viral cytopathogenic effect

Summary

Summary: Visible morphologic changes in cells infected with viruses. It includes shutdown of cellular RNA and protein synthesis, cell fusion, release of lysosomal enzymes, changes in cell membrane permeability, diffuse changes in intracellular structures, presence of viral inclusion bodies, and chromosomal aberrations. It excludes malignant transformation, which is CELL TRANSFORMATION, VIRAL. Viral cytopathogenic effects provide a valuable method for identifying and classifying the infecting viruses.

Top Publications

  1. ncbi Differential distribution of non-structural proteins of foot-and-mouth disease virus in BHK-21 cells
    Mercedes García-Briones
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Spain
    Virology 349:409-21. 2006
  2. ncbi Identification of a calmodulin-binding and inhibitory peptide domain in the HIV-1 transmembrane glycoprotein
    M A Miller
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pennsylvania 15261
    AIDS Res Hum Retroviruses 9:1057-66. 1993
  3. pmc Molecular mechanisms of West Nile virus pathogenesis in brain cell
    Wee Lee Koh
    National University of Singapore, Singapore
    Emerg Infect Dis 11:629-32. 2005
  4. ncbi Suppression of Japanese encephalitis virus infection by non-steroidal anti-inflammatory drugs
    Chun Jung Chen
    Department of Education and Research, Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China
    J Gen Virol 83:1897-905. 2002
  5. ncbi In vitro inhibition of Chikungunya and Semliki Forest viruses replication by antiviral compounds: synergistic effect of interferon-alpha and ribavirin combination
    S Briolant
    Département de Biologie des Agents Transmissibles, Centre de Recherches du Service de Sante des Armees, BP 87, 24, av des Maquis du Grésivaudan, 38702 Cedex, La Tronche, France
    Antiviral Res 61:111-7. 2004
  6. ncbi Pathogenesis of avian pneumovirus infection in turkeys
    F F Jirjis
    Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, St Paul 55108, USA
    Vet Pathol 39:300-10. 2002
  7. ncbi A salmonid cell line (TO) for production of infectious salmon anaemia virus (ISAV)
    H I Wergeland
    Department of Fisheries and Marine Biology, University of Bergen, Bergen High Technology Center, Norway
    Dis Aquat Organ 44:183-90. 2001
  8. pmc Inhibition of infectious pancreatic necrosis virus replication by atlantic salmon Mx1 protein
    Rannveig Larsen
    Department of Marine Biotechnology, Norwegian College of Fishery Science, University of Tromsø, N 9037 Tromsø, Norway
    J Virol 78:7938-44. 2004
  9. pmc Longer and shorter forms of Sendai virus C proteins play different roles in modulating the cellular antiviral response
    D Garcin
    Department of Genetics and Microbiology, University of Geneva School of Medicine, CH1211 Geneva, Switzerland
    J Virol 75:6800-7. 2001
  10. pmc Alpha and gamma interferons inhibit herpes simplex virus type 1 infection and spread in epidermal cells after axonal transmission
    Z Mikloska
    Centre for Virus Research, Westmead Millennium Institute, Westmead Hospital and University of Sydney, Westmead, New South Wales 2145, Australia
    J Virol 75:11821-6. 2001

Detail Information

Publications196 found, 100 shown here

  1. ncbi Differential distribution of non-structural proteins of foot-and-mouth disease virus in BHK-21 cells
    Mercedes García-Briones
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Spain
    Virology 349:409-21. 2006
    ..3D(pol) and its precursor 3CD(pol) were also detected in nuclear fractions of infected cells, suggesting that these proteins can directly interact with the nucleus during FMDV infection...
  2. ncbi Identification of a calmodulin-binding and inhibitory peptide domain in the HIV-1 transmembrane glycoprotein
    M A Miller
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pennsylvania 15261
    AIDS Res Hum Retroviruses 9:1057-66. 1993
    ..These results suggest a novel mechanism of viral cytopathogenesis mediated by the interaction of HIV-1 TM protein with cellular CaM, that could lead to an uncoupling of critical cellular signal transduction pathways...
  3. pmc Molecular mechanisms of West Nile virus pathogenesis in brain cell
    Wee Lee Koh
    National University of Singapore, Singapore
    Emerg Infect Dis 11:629-32. 2005
    ..These changes may be useful as potential biomarkers and elucidate novel mechanisms behind the neuropathology of infection with this virus...
  4. ncbi Suppression of Japanese encephalitis virus infection by non-steroidal anti-inflammatory drugs
    Chun Jung Chen
    Department of Education and Research, Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China
    J Gen Virol 83:1897-905. 2002
    ..Our data suggest that the signalling pathways of MAPK play a role in the antiviral action of salicylate...
  5. ncbi In vitro inhibition of Chikungunya and Semliki Forest viruses replication by antiviral compounds: synergistic effect of interferon-alpha and ribavirin combination
    S Briolant
    Département de Biologie des Agents Transmissibles, Centre de Recherches du Service de Sante des Armees, BP 87, 24, av des Maquis du Grésivaudan, 38702 Cedex, La Tronche, France
    Antiviral Res 61:111-7. 2004
    ..Moreover, the combination of IFN-alpha2b and ribavirin had a subsynergistic antiviral effect on these two alphaviruses and should be evaluated for the treatment of these infections...
  6. ncbi Pathogenesis of avian pneumovirus infection in turkeys
    F F Jirjis
    Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, St Paul 55108, USA
    Vet Pathol 39:300-10. 2002
    ..In this experiment, turkey poults inoculated with tissue culture-propagated APV developed clinical signs similar to those seen in field cases associated with infection with this virus...
  7. ncbi A salmonid cell line (TO) for production of infectious salmon anaemia virus (ISAV)
    H I Wergeland
    Department of Fisheries and Marine Biology, University of Bergen, Bergen High Technology Center, Norway
    Dis Aquat Organ 44:183-90. 2001
    ..Salmon injected with diluted virus supernatant showed mortalities, hematocrit values and clinical signs in accordance with infectious salmon anaemia...
  8. pmc Inhibition of infectious pancreatic necrosis virus replication by atlantic salmon Mx1 protein
    Rannveig Larsen
    Department of Marine Biotechnology, Norwegian College of Fishery Science, University of Tromsø, N 9037 Tromsø, Norway
    J Virol 78:7938-44. 2004
    ..Moreover, the list of viruses inhibited by Mx proteins is extended to include double-stranded RNA viruses...
  9. pmc Longer and shorter forms of Sendai virus C proteins play different roles in modulating the cellular antiviral response
    D Garcin
    Department of Genetics and Microbiology, University of Geneva School of Medicine, CH1211 Geneva, Switzerland
    J Virol 75:6800-7. 2001
    ..It is possible that IFN-alpha signaling to induce an anti-VSV state can occur independently of the well-established Jak/Stat/ISGF3 pathway and that it is this parallel pathway that is targeted by the longer C proteins...
  10. pmc Alpha and gamma interferons inhibit herpes simplex virus type 1 infection and spread in epidermal cells after axonal transmission
    Z Mikloska
    Centre for Virus Research, Westmead Millennium Institute, Westmead Hospital and University of Sydney, Westmead, New South Wales 2145, Australia
    J Virol 75:11821-6. 2001
    ..Therefore, both IFN-alpha and -gamma could contribute to the control of HSV-1 spread and shedding in a similar fashion in recurrent herpetic lesions...
  11. ncbi Inhibition of glycogen synthase kinase 3beta suppresses coxsackievirus-induced cytopathic effect and apoptosis via stabilization of beta-catenin
    J Yuan
    Department of Pathology and Laboratory Medicine, The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia St Paul s Hospital, Vancouver, British Columbia, Canada
    Cell Death Differ 12:1097-106. 2005
    ..Taken together, our results demonstrate that CVB3 infection stimulates GSK3beta activity via a tyrosine kinase-dependent mechanism, which contributes to CVB3-induced CPE and apoptosis through dysregulation of beta-catenin...
  12. ncbi Polarized glycoprotein targeting affects the spread of measles virus in vitro and in vivo
    Markus Moll
    Institute of Virology, Philipps University Marburg, Robert Koch str 17, 35037 Marburg, Germany
    J Gen Virol 85:1019-27. 2004
    ..These data strongly suggest that basolateral targeting of MV glycoproteins helps to overcome the epithelial barrier and thereby facilitates the systemic spread of MV infection in vivo...
  13. ncbi Adaptation of canine distemper virus to canine footpad keratinocytes modifies polymerase activity and fusogenicity through amino acid substitutions in the P/V/C and H proteins
    Jean Paul Rivals
    Institut de Biotechnologie, Batiment de Biologie, University of Lausanne, CH 1015 Lausanne, Switzerland
    Virology 359:6-18. 2007
    ....
  14. ncbi Growth of infectious salmon anaemia virus in CHSE-214 cells and evidence for phenotypic differences between virus strains
    F S Kibenge
    Department of Pathology and Microbiology, AVC Inc and Department of Health Management 3, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, PEI, Canada
    J Gen Virol 81:143-50. 2000
    ..5 kDa, respectively. Viral proteins in isolates 'Back Bay 98' and RPC/NB-049 were of similar sizes, except that VP3 was 43 kDa. Taken together, these results show that there are phenotypic differences among strains of ISAV...
  15. pmc Inhibition of human coronavirus NL63 infection at early stages of the replication cycle
    Krzysztof Pyrc
    Department of Human Retrovirology, University of Amsterdam, The Netherlands
    Antimicrob Agents Chemother 50:2000-8. 2006
    ..These agents may be investigated further for the treatment of coronavirus infections...
  16. ncbi The vaccinia virus kelch-like protein C2L affects calcium-independent adhesion to the extracellular matrix and inflammation in a murine intradermal model
    Marta Pires de Miranda
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    J Gen Virol 84:2459-71. 2003
    ..In summary, we found that C2L is not required for virus replication in vitro but contributes to aspects of VV-induced CPE and reduces immunopathology in vivo...
  17. ncbi Combining high selectivity of replication with fiber chimerism for effective adenoviral oncolysis of CAR-negative melanoma cells
    A A Rivera
    Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
    Gene Ther 11:1694-702. 2004
    ....
  18. ncbi A new picornavirus isolated from bank voles (Clethrionomys glareolus)
    B Niklasson
    Swedish Institute for Infectious Disease Control, Solna, S 171 82, Sweden
    Virology 255:86-93. 1999
    ..A partial 5' noncoding region sequence of Ljungan virus showed the highest degree of relatedness to cardioviruses. Two additional isolates were serologically and molecularly related to the prototype...
  19. ncbi CD26 expression correlates with entry, replication and cytopathicity of monocytotropic HIV-1 strains in a T-cell line
    T Oravecz
    Division of Hematologic Products, Food and Drug Administration, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Med 1:919-26. 1995
    ..This study identifies CD26 as a key marker for M-tropic human immunodeficiency virus type 1 (HIV-1) infection and suggests a mechanism for the early loss of CD26-expressing cells in HIV-1-infected individuals...
  20. ncbi Laboratory efforts to cultivate noroviruses
    Erwin Duizer
    National Institutes for Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands
    J Gen Virol 85:79-87. 2004
    ..Thus, attempts to develop a method for the cultivation of NoV were unsuccessful...
  21. ncbi In vitro characterization and preferential infection by canine distemper virus of glial precursors with Schwann cell characteristics from adult canine brain
    E A Orlando
    Department of Pathology, University of Veterinary Medicine Hannover, Hannover, Germany
    Neuropathol Appl Neurobiol 34:621-37. 2008
    ..The aim of this study was to establish primary glial cell cultures from adult canine brain for the analysis of CDV spread and cell tropism...
  22. ncbi An oncolytic adenovirus selective for retinoblastoma tumor suppressor protein pathway-defective tumors: dependence on E1A, the E2F-1 promoter, and viral replication for selectivity and efficacy
    John L Jakubczak
    Genetic Therapy, Inc, Gaithersburg, Maryland 20878, USA
    Cancer Res 63:1490-9. 2003
    ..Our results support the use of oncolytic adenoviruses using tumor-selective promoter(s) that are activated or derepressed in tumor cells by virtue of a particular defective pathway, such as the Rb pathway...
  23. ncbi Heat shock phenocopies E1B-55K late functions and selectively sensitizes refractory tumor cells to ONYX-015 oncolytic viral therapy
    Clodagh C O'Shea
    Cancer Research Institute, University of California, San Francisco, CA 94115, USA
    Cancer Cell 8:61-74. 2005
    ..Moreover, these data suggest that the concomitant induction of a heat shock response could significantly improve ONYX-015 cancer therapy...
  24. pmc Beta interferon and gamma interferon synergize to block viral DNA and virion synthesis in herpes simplex virus-infected cells
    Amy T Pierce
    Department of Microbiology and Immunology, Tulane University Medical School, New Orleans, LA 70112, USA
    J Gen Virol 86:2421-32. 2005
    ..It was inferred that IFN-mediated suppression of HSV-1 replication may be a central mechanism by which the host immune system limits the spread of HSV-1 infection in vivo...
  25. ncbi Identification of cell lines permissive for human coronavirus NL63
    Oliver Schildgen
    University of Bonn, Institute for Medical Microbiology, Immunology, and Parasitology, Department of Virology, and Children s Hospital, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    J Virol Methods 138:207-10. 2006
    ....
  26. pmc Changes in rhinovirus protein 2C allow efficient replication in mouse cells
    Julie R Harris
    Department of Microbiology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Virol 77:4773-80. 2003
    ..The characterization of a rhinovirus host range mutant will facilitate the investigation of cellular proteins required for efficient viral growth and the development of a murine model for rhinovirus infection...
  27. ncbi New insights on the neuropathology of West Nile virus
    Pierre Emmanuel Ceccaldi
    Rabies Unit, Virology Department, Pasteur Institute, Paris, France
    FEMS Microbiol Lett 233:1-6. 2004
    ..In murine neural cell cultures, the selective infection of neurons was accompanied by physiopathological changes and a cytopathic effect, showing the direct effect of infection of neurons as one of the causes of WNV neuropathogenicity...
  28. ncbi Ras-dependent oncolysis with an adenovirus VAI mutant
    Manel Cascallo
    Translational Research Laboratory, Institut Catala d Oncologia, 08907, L Hospitalet, Barcelona, Spain
    Cancer Res 63:5544-50. 2003
    ..We demonstrate here that a VAI RNA mutant presents a Ras-dependent replication and can be used for oncolytic virotherapy of pancreatic tumors...
  29. ncbi The ultrastructure of the developing replication site in foot-and-mouth disease virus-infected BHK-38 cells
    Paul Monaghan
    Institute for Animal Health, Ash Road, Pirbright, Woking, Surrey GU24 0NF, UK
    J Gen Virol 85:933-46. 2004
    ..With conventional fixation, FMDV particles were not seen; however, following high-pressure freezing and freeze-substitution, many clusters of virus-like particles were seen...
  30. pmc Constitutive expression of Atlantic salmon Mx1 protein in CHSE-214 cells confers resistance to infectious salmon anaemia virus
    Molly J T Kibenge
    Department of Pathology and Microbiology, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, PE C1A 4P3, Canada
    Virol J 2:75. 2005
    ....
  31. pmc Tubulointerstitial nephritis due to a mutant polyomavirus BK virus strain, BKV(Cin), causing end-stage renal disease
    R D Smith
    Department of Pathology, University of Cincinnati, Ohio 45267 0529, USA
    J Clin Microbiol 36:1660-5. 1998
    ..It is suggested that the mutation and a coding region rearrangement of this strain of BKV designated BKV(Cin) has the potential to alter viral DNA replication and enhance pathogenicity...
  32. ncbi Human immunodeficiency virus type 1 VPU protein affects Sindbis virus glycoprotein processing and enhances membrane permeabilization
    M E Gonzalez
    Centro de Biologia Molecular CSIC UAM, Universidad Autonoma de Madrid, Madrid, Cantoblanco, 28049, Spain
    Virology 279:201-9. 2001
    ..Taken together, our data support the notion that HIV-1 Vpu and SV 6K proteins share some analogous functions...
  33. ncbi Isolation and identification of infectious salmon anaemia virus (ISAV) from Coho salmon in Chile
    F S Kibenge
    Department of Pathology and Microbiology, University of Prince Edward Island, Charlottetown, Canada
    Dis Aquat Organ 45:9-18. 2001
    ..This outbreak, which produced high mortality in Coho salmon due to ISAV, is unique and may represent the introduction of the virus to a native wild fish population or a new strain of ISAV...
  34. pmc Infection of cultured human and monkey cell lines with extract of penaeid shrimp infected with Taura syndrome virus
    Josefina Audelo-del-Valle
    Universidad de Occidente, Los Mochis, Sinaloa, Mexico
    Emerg Infect Dis 9:265-6. 2003
    ..Here we demonstrate that TSV also infects human cell lines, which may suggest that Penaeus is a potential reservoir of this virus...
  35. ncbi Vaccinia virus kelch protein A55 is a 64 kDa intracellular factor that affects virus-induced cytopathic effect and the outcome of infection in a murine intradermal model
    Philippa M Beard
    Department of Virology, Faculty of Medicine, Imperial College London, St Mary s Campus, Norfolk Place, London W2 1PG, UK
    J Gen Virol 87:1521-9. 2006
    ..In a murine intradermal model of VACV infection, a virus lacking the A55R gene induced larger lesions than wild-type and revertant control viruses...
  36. ncbi New oncolytic adenoviruses with hypoxia- and estrogen receptor-regulated replication
    Ruben Hernandez-Alcoceba
    Department of Internal Medicine, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI 48109, USA
    Hum Gene Ther 13:1737-50. 2002
    ..These data indicate that the simultaneous regulation of E1A and E4 viral transcription units by the appropriate combination of promoters can increase the tumor selectivity of oncolytic adenoviruses...
  37. ncbi The envelope gene is a cytopathic determinant of CCR5 tropic HIV-1
    Kevin Olivieri
    Department of Microbiology and Myles H Thaler Center for AIDS and Human Retrovirus Research, University of Virginia, Charlottesville, VA 22908, USA
    Virology 358:23-38. 2007
    ..We conclude that the enhanced thymic replication and CPE shown by the R5-AIDS clone is due to enhanced efficiency of Env-mediated entry via CCR5...
  38. ncbi A-549 is a suitable cell line for primary isolation of coxsackie B viruses
    J R Otero
    Clinical Virology Unit, Microbiology Department, Hospital 12 de Octubre, Avda de Cordoba s n, 28041 Madrid, Spain
    J Med Virol 65:534-6. 2001
    ..In conclusion, growth in A-549 but not MRC-5 cells identified coxsackie B viruses in most cases. A-549 was comparable to BGM for primary isolation of coxsackie B viruses...
  39. ncbi Effects of the Ad5 upstream E1 region and gene products on heterologous promoters
    Dennis Hoffmann
    Ruhr Universitat Bochum, Abteilung für Molekulare und Medizinische Virologie, Bldg MA, Rm 6 40, D 44801 Bochum, Germany
    J Gene Med 7:1356-66. 2005
    ..Using different reporter genes, some previous studies demonstrated the maintenance of heterologous promoter specificity in the adenoviral context, while others reported that adenoviral sequences interfere with promoter activity...
  40. ncbi Biological properties of chimeric West Nile viruses
    Victoria Borisevich
    Department of Molecular Biosciences, University of Kansas, 1200 Sunnyside Ave, Lawrence, KS 66045, USA
    Virology 349:371-81. 2006
    ..Chimeric viruses carrying the NY99 structural proteins were attenuated in neuroinvasiveness and demonstrated an immunogenicity superior to W956...
  41. ncbi Interference of porcine reproductive and respiratory syndrome virus replication on MARC-145 cells using DNA-based short interfering RNAs
    Yun Xia He
    National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 427 Maduan Street, Harbin 150001, PR China
    Antiviral Res 74:83-91. 2007
    ..The results presented here indicated that DNA-based siRNA could effectively inhibit the replication of PRRS virus (approximately 681-fold reduction of viral titers) on MARC-145 cells...
  42. ncbi Enhancement of the infectivity of SARS-CoV in BALB/c mice by IMP dehydrogenase inhibitors, including ribavirin
    Dale L Barnard
    Institute for Antiviral Research, Utah State University, Logan, 84322 5600, USA
    Antiviral Res 71:53-63. 2006
    ..Our data do not support the use of ribavirin or other IMP dehydrogenase inhibitors for treating SARS infections in humans...
  43. ncbi Antiviral activity of oligomerization-deficient Stat1
    Uwe Vinkemeier
    Leibniz Forschungsinstitut fur Molekulare Pharmakologie, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Genome Inform 16:44-8. 2005
    ..Moreover, the concentration of activated Stat1 in the nucleus may generally play a critical role for interferon-induced target gene activation...
  44. pmc Interferon-beta 1a and SARS coronavirus replication
    Lisa E Hensley
    Virology Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702, USA
    Emerg Infect Dis 10:317-9. 2004
    ..Here, we report that recombinant human interferon-beta 1a potently inhibits SARS coronavirus replication in vitro...
  45. ncbi Coumarins and pyranocoumarins, potential novel pharmacophores for inhibition of measles virus replication
    Dale L Barnard
    Institute for Antiviral Research, Utah State University, Logan, USA
    Antivir Chem Chemother 13:39-59. 2002
    ..This and related compounds may be valuable leads in the development of a potent and selective class of MV inhibitors that could be used in future in the clinic...
  46. pmc Effects of interferon, ribavirin, and iminosugar derivatives on cells persistently infected with noncytopathic bovine viral diarrhea virus
    David Durantel
    Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom
    Antimicrob Agents Chemother 48:497-504. 2004
    ..Long-alkyl-chain deoxygalactonojirimycin derivatives, which do not inhibit ER alpha-glucosidases, were less potent but still more effective in this system than IFN-alpha or ribavirin...
  47. ncbi Xiao chai hu tang inhibits CVB1 virus infection of CCFS-1 cells through the induction of Type I interferon expression
    Pei Wen Cheng
    Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, No 100, Shin Chuan 1st Road, Kaohsiung 807, Taiwan
    Int Immunopharmacol 6:1003-12. 2006
    ..It interfered the early stage of viral replication (prophylactic effect) and viral replication after infection (therapeutic effect) through the induction of Type I interferon expression...
  48. pmc The synergistic effect of IFN-alpha and IFN-gamma against HSV-2 replication in Vero cells is not interfered by the plant antiviral 1-cinnamoyl-3, 11-dihydroxymeliacarpin
    Erina Petrera
    Laboratory of Virology, Department of Biochemistry, School of Science, University of Buenos Aires, Buenos Aires, Argentina
    Virol J 3:45. 2006
    ..For this purpose we studied the effect of the compound 1-cinnamoyl-3,11-dihydroxymeliacarpin (CDM), which is the responsible for meliacine antiviral action, on the HSV-2 inhibition exerted by IFN alpha, IFN-gamma or their combination...
  49. pmc In vitro activity of expanded-spectrum pyridazinyl oxime ethers related to pirodavir: novel capsid-binding inhibitors with potent antipicornavirus activity
    D L Barnard
    Institute for Antiviral Research, Utah State University, Logan, Utah 84322 5600, USA
    Antimicrob Agents Chemother 48:1766-72. 2004
    ..Both compounds were relatively nontoxic in actively growing cells (50% cytotoxic doses, >/=4,588 nM). These data suggest that these oxime ethers warrant further investigation as potential agents for treating selected PV infections...
  50. pmc Inhibition of multiple subtypes of influenza A virus in cell cultures with morpholino oligomers
    Qing Ge
    AVI BioPharma Inc, 4575 SW Research Way, Corvallis, OR 97333, USA
    Antimicrob Agents Chemother 50:3724-33. 2006
    ..High efficacy by two of the P-PMO against multiple FLUAV subtypes suggests that these oligomers represent a broad-spectrum therapeutic approach against a high percentage of known FLUAV strains...
  51. ncbi Non-structural protein 4A of Hepatitis C virus accumulates on mitochondria and renders the cells prone to undergoing mitochondria-mediated apoptosis
    Yuki Nomura-Takigawa
    Division of Microbiology, Kobe University Graduate School of Medicine, Chuo Ku, Kobe 650 0017, Japan
    J Gen Virol 87:1935-45. 2006
    ..Taken together, these results suggest the possibility that HCV exerts cytopathic effect (CPE) on the infected cells under certain conditions and that NS4A is responsible, at least in part, for the conditional CPE in HCV-infected cells...
  52. ncbi Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity
    Clodagh C O'Shea
    UCSF Comprehensive Cancer Center, San Francisco, CA 94115, USA
    Cancer Cell 6:611-23. 2004
    ..These data reveal that tumor cells have altered mechanisms for RNA export and resolve the controversial role of p53 in governing ONYX-015 oncolytic selectivity...
  53. pmc Potent and long-acting dimeric inhibitors of influenza virus neuraminidase are effective at a once-weekly dosing regimen
    Simon J F Macdonald
    GlaxoSmithKline Medicines Research Centre, Stevenage, United Kingdom
    Antimicrob Agents Chemother 48:4542-9. 2004
    ....
  54. ncbi Effects of interferon-alpha on cytopathic changes and titers for feline herpesvirus-1 in primary cultures of feline corneal epithelial cells
    Lynne S Sandmeyer
    Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON, N1G 2W1, Canada
    Am J Vet Res 66:210-6. 2005
    ..To assess the effect of interferon (IFN)-alpha on viability of feline corneal epithelial cells, replication of feline herpesvirus (FHV)-1, and virus-induced cytopathic changes...
  55. pmc Temporal modulation of an autoprotease is crucial for replication and pathogenicity of an RNA virus
    T Lackner
    Institut für Virologie FB Veterinärmedizin, Justus Liebig Universitat Giessen, Frankfurter Strasse 107, 35392 Giessen, Germany
    J Virol 78:10765-75. 2004
    ..The biotype-specific modulation of NS2-3 autoprocessing indicates a crucial role of the NS2 autoprotease in the pathogenicity of BVDV...
  56. ncbi Potent inhibition of SARS-associated coronavirus (SCOV) infection and replication by type I interferons (IFN-alpha/beta) but not by type II interferon (IFN-gamma)
    Bojian Zheng
    Department of Microbiology, The University of Hong Kong, Pokfulam, Hong Kong
    J Interferon Cytokine Res 24:388-90. 2004
    ..The type I IFN receptor signaling pathway in host cells is mainly involved in the inhibition of SCoV infection and replication. Type I IFNs could be used as potential agents for anti-SARS treatment...
  57. ncbi A fungal tRNA of Aspergillus niger induces IFN-beta synthesis in HEp-2 cells
    Noé Alvarado-Vásquez
    Departamento de Bioquímica Instituto Nacional de Enfermedades Respiratorias Calz de Tlalpan 4502, Col Seccion XVI, C P 14080, Mexico
    Life Sci 77:578-88. 2005
    ..Our results suggest that F-tRNA protected HEp-2 cells against AdV-6 infection, due to its capacity to induce IFN-beta synthesis...
  58. ncbi Prophylactic and therapeutic effects of small interfering RNA targeting SARS-coronavirus
    Bo Jian Zheng
    Department of Microbiology, Institute of Molecular Biology, Department of Pathology, University of Hong Kong, Hong Kong, China
    Antivir Ther 9:365-74. 2004
    ..This in vitro study will serve as the foundation for development of novel anti-SARS therapeutics...
  59. ncbi Characterization of homologous defective interfering RNA during persistent infection of Vero cells with Japanese encephalitis virus
    Sung Wook Yoon
    Department of Biology and Research Institute of Basic Sciences, Kyung Hee University, Seoul 130 701, Korea
    Mol Cells 21:112-20. 2006
    ..Taken together, these ob-servations suggest that the generation of homologous DI RNA during successive JEV acute infections in Vero cells probably participates actively in persistent JEV infection...
  60. pmc Inhibition of severe acute respiratory syndrome virus replication by small interfering RNAs in mammalian cells
    Zhi Wang
    Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China
    J Virol 78:7523-7. 2004
    ..These two plasmids also inhibited viral replication as shown by titer assays and by an examination of viral RNA and protein levels. Thus, our results demonstrated the feasibility of developing siRNAs as effective anti-SARS drugs...
  61. pmc Characterization of an in vitro model of alphavirus infection of immature and mature neurons
    Patty S Vernon
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe St, Baltimore, MD 21205, USA
    J Virol 79:3438-47. 2005
    ..1 cell line is a convenient model system for investigating the interactions of alphaviruses with neurons at various stages of differentiation...
  62. ncbi In vitro antiviral activity of plant extracts on goatpox virus replication
    V Bhanuprakash
    Division of Virology, Indian Veterinary Research Institute, Mukteswar 263 138, India
    Indian J Exp Biol 46:120-7. 2008
    ..Results indicated that the extract of Acacia arabica and Eugenia jambolana leaves inhibited GTPV replication in vitro...
  63. ncbi Inhibition of HIV-1 IIIB and clinical isolates by human parotid, submandibular, sublingual and palatine saliva
    Jan G M Bolscher
    Department of Dental Basic Sciences, Academic Center for Dentistry Amsterdam, The Netherlands
    Eur J Oral Sci 110:149-56. 2002
    ..In conclusion, saliva inhibits HIV-1-infection by the action of high molecular weight components in combination with low molecular weight components from serous as well as mucous saliva, affecting different stages of the infection cycle...
  64. ncbi Antiviral activity of diverse classes of broad-acting agents and natural compounds in HHV-6-infected lymphoblasts
    Lieve Naesens
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    J Clin Virol 37:S69-75. 2006
    ..HHV-6 replication requires complex and poorly understood interactions between viral and cellular factors...
  65. ncbi Antipoliovirus flavonoids from Psiadia dentata
    V Robin
    UPRES, , , Rennes, France
    Antivir Chem Chemother 12:283-91. 2001
    ....
  66. ncbi Recombinant swine beta interferon protects swine alveolar macrophages and MARC-145 cells from infection with Porcine reproductive and respiratory syndrome virus
    C Overend
    Department of Pathobiology and Veterinary Science, University of Connecticut, 61 North Eagleville Road, Storrs, CT, USA
    J Gen Virol 88:925-31. 2007
    ..The data demonstrate that swIFN-beta protects both MARC-145 cells and PAMs from PRRSV infection...
  67. ncbi Apoptosis in cultured human fetal membrane cells infected with influenza virus
    Noboru Uchide
    Department of Biochemistry, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Japan
    Biol Pharm Bull 25:109-14. 2002
    ..We further observed that influenza virus replication is associated with the induction of apoptosis...
  68. pmc Different pH requirements are associated with divergent inhibitory effects of chloroquine on human and avian influenza A viruses
    Livia Di Trani
    Dept of Food and Animal Health, Istituto Superiore di Sanita, Rome, Italy
    Virol J 4:39. 2007
    ..Overall, the present study highlights the critical importance of a host cell factor such as intravesicular pH in determining the anti-influenza activity of chloroquine and other lysosomotropic agents...
  69. ncbi Characterization of inhibitory action of concanamycins against herpes simplex virus
    K Hayashi
    Department of Virology, Toyama Medical and Pharmaceutical University, Japan
    Antivir Chem Chemother 12:51-9. 2001
    ....
  70. ncbi Comparative study of enterovirus 71 infection of human cell lines
    Yu Ye Wen
    Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    J Med Virol 70:109-18. 2003
    ....
  71. ncbi Recovery of infectious Ebola virus from complementary DNA: RNA editing of the GP gene and viral cytotoxicity
    V E Volchkov
    Institut fur Virologie, Philipps Universitat, Robert Koch Strasse 17, 35037 Marburg, Germany
    Science 291:1965-9. 2001
    ..The mutant was significantly more cytotoxic than wild-type virus, indicating that cytotoxicity caused by GP is down-regulated by the virus through transcriptional RNA editing and expression of sGP...
  72. ncbi Inhibition of human cytomegalovirus replication in a human retinal epithelial cell model by antisense oligonucleotides
    B Detrick
    The Department of Pathology, The Johns Hopkins Medical Institutes, Baltimore, Maryland, USA
    Invest Ophthalmol Vis Sci 42:163-9. 2001
    ..The enhanced potency of these oligonucleotides in HRPE cells may be associated with a delay in viral gene transcription and slow viral replication and spread in these cells...
  73. ncbi Universal and mutation-resistant anti-enteroviral activity: potency of small interfering RNA complementary to the conserved cis-acting replication element within the enterovirus coding region
    Hui Sun Lee
    Department of Microbiology, University of Ulsan College of Medicine, Seoul, Korea
    J Gen Virol 88:2003-12. 2007
    ..The same strategy can be successfully applied to the development of siRNA with consistent antiviral effects in other virus groups possessing similar RNA elements...
  74. pmc RSV604, a novel inhibitor of respiratory syncytial virus replication
    Joanna Chapman
    Arrow Therapeutics Ltd, Britannia House, 7 Trinity Street, London SE1 1DB, United Kingdom
    Antimicrob Agents Chemother 51:3346-53. 2007
    ..RSV604, which is currently in phase II clinical trials, represents the first in a new class of RSV inhibitors and may have significant potential for the effective treatment of RSV disease...
  75. ncbi Replication of Ljungan virus in cell culture: the genomic 5'-end, infectious cDNA clones and host cell response to viral infections
    Jens Ola Ekström
    Department of Chemistry and Biomedical Sciences, University of Kalmar, SE 391 82 Kalmar, Sweden
    Virus Res 130:129-39. 2007
    ..IF staining of both prototype 87-012 and the CPE causing 87-012G showed groups of 5-25 infected cells at 48h p.i., suggesting a, for picornaviruses, not previously described direct cell-to-cell transmission...
  76. ncbi Susceptibility of Autographa californica multiple nucleopolyhedrovirus to inhibitors of DNA replication
    David K Thumbi
    Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ont N1G 2W1, Canada
    J Virol Methods 146:209-17. 2007
    ..Taken together, both spectrofluorimetric and qPCR assays are suitable and rapid quantitative approaches to investigate inhibitors of baculovirus DNA replication in infected cells...
  77. ncbi Anti-rhinovirus-specific activity of the alpha-sympathomimetic oxymetazoline
    Stephan Koelsch
    Merck Selbstmedikation GmbH, Darmstadt, Germany
    Arzneimittelforschung 57:475-82. 2007
    ..Therefore, OMZ does not only reduce rhinitis symptoms but additionally offers a causal therapeutic approach...
  78. ncbi Establishment and use of a cell line expressing HSV-1 thymidine kinase to characterize viral thymidine kinase-dependent drug-resistance
    Jee Hyun Kim
    Pharmaceutical Screening Center, Korea Research Institute of Chemical Technology, Taejon 305 600, South Korea
    Antiviral Res 54:163-74. 2002
    ..This HSV-1 TK gene-transfected cell model is a useful tool to rapidly determine HSV-1 drug resistance at the viral TK level...
  79. ncbi Identification of active antiviral compounds against a New York isolate of West Nile virus
    John D Morrey
    Department of Animal, Dairy, and Veterinary Sciences, Institute for Antiviral Research, Utah State University, Logan, UT 84322 4700, USA
    Antiviral Res 55:107-16. 2002
    ....
  80. ncbi [Structure and antiviral activity of adamantane-containing polymer preparation]
    K N Kozeletskaia
    Vopr Virusol 48:19-26. 2003
    ..The efficiency of the antiviral effect depends on a drug's molecular weight and a structure of chemical bonds between the adamantane nucleus and the polymeric matrix...
  81. pmc Changes in mumps virus gene sequence associated with variability in neurovirulent phenotype
    Steven A Rubin
    DVP Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Virol 77:11616-24. 2003
    ..The potential role of these amino acid changes in neurotropism, neurovirulence, and neuroattenuation is discussed...
  82. ncbi Cell culture replication of herpes simplex virus and, or human cytomegalovirus is inhibited by 3,7-dialkoxylated, 1-hydroxyacridone derivatives
    C T Lowden
    Division of Medicinal Chemistry and Natural Products, School of Pharmacy, CB 7630, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Antiviral Res 59:143-54. 2003
    ..As a group, the active 3,7-dialkoxylated compounds likely have diverse mechanisms of action, consequently they are of potential medicinal interest...
  83. pmc Antiviral activity of limitin against encephalomyocarditis virus, herpes simplex virus, and mouse hepatitis virus: diverse requirements by limitin and alpha interferon for interferon regulatory factor 1
    Shin ichiro Kawamoto
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka 565 0871, Japan
    J Virol 77:9622-31. 2003
    ..The unique signals and the fewer properties of myelosuppression suggest that a human homolog of limitin may be used as a new antiviral drug...
  84. ncbi Bupleurum kaoi inhibits Coxsackie B virus type 1 infection of CCFS-1 cells by induction of type I interferons expression
    Pei Wen Cheng
    Graduate Institute of Natural Products, Kaohsiung Medical University, 100 Shih Chuan 1st Road, Kaohsiung 807, Taiwan
    Food Chem Toxicol 45:24-31. 2007
    ..In conclusion, BK possessed antiviral activity against CVB1 infection. It interfered the early stage of viral replication and viral replication after infection through the induction of type I interferon expression...
  85. ncbi Evaluation of immunomodulators, interferons and known in vitro SARS-coV inhibitors for inhibition of SARS-coV replication in BALB/c mice
    Dale L Barnard
    Institute for Antiviral Research, Utah State University, Logan, UT, USA
    Antivir Chem Chemother 17:275-84. 2006
    ..In summary, the data suggest that induction of IFN by mismatched dsRNA or actual treatment with exogenous IFN-alpha can inhibit SARS-CoV replication in the lungs of mice...
  86. ncbi Cyanovirin-N binds to the viral surface glycoprotein, GP1,2 and inhibits infectivity of Ebola virus
    Laura G Barrientos
    Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
    Antiviral Res 58:47-56. 2003
    ..Overall, these studies broaden the range of viruses known to be inhibited by CV-N, and further implicate carbohydrate moieties on viral surface proteins as common viral molecular targets for this novel protein...
  87. ncbi Inhibition of UL54 and UL97 genes of human cytomegalovirus by RNA interference
    M C Shin
    Department of Microbiology, College of Medicine, Catholic Hemopoietic Stem Cell Transplantation Center, The Catholic University of Korea, Seoul 137 701, South Korea
    Acta Virol 50:263-8. 2006
    ..These results demonstrate the effectiveness of siRNAs against experimental HCMV infection and indicate their therapeutic potential...
  88. ncbi Antiviral activity of Spirulina maxima against herpes simplex virus type 2
    Armida Hernández-Corona
    Departamento de Microbiologi a, Escuela Nacional de Ciencias Biologicas, IPN, Carpio y Plan de Ayala S N Casco de Santo Tomás, Apartado Postal 102, Mexico, DF 11340, Mexico
    Antiviral Res 56:279-85. 2002
    ..The highest antiviral activity was detected in the methanol-water 3:1, which suggests that the antiviral activity is probably due to highly polar compounds...
  89. ncbi Influenza virus variants with reduced susceptibility to inhibition by a polyphenol extract from Geranium sanguineum L
    J Serkedjieva
    Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria
    Pharmazie 58:53-7. 2003
    ..Virus-specific protein synthesis in CEF cells infected with the resistant variants, determined by 35S-labelling and following SDS-PAGE, was also less sensitive to inhibition with PC...
  90. pmc Cleavage at the furin consensus sequence RAR/KR(109) and presence of the intervening peptide of the respiratory syncytial virus fusion protein are dispensable for virus replication in cell culture
    Gert Zimmer
    Institut fur Virologie, Tierarztliche Hochschule Hannover, D 30559 Hannover, Germany
    J Virol 76:9218-24. 2002
    ..A deletion mutant containing FCS-1 but lacking FCS-2 and most of pep27 replicated in cell culture as efficiently as the parental virus, indicating that this domain of the F protein is not essential for virus maturation and infectivity...
  91. ncbi [Effect of interferon inductors on infection induced by hepatitis C virus and activity of mRNA cytokines in cell cultures SW-13 and MT-4]
    A N Narovlianskiĭ
    Vopr Virusol 47:17-21. 2002
    ..It was suggested that induction of IFN-gamma, IL-4 and IL-8 plays a certain role in HCV reproduction suppression. The results of this work provide an opportunity for more efficacious use of IFN inducers in therapy of HCV infection...
  92. ncbi Synthesis, cytotoxicity and antiviral activity of N,N'-bis-5-nitropyrimidyl derivatives of dispirotripiperazine
    M Schmidtke
    Institute of Virology, Friedrich Schiller University of Jena, Winzerlaer Street 10, D 07745, Jena, Germany
    Antiviral Res 55:117-27. 2002
    ..Introduction of a methyl group in position 2 of the pyrimidine had no influence on cytotoxicity or antiviral activity...
  93. ncbi Inhibition of the enteroviruses that cause acute hemorrhagic conjunctivitis (AHC) by benzimidazoles; enviroxime (LY 122772) and enviradone (LY 127123)
    M P Langford
    Department of Ophthalmology, Louisiana State University Medical Center, Shreveport 71130 3932, USA
    Antiviral Res 27:355-65. 1995
    ..acutely infected with EV70 or CA24v inhibited virus production (> 2 log10 reduction) and 100% of the viral cytopathogenic effect (CPE)...
  94. ncbi The role of interferon regulatory factors in the cardiac response to viral infection
    Barbara Sherry
    Department of Microbiology, Pathology and Parasitology, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA
    Viral Immunol 15:17-28. 2002
    ..Cardiac tissue damage varies between reovirus strains, and is caused by a direct viral cytopathogenic effect. One determinant of virus-induced cardiac tissue damage is the cardiac interferon-beta (IFN-beta) ..
  95. ncbi Contamination of genetically engineered CHO-cells by epizootic haemorrhagic disease virus (EHDV)
    H Rabenau
    University Clinics of Frankfurt Main, Institute of Medical Virology, Germany
    Biologicals 21:207-14. 1993
    ..Potential sources of the contaminating virus and feasible procedures to avoid adventitous virus infections in cell cultures are discussed...
  96. ncbi Transmissible enteritis of turkeys: experimental inoculation studies with tissue-culture-adapted turkey and bovine coronaviruses
    S Dea
    Centre de Recherche en Virologie, Universite du Quebec, Laval, Canada
    Avian Dis 35:767-77. 1991
    ....
  97. ncbi Buthionine sulfoximine inhibits cytopathic effect and apoptosis induced by infection with human echovirus 9
    T Mikami
    Department of Bacteriology, Hirosaki University School of Medicine, Hirosaki Aomori, Japan
    Arch Virol 149:1117-28. 2004
    ..This finding suggests that enteroviral infections cause apoptosis through the activation of a common pathway that can be inhibited by BSO...
  98. pmc Immunogenicity of cytopathic and noncytopathic viral vectors
    Gabriela Plesa
    Thomas Jefferson University, Kimmel Cancer Center, 233 S 10th Street, BLSB 730, Philadelphia, PA 19107, USA
    J Virol 80:6259-66. 2006
    ..Such compensatory mechanisms may be in place to ensure comparable immunologic memories to various pathogens...
  99. pmc The human membrane cofactor CD46 is a receptor for species B adenovirus serotype 3
    Dominique Sirena
    Institute of Molecular Biology, University of Zurich, CH 8057 Zurich, Switzerland
    J Virol 78:4454-62. 2004
    ..These results have implications for understanding viral pathogenesis and therapeutic gene delivery...
  100. ncbi Identification of phenanthroindolizines and phenanthroquinolizidines as novel potent anti-coronaviral agents for porcine enteropathogenic coronavirus transmissible gastroenteritis virus and human severe acute respiratory syndrome coronavirus
    Cheng Wei Yang
    Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli, Taiwan, ROC
    Antiviral Res 88:160-8. 2010
    ..7%) in rats. Thus, our results suggest that tylophorine compounds are novel and potent anti-coronavirus agents that may be developed into therapeutic agents for treating TGEV or SARS CoV infection...
  101. ncbi Inhibition of feline (FIPV) and human (SARS) coronavirus by semisynthetic derivatives of glycopeptide antibiotics
    Jan Balzarini
    Rega Institute for Medical Research, K U Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    Antiviral Res 72:20-33. 2006
    ..Some compounds showed inhibitory activity against both, whereas other compounds proved inhibitory to either, FIPV or SARS-CoV. There was no close correlation between the EC(50) values of the glycopeptide derivatives for FIPV or SARS-CoV...

Research Grants31

  1. ANTI-VIRAL TREATMENT OF DEVELOPING BOVINE EMBRYOS
    Maurice Givens; Fiscal Year: 2002
    ....
  2. CELLULAR IMMUNE RESPONSE IN CHRONIC HEPATITIS C
    David Nelson; Fiscal Year: 2003
    ..These studies will provide insight into basic immunologic principles associated with the host's immune response to this viral infection, as well as provide the basis for new interventional strategies. ..
  3. Mechanisms of Innate and Adaptive Immunity In HCV
    David Nelson; Fiscal Year: 2009
    ..A better understanding of the immunologic factors that determine resolution or persistence of the infection may help in the design of therapies and vaccines for the control of HCV infection. ..
  4. Assessment of vaccine/microbicide combination efficacy in the macaque model
    CECILIA C CHENG MAYER; Fiscal Year: 2010
    ..We believe that information gained from the proposed studies will be invaluable for the design, testing and interpretation of preventive strategies against HIV infection in women. ..
  5. Screen for Mycobacterium Tuberculosis (RMI)
    E White; Fiscal Year: 2005
    ..tuberculosis. 3) To study the effect of these novel inhibitors on the pantothenate pathway in M. smegmatis. 4) To co-crystallize these compounds with pantothenate synthetase to study their mode of binding ..
  6. Control of translation by VSV
    DOUGLAS LYLES; Fiscal Year: 2008
    ..Thus we expect to gain new insight into regulation of cellular translation under other conditions where the activities of translation initiation factors are inhibited. ..
  7. Reconstitution of Protective CMV Immunity and Immune Regulation After HAART
    Adriana Weinberg; Fiscal Year: 2008
    ..These analyses will define the role of TREG in the inadequate CMV immune reconstitution of HAART recipients. [unreadable] [unreadable] [unreadable] [unreadable]..
  8. ADHESION MOLECULES IN NO MODULATED TUMORIGENESIS
    LESLEY ELLIES; Fiscal Year: 2004
    ..These studies will help to define t h e importance of NO mediated alterations in adhesion molecules in tumorigenesis and may lead to improved therapy for cancer patients. ..
  9. Role of the chronic inflammatory mediator NO in early mammary tumorigenesis
    LESLEY ELLIES; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  10. Role of SV40 in Salivary Gland Tumorigenesis
    LESLEY ELLIES; Fiscal Year: 2003
    ..Analysis of molecular changes occurring during salivary gland tumorigenesis may lead to the development of therapeutic agents for the treatment of malignant disease. ..
  11. Filovirus/cellular receptor interactions
    Wendy Maury; Fiscal Year: 2007
    ..Development of equivalent drugs for the filoviruses might prove to be successful in limiting new outbreaks. [unreadable] [unreadable]..
  12. HPV DIFFERENTIATION DEPENDENT REPLICATION
    Craig Meyers; Fiscal Year: 2003
    ..abstract_text> ..
  13. TRANSMISSION & PATHOGENESIS OF X4 & R5 SHIVS
    Cecilia Cheng Mayer; Fiscal Year: 2009
    ..abstract_text> ..
  14. Genetic Analysis of Papillomavirus Virion Morphogenesis
    Craig Meyers; Fiscal Year: 2009
    ....
  15. SELECTIVE INHIBITION OF HCV TRANSLATION BY TETRAPEPTIDE
    ALEXANDER BIRK; Fiscal Year: 2008
    ..If DAPL or related analogues can be further developed to target and inhibit HCV RNA translation, the clinical application of this kind of therapeutics might be significant. ..
  16. High Throughput Screening-Based Identification of Measles Virus Probes
    RICHARD PLEMPER; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  17. Effect of ART on 3D Oral Epithelium & KSHV/RRV Infection
    Craig Meyers; Fiscal Year: 2008
    ..Our studies in this application and future studies evolving from them will have a significant impact on health care. [unreadable] [unreadable] [unreadable]..
  18. MOLECULAR MECHANISMS OF EIAV PERSISTENCE
    JERALD OAKS; Fiscal Year: 2001
    ..These studies will provide insight into HIV persistence in HAART patients, and potentially provide a model that can be used to evaluate strategies for actual elimination of lentiviral infections. ..
  19. Development of Inhibitors Against HCV Infection
    Joshua Ojwang; Fiscal Year: 2002
    ..abstract_text> ..
  20. A NOVEL STRATEGY FOR OSTEOPOROSIS GENE THERAPY
    Joanne Douglas; Fiscal Year: 2003
    ..The realization of these Specific Aims would establish the feasibility of this approach as a rational strategy for gene therapy in patients with end-stage, low-turnover osteoporosis. ..
  21. TRIMODAL GENE THERAPY FOR PROSTATE CANCER
    SVEND FREYTAG; Fiscal Year: 2003
    ....
  22. STRUCTURE/FUNCTION RELATIONSHIP OF HIV-1
    Cecilia Cheng Mayer; Fiscal Year: 2004
    ..Since the outcome of SHIV infection via the mucosal route appears to be attenuated, it is possible that the type or extent of immune responses elicited by these two routes of immunization may differ. ..
  23. Structure-Based Design of Nipah Virus Entry Inhibitors
    RICHARD PLEMPER; Fiscal Year: 2006
    ..These will be characterized for their activity against live Nipah (aim 3). ..
  24. Development of gene transfer approaches for neuroAIDS
    Yuanan Lu; Fiscal Year: 2006
    ..Overall, the work is expected to result in significant insight into new approaches for treatment of neuroAIDS and other neurologic diseases. ..
  25. ENHANCING TUMOR VACCINES WITH CO-STIMULATORY MOLECULES
    Howard Kaufman; Fiscal Year: 2004
    ..This may have important implications for the future design of tumor vaccines in melanoma and other settings. ..
  26. Mathematical Models of Programmed CTL Proliferation
    Dominik Wodarz; Fiscal Year: 2009
    ..These are the role of effector molecules (such as perform and IFN-g) for CTL dynamics, and the role of CD4 T cell help. The modeling work will be complemented by experiments with VSV and LCMV infected mice. ..
  27. Population dynamics of a bird-borne arbovirus
    Charles Brown; Fiscal Year: 2007
    ..e., colony sites) can be reliably identified and ecological hypotheses tested. ..
  28. Adaptation of Influenza Inhibition Assays for High-throughput Screening
    James Noah; Fiscal Year: 2006
    ..The focus of this proposal is on the design and optimization of novel, robust assays that can be adapted to an automated liquid HTS system. [unreadable] [unreadable] [unreadable]..
  29. Ethnobotanical Anti-Respiratory Syncytial Virus Drugs
    Joshua Ojwang; Fiscal Year: 2003
    ..proposed commercial application: not available ..
  30. Molecular Therapy Core Centers
    Arthur Miller; Fiscal Year: 2008
    ..abstract_text> ..