course of murine schistosomiasis and point to this drug as a promising agent to complement S. mansoni specific treatment...
  41. ncbi [Erythropoietin administration to preterm infants: comparison between subcutaneous and intravenous route]
    V Rigourd
    Service de réanimation néonatale, Institut de Puériculture et de Périnatalogie, 26, boulevard Brune, 75014 Paris, France
    Arch Pediatr 11:319-26. 2004
    ..Our aim was to compare the effectiveness of a one-month treatment with recombinant human erythropoietine (rHuEpo) according to the administration route...
  42. ncbi The effect of vitamin E-bonded dialyzer membrane on red blood cell survival in hemodialyzed patients
    Tatsuya Nakatan
    Department of Artificial Kidney, Osaka City University Medical School, Japan
    Artif Organs 27:214-7. 2003
    ..Therefore this study aimed to elucidate the effect of vitamin E-bonded dialyzer membrane on RBC life span by measuring creatine content in RBC...
  43. ncbi Recombinant human erythropoietin in mildly anemic women before total hysterectomy
    V Dousias
    Department of Obstetrics and Gynecology, University Hospital of Ioannina, Ioannina, Greece
    Clin Exp Obstet Gynecol 30:235-8. 2003
    ..The purpose of this study was to investigate the efficacy of preoperative recombinant human erythropoietin (rHuEPO) treatment in a group of mildly anemic women...
  44. ncbi Trekrezan as a modulator of hemato- and immunopoieses
    O P Kolesnikova
    Favorskii Institute of Chemistry, Siberian Division, Russian Academy of Sciences, ul Favorskogo 1, Irkutsk, 664033 Russia
    Dokl Biol Sci 391:306-8. 2003
  45. ncbi Erythropoiesis activity, iron availability and reticulocyte hemoglobinization during treatment with hemodialysis and in subjects with uremia
    Marianne Schoorl
    Department of Clinical Chemistry, Hematology and Immunology, Alkmaar, The Netherlands
    Clin Lab 52:621-9. 2006
    ..Slightly increased values for the ZPP/heme ratio in combination with elevated reticulocyte count reflect increased activity of erythropoiesis...
  46. ncbi Analysis of red cell parameters on the Sysmex XE 2100 and ADVIA 120 in iron deficiency and in uraemic chronic disease
    O David
    Department of Clinical Pathology, Regina Margherita S Anna Hospital, Turin, Italy
    Scand J Clin Lab Invest 66:113-20. 2006
    ..The aim of this study was to evaluate the extent to which the red cell parameters, RBC-Y and RET-Y, provided by Sysmex XE 2100, correlate with HYPO and CHr...
  47. ncbi Cessation of intensive treatment with recombinant human erythropoietin is followed by secondary anemia
    M Piron
    Department of Medicine, Division of Hematology, and the Department of Clinical Biology, Division of Laboratory Hematology, , , Belgium
    Blood 97:442-8. 2001
    ..This may rather represent intrinsic erythroid marrow exhaustion, mostly at the level of erythroid progenitors but also at later stages of erythropoiesis...
  48. ncbi Association of serum transferrin receptor concentration with markers of inflammation in Zimbabwean children
    Ishmael Kasvosve
    Department of Chemical Pathology, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe
    Clin Chim Acta 371:130-6. 2006
    ....
  49. ncbi Predicting erythroid response to recombinant erythropoietin plus granulocyte colony-stimulating factor therapy following a single subcutaneous bolus in patients with myelodysplasia
    David Bowen
    Haematologica 91:709-10. 2006
    ..In this small study, the reticulocyte response at day 7 was highly predictive of subsequent response to a therapeutic trial of epoietin + G-CSF...
  50. ncbi Patients with pulmonary and cardiac disease show an elevated proportion of immature reticulocytes
    R G Kendall
    Department of Haematology, The Freeman Hospital, Newcastle-upon Tyne, UK
    Clin Lab Haematol 23:27-31. 2001
    ..Furthermore, serial monitoring of the IRF may prove valuable in observing the efficacy of therapy in these patients...
  51. ncbi [Recombinant Human Erythropoietin (r-HuEPO) therapy in a newborn with hereditary spherocytosis]
    M Schiff
    Service de néonatologie et de réanimation néonatale, Hopital Debrousse, 29, rue Soeur Bouvier, 69322 cedex 05, Lyon, France
    Arch Pediatr 10:333-6. 2003
    ..The newborn with hereditary spherocytosis can develop severe anemia, requiring red blood cell transfusions. Therapy with r-HuEPO has been proposed to avoid transfusions...
  52. ncbi Efficacy of recombinant human erythropoietin in critically ill patients admitted to a long-term acute care facility: a randomized, double-blind, placebo-controlled trial
    Michael Silver
    Kindred Health Care, Chicago, IL, USA
    Crit Care Med 34:2310-6. 2006
    ..Recent data have shown that red blood cell transfusions in critically ill patients can be decreased with recombinant human erythropoietin (rHuEPO) therapy during their intensive care unit stay...
  53. ncbi Perioperative intravenous iron preserves iron stores and may hasten the recovery from post-operative anaemia after knee replacement surgery
    J A García-Erce
    Department of Haematology, University Hospital, Miguel Servet, Zaragoza, Spain
    Transfus Med 16:335-41. 2006
    ..Further studies are needed to ascertain which patients may benefit of extended intravenous iron and/or erythropoietin administration...
  54. pmc Erythropoiesis and myocardial energy requirements contribute to the hypermetabolism of childhood sickle cell anemia
    Jacqueline M Hibbert
    Department of Biochemistry, Morehouse School of Medicine, Atlanta, GA, USA
    J Pediatr Gastroenterol Nutr 43:680-7. 2006
    ..We hypothesized that an elevated hemoglobin synthesis rate (SynHb) and myocardial oxygen consumption (MVO2) contribute to the excess protein and energy metabolism reported in children with sickle cell anemia...
  55. ncbi The effect of subcutaneous recombinant human erythropoietin (r-Hu EPO) in CAPD patients with renal anaemia
    L Janicka
    Klinika Nefrologii Akademii Medycznej, Lublinie
    Ann Univ Mariae Curie Sklodowska Med 48:67-77. 1994
    ..We therefore present our result on the efficacy and safety of low dose r-Hu EPO given subcutaneously in th treatment of anemia in CAPD patients...
  56. ncbi Treatment of profound anemia with erythropoietin and steroids in a patient with X-linked chronic granulomatous disease associated with MacLeod erythrocyte phenotype
    Achille Aouba
    Am J Hematol 82:773-4. 2007
  57. ncbi Serum transferrin receptor in children: usefulness for determinating the nature of anemia in infection
    M Angeles Vázquez López
    Departments of Pediatrics, Hospital Torrecardenas, Almeria, Spain
    J Pediatr Hematol Oncol 28:809-15. 2006
    ....
  58. ncbi Recombinant human erythropoietin use in hemolytic anemia due to prosthetic heart valves: a promising treatment
    S Hirawat
    Don Monti Division of Medical Oncology, Department of Medicine, North Shore University Hospital-New York University School of Medicine, Manhasset, New York 11030, USA
    Am J Hematol 66:224-6. 2001
    ..Two patients are reported with hemolytic anemia due to red blood cell fragmentation in association with prosthetic heart vales. They were treated with erythropoietin which eliminated the need for packed red blood cell transfusion...
  59. ncbi Live high-train low for 24 days increases hemoglobin mass and red cell volume in elite endurance athletes
    Jon Peter Wehrlin
    Swiss Federal Institute of Sports, Section for Elite Sport, 2532 Magglingen, Switzerland
    J Appl Physiol (1985) 100:1938-45. 2006
    ..1,080+/-98 s; P<0.01) from pre- to postaltitude. Living at 2,500 m and training at lower altitudes for 24 days increases Hbmass and RCV. These changes may contribute to enhance performance of elite endurance athletes...
  60. ncbi The safety and efficacy of ferumoxytol therapy in anemic chronic kidney disease patients
    Bruce S Spinowitz
    Division of Nephrology and Hypertension, The New York Hospital Medical Center of Queens, Flushing, New York 11355, USA
    Kidney Int 68:1801-7. 2005
    ..This phase II clinical trial studied ferumoxytol, a semi-synthetic carbohydrate-coated iron oxide administered by rapid intravenous injection to anemic chronic kidney disease patients (predialysis or undergoing peritoneal dialysis)...
  61. ncbi Antibody-induced anemia in fetal sheep: model for hemolytic disease of the fetus and newborn
    R B Wolf
    Department of Reproductive Medicine, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0802, USA
    J Soc Gynecol Investig 8:224-32. 2001
    ..Furthermore, there appears to be a threshold degree of anemia required to elicit responses as the fetal EPO, PO(2), and lactate appeared unresponsive until hematocrit fell below 25%...
  62. ncbi Austrian Moderate Altitude Study (AMAS 2000): erythropoietic activity and Hb-O(2) affinity during a 3-week hiking holiday at moderate altitude in persons with metabolic syndrome
    Wolfgang Schobersberger
    University for Health Sciences, Medical Informatics and Technology Tyrol, Institute for Leisure, Travel and Alpine Medicine, Tyrol, Austria
    High Alt Med Biol 6:167-77. 2005
    ..b>Reticulocyte count and erythropoietin (EPO) were increased at T2 and increased further until T5...
  63. ncbi L-arginine administration reverses anemia associated with renal disease
    Takahisa Tarumoto
    Division of Hematology, Department of Medicine, Jichi Medical School, Shimotsuke, Japan
    Int J Hematol 86:126-9. 2007
    ..3 g/day of L-arginine significantly improves Epo production and reverses anemia without adverse effects in elderly patients who have anemia associated with renal disease and are in the predialysis state of chronic renal failure...
  64. ncbi Characterization of the iron transporter DMT1 (NRAMP2/DCT1) in red blood cells of normal and anemic mk/mk mice
    F Canonne-Hergaux
    Department of Biochemistry, McGill University, Montreal, QC, Canada
    Blood 98:3823-30. 2001
    ..Together, these results provide further evidence that DMT1 plays a central role in iron acquisition via the transferrin cycle in erythroid cells...
  65. ncbi Anemia of chronic disease is the more frequent type of anemia seen in patients with chronic idiopathic neutropenia of adults
    H A Papadaki
    Department of Hematology of the University of Crete School of Medicine, University Hospital of Heraklion, Greece
    Ann Hematol 80:195-200. 2001
    ..These findings further support our previously reported suggestion for the possible existence, in NI-CINA patients, of an unrecognized low-grade chronic inflammatory process that may be involved in the pathogenesis of the disorder...
  66. ncbi Hemoglobin mass and peak oxygen uptake in untrained and trained female altitude residents
    D Boning
    Institute of Sports Medicine Charité University Medicine Berlin, Berlin, Germany
    Int J Sports Med 25:561-8. 2004
    ....
  67. ncbi Reticulocyte evaluation in alpha(+)-thalassemia
    F Krügner
    Department of Clinical Pathology, School of Medical Sciences, State University of Campinas UNICAMP, Campinas, State of Sao Paulo, Brazil
    Am J Hematol 81:68-70. 2006
    ..0082 and 0.0436, respectively). The results found here are compatible with a compensated erythropoiesis and do not confirm the hypothesis mentioned above...
  68. ncbi Effects of erythropoietin on erythrocyte deformability in non-transfused preterm infants
    Martina Klipp
    Division of Neonatology, Department of Paediatrics, University of Heidelberg, Germany
    Acta Paediatr 96:253-6. 2007
    ..This prospective, randomised and controlled study was designed to find out whether rhEPO treatment improves erythrocyte deformability in preterm infants...
  69. ncbi [Clinical and laboratory prognostic parameters for leukemic types of chronic lymphoproliferative diseases]
    Ika Kardum-Skelin
    Klinicka bolnica Merkur, Zagreb, Hrvatska
    Acta Med Croatica 62:351-64. 2008
    ..The aim of the study was to identify the clinical and laboratory (hematologic, biochemical and morphological) prognostic parameters of chronic leukemic lymphoproliferative diseases (CLLPD)...
  70. ncbi An early (sixth-hour) serum bilirubin measurement is useful in predicting the development of significant hyperbilirubinemia and severe ABO hemolytic disease in a selective high-risk population of newborns with ABO incompatibility
    S Umit Sarici
    Division of Neonatology, Department of Pediatrics, Hacettepe University Faculty of Medicine Ihsan Doğramaci Children s Hospital, Ankara, Turkey
    Pediatrics 109:e53. 2002
    ....
  71. ncbi Interaction of stem cell factor and its receptor c-kit mediates lodgment and acute expansion of hematopoietic cells in the murine spleen
    V C Broudy
    Department of Medicine University of Washington, Seattle 98195, USA
    Blood 88:75-81. 1996
    ..The mice were killed on day 3 and the hematocrit (Hct), reticulocyte count, and numbers of erythroid and myeloid hematopoietic progenitor cells (colony-forming unit-erythroid [CFU-E], ..
  72. ncbi Erythropoietin therapy in children with bronchiolitis and anemia
    Brian R Jacobs
    Division of Critical Care Medicine, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Pediatr Crit Care Med 4:44-8. 2003
    ..with bronchiolitis and anemia would have a circulating erythropoietin deficiency and that treatment with exogenous erythropoietin would increase reticulocyte count and hematocrit and reduce red blood cell transfusion requirements.
  73. ncbi Influence of diet on the hematology and serum biochemistry of zinc-intoxicated mallards
    J M Levengood
    Center for Wildlife Ecology, Illinois Natural History Survey, Champaign 61820, USA
    J Wildl Dis 36:111-23. 2000
    ..Zn-dosed ducks had a lower mean erythrocyte packed cell volume (PCV), higher mean reticulocyte count, and a greater number of individuals with immature and/or abnormal erythrocytes, than did control mallards...
  74. ncbi [Evaluation of the efficacy of intravenous iron III-hydroxide saccharate for treating adult patients with iron deficiency anemia]
    Rodolfo Delfini Cançado
    Departamento de Clinica Medica, Faculdade de Ciencias Medicas, Santa Casa de Sao Paulo, Sao Paulo, SP
    Rev Assoc Med Bras 51:323-8. 2005
    ..To evaluate the efficacy of intravenous iron III-hydroxide saccharate for treating adult patients with iron deficiency anemia lacking satisfactory response to oral iron therapy...
  75. ncbi [Possible complications of erythropoietin therapy in patients with chronic renal failure]
    Steva Pljesa
    Nefrolosko odeljenje internisticke sluzbe, Medicinski fakultet Beograd, Klinicko Bolnicki Centar Zemun
    Med Pregl 57:254-7. 2004
    ..There have been many publications in the past 20 years about positive effects of human recombinant erythropoietin, which is used in treatment of anemia, especially in patients on dialysis...
  76. ncbi The association of anti-r-HuEpo-associated pure red cell aplasia with HLA-DRB1*09-DQB1*0309
    Kearkiat Praditpornsilpa
    Division of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn University Hospital, Bangkok, Thailand
    Nephrol Dial Transplant 24:1545-9. 2009
    ..This adverse immunological effect of r-HuEpo causes sudden loss of r-HuEpo efficacy, low circulating reticulocyte count and bone marrow biopsy shows an absence of erythroid precursor cells with normal cell population of non-..
  77. ncbi Megaloblastic anaemia: prevalence and causative factors
    Uma Khanduri
    Department of Haematology, St Stephen s Hospital, Tis Hazari, Delhi, India
    Natl Med J India 20:172-5. 2007
    ..Megaloblastic anaemia is not uncommon in India, but data are insufficient regarding its prevalence, and causative and precipitating factors. We did a prospective study to document such data for patients of megaloblastic anaemia...
  78. ncbi Pure red cell aplasia and anti-erythropoietin antibodies in patients treated with epoetin
    Nicole Casadevall
    Haematology Laboratory, Hopital Hotel Dieu, Paris, France
    Nephrol Dial Transplant 18:viii37-41. 2003
    ..with an absolute resistance to epoetin therapy and then rapidly develop severe anaemia with a very low reticulocyte count (<10 000/mm(3))...
  79. ncbi Reference values and hematologic changes from birth to 5 years in patients with sickle cell disease. Cooperative Study of Sickle Cell Disease
    A K Brown
    Department of Pediatrics, State University of New York Health Science Center at Brooklyn
    Arch Pediatr Adolesc Med 148:796-804. 1994
    ..To examine hematologic changes from birth to 5 years of age and establish hematologic reference values for infants and children with sickle cell disease...
  80. ncbi Glucose-6-phosphate dehydrogenase deficiency in neonates
    R Iranpour
    Department of Pediatrics, Al Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
    Indian J Pediatr 70:855-7. 2003
    ..Our aim was to study the prevalence of G6PD deficiency in relation to neonatal jaundice...
  81. ncbi Effect of intravenous iron supplementation on erythropoiesis in erythropoietin-treated premature infants
    A Pollak
    Department of Neonatology, University Children s Hospital, Vienna, Austria
    Pediatrics 107:78-85. 2001
    ..To test the efficacy and safety of combining intravenous iron in amounts approximating the in utero iron accretion rate and the postnatal iron loss with erythropoietin (EPO) in very low birth weight (VLBW) infants...
  82. ncbi Severe autoimmune cytopenias in treatment-naive hepatitis C virus infection: clinical description of 35 cases
    Manuel Ramos-Casals
    Department of Autoimmune Diseases, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic, School of Medicine, University of Barcelona, Spain
    Medicine (Baltimore) 82:87-96. 2003
    ..6 mg/dL in the serum unconjugated bilirubin level, a reticulocyte count >5%, and a positive direct Coombs test. Severe neutropenia was defined as a neutrophil count <0...
  83. ncbi Severe anemia from parvovirus b19 infection in pediatric renal transplant recipients: two case reports
    V Pinto
    Exequiel Gonzalez Cortes Hospital, Metropolitan Southern Health Service, Pediatric Department, University of Chile School of Medicine, Santiago, Chile
    Transplant Proc 40:3261-4. 2008
    ..Herein we have reported our experience with two pediatric renal transplant recipients who had severe pure red cell aplasia in the early period after surgery, accompanying PVB19 infection...
  84. ncbi Urinary tract infection in term neonates with prolonged jaundice
    Nader Pashapour
    Department of Pediatrics, Imam Hospital, Urmia University of Medical Sciences, Urmia, Iran
    Urol J 4:91-4; discussion 94. 2007
    ..The aim of this study was to evaluate the frequency of urinary tract infection (UTI) in neonates with prolonged jaundice...
  85. ncbi Thrombotic thrombocytopenic purpura induced by metronidazole vaginal gel
    Anastasia Rivkin
    Arnold and Marie Schwartz College of Pharmacy and Health Sciences, Brooklyn, New York 11201, USA
    Pharmacotherapy 27:1058-61. 2007
    ..Patients with TTP often have an increased reticulocyte count, elevated serum lactate dehydrogenase level, and decreased serum haptoglobin level...
  86. ncbi Impact of daily consumption of iron fortified ready-to-eat cereal and pumpkin seed kernels (Cucurbita pepo) on serum iron in adult women
    Mohammad Reza Naghii
    Department of Nutrition, Faculty of Health, Baqiyatallah a s University of Medical Sciences, Tehran, Iran
    Biofactors 30:19-26. 2007
    ..collected on the day 20 of menstrual cycles before and after consumption and indices of iron status such as reticulocyte count, hemoglobin (Hb), hematocrit (Ht), serum ferritin, iron, total iron-binding capacity (TIBC), transferrin and ..
  87. ncbi Jaundice with hepatic dysfunction in P. falciparum malaria
    Ali Hassan Abro
    Infectious Disease Unit, Rashid Hospital, Dubai, UAE
    J Coll Physicians Surg Pak 19:363-6. 2009
    ..To evaluate the frequency and severity of jaundice with hepatic dysfunction in Plasmodium (P.) falciparum malaria in adult patients admitted in the hospital...
  88. ncbi An automated optoelectronic reticulocyte counter
    K Kojima
    Department of Clinical and Laboratory Medicine, Osaka City, University Medical School, Japan
    Am J Clin Pathol 92:57-61. 1989
    ..007 +/- 0.0055 (0.70 +/- 0.55%) for the reticulocytes, (4.63 +/- 1.09) X 10(9)/L for the reticulocyte count, 2.3 +/- 1.9% for highly fluorescent cells, 18.7 +/- 5.1% for moderately fluorescent cells, and 78.8 +/- 6...
  89. pmc Characterization of the myelotoxicity of chloramphenicol succinate in the B6C3F1 mouse
    John A Turton
    Centre for Toxicology, Department of Pharmacology, The School of Pharmacy, University of London, London, UK
    Int J Exp Pathol 87:101-12. 2006
    ..The blood HFR reticulocyte count was a precise indicator of CAPS-induced depressive effects and subsequent recovery...
  90. ncbi Glucose-6-phosphate dehydrogenase deficiency in neonatal indirect hyperbilirubinemia
    Enver Atay
    Zeynep Kamil Maternity and Children s Research Hospital, Istanbul, Turkey
    J Trop Pediatr 52:56-8. 2006
    ..newborn, complete blood count, peripheral blood smear, serum total and direct bilirubin, direct coombs test, reticulocyte count, serum-free T4 and TSH, urine analysis, urinary reducing substance and erythrocyte G6PD level...
  91. ncbi Evaluation of intravascular hemolysis with erythrocyte creatine in patients with cardiac valve prostheses
    Toshika Okumiya
    Department of Laboratory Medicine, Faculty of Medicine, Kochi Medical School, Nankoku, Japan
    Chest 125:2115-20. 2004
    ..Erythrocyte creatine, a marker of erythrocyte age that increases with shortening erythrocyte survival, was evaluated with other hemolytic markers and hemodynamic parameters...
  92. ncbi Hydrops fetalis and neonatal death from human parvovirus B19: an unusual complication
    T Marton
    Department of Histopathology Birmingham Women s Hospital, Edgbaston, Birmingham, UK
    Prenat Diagn 25:543-5. 2005
    ..This was confirmed on fetal blood sampling, but recovery was suggested with a reticulocyte count of 16.8%. The fetal karyotype was normal, 46,XY. Fetal IgM was positive for Parvovirus...
  93. ncbi Blood conservation in the critically ill
    Jennifer Thomas
    Intensive Care Unit, St Agnes Hospital Pharmacy, Baltimore, MD 21229, USA
    Am J Health Syst Pharm 64:S11-8. 2007
    ....
  94. ncbi Erythropoiesis in women during 11 days at 4,300 m is not affected by menstrual cycle phase
    J T Reeves
    University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Appl Physiol (1985) 91:2579-86. 2001
    ..phases, and, where comparison within women was available, cycle phase did not alter erythropoietin (n = 5), reticulocyte count (n = 10), and red cell volume (n = 9)...
  95. ncbi [Determination by flow cytometry of reference values of erythrocyte parameters in aged subjects]
    H Blain
    Centre de Gérontologie clinique, CHU de Montpellier
    Presse Med 30:779-84. 2001
    ..We compared normal values of hematological parameters in healthy adults and healthy persons aged 65 years and over using flow cytometry...
  96. ncbi Spectrum and outcome analysis of marked neonatal hyperbilirubinemia with blood group incompatibility
    Yi Hao Weng
    Division of Neonatology, Department of Pediatrics, Chang Gung Children s Hospital, Taipei, Chang Gung University College of Medicine, Taoyuan, Taiwan
    Chang Gung Med J 32:400-8. 2009
    ..In the current study, we investigate the spectrum and outcome of marked neonatal hyperbilirubinemia with blood group incompatibility...
  97. ncbi Transgenic rescue of hemolytic anemia due to red blood cell pyruvate kinase deficiency
    Hitoshi Kanno
    Department of Transfusion Medicine and Cell Processing, Tokyo Women s Medical University, Tokyo, Japan
    Haematologica 92:731-7. 2007
    ..To test whether the targeted overexpression of the normal R-PK gene in erythroid cells could reduce hemolysis in R-PK mutant mice, we performed a genetic rescue study using human R-PK transgenic mice...
  98. ncbi Pure red cell aplasia accompanied by autoimmune hemolytic anemia in a patient with type A viral hepatitis
    Hiromi Koiso
    Medicine and Clinical Science, Gunma University Graduate School of Medicine, Japan
    Rinsho Ketsueki 50:424-9. 2009
    ..and a positive direct Coombs test were detected and these findings indicated AIHA complication; however, the reticulocyte count decreased and bone marrow showed marked erythroid hypoplasia so the co-existence of PRCA was diagnosed...
  99. ncbi [Pathophysiology, diagnosis and treatment of anemia]
    Keiya Ozawa
    Division of Hematology, Department of Medicine, Jichi Medical University
    Nihon Rinsho 66:423-8. 2008
    ..Iron parameters (serum iron, serum ferritin, etc.), reticulocyte count, bone marrow examination, Coombs test, serum vitamin B12 level, and Ham test are also useful in the ..
  100. ncbi Plasma exchange for treatment of thrombotic thrombocytopenic purpura in critically ill patients
    P Knobl
    Department of Medicine I, University of Vienna, Austria
    Intensive Care Med 23:44-50. 1997
    ..Description of diagnostic procedures, treatment modalities and intensive care management of patients with thrombotic thrombocytopenic purpura (TTP)...
  101. ncbi Brief communication: Successful treatment of pure red-cell aplasia with an anti-interleukin-2 receptor antibody (daclizumab)
    Elaine M Sloand
    Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Ann Intern Med 144:181-5. 2006
    ..Most patients respond to some form of immunosuppressive treatment, but few prospective clinical trials have been performed...

Research Grants17

  1. Inducing Fetal Hemoglobin to Treat Sickle Cell Disease
    Christian Hassig; Fiscal Year: 2004
    ..5-$2 billion annually in health care costs in the United States alone. It is anticipated that this work will generate a desperately needed long-term therapy for SCD. ..
  2. Malaria and the safety of iron interventions: absorption and NTBI
    Gary M Brittenham; Fiscal Year: 2012
    ..inflammatory cytokines, erythrocyte zinc protoporphyrin, and the complete blood count with absolute reticulocyte count and reticulocyte hemoglobin content (CHr)...
  3. Acute vs. delayed iron therapy: effect on iron status, anemia and cognition
    Chandy C John; Fiscal Year: 2013
    ..Hemoglobin, iron status (ZnPP, ferritin, TfR), erythropoiesis (erythropoietin, reticulocyte count) and inflammation (hepcidin, ferritin, alphal-acid glycoprotein, cytokines) will then be measured at ..
  4. Enhancing Use of Hydroxyurea In Sickle Cell Disease Using Patient Navigators
    Wally R Smith; Fiscal Year: 2013
    ..or maximum dose;ED and hospital visits;mean corpuscular volume;total hemoglobin;white blood cell count;reticulocyte count;and quality of life...
  5. A novel mechanism of coagulation in sickle cell disease
    JULIA BRITTAIN; Fiscal Year: 2012
    ..We also found a strong correlation between stress reticulocyte count, the number of the sRetic/monocyte aggregates and tissue factor (TF) activity on plasma microparticles and ..
  6. ORAL L GLUTAMINE THERAPY FOR SICKLE CELL ANEMIA
    Yutaka Niihara; Fiscal Year: 2001
    ..or chronic pain, 3) sickle cell anemia patients' hematological parameters including hemoglobin, hematocrit, reticulocyte count,and hexokinase level, and 4) adverse effects attributable to L-glutamine...
  7. EVENT RECORDINGS OF HIGH RISK INFANTS ON APNEA MONITORS
    DEBRA WEESE MAYER; Fiscal Year: 1991
    ..Baseline studies will include hematocrit, reticulocyte count, echocardiogram, cranial ultrasound, hair analysis for illicit drugs, growth parameters, and ..
  8. Epo as a Rescue Agent for Perinatal Hypoxia-Ischemia
    Sandra Juul; Fiscal Year: 2004
    ....
  9. METABOLIC CONSEQUENCES OF ANTIRETROVIRAL THERAPY
    DAVID WEIGLE; Fiscal Year: 2003
    ..Future trials of these medications, along with a great deal more basic research, are clearly justified by the increasing and sustained use of HAART to deal with the worldwide epidemic of HIV infection. ..
  10. TRAUMA-RELATED ERYTHROPOIETIC SUPPRESSION
    David Livingston; Fiscal Year: 2003
    ..Understanding the mechanisms behind post-trauma anemia will allow therapeutic interventions improving endogenous erythropoiesis to be targeted. ..
  11. ETIOLOGY OF STROKE IN CHILDREN WITH SICKLE CELL DISEASE
    Sherri Zimmerman; Fiscal Year: 2004
    ..Based on this fact-finding study, I will design a hypothesis-driven therapeutic clinical trial for children at highest risk of developing stroke. ..
  12. Modulators of Nitric Oxide Synthase Activity in Sickle Cell Disease
    Mary E Fabry; Fiscal Year: 2010
    ..These observations may be applicable to patient interventions. ..
  13. Chicago Sickle Cell Clinical Network
    Joseph DeSimone; Fiscal Year: 2008
    ..To determine if there is a genetic basis for treatment variation, we will evaluate patients for genotypic variability using a number of polymorphic genes, such as mu receptor, MDR1 protein, and cytochrome 2D6. ..
  14. Genetic Dissection of Sickle Cell Anemia Phenotypes
    Paola Sebastiani; Fiscal Year: 2006
    ..abstract_text> ..
  15. DNA Methylation, Chromatin, and Globin Gene Silencing
    Joseph DeSimone; Fiscal Year: 2006
    ..These studies will define the mechanisms of gamma-globin gene silencing, and will aid in the development of new procedures to augment HbF production in patients with sickle cell disease. ..
  16. Nonhematopoietic Developmental Functions of EPO
    Sandra Juul; Fiscal Year: 2004
    ..We feel these experiments will provide important specific insights into the regulation of neonatal intestinal growth and injury. ..
  17. STUDIES OF REGIONAL FAT DISTRIBUTION AND ENERGY BALANCE
    DAVID WEIGLE; Fiscal Year: 2005
    ..The applicant has successfully trained several young physician investigators in patient-oriented and basic research, and a plan to continue doing so is presented. ..