laboratory techniques and procedures

Summary

Summary: Methods, procedures, and tests performed in the laboratory with an intended application to the diagnosis of disease or understanding of physiological functioning. The techniques include examination of microbiological, cytological, chemical, and biochemical specimens, normal and pathological.

Top Publications

  1. ncbi Bilirubin proficiency testing using specimens containing unconjugated bilirubin and human serum: results of a College of American Pathologists study
    Stanley F Lo
    Reference Standards Laboratory, Department of Pathology and Laboratory Medicine, Children s Hospital of Wisconsin, Milwaukee 53226, USA
    Arch Pathol Lab Med 128:1219-23. 2004
  2. ncbi Pseudoepidemic of Q fever at an animal research facility
    Lisa A Conti
    Florida Department of Health, Tallahassee, Florida, USA
    Vector Borne Zoonotic Dis 4:343-350. 2004
  3. ncbi Components of quality control
    A A Hurley
    Comprehensive Cytometric Consulting, Ballwin, Missouri, USA
    Curr Protoc Cytom . 2001
  4. pmc Real-time PCR in clinical microbiology: applications for routine laboratory testing
    M J Espy
    Mayo Clinic, 200 First St SW, Hilton 470, Rochester, MN 55905, USA
    Clin Microbiol Rev 19:165-256. 2006
  5. ncbi Management of laboratory test results in family practice. An OKPRN study. Oklahoma Physicians Resource/Research Network
    J W Mold
    Department of Family and Preventive Medicine, University of Oklahoma Health Sciences Center, Oklahoma City 73104, USA
    J Fam Pract 49:709-15. 2000
  6. ncbi Multistate surveillance for laboratory-confirmed, influenza-associated hospitalizations in children: 2003-2004
    Stephanie J Schrag
    National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Pediatr Infect Dis J 25:395-400. 2006
  7. ncbi Investigation of suspected laboratory cross-contamination: interpretation of single smear-negative, positive cultures for Mycobacterium tuberculosis
    V J Cook
    Division of TB Control, British Columbia Centre for Disease Control, Vancouver, Canada
    Clin Microbiol Infect 12:1042-5. 2006
  8. ncbi Survey of physician diagnostic practices for patients with acute diarrhea: clinical and public health implications
    Thomas W Hennessy
    Foodborne and Diarrheal Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Clin Infect Dis 38:S203-11. 2004
  9. ncbi Variation in test ordering behaviour of GPs: professional or context-related factors?
    Wim H J M Verstappen
    Centre for Quality of Care Research, Department of General Practice, Maastricht University, The Netherlands
    Fam Pract 21:387-95. 2004
  10. ncbi Use of diagnostic accuracy as a metric for evaluating laboratory proficiency with microarray assays using mixed-tissue RNA reference samples
    P S Pine
    Center for Drug Evaluation and Research, US FDA, Silver Spring, MD, USA
    Pharmacogenomics 9:1753-63. 2008

Detail Information

Publications255 found, 100 shown here

  1. ncbi Bilirubin proficiency testing using specimens containing unconjugated bilirubin and human serum: results of a College of American Pathologists study
    Stanley F Lo
    Reference Standards Laboratory, Department of Pathology and Laboratory Medicine, Children s Hospital of Wisconsin, Milwaukee 53226, USA
    Arch Pathol Lab Med 128:1219-23. 2004
    ..The composition of the specimens, bovine serum enriched with ditaurobilirubin, was responsible for the erroneous results...
  2. ncbi Pseudoepidemic of Q fever at an animal research facility
    Lisa A Conti
    Florida Department of Health, Tallahassee, Florida, USA
    Vector Borne Zoonotic Dis 4:343-350. 2004
    ..This pseudoepidemic resulted from a lapse in laboratory quality control for testing. Similar errors can be avoided through standardization and improved review of laboratory procedures...
  3. ncbi Components of quality control
    A A Hurley
    Comprehensive Cytometric Consulting, Ballwin, Missouri, USA
    Curr Protoc Cytom . 2001
    ..This unit presents information on the techniques for determining when results are in control or out of control...
  4. pmc Real-time PCR in clinical microbiology: applications for routine laboratory testing
    M J Espy
    Mayo Clinic, 200 First St SW, Hilton 470, Rochester, MN 55905, USA
    Clin Microbiol Rev 19:165-256. 2006
    ..This review focuses on the application of real-time PCR in the clinical microbiology laboratory...
  5. ncbi Management of laboratory test results in family practice. An OKPRN study. Oklahoma Physicians Resource/Research Network
    J W Mold
    Department of Family and Preventive Medicine, University of Oklahoma Health Sciences Center, Oklahoma City 73104, USA
    J Fam Pract 49:709-15. 2000
    ..Ineffective management of laboratory test results can result in suboptimal care and malpractice liability. However, there is little information available on how to do this important task properly in primary care settings...
  6. ncbi Multistate surveillance for laboratory-confirmed, influenza-associated hospitalizations in children: 2003-2004
    Stephanie J Schrag
    National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Pediatr Infect Dis J 25:395-400. 2006
    ..We describe laboratory-confirmed, influenza-associated hospitalizations in a population representing almost 6% of children in the United States...
  7. ncbi Investigation of suspected laboratory cross-contamination: interpretation of single smear-negative, positive cultures for Mycobacterium tuberculosis
    V J Cook
    Division of TB Control, British Columbia Centre for Disease Control, Vancouver, Canada
    Clin Microbiol Infect 12:1042-5. 2006
    ..All single smear-negative, positive cultures processed on the same day as smear-positive specimens should be reviewed on a case-by-case basis to identify possible false-positive cultures...
  8. ncbi Survey of physician diagnostic practices for patients with acute diarrhea: clinical and public health implications
    Thomas W Hennessy
    Foodborne and Diarrheal Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Clin Infect Dis 38:S203-11. 2004
    ..These variabilities suggest a need for clinical diagnostic guidelines for diarrhea. Many physicians could benefit from education to improve their knowledge about tests included in routine stool examinations...
  9. ncbi Variation in test ordering behaviour of GPs: professional or context-related factors?
    Wim H J M Verstappen
    Centre for Quality of Care Research, Department of General Practice, Maastricht University, The Netherlands
    Fam Pract 21:387-95. 2004
    ..The aim of this study was to describe GPs' test ordering behaviour, and to establish professional and context-related determinants of GPs' inclination to order tests...
  10. ncbi Use of diagnostic accuracy as a metric for evaluating laboratory proficiency with microarray assays using mixed-tissue RNA reference samples
    P S Pine
    Center for Drug Evaluation and Research, US FDA, Silver Spring, MD, USA
    Pharmacogenomics 9:1753-63. 2008
    ....
  11. pmc Comparison of the Directigen flu A+B test, the QuickVue influenza test, and clinical case definition to viral culture and reverse transcription-PCR for rapid diagnosis of influenza virus infection
    Annie Ruest
    Department of Microbiology and Infectious Diseases, Faculté de Médecine de l Université de Sherbrooke, Sherbrooke, Quebec, Canada
    J Clin Microbiol 41:3487-93. 2003
    ..RT-PCR detects more cases of influenza than viral culture, and this greater accuracy makes it a more useful reference standard...
  12. ncbi Assessing the impact of the frequency of quality control testing on the quality of reported patient results
    Curtis A Parvin
    Washington University School of Medicine, Department of Pathology and Immunology, Saint Louis, MO 63110, USA
    Clin Chem 54:2049-54. 2008
    ..The probability of rejecting an analytical run, however, is not affected by changes in QC-testing frequency. A different performance measure is necessary to assess the impact of the frequency of QC testing...
  13. pmc Inactivation of cultured Mycobacterium tuberculosis organisms prior to DNA extraction
    Zoheira Djelouagji
    J Clin Microbiol 44:1594-5. 2006
  14. ncbi Evaluation of the performance of randomized versus fixed time schedules for quality control procedures
    Curtis A Parvin
    Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA
    Clin Chem 53:575-80. 2007
    ....
  15. pmc Why public health agencies cannot depend on good laboratory practices as a criterion for selecting data: the case of bisphenol A
    John Peterson Myers
    Environmental Health Sciences, Charlottesville, Virginia 22902, USA
    Environ Health Perspect 117:309-15. 2009
    ....
  16. pmc Harmonization guidelines for HLA-peptide multimer assays derived from results of a large scale international proficiency panel of the Cancer Vaccine Consortium
    Cedrik Michael Britten
    Tumor Immunology Group, Department for Immunohematology and Blood Transfusion, Leiden University Medical Centre, Leiden, The Netherlands
    Cancer Immunol Immunother 58:1701-13. 2009
    ..The Cancer Vaccine Consortium of the Cancer Research Institute (CVC-CRI) conducted a multicenter HLA-peptide multimer proficiency panel (MPP) with a group of 27 laboratories to assess the performance of the assay...
  17. pmc Reporting of measures of accuracy in systematic reviews of diagnostic literature
    Honest Honest
    Academic Dept, of Obstetrics and Gynaecology, Birmingham Women s Hospital, Birmingham B15 2TG, United Kingdom
    BMC Health Serv Res 2:4. 2002
    ..Therefore, we performed this study to assess the measures of accuracy used for reporting results of primary studies as well as their meta-analysis in systematic reviews of test accuracy studies...
  18. ncbi Does this patient have influenza?
    Stephanie A Call
    Department of Medicine, University of Louisville, Louisville, KY 40202, USA
    JAMA 293:987-97. 2005
    ..Making a reliable, rapid clinical diagnosis is essential to appropriate patient management that may be especially important during shortages of antiviral agents caused by high demand...
  19. pmc Results and harmonization guidelines from two large-scale international Elispot proficiency panels conducted by the Cancer Vaccine Consortium (CVC/SVI)
    Sylvia Janetzki
    ZellNet Consulting, Inc, Fort Lee, NJ, USA
    Cancer Immunol Immunother 57:303-15. 2008
    ..These results provide initial harmonization guidelines to optimize Elispot assay performance to the immunotherapy community. Further optimization is in process with ongoing panels...
  20. pmc Understanding laboratory testing in diagnostic uncertainty: a qualitative study in general practice
    Trudy van der Weijden
    Department of General Practice, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Br J Gen Pract 52:974-80. 2002
    ..Better knowledge of the professional's motives for ordering laboratory tests in the case of diagnostic uncertainty may lead to interventions directed at reducing unnecessary testing...
  21. ncbi Sexually transmitted infection/HIV laboratory testing in resource-limited countries: steps to improve use effective testing and to ensure diagnostic capacity
    Elizabeth Donegan
    Department of Anesthesiology, University of California Medical Center, San Francisco, California 94143, USA
    Sex Transm Dis 30:905-8. 2003
  22. ncbi Problems in interpreting laboratory tests. What do unexpected results mean?
    M L Brigden
    Penticton Regional Hospital, BC, Canada
    Postgrad Med 107:145-6, 151-2, 155-8 passim. 2000
    ..More clinical research is needed to establish appropriate reference ranges, especially for those over the age of 75 years...
  23. ncbi The quality of reporting in diagnostic test research: getting better, still not optimal
    Patrick M M Bossuyt
    Clin Chem 50:465-6. 2004
  24. ncbi Investigation of Laboratory cross-contamination of Mycobacterium tuberculosis cultures
    L Fitzpatrick
    Division of Tuberculosis Elimination, National Center for HIV, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Clin Infect Dis 38:e52-4. 2004
    ..Failure to recognize laboratory cross-contamination with M. tuberculosis leads to both erroneous administration of unnecessary medications and expenditure of resources required to conduct contact investigations...
  25. ncbi The truth about quality: medical usefulness and analytical reliability of laboratory tests
    James O Westgard
    Department of Pathology and Laboratory Medicine, University of Wisconsin Medical School, 1300 University Avenue, Madison, WI 53706, USA
    Clin Chim Acta 346:3-11. 2004
    ..It is commonly thought that laboratory tests provide two-thirds to three-fourths of the information used for making medical decisions. If so, test results had better tell the truth about what is happening with our patients...
  26. ncbi [Domestic and international trends concerning allowable limits of error in external quality assessment scheme]
    Shigemi Hosogaya
    Clinical Laboratory, University of Yamanashi Hospital, Nakakoma gun, Yamanashi pref 409 3898
    Rinsho Byori 53:547-53. 2005
    ..When expressed in coefficient of variation terms, these allowable limits may be applied at a wide range of levels of quantity...
  27. ncbi Fetal-maternal hemorrhage detection in Ontario
    John D Lafferty
    Hamilton Regional Laboratory Medicine Program, Hamilton
    Am J Clin Pathol 119:72-7. 2003
    ....
  28. ncbi Quality performance of newborn screening systems: strategies for improvement
    D Webster
    NZ National Testing Centre, PO Box 872, Auckland, New Zealand
    J Inherit Metab Dis 30:576-84. 2007
    ..Outside the laboratory, standards, education and protocols improve the quality of specimen collection, diagnosis and treatment, which together produce the health gains...
  29. ncbi Regulatory processes and three Rs alternatives
    J Milstien
    Department of Vaccines and Biologicals, World Health Organization, Geneva, Switzerland
    Dev Biol (Basel) 111:15-9. 2002
    ..Thus, regulation of biological products in future will probably see a replacement, reduction and refinement (the 3 Rs) of animal testing...
  30. ncbi [The pediatrician, his laboratory and its uncertainty]
    Olivier Boulat
    Laboratoire Central de Chimie Clinique, Département de Médecine de Laboratoire, Centre Hospitalier Universitaire Vaudois 1011 Lausanne
    Rev Med Suisse Romande 122:645-8. 2002
    ....
  31. ncbi Thailand intensive external quality assessment schemes as dynamic tools for improving laboratory quality and standard
    Amarin Prijavudhi
    Department of Clinical Chemistry, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand
    Southeast Asian J Trop Med Public Health 33:14-7. 2002
    ..Regular EQA newsletters, and yearly summer-time seminar and training prove to be the essential education tools promoting both laboratory quality and standard intensively...
  32. ncbi Standardization of gamma-glutamyltransferase assays by intermethod calibration. Effect on determining common reference limits
    Josiane Steinmetz
    Laboratoire de Biologie Clinique, Centre de Medecine Preventive, Vandoeuvre les Nancy, France
    Clin Chem Lab Med 45:1373-80. 2007
    ..We evaluated if this harmonization could lead to reference limits common to different routine methods...
  33. ncbi Integration of data derived from biological variation into the quality management system
    Carmen Ricos
    Analytical Quality Commission, Spanish Society of Clinical Biochemistry And Molecular Pathology, Spain
    Clin Chim Acta 346:13-8. 2004
    ..corrected] Data on within- and between-subject biological variation are available for around 250 analytes commonly used in medical laboratories...
  34. ncbi Guidelines for blood smear preparation and staining procedure for setting up an external quality assessment scheme for blood smear interpretation. Part I: Control material
    Juan Lluis Vives Corrons
    Red Cell Pathology Unit, ICMHO IDIPAPS, Hospital Clinic i Provincial, Barcelona, Spain
    Clin Chem Lab Med 42:922-6. 2004
    ..Due to a lack of guidance documents, many organizers are reluctant to offer a hematology scheme. This article aims to be a very practical guidance document for external quality assessment organizers for the set up of blood smear schemes...
  35. ncbi Flow cytometric lymphocyte subset enumeration: 10 years of external quality assessment in the Benelux countries
    Wilfried H B M Levering
    Laboratory for Histocompatibility and Immunogenetics, Sanquin Blood Bank South West Region, Rotterdam, The Netherlands
    Cytometry B Clin Cytom 74:79-90. 2008
    ..Failure to fully standardize protocols may have led to only modest reductions in variability of results between laboratories...
  36. ncbi Evaluation of serum protein profiling by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry for the detection of prostate cancer: I. Assessment of platform reproducibility
    O John Semmes
    Department of Microbiology and Molecular Cell Biology, Virginia Prostate Center, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Clin Chem 51:102-12. 2005
    ..This report describes the first stage of a National Cancer Institute/Early Detection Research Network-sponsored multiinstitutional evaluation and validation of this approach for detection of prostate cancer...
  37. ncbi Against the proposition: for the diagnosis of viral infections, commercial assays provide more reliable results than do in-house assays
    Vivienne James
    Quality Assurance Laboratory, Health Protection Agency Centre for Infections, 61 Colindale Avenue, London NW9 5EQ, UK
    Rev Med Virol 18:77-80. 2008
    ..The EQA results described here support my supposition that, for the diagnosis of viral infections, commercial assays do not provide more reliable results than do in-house assays...
  38. ncbi Statistical diagnostics emerging from external quality control of real-time PCR
    E Marubini
    Institute of Medical Statistics and Biometry, Universita degli Studi di Milano, Milan, Italy
    Int J Biol Markers 19:141-6. 2004
    ..Our findings suggest the usefulness of the approach presented here for monitoring the heterogeneity of results produced by different laboratories and for selecting those laboratories that need technical advice on their performance...
  39. ncbi Mistakes encountered during external quality assessment schemes (EQAS): illustrated and categorized examples
    Mathias Maitrejean
    Clin Lab 53:483-4. 2007
  40. ncbi An Italian program of External Quality Control for chromogranin A (CgA) assay: performance evaluation of CgA determination
    Paolo Verderio
    Unit of Medical Statistics and Biometry, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Clin Chem Lab Med 45:1244-50. 2007
    ..This paper reports the results regarding laboratory performance...
  41. ncbi Estimates of measurement uncertainty from proficiency testing schemes, internal laboratory quality monitoring and during routine enforcement examination of foods
    B Jarvis
    Ross Biosciences Ltd, Upton Bishop, Ross on Wye, UK
    J Appl Microbiol 103:462-7. 2007
    ....
  42. ncbi The external quality assessment schemes in Thailand
    Nisarat Opartkiattikul
    Department of Clinical Pathology, Mahidol University, Bangkok, Thailand
    Rinsho Byori 50:121-5. 2002
    ..g. coagulation, serology for autoimmune disease and hemoglobin typing. External quality assessment programs for these laboratories are urgently needed...
  43. ncbi External quality assessment scheme and laboratory accreditation in Indonesia
    Ina S Timan
    Clinical Pathology Department, Faculty of Medicine, University of Indonesia Cipto Mangunkusumo Hospital, Jakarta, Indonesia
    Rinsho Byori 50:126-30. 2002
    ..This accreditation program is still in progress for all public and private hospital laboratories...
  44. ncbi Quality assurance/quality control of foot and mouth disease solid phase competition enzyme-linked immunosorbent assay--Part II. Quality control: comparison of two charting methods to monitor assay performance
    N Goris
    Department of Virology, Veterinary and Agrochemical Research Centre, Groeslenberg 99, 1180 Brussels, Belgium
    Rev Sci Tech 24:1005-16. 2005
    ..Both chart types are equally sensitive to shifts, but the EWMA method seems to provide the best balance between false rejection and false acceptance...
  45. ncbi The quality of laboratory testing today: an assessment of sigma metrics for analytic quality using performance data from proficiency testing surveys and the CLIA criteria for acceptable performance
    James O Westgard
    Department of Pathology and Laboratory Medicine, University of Wisconsin Medical School, Madison 53706, USA
    Am J Clin Pathol 125:343-54. 2006
    ..9 to 2.6; and PSA (TEa = 10%), 1.2 to 1.8. The analytic quality of laboratory tests requires improvement in measurement performance and more intensive quality control monitoring than the CLIA minimum of 2 levels per day...
  46. ncbi The performance of quantitative D-dimer assays in laboratory routine
    Michael Spannagl
    INSTAND e V, Dusseldorf, Germany
    Blood Coagul Fibrinolysis 16:439-43. 2005
    ..In conclusion, standardization or at least harmonization of D-dimer assays is necessary to ensure comparability of D-dimer plasma levels measured in clinical routine...
  47. ncbi Toward implementation of a regional quality assurance program in cytopathology: the Hong Kong experience
    Wai Kuen Ng
    Cytology Quality Assurance Program Working Group, Hong Kong College of Pathologists, China
    Acta Cytol 50:164-77. 2006
    ..To develop a local quality assurance program in cytopathology based on circulation of patient specimens on glass slides, with limited resources...
  48. ncbi An external quality assessment program for von Willebrand factor laboratory analysis: an overview from the European concerted action on thrombosis and disabilities foundation
    Piet Meijer
    European Concerted Action on Thrombosis and Disabilities ECAT Foundation, Leiden, The Netherlands
    Semin Thromb Hemost 32:485-91. 2006
    ..It can be concluded that further improvement in the laboratory diagnosis of vWD is necessary...
  49. ncbi Laboratory tests for measurement of von Willebrand factor show poor agreement among different centers: results from the United Kingdom National External Quality Assessment Scheme for Blood Coagulation
    Steve Kitchen
    United Kingdom National External Quality Assessment Scheme NEQAS for Blood Coagulation, Sheffield, United Kingdom
    Semin Thromb Hemost 32:492-8. 2006
    ..Overall, our data show that laboratory testing for vWD remains problematic. It remains to be seen whether newer techniques will offer consistently improved precision...
  50. ncbi [Attending physician must consider uncertainty. Don't let yourself be cheated by the numbers!]
    Anders Kallner
    Karolinska Universitetslaboratoriet, Karolinska Universitetssjuk huset Solna
    Lakartidningen 103:2467-9. 2006
  51. pmc External quality assessment of molecular typing of Staphylococcus aureus isolates by a network of laboratories
    A Deplano
    Laboratoire de Référence MRSA Staphylocoques, Universite Libre de Bruxelles, Service de Microbiologie, Hopital Erasme, 808, Route de Lennik, 1070 Brussels, Belgium
    J Clin Microbiol 44:3236-44. 2006
    ..Our findings indicate that surveys of lab proficiency are useful for validation and optimization of molecular typing services to local hospital infection control programs...
  52. ncbi Repeated HIV-1 resistance genotyping external quality assessments improve virology laboratory performance
    Diane Descamps
    Laboratoire de Virologie, CHU Bichat Claude Bernard, Paris, France
    J Med Virol 78:153-60. 2006
    ..077). No errors were made by 19% of laboratories in 2002, compared to 42% in 2003. These results show the value of repeated external quality assessments...
  53. ncbi The Lebanese External Quality Assessment Scheme for laboratories: was it worth establishing?
    Ghassan Hallak
    LEQAS, Laboratoires St Elie, Centre Michel Aboujaoudé, Antelias, Lebanon
    J Med Liban 53:9-15. 2005
    ....
  54. ncbi A simple statistical approach for assessing inter-laboratory comparison tests for classical swine fever diagnosis
    K R Depner
    Federal Research Centre for Virus Diseases of Animals, Boddenblick 5a, 17498 Insel Riems Greifswald, Germany
    J Vet Med B Infect Dis Vet Public Health 53:473-6. 2006
    ..The final analysis of the data showed that the CSF diagnostic quality improved continuously...
  55. ncbi EC intercomparisons for laboratories monitoring environmental radioactivity
    U Wätjen
    EC JRC, Institute for Reference Materials and Measurements IRMM, Retieseweg 111, B 2440 Geel, Belgium
    Appl Radiat Isot 64:1108-13. 2006
    ..The treatment of an individual result, deviating widely from the reference value, is discussed. Monte-Carlo simulations allow to estimate the maximum errors possibly made due to a non-suitable measurement geometry...
  56. ncbi External quality assessment scheme for hemostasis in India
    Joy Mammen
    Department of Clinical Pathology and Blood Bank, Christian Medical College, Vellore, India
    Semin Thromb Hemost 33:265-72. 2007
    ..The challenges ahead are to increase participation, improve reporting of results, and provide individualized support to laboratories to improve performance when necessary...
  57. ncbi External quality assessment and the laboratory diagnosis of thrombophilia
    Piet Meijer
    ECAT Foundation, Leiden, The Netherlands
    Semin Thromb Hemost 31:59-65. 2005
    ..58 x total biological variation). This study shows that a more stable performance of laboratory tests involved in the screening of thrombophilia over a prolonged period of time is necessary...
  58. ncbi Japanese collaborative study to assess inter-laboratory variation in factor VII activity assays
    O Takamiya
    Department of Biomedical Laboratory Sciences, School of Health Sciences, Shinshu University, Matsumoto, Japan
    J Thromb Haemost 5:1686-92. 2007
    ..Despite its importance, there are no data on the variability of inter-laboratory determinations of low to very low plasma FVII activity (FVII:C)...
  59. ncbi Has compliance with CLIA requirements really improved quality in US clinical laboratories?
    Sharon S Ehrmeyer
    Departments of Pathology and Laboratory Medicine, University of Wisconsin Medical School, Room 6175, 1300 University Avenue, Madison, WI 53706, USA
    Clin Chim Acta 346:37-43. 2004
    ....
  60. pmc Institute for quality in laboratory medicine series--controversies in laboratory medicine: nursing and the laboratory: relationship issues that affect quality care
    Anthony Kurec
    University Pathologists Laboratory at State University, New York Upstate Medical University, Syracuse, New York, USA
    MedGenMed 8:52. 2006
  61. ncbi Hematology external quality assessment in Europe
    Josep M Jou
    Servei Hemoteràpia i Hemostàsia, Hospital Clinic, Barcelona, Spain
    Lab Hematol 10:151-2. 2004
  62. ncbi External hematology quality assurance initiative in Asia. Asian Quality Assurance Survey (AQuAS)Program
    Kap No Lee
    Department of Laboratory Medicine, College of Medicine, Korea University, Seoul, Korea
    Lab Hematol 10:152-7. 2004
  63. ncbi Saving laboratory records: what, how, how long?
    Dan Baer
    Department of Pathology and Laboratory Medicine, Oregon Health and Science University, Portland, OR, USA
    MLO Med Lab Obs 36:10-1, 14-6; quiz 18-20. 2004
  64. pmc Hemoglobin A1c measurements over nearly two decades: sustaining comparable values throughout the Diabetes Control and Complications Trial and the Epidemiology of Diabetes Interventions and Complications study
    Michael Steffes
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55454, USA
    Clin Chem 51:753-8. 2005
    ..Clinical trials require assays that provide consistent results during the course of a study. The hemoglobin A1c (HbA1c) assay, a measure of chronic glycemia, is critical to the study of diabetes control and complications...
  65. ncbi Pilot external quality assessment survey for post-market vigilance of in vitro diagnostic medical devices and investigation of trueness of participants' results
    Linda M Thienpont
    Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Ghent University, Gent, Belgium
    Clin Chem Lab Med 41:183-6. 2003
    ..The survey pointed out to the other participants, interchanging instrument, reagent and calibrator, that they are themselves responsible for the problems shown and hence also for problem-solving...
  66. ncbi On the interpretation of affirmative follow-up tests in immunoassays: what must not be done?
    Adel A A Ismail
    Tanglewood, Chevet Lane, Wakefield, West Yorkshire, WF2 6HL, UK
    Ann Clin Biochem 43:249-51. 2006
    ..Though commendable practice, these extra tests could in some cases lead to a false sense of assurance, misleading clinicians and wasting resources. I would like to highlight the use and misuse of these tests...
  67. ncbi Assessment of physical conditions and current practice in laboratories carrying out sputum smear microscopy in Northwest Ethiopia
    Andargachew Mulu
    Department of Microbiology and Parasitology, University of Gondar, PO Box 196, Gondar, Ethiopia
    Trop Doct 35:215-7. 2005
    ..Laboratory safety standards need to be improved, to minimize the risk of infection. In addition, there is an urgent need for education, training and supervision of the staff involved in sputum microscopy...
  68. ncbi [Procedure for accurate evaluation of laboratory data and its international trends]
    Katsuhiko Kuwa
    Graduate School of Comprehensive Human Sciences Institute of Clinical Medicine, University of Tsukuba, Tsukuba, 305 8575
    Rinsho Byori 53:531-9. 2005
    ..As the results, the work of the standardization based on reliability such as validation of reagent's kits and the measured values and uncertainty evaluation would be internationally advanced...
  69. ncbi Method comparison in the clinical laboratory
    Asger Lundorff Jensen
    Department of Small Animal Clinical Science, The Royal Veterinary and Agricultural University, Groennegaardsvej 3, DK 1870, Frederiksberg C, Denmark
    Vet Clin Pathol 35:276-86. 2006
    ..Finally, a protocol for comparing simpler semiquantitative methods with established methods that measure on a continuous scale is suggested...
  70. ncbi Effects of clinical laboratory choice on study outcome: an interlaboratory evaluation of aminotransferase levels
    Jody L Green
    Research Department, Denver Health Rocky Mountain Poison and Drug Center, Denver, CO, USA
    Pharmacotherapy 28:453-7. 2008
    ..To determine if laboratories with disparate alanine aminotransferase (ALT) reference ranges would report different rates of elevation greater than the upper limit of reference range (ULRR) and thus have the potential to alter study results...
  71. ncbi Use of proficiency samples to assess diagnostic laboratories in France performing a Trichinella digestion assay
    Isabelle Vallee
    AFSSA, INRA, ENVA, UPVM, UMR956 BIPAR, F 94 706 Maisons Alfort, France
    J Food Prot 70:1685-90. 2007
    ..This study supports the use of proficiency samples to accurately evaluate the performance of routine diagnostic laboratories that conduct digestion tests for animal trichinellosis diagnosis...
  72. ncbi Multilaboratory testing of thrombophilia: current and past practice in Australasia as assessed through the Royal College of Pathologists of Australasia Quality Assurance Program for Hematology
    Emmanuel J Favaloro
    Haematology Laboratories, Institute of Clinical Pathology and Medical Research ICPMR, Westmead Hospital, New South Wales, Australia
    Semin Thromb Hemost 31:49-58. 2005
    ..e., false-normal interpretations for deficient plasma or false-abnormal interpretations for normal plasma). The CVs for these assays ranged from 5 to 40%, with highest CVs typically obtained with PS assays...
  73. ncbi Towards single screening tests for brucellosis
    K Nielsen
    Animal Diseases Research Institute, Canadian Food Inspection Agency, 3851 Fallowfield Rd, Nepean, Ontario, K2H 8P9, Canada
    Rev Sci Tech 24:1027-37. 2005
    ..2%) than from only the OPS, and considerably higher (12.6%) than the CORE. Overall, both the I-ELISA and the FPA with combined antigens were suitable as screening tests for all species of Brucella in the animal species tested...
  74. ncbi Harmonisation of European tests for serological diagnosis of Brucella infection in bovines
    J A McGiven
    OIE FAO WHO Collaborating Centre for Reference and Research on Brucellosis, Department of Bacterial Diseases, Veterinary Laboratories Agency, Woodham Lane, New Haw, Weybridge, Surrey, KT15 3NB, United Kingdom
    Rev Sci Tech 25:1039-53. 2006
    ..The increase in the number of participants in these trials over time reflected the enlargement of the EU and increased the need for quality assurance...
  75. ncbi Mis-identification of factor inhibitors by diagnostic haemostasis laboratories: recognition of pitfalls and elucidation of strategies. A follow up to a large multicentre evaluation
    Emmanuel J Favaloro
    Department of Haematology and Royal College of Pathologists of Australasia Quality Assurance Program, Institute of Clinical Pathology and Medical Research, Westmead Hospital, New South Wales 2145, Australia
    Pathology 39:504-11. 2007
    ....
  76. ncbi Are external quality assurance (EQA) slide schemes a valid tool for the performance assessment of histopathologists?
    D M Parham
    Histopathology, Royal Bournemouth Hospital, Castle Lane East, Bournemouth, Dorset, England BH7 7DW, UK
    Pathol Res Pract 201:117-21. 2005
    ..This paper discusses how these schemes have evolved, the problems of standard setting and their validity as a measure of pathologists performance...
  77. ncbi Discordance rate, a new concept for combining diagnostic decisions with analytical performance characteristics. 1. Application in method or sample system comparisons and in defining decision limits
    Rainer Haeckel
    Institute for Laboratory Medicine, Zentralkrankenhaus Sankt Juergen Strasse, Bremen, Germany
    Clin Chem Lab Med 41:347-55. 2003
    ..It extends the concept of (un)efficiency by including the effect of variability about a decision limit and the distribution of the measurement values in the patient population...
  78. ncbi Evaluation of commutability of control materials
    Emmanuel Brion
    Laboratoire de biochimie appliquée, UFR des Sciences Pharmaceutiques, Universite Louis Pasteur de Strasbourg, Ilkirch, France
    Clin Chem Lab Med 40:625-30. 2002
    ..We propose to verify the commutability of materials before their use in an external quality control assessement...
  79. ncbi Fit-for-purpose shellfish reference materials for internal and external quality control in the analysis of phycotoxins
    Philipp Hess
    Marine Institute, Rinville, Oranmore, Co Galway, Ireland
    Anal Bioanal Chem 387:2463-74. 2007
    ..The intricate link between reference material characterisation and method performance is outlined to give guidance on the appropriate in-house method validation in the rapidly developing field of phycotoxins...
  80. ncbi The Taskforce 2000 survey on medical education in sleep and sleep disorders
    R Rosen
    Comprehensive Sleep Disorders Center, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, USA
    Sleep 21:235-8. 1998
    ..A large majority of respondents indicated their willingness to be involved in sleep education for physicians, and rated this a high priority for the professional organization...
  81. ncbi Physician education in sleep and sleep disorders: a national survey of U.S. medical schools
    R C Rosen
    Comprehensive Sleep Disorders Center, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway 08854
    Sleep 16:249-54. 1993
    ..Overall, it appears that physician education in sleep and sleep disorders is largely inadequate, despite increasing evidence of the role of sleep in patient health and well-being...
  82. pmc Prevalence and antimicrobial susceptibility pattern of methicillin resistant Staphylococcus aureus isolates from Trinidad & Tobago
    Patrick Eberechi Akpaka
    Department of Paraclinical Sciences, Faculty of Medical Sciences, The University of the West Indies, St, Augustine, Trinidad and Tobago
    Ann Clin Microbiol Antimicrob 5:16. 2006
    ..We therefore sought to document comprehensively the prevalence and antimicrobial susceptibility pattern of MRSA isolates in Trinidad and Tobago...
  83. ncbi Current clinical and laboratory practice for the investigation of the antiphospholipid syndrome: findings from the 2008 Australasian antiphospholipid antibody survey
    Emmanuel J Favaloro
    Department of Haematology, Institute of Clinical Pathology and Medical Research ICPMR, Westmead Hospital, New South Wales, Australia
    Pathology 41:666-75. 2009
    ..Depending on their clinical presentation, affected individuals might be seen by a variety of clinical specialties including general physicians and general practionners, with a potentially wide variation in the aPL assays requested...
  84. ncbi Evaluation of vaginal complaints
    Matthew R Anderson
    Department of Family and Social Medicine, Albert Einstein College of Medicine, Bronx, NY, USA
    JAMA 291:1368-79. 2004
    ..Clinicians have traditionally diagnosed vaginal candidiasis, bacterial vaginosis, and vaginal trichomoniasis using some combination of physical examination, pH, the wet mount, and the whiff test...
  85. ncbi The place of molecular genetic methods in the diagnostics of human pathogenic anaerobic bacteria. A minireview
    Elisabeth Nagy
    Institute of Clinical Microbiology, Faculty of Medicine, University of Szeged, Somogyi Béla tér 1, H 6725 Szeged, Hungary
    Acta Microbiol Immunol Hung 53:183-94. 2006
    ..The investigation of toxin production at a molecular level helps in the detection of new toxin types. This mini-review surveys some of the results obtained by our group and others using molecular genetic methods in anaerobic diagnostics...
  86. ncbi Administrative claims analysis of all-cause annual costs of care and resource utilization by age category for ulcerative colitis patients
    Stephen J Bickston
    University of Virginia Health System, Charlottesville, VA 22908, USA
    J Manag Care Pharm 14:352-62. 2008
    ..There is little information in the published literature evaluating the all-cause health care costs of patients with UC according to age...
  87. ncbi Multicentre study on factors determining differences in rate of spread of HIV in sub-Saharan Africa: methods and prevalence of HIV infection
    A Buve
    Department of Microbiology, Institute of Tropical Medicine, Antwerp, Belgium
    AIDS 15:S5-14. 2001
    ....
  88. ncbi Multiscale variation-aware techniques for high-performance digital microfluidic lab-on-a-chip component placement
    Chen Liao
    Department of Electrical and Computer Engineering, Michigan Technological University, Houghton, MI 49931, USA
    IEEE Trans Nanobioscience 10:51-8. 2011
    ..9% reduction in completion time. When considering variations, the variation-unaware design has the average yield of 2%, while our variation-aware technique always satisfies the yield constraint with only 7.7% completion time increase...
  89. ncbi Costing of services of Vietnamese hospitals: identifying costs in one central, two provincial and two district hospitals using a standard methodology
    Steffen Flessa
    Department of Tropical Hygiene and Public Health, University of Heidelberg, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany
    Int J Health Plann Manage 19:63-77. 2004
    ..However, the majority of inhabitants strongly depends on governmental hospital services. These services are currently going through a financial crisis. This demands the quest for efficiency and the wise allocation of public funds...
  90. ncbi 201 SUPPRESSION OF Suz12 IN BOVINE PREIMPLANTATION EMBRYOS VIA CYTOPLASMIC SMALL INTERFERING RNA INJECTION
    G L Williamson
    Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX, USA
    Reprod Fertil Dev 23:200. 2011
    ..Future experiments will explore potential alterations in histone methylation, as well as other epigenetic modifiers in bovine preimplantation embryos, to further elucidate the role of the epigenome in early embryonic development...
  91. ncbi Vaginitis: diagnosis and management
    Martin Quan
    David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Postgrad Med 122:117-27. 2010
    ..Bacterial vaginosis, which has been linked to important gynecologic and pregnancy complications, can be treated with an available oral or topical agent containing either a nitroimidazole or clindamycin...
  92. ncbi Epidemic of jungle yellow fever in Brazil, 2000: implications of climatic alterations in disease spread
    P F Vasconcelos
    WHO Collaborating Center for Arbovirus Reference and Research, Seção de Arbovírus do Instituto Evandro Chagas, Fundação Nacional de Saúde FUNASA, Ministério da Saúde MS, 66090 000, Belem, PA, Brazil
    J Med Virol 65:598-604. 2001
    ..It is noteworthy that the last reported autochthonous cases of sylvatic yellow fever in São Paulo and Bahia, both states outside the endemic/enzootic area, had occurred in 1953 and 1948, respectively...
  93. ncbi Covariate selection in multivariate spatial analysis of ovine parasitic infection
    V Musella
    Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, Italy
    Prev Vet Med 99:69-77. 2011
    ..This research showed the utility of appropriate GIS-driven surveillance systems. Moreover, spatial features can be used to tailor sampling design where the sampling fraction can be a function of remote sensing covariables...
  94. ncbi Eosinophil granule proteins in the assessment of airway inflammation in pediatric bronchial asthma
    O D Wolthers
    Children s Clinic Randers, Randers, Denmark
    Pediatr Allergy Immunol 14:248-54. 2003
    ..In the future, perhaps, a combination of products of inflammatory cells may give more clinically relevant information with respect to prediction, diagnosis, monitoring and outcome of childhood asthma...
  95. ncbi An analysis of human pathogens found in horse/mule manure along the John Muir Trail in Kings Canyon and Sequoia and Yosemite National Parks
    Robert Wayne Derlet
    Emergency Department, University of California, Davis, Medical Center, Sacramento 95817, USA
    Wilderness Environ Med 13:113-8. 2002
    ..To determine the prevalence of microorganisms that are potentially pathogenic for humans in horse/mule manure along the John Muir Trail (JMT)...
  96. pmc Differentiation of Burkholderia species by PCR-restriction fragment length polymorphism analysis of the 16S rRNA gene and application to cystic fibrosis isolates
    C Segonds
    Laboratoire de bactériologie virologie hygiène, CHU Rangueil, 31403 Toulouse Cedex 4, France
    J Clin Microbiol 37:2201-8. 1999
    ....
  97. ncbi Airway interventions in the cardiac electrophysiology laboratory: a retrospective review
    Terrence L Trentman
    Department of Anesthesiology, Mayo Clinic, Phoenix, AZ 85054, USA
    J Cardiothorac Vasc Anesth 23:841-5. 2009
    ..To quantify the incidence of airway interventions during cardiac electrophysiology laboratory procedures...
  98. ncbi Laboratory testing for the antiphospholipid syndrome: making sense of antiphospholipid antibody assays
    Emmanuel J Favaloro
    Department of Haematology, Institute of Clinical Pathology and Medical Research ICPMR, Westmead Hospital, NSW, Australia
    Clin Chem Lab Med 49:447-61. 2011
    ....
  99. ncbi The effect of adding a stone base on the accuracy of working casts using different types of dental stone
    Khalid Al-Abidi
    College of Dentistry at King Faisal University in Dammam, Saudi Arabia
    J Contemp Dent Pract 7:17-28. 2006
    ..The aim of this study was to determine the effect on the dimensional accuracy of a working cast of adding a stone base using different stone products...
  100. ncbi Melioidosis in a rural community of Western Province, Papua New Guinea
    J M Warner
    Microbiology and Immunology, School of Veterinary and Biomedical Sciences, James Cook University, Townsville, Qld 4811, Australia
    Trans R Soc Trop Med Hyg 101:809-13. 2007
    ..Further studies are needed to ascertain the local epidemiology and why children appear particularly at risk, as well as to establish the true extent of melioidosis in Papua New Guinea...
  101. ncbi The dental student as a technician: preclinical and clinical laboratory programs in fixed prosthodontics
    V C Petropoulos
    Department of Restorative Dentistry, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104 6003, USA
    J Prosthodont 10:164-9. 2001
    ..The purpose of the second part of the survey was to ascertain the delegation of laboratory procedures in preclinical and clinical fixed prosthodontic programs...

Research Grants62

  1. North Carolina Birth Defects Study To Evaluate Pregnancy Exposures (NC BD-STEPS)
    Andrew Olshan; Fiscal Year: 2013
    ..By including multiple study sites, BD-STEPS will aim for a study population that is representative of the US population in racial/ethnic composition. The project period is anticipated to be 8/1/2013 - 7/31/2018. ..
  2. Annual Estimates of Influenza Vaccine Effectiveness: Davidson County, TN
    Marie R Griffin; Fiscal Year: 2010
    ....
  3. Rapid, Near-Transfusion Test for Bacteria in Platelet Units
    ANDREW E LEVIN; Fiscal Year: 2011
    ..This project is aimed at development of a rapid and sensitive test for bacterial contamination which can be performed shortly before transfusion, improving the safety of the U.S. blood supply. ..
  4. The Incidence and Etiology of Influenza-Associated Community-Acquired Pneumonia i
    KATHRYN MARGARET EDWARDS; Fiscal Year: 2013
    ..abstract_text> ..
  5. Longitudinal Aging Biomarker Study in India (LASI-Biomarkers)
    Jinkook Lee; Fiscal Year: 2012
    ....
  6. Home-Based Lithium Level Testing for Bipolar Patients
    KUMAR SUBRAMANIAN; Fiscal Year: 2009
    ..v^^*7 ..
  7. The Health Burden of A Recently Discovered Borrelia Spirochete
    PETER JAMES KRAUSE; Fiscal Year: 2012
    ..miyamotoi infection. ..
  8. Polymorphisms Related to Dopamine Receptor Function and Smoking
    ERIC CHRISTIAN DONNY; Fiscal Year: 2010
    ....
  9. Natural History of AIDS Homosexual Men
    Roger Detels; Fiscal Year: 2013
    ..Thus, the MACS provides an irreplaceable resource for continued study of the natural history of treated and untreated HIV infection and AIDS. ..
  10. Rapid detection of diagnostic chemokines
    Kevin W Plaxco; Fiscal Year: 2013
    ....
  11. Human Monoclonal Antibody To Treat P. aeruginosa Infections in Cystic Fibrosis
    ERIC JOHN PATZER; Fiscal Year: 2013
    ..Incorporating feedback from the FDA, we will then file an IND application. ..
  12. Medications Development for Cannabis-Use Disorders: Clinical Studies
    JOSHUA ANTHONY LILE; Fiscal Year: 2013
    ..The career development activities supported by the K02 award will allow me to sustain and expand these efforts, and thus meet my career goals, which will directly impact the field of cannabis-use treatment. ..
  13. Prenatal Cytogenetic Diagnosis by Array-based copy number Analysis
    Ronald Wapner; Fiscal Year: 2011
    ..Approximately 2.5 years are allotted for patient recruitment and laboratory processing;with an additional 2.5 years for pregnancy outcome and infant follow-up in selected cases, as well as data processing. ..
  14. Agonist Replacement Therapy for Methamphetamine Dependence: Human Lab Studies
    Craig R Rush; Fiscal Year: 2013
    ....
  15. Development of a lab-on-a-chip for point-of-care biomonitoring of blood metals
    Ian Papautsky; Fiscal Year: 2013
    ..Collaboration with our commercialization partner will position the multi-metal sensor for wide-spread use in clinical and research settings. ..
  16. Nanotube Antibody Arrays for Profiling Circulating Diseased Cells
    Balaji Panchapakesan; Fiscal Year: 2011
    ..Based on the sensor arrays, a device will be developed that will be used in detecting and profiling circulating breast cancer cells in blood. This new technology will be compared against standard immunoassays such as ELISA. ..
  17. Sustained release depot pre-exposure prophylaxis in breast feeding populations
    Thomas Smith; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  18. CLINICAL PREDICTORS FOR SUCCESSFUL VISUAL REHABILITATION
    FRANKLIN PORTER; Fiscal Year: 1992
    ..A predictive formula based on simple measurements in the low vision clinic will assist the clinician in prescribing telescopic spectacles and will improve rehabilitation strategies...
  19. Agonist Replacement Therapy for Cocaine Dependence: Identifying Novel Medications
    CRAIG RUSH; Fiscal Year: 2009
    ..Identifying novel agonist replacement therapies is important because clinicians may be reluctant to use d-amphetamine because of its abuse potential. ..
  20. NOVEL METHOD TO MEASURE GLOMERULAR FILTRATION RATE
    Mary Rusckowski; Fiscal Year: 2000
    ..proposed commercial application: not available ..
  21. Virtuality Reality Cue Exposure for Crack Cocaine
    Barbara Rothbaum; Fiscal Year: 2003
    ..The long-term objectives to be achieved in Phase II include the development and testing of the treatment of crack cocaine dependence using VR cue exposure therapy in a controlled design. ..
  22. Protective Immune Responses in HIV-1 Exposed Infants
    Carey Farquhar; Fiscal Year: 2006
    ..Kreiss and John, will prepare her for the complex data analysis required by this study and contribute substantially to the development of her career as an independent clinical investigator. ..
  23. A PROGRAMMABLE LIGHT SOURCE FOR MICROFLUIDIC DEVICES
    MARKUS HEHLEN; Fiscal Year: 1999
    ..PROPOSED COMMERCIAL APPLICATION: The proposed commercial application is a compact, programmable light source for microfluidic devices/instruments. ..
  24. Metallic Nanosensor Matrix with Enhanced Fluorescence
    HENRY SZMACINSKI; Fiscal Year: 2003
    ..abstract_text> ..
  25. Mechanisms for Preterm Birth in African-American Women
    Susan Gennaro; Fiscal Year: 2004
    ....
  26. GENERAL CLINICAL RESEARCH CENTER
    Raymond Fonseca; Fiscal Year: 1990
    ....
  27. Predicting Relative Workload During Physical Work
    TARIQ ABDELHAMID; Fiscal Year: 2003
    ..abstract_text> ..
  28. Laboratory evaluations of a common behavioral treatment
    Timothy Vollmer; Fiscal Year: 2002
    ..In addition, the studies could lead directly to better application of response-independent treatment schedules. ..
  29. Impulsivity at Different Stages of Adolescent Smoking
    Brady Reynolds; Fiscal Year: 2007
    ..The possible role of impulsive behavior as a mediator between negative life events and cigarette-smoking status among adolescents will be explored. [unreadable] [unreadable] [unreadable]..
  30. BEHAVIORAL VULNERABILITY TO EARLY SMOKING RELAPSE
    Richard Brown; Fiscal Year: 2001
    ..abstract_text> ..
  31. MEASUREMENT OF GROWTH AND SECRETION OF SINGLE CELLS
    James Weaver; Fiscal Year: 1993
    ....
  32. AGGRESSIVE BEHAVIOR--ALCOHOL AND MENSTRUAL CYCLE EFFECTS
    Donald Dougherty; Fiscal Year: 1999
    ..This information will identify factors in the relationship between alcohol and violence -- particularly as they relate to females. ..
  33. Comprehensive non-invasive prenatal diagnostics
    Eugene Pergament; Fiscal Year: 2004
    ..abstract_text> ..
  34. NIMH-COR Honors High School Research Education Grant
    Pamela Banks; Fiscal Year: 2005
    ....
  35. Alcohol and the Activation of Aggressive Thoughts
    Brian Quigley; Fiscal Year: 2006
    ..The training and research will be conducted at the Research Institute on Addictions, an environment which has a strong history of supporting the development of young researchers. ..
  36. Labscape: Languages and Tools for Cell Biology
    LAWRENCE ARNSTEIN; Fiscal Year: 2002
    ..The concepts and tools will be disseminated through publication and software distribution where appropriate. As progress is made, participation in standards bodies might also be warranted. ..
  37. LABORATORY MODEL OF ESCAPE--MOTIVATED ABERRANT BEHAVIOR
    Michael Perone; Fiscal Year: 2001
    ..abstract_text> ..
  38. SCOR IN PATHOBIOLOGY OF LUNG DEVELOPMENT
    ALBERT COLLIER; Fiscal Year: 2001
    ..These Cores will function to centralize equipment, reagents and various laboratory procedures to facilitate the research efforts of the SCOR investigators. ..
  39. CALIFORNIA STATE UNIVERSITY, HAYWARD BRIDGE PROGRAM
    DONALD GAILEY; Fiscal Year: 2000
    ..The Consortium has built-in mechanisms for tracking of student progress, for both formative and summative program evaluation, and for interlinkage with other science-education and research-based programs in the Bay Area. ..
  40. Labscape: Languages and Tools for Cell Biology
    LAWRENCE ARNSTEIN; Fiscal Year: 2005
    ..The concepts and tools will be disseminated through publication and software distribution where appropriate. As progress is made, participation in standards bodies might also be warranted. ..
  41. TRAINING IN MOLECULAR VIROLOGY AND SIV PATHOBIOLOGY
    Anita Trichel; Fiscal Year: 2001
    ..The institution is committed to the training of basic science researchers, as well as clinicians. ..
  42. PREFACULTY TRAINING IN PEDIATRIC NEPHROLOGY
    Clifford Kashtan; Fiscal Year: 2009
    ..The program remains deeply committed to the development of academic pediatric nephrologists, who continue to be in short supply throughout the nation, and to the preparation of women and minorities for these positions ..
  43. DRUG USE AND LABORATORY MEASURES OF RATIONAL CHOICE
    GENE HEYMAN; Fiscal Year: 1999
    ..The studies will also test whether individuals can be taught to make better decisions. These data will be used to design a curriculum for teaching decision making. ..
  44. LABORATORY ANIMAL DIAGNOSTIC RESOURCE
    C Lang; Fiscal Year: 1992
    ..Continuation is deemed essential to the institution's biomedical research program...
  45. MARIJUANA EFFECTS ON BASIC BEHAVIORAL MECHANISMS
    SCOTT LANE; Fiscal Year: 2004
    ..Collectively, these studies are designed to help elucidate the effects of marijuana on basic learning mechanisms, and the role of marijuana in the etiology of socially detrimental behavior. ..
  46. Clinical Decision Rule to Identify Children with Intra-Abdominal Injuries
    James Holmes; Fiscal Year: 2008
    ..unreadable]..
  47. Diabetes and Drug-Associated Hyperkalemia: Effect of Laboratory Monitoring
    Marsha Raebel; Fiscal Year: 2008
    ..The findings will also assist in developing a framework for future studies to evaluate the effects and costs of medication-laboratory monitoring among patients with diabetes. [unreadable] [unreadable] [unreadable] [unreadable]..
  48. Community-Based Participatory Approach to Farmworker Housing, Exposures & Health
    Thomas A Arcury; Fiscal Year: 2010
    ....
  49. Preservation of Embryonic Stem Cells in Desiccated State
    Mehmet Toner; Fiscal Year: 2007
    ..In Specific Aim 4, we will investigate the stability of dried mouse ES cells and optimize the desiccation and rehydration conditions most conducive to the differentiation of dry preserved mouse ES cells into hepatocytes. ..
  50. Evaluation of Vitamin D Requirements During Pregnancy
    Bruce Hollis; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  51. Appropriate Pneumococcal Vaccination in Infants in Fiji
    Fiona Russell; Fiscal Year: 2007
    ..The results of this study will form the basis of an effectiveness evaluation following the pilot introduction of pneumococcal immunization into Fiji in 3-5 years time. [unreadable] [unreadable]..
  52. CALMODULIN IN NEOPLASTIC TRANSFORMATION OF BREAST TISSUE
    David Sacks; Fiscal Year: 2008
    ..The long-term goal of this program is the development of novel and specifically targeted pharmacologic agents for the treatment of carcinoma. ..
  53. BIOLOGY AND IMMUNOLOGY OF MALARIA PARASITE LIVER-STAGES
    Abdu Azad; Fiscal Year: 2005
    ..falciparum EE-stages. Finally, we will define the contribution of P. yoelii liver-stage gene products in protective immunity via DNA immunizations. ..
  54. COLUMBIA-ADARC-CORNELL AIDS CLINICAL TRIALS UNIT
    Scott Hammer; Fiscal Year: 2006
    ..Thus, the Columbia-ADARC ACTU will be an active participant in the Group's mission to improve the health of HIV infected individuals and set standards for treatment of HIV disease. ..
  55. Pilot Study of Adrenal hormones
    Joanne Dorgan; Fiscal Year: 2004
    ..Intraclass correlation coefficients will be calculated to evaluate whether hormone measurements in a single aliquot reflect longer term levels. ..
  56. COST EFFECTIVENESS OF GENETIC SCREENING FOR COLON CANCER
    Scott Ramsey; Fiscal Year: 2002
    ....
  57. PAIN AND ANALGESIC RESPONSE--SEX AND HORMONE VARIATIONS
    Sandra Comer; Fiscal Year: 2002
    ..In addition, they will more carefully examine sex differences in analgesic response to butorphanol and morphine, two agonists with differing selectivities for mu and kappa opioid receptors. ..
  58. INTRACELLULAR CATIONS AND EXCITOTOXICITY
    Ian Reynolds; Fiscal Year: 2002
    ....
  59. Resilience and Health in Communities and Individuals.
    Alex Zautra; Fiscal Year: 2009
    ..For those mid-aged adults with children, the outcome measures will also be assessed in one their children approaching adult life (aged 16 to 24 years;N = 160) to probe the transmission of resilience across generations. ..
  60. Osteoporosis and Bone Augmentation/Implant Outcomes: An Observational Study
    Martin A Freilich; Fiscal Year: 2010
    ..This application represents an important step in this ongoing research initiative. ..
  61. Race, Ethnicity and Quality of Health Care for Newborns
    Laurence Baker; Fiscal Year: 2005
    ..Our work will focus on Black-White differences, disparities for Hispanics (including subgroups like Mexican and Puerto Rican), and disparities for Asian and Pacific Islanders. ..
  62. PREVENTION OF VASCULOPATHY AND NEPHROPATHY IN METABOLIC SYNDROME
    Michael S Goligorsky; Fiscal Year: 2010
    ..abstract_text> ..