incidental findings

Summary

Summary: Unanticipated information discovered in the course of testing or medical care. Used in discussions of information that may have social or psychological consequences, such as when it is learned that a child's biological father is someone other than the putative father, or that a person tested for one disease or disorder has, or is at risk for, something else.

Top Publications

  1. pmc ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing
    Robert C Green
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Genet Med 15:565-74. 2013
  2. pmc Managing incidental findings and research results in genomic research involving biobanks and archived data sets
    Susan M Wolf
    University of Minnesota, Minneapolis, Minnesota, USA
    Genet Med 14:361-84. 2012
  3. pmc Managing incidental findings in human subjects research: analysis and recommendations
    Susan M Wolf
    University of Minnesota, MN, USA
    J Law Med Ethics 36:219-48, 211. 2008
  4. ncbi International normative perspectives on the return of individual research results and incidental findings in genomic biobanks
    Ma n H Zawati
    Faculty of Medicine, Human Genetics Department, McGill University, Montreal, Quebec, Canada
    Genet Med 14:484-9. 2012
  5. pmc Secondary variants in individuals undergoing exome sequencing: screening of 572 individuals identifies high-penetrance mutations in cancer-susceptibility genes
    Jennifer J Johnston
    Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Hum Genet 91:97-108. 2012
  6. pmc The law of incidental findings in human subjects research: establishing researchers' duties
    Susan M Wolf
    University of Minnesota, MN, USA
    J Law Med Ethics 36:361-83, 214. 2008
  7. pmc Perspectives of clinical genetics professionals toward genome sequencing and incidental findings: a survey study
    A A Lemke
    School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA
    Clin Genet 84:230-6. 2013
  8. pmc Incidental findings on brain magnetic resonance imaging: systematic review and meta-analysis
    Zoe Morris
    Division of Clinical Neurosciences, Western General Hospital, Edinburgh
    BMJ 339:b3016. 2009
  9. pmc Disclosure of incidental findings from next-generation sequencing in pediatric genomic research
    Ruqayyah Abdul-Karim
    Department of Bioethics, Clinical Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 1156, USA
    Pediatrics 131:564-71. 2013
  10. pmc Exploring concordance and discordance for return of incidental findings from clinical sequencing
    Robert C Green
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Genet Med 14:405-10. 2012

Detail Information

Publications280 found, 100 shown here

  1. pmc ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing
    Robert C Green
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Genet Med 15:565-74. 2013
    ..The ACMG appointed a Working Group on Incidental Findings in Clinical Exome and Genome Sequencing to make recommendations about responsible management of incidental ..
  2. pmc Managing incidental findings and research results in genomic research involving biobanks and archived data sets
    Susan M Wolf
    University of Minnesota, Minneapolis, Minnesota, USA
    Genet Med 14:361-84. 2012
    ..Unresolved, however, is what responsibilities biobanks should shoulder to manage incidental findings and individual research results of potential health, reproductive, or personal importance to individual ..
  3. pmc Managing incidental findings in human subjects research: analysis and recommendations
    Susan M Wolf
    University of Minnesota, MN, USA
    J Law Med Ethics 36:219-48, 211. 2008
    No consensus yet exists on how to handle incidental findings (IFs) in human subjects research...
  4. ncbi International normative perspectives on the return of individual research results and incidental findings in genomic biobanks
    Ma n H Zawati
    Faculty of Medicine, Human Genetics Department, McGill University, Montreal, Quebec, Canada
    Genet Med 14:484-9. 2012
    ..one topic is emerging as the focus of ongoing debate: the return of individual research results and incidental findings to participants...
  5. pmc Secondary variants in individuals undergoing exome sequencing: screening of 572 individuals identifies high-penetrance mutations in cancer-susceptibility genes
    Jennifer J Johnston
    Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Hum Genet 91:97-108. 2012
    ....
  6. pmc The law of incidental findings in human subjects research: establishing researchers' duties
    Susan M Wolf
    University of Minnesota, MN, USA
    J Law Med Ethics 36:361-83, 214. 2008
    Research technologies can now produce so much information that there is significant potential for incidental findings (IFs). These are findings generated in research that are beyond the aims of the study...
  7. pmc Perspectives of clinical genetics professionals toward genome sequencing and incidental findings: a survey study
    A A Lemke
    School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA
    Clin Genet 84:230-6. 2013
    The introduction of clinical genome-wide sequencing raises complex issues regarding the management of incidental findings. However, there is a lack of empirical studies assessing views of providers involved in potential disclosure of ..
  8. pmc Incidental findings on brain magnetic resonance imaging: systematic review and meta-analysis
    Zoe Morris
    Division of Clinical Neurosciences, Western General Hospital, Edinburgh
    BMJ 339:b3016. 2009
    To quantify the prevalence of incidental findings on magnetic resonance imaging (MRI) of the brain.
  9. pmc Disclosure of incidental findings from next-generation sequencing in pediatric genomic research
    Ruqayyah Abdul-Karim
    Department of Bioethics, Clinical Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 1156, USA
    Pediatrics 131:564-71. 2013
    ..Although researchers and ethicists have raised theoretical concerns about incidental findings in the context of genetic research, next-generation sequencing will make this once largely hypothetical ..
  10. pmc Exploring concordance and discordance for return of incidental findings from clinical sequencing
    Robert C Green
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Genet Med 14:405-10. 2012
    The aim of this study was to explore specific conditions and types of genetic variants that specialists in genetics recommend should be returned as incidental findings in clinical sequencing.
  11. pmc Actionable, pathogenic incidental findings in 1,000 participants' exomes
    Michael O Dorschner
    Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA
    Am J Hum Genet 93:631-40. 2013
    The incorporation of genomics into medicine is stimulating interest on the return of incidental findings (IFs) from exome and genome sequencing...
  12. ncbi The prevalence of clinically relevant incidental findings on chest computed tomographic angiograms ordered to diagnose pulmonary embolism
    William B Hall
    Division of Pulmonary and Critical Care Medicine, University of North Carolina at Chapel Hill, Campus Box 7020, 130 Mason Farm Rd, Chapel Hill, NC 27514
    Arch Intern Med 169:1961-5. 2009
    ..Our objective was to determine the prevalence and management implications of incidental findings on chest CTAs ordered to assess for PE.
  13. ncbi The incidental upper gastrointestinal subepithelial mass
    Joo Ha Hwang
    Division of Gastroenterology, University of Washington, Seattle, Washington 98195, USA
    Gastroenterology 126:301-7. 2004
  14. pmc Incidental findings in pediatric research
    Benjamin S Wilfond
    Treuman Katz Center for Pediatric Bioethics at Seattle Children s Hospital, WA, USA
    J Law Med Ethics 36:332-40, 213. 2008
    ..b>Incidental findings with clear and proximate clinical importance should be disclosed to both...
  15. ncbi Incidental findings in the maxillofacial area with 3-dimensional cone-beam imaging
    Jung Yul Cha
    Department of Orthodontics, Dental Hospital, College of Dentistry, Yonsei University, Seoul, Korea
    Am J Orthod Dentofacial Orthop 132:7-14. 2007
    The purposes of this study were to evaluate the location, nature, and occurrence of incidental findings in maxillofacial structures on 3-dimensional cone-beam volumetric scans done for dental diagnostic purposes and to look for ..
  16. ncbi Incidental adrenal lesions: principles, techniques, and algorithms for imaging characterization
    Giles W L Boland
    Department of Radiology, Massachusetts General Hospital, White Building 270C, 55 Fruit St, Boston, MA 02114, USA
    Radiology 249:756-75. 2008
    ..An imaging algorithm is provided to guide radiologists toward the appropriate test to make the correct diagnosis...
  17. ncbi Physiology and pathophysiology of incidental findings detected on FDG-PET scintigraphy
    Yiyan Liu
    Nuclear Medicine Section, Department of Radiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA
    Semin Nucl Med 40:294-315. 2010
    ..Understanding the physiology and pathophysiology of normal FDG distribution and common incidental findings is therefore essential to the physician interpreting whole-body FDG-PET/CT studies...
  18. ncbi Perspectives of Canadian researchers on ethics review of neuroimaging research
    C Deslauriers
    Neuroethics Research Unit, Institut de Recherches Cliniques de Montreal, Quebec, Canada
    J Empir Res Hum Res Ethics 5:49-66. 2010
    ..dealt with adequately, well, and even very well by research ethics boards (REBs), but some issues such as incidental findings and transfer of knowledge were problematic...
  19. pmc Ethics. Incidental findings in brain imaging research
    Judy Illes
    Center for Biomedical Ethics, Stanford University, Palo Alto, CA 94304, USA
    Science 311:783-4. 2006
  20. ncbi Prevalence of incidental findings in computed tomographic screening of the chest: a systematic review
    Peter C A Jacobs
    Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands
    J Comput Assist Tomogr 32:214-21. 2008
    To perform a systematic review on the prevalence of incidental findings in computed tomographic (CT) screening studies of the chest.
  21. ncbi Systematic review: prevalence of malignant incidental thyroid nodules identified on fluorine-18 fluorodeoxyglucose positron emission tomography
    Philip Shie
    Diagnostic Imaging Services, Kaiser Permanente Fontana Medical Center, Fontana, California, USA
    Nucl Med Commun 30:742-8. 2009
    ..To review current literature and determine the prevalence of malignant incidental focal hypermetabolic thyroid lesions detected by fluorine-18 fluorodeoxyglucose positron emission tomography (F-FDG-PET)...
  22. ncbi Smooth or attached solid indeterminate nodules detected at baseline CT screening in the NELSON study: cancer risk during 1 year of follow-up
    Dong Ming Xu
    Department of Radiology, University Medical Center Groningen, Hanzeplein 1, Postbus 30 001, 9700 RB Groningen, The Netherlands
    Radiology 250:264-72. 2009
    ....
  23. ncbi Benign retroperitoneal schwannoma: a case series and review of the literature
    Siamak Daneshmand
    Department of Urology, University of Southern California Keck School of Medicine, Los Angeles, California, USA
    Urology 62:993-7. 2003
    ..To present our experience with four retroperitoneal schwannomas treated by surgical excision and review the current literature. Retroperitoneal schwannomas are rare, benign tumors and infrequently present to the urologist...
  24. ncbi AME position statement on adrenal incidentaloma
    M Terzolo
    Medicine I, AOU San Luigi Gonzaga, University of Turin, Regione Gonzole 10, Orbassano 10043, Italy
    Eur J Endocrinol 164:851-70. 2011
    ..To assess currently available evidence on adrenal incidentaloma and provide recommendations for clinical practice...
  25. pmc A practical approach to incidental findings in neuroimaging research
    J M Shoemaker
    MIND Research Network, Albuquerque, NM, USA
    Neurology 77:2123-7. 2011
    We describe the systematic approach to incidental findings (IFs) used at the Mind Research Network (MRN) where all MRI scans receive neuroradiologist interpretation and participants are provided results.
  26. ncbi Incidental findings of the lumbar spine at MRI during herniated intervertebral disk disease evaluation
    Hee Jin Park
    Department of Radiology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Pyung Dong, Jongno gu, Seoul, South Korea
    AJR Am J Roentgenol 196:1151-5. 2011
    The objective of our study was to evaluate the frequency and types of incidental findings of the lumbar spine during MR evaluation for herniated intervertebral disk disease.
  27. pmc Taxonomizing, sizing, and overcoming the incidentalome
    Isaac S Kohane
    Children s Hospital Informatics Program, Children s Hospital, Boston, Massachusetts, USA
    Genet Med 14:399-404. 2012
    With the advent of whole-genome sequencing made clinically available, the number of incidental findings is likely to rise. The false-positive incidental findings are of particular clinical concern...
  28. ncbi Adrenal incidentalomas: risk of adrenocortical carcinoma and clinical outcomes
    Christine J O'Neill
    University of Sydney Endocrine Surgical Unit, St Leonards, New South Wales, Australia
    J Surg Oncol 102:450-3. 2010
    ..The aim of this study is to determine the risk of malignancy in patients undergoing surgery for adrenal incidentaloma; and to compare clinical outcomes in those with adrenocortical carcinoma (ACC) based on the mode of presentation...
  29. ncbi From incidentaloma to adrenocortical carcinoma: the surgical management of adrenal tumors
    Wen T Shen
    Department of Surgery, University of California, San Francisco, California, USA
    J Surg Oncol 89:186-92. 2005
    ..We also discuss the choice of optimal surgical approach for performing adrenalectomy (laparoscopic, open, hand-assist)...
  30. pmc Researcher perspectives on disclosure of incidental findings in genetic research
    Meredith C Meacham
    University of Washington s Institute of Public Health Genetics Master of Public Health program, Seattle, WA 98195 7120, USA
    J Empir Res Hum Res Ethics 5:31-41. 2010
    ..Researchers' decision-making processes about whether to disclose incidental findings were governed by potentially conflicting duties in three primary domains: information quality, adherence to ..
  31. ncbi Cervical vertebrae anomalies-incidental findings on lateral cephalograms
    Priyavrat Soni
    Division of Orthodontics, Department of Dental Surgery, Armed Forces Medical College, Pune, India
    Angle Orthod 78:176-80. 2008
    Three cases of abnormal incidental findings on lateral cephalogram are presented. These patients reported for orthodontic consultation in their adolescence...
  32. ncbi Communication of results and disclosure of incidental findings in longitudinal paediatric research
    Velizara Anastasova
    INSERM, UMR1027, Epidemiology and analyses in Public Health, Toulouse, France
    Pediatr Allergy Immunol 24:389-94. 2013
    ..High-throughput biological explorations reveal also incidental findings of medical relevance...
  33. ncbi Psychosocial consequences and severity of disclosed incidental findings from whole-body MRI in a general population study
    Carsten Oliver Schmidt
    Study of Health in Pomerania KEF, University Medicine of Greifswald, Institute for Community Medicine, Walther Rathenau Str 48, 17475 Greifswald, Germany
    Eur Radiol 23:1343-51. 2013
    ..Little is known about the psychosocial impact and subjective interpretation of communicated incide ntal findings from whole-body magnetic resonance imaging (wb-MRI). This was addressed with this general population study...
  34. ncbi Potentially relevant incidental findings on research whole-body MRI in the general adult population: frequencies and management
    Katrin Hegenscheid
    Department of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Ferdinand Sauerbruch Str 1, 17475 Greifswald, Germany
    Eur Radiol 23:816-26. 2013
    To report the frequencies of potentially relevant incidental findings in the general adult population and to develop a protocol for their management in whole-body magnetic resonance imaging (wb-MRI).
  35. ncbi Picture archiving and communication system: effect on reporting of incidental findings
    Steven C Wagner
    Department of Radiology, Thomas Jefferson University Hospital, 3390 Gibbon Bldg, 111 S 11th St, Philadelphia, PA 19107, USA
    Radiology 225:500-5. 2002
    To determine the effect of a picture archiving and communication system (PACS) on reporting of incidental findings outside the area of interest, with a focus on lumbar spinal magnetic resonance (MR) imaging.
  36. pmc Population studies: return of research results and incidental findings Policy Statement
    Bartha Maria Knoppers
    Public Population Project in Genomics and Society P G, Montreal, Quebec, Canada
    Eur J Hum Genet 21:245-7. 2013
    ..delineate the particular characteristics of population studies, (2) distinguish the circumstances surrounding access by researchers to such studies, and (3) develop a framework for the return of research results and incidental findings.
  37. ncbi Limited value of adrenal biopsy in the evaluation of adrenal neoplasm: a decade of experience
    Peter J Mazzaglia
    Rhode Island Hospital, Warren Alpert School of Medicine, Brown University, Providence, RI 02906, USA
    Arch Surg 144:465-70. 2009
    ..To determine the value of percutaneous adrenal biopsy in the evaluation of adrenal neoplasm...
  38. pmc Do researchers have an obligation to actively look for genetic incidental findings?
    Catherine Gliwa
    National Institutes of Health, Bethesda, MD, USA
    Am J Bioeth 13:32-42. 2013
    ..genetic sequencing has prompted debate about the responsibilities of researchers toward genetic incidental findings. Assuming there is a duty to disclose significant incidental findings, might there be an obligation for ..
  39. pmc Recommendations for returning genomic incidental findings? We need to talk!
    Wylie Burke
    Department of Bioethics and Humanities, University of Washington, Seattle, Washington, USA
    Genet Med 15:854-9. 2013
    The American College of Medical Genetics and Genomics recently issued recommendations for reporting incidental findings from clinical whole-genome sequencing and whole-exome sequencing...
  40. ncbi Extracardiac findings at cardiac CT: a practical approach
    David Sosnouski
    Department of Radiology, Medical University of South Carolina, Charleston, SC 29425, USA
    J Thorac Imaging 22:77-85. 2007
    ..It is important to have a practical approach in detecting and evaluating incidental findings so as not to cause undue cost or patient anxiety, while ensuring timely management of critical diseases.
  41. ncbi Thyroid incidentalomas: to treat or not to treat
    N G Iyer
    Head and Neck Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Eur Arch Otorhinolaryngol 267:1019-26. 2010
    ..We propose a pragmatic algorithm when faced with this clinical dilemma under differing circumstances...
  42. ncbi Incidental findings are frequent in young healthy individuals undergoing magnetic resonance imaging in brain research imaging studies: a prospective single-center study
    Gesa Hartwigsen
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    J Comput Assist Tomogr 34:596-600. 2010
    There is an ongoing debate about how to handle incidental findings (IF) detected in healthy individuals who participate in research-driven magnetic resonance imaging (MRI) studies...
  43. ncbi Managing incidental findings on abdominal CT: white paper of the ACR incidental findings committee
    Lincoln L Berland
    Department of Radiology, University of Alabama, Birmingham, AL, USA
    J Am Coll Radiol 7:754-73. 2010
    ..care and as CT image quality has improved, there has been an increase in the frequency of detecting "incidental findings," defined as findings that are unrelated to the clinical indication for the imaging examination performed...
  44. ncbi Bad news about bad news: the disclosure of risks to insurability in research consent processes
    Victoria Smith Apold
    Faculties of Law and Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Account Res 18:31-44. 2011
    One of the phenomena associated with research is "incidental findings," that is, unexpected findings made during the research, and outside the scope of the research, which have potential health importance...
  45. ncbi The American College of Radiology strategy for managing incidental findings on abdominal computed tomography
    Lincoln L Berland
    Department of Radiology, University of Alabama at Birmingham, 619 South 19th Street, N348, Birmingham, AL 35249, USA
    Radiol Clin North Am 49:237-43. 2011
    There has been a dramatically increased awareness of the substantial clinical challenges posed by incidental findings found on cross-sectional imaging...
  46. ncbi Incidental findings arising with cone beam computed tomography imaging of the orthodontic patient
    Sheelagh A Rogers
    Orthodontic Department, University Dental Hospital, Cardiff, Wales, UK
    Angle Orthod 81:350-5. 2011
    ..This article reports on four incidental findings-that appear unrelated to the scan's original purpose-arising in patients for whom CBCT was carried out for ..
  47. pmc Pathological and incidental findings on brain MRI in a single-center study of 229 consecutive girls with early or precocious puberty
    Signe Sloth Mogensen
    Department of Growth and Reproduction, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 7:e29829. 2012
    ..With the recent decline in age at pubertal onset among US and European girls, it has been suggested that only girls with CPP below 6 years of age should have brain MRI performed...
  48. pmc Management of incidental findings during imaging research in "healthy" volunteers: current UK practice
    T C Booth
    Department of Biochemistry, University of Cambridge, Cambridge, UK
    Br J Radiol 85:11-21. 2012
    b>Incidental findings (IF) are becoming increasingly common due to the proliferation of imaging research. IFs can be life-changing for "healthy" volunteers...
  49. ncbi Incidental venous thromboembolism in ambulatory cancer patients receiving chemotherapy
    Marcello Di Nisio
    Department of Medicine and Aging, Centre for Aging Sciences, University GD AnnunzioFoundation, Chieti, Italy
    Thromb Haemost 104:1049-54. 2010
    ..Further research is needed to understand the natural history of incidental thrombosis in order to develop adequate management guidelines...
  50. ncbi Detection of incidental breast tumors by noncontrast spiral computed tomography of the chest
    Hiroko Shojaku
    Department of Radiology, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Radiat Med 26:362-7. 2008
    ..The aim of this study was to investigate the frequency of breast tumors and breast cancers with noncontrast spiral chest computed tomography (CT)...
  51. pmc The incidence and outcome of incidental breast lesions detected by computed tomography
    A Hussain
    Breast Unit, Department of General Surgery, Princess Royal University Hospital, Farnborough Common, Kent, UK
    Ann R Coll Surg Engl 92:124-6. 2010
    ..The aim of this study was to investigate the incidence and outcomes of breast lesions detected incidentally on CT scans...
  52. ncbi Chest CT screening of asbestos-exposed workers: lung lesions and incidental findings
    T Vierikko
    Department of Diagnostic Radiology, Tampere University Hospital, Tampere, Finland
    Eur Respir J 29:78-84. 2007
    ..Two lung cancers were stage Ia and were radically operated. In total, 277 individuals presented 343 incidental findings of which 46 required further examination. Four of these were regarded as clinically important...
  53. pmc Subjects' expectations in neuroimaging research
    Matthew P Kirschen
    Stanford Center for Biomedical Ethics, Stanford University School of Medicine, Stanford, California 94304 5748, USA
    J Magn Reson Imaging 23:205-9. 2006
    To explore subjects' attitudes and expectations concerning the detection and management of incidental findings in neuroimaging research.
  54. ncbi Clinically significant incidental findings on the unenhanced CT portion of PET/CT studies: frequency in 250 patients
    Medhat M Osman
    Division of Nuclear Medicine, Department of Internal Medicine, St Louis University, St Louis, Missouri, USA
    J Nucl Med 46:1352-5. 2005
    ..current study was to evaluate the incremental added value and frequency of potentially clinically significant incidental findings from the independent reading of the unenhanced CT portion of PET/CT studies by an expert CT radiologist.
  55. ncbi Incidental lesions found on CT colonography: their nature and frequency
    T Xiong
    Department of Public Health and Epidemiology, Public Health Building, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Br J Radiol 78:22-9. 2005
    ..While only a small population were judged "important", the prevalence of serious lesions outside the colon was nevertheless higher than in many other screening programs...
  56. ncbi Potential clinical and economic consequences of noncardiac incidental findings on cardiac computed tomography
    Jimmy Machaalany
    Department of Medicine Cardiology, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario, Canada
    J Am Coll Cardiol 54:1533-41. 2009
    We sought to determine the incidence, clinical significance, and potential financial impact of noncardiac incidental findings (IF) identified with cardiac computed tomography (CT).
  57. ncbi Prevalence of significant extracoronary findings on multislice CT coronary angiography examinations and coronary artery calcium scoring examinations
    Y M Law
    Department of Diagnostic Radiology, Singapore General Hospital, Singapore
    J Med Imaging Radiat Oncol 52:49-56. 2008
    ..The prevalence of extracoronary findings on these examinations may be of significance, resulting in additional 'hidden costs' if widespread 'screening' is adopted...
  58. ncbi Incidental findings on brain MRI in the general population
    Meike W Vernooij
    Department of Epidemiology and Biostatistics, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    N Engl J Med 357:1821-8. 2007
    ..We conducted a study to determine the prevalence of such incidental brain findings in the general population...
  59. ncbi The prevalence and significance of incidental thyroid nodules identified on computed tomography
    Dae Young Yoon
    Department of Radiology, Kangdong Seong Sim Hospital, Hallym University College of Medicine, Seoul, Republic of Korea
    J Comput Assist Tomogr 32:810-5. 2008
    ..The purpose of this study was to assess the prevalence of incidental thyroid nodules (ITN) found on computed tomography (CT) of the neck and to determine whether CT characteristics could distinguish malignant from benign thyroid lesions...
  60. ncbi Incidental findings in healthy control research subjects using whole-body MRI
    S H X Morin
    Division of Medicine, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Campus, London W12 0NN, UK
    Eur J Radiol 72:529-33. 2009
    ..We aimed to assess the prevalence of incidental findings in a sequential cohort of healthy volunteers undergoing whole-body MRI as part of a normal control database ..
  61. ncbi Non-cardiac findings on coronary computed tomography and magnetic resonance imaging
    Marc Dewey
    Department of Radiology, Charite Universitatsmedizin Berlin, Humboldt Universitat zu Berlin, Chariteplatz 1, P O Box 10098, 10117 Berlin, Germany
    Eur Radiol 17:2038-43. 2007
    ....
  62. ncbi Ability of integrated positron emission and computed tomography to detect significant colonic pathology: the experience of a tertiary cancer center
    Brian R Weston
    Department of Gastroenterology, Hepatology and Nutrition, Unit 1466, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 1402, USA
    Cancer 116:1454-61. 2010
    ..The purpose of this study was to assess the ability of PET-CT to detect colonic pathology and to determine the significance of ((18)F)2-fluoro-2-deoxyglucose ((18)F-FDG) activity noted incidentally in the colon on PET-CT...
  63. ncbi Adrenal incidentalomas: 'the rule of four'
    Krystallenia I Alexandraki
    Department of Endocrinology, St Bartholomew s Hospital, London
    Clin Med 8:201-4. 2008
  64. ncbi Economic impact of extracolonic findings at computed tomographic colonography
    Michael S Flicker
    Department of Medicine, University of Chicago Hospitals, Chicago, IL 60637, USA
    J Comput Assist Tomogr 32:497-503. 2008
    ..To determine the prevalence of extracolonic findings at computed tomographic colonography (CTC) and estimate the cost of the workup of newly discovered potentially significant lesions...
  65. ncbi Frequency and follow-up of incidental findings on trauma computed tomography scans: experience at a level one trauma center
    Marc David Munk
    Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Emerg Med 38:346-50. 2010
    b>Incidental findings found on computed tomography (CT) scan during the Emergency Department evaluation of trauma patients are often benign, but their presence must always be communicated to patients, who should be referred for follow-up ..
  66. ncbi Incidental findings on pediatric MR images of the brain
    Brian S Kim
    Department of Radiology, Stanford Center for Biomedical Ethics, Stanford, CA 94304, USA
    AJNR Am J Neuroradiol 23:1674-7. 2002
    Previous studies have addressed the prevalence of incidental findings in symptomatic and healthy adult populations. Our study aims to elucidate the prevalence of incidental findings in a healthy pediatric population.
  67. pmc Adrenal incidentalomas in the laparoscopic era and the role of correct surgical indications: observations from 255 consecutive adrenalectomies in an Italian series
    Giovanni Conzo
    General and Endocrine Surgery, Second University of Naples, Naples, Italy
    Can J Surg 52:E281-5. 2009
    ..We analyzed the results of a multi-centre trial that was performed to evaluate the effectiveness of imaging (computed tomography and magnetic resonance imaging) to obtain a correct preoperative diagnosis...
  68. ncbi Incidental findings in trauma patients during focused assessment with sonography for trauma
    Sophocles Lanitis
    Second Surgical Department and Unit of Surgical Oncology, Korgialenio Benakio, Red Cross Athens General Hospital, Athens, Greece
    Am Surg 78:366-72. 2012
    ..they usually undergo a Focused Assessment with Sonography for Trauma (FAST) in which there are occasionally incidental findings of other surgical conditions...
  69. ncbi Research malpractice and the issue of incidental findings
    Alan C Milstein
    Sherman Silverstein Kohl Rose and Podolsky, Pennsauken, NJ, USA
    J Law Med Ethics 36:356-60, 214. 2008
    Human subject research involving brain imaging is likely to reveal significant incidental findings of abnormal brain morphology...
  70. ncbi Adrenal incidentaloma: does an adequate workup rule out surprises?
    Raymon H Grogan
    Department of Endocrine Surgery, University of California San Francisco, San Francisco, CA 94143, USA
    Surgery 148:392-7. 2010
    ..We sought to determine how accurately these guidelines identify functioning incidentalomas and how often these guidelines result in adrenalectomy for benign tumors...
  71. pmc Genomic research and incidental findings
    Brian Van Ness
    Department of Genetics, Cell Biology and Development at the University of Minnesota, MN, USA
    J Law Med Ethics 36:292-7, 212. 2008
    ..These incidental findings create legal, ethical, and financial challenges for researchers...
  72. ncbi Incidental findings at initial imaging workup of patients with prostate cancer: clinical significance and outcomes
    Azadeh Elmi
    Division of Abdominal Imaging and Interventional Radiology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, White 270, Boston, MA 02114, USA
    AJR Am J Roentgenol 199:1305-11. 2012
    The purpose of this article is to evaluate the frequency and clinical relevance of incidental findings in patients with prostate cancer who underwent abdominopelvic contrast-enhanced CT examination for initial staging workup.
  73. ncbi Prevalence of incidental pancreatic cysts in the adult population on MR imaging
    Karen S Lee
    Department of Radiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Am J Gastroenterol 105:2079-84. 2010
    ..The aim of our study was to determine the prevalence of incidentally detected pancreatic cysts in the adult population undergoing abdominal magnetic resonance (MR) imaging...
  74. pmc Empirical analysis of current approaches to incidental findings
    Frances Lawrenz
    University of Minnesota, MN, USA
    J Law Med Ethics 36:249-55, 211. 2008
    ..S. data sources for information about how to handle incidental findings (IF) in human subjects research, especially in genetics and genomics research, neuroimaging research, and ..
  75. pmc Incidental findings on brain magnetic resonance imaging of children with sickle cell disease
    Lori C Jordan
    Department of Neurology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Pediatrics 126:53-61. 2010
    ..We describe the prevalence and range of incidental intracranial abnormalities identified through MRI of the brain in a large group of children screened for a clinical trial...
  76. ncbi Incidental findings in brain MRI research: what do we owe our subjects?
    Ronald J H Borra
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School Boston, Massachusetts 02129, USA
    J Am Coll Radiol 8:848-52. 2011
    Concern regarding incidental findings on brain MRI studies has been increasing with the growing use of MRI as tool for scientific investigation...
  77. ncbi An empirical examination of the management of return of individual research results and incidental findings in genomic biobanks
    Gina Johnson
    Department of Educational Psychology, College of Education and Human Development, University of Minnesota, Twin Cities, Minneapolis, Minnesota, USA
    Genet Med 14:444-50. 2012
    The purpose of this study was to examine and document the management and return of individual research results and incidental findings to research participants among biobanks.
  78. ncbi [Depression and anxiety in patients with adrenal tumor incidentally found on abdominal imaging performed for other indications]
    Maciej Owecki
    Katedra i Klinika Endokrynologii, Przemiany Materii i Chorób Wewngtrznych Akademii Medycznej, Poznaniu
    Pol Merkur Lekarski 19:166-8. 2005
    ..The aim of this study was to assess the level of anxiety and depression in patients with non-secreting adrenal incidentaloma...
  79. ncbi Cohort study of patients with adrenal lesions discovered incidentally
    A Muth
    Department of Surgery, Sahlgrenska University Hospital, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    Br J Surg 98:1383-91. 2011
    ..This prospective cohort study investigated the incidence, clinical features and natural history of incidentally discovered adrenal mass lesions (adrenal incidentaloma, AI) in an unselected population undergoing radiological examination...
  80. pmc Taking aims seriously: repository research and limits on the duty to return individual research findings
    Pilar Ossorio
    Morgridge Institute for Research, Madison, Wisconsin, USA
    Genet Med 14:461-6. 2012
    Most discussions of researchers' duties to return incidental findings or research results to research participants or repository contributors fail to provide an adequate theoretical grounding for such duties...
  81. ncbi Significance of incidental thyroid lesions detected on CT: correlation among CT, sonography, and pathology
    Sanjay K Shetty
    Department of Radiology, Massachusetts General Hospital, FND 214, 55 Fruit St, Boston, MA 02114, USA
    AJR Am J Roentgenol 187:1349-56. 2006
    ....
  82. pmc Incidental findings and ancillary-care obligations
    Henry S Richardson
    Georgetown University, Washington, DC, USA
    J Law Med Ethics 36:256-70, 211. 2008
    Recent work on incidental findings, concentrating on the difficult problems posed by the ambiguous results often generated by high-tech medicine, has proceeded largely independently from recent work on medical researchers' ancillary-care ..
  83. pmc Incidental findings of brain magnetic resonance imaging study in a pediatric cohort in Japan and recommendation for a model management protocol
    Ayumi Seki
    Research Institute of Science and Technology for Society, Japan Science and Technology Agency, Tokyo, Japan
    J Epidemiol 20:S498-504. 2010
    The increasing use of magnetic resonance imaging (MRI) in brain researches has led to growing concern over incidental findings (IFs)...
  84. ncbi Guidelines reduce the risk of brain-scan shock
    John D Pickard
    Nature 435:17. 2005
  85. ncbi Prevalence of non-cardiac findings in a large series of patients undergoing cardiac multi-detector computed tomography scans
    Pow Li Chia
    Department of Cardiology, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore, Singapore
    Int J Cardiovasc Imaging 25:537-43. 2009
    ..These lesions commonly occurred in the lungs and the liver. Age and active smoking were predictive of the presence of non-cardiac abnormalities...
  86. pmc Incidental findings found in "healthy" volunteers during imaging performed for research: current legal and ethical implications
    T C Booth
    Royal Free Hospital NHS Trust, Department of Radiology, Pond Street, London, UK
    Br J Radiol 83:456-65. 2010
    b>Incidental findings found in "healthy" volunteers during research imaging are common and have important implications for study design and performance, particularly in the areas of informed consent, subjects' rights, clinical image ..
  87. ncbi Incidental findings of pathology and abnormality in pretreatment orthodontic panoramic radiographs
    Lars Bondemark
    Department of Orthodontics, Faculty of Odontology, Malmo University, Malmo, Sweden
    Angle Orthod 76:98-102. 2006
    ..The aim of this study was to evaluate the prevalence and location of incidental findings of pathology and abnormalities in pretreatment orthodontic panoramic radiographs...
  88. ncbi Incidental findings in the maxillofacial region detected by cone beam CT
    Fatma Caglayan
    Department of Oral Diagnosis and Radiology, Faculty of Dentistry, Ataturk University, Erzurum, Turkey
    Diagn Interv Radiol 18:159-63. 2012
    ..The purpose of this study was to determine the location, nature, and occurrence of incidental maxillofacial findings on cone beam computed tomography (CBCT) scans performed for maxillofacial diagnostic purposes...
  89. ncbi Incidental findings of persistent primitive trigeminal artery on 3-dimensional time-of-flight magnetic resonance angiography at 3.0 T: an analysis of 25 cases
    Yuan Chang Chen
    Institute of Diagnostic and Interventional Radiology, Department of Neurosurgery, The Sixth People s Hospital, Shanghai Jiaotong University, Shanghai, China
    J Neuroimaging 21:152-8. 2011
    ..This study is to evaluate the efficacy of 3-dimensional time-of-flight magnetic resonance angiography (3D-TOF MRA) at 3.0 T for the detection and classification of PPTA based on a large case series...
  90. ncbi Detection of clinically unexpected malignant and premalignant tumors with whole-body FDG PET: histopathologic comparison
    Harry Agress
    Department of Radiology, Division of Nuclear Medicine, Hackensack University Medical Center, 30 Prospect Ave, Hackensack, NJ 07601, USA
    Radiology 230:417-22. 2004
    ..To determine the clinical importance and malignant potential of unexpected abnormal foci of hypermetabolism at fluorodeoxyglucose (FDG) positron emission tomography (PET) performed for evaluation of malignancy...
  91. ncbi Incidental findings on cardiac multidetector row computed tomography among healthy older adults: prevalence and clinical correlates
    Jeremy R Burt
    Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
    Arch Intern Med 168:756-61. 2008
    With the widespread use of cardiac multidetector row computed tomography (MDCT), the issue of incidental findings is receiving increasing attention...
  92. pmc Incidental non-cardiac findings of a coronary angiography with a 128-slice multi-detector CT scanner: should we only concentrate on the heart?
    Olga Lazoura
    Department of Radiology, Medical School of Thessaly, Mezourlo, Larissa 41110, Greece
    Korean J Radiol 11:60-8. 2010
    ..To evaluate the spectrum, prevalence, and significance of incidental non-cardiac findings (INCF) in patients referred for a non-invasive coronary angiography using a 128-slice multi-detector CT (MDCT)...
  93. ncbi Incidental thyroid nodules on chest CT: Review of the literature and management suggestions
    Sameer Ahmed
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    AJR Am J Roentgenol 195:1066-71. 2010
    ..This article will review the current literature regarding the detection of thyroid nodules with an emphasis on CT diagnosis. We will also discuss management strategies...
  94. ncbi Current role and future potential of computed tomographic colonography for colorectal polyp detection and colon cancer screening-incidental findings
    Christian Sohns
    Department of Radiology, Georg August University Goettingen, Robert Koch Str 40, 37099 Goettingen, Germany
    Clin Imaging 32:280-6. 2008
    ..In this retrospective study, we assess the current role and future potential of computed tomographic (CT) colonography as a viable alternative imaging tool for colorectal polyp detection and colon cancer screening...
  95. ncbi Laparoscopic excision of malignant struma ovarii and 1 year follow-up without further treatment
    Bernhard Kraemer
    Department of Obstetrics and Gynecology, University Hospital for Women, and Department of Pathology, University of Tubingen, Tubingen, Germany
    Fertil Steril 95:2124.e9-12. 2011
    ..To report the case of a patient with malignant struma ovarii, which was excised endoscopically...
  96. pmc Incidental findings in imaging diagnostic tests: a systematic review
    B Lumbreras
    Departament of Public Health, University Miguel Hernandez, Alicante, Spain
    Br J Radiol 83:276-89. 2010
    The objective of this review is to summarise the available evidence on the frequency and management of incidental findings in imaging diagnostic tests...
  97. ncbi Significance of cardiac computed tomography incidental findings in acute chest pain
    Sam J Lehman
    Massachusetts General Hospital Cardiac MR PET CT Program and Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Med 122:543-9. 2009
    ..management of patients presenting to the emergency department with acute chest pain; however, noncoronary incidental findings are frequently detected...
  98. ncbi Incidental findings on MRI of the spine
    S Kamath
    Department of Radiology, University Hospital of Wales, Cardiff, UK
    Clin Radiol 64:353-61. 2009
    ..of such findings and describes a sensible approach to the reporting of MRI examinations of the spine with special attention to the incidental findings commonly encountered. The MRI characteristics of such findings are briefly described.
  99. ncbi Non-Hodgkin lymphoma as an unexpected diagnosis after elective total knee arthroplasty
    Alex James Stewart Watson
    The Royal London Hospital, Department of Orthopaedics, London, UK
    J Arthroplasty 23:612-4. 2008
    ..We report a case of non-Hodgkin lymphoma as an unexpected diagnosis after pathologic examination of unusual-looking femoral condyle bone block harvested during total knee arthroplasty in an asymptomatic patient...
  100. ncbi Extracardiac findings in cardiac computed tomographic angiography in patients at low to intermediate risk for coronary artery disease
    Vikram Venkatesh
    Department of Radiology, McMaster University, Hamilton, Ontario, Canada
    Can Assoc Radiol J 61:286-90. 2010
    ..To evaluate the prevalence, clinical significance, interobserver agreement, and follow-up of extracardiac findings on coronary computed tomographic angiography (CTA)...
  101. pmc Discovery and disclosure of incidental findings in neuroimaging research
    Judy Illes
    Stanford Center for Biomedical Ethics, Stanford University, Stanford, California 94304 5748, USA
    J Magn Reson Imaging 20:743-7. 2004
    To examine different protocols for handling incidental findings on brain research MRIs, and provide a platform for establishing formal discussions of related ethical and policy issues.

Research Grants60

  1. Managing Incidental Findings and Research Results in Genomic Biobanks and Archive
    Susan M Wolf; Fiscal Year: 2010
    This 2-year renewal project builds on our previous NHGRI-funded project on "Managing Incidental Findings in Human Subjects Research" (#1 R01 HG003178-01A1)...
  2. THE ETHICS OF POST-CONFLICT AND POST-DISASTER DNA IDENTIFICATION
    Sarah Wagner; Fiscal Year: 2013
    ..second relates to ethical issues associated with the use of DNA identification, including: how to deal with incidental findings (e.g...
  3. RCT of US versus CT for Patients in the ED with Suspected Renal Colic
    Rebecca Smith Bindman; Fiscal Year: 2010
    ..Second, computed tomography identifies many incidental findings that result in further testing, clinical follow up, and treatment that may be unnecessary...
  4. Economic Consequences of Advanced Testing for Subclinical Cardiovascular Disease
    Leslee J Shaw; Fiscal Year: 2010
    ..including improved risk re-classification as well as the cumulative costs (including those associated with incidental findings and expected radiation- induced cancers)...
  5. Risk of Cancer in Incidental Findings Identified on Ultrasound Imaging
    Rebecca Smith-Bindman; Fiscal Year: 2013
    ..a Mid Career Investigator Award in Patient Oriented Research to evaluate the risk of cancer associated with incidental findings identified on ultrasound imaging, and to increase the time she devotes to teaching and mentoring radiology ..
  6. Disclosing Genomic Incidental Findings in a Cancer Biobank: An ELSI Experiment
    Susan M Wolf; Fiscal Year: 2013
    ..and normative bioethics research project will guide policy and practice about the disclosure of genomic incidental findings (GIFD), a much-debated topic...
  7. Leveraging genetics and environment to predict presymptomatic multiple sclerosis
    Zongqi Xia; Fiscal Year: 2013
    ..as family members or patients with Radiologically Isolated Syndrome (RIS: asymptomatic individuals with incidental findings of MS-like lesions on brain magnetic resonance imaging, MRI)...
  8. Managing Incidental Findings in the Genomic Era
    JANET K contact WILLIAMS; Fiscal Year: 2010
    ....
  9. Toward Individually-tailored Medicine: Probabilistic Models of Cerebral Aneurysms
    Fernando Vinuela; Fiscal Year: 2012
    ....
  10. Clinical sequencing in cancer: Clinical ethical and technological studies
    GAIL PAIRITZ JARVIK; Fiscal Year: 2013
    ..After deliberations by experts to identify variants that are incidental findings that should be returned, we will also return CLIA certified results to the participants...
  11. Quality of Life in People with Abdominal Aortic Aneurysms
    BRIAN WILLIAM NOLAN; Fiscal Year: 2013
    ..RELEVANCE (See instructions): Given the increasing diagnosis of AAA through screening and incidental findings, AAA surveillance will be a growing issue in the United States...
  12. Incorporation of Genomic Sequencing into Pediatric Cancer Care
    Sharon E Plon; Fiscal Year: 2013
    ..Ethical issues related to the appropriate use and reporting of whole exome data including possible incidental findings in a pediatric setting will be addressed...
  13. A Pragmatic Trial of Lumbar Image Reporting with Epidemiology (LIRE)
    Jeffrey G Jarvik; Fiscal Year: 2012
    ..a context for both physicians and patients to better interpret imaging findings may reduce concern about incidental findings and reduce unnecessary further diagnostic tests and treatments...
  14. Genomic Diagnosis in Children with Developmental Delay
    Richard M Myers; Fiscal Year: 2013
    ..aspects of self-perception and well-being that may be altered as a result of the genetic diagnosis and incidental findings. Related questions about risks and benefits of probabilistic information and genomic information that does ..
  15. PROMISE Trial: Substudy to Assess for Effective Dose of Radiation
    ANDREW EINSTEIN; Fiscal Year: 2013
    ..This will include tracking subsequent tests for CAD evaluation and tests to evaluate incidental findings such as pulmonary nodules, and measured or imputed patient-specific dosimetry estimates from each follow-up ..
  16. NC NEXUS, North Carolina Newborn Exome Sequencing for Universal Screening
    CYNTHIA MARION POWELL; Fiscal Year: 2013
    ..guide clinicians, clinical laboratories and patients/families in their decisions regarding the inevitable incidental findings that will be detected in ways that respect the child and protect his/her future autonomy, while also ..
  17. Sequencing of Newborn Blood Spot DNA to Improve and Expand Newborn Screening
    Robert L Nussbaum; Fiscal Year: 2013
    ..Equally important, we will explore parents'interest in incidental findings and develop appropriate legal frameworks to make sure NBS by WGA can be done ethically.
  18. Risk of Cancer with Incidental Findings Identified on Ultrasound Imaging
    Rebecca Smith Bindman; Fiscal Year: 2010
    ..of the increased utilization and resolution of imaging is the diagnosis of increasing numbers of incidental findings (unexpected, asymptomatic findings) and indeterminate findings (findings related to the reason for imaging, ..
  19. Impact of return of incidental genetic test results to research participants in t
    Jo C Phelan; Fiscal Year: 2013
    ..with varying degrees of access to and connection with the research participants, and the range of possible incidental findings that could be reported and the differential responsibility to report these results based upon the clinical ..
  20. Applying Genomic Sequencing in Pediatrics
    Ian D Krantz; Fiscal Year: 2013
    ..will validate our ability to Identify clinically significant findings, as well as our ability to identify incidental findings and determine which o these will be useful to families...
  21. Optimization of incidental findings disclosure to research subjects
    John P Phillips; Fiscal Year: 2013
    ..For example, incidental findings (IF) are often identified, but there are no clear guidelines on how to deal with this information...
  22. Presenting Genome Information in Patient Electronic Records: The Informed Cohort
    KENNETH D contact MANDL; Fiscal Year: 2010
    ..or symptomatology or clinical evaluation, it appears likely that the incidentalome (the collection of all incidental findings due to comprehensive genetic testing) is likely to grow rapidly...
  23. Ultrasound-Mediated Blood-Brain Barrier Permeabilization in Primates
    Steven Gullans; Fiscal Year: 2006
    ..This research aims to develop a method to deliver drugs and other therapies to the brain in a way that is safe and easy to apply. [unreadable] [unreadable]..
  24. Ultrasound-Mediated Blood-Brain Barrier Permeabilization in Primates
    Matthew Lawrence; Fiscal Year: 2009
    ..We are developing a safe ultrasound device to allow drugs and other therapies to enter the brain and treat these and other neurological diseases. ..
  25. Disclosure of Results from Genetic Research Studies
    Lynn Dressler; Fiscal Year: 2006
    ..is, if, when, and under what conditions should the results of genetic research studies, including incidental findings, be disclosed to the individual, his/her family, or his/her physician. [unreadable] [unreadable] [unreadable]..
  26. Preventing the Incidentalome
    Isaac S Kohane; Fiscal Year: 2010
    ..Evidence supporting this hypothesis will both serve as an important caution in the use of genetic testing and will also demonstrate the value of population studies to find the broader clinical significance of genetic mutations. ..
  27. Index and Retrieval of Pathology Specimens
    Isaac Kohane; Fiscal Year: 2005
    ..abstract_text> ..
  28. GPing: Informatics for Personal Control of Genomic Data
    Isaac S Kohane; Fiscal Year: 2010
    ..3: Design and evaluate a user interface to communicate disclosure. In concert with appropriate non-discrimination legislation, G-PING lays the groundwork for large-scale genomic cohort studies. ..
  29. Exploring Attitudes About Data Disclosure and Data-Sharing in Genomics Research
    Susanne Haga; Fiscal Year: 2008
    ..The success of large-scale genomics research initiatives will depend on the support and participation of the public and therefore, their views are critically important to obtain. [unreadable] [unreadable] [unreadable]..
  30. Ventricular Size and Valve Calcification Measures by CT
    Matthew J Budoff; Fiscal Year: 2010
    ..abstract_text> ..
  31. 3D CT Cephalometrics and Family History in Sleep Apnea
    Reyes Enciso; Fiscal Year: 2008
    ..The 5th year's focus will be on report and grant writing. [unreadable] [unreadable]..
  32. Advanced Neuroimaging: Ethical, Legal, and Social Issues
    Judy Illes; Fiscal Year: 2005
    ..abstract_text> ..
  33. NEWBORN GENETIC SCREENING:FOR WHOSE BENEFIT?
    Lainie Ross; Fiscal Year: 2005
    ..OUTCOMES: The major outcomes will be a series of peer-reviewed articles and a full-length book entitled Newborn Genetic Screening: In whose Interest? For whose Benefit? ..
  34. EVALUATING USE OF GENETIC INFORMATION: A MODEL PROCESS
    Wylie Burke; Fiscal Year: 2003
    ..5. To conduct an evaluation of the model process within a large health care system. ..
  35. ROBUST LINKAGE METHODS FOR HUMAN PEDIGREE DATA
    Katrina Goddard; Fiscal Year: 2004
    ..At the end of the project period, a comprehensive set of tools for model-free affected relative pair analysis will be available. ..
  36. Family Health After Predictive HD Testing
    Janet Williams; Fiscal Year: 2004
    ..This study will document the health care needs of family members of persons who receive a positive result from presymptomatic gene testing for an inherited degenerative neurologic disease. ..
  37. Microarray analysis of thyroid neoplasm
    Martha Zeiger; Fiscal Year: 2004
    ..This will be performed using quantitative real-time RT-PCR on RNA samples from a panel of thyroid tumors. ..
  38. RECOVERY FROM STROKE: A CLINICAL & FUNCTIONAL MRI STUDY
    Steven Cramer; Fiscal Year: 2003
    ..3) MGH-NMR Center (Charlestown, MA), located two miles from (1) and (2), is a pioneering fMRI center. ..
  39. GENES CONTROLLING VIRUS INDUCED ASTHMA IN RATS
    William Castleman; Fiscal Year: 2002
    ....
  40. COMPARISON OF TREATMENT EFFICACY FOR PROSTATE CANCER
    Peter Albertsen; Fiscal Year: 2002
    ....
  41. NURSING CDROM ON ETHICAL ISSUES OF GENETIC TESTING
    Janet Williams; Fiscal Year: 2002
    ..Increased knowledge of ethical aspects of genetic testing will enable professional nurses to incorporate this knowledge into their professional nursing roles. ..
  42. Monochromatic Phase-Contrast Breast Cancer Radiography
    Edwin Donnelly; Fiscal Year: 2005
    ..Image quality of all images will be judged by an experienced mammographer. ..
  43. Outcome Measures in Idiopathic Intracranial Hypertension
    Deborah Friedman; Fiscal Year: 2008
    ..Acquire the training, mentoring and experience necessary to conduct independent, funded clinical research in ophthalmologic and neurological disorders Obtain a Masters Degree in Public Health/Clinical Investigator track ..
  44. PATHOGENESIS OF HEPATIC FIBROSIS AND PORTAL HYPERTENSION
    Don C Rockey; Fiscal Year: 2010
    ..These studies have direct relevance to human liver disease and will lead to new approaches for the treatment of hepatic fibrosis and portal hypertension as well as other forms of fibrosing injury. ..
  45. Attention, Memory, and Executive Function in Fragile X
    Donald Bailey; Fiscal Year: 2006
    ..abstract_text> ..
  46. Phase Contrast Computed Tomography Scanner
    Edwin Donnelly; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  47. Prediction and Progression of Carotid Artery Disease
    GAIL JARVIK; Fiscal Year: 2009
    ..Aim 3: Pathway evaluation of oxidative loci and phenotypes in prediction of CAAD. ..
  48. Safety of Autologous Marrow Stromal Cells After Stroke
    Steven Cramer; Fiscal Year: 2005
    ..This study is a Phase I safety trial, and thus represents the first step in evaluating autologous MSC transfusion in this regard. ..
  49. Inflammatory Genomics in Human Carotid Artery Disease
    GAIL JARVIK; Fiscal Year: 2006
    ..Genes that are implicated in disease may eventually allow targeted therapy. ..
  50. Community Consultation as an Ethics Method
    Pilar Ossorio; Fiscal Year: 2006
    ..This project wilt yield several manuscripts aimed at professional, policy and public (non-expert) audiences. ..
  51. Molecular Classification of Suspicious Thyroid Tumors
    Martha Zeiger; Fiscal Year: 2009
    ..abstract_text> ..
  52. Clinical Approaches to Ileal Pouch Dysfunction
    Bo Shen; Fiscal Year: 2005
    ..The AIMS of study are to 1) investigate visceral hypersensitivity using barostat examination of the pouch; 2) conduct a randomized, placebo-controlled clinical trial evaluating the use of amitriptyline in IPS. ..
  53. Cadmium, Metallothionein and Breast Cancer Progression
    MARY SENS; Fiscal Year: 2008
    ..abstract_text> ..
  54. Safety of repetitive TMS in chronic subcortical stroke
    Steven Cramer; Fiscal Year: 2006
    ..The long-term goal of these studies is to develop a safe and efficacious method for facilitating motor cortex function in order to improve motor status of patients with stroke-related weakness. ..
  55. Outcomes of Prolonged Mechanical Ventilation
    Shannon Carson; Fiscal Year: 2006
    ..In addition, these data will inform future cohort studies and randomized controlled trials designed to improve outcomes for this growing patient population. ..
  56. Pharmacotherapy for Minor Depression
    Robert Howland; Fiscal Year: 2004
    ..The results of this study will have profound public health implications by improving our understanding of the efficacy of SJW and standard antidepressants for the treatment of MinorD. ..
  57. Nitric Oxide and the Liver
    Don Rockey; Fiscal Year: 2003
    ..The dates of the entire AASLD scientific meeting are November 3rd to November 5th. The participants will be invited speakers and attendees of the annual 2002 AASLD meeting. ..
  58. Regulation of Stellate Cell Contractility
    Don Rockey; Fiscal Year: 2008
    ..Physiologic endpoints will be an important focus. The proposed studies will shed light on the molecular basis of stellate cell contractility and moreover have direct relevance to human liver disease. ..
  59. PROSPECTIVE COMPARISON OF COLONIC IMAGING TEST
    Don Rockey; Fiscal Year: 2001
    ..The information gained from this study is expected to form the basis for national policy and decision making with reward to colonic imaging tests. ..