blood chemical analysis

Summary

Top Publications

  1. ncbi New, small, fast acting blood glucose meters--an analytical laboratory evaluation
    Raimund Weitgasser
    1st Department of Medicine, Paracelsus Private Medical University Salzburg, St Johanns Spital, Salzburg, Austria
    Swiss Med Wkly 137:536-40. 2007
  2. ncbi Age-related variations in hematologic and plasma biochemical test results in Beagles and Labrador Retrievers
    E Jean Harper
    Waltham Centre for Pet Nutrition, Waltham on the Wolds, Melton Mowbray, Leicestershire, LE14 4RT, UK
    J Am Vet Med Assoc 223:1436-42. 2003
  3. ncbi Haematology, blood chemistry and urine parameters of free-ranging plains viscachas (Lagostomus maximus) in Argentina determined by use of a portable blood analyser (i-STAT) and conventional laboratory methods
    C J Wenker
    Zoo Basel, Binningerstrasse 40, CH 4054 Basel, Switzerland
    J Vet Med A Physiol Pathol Clin Med 54:260-4. 2007
  4. ncbi An unusual case of a primary blood collection tube with floating separator gel
    Massimo Daves
    Clinical Biochemical Laboratory, San Maurizio Regional Hospital, Via L Boehler 5, Balzano, Italy
    J Clin Lab Anal 26:246-7. 2012
  5. pmc Reference intervals in healthy adult Ugandan blood donors and their impact on conducting international vaccine trials
    Leigh Anne Eller
    U S Military HIV Research Program, Rockville, Maryland, United States of America
    PLoS ONE 3:e3919. 2008
  6. ncbi Optimized metabolite extraction from blood serum for 1H nuclear magnetic resonance spectroscopy
    Stefano Tiziani
    Henry Wellcome Building for Biomolecular NMR Spectroscopy, CR UK Institute for Cancer Studies, University of Birmingham, Birmingham B15 2TT, UK
    Anal Biochem 377:16-23. 2008
  7. pmc Reference ranges for the clinical laboratory derived from a rural population in Kericho, Kenya
    Rukia S Kibaya
    Walter Reed Project, U S Military HIV Research Program, Kericho, Kenya
    PLoS ONE 3:e3327. 2008
  8. pmc Conventional or physicochemical approach in intensive care unit patients with metabolic acidosis
    Mirjam Moviat
    Department of Intensive Care Medicine, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Crit Care 7:R41-5. 2003
  9. ncbi Effect of marathon running on hematologic and biochemical laboratory parameters, including cardiac markers
    Alexander Kratz
    Department of Pathology, Massachusetts General Hospital, and Harvard Medical School, Boston 02114, USA
    Am J Clin Pathol 118:856-63. 2002
  10. ncbi Non-HDL cholesterol shows improved accuracy for cardiovascular risk score classification compared to direct or calculated LDL cholesterol in a dyslipidemic population
    Hendrick E van Deventer
    National Institutes of Health, Department of Laboratory Medicine, Bethesda, MD 20892 1508, USA
    Clin Chem 57:490-501. 2011

Research Grants

Detail Information

Publications265 found, 100 shown here

  1. ncbi New, small, fast acting blood glucose meters--an analytical laboratory evaluation
    Raimund Weitgasser
    1st Department of Medicine, Paracelsus Private Medical University Salzburg, St Johanns Spital, Salzburg, Austria
    Swiss Med Wkly 137:536-40. 2007
    ..We questioned whether accuracy and precision of these new, small and light weight devices would meet analytical laboratory standards and tested four meters with the above mentioned conditions...
  2. ncbi Age-related variations in hematologic and plasma biochemical test results in Beagles and Labrador Retrievers
    E Jean Harper
    Waltham Centre for Pet Nutrition, Waltham on the Wolds, Melton Mowbray, Leicestershire, LE14 4RT, UK
    J Am Vet Med Assoc 223:1436-42. 2003
    ..To investigate age-related variations in results of hematologic and plasma biochemical tests performed on dogs of 2 common breeds...
  3. ncbi Haematology, blood chemistry and urine parameters of free-ranging plains viscachas (Lagostomus maximus) in Argentina determined by use of a portable blood analyser (i-STAT) and conventional laboratory methods
    C J Wenker
    Zoo Basel, Binningerstrasse 40, CH 4054 Basel, Switzerland
    J Vet Med A Physiol Pathol Clin Med 54:260-4. 2007
    ..In general, correlation and agreement between the two methods were low for most parameters...
  4. ncbi An unusual case of a primary blood collection tube with floating separator gel
    Massimo Daves
    Clinical Biochemical Laboratory, San Maurizio Regional Hospital, Via L Boehler 5, Balzano, Italy
    J Clin Lab Anal 26:246-7. 2012
    ..The aspiration of gel along with the sample matrix might also spuriously modify the test results, since an inappropriate amount of serum or plasma would be analyzed...
  5. pmc Reference intervals in healthy adult Ugandan blood donors and their impact on conducting international vaccine trials
    Leigh Anne Eller
    U S Military HIV Research Program, Rockville, Maryland, United States of America
    PLoS ONE 3:e3919. 2008
    ..In order to ensure enrollment of healthy participants and proper safety evaluation of vaccine candidates, established reference intervals for clinical tests are required in the target population...
  6. ncbi Optimized metabolite extraction from blood serum for 1H nuclear magnetic resonance spectroscopy
    Stefano Tiziani
    Henry Wellcome Building for Biomolecular NMR Spectroscopy, CR UK Institute for Cancer Studies, University of Birmingham, Birmingham B15 2TT, UK
    Anal Biochem 377:16-23. 2008
    ..We also describe a new method to recover the hydrophobic fraction for ultrafiltration with good reproducibility...
  7. pmc Reference ranges for the clinical laboratory derived from a rural population in Kericho, Kenya
    Rukia S Kibaya
    Walter Reed Project, U S Military HIV Research Program, Kericho, Kenya
    PLoS ONE 3:e3327. 2008
    ....
  8. pmc Conventional or physicochemical approach in intensive care unit patients with metabolic acidosis
    Mirjam Moviat
    Department of Intensive Care Medicine, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Crit Care 7:R41-5. 2003
    ..Metabolic acidosis is the most frequent acid-base disorder in the intensive care unit. The optimal analysis of the underlying mechanisms is unknown...
  9. ncbi Effect of marathon running on hematologic and biochemical laboratory parameters, including cardiac markers
    Alexander Kratz
    Department of Pathology, Massachusetts General Hospital, and Harvard Medical School, Boston 02114, USA
    Am J Clin Pathol 118:856-63. 2002
    ..We provide a table of modified reference ranges (or expected ranges) for basic biochemical, cardiac, and hematologic laboratory parameters for marathon runners...
  10. ncbi Non-HDL cholesterol shows improved accuracy for cardiovascular risk score classification compared to direct or calculated LDL cholesterol in a dyslipidemic population
    Hendrick E van Deventer
    National Institutes of Health, Department of Laboratory Medicine, Bethesda, MD 20892 1508, USA
    Clin Chem 57:490-501. 2011
    ....
  11. ncbi Interference with serum indices measurement, but not chemical analysis, on the Roche Modular by Patent Blue V
    Denise Darby
    Department of Clinical Biochemistry, Wythenshawe Hospital, Manchester, UK
    Ann Clin Biochem 45:289-92. 2008
    ..We recently discovered three cases with falsely elevated lipaemic indices on the Roche Modular, following intramammary injection of Patent Blue. This, and other potential interferences by Patent Blue, is examined in this study...
  12. ncbi Protein biomarker discovery and validation: the long and uncertain path to clinical utility
    Nader Rifai
    Departments of Laboratory Medicine and Pathology, Children s Hospital Boston and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Nat Biotechnol 24:971-83. 2006
    ....
  13. ncbi Diagnosing diabetic nephropathy by 1H NMR metabonomics of serum
    Ville Petteri Mäkinen
    Folkhalsan Institute of Genetics, Folkhalsan Research Center, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    MAGMA 19:281-96. 2006
    ..Conversely, in this study, these independent diagnostic data are used to provide a realistic testing case for applying (1)H NMR metabonomics of serum in a diagnostic fashion...
  14. ncbi Hematological indices and iron status in athletes of various sports and performances
    Yorck Olaf Schumacher
    Department of Prevention, Rehabilitation and Sports Medicine, University of Freiburg, Germany
    Med Sci Sports Exerc 34:869-75. 2002
    ..The purpose of this epidemiological study was to investigate the characteristics of the red blood cell system and the iron metabolism in athletes of different sporting disciplines and at different levels of performance...
  15. pmc A magneto-optic route toward the in vivo diagnosis of malaria: preliminary results and preclinical trial data
    Dave M Newman
    School of Engineering, Computing and Mathematics, University of Exeter, Exeter EX4 4QF, United Kingdom
    Biophys J 95:994-1000. 2008
    ....
  16. ncbi Gadolinium magnetic resonance contrast agents produce analytic interference in multiple serum assays
    Kerry A S Proctor
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, USA
    Am J Clin Pathol 121:282-92. 2004
    ..Likewise, certain analytic methods are more prone to interference, while others not affected...
  17. ncbi State of the art in trueness and interlaboratory harmonization for 10 analytes in general clinical chemistry
    W Greg Miller
    Department of Pathology, Virginia Commonwealth University, PO Box 980286, Richmond, VA 23298 0286, USA
    Arch Pathol Lab Med 132:838-46. 2008
    ..Harmonization and standardization of results among different clinical laboratories is necessary for clinical practice guidelines to be established...
  18. ncbi Evaluation of the effect of two gadolinium-containing contrast-enhancing agents, gadobutrol and gadoxetate disodium, on colorimetric calcium determinations in serum and plasma
    Andrea Löwe
    Bayer HealthCare, Berlin, Germany
    Invest Radiol 46:366-9. 2011
    ..To determine the extent to which the gadolinium-containing contrast agents, gadobutrol (Gadovist) and gadoxetate disodium (Primovist/Eovist), interfere with the colorimetric measurement of calcium concentrations in serum and plasma...
  19. ncbi [Haemolysis and turbidity influence on three analysis methods of quantitative determination of total and conjugated bilirubin on ADVIA 1650]
    E Gobert De Paepe
    Laboratoire de Biochimie Hormonologie, Hopital Robert Debre, Paris
    Ann Biol Clin (Paris) 66:175-82. 2008
    ..Our data suggest that both Siemens and Diasys methods allow to measure accurately total and conjugated bilirubin in hemolytic and lipemic samples, nevertheless, the Siemens methodology is less affected by these interferences...
  20. ncbi Correction of patient results for Beckman Coulter LX-20 assays affected by interference due to hemoglobin, bilirubin or lipids: a practical approach
    Henricus J Vermeer
    Department of Clinical Chemistry and Hematology, Haga Hospital, The Hague, The Netherlands
    Clin Chem Lab Med 45:114-9. 2007
    ..For all interferants (hemoglobin, bilirubin, lipids), relatively simple algorithms are derived that can easily be implemented in the clinical laboratory...
  21. ncbi Clinical and economic impact of falsely decreased calcium values caused by gadoversetamide interference
    Manish J Gandhi
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Ave, Box 8118, St Louis, MO 63110, USA
    AJR Am J Roentgenol 190:W213-7. 2008
    ....
  22. ncbi Hematocrit and plasma chemistry values in adult collared scops owls (Otus lettia) and crested serpent eagles (Spilornis cheela hoya)
    Fang Tse Chan
    Department of Veterinary Medicine, National Chung Hsing University, 250 Kuo Kuang Road, Taichung, Taiwan 402, R O C
    J Vet Med Sci 74:893-8. 2012
    ....
  23. ncbi Interference of gadolinium on the measurement of selenium in human serum by inductively coupled plasma-quadrupole mass spectrometry
    Alan Walter
    Trace Element Laboratory, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey GU27XH, UK
    Ann Clin Biochem 48:176-7. 2011
    ....
  24. ncbi Raman spectroscopy offers great potential for the nondestructive confirmatory identification of body fluids
    Kelly Virkler
    Department of Chemistry, University at Albany, SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Forensic Sci Int 181:e1-5. 2008
    ..Overall, this preliminary study demonstrates the great potential of Raman spectroscopy for nondestructive, confirmatory identification of body fluids for forensic purposes...
  25. ncbi An ELISA method for the identification of salivary amylase
    Lawrence Quarino
    Office of Chief Medical Examiner, Department of Forensic Biology, New York City, USA
    J Forensic Sci 50:873-6. 2005
    ..2 units. Of these swabs, the 1:100 dilution showed the lowest activity (0.048). This value is still more than ten times that of the non-saliva containing swab with the highest activity...
  26. ncbi Establishment of long-term monitoring system for blood chemistry data by the national health and nutrition survey in Japan
    Masakazu Nakamura
    Osaka Medical Center for Health Science and Promotion, CRMLN Lipid Reference Laboratory, Osaka, Japan
    J Atheroscler Thromb 15:244-9. 2008
    ..We established a monitoring system for the annual follow-up of blood chemistry data obtained by the National Health and Nutrition Survey in Japan...
  27. ncbi Serum biochemical values of adult ostriches (Struthio camelus) anesthetized with xylazine, ketamine, and isoflurane
    Fahd A Al-Sobayil
    College of Agriculture and Veterinary Medicine, Qassim University, Buraydah 51452, PO Box 6622, Saudi Arabia
    J Avian Med Surg 25:97-101. 2011
    ..These results should be taken into account when blood samples are evaluated in chemically immobilized or anesthetized ostriches...
  28. ncbi Comparison of two transcutaneous bilirubinometers--Minolta AirShields Jaundice Meter JM103 and Spectrx Bilicheck--in Thai neonates
    Suwimol Sanpavat
    Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    Southeast Asian J Trop Med Public Health 36:1533-7. 2005
    ..The accuracy of JM in predicting TSB was higher than BC at all TSB levels. Operating the JM was simple and uncomplicated. It would be suitable for clinical use when a number of personnel perform the measurement...
  29. ncbi Limits and pitfalls of Athlete's Biological Passport
    Giuseppe Banfi
    IRCCS Galeazzi and University of Milan, Milan, Italy
    Clin Chem Lab Med 49:1417-21. 2011
    ..The ABP needs of additional evidences and of scientific debate...
  30. ncbi Novel method to measure serum levels of des-gamma-carboxy prothrombin for hepatocellular carcinoma in patients taking warfarin: a preliminary report
    Hidenori Toyoda
    Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan
    Cancer Sci 103:921-5. 2012
    ..The novel NX-DCP ratio identifies patients on warfarin with elevated DCP due to HCC and is useful as a tumor marker for HCC in this patient subpopulation...
  31. ncbi Evacuated blood-collection tubes for haematological tests - a quality evaluation prior to their intended use for specimen collection
    Natasa Gros
    Faculty of Chemistry and Chemical Technology, University of Ljubljana, Askerceva 5, 1000 Ljubljana, Slovenia
    Clin Chem Lab Med 51:1043-51. 2013
    ..No testing procedures that would give an insight into the anticoagulant concentration that can be expected for blood samples after specimen collection have been available up until now...
  32. ncbi Analytical interferences resulting from intravenous lipid emulsion
    Ami M Grunbaum
    Division of Medical Biochemistry, Department of Medicine, McGill University Health Centre, Montreal, QC, Canada
    Clin Toxicol (Phila) 50:812-7. 2012
    ..Lipid resuscitation therapy using intravenous lipid emulsion (IVLE) for drug overdoses has gained widespread use. However, there is little information regarding its adverse effects...
  33. ncbi Biochemical findings in common inborn errors of metabolism
    Marzia Pasquali
    University of Utah, and ARUP Laboratories, 500 Chipeta Way, Salt Lake City, UT 84108, USA
    Am J Med Genet C Semin Med Genet 142:64-76. 2006
    ..Early treatment can improve the outcome of these disorders...
  34. ncbi [6S]-5-Methyltetrahydrofolate is at least as effective as folic acid in preventing a decline in blood folate concentrations during lactation
    Lisa A Houghton
    Department of Nutritional Sciences, University of Toronto, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Am J Clin Nutr 83:842-50. 2006
    ..No data, however, are available on the effect of supplemental [6S]-5-methylTHF on blood folate concentrations during lactation...
  35. pmc Comparison of a new transcutaneous bilirubinometer (Bilimed) with serum bilirubin measurements in preterm and full-term infants
    Tanja Karen
    Clinic of Neonatology, University Hospital Zurich, Switzerland
    BMC Pediatr 9:70. 2009
    ..No contact with the skin is needed during measurement, no additional material costs occur. Our aim was to assess the agreement between the Bilimed and serum bilirubin in preterm and term infants of different skin colours...
  36. ncbi Assay-specific differences in lipemic interference in native and intralipid-supplemented samples
    Joshua A Bornhorst
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT 84108, USA
    Clin Chem 50:2197-201. 2004
  37. ncbi Effect of acute dietary standardization on the urinary, plasma, and salivary metabolomic profiles of healthy humans
    Marianne C Walsh
    Nutrition Unit, Division of Clinical and Molecular Medicine, Trinity College, Dublin, Ireland
    Am J Clin Nutr 84:531-9. 2006
    ..Metabolomics in human nutrition research is faced with the challenge that changes in metabolic profiles resulting from diet may be difficult to differentiate from normal physiologic variation...
  38. ncbi The value of the chloride: sodium ratio in differentiating the aetiology of metabolic acidosis
    A Durward
    Paediatric Intensive Care Unit, Guy s Hospital, London, UK
    Intensive Care Med 27:828-35. 2001
    ..Thus, the Cl:Na ratio could be used as a simple alternative to the anion gap in identifying raised TA...
  39. ncbi Evaluating interference caused by lipemia
    Martin H Kroll
    Clin Chem 50:1968-9. 2004
  40. pmc Unreliability of triglyceride measurement to predict turbidity induced interference
    P J Twomey
    Clinical Biochemistry, St John s Hospital, Livingston EH54 6PP, UK
    J Clin Pathol 56:861-2. 2003
    ..The evaluation of turbidity induced interference needs to be standardised using objective assessments of turbidity...
  41. ncbi Serum phosphate abnormalities in the emergency department
    Joseph R Shiber
    Department of Emergency Medicine, East Carolina University Brody School of Medicine, Greenville, North Carolina 27858, USA
    J Emerg Med 23:395-400. 2002
    ..Hemodialysis may be required for severe hyperphosphatemia with symptomatic hypocalcemia...
  42. ncbi Evaluation of commutability of control materials
    Emmanuel Brion
    Laboratoire de biochimie appliquée, UFR des Sciences Pharmaceutiques, Universite Louis Pasteur de Strasbourg, Ilkirch, France
    Clin Chem Lab Med 40:625-30. 2002
    ..We propose to verify the commutability of materials before their use in an external quality control assessement...
  43. ncbi The Nordic Trueness Project 2002: use of reference measurement procedure values in a general clinical chemistry survey
    M M Pedersen
    DEKS, 54M1 Herlev University Hospital, DK 2730 Herlev, Denmark
    Scand J Clin Lab Invest 64:309-20. 2004
    ..The findings should be used to discuss to what extent reference measurement procedure values are useful and cost-efficient for this type of material...
  44. ncbi Simultaneous quantification of sirolimus, everolimus, tacrolimus and cyclosporine by liquid chromatography-mass spectrometry (LC-MS)
    Michael Deters
    Institute of Pharmacology, Medical School Hannover, Germany
    Clin Chem Lab Med 40:285-92. 2002
    ..The simultaneous quantification of blood levels by LC-MS seems to be the method of choice in transplanted patients receiving multiple immunosuppressants...
  45. ncbi Multicenter evaluation of the interference of hemoglobin, bilirubin and lipids on Synchron LX-20 assays
    Gerard Steen
    Department of Clinical Chemistry and Hematology, Bronovo Hospital, The Hague, The Netherlands
    Clin Chem Lab Med 44:413-9. 2006
    ..Use of the cutoff indices presented here facilitates optimal use of the LX-20 indices to prevent reporting of wrong results due to interference...
  46. ncbi Metabolic characterisation of plasma in juveniles with glycogen storage disease type 1a (GSD1a) by high-resolution (1)H NMR spectroscopy
    Iola F Duarte
    CICECO, Department of Chemistry, Campus Universitario de Santiago, University of Aveiro, 3810 193 Aveiro, Portugal
    NMR Biomed 20:401-12. 2007
    ..The specificity of the changes observed to GSD1a is discussed, together with the recognised potential of NMR and pattern recognition methods for aiding the diagnosis of GSD1a...
  47. ncbi Hepcidin: from discovery to differential diagnosis
    Erwin H J M Kemna
    Department of Clinical Chemistry, Radboud University Nijmegen Medical Centre, P O Box 9101 6500 HB Nijmegen, The Netherlands
    Haematologica 93:90-7. 2008
    ..Ongoing studies in humans should provide us with more information on the etiology of iron metabolism disorders in order to create new therapeutic strategies and improve differential diagnosis protocols for these diseases...
  48. ncbi Proteomics meets blood banking: identification of protein targets for the improvement of platelet quality
    Peter Schubert
    Canadian Blood Services, Centre for Blood Research and the Department of Pathology and Laboratory Medicine, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC, Canada
    J Proteomics 73:436-44. 2010
    ....
  49. ncbi Influence of tourniquet application on venous blood sampling for serum chemistry, hematological parameters, leukocyte activation and erythrocyte mechanical properties
    MelIke Cengiz
    Department of Anesthesiology and ICU, Akdeniz University Faculty of Medicine, Antalya, Turkey
    Clin Chem Lab Med 47:769-76. 2009
    ..The aim of the present study was to define the optimal sampling time after tourniquet removal to avoid adverse impact on laboratory analytes...
  50. ncbi Seven direct methods for measuring HDL and LDL cholesterol compared with ultracentrifugation reference measurement procedures
    W Greg Miller
    Virginia Commonwealth University, Richmond, VA, USA
    Clin Chem 56:977-86. 2010
    ..Methods from 7 manufacturers and 1 distributor for directly measuring HDL cholesterol (C) and LDL-C were evaluated for imprecision, trueness, total error, and specificity in nonfrozen serum samples...
  51. ncbi High-throughput genotyping on archived dried blood spot samples
    Mads V Hollegaard
    Department of Clinical Biochemistry and Immunology, Statens Serum Institut, Copenhagen, Denmark
    Genet Test Mol Biomarkers 13:173-9. 2009
    ..For evaluation of the biobank samples, we included variable factors: time of storage, gDNA, and whole-genome amplified DNA (wgaDNA) concentrations and the Illumina quality metric (GenCall score)...
  52. ncbi Blood, urine, and sweat (BUS) study: monitoring and elimination of bioaccumulated toxic elements
    Stephen J Genuis
    University of Alberta, Edmonton, AB, Canada
    Arch Environ Contam Toxicol 61:344-57. 2011
    ..Sweat analysis should be considered as an additional method for monitoring bioaccumulation of toxic elements in humans...
  53. pmc Effects of 21 days of bed rest, with or without artificial gravity, on nutritional status of humans
    S R Zwart
    Universities Space Research Association, Houston, USA
    J Appl Physiol (1985) 107:54-62. 2009
    ..These data provide evidence that artificial gravity itself does not negatively affect nutritional status during bed rest. Likewise, artificial gravity has no protective effect on nutritional status during bed rest...
  54. ncbi Japanese standard reference material for JDS Lot 2 haemoglobin A1c. I: Comparison of Japan Diabetes Society-assigned values to those obtained by the Japanese and USA domestic standardization programmes and by the International Federation of Clinical Chemi
    Makoto Tominaga
    Department of Laboratory Medicine, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Ann Clin Biochem 42:41-6. 2005
    ....
  55. pmc Pyometra in bitches induces elevated plasma endotoxin and prostaglandin F2alpha metabolite levels
    R Hagman
    Department of Small Animal Clinical Sciences, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Box 7037, SE 75007 Uppsala, Sweden
    Acta Vet Scand 47:55-67. 2006
    ..Treatment inhibiting prostaglandin biosynthesis and related compounds could be beneficial for bitches suffering from pyometra...
  56. ncbi Differentiation between pyometra and cystic endometrial hyperplasia/mucometra in bitches by prostaglandin F2alpha metabolite analysis
    R Hagman
    Department of Small Animal Clinical Sciences, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Box 7037, SE 75007 Uppsala, Sweden
    Theriogenology 66:198-206. 2006
    ..The results of the present study showed that PG-metabolite analysis is valuable in the diagnosis and prediction of severity of uterine diseases...
  57. ncbi Results of a 90-day safety assurance study with rats fed grain from corn borer-protected corn
    B G Hammond
    Monsanto Company, Product Safety Center, 800 North Lindbergh Blvd, Bldg O3F, St Louis, MO 63167, USA
    Food Chem Toxicol 44:1092-9. 2006
    ..This study complements extensive agronomic, compositional and farm animal feeding studies with MON 810 grain, confirming that it is as safe and nutritious as grain from existing commercial corn varieties...
  58. ncbi Evaluation of four point-of-care meters for rapid determination of blood lactate concentrations in dogs
    Mark J Acierno
    Department of Veterinary Clinical Science, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70810, USA
    J Am Vet Med Assoc 230:1315-8. 2007
    ..To determine whether blood lactate values determined in dogs with 4 commercially available point-of-care meters were in agreement with values determined with a critical care laboratory blood analyzer...
  59. ncbi The accuracy of the Lactate Pro hand-held analyser to determine blood lactate in healthy dogs
    O Tas
    Department of Medicine and Clinical Biology of Small Animals, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
    J Small Anim Pract 49:504-8. 2008
    ..The objective of this study was to determine the accuracy of the Lactate Pro hand-held analyser in measuring blood lactate levels...
  60. ncbi Anion gap, anion gap corrected for albumin, and base deficit fail to accurately diagnose clinically significant hyperlactatemia in critically ill patients
    Lakhmir S Chawla
    Department of Critical Care Medicine and Anesthesiology, The George Washingto Unitversity Medical Center, Washington, DC, USA
    J Intensive Care Med 23:122-7. 2008
    ..Serum lactate should be measured in all critically ill adults in whom hypoperfusion is suspected...
  61. ncbi Results of a 90-day safety assurance study with rats fed grain from corn rootworm-protected corn
    B Hammond
    Monsanto Company, 800 North Lindbergh Blvd, St Louis, MO 63167, USA
    Food Chem Toxicol 44:147-60. 2006
    ..This study complements extensive agronomic, compositional and farm animal feeding studies with MON 863 grain, confirming that it is as safe and nutritious as existing conventional corn varieties...
  62. ncbi [Measurement of triglycerides in capillary blood: validation against whole blood measurement]
    Ana Alegría Barrero
    Departamento de Cardiologia, Clinica Universidad de Navarra, Pamplona, Espana
    Med Clin (Barc) 133:375-8. 2009
    ..Capillary analysis of TG would facilitate the recognition of those abnormalities. The aim of the present study was to assess the concordance between TG values measured in capillary (Accutrend GCT Roche Diagnostics) and total blood...
  63. ncbi Nutritional status assessment before, during, and after long-duration head-down bed rest
    Sara R Zwart
    Nutritional Biochemistry Laboratory, Human Adaptation and Countermeasures Division, NASA Johnson Space Center, Houston, TX 77058, USA
    Aviat Space Environ Med 80:A15-22. 2009
    ..Bed rest is a valuable ground-based model for many of the physiological changes that are associated with spaceflight. Nutritional changes during and after 60 or 90 d of head-down bed rest were evaluated...
  64. ncbi Suspension microarrays for the identification of the response patterns in hyperinflammatory diseases
    Hsin Yun Hsu
    NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany
    Med Eng Phys 30:976-83. 2008
    ....
  65. ncbi Safety assessment of Cry1C protein from genetically modified rice according to the national standards of PR China for a new food resource
    Sishuo Cao
    Laboratory of Food Safety and Molecular Biology, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, PR China
    Regul Toxicol Pharmacol 58:474-81. 2010
    ..Taken together, these data indicate that the Cry1C protein is not a potential allergen or toxin...
  66. ncbi Accuracy of transcutaneous bilirubinometry compare to total serum bilirubin measurement
    Jantana Panburana
    Department of Pediatrics, Faculty of Medicine, Srinakharinwirot University, Bangkok, Thailand
    J Med Assoc Thai 93:S81-6. 2010
    ..Neonatal hyperbilirubinemia leads to bilirubin neurotoxicity. Noninvasive transcutaneous bilirubin (TcB) levels can be used as a screening tool for total serum bilirubin (TSB) levels...
  67. ncbi Evaluation of the VITROS 5,1 FS chemistry system in a large pediatric laboratory
    Kurt Herkner
    Allgemeines Krankenhaus, Universitäts Kinderklinik, Vienna, Austria
    Clin Lab 53:17-26. 2007
    ..76. An explanation for the difference could not be found. The VITROS 5,1 FS analytical system is a reliable routine instrument which fits into a large pediatric laboratory of a university...
  68. ncbi Assessment of a transcutaneous device in the evaluation of neonatal hyperbilirubinemia in a primarily Hispanic population
    William D Engle
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9063, USA
    Pediatrics 110:61-7. 2002
    ....
  69. ncbi Results of an international round robin for the quantification of serum non-transferrin-bound iron: Need for defining standardization and a clinically relevant isoform
    Esther M G Jacobs
    Department of Clinical Chemistry, Radboud University Nijmegen Medical Center, 6500 HB Nijmegen, The Netherlands
    Anal Biochem 341:241-50. 2005
    ....
  70. ncbi Lactate as a diagnostic test for septic peritoneal effusions in dogs and cats
    Garrett M Levin
    Department of Surgery, The E and M Bobst Hospital, The Animal Medical Center, New York, New York 10021, USA
    J Am Anim Hosp Assoc 40:364-71. 2004
    ..Peritoneal fluid lactate concentration and blood to fluid lactate difference were not accurate tests for detecting septic peritoneal effusions in cats...
  71. ncbi Use of relaxation-edited one-dimensional and two dimensional nuclear magnetic resonance spectroscopy to improve detection of small metabolites in blood plasma
    Huiru Tang
    Biological Chemistry, Biomedical Sciences, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, SW7 2AZ, London, UK
    Anal Biochem 325:260-72. 2004
    ..Both pulse sequences and experimental results are discussed for T(1)-, T(1rho)-, and T(2)-filtered COSY, T(2)-filtered phase-sensitive DQF-COSY, and T(1), T(1rho)-, and T(2)-filtered TOCSY NMR...
  72. ncbi The comparison of plasma deproteinization methods for the detection of low-molecular-weight metabolites by (1)H nuclear magnetic resonance spectroscopy
    Clare A Daykin
    Biological Chemistry, Biomedical Sciences Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK
    Anal Biochem 304:220-30. 2002
    ....
  73. ncbi Reference values for trace and ultratrace elements in human serum determined by double-focusing ICP-MS
    C S Muñiz
    Department of Physical and Analytical Chemistry, University of Oviedo, Spain
    Biol Trace Elem Res 82:259-72. 2001
    ..High levels of Al, Cr, Sr, Mo, Mn, Pb, U, Co, and Cu and low levels of Fe, Zn, and Rb were found in the serum samples from hemodialysis patients compared to the corresponding reference values observed in this work...
  74. ncbi Messenger RNA profiling: a prototype method to supplant conventional methods for body fluid identification
    Jane Juusola
    Graduate Program in Biomolecular Science, University of Central Florida, PO Box 162366, Orlando, FL 32816 2366, USA
    Forensic Sci Int 135:85-96. 2003
    ..Collectively these findings constitute the basis of a prototype RNA based assay system that may eventually supplant conventional methods for body fluid identification...
  75. ncbi Effect of general anesthesia and minor surgical trauma on urine and serum measurements in horses
    Zara E Watson
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis 95616, USA
    Am J Vet Res 63:1061-5. 2002
    ..To characterize the effect of general anesthesia and minor surgery on renal function in horses...
  76. ncbi Hematology and plasma biochemistry reference range values for free-ranging desert tortoises in Arizona
    Vanessa M Dickinson
    Research Branch, Arizona Game and Fish Department, 2221 W Greenway Rd, Phoenix, Arizona 85023, USA
    J Wildl Dis 38:143-53. 2002
    ..Seasonal and annual differences in hematology and blood chemistry were related to rainfall patterns, forage availability, and physiological condition...
  77. ncbi Length of sedimentation reaction in blood: a comparison of the test 1 ESR system with the ICSH reference method and the sedisystem 15
    Adolfo Romero
    Department of Haematology, H C U Virgen de la Victoria, Malaga, Spain
    Clin Chem Lab Med 41:232-7. 2003
    ..In addition, due to its operational characteristics (60 samples/20 min) it is a suitable tool for clinical laboratories with a high work load as well as for emergency laboratories...
  78. ncbi Performance evaluation of blood glucose monitoring devices
    Ellen T Chen
    Center for Devices and Radiological Health, US Food and Drug Administration, Rockville, Maryland, USA
    Diabetes Technol Ther 5:749-68. 2003
    ..This study describes the current state of performance of blood glucose monitoring devices and points out those factors that should be assessed during evaluation of new devices...
  79. ncbi Blood values of juvenile northern elephant seals (Mirounga angustirostris) obtained using a portable clinical analyzer
    R Scott Larsen
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA
    Vet Clin Pathol 31:106-10. 2002
    ..These abnormalities could be detected rapidly using a portable blood analyzer, but results with this analysis method do not necessarily equate with those obtained using other techniques...
  80. ncbi Advanced oxidation protein products (AOPP) for monitoring oxidative stress in critically ill patients: a simple, fast and inexpensive automated technique
    Laszlo Selmeci
    Department of Cardiovascular Surgery, Faculty of Medicine, Semmelweis University, Budapest, Hungary
    Clin Chem Lab Med 43:294-7. 2005
    ....
  81. ncbi A canine model of septic shock: balancing animal welfare and scientific relevance
    Peter C Minneci
    Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Physiol Heart Circ Physiol 293:H2487-500. 2007
    ..The integration into this model of both specific and supportive titrated therapies routinely used in septic patients may provide a more realistic setting to evaluate therapies for sepsis...
  82. ncbi Normal hematologic and biochemical values for prelaying greater sage grouse (Centrocercus urophasianus) and their influence on chick survival
    Mike R Dunbar
    U S Fish and Wildlife Service, Sheldon Hart Mountain National Wildlife Refuge Complex, P O Box 111, Lakeview, Oregon 97630, USA
    J Zoo Wildl Med 36:422-9. 2005
    ..These parameters are not only indicative of the nutritional status of prelaying hens but may be associated with nutritional quality of the habitat and therefore have important management significance...
  83. ncbi Comparison of mid-infrared and Raman spectroscopy in the quantitative analysis of serum
    D Rohleder
    Roche Diagnostics GmbH, Mannheim, Germany
    J Biomed Opt 10:031108. 2005
    ..In our experiments vibrational spectroscopy-based quantification appears to be limited to accuracies in the 0.1 mmol/l range...
  84. ncbi The effect of smoking, smoking cessation, and passive smoke exposure on common laboratory values in clinical settings: a review of the evidence
    Jeannette O Andrews
    Department of Health Environments and Systems, School of Nursing, Medical College of Georgia, EB 204, 997 St Sebastian Way, Augusta, GA 30912, USA
    Crit Care Nurs Clin North Am 18:63-9, xii. 2006
    ..This article addresses the effects of active and passive smoking and cessation on common parameters of hematology, hemostasis, immunology and inflammation, and chemistry laboratory tests...
  85. ncbi Canine cancer screening via ultraviolet absorbance and fluorescence spectroscopy of serum proteins
    Bryan D Dickerson
    Luna Innovations Incorporated, 3157 State Street, Blacksburg, Virginia 24060, USA
    Appl Opt 46:8080-8. 2007
    ..7 to 3.7 g/dL). Of the dogs that met these criteria, only 20% were given a false positive label by this cancer screening test...
  86. ncbi Measurement of rheologic property of blood by a falling-ball blood viscometer
    Yoko Eguchi
    Laboratory of Biofluid Dynamics, Research Institute for Electronic Science, Hokkaido University, North 12, West 6, North District, Sapporo, 060 0812, Japan
    Ann Biomed Eng 36:545-53. 2008
    ..In contrast to this, in the case of the whole blood in which massive aggregates were formed, the viscosity obtained with a falling-ball viscometer was much larger than that obtained with a cone-plate viscometer...
  87. ncbi Impact of external haematology proficiency testing programme on quality of laboratories
    Renu Saxena
    Department of Haematology, All India Institute of Medical Sciences, New Delhi, India
    Indian J Med Res 126:428-32. 2007
    ....
  88. ncbi Computational prediction models for early detection of risk of cardiovascular events using mass spectrometry data
    Tuan D Pham
    School of Information Technology and Electrical Engineering, The University of New South Wales, ADFA, Canberra, ACT 2006, Australia
    IEEE Trans Inf Technol Biomed 12:636-43. 2008
    ..The proposed computational strategies are very promising for predicting major adverse cardiac events within six months...
  89. ncbi Biochemical and hematologic values for 18 clinically healthy radiated tortoises (Geochelone radiata) on St Catherines Island, Georgia
    Julia Zaias
    University of Miami, Department of Pathology, Division of Comparative Pathology and Avian and Wildlife Diagnostic Laboratory, Miami, FL, USA
    Vet Clin Pathol 35:321-5. 2006
    ..Captive breeding programs have generated data on the breeding behavior and ecology of G radiata; however, hematologic and biochemical data also are critically important in managing populations...
  90. ncbi Normal haematology and blood biochemistry of wild Nile crocodiles (Crocodylus niloticus) in the Okavango Delta, Botswana
    C J Lovely
    Gobabis Veterinary Practise, PO Box 1424, Gobabis, Namibia
    J S Afr Vet Assoc 78:137-44. 2007
    ..The values reported here will be useful in diagnostic investigations in both zoo and farmed Nile crocodiles...
  91. ncbi Hematology, plasma chemistry, and serology of the flightless cormorant (Phalacrocorax harrisi) in the Galapagos Islands, Ecuador
    Erika K Travis
    Saint Louis Zoo, One Government Dr, Saint Louis, Missouri 63110, USA
    J Wildl Dis 42:133-41. 2006
    ..The overall negative serologic findings of this research suggest that the flightless cormorant is an immunologically naïve species, which may have a reduced capacity to cope with the introduction of novel pathogens...
  92. ncbi Hematology, morphology, cytochemical staining, and ultrastuctural characteristics of blood cells in king cobras (Ophiophagus hannah)
    Chaleow Salakij
    Faculty of Veterinary Medicine, Kasetsart University, Kamphaengsaen Nakorn Pathom, Thailand
    Vet Clin Pathol 31:116-26. 2002
    ..Hematologic tests would be useful for evaluating the health of the snakes, however, basic hematologic data and morphology have not been described for this species...
  93. ncbi Hematology, serum chemistry, and serology of Galápagos penguins (Spheniscus mendiculus) in the Galápagos Islands, Ecuador
    Erika K Travis
    Saint Louis Zoo, One Government Drive, Saint Louis, Missouri 63110, USA
    J Wildl Dis 42:625-32. 2006
    ..Seventy-five of 84 (89%) penguins had antibodies to Chlamydophila psittaci but chlamydial DNA was not detected via polymerase chain reaction in samples from 30 birds...
  94. ncbi Hematologic and plasma biochemical analysis of juvenile head-started northern red-bellied cooters (Pseudemys rubriventris)
    Charles J Innis
    New England Aquarium, Central Wharf, Boston, Massachusetts 02110, USA
    J Zoo Wildl Med 38:425-32. 2007
    ..Basophils were the most numerous type of leucocyte. Results for some values varied significantly between institutions, possibly due to unrecognized differences in husbandry at each facility...
  95. ncbi Hematologic and biochemical reference intervals for Spanish ibex
    Jesús M Pérez
    Departamento de Biologia Animal, Biología Vegetal y Ecología, Universidad de Jaen, Paraje Las Lagunillas, S N, E 23071, Jaen, Spain
    J Wildl Dis 39:209-15. 2003
    ..We found significant differences in eight biochemical parameters among male and female ibexes. Significant differences in values for 20 hematologic and biochemical parameters between age classes also were found...
  96. ncbi Hematologic reference intervals for koi (Cyprinus carpio), including blood cell morphology, cytochemistry, and ultrastructure
    Niraj K Tripathi
    Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA, USA
    Vet Clin Pathol 33:74-83. 2004
    ..Hematologic data are used routinely in the health care of humans and domestic mammals. Similar data for fish are largely fragmentary or have not been collected...
  97. ncbi Hematology, blood chemistry, and bacteriology of the free-ranging Mexican beaded lizard (Heloderma horridum)
    David Espinosa-Avilés
    Zoológico Guadalajara, Avenida Paseo del Zoológico 600, Guadalajara, Jalisco 44390, Mexico
    J Zoo Wildl Med 39:21-7. 2008
    ..This information will serve as baseline reference values for future health assessment studies in conservation, captive breeding, and research programs...
  98. ncbi Hematologic and plasma biochemical values of healthy hybrid tilapia (Oreochromis aureus x Oreochromis nilotica) maintained in a recirculating system
    Michael J Mauel
    Thad Cochran National Warmwater Aquaculture Center, College of Veterinary Medicine, Mississippi State University, P O Box 197, Stoneville, Mississippi 38776, USA
    J Zoo Wildl Med 38:420-4. 2007
    ..The condition of the sample was also noted (lipemic, hemolysis, and icterus). The reference ranges reported in this study can be used in the management of cultured tilapia in recirculating systems...
  99. ncbi Normal haematological values in gyr falcons (Falco rusticolus)
    J H Samour
    Falcon Specialist Hospital and Research Institute, Fahad bin Sultan Falcon Center, PO Box 55, Riyadh 11322, Kingdom of Saudi Arabia
    Vet Rec 157:844-7. 2005
  100. ncbi Successive changes of hematologic characteristics and plasma chemistry values of juvenile loggerhead turtles (Caretta caretta)
    Yuka Kakizoe
    Port of Nagoya Public Aquarium, Minato ku, Nagoya, Aichi, Japan
    J Zoo Wildl Med 38:77-84. 2007
    ..These results were used to establish a hematology and blood chemistry baseline for captive juvenile loggerhead turtles and will aid in their medical management...
  101. ncbi Hematology and plasma biochemistry of captive puna ibis (Plegadis ridgewayi)
    Rob L Coke
    Oklahoma City Zoological Park, 2101 NE 50th Street, Oklahoma City, Oklahoma 73111, USA
    J Wildl Dis 40:141-4. 2004
    ..The values presented here may be useful to clinicians or wildlife managers working with puna ibises...

Research Grants84

  1. NOVEL CONTRACEPTIVES WITH ANTI-HIV ACTIVITY
    OSMOND D CRUZ; Fiscal Year: 2001
    ..The preclinical data on in vivo efficacies of WHI-05 and WHI-07 will be essential to further explore the utility of these novel drugs for clinical studies in human patients. ..
  2. Stampidine: A Novel Broad-Spectrum Anti-HIV Microbicide
    OSMOND D CRUZ; Fiscal Year: 2005
    ..Specific Aims 1 and 2 may provide the foundation for the clinical development of STAMP in Phase II studies as a safe, effective broad-spectrum anti-HIV microbicide without conception-inhibiting functions. ..
  3. Phase II SBIR: WHI-07: A Novel Dual-Function Microbicide
    OSMOND D CRUZ; Fiscal Year: 2005
    ....
  4. Vanadocenes as a New Class of Spermicidal Drugs
    OSMOND D CRUZ; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  5. PHI-443: Novel Non-Spermicidal Anti-HIV Microbicide
    OSMOND D CRUZ; Fiscal Year: 2003
    ..Specific Aims 1 and 2 may provide the foundation for the clinical development of PHI-443 in Phase II studies as a safe, effective broad-spectrum anti-HIV microbicide without conception-inhibiting functions. ..
  6. METVAN: A Novel Anticancer Agent
    OSMOND D CRUZ; Fiscal Year: 2003
    ..The knowledge gained from these studies described under Specific Aims 1-2 is expected to facilitate the design of innovative treatment regimens employing METVAN for metastatic breast cancer and brain tumor patients. ..
  7. FLP-102: Rationally Engineered Antiviral Protein
    OSMOND D CRUZ; Fiscal Year: 2003
    ..The preclinical data on FLP-102 will be essential to further explore the utility of this novel recombinant PAP mutant for Phase II. ..
  8. Prediction of Energy Expenditure/Physical Activity in Children and Adolescents
    Nancy Butte; Fiscal Year: 2008
    ..A new method based on direct ambulatory monitoring of HR and PA will be developed to accurately predict EE, and hence 24-h TEE and AEE in children and adolescents. [unreadable] [unreadable]..
  9. Advances in noninvasive, fluid-less alcohol measurements
    TRENT RIDDER; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  10. GENETICS OF CHILDHOOD OBESITY
    Nancy Butte; Fiscal Year: 2004
    ..This QTL method will be implemented in the program package SOLAR using estimation procedures from FISHER. Lastly, we will test for pleiotropic effects of obesity-related QTLs across phenotypes. ..
  11. Nonalcoholic fatty liver disease in Hispanic obese youth
    Nancy Butte; Fiscal Year: 2005
    ..Newly proposed tests include chromogenic assays to measure lipid peroxidation end products and endotoxins, and ELISA and RIA to measure cytokine and markers of systemic inflammation. ..
  12. Asian Teens, substance dependence and conduct disorder
    Joseph Sakai; Fiscal Year: 2008
    ..abstract_text> ..
  13. Physician Training Program in Neonatal Biology
    John Widness; Fiscal Year: 2007
    ..With NIH support beyond that which the investigators currently enjoy, the investigators will be able to significantly enhance the research training experiences they offer their postdoctoral physician trainees in neonatal medicine. ..
  14. Zinc, Mental Health and School Performance in Mexico
    ARYEH STEIN; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  15. A Novel Vitamin D Target in Human Prostate Cancer
    TOMASZ BEER; Fiscal Year: 2007
    ..New treatment targets are needed to develop new drugs to treat prostate cancer, the most commonly diagnosed cancer and the second-leading cancer killer in US men. [unreadable] [unreadable]..
  16. Interaction of Nutrient & Organochlorine Absorption
    Patrick Tso; Fiscal Year: 2010
    ..The proposed research is important because of the biological and clinical importance of OCs in health and disease and they provide considerable new insights into how OCs are carried and delivered to the various organs in the body. ..
  17. MOLECULAR TOXICOLOGY IN HUMAN KIDNEY CELLS
    Lawrence Lash; Fiscal Year: 2007
    ..Achievement of these aims should build on our previous work in human kidney cells and extend it to provide a much more complete understanding of the various and complex ways in which DCVC affects the human kidney [unreadable] [unreadable]..
  18. Use of Claims Data to Study Quality of Cancer Care
    James Goodwin; Fiscal Year: 2007
    ..We will then explore the reliability of the provider-level data in order to assess its potential utility in assessing quality of care for individual providers. ..
  19. ROLE OF PARATHYROID HORMONE IN RENAL OSTEODYSTROPHY
    Isidro B Salusky; Fiscal Year: 2009
    ..The results of the study should provide new information on the relationship between PTH and bone formation in CKD and they are likely to have important implications for the diagnosis and treatment of renal osteodystrophy. ..
  20. Phase I Clinical Trials of Anti-Cancer Agents
    Francis Giles; Fiscal Year: 2007
    ..abstract_text> ..
  21. Comparative In Vivo Biodistribution of Characterized Manufactured Nanomaterials
    Nancy A Monteiro Riviere; Fiscal Year: 2010
    ..These coordinated studies will provide data to link physical chemical characterizations to in vivo MNM disposition. ..
  22. Nanoliter Lab-on-a-Chip for Rapid Parallel Immunoassays
    Vamsee Pamula; Fiscal Year: 2006
    ..Our eventual goal is to develop a nanoliter, rapid, fully automated, hand-held point-of-analysis/point-of-care analyzer that integrates clinical chemistry, molecular diagnostics, and immunoassays. [unreadable] [unreadable] [unreadable]..
  23. HCV-HIV Coinfection: Impact of Immune Dysfunction
    Richard Sterling; Fiscal Year: 2007
    ..The K-23 award will protect this candidates time and help him mature into a senior investigator in Hepatology. ..
  24. Metabolomics and metabolic compartmentation in the brain
    Julian Griffin; Fiscal Year: 2006
    ..To correlate NMR observable metabolite changes with transcriptional changes. Our data will provide proof-of principle for this methodology, and establish a means for exploring other neurolodegenerative disorders. ..
  25. Genetic basis of myopathy with Paget disease of bone
    Virginia Kimonis; Fiscal Year: 2008
    ..e. effect on ATPase activity, protein-protein interactions, and hexamer formation). Study the VCP specific pathways in C2C12 cell lines (stably transfected wt and R155H VCP) during differentiation and under stress conditions...
  26. Phone Cognitive Behavioral Therapy for Depression after Traumatic Brain Injury
    JESSE FANN; Fiscal Year: 2008
    ..This project will culminate in the design of a trial of CBT-TBI in a large, representative sample of people with TBI and depression. [unreadable] [unreadable] [unreadable]..
  27. BARRIERS TO VOLUNTARY ASSENT IN ASTHMA YOUTH RESEARCH
    JANET BRODY; Fiscal Year: 2008
    ..abstract_text> ..
  28. Genetic Determinants of C-Reactive Protein
    JACQUELINE DANIK; Fiscal Year: 2008
    ..At the end of the proposed research program, Dr. Suk will have attained advanced skills in genetics and epidemiology which can then be applied to independent research in genetic epidemiology and cardiovascular disease. ..
  29. Adrenergic Antagonism During Murine Candidiasis
    Brad Spellberg; Fiscal Year: 2008
    ..For these reasons, the potential for adrenergic antagonism to act as an effective immunotherapy is highly meritorious of investigation in this training application. ..
  30. Long-term prediction of prostate cancer death from kallikreins measured in blood
    Hans Lilja; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  31. Relationship of metabolic abnormalities to hepatic steatosis in HIV
    Richard Sterling; Fiscal Year: 2008
    ..If our hypothesis is correct, this work could result in a dramatic change in the long-term care of the over 1 million HIV infected individuals in the US. [unreadable] [unreadable]..
  32. Novel Machine Learning Methods for Analysis of MALDI-TOF Mass Spectrometry Data
    Habtom Ressom; Fiscal Year: 2008
    ..Furthermore, the peptides represented by the selected candidate biomarkers will be identified. Finally, the performance of the algorithm will be compared with existing methods. [unreadable] [unreadable] [unreadable]..
  33. Resistance and Response Mechanisms to Prostate Cancer Therapy
    TOMASZ BEER; Fiscal Year: 2009
    ..We will test the effectiveness of novel treatments that exploit newly discovered targets in the laboratory and lay the foundation for human trials to develop effective prostate cancer treatment. ..
  34. Interdisciplinary Research Training for Veterinarians
    Lisa Freeman; Fiscal Year: 2008
    ..These evaluations, continued refinement, and the commitment of the program faculty will help to ensure that this becomes a self-sustaining program. ..
  35. Chronic Alcohol & AIDS Impact on Muscle Wasting
    Patricia Molina; Fiscal Year: 2006
    ..abstract_text> ..
  36. BRAZILIAN AIDS PREVENTION TRIALS INTERNATIONAL NETWORK
    Yvonne Bryson; Fiscal Year: 2006
    ..abstract_text> ..
  37. Roles of PTH/PTHrP Receptors in Osteoblastic Cells
    Laura Calvi; Fiscal Year: 2006
    ..abstract_text> ..
  38. TREATMENT PREFERENCE AND VEGETARIAN DIET IN WEIGHT LOSS
    Lora Burke; Fiscal Year: 2005
    ..Additionally, the study will provide information on the role of treatment preference, its effect on behavioral and clinical outcomes, and participants' characteristics by treatment preference. ..
  39. Attention in Children with the 22q11 Deletion Syndrome
    Christina Sobin; Fiscal Year: 2005
    ....
  40. VARIATIONS IN BREAST CANCER TREATMENT AND MORTALITY
    James Goodwin; Fiscal Year: 2002
    ..abstract_text> ..
  41. ANTI-VIRAL TREATMENT OF DEVELOPING BOVINE EMBRYOS
    Maurice Givens; Fiscal Year: 2002
    ....
  42. Acupuncture for hot flashes in prostate cancer patients
    TOMASZ BEER; Fiscal Year: 2004
    ..The overall goal is to provide prostate cancer patients an effective, low toxicity, non-pharmacologic treatment modality for hot flashes. ..
  43. Regulation of maspin in placental development
    ANUJA DOKRAS JAGASIA; Fiscal Year: 2004
    ..In addition, any important new information that may be obtained about the putative role of maspin during embryonic development may help elucidate the biological significance of its loss during tumor progression. ..
  44. The malignant stem cell in multiple myeloma
    Linda Pilarski; Fiscal Year: 2004
    ..This may lead to improvements in therapy and survival for myeloma patients. ..
  45. NOVEL THERAPIES FOR ACETAMINOPHEN TOXICITY
    Laura James; Fiscal Year: 2004
    ..abstract_text> ..
  46. Inhibin/Activin Family in Human Cranifocial Development
    Geralyn Messerlian; Fiscal Year: 2003
    ..abstract_text> ..
  47. CHIMERIC RNA/DNA OLIGONUCLEOTIDE BASED GENE THERAPY
    YEONG HAU LIEN; Fiscal Year: 2003
    ..This preclinical study will provide critical information for future development of optimal gene targeting therapy for treating hereditary renal diseases, such as autosomal dominant polycystic kidney disease. ..
  48. PHEROMONES--IDENTIFICATION/BIOCHEMICAL STUDIES
    Milos Novotny; Fiscal Year: 2001
    ..Understanding the aspects of chemical communication in the species could also be important in a population control of wild rodents. ..
  49. Genital Ulcer Disease and HIV Transmission
    Jeanne Sheffield; Fiscal Year: 2005
    ..The pursuit of these aims will further elucidate the cellular and molecular bases of the interrelationship between GUD and HIV-1 transmission, particularly in women. ..
  50. Cardiac Troponin Testing for Myocardial Infarction
    Fred Apple; Fiscal Year: 2001
    ..abstract_text> ..
  51. PERIODONTAL INFECTION AND RISK FOR MYOCARDIAL INFARCTION
    Robert Genco; Fiscal Year: 2001
    ..Therefore, understanding the association between these two diseases is of significant importance, both to individuals and for public health measures directed to reducing their morbidity and mortality. ..
  52. MODULATION OF INTESTINAL OBESITY SIGNALS
    Patrick Tso; Fiscal Year: 2004
    ..In addition, the apo A-IV knockout and transgenic animals will be used to determine if there is interaction between the lymph glucose and lymph apo A-IV signals. ..
  53. Characterization of Familial Myopathy & Paget Disease
    Virginia Kimonis; Fiscal Year: 2005
    ..Elucidation of the genetic defect will help us understand the pathogenesis of this multifaceted disorder and hopefully result in specific therapy. ..
  54. Evaluation of a Biomarker for Acetaminophen Toxicity
    Laura James; Fiscal Year: 2005
    ..The data generated from this study will lead to enhanced recognition of APAP hepatotoxicity, thus allowing for better identification of "at risk" populations and the creation of prevention strategies. ..
  55. Oregon Prostate Cancer Conference 2001
    TOMASZ BEER; Fiscal Year: 2003
    ....
  56. Roles of CYP1 & 19 in Fundulus Steroids & PAH Metabolism
    Kristine Willett; Fiscal Year: 2009
    ..This research will further define the utility of Fundulus as a model organism for studying PAH-associated toxicities and in the development of human CYP19 or CYP1 B-related therapeutics. ..
  57. GENE CAUSING PAGET & LIMB-GIRDLE MUSCULAR DYSTROPHY
    Virginia Kimonis; Fiscal Year: 2003
    ..Delineation of the genetic component responsible for the LGMD/PDB phenotype should promise similar insight and facilitate in the design of novel treatment protocols for the two disorders. ..
  58. PHI 346: A Novel Dual-Function Microbicide
    OSMOND D CRUZ; Fiscal Year: 2003
    ..Following successful completion of the Phase I in vivo efficacy studies, gel formulation of PHI-346 will be further explored as a vaginal dual-function microbicide in Phase II. ..
  59. FUNCTIONAL IMAGING OF TINNITUS AND HEARING LOSS
    Alan Lockwood; Fiscal Year: 2002
    ..We expect to identify neural systems mediating tinnitus and related phenomena that will lead to the development of rational therapy targeted at affected neural areas. ..
  60. Improving Self-Monitoring in Weight Loss with Technology
    Lora E Burke; Fiscal Year: 2010
    ..Subjects will complete assessments at baseline, 6, 12, 18, and 24 months. This innovative study will provide information on the efficacy of combining technological advances with proven behavioral strategies. ..
  61. Cannabinoid effects on HIV/AIDS
    Patricia E Molina; Fiscal Year: 2010
    ....
  62. Renal Failure in Non-Myeloablative Stem Cell Transplant
    Chirag Parikh; Fiscal Year: 2007
    ..abstract_text> ..
  63. LOS ANGELES PEDIATRIC AIDS CLINICAL TRIALS UNIT
    Yvonne Bryson; Fiscal Year: 2006
    ..The core and developmental laboratories in both virology and immunology have the capability to provide new innovative assays to enhance the overall scientific agenda and support the clinical trials. ..
  64. VITAMIN K AND BONE TURNOVER IN POSTMENOPAUSAL WOMEN
    Neil Binkley; Fiscal Year: 2003
    ..abstract_text> ..
  65. Nanoliter Lab-on-a-chip for Protein Crystallization
    Vamsee Pamula; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  66. Exercise & influenza immunity:Psychoneuroendocrine Model
    Marian Kohut; Fiscal Year: 2004
    ..The findings from this study may have relevance from both a clinical and basic research perspective, if moderate exercise is associated with enhanced anti-influenza immunity and improved protection from infection. ..
  67. Alcoholism and Disease: Immune /Pathological Mechanisms
    Patricia Molina; Fiscal Year: 2002
    ..The proceedings of these symposia will be published and a summary report to the NIAAA will be prepared. ..
  68. UTMB Center for Population Health and Health Disparities
    James Goodwin; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  69. Society for Pediatric & Perinatal Epidemiologic Research
    Anna Maria Siega Riz; Fiscal Year: 2006
    ....
  70. Liquid Chromatography Mass Spectrometry system
    Adrian Franke; Fiscal Year: 2005
    ..abstract_text> ..
  71. Racial disparaties in ESRD: Bone Disease & Morbidity
    Michal Melamed; Fiscal Year: 2005
    ..abstract_text> ..
  72. Androgen deficiency and Osteopenia in Anorexia Nervosa
    Karen Miller; Fiscal Year: 2002
    ..In the third phase of the study, we will examine the effects of administering testosterone on bone density and body mass. ..
  73. Modulation of Oxidative Damage by Tea Polyphenols
    Jia Sheng Wang; Fiscal Year: 2002
    ..The results of this proposed study will help to understand the mechanisms of antioxidative role of tea polyphenols in modulating human hepatocarcinogenesis caused by hepatitis B/C viruses and aflatoxins. ..
  74. Estrogen, Metabolism, Menopause, and Health Outcomes
    MaryFran Sowers; Fiscal Year: 2006
    ..This is a unique opportunity to prospectively integrate lifestyle elements with measures of hormone metabolism pathways into a comprehensive examination of multiple human health effects. ..
  75. Blood-based lipid biomarkers reflective of Alzheimer-associated neurodegeneration
    Michelle Mielke; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  76. Functional Status and the Menopause Transition
    MaryFran R Sowers; Fiscal Year: 2010
    ..Among the elderly, older women live longer, develop more chronic disease and experience more prolonged and severe disability than older men. ..
  77. Outcomes of Sleep Disorders in Older Men-Portland
    Eric Orwoll; Fiscal Year: 2007
    ..We will also supplement the bank of MrOS specimens to allow for testing of future hypotheses concerning the role of sleep in the development of age-related diseases and conditions. ..
  78. Mast Cell-Induced Inflammation in Vascular Disease
    Kottarappat N Dileepan; Fiscal Year: 2010
    ..abstract_text> ..
  79. SWAN Sleep Study II - Michigan Center
    MaryFran Sowers; Fiscal Year: 2008
    ..The results can inform primary prevention of adverse health outcomes due to the menopause-related sleep disturbances. [unreadable] [unreadable] [unreadable]..
  80. Change in Bone, Arthritis, Function: Hormones & Obesity
    MaryFran Sowers; Fiscal Year: 2009
    ....
  81. ORAL AND SKELETAL BONE LOSS IN OLDER MEN
    Eric Orwoll; Fiscal Year: 2006
    ..Since the MrOS cohort is already established through other funds, this request will provide a very cost-effective means for addressing these important oral health issues. ..
  82. Development of blood lipid biomarkers for Alzheimer's disease progression
    Michelle Mielke; Fiscal Year: 2008
    ..A major application would be as a surrogate or secondary outcome measure in clinical trials of emerging therapies for AD. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  83. VIRUS PHOTOINACTIVATION--DIMETHYLMETHYLENE BLUE IN RBC
    Stephen Wagner; Fiscal Year: 2004
    ..abstract_text> ..