blood cell count

Summary

Summary: The number of LEUKOCYTES and ERYTHROCYTES per unit volume in a sample of venous BLOOD. A complete blood count (CBC) also includes measurement of the HEMOGLOBIN; HEMATOCRIT; and ERYTHROCYTE INDICES.

Top Publications

  1. ncbi Haemotoxicity of thiamphenicol in the BALB/c mouse and Wistar Hanover rat
    J A Turton
    Centre for Toxicology, Department of Pharmacology, The School of Pharmacy, University of London, 29 39 Brunswick Square, UK
    Food Chem Toxicol 40:1849-61. 2002
  2. ncbi Red cell distribution width in patients with prehypertension and hypertension
    Asli Tanindi
    Department of Cardiology, Cankiri State Hospital, Aksu mahallesi, Ogretmenler, Sokak, Cankiri, Turkey
    Blood Press 21:177-81. 2012
  3. pmc Eosinophil count and neutrophil-lymphocyte count ratio as prognostic markers in patients with bacteremia: a retrospective cohort study
    Roser Terradas
    Department of Epidemiology and Health Services Evaluation, Hospital del Mar, Barcelona, Espana
    PLoS ONE 7:e42860. 2012
  4. ncbi The value of a complete blood count in predicting cancer of the colon
    Derrick W Spell
    Department of Internal Medicine, Division of Hematology Oncology, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0565, USA
    Cancer Detect Prev 28:37-42. 2004
  5. ncbi Acute inflammatory responses in the airways and peripheral blood after short-term exposure to diesel exhaust in healthy human volunteers
    S Salvi
    University Medicine Department, Southampton General Hospital, Southampton, and Cardiovascular Research, The Rayne Institute, St Thomas Hospital, London, United Kingdom
    Am J Respir Crit Care Med 159:702-9. 1999
  6. pmc Occupational exposure to formaldehyde, hematotoxicity, and leukemia-specific chromosome changes in cultured myeloid progenitor cells
    Luoping Zhang
    School of Public Health, University of California at Berkeley, Berkeley, California 94720, USA
    Cancer Epidemiol Biomarkers Prev 19:80-8. 2010
  7. ncbi Reduced number of circulating endothelial progenitor cells predicts future cardiovascular events: proof of concept for the clinical importance of endogenous vascular repair
    Caroline Schmidt-Lucke
    Molecular Cardiology, Department of Medicine III, J W Goethe University, Frankfurt, Germany
    Circulation 111:2981-7. 2005
  8. pmc Use of the complete blood cell count in early-onset neonatal sepsis
    Christoph P Hornik
    Department of Pediatrics, Duke University, Durham, NC 27715, USA
    Pediatr Infect Dis J 31:799-802. 2012
  9. pmc High hemocyte load is associated with increased resistance against parasitoids in Drosophila suzukii, a relative of D. melanogaster
    Balint Z Kacsoh
    Biology Department, Emory University, Atlanta, Georgia, United States of America
    PLoS ONE 7:e34721. 2012
  10. ncbi The complete blood cell count: a powerful diagnostic tool
    Anne M Barger
    Department of Pathology, University of Illinois, College of Veterinary Medicine, 1008 Hazelwood Drive, Urbana, IL 61801, USA
    Vet Clin North Am Small Anim Pract 33:1207-22. 2003

Detail Information

Publications235 found, 100 shown here

  1. ncbi Haemotoxicity of thiamphenicol in the BALB/c mouse and Wistar Hanover rat
    J A Turton
    Centre for Toxicology, Department of Pharmacology, The School of Pharmacy, University of London, 29 39 Brunswick Square, UK
    Food Chem Toxicol 40:1849-61. 2002
    ..We conclude that TAP induced haematological changes in the mouse and rat, parallelling the dose-dependent, reversible marrow depression reported in man; TAP is more haemotoxic in the rat than in the mouse...
  2. ncbi Red cell distribution width in patients with prehypertension and hypertension
    Asli Tanindi
    Department of Cardiology, Cankiri State Hospital, Aksu mahallesi, Ogretmenler, Sokak, Cankiri, Turkey
    Blood Press 21:177-81. 2012
    ....
  3. pmc Eosinophil count and neutrophil-lymphocyte count ratio as prognostic markers in patients with bacteremia: a retrospective cohort study
    Roser Terradas
    Department of Epidemiology and Health Services Evaluation, Hospital del Mar, Barcelona, Espana
    PLoS ONE 7:e42860. 2012
    ..The aim of this study was to evaluate whether changes in eosinophil count, as well as the neutrophil-lymphocyte count ratio (NLCR), could be used as clinical markers of outcome in patients with bacteremia...
  4. ncbi The value of a complete blood count in predicting cancer of the colon
    Derrick W Spell
    Department of Internal Medicine, Division of Hematology Oncology, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0565, USA
    Cancer Detect Prev 28:37-42. 2004
    ..The red cell distribution width was 84% sensitive and 88% specific for right-sided colon cancer. An elevated red cell distribution width may help better identify those patients who should be referred for full colonoscopy...
  5. ncbi Acute inflammatory responses in the airways and peripheral blood after short-term exposure to diesel exhaust in healthy human volunteers
    S Salvi
    University Medicine Department, Southampton General Hospital, Southampton, and Cardiovascular Research, The Rayne Institute, St Thomas Hospital, London, United Kingdom
    Am J Respir Crit Care Med 159:702-9. 1999
    ....
  6. pmc Occupational exposure to formaldehyde, hematotoxicity, and leukemia-specific chromosome changes in cultured myeloid progenitor cells
    Luoping Zhang
    School of Public Health, University of California at Berkeley, Berkeley, California 94720, USA
    Cancer Epidemiol Biomarkers Prev 19:80-8. 2010
    ....
  7. ncbi Reduced number of circulating endothelial progenitor cells predicts future cardiovascular events: proof of concept for the clinical importance of endogenous vascular repair
    Caroline Schmidt-Lucke
    Molecular Cardiology, Department of Medicine III, J W Goethe University, Frankfurt, Germany
    Circulation 111:2981-7. 2005
    ..Circulating EPCs may thus provide an endogenous repair mechanism to counteract ongoing risk factor-induced endothelial injury and to replace dysfunctional endothelium...
  8. pmc Use of the complete blood cell count in early-onset neonatal sepsis
    Christoph P Hornik
    Department of Pediatrics, Duke University, Durham, NC 27715, USA
    Pediatr Infect Dis J 31:799-802. 2012
    ..The complete blood cell count and differential have been previously evaluated as diagnostic tools for EOS in small, single-center reports...
  9. pmc High hemocyte load is associated with increased resistance against parasitoids in Drosophila suzukii, a relative of D. melanogaster
    Balint Z Kacsoh
    Biology Department, Emory University, Atlanta, Georgia, United States of America
    PLoS ONE 7:e34721. 2012
    ..Given that D. suzukii is an emerging agricultural pest, identification of the few parasitoid wasps that successfully infect D. suzukii may have value for biocontrol...
  10. ncbi The complete blood cell count: a powerful diagnostic tool
    Anne M Barger
    Department of Pathology, University of Illinois, College of Veterinary Medicine, 1008 Hazelwood Drive, Urbana, IL 61801, USA
    Vet Clin North Am Small Anim Pract 33:1207-22. 2003
    ..To gain the full benefit of the CBC, it must be used in conjunction with a good history and physical examination as well as with additional components of the minimum database, which include a chemistry panel and urinalysis...
  11. ncbi Validation of the Sysmex XT-2000iV hematology system for dogs, cats, and horses. I. Erythrocytes, platelets, and total leukocyte counts
    Inger Lilliehöök
    University Animal Hospital, Swedish University of Agricultural Sciences, Uppsala, Sweden
    Vet Clin Pathol 38:163-74. 2009
    ..The Sysmex XT-2000iV is a laser-based, flow cytometric hematology system that has been introduced for use in large and referral veterinary laboratories...
  12. ncbi Effect of perinatal antiretroviral drug exposure on hematologic values in HIV-uninfected children: An analysis of the women and infants transmission study
    Susan E Pacheco
    Baylor College of Medicine, Houston, Texas, USA
    J Infect Dis 194:1089-97. 2006
    ..With the increasing use of antiretroviral (ARV) drugs to prevent mother-to-child transmission of human immunodeficiency virus (HIV), large numbers of infants are exposed, with possible consequent toxicity...
  13. pmc Ambient particulate air pollution, heart rate variability, and blood markers of inflammation in a panel of elderly subjects
    C Arden Pope
    Department of Economics, Brigham Young University, Provo, UT 84602, USA
    Environ Health Perspect 112:339-45. 2004
    ..5; however, the small statistically significant associations that were observed suggest that exposure to PM2.5 may be one of multiple factors that influence HRV and CRP...
  14. pmc Mechanisms of mortality in early and late sepsis
    Hongyan Xiao
    Department of Pathology, University of Michigan, 2210 Medical Science I Building, 1301 Catherine Road, Ann Arbor, MI 48109 0602, USA
    Infect Immun 74:5227-35. 2006
    ..Determining the inflammatory status of individual patients may help guide appropriate, targeted therapy...
  15. pmc Complete blood cell count and retinal vessel diameters
    Barbara E K Klein
    Department of Ophthalmology and Visual Sciences, School of Medicine and Public Health, University of Wisconsin Madison, 610 N Walnut Street, Madison, WI 53726 2336, USA
    Arch Ophthalmol 129:490-7. 2011
    To examine the cross-sectional associations of components of the complete blood cell count with retinal vessel diameters.
  16. ncbi Hematologic values in young pretraining healthy Greyhounds
    Robert E Shiel
    Small Animal Clinical Studies Unit, School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland
    Vet Clin Pathol 36:274-7. 2007
    ..The hematologic differences are likely related to breed; however, the influence of other factors, including age, sex, and training, has not been fully determined...
  17. ncbi Age-related variations in hematologic and plasma biochemical test results in Beagles and Labrador Retrievers
    E Jean Harper
    Waltham Centre for Pet Nutrition, Waltham on the Wolds, Melton Mowbray, Leicestershire, LE14 4RT, UK
    J Am Vet Med Assoc 223:1436-42. 2003
    ..To investigate age-related variations in results of hematologic and plasma biochemical tests performed on dogs of 2 common breeds...
  18. ncbi Bone marrow: the workhorse organ
    Jeannette Y Wick
    University of Connecticut School of Pharmacy, Storrs, Connecticut Arlington, Virginia, USA
    Consult Pharm 28:16-22. 2013
    ..Interpreting CBCs depends on reference values from the laboratory that processes the blood sample. Since reference intervals are formulated based on a younger, much healthier population, data specific to elderly people are limited...
  19. ncbi A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation
    A Coxon
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Immunity 5:653-66. 1996
    ..Thus, CD11b/CD18 plays a novel and unsuspected homeostatic role in inflammation by accelerating the programmed elimination of extravasated neutrophils...
  20. ncbi Performance evaluation of the Sysmex pocH-100iV Diff hematology analyzer for analysis of canine, feline, equine, and bovine blood
    Barbara Riond
    Clinical Laboratory, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland
    Vet Clin Pathol 40:484-95. 2011
    ..The Sysmex pocH-100iV Diff is an impedance hematology analyzer recently introduced for point-of-care use in veterinary practices in Europe...
  21. pmc Use of the complete blood cell count in late-onset neonatal sepsis
    Christoph P Hornik
    Department of Pediatrics, Duke University, Durham, NC 27715, USA
    Pediatr Infect Dis J 31:803-7. 2012
    ..Diagnosis of late-onset sepsis can be challenging. The complete blood cell count and differential have been previously evaluated as diagnostic tools for late-onset sepsis in small, single-..
  22. ncbi Sex differences in blood cell counts in the Lothian Birth Cohort 1921 between 79 and 87 years
    John M Starr
    Centre for Cognitive Ageing and Cognitive Epidemiology, Geriatric Medicine, University of Edinburgh, Royal Victoria Hospital, Edinburgh, Scotland, UK
    Maturitas 69:373-6. 2011
    ..In older adults there are few data that inform about normal ranges and the change in blood cell counts with ageing. These few data indicate that sex differences in blood cell counts persist beyond 70 years...
  23. ncbi The effect of pneumatic tube system on complete blood count parameters and thrombocyte donation in healthy donors
    Ismail Sari
    Department of Hematology, Pamukkale University, Faculty of Medicine, Denizli, Turkey
    Transfus Apher Sci 47:81-3. 2012
    ..No statistically significant differences were observed in order to mean values of routine complete blood cell count and white cell differential parameters that were send for selection of apheresis donor before the procedure...
  24. ncbi Evaluation of the automated hematology analyzer Sysmex XT-2000iV™ compared to the ADVIA® 2120 for its use in dogs, cats, and horses: Part I--precision, linearity, and accuracy of complete blood cell count
    Natali Bauer
    Department of Veterinary Clinical Sciences, Clinical Pathology and Clinical Pathophysiology, Justus Liebig University Giessen, Frankfurterstr 129, 35392 Giessen, Germany Natali
    J Vet Diagn Invest 23:1168-80. 2011
    The automated laser-based hematology analyzer Sysmex XT-2000iV™ providing a complete blood cell count (CBC) and 5-part differential has been introduced in large veterinary laboratories...
  25. ncbi How to interpret and pursue an abnormal complete blood cell count in adults
    Ayalew Tefferi
    Department of Internal Medicine and Division of Hematology, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Mayo Clin Proc 80:923-36. 2005
    A complete blood cell count (CBC) is one of the most common laboratory tests in medicine. For example, at our institution alone, approximately 1800 CBCs are ordered every day, and 10% to 20% of results are reported as abnormal...
  26. ncbi Evaluation of the impedance analyzer PocH-100iV Diff for analysis of canine and feline blood
    Natali B Bauer
    Department of Veterinary Clinical Sciences, Clinical Pathology and Clinical Pathophysiology, Justus Liebig University, Giessen, Germany
    Vet Clin Pathol 41:194-206. 2012
    ..An automated impedance-based in-house hematology analyzer, the PocH-100iV Diff, which provides a 3-part leukocyte differential count that includes eosinophils, recently has been introduced...
  27. ncbi Quality specification in haematology: the automated blood cell count
    Mauro Buttarello
    Servizio di Medicina di Laboratorio, Azienda Ospedaliera, Via Giustiniani 2, 35128, Padova, Italy
    Clin Chim Acta 346:45-54. 2004
    ..Quality specifications for automated blood cell counts include topics that go beyond the traditional analytic stage (imprecision, inaccuracy, quality control) and extend to pre- and post-analytic phases...
  28. ncbi Comparison of performance characteristics between first- and third-generation hematology systems
    P W Barnes
    Clinical Hematology, Department of Laboratories, Barnes Jewish Hospital, One Barnes Jewish Plaza, St Louis, MO 63110, USA
    Lab Hematol 11:298-301. 2005
    ..The improvements in overall operating costs (> dollar 195,000) were also maintained. Payback was not considered since this was a replacement of our previous system, which had already eliminated more than 6 FTEs...
  29. pmc Comparative clinical study of canine and feline total blood cell count results with seven in-clinic and two commercial laboratory hematology analyzers
    Martina Becker
    Department of Veterinary Clinical Sciences, Clinical Pathology, and Clinical Pathophysiology, Justus Liebig University Giessen, Germany
    Vet Clin Pathol 37:373-84. 2008
    ..While in the past newer technologies for CBC analysis were limited to large clinical pathology laboratories, several smaller and affordable automated hematology analyzers have been developed for in-clinic use...
  30. pmc Acute leukemia with promyelocytic features in PML/RARalpha transgenic mice
    L Z He
    Department of Human Genetics, Memorial Sloan Kettering Cancer Center, Molecular Biology and Cell Biology Programs, Sloan Kettering Institute, 1275 York Avenue, New York, NY, 10021, USA
    Proc Natl Acad Sci U S A 94:5302-7. 1997
    ..Our results are conclusive in vivo evidence that PML/RARalpha plays a crucial role in the pathogenesis of APL...
  31. ncbi Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBP alpha
    Pu Zhang
    Harvard Institutes of Medicine, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Immunity 21:853-63. 2004
    ..Therefore, C/EBP alpha is not only essential for granulocyte development but, in addition, is a regulator of hematopoietic stem cell activity...
  32. ncbi Hematological reference ranges in black very low birth weight infants
    V P Stancheva
    Department of Haematology and Molecular Medicine, South African Institute for Medical Research and University of the Witwatersrand, Johannesburg
    Pediatr Hematol Oncol 19:91-4. 2002
    ..The hematological parameters observed in black very low birth weight neonates are similar to previously published reference ranges, except that lower limits of normal were observed for hemoglobin and the red cell indices...
  33. pmc Examination of peripheral blood films using automated microscopy; evaluation of Diffmaster Octavia and Cellavision DM96
    H Ceelie
    Department of Clinical Chemistry, Albert Schweitzer Ziekenhuis, Dordrecht, The Netherlands
    J Clin Pathol 60:72-9. 2007
    ..These computerised systems provide an automated morphological analysis of peripheral blood films, including a preclassification of both red and white cells (RBCs and WBCs, respectively)...
  34. ncbi Complete blood cell count as a surrogate CD4 cell marker for HIV monitoring in resource-limited settings
    Ray Y Chen
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
    J Acquir Immune Defic Syndr 44:525-30. 2007
    ..We developed a more effective method based on a decision tree algorithm to classify subjects...
  35. pmc Effect of abrupt weaning at housing on leukocyte distribution, functional activity of neutrophils, and acute phase protein response of beef calves
    E M Lynch
    Animal and Bioscience Research Department, Animal and Grassland Research and Innovation Centre, Teagasc, Grange, Dunsany, Co Meath, Ireland
    BMC Vet Res 6:39. 2010
    ....
  36. ncbi Measurement of haemoglobin as a screening test in general practice
    S M Lewis
    WHO Collaborating Centre for Haematology Technology, Department of Haematology, Imperial College, Hammersmith Hospital, London W12 0NN, UK
    J Med Screen 11:103-5. 2004
    ..To assess the validity of using the measurement of haemoglobin as a primary screen test at point-of-care in general practice...
  37. ncbi Acute effects of fine particles on cardiovascular system: differences between the spontaneously hypertensive rats and wistar kyoto rats
    Jinzhuo Zhao
    Department of Environment Health, School of Public Health, Fudan University, Shanghai, China
    Toxicol Lett 193:50-60. 2010
    ..Different response between SHR and WKY rats after exposed to fine particles indicated that SHR was more susceptible than WKY rats to acute cardiac impairments from fine particle exposure...
  38. ncbi Peripheral-blood dendritic cells in men with coronary heart disease
    Hongyu Shi
    Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, People s Republic of China
    Am J Cardiol 100:593-7. 2007
    ..01). In conclusion, total peripheral-blood DCs are significantly higher in patients with CAD because of an increase in mDC subset, which might contribute to enhanced Th1 response in patients with CAD...
  39. ncbi Mechanisms of HDAC inhibitor-induced thrombocytopenia
    Hideaki Matsuoka
    Pharmacology Research Laboratories, Astellas Pharma Inc, 2 1 6 Kashima, Yodogawa ku, Osaka 532 8514, Japan
    Eur J Pharmacol 571:88-96. 2007
    ..Our findings may help our understanding of the molecular mechanism of HDAC inhibitor-mediated GATA-1 transcriptional repression and to reduce the risk of HDAC inhibitor-induced thrombocytopenia...
  40. pmc Immunohematological reference ranges for adults from the Central African Republic
    Didier Menard
    Institut Pasteur de Bangui, Bangui, Central African Republic
    Clin Diagn Lab Immunol 10:443-5. 2003
    ..Thus, the CD4/CD8 T-cell ratios for healthy adults from the CAR are significantly reduced compared to the ratios for healthy Europeans...
  41. ncbi Relationships between blood rheology and age, body mass index, blood cell count, fibrinogen, and lipids in healthy subjects
    Koji Seki
    Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan
    Clin Hemorheol Microcirc 34:401-10. 2006
    ..9+/-11.3 years) were participated in this study. Body weight, body mass index, red blood cell count, hematocrit, hemoglobin, white blood cell count, and platelet count, plasma fibrinogen, and fasting serum ..
  42. pmc Which observations from the complete blood cell count predict mortality for hospitalized patients?
    Abel N Kho
    Regenstrief Institute, Inc
    J Hosp Med 2:5-12. 2007
    ..Information on the prognostic utility of the admission complete blood count (CBC) and differential count is lacking...
  43. ncbi Short telomeres, even in the presence of telomerase, limit tissue renewal capacity
    Ling Yang Hao
    Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 123:1121-31. 2005
    ..We propose that short telomeres in mice that have normal telomerase levels can cause an occult form of genetic disease...
  44. pmc Full blood count and haemozoin-containing leukocytes in children with malaria: diagnostic value and association with disease severity
    Thomas Hanscheid
    Medical Research Unit, Albert Schweitzer Hospital, Lambarene, Gabon
    Malar J 7:109. 2008
    ..Diligent and correct laboratory diagnosis and up-front identification of risk factors for progression to severe disease are the basis for optimal management of malaria...
  45. pmc The effect of road and sea transport on inflammatory, adrenocortical, metabolic and behavioural responses of weanling heifers
    Bernadette Earley
    Animal and Bioscience Research Department, Animal and Grassland Research and Innovation Centre, Teagasc, Grange, Dunsany, Co Meath, Ireland
    BMC Vet Res 6:36. 2010
    ..The objective was to investigate the effect of transport on inflammatory, adrenocortical, metabolic and behavioural responses of weanling heifers transported from Ireland to Spain...
  46. ncbi Performance evaluation of the Sysmex XS-1000i automated haematology analyser
    T Ghys
    Clinical Laboratory Middelheim, AZ Middelheim, Lindendreef 1, 2020 Antwerp, Belgium
    Int J Lab Hematol 31:560-6. 2009
    ..In conclusion, the Sysmex XS-1000i demonstrated good analytical performance, is able to generate a complete blood count with five-part differential on low blood volumes and has considerable back-up capacity...
  47. ncbi Optimizing outcomes in damage control resuscitation: identifying blood product ratios associated with improved survival
    Oliver L Gunter
    Department of General Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Trauma 65:527-34. 2008
    ..The purpose of this study was to evaluate whether suggested blood product ratios yield superior survival rates...
  48. ncbi Pathophysiological principles underlying the blood cell concentration responses used to assess the severity of effect after accidental whole-body radiation exposure: an essential basis for an evidence-based clinical triage
    Theodor M Fliedner
    Radiation Medicine Research Group, University of Ulm, Ulm, Germany
    Exp Hematol 35:8-16. 2007
    ....
  49. ncbi Validation of the Coulter LH 750 in a hospital reference laboratory
    C Aulesa
    Laboratories Unit, Valle de Hebron Hospital Complex, Barcelona, Spain
    Lab Hematol 9:15-28. 2003
    ..In conclusion, we analyzed the impact and improvements that may be expected in our laboratory (a user of Technicon and Coulter instruments) from introducing the new LH 750 analyzer into our routine...
  50. ncbi Performance evaluation of the latest fully automated hematology analyzers in a large, commercial laboratory setting: a 4-way, side-by-side study
    G Bourner
    Gamma Dynacare, Gamma Dynacare Medical Laboratories, 115 Midair Court Brampton, Ontario L6T 5M3, Canada
    Lab Hematol 11:285-97. 2005
    ..Our 4-way evaluation resulted in selection of the Beckman Coulter LH 750 for Gamma-Dynacare Laboratories because it enabled the lowest slide review rate and handled aged samples better than the other analyzers...
  51. ncbi Usefulness of cell counter-based parameters and formulas in detection of beta-thalassemia trait in areas of high prevalence
    Dinesh A Rathod
    Departments of Pathology, Smt NHL Municipal Medical College, Ahmedabad, India
    Am J Clin Pathol 128:585-9. 2007
    ..We found that the Shine and Lal, Srivastava, and Mentzler indexes, MCV, and MCH have better discriminative function than the RBC count and red cell distribution width and their related formulas...
  52. ncbi Reduced number of circulating endothelial progenitor cells in hypogonadal men
    C Foresta
    Department of Histology, Microbiology, and Medical Biotechnologies, Centre for Male Gamete Cryopreservation, University of Padova, Padova, Italy
    J Clin Endocrinol Metab 91:4599-602. 2006
    ..Even though there is increasing evidence that estrogens play a beneficial role on EPCs and, even if debated, on the cardiovascular system, less is known about androgens...
  53. ncbi Automated malaria diagnosis using pigment detection
    T Hanscheid
    Laboratorio de Bacteriologia, Piso 4, Patologia Clinica, Hospital de Santa Maria, P 1600, Lisboa, Portugal
    Parasitol Today 16:549-51. 2000
    ..Thomas Hänscheid, Emilia Valadas and Martin Grobusch here describe this novel technique for malaria diagnosis and discuss its potential applications...
  54. ncbi The international consensus group for hematology review: suggested criteria for action following automated CBC and WBC differential analysis
    P W Barnes
    Clinical Hematology, Department of Laboratories, Barnes Jewish Hospital, St Louis, Missouri, USA
    Lab Hematol 11:83-90. 2005
    ..To facilitate validating these rules in individual laboratories before implementation in routine operation for patient samples, a suggested protocol is attached to this paper...
  55. ncbi Evaluation of the ruminant complete blood cell count
    Meredyth L Jones
    Department of Clinical Sciences, 111B Mosier Hall, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA
    Vet Clin North Am Food Anim Pract 23:377-402, v. 2007
    The complete blood cell count can provide valuable diagnostic and prognostic information when coupled with a thorough physical examination...
  56. ncbi Patients with myelodysplastic syndromes benefit from palliative therapy with amifostine, pentoxifylline, and ciprofloxacin with or without dexamethasone
    A Raza
    Rush Cancer Institute and the Departments of Pathology and Biostatistics, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612 3515, USA
    Blood 95:1580-7. 2000
    ..Blood. 2000;95:1580-1587)..
  57. ncbi Effects of road transportation on lymphocyte subsets in calves
    Fulvio Riondato
    Dipartimento di Patologia Animale, Universita di Torino, Grugliasco TO, Italy
    Vet J 175:364-8. 2008
    ..NK cell expansion, together with increasing lymphocyte count and increasing major histocompatibility complex class II expression, may indicate stress-induced stimulation of the immune system...
  58. ncbi Soluble TNF receptor fusion protein (etanercept) for the treatment of myelodysplastic syndrome: a pilot study
    H J Deeg
    Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Leukemia 16:162-4. 2002
    ..Thus, etanercept treatment resulted in moderate improvements of cytopenias in some patients, while cell counts declined in others. Additional trials are needed to evaluate its clinical efficacy in MDS...
  59. ncbi Hematologic values in healthy and small for gestational age newborns
    M Maconi
    Clinical Pathology Department, AO Arcispedale Santa Maria Nuova, Reggio Emilia, Italy
    Lab Hematol 11:152-6. 2005
    ..These findings further support the fact that preterm SGA infants are truly growth restricted, whereas term SGA infants are most likely small but otherwise healthy babies...
  60. ncbi Short- and long-term haematological surveillance of healthy donors of allogeneic peripheral haematopoietic progenitors mobilized with G-CSF: a single institution prospective study
    C Tassi
    Transfusion Medicine Service, Sant Orsola Hospital, Bologna, Italy
    Bone Marrow Transplant 36:289-94. 2005
    ..14 donors showed persistent, slight lymphocytopenia (mean drop of 13%) until the third year, with recovery in the fourth year of follow-up...
  61. ncbi Effects of diesel exhaust enriched concentrated PM2.5 in ozone preexposed or monocrotaline-treated rats
    F R Cassee
    National Institute of Public Health and the Environment, PO Box 1, NL 3720 BA Bilthoven, The Netherlands
    Inhal Toxicol 14:721-43. 2002
    ..In addition, CDP has the potential to induce changes in blood. It has not yet been determined how the effects seen with CDP would compare to similar levels of ambient particles...
  62. pmc Detection of imported malaria with the Cell-Dyn 4000 hematology analyzer
    Peter C Wever
    Section of Parasitology, Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Clin Microbiol 40:4729-31. 2002
    ..5%. Attention to these abnormalities in medical centers without tropical disease expertise may decrease a delay in the diagnosis of malaria...
  63. ncbi Laboratory productivity and the rate of manual peripheral blood smear review: a College of American Pathologists Q-Probes study of 95,141 complete blood count determinations performed in 263 institutions
    David A Novis
    Department of Pathology, Wentworth Douglass Hospital, Dover, NH, USA
    Arch Pathol Lab Med 130:596-601. 2006
    ..The frequency with which hematology laboratory workers perform manual screens despite the availability of labor-saving features of automated analyzers is unknown...
  64. ncbi Endothelin levels in Henoch-Schonlein purpura
    Ali Muslu
    Ondokuz Mayis University, School of Medicine, Department of Pediatrics, 55139 Samsun, Turkey
    Pediatr Nephrol 17:920-5. 2002
    ..There was no correlation between ET-1 levels and disease severity, acute phase reactant response, or morbidity. The role of endothelins and other cytokines in the pathogenesis of HSP needs to be further explored...
  65. ncbi Effect of 12-hour road transportation on physiological, immunological and haematological parameters in bulls housed at different space allowances
    S Gupta
    Teagasc, Grange Research Centre, Dunsany, Co Meath, Ireland
    Vet J 173:605-16. 2007
    ..Furthermore, transport of bulls housed at increased space allowance (4.2m(2)/bull) resulted in a greater plasma cortisol response, albeit still within normal physiological range...
  66. ncbi Changes in automated complete blood cell count and differential leukocyte count results induced by storage of blood at room temperature
    Gene L Gulati
    Department of Pathology, Anatomy, and Cell Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA, USA
    Arch Pathol Lab Med 126:336-42. 2002
    To delineate changes that occur in various parameters of automated complete blood cell count (CBC) and differential leukocyte count (differential) on prolonged storage of blood at room temperature.
  67. ncbi Analysis of factors associated with low peripheral blood progenitor cell collection in normal donors
    Javier de la Rubia
    Hematology Service, Hospital La Fe, Valencia, Spain
    Transfusion 42:4-9. 2002
    ..Predictive factors of the response to rHuG-CSF in normal donors have not been extensively studied...
  68. pmc Donor demographic and laboratory predictors of allogeneic peripheral blood stem cell mobilization in an ethnically diverse population
    Sumithira Vasu
    Department of Transfusion Medicine, Warren Grant Magnuson Clinical Center, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 112:2092-100. 2008
    ..Age, white ethnicity, and female gender were associated with significantly lower post-G-CSF CD34(+) cell counts...
  69. ncbi Sensitivity of laser light depolarization analysis for detection of malaria in blood samples
    Manuel Martínez Padial
    Laboratory of Microbiology and Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain
    J Med Microbiol 54:449-52. 2005
    ....
  70. ncbi Peripheral blood circulating immature cell counts predict CD34+ cell yields in G-CSF-induced PBPC mobilization in healthy donors
    Teruhiko Kozuka
    Second Department of Internal Medicine, Division of Blood Transfusion, Okayama University Medical School, Japan
    Transfusion 44:526-32. 2004
    ..The correlation of CIC counts in PB with CD34+ cell yield and its usefulness was evaluated in G-CSF-induced PBPC mobilization for healthy donors...
  71. ncbi Differential counting of blood leukocytes using automated microscopy and a decision support system based on artificial neural networks--evaluation of DiffMaster Octavia
    B Swolin
    Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Goteborg University, Sweden
    Clin Lab Haematol 25:139-47. 2003
    ..In conclusion this study shows that the DiffMaster can provide a decision support system which, together with a qualified morphologist, can generate leukocyte differential count reports of high quality...
  72. ncbi Exposure of mice to concentrated ambient particulate matter results in platelet and systemic cytokine activation
    D W Wilson
    Department of Pathology, Microbiology and Immunology, University of California Davis, Davis, California 95616, USA
    Inhal Toxicol 22:267-76. 2010
    ....
  73. ncbi Haemocyte changes in D. Melanogaster in response to long gland components of the parasitoid wasp Leptopilina boulardi: a Rho-GAP protein as an important factor
    C Labrosse
    Institut de Recherche sur la Biologie de l Insecte UMR CNRS 6035, Université F Rabelais, Parc Grandmont, 37 200 Tours, France
    J Insect Physiol 51:161-70. 2005
    ..The implication of the P4 protein in suppressing the host cellular immunity is discussed in correlation with its predicted molecular function as a Rho-GAP protein...
  74. ncbi The effect of repeated acute mental stress on habituation and recovery responses in hemoconcentration and blood cells in healthy men
    Katharina Mischler
    Institute for Behavioral Sciences, Federal Institute of Technology, Zurich, Switzerland
    Life Sci 77:1166-79. 2005
    ..Plasma volume shift accompanying stress affects the time course of stress polycytosis...
  75. ncbi Changes in hematology, biochemical values, and restraint ECG of rhesus monkeys (Macaca mulatta) following 6-month laboratory acclimation
    Masatoshi Hassimoto
    Toxicology Laboratory, Research Center, Mochida Pharmaceutical Co, Ltd, Shizuoka, Japan
    J Med Primatol 33:175-86. 2004
    ..Current results show that an acclimation period at least 3 months may be necessary prior to using rhesus monkeys for chronic studies...
  76. ncbi Four week feeding toxicity study with phenylphosphinic acid in rats
    E Maria Donner
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714 0050, USA
    Drug Chem Toxicol 26:125-33. 2003
    ..Parameters measured were clinical signs, growth, neurobehavior, ophthalmology, and clinical and anatomical pathology. Phenylphosphinic acid is very low in toxicity following 31 days of feeding to the rat...
  77. ncbi Up-and-down procedure (UDP) determinations of acute oral toxicity of nitroso degradation products of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX)
    Sharon A Meyer
    Department of Toxicology, University of Louisiana at Monroe, Monroe, LA 71209, USA
    J Appl Toxicol 25:427-34. 2005
    ....
  78. ncbi Hematological parameters and anaerobic threshold in Brazilian soccer players throughout a training program
    A S R Silva
    Department of Physical Education, Bioscience Institute, University of Sao Paulo State Unesp, Rio Claro, Sao Paulo, Brazil
    Int J Lab Hematol 30:158-66. 2008
    ..Furthermore, we did not observe any correlation between the anaerobic threshold and the hematological parameters...
  79. ncbi Sensitivity of Atlantic salmon (Salmo salar) to dietary endosulfan as assessed by haematology, blood biochemistry, and growth parameters
    Dietrich Petri
    National Institute of Nutrition and Seafood Research, Postbox 2029 Nordnes, 5817 Bergen, Norway
    Aquat Toxicol 80:207-16. 2006
    ..The present study shows that with regards to acute toxicity, Atlantic salmon are able to tolerate dietary technical endosulfan levels up to 500 microg kg(-1)...
  80. ncbi Effects of dietary benzo[a]pyrene on growth and hematological parameters in juvenile rockfish, Sebastes schlegeli (Hilgendorf)
    Seong Gil Kim
    Marine Environmental Management Team, National Fisheries Research and Development Institute, Busan 619 902, South Korea
    Bull Environ Contam Toxicol 81:470-4. 2008
    ..Over 30 days, serum AST increased at a B[a]P concentration of 1.5 mg/kg and LDH increased at a B[a]P concentration of 1.0 mg/kg concentration. However, no changes were observed in ALT, total protein, magnesium or calcium...
  81. ncbi Decreased hemoglobin levels are associated with higher plasma level of fibrinogen, irrespective of age
    Ludovico Coppola
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
    Am J Med Sci 333:154-60. 2007
    ..We aimed at verifying whether the changes of fibrinogen levels are associated with red blood cell (and/or hemoglobin) concentration...
  82. ncbi Blood biochemical and ruminal liquor profile in buffaloes (Bubalus bubalis) showing omasal impaction
    S Turkar
    Division of Veterinary Medicine, Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, 243 122, India
    Vet Res Commun 31:967-75. 2007
    ..The ruminal liquor of the diseased buffaloes revealed characteristic physical, chemical and microbial changes and had significantly higher methylene blue reduction time and ammonia-nitrogen level...
  83. ncbi Changes in hemopoietic precursors after treatment of low-risk myelodysplasia with amifostine
    Elisangela Ribeiro
    Department of Internal Medicine, Faculty of Medicine, State University of Campinas, Brazil
    In Vivo 17:181-4. 2003
    ..Clinical studies have shown that amifostine (AMF) improves peripheral cytopenias in myelodysplastic syndromes (MDS). We studied the expression of Fas/FasL on CD34+ cells in low risk MDS and its change after AMF treatment...
  84. ncbi [Establishing the reference range of venous blood measured by automated haematology analyzer in Chinese adults]
    Yu Long Cong
    Department of Clinical Laboratory, Chinese PLA General Hospital, Beijing 100853, China
    Zhonghua Yi Xue Za Zhi 83:1201-5. 2003
    ..To establish the reference range of venous blood measured by automated hematology analyzer in China...
  85. ncbi Royal jelly supplementation improves lipoprotein metabolism in humans
    Hang Guo
    R and D Center, Nippon Meat Packers, Inc, Ibaraki, Japan
    J Nutr Sci Vitaminol (Tokyo) 53:345-8. 2007
    ..Among the lipoprotein fractions, small very-low-density lipoprotein was decreased (p<0.05) after RJ intake. Our results suggest that dietary RJ decreases TC and LDL by lowering small VLDL levels...
  86. ncbi Effects of training and strenuous exercise on hematologic values and peripheral blood leukocyte subsets in racing sled dogs
    Michael S Davis
    Comparative Exercise Physiology Laboratory, 264 McElroy Hall, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74078, USA
    J Am Vet Med Assoc 232:873-8. 2008
    ..To determine the effects of training and sustained submaximal exercise on hematologic values in racing sled dogs...
  87. ncbi Normal haematology and blood biochemistry of wild Nile crocodiles (Crocodylus niloticus) in the Okavango Delta, Botswana
    C J Lovely
    Gobabis Veterinary Practise, PO Box 1424, Gobabis, Namibia
    J S Afr Vet Assoc 78:137-44. 2007
    ..The values reported here will be useful in diagnostic investigations in both zoo and farmed Nile crocodiles...
  88. ncbi Some clinico-pathological changes associated with the aqueous extract of the leaves of Phyllanthus amarus in rats
    A A Adedapo
    Department of Veterinary Physiology and Pharmacology, University of Ibadan, Nigeria
    Phytother Res 19:971-6. 2005
    ..A reduction in the weight of the experimental animals was also noted in this study. It thus shows that Phyllanthus amarus has potential toxic properties...
  89. ncbi Reduction in hematocrit and hemoglobin following pioglitazone treatment is not hemodilutional in Type II diabetes mellitus
    R Berria
    Division of Diabetes, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA
    Clin Pharmacol Ther 82:275-81. 2007
    ..02) counts was seen after PIO. In conclusion, the small decreases in Hb/Hct observed after 16 weeks of PIO treatment cannot be explained by an increase in TBW. Other causes, such a mild marrow suppressive effect, should be explored...
  90. ncbi Influence of porcine coat colour genotypes on haematological parameters, piglet birth weight and body weight gain until weaning
    L Fesus
    Research Institute for Animal Breeding and Nutrition, Herceghalom, Hungary
    J Anim Breed Genet 122:127-30. 2005
    ..Ellegren, L. Marklund, U. Gustavsson, E. Ringmar-Cederberg, K. Andersson, I. Edfors-Lilja and L. Andersson [(1992) Genomics, 14, 965] that the pleiotrophic effect of the porcine KIT mutations on haematopoietic cells must be mild...
  91. ncbi Using haematological parameters to infer the health and nutritional status of an endangered black-necked swan population
    Paulina Artacho
    Instituto de Ecologia y Evolucion, Facultad de Ciencias, Universidad Austral de Chile, Chile
    Comp Biochem Physiol A Mol Integr Physiol 147:1060-6. 2007
    ..reduced 30%, which was followed by significant reductions of haemoglobin concentration, haematocrit and red blood cell count. Mean cell volume and mean cell haemoglobin concentration did not change with time, whereas there was a ..
  92. ncbi Effects of methanol extracts of Caesalpinia bonducella and Bauhinia racemosa on hematology and hepatorenal function in mice
    Ramanathan Sambath Kumar
    Division of Pharmacology and Pharmaceutical Chemistry, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India
    J Toxicol Sci 30:265-74. 2005
    ..Our results suggested that MECB and MEBR at doses 100 and 200 mg/kg body weight did not induce any toxic effects in the mice. Adverse effect was noted at the dose of 400 mg/kg body weight...
  93. ncbi Biochemical and hematologic values for 18 clinically healthy radiated tortoises (Geochelone radiata) on St Catherines Island, Georgia
    Julia Zaias
    University of Miami, Department of Pathology, Division of Comparative Pathology and Avian and Wildlife Diagnostic Laboratory, Miami, FL, USA
    Vet Clin Pathol 35:321-5. 2006
    ..Captive breeding programs have generated data on the breeding behavior and ecology of G radiata; however, hematologic and biochemical data also are critically important in managing populations...
  94. ncbi Immunotoxicity of sodium bromate in female B6C3F1 mice: a 28-day drinking water study
    T L Guo
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, PO Box 980613, Richmond, VA 23298-0613, USA
    Drug Chem Toxicol 24:129-49. 2001
    ..In conclusion, SB, when administered in the drinking water at doses from 80 mg/l to 800 mg/l, produced minimal toxicological and immunotoxic effects in female B6C3F1 mice...
  95. ncbi Hematologic and plasma biochemical analysis of juvenile head-started northern red-bellied cooters (Pseudemys rubriventris)
    Charles J Innis
    New England Aquarium, Central Wharf, Boston, Massachusetts 02110, USA
    J Zoo Wildl Med 38:425-32. 2007
    ..Basophils were the most numerous type of leucocyte. Results for some values varied significantly between institutions, possibly due to unrecognized differences in husbandry at each facility...
  96. ncbi Haematological characterization of loach Misgurnus anguillicaudatus: comparison among diploid, triploid and tetraploid specimens
    Zexia Gao
    College of Fishery, Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan, Hubei, 430070, PR China
    Comp Biochem Physiol A Mol Integr Physiol 147:1001-8. 2007
    ..Overall, loach with higher ploidy levels showed evidence of some advantages in haematological characteristics...
  97. ncbi Clinical impact of a new automated system employed for peripheral blood stem cell collection
    Claudia Del Fante
    Immunohaematology and Transfusion Service, Center for Transplant Immunology, IRCCS Policlinico S Matteo, Pavia, Italy
    J Clin Apher 21:227-32. 2006
    ..Moreover, the ability to predict the CD34(+) cell yield permits improved management of the leukapheresis collection, with the only disadvantage of larger leukapheresis volume and higher hematocrit...
  98. ncbi Pluripotent and myeloid-committed CD34+ subsets in hematopoietic stem cell allografts
    K Theilgaard-Monch
    Department of Hematology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Bone Marrow Transplant 32:1125-33. 2003
    ..Finally, this study reports a new gating strategy for the enumeration of pluripotent CD34(+)CD38(-) subsets...
  99. ncbi Murine side population cells contain cobblestone area-forming cell activity in mobilized blood
    Kalindi Parmar
    Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Stem Cells Dev 14:452-61. 2005
    ..This model offers a means to study the mechanisms of mobilization of primitive stem cells directly in a murine model...
  100. ncbi Optimising parameters for peripheral blood leukapheresis after r-metHuG-CSF (filgrastim) and r-metHuSCF (ancestim) in patients with multiple myeloma: a temporal analysis of CD34(+) absolute counts and subsets
    I H Chin-Yee
    London Health Sciences Centre, London, ON, Canada
    Bone Marrow Transplant 30:851-60. 2002
    ..5%) and three (37.5%) achieved the target dose with two leukaphereses. Use of this mobilization strategy allowed the collection of high numbers of CD34(+) cells and early progenitors and the ability to predictably schedule leukapheresis...
  101. ncbi Maternal plasma or human serum albumin in wash buffer enhances enrichment and ex vivo expansion of human umbilical cord blood CD34+ cells
    Yvonne K Kwok
    Department of Obstetrics and Gynaecology, The University of Hong Kong, Hong Kong
    Br J Haematol 137:468-74. 2007
    ..No statistical significance was found between using HSA and maternal plasma on total cell and CD34+ cell expansion. We propose that HSA in maternal plasma was responsible for the positive effect on CD34+ cell enrichment and expansion...

Research Grants66

  1. Identification and Significance of Biologic Mediators in Red Cell Concentrates
    Richard P Phipps; Fiscal Year: 2012
    ..Laboratory measures include CD40 ligand, C-reactive protein, D-dimer, blood cell count and differential...
  2. The role of CD8+ T cells in response to EBV-induced infectious mononucleosis
    Oludare A Odumade; Fiscal Year: 2010
    ..Diagnostic blood smears show abnormal circulating cytotoxic T cells and an elevated white blood cell count. The link between cancer and Epstein Barr viral genes has been well studied but yet little is known about ..
  3. Treatment with KZ-41 and OTP promotes wound healing in a radiation combined injur
    MOSTAFA GABER; Fiscal Year: 2009
    ..has potent vascular anti-inflammatory effects, promotes vascular recovery from injury, and increases white blood cell count, making it an excellent candidate as a potential agent that facilitate tissue recovery and wound repair...
  4. Treatment with KZ-41 and OTP promotes wound healing in a radiation combined injur
    Duane D Miller; Fiscal Year: 2012
    ..has potent vascular anti-inflammatory effects, promotes vascular recovery from injury, and increases white blood cell count, making it an excellent candidate as a potential agent that facilitate tissue recovery and wound repair...
  5. Enhancing Use of Hydroxyurea In Sickle Cell Disease Using Patient Navigators
    Wally R Smith; Fiscal Year: 2013
    ..a clinical endpoint, or maximum dose;ED and hospital visits;mean corpuscular volume;total hemoglobin;white blood cell count;reticulocyte count;and quality of life...
  6. A Microfluidic Bone Marrow Niche for the Study of Hematopoiesis
    Ying Zheng; Fiscal Year: 2013
    ..both healthy and diseased states, but could also revolutionize preclinical testing for therapies to increase blood cell count in diseases where they are low, either because of the disease itself or its therapy...
  7. STAT Palm-Sized Blood Counter
    EUGENE YAN HO CHAN; Fiscal Year: 2010
    ..For instance, a rapidly rising white blood cell count may occur during infections or leukemic blast crises...
  8. STAT Palm-Sized Blood Counter
    EUGENE YAN HO CHAN; Fiscal Year: 2013
    ..For instance, a rapidly rising white blood cell count may occur during infections or a leukemic blast crises...
  9. Proof-of-Concept for Card-Based CD4 Cell Counting
    HAROLD EDWARD AYLIFFE; Fiscal Year: 2010
    ..The integrated system will perform a total white blood cell count, absolute CD4+ T cell count, and percent CD4 count using a new volumetric combination electric impedance/..
  10. ProACT Planning Grant
    DAVID TOM HUANG; Fiscal Year: 2013
    ..has superior performance for detection of bacterial infection compared to traditional markers such as white blood cell count. Initial European trials testing the ability of procalcitonin to improve antibiotic prescription practices ..
  11. SIS multicenter study of duration of antibiotics for intraabdominal infection
    Robert G Sawyer; Fiscal Year: 2011
    ..four days of antibiotic therapy to antibiotic therapy terminated one day after normalization of white blood cell count (= 11,000/ul) and normalization of systemic temperature (<38...
  12. Procalcitonin Antibiotic Consensus Trial (ProACT)
    DAVID TOM HUANG; Fiscal Year: 2013
    ..has superior performance for detection of bacterial infection compared to traditional markers such as white blood cell count. We propose ProACT (Procalcitonin Antibiotic Consensus Trial), a 1514 subject, eight site, randomized trial ..
  13. ENDODONTIC TREATMENT FOR PERSONS WHO ARE HIV POSITIVE
    David Rosenstein; Fiscal Year: 2001
    ..Pretreatment blood samples will be analyzed for CD4 and CD8 cell counts, white blood cell count with differential, p24 antigen level, beta-2 microglobulin level, and erythrocyte sedimentation rate...
  14. A New Preparation and Analysis System for the CBC
    James W Winkelman; Fiscal Year: 2010
    ..provide all the conventional components of the Complete Blood Count (CBC) as well as a differential white blood cell count. An assessment of red blood cell and platelet morphology should also be feasible...
  15. DEVELOPMENT OF AN ULTRASONIC HEMATOCRIT DEVICE
    FRANCIS COREY; Fiscal Year: 1999
    Develop a portable. rugged device that will measure hematocrit, mean corpuscular volume, and red blood cell count within +-2o% through the use of a novel technique based on measuring the ultrasonic energy back scattered from a blood ..
  16. IMMUNE FUNCTION IN CHILDREN
    Sybil Crawford; Fiscal Year: 2000
    ..Assessment of immune function will include determination of total white blood cell count, distribution of T-cells and subsets, B-cells,a nd monocytes, functional analyses of T-cells and B-cells, and ..
  17. GENETIC MODIFIERS OF SEVERITY IN SICKLE CELL ANEMIA
    Orah Platt; Fiscal Year: 2005
    ..this proposal we focus on one of the key risk factors for severity identified by the CSSCD - baseline white blood cell count (baseline WBC)...
  18. A Simple Point Of Care White Blood Cell Count Test
    WAI LAW; Fiscal Year: 2005
    ..In Phase II, we propose to scale-up the device, develop a palm-size reader, thoroughly test the assay system, and prepare for a clinical trial in Phase IIl . ..
  19. A Simple Point Of Care White Blood Cell Count Test
    WAI LAW; Fiscal Year: 2001
    ..We propose developing a simple device that will assay WBC in whole blood and will be as accurate as commercial cell counting instruments. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE ..
  20. A New Preparation and Analysis System for the CBC
    JAMES WINKELMAN; Fiscal Year: 2005
    ..provide all the conventional components of the Complete Blood Count (CBC) as well as a differential white blood cell count. An assessment of red blood cell and platelet morphology should also be feasible...
  21. Phase II SBIR: WHI-07: A Novel Dual-Function Microbicide
    OSMOND D CRUZ; Fiscal Year: 2005
    ....
  22. PHI-443: Novel Non-Spermicidal Anti-HIV Microbicide
    OSMOND D CRUZ; Fiscal Year: 2003
    ..Specific Aims 1 and 2 may provide the foundation for the clinical development of PHI-443 in Phase II studies as a safe, effective broad-spectrum anti-HIV microbicide without conception-inhibiting functions. ..
  23. Vanadocenes as a New Class of Spermicidal Drugs
    OSMOND D CRUZ; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  24. Stampidine: A Novel Broad-Spectrum Anti-HIV Microbicide
    OSMOND D CRUZ; Fiscal Year: 2005
    ..Specific Aims 1 and 2 may provide the foundation for the clinical development of STAMP in Phase II studies as a safe, effective broad-spectrum anti-HIV microbicide without conception-inhibiting functions. ..
  25. NOVEL CONTRACEPTIVES WITH ANTI-HIV ACTIVITY
    OSMOND D CRUZ; Fiscal Year: 2001
    ..The preclinical data on in vivo efficacies of WHI-05 and WHI-07 will be essential to further explore the utility of these novel drugs for clinical studies in human patients. ..
  26. METVAN: A Novel Anticancer Agent
    OSMOND D CRUZ; Fiscal Year: 2003
    ..The knowledge gained from these studies described under Specific Aims 1-2 is expected to facilitate the design of innovative treatment regimens employing METVAN for metastatic breast cancer and brain tumor patients. ..
  27. FLP-102: Rationally Engineered Antiviral Protein
    OSMOND D CRUZ; Fiscal Year: 2003
    ..The preclinical data on FLP-102 will be essential to further explore the utility of this novel recombinant PAP mutant for Phase II. ..
  28. PHI 346: A Novel Dual-Function Microbicide
    OSMOND D CRUZ; Fiscal Year: 2003
    ..Following successful completion of the Phase I in vivo efficacy studies, gel formulation of PHI-346 will be further explored as a vaginal dual-function microbicide in Phase II. ..
  29. CBL FUNCTION IN CELLULAR SIGNALING AND TRANSFORMATION
    Brian Druker; Fiscal Year: 2003
    ..Through these studies the investigators should gain a greater understanding of the contribution of tyrosine phosphorylation of Cbl to its function and the role of Cbl in myeloid transformation. ..
  30. FORMATION AND SURVIVAL OF RED BLOOD CELLS
    Ernest Beutler; Fiscal Year: 2001
    ..Should these point mutations fail to alter gene transcription, a search will be made for other potential mutations in linkage disequilibrium with the known -5,-8 and -24 polymorphisms, by sequencing upstream through the promotor. ..
  31. CHRONIC MYELOGENOUS LEUKEMIA AND BCR-ABL SUBSTRATES
    Brian Druker; Fiscal Year: 2009
    ..Combined, these data should offer significant insights into the biology of and the mechanism of transformation by Bcr-Abl. ..
  32. Levels of Inflammatory Markers in Treatment of Stroke
    Mitchell Elkind; Fiscal Year: 2008
    ..abstract_text> ..
  33. Inflammation and Ovarian Cancer
    Clareann Bunker; Fiscal Year: 2008
    ..In particular, NSAID use may prove to be a potentially important chemopreventative for this often-fatal disease. ..
  34. Inflammatory and Infectious Burden and Risk of Stroke
    Mitchell Elkind; Fiscal Year: 2008
    ..The cross-sectional associations between inflammatory and infectious markers and quantitative MRI abnormalities will also be assessed. ..
  35. A Mouse Model of Gaucher Disease
    Ernest Beutler; Fiscal Year: 2005
    ..In particular, electron microscopy and light microscopy will be used to attempt to demonstrate the development of Gaucher cells in the chimeric mice. ..
  36. Cancer and Kinases
    Brian Druker; Fiscal Year: 2005
    ..By facilitating the development of these drugs, we hope to improve the outcome for patients with cancer as rapidly as possible. ..
  37. Inflammation and Infection as Risk Factors in Stroke
    Mitchell Elkind; Fiscal Year: 2006
    ..pneumoniae) is associated with stroke risk, and that elevated white blood cell count and soluble tumor necrosis factor receptor levels are associated with carotid atherosclerosis...
  38. Iron Status: A Pathway Analysis in Multiple Ethnicities
    Christine McLaren; Fiscal Year: 2009
    ..Potential study results could be used to identify individuals at risk for iron deficiency and to develop innovative prevention and treatment strategies. ..
  39. PATHOGENIC MECHANISMS OF HELICOBACTER PYLORI GASTRITIS
    Ciaran Kelly; Fiscal Year: 2002
    ..Identifying H.pylori virulence factors which modulate host immune and inflammatory responses and determining their mechanisms of action are key to targeting new management strategies for this highly prevalent pathogen. ..
  40. TOBACCO EXPOSURE REDUCTION
    Dorothy Hatsukami; Fiscal Year: 2008
    ..The results of research from this TTURC will provide the scientific basis for urgent policy, public education, and regulatory efforts to reduce tobacco harm. ..
  41. Anti-VEGF in Tumors & Wounds: Efficacy vs Toxicity
    Herbert I Hurwitz; Fiscal Year: 2010
    ..This work has the potential to improve both the safety and efficacy of this novel class of drugs. I;' ..
  42. First Int'l Symposium on Childhood and Adolescent NHL
    Mitchell Cairo; Fiscal Year: 2003
    ..abstract_text> ..
  43. MECHANISMS OF LEUKOCYTE RECRUITMENT IN IBD
    Ciaran Kelly; Fiscal Year: 2005
    ..An in-depth, mechanistic understanding of the regulation of ENA-78 gene expression in human enterocytes may lead to novel therapeutic approaches to IBD. ..
  44. Baltimore VIRAHEP-C Clinical Center
    Charles Howell; Fiscal Year: 2005
    ..These studies may provide important new insights into the pathogenesis of HCV and lead to novel therapies for chronic HCV. ..
  45. NIEMANN-PICK DISEASE
    Melissa Wasserstein; Fiscal Year: 2005
    ..In sum, these studies should provide important diagnostic and therapeutic information to improve the outcome of patients diagnosed with NPD. ..
  46. CYTOKINE CONJUGATES FOR TREATING THROMBOCYTOPENIA
    George Cox; Fiscal Year: 2003
    ..These proteins will find utility in treating thrombocytopenia resulting from cancer chemotherapy. ..
  47. NEW CLINICAL BIOMARKER FOR CANCER--WOUND ANGIOGENESIS
    Herbert Hurwitz; Fiscal Year: 2005
    ..4) To evaluate several potential refinements of this normal wound angiogenesis assay in healthy volunteers, and incorporate these refinements in to patient studies involving novel anti-angiogenesis agents. ..
  48. B CLL Subtypes--Correlation with Clinical Outcome
    Neil Kay; Fiscal Year: 2002
    ....
  49. CYTOKINE MEDIATED DIFFERENTIATION THERAPY
    B Smith; Fiscal Year: 2005
    ..abstract_text> ..
  50. Energy Balance, Organochlorine Exposure, and Possible Toxicologic Effects
    Anneclaire De Roos; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  51. FACSAria Flow Cytometer
    Doris Tse; Fiscal Year: 2007
    ..This information will potentiate the development or improvement of medical procedures towards their prevention and treatment. [unreadable] [unreadable] [unreadable]..
  52. GENE EXPRESSION BY HUMAN GRANULOCYTIC EHRLICHIOSIS AG
    Yasuko Rikihisa; Fiscal Year: 2004
    ..These efforts are expected to reveal an important role for the p44-multigene family in strategies of adaptive surface variation and avoidance of host immune responses. ..
  53. HIV PREVENTION TRIALS UNIT - MALAWI
    Taha Taha; Fiscal Year: 2006
    ..We intend to continue these studies and to expand to additional sites. ..
  54. Engineered Hematopoietic Cell Self-renewal and Death
    Larry Lasky; Fiscal Year: 2006
    ..In addition to marrow replacement, the cells may be usable for the production of other cells and tissues, especially given recent discoveries regarding stem cell plasticity. ..
  55. Epo as a Rescue Agent for Perinatal Hypoxia-Ischemia
    Sandra Juul; Fiscal Year: 2004
    ....
  56. Immune Response to Clostridium difficile
    Ciaran Kelly; Fiscal Year: 2008
    ..These specific aims are designed to advance further our knowledge of the immunobiology of C. difficile toxin-induced diarrhea and the mechanisms of immune protection in humans. [unreadable] [unreadable] [unreadable]..
  57. Biomarkers of Formaldehyde Exposure and Toxicity
    Luoping Zhang; Fiscal Year: 2010
    ..The data produced from these studies will be useful to public health agencies in their evaluation of the leukemia risk presented by formaldehyde. ..
  58. PTHrP on normal osteoblast differentiation and function
    RAMIRO TORIBIO; Fiscal Year: 2008
    ..Dr. Thomas Rosol's laboratory will provide an excellent environment for developing the skills necessary to become a successful independent researcher. ..
  59. Sleep-disordered breathing, sleep stages, and heart rate variability in children
    Duanping Liao; Fiscal Year: 2008
    ..The knowledge gained from this study can potentially improve the management and treatment of childhood SDB. [unreadable] [unreadable] [unreadable] [unreadable]..
  60. Long-Acting IFN-gamma for Treating Ovarian Cancer
    George Cox; Fiscal Year: 2005
    ..Information gained from these studies will aid in creating long-acting versions of other members of this gene family for use in treating cancer, infectious disease and hematopoietic disorders. ..
  61. Assessing Circulating Progenitor Cells in Heart Disease
    Thomas Povsic; Fiscal Year: 2007
    ..This study will look at two methods of measuring these stem cells in the blood of heart patients. These methods may someday be used to predict who will or will not develop heart disease or other complications. ..
  62. METHODS IN COMPLEMENTARY/ALTERNATIVE MEDICINE & HIV/AIDS
    Leanna Standish; Fiscal Year: 2001
    ..The Center is seeking funding to complete analysis of both the AMCOA and Bastyr-Johns Hopkins MACS studies. ..
  63. Embryonic Stem Cell Therapy for Lung Disorders
    Carolyn Lutzko; Fiscal Year: 2004
    ..The overall goal of these studies is to further our understanding of the biology of human embryonic stem cells, and their potential to serve as vehicles for therapeutic cell delivery to the respiratory epithelium. ..
  64. North American Naturopathic Medical Research Consortium
    Leanna Standish; Fiscal Year: 2003
    ..abstract_text> ..
  65. VIRUS PHOTOINACTIVATION--DIMETHYLMETHYLENE BLUE IN RBC
    Stephen Wagner; Fiscal Year: 2004
    ..abstract_text> ..