early diagnosis


Summary: Methods to determine in patients the nature of a disease or disorder at its early stage of progression. Generally, early diagnosis improves PROGNOSIS and TREATMENT OUTCOME.

Top Publications

  1. doi 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative
    Daniel Aletaha
    Arthritis Research UK, Copeman House, Chesterfield, UK
    Ann Rheum Dis 69:1580-8. 2010
  2. doi Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans
    Guo Kun Wang
    Department of Cardiology, Changhai Hospital, 168 Changhai Road, Shanghai 200433, People s Republic of China
    Eur Heart J 31:659-66. 2010
  3. doi Early diagnosis of myocardial infarction with sensitive cardiac troponin assays
    Tobias Reichlin
    Department of Internal Medicine, University Hospital, Basel, Switzerland
    N Engl J Med 361:858-67. 2009
  4. ncbi Autoantibodies in breast cancer: their use as an aid to early diagnosis
    C Chapman
    Division of Breast Surgery, The University of Nottingham, Nottingham, UK
    Ann Oncol 18:868-73. 2007
  5. doi Prodromal Alzheimer's disease: successive emergence of the clinical symptoms
    Helene Amieva
    Institut National de la Sante et de la Recherche Medicale, U897, France
    Ann Neurol 64:492-8. 2008
  6. doi Identifying early markers of Alzheimer's disease using quantitative multiplex proteomic immunoassay panels
    Holly D Soares
    Pfizer Global Research and Development, Groton, Connecticut, USA
    Ann N Y Acad Sci 1180:56-67. 2009
  7. ncbi Early detection of pulmonary arterial hypertension in systemic sclerosis: a French nationwide prospective multicenter study
    Eric Hachulla
    Hopital Claude Huriez, Lille, France
    Arthritis Rheum 52:3792-800. 2005
  8. pmc Introducing a multi-site program for early diagnosis of HIV infection among HIV-exposed infants in Tanzania
    Harriet Nuwagaba-Biribonwoha
    Columbia University, International Centre for AIDS Care and Treatment Programs ICAP, Dar es Salaam, Tanzania
    BMC Pediatr 10:44. 2010
  9. doi Differential expression profiles of microRNAs as potential biomarkers for the early diagnosis of esophageal squamous cell carcinoma
    Miao Yang
    Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, Jiangsu 210009, PR China
    Oncol Rep 29:169-76. 2013
  10. pmc Using community-owned resource persons to provide early diagnosis and treatment and estimate malaria burden at community level in north-eastern Tanzania
    Acleus S M Rutta
    National Institute for Medical Research, Tanga Centre, P O Box 5004, Tanga, Tanzania
    Malar J 11:152. 2012

Detail Information

Publications398 found, 100 shown here

  1. doi 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative
    Daniel Aletaha
    Arthritis Research UK, Copeman House, Chesterfield, UK
    Ann Rheum Dis 69:1580-8. 2010
    ..This work was undertaken to develop new classification criteria for RA...
  2. doi Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans
    Guo Kun Wang
    Department of Cardiology, Changhai Hospital, 168 Changhai Road, Shanghai 200433, People s Republic of China
    Eur Heart J 31:659-66. 2010
    ..We aim to determine the potential of cardiac-specific miRNAs in circulation to serve as biomarkers for acute myocardial infarction (AMI)...
  3. doi Early diagnosis of myocardial infarction with sensitive cardiac troponin assays
    Tobias Reichlin
    Department of Internal Medicine, University Hospital, Basel, Switzerland
    N Engl J Med 361:858-67. 2009
    ..The rapid and reliable diagnosis of acute myocardial infarction is a major unmet clinical need...
  4. ncbi Autoantibodies in breast cancer: their use as an aid to early diagnosis
    C Chapman
    Division of Breast Surgery, The University of Nottingham, Nottingham, UK
    Ann Oncol 18:868-73. 2007
    ..There is increasing evidence that the immune system produces a humoral response to cancer-derived antigens. This study assessed the diagnostic potential of autoantibodies to multiple known tumour-associated proteins...
  5. doi Prodromal Alzheimer's disease: successive emergence of the clinical symptoms
    Helene Amieva
    Institut National de la Sante et de la Recherche Medicale, U897, France
    Ann Neurol 64:492-8. 2008
    ..Utilizing the long follow-up of the PAQUID study, we examined the emergence of the first clinical symptoms over a 14-year period of follow-up before the dementia phase of AD...
  6. doi Identifying early markers of Alzheimer's disease using quantitative multiplex proteomic immunoassay panels
    Holly D Soares
    Pfizer Global Research and Development, Groton, Connecticut, USA
    Ann N Y Acad Sci 1180:56-67. 2009
    ..Extensive research efforts are focused upon identifying new treatments, and early diagnosis is considered key to successful intervention...
  7. ncbi Early detection of pulmonary arterial hypertension in systemic sclerosis: a French nationwide prospective multicenter study
    Eric Hachulla
    Hopital Claude Huriez, Lille, France
    Arthritis Rheum 52:3792-800. 2005
  8. pmc Introducing a multi-site program for early diagnosis of HIV infection among HIV-exposed infants in Tanzania
    Harriet Nuwagaba-Biribonwoha
    Columbia University, International Centre for AIDS Care and Treatment Programs ICAP, Dar es Salaam, Tanzania
    BMC Pediatr 10:44. 2010
    ..In this setting where other infections and malnutrition mimic signs and symptoms of AIDS, early diagnosis of HIV among HIV-exposed infants without specialized virologic testing can be a complex process...
  9. doi Differential expression profiles of microRNAs as potential biomarkers for the early diagnosis of esophageal squamous cell carcinoma
    Miao Yang
    Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, Jiangsu 210009, PR China
    Oncol Rep 29:169-76. 2013
    ..Tumor-specific microRNAs (miRNAs) seem to be potential biomarkers for the early diagnosis and treatment of cancer...
  10. pmc Using community-owned resource persons to provide early diagnosis and treatment and estimate malaria burden at community level in north-eastern Tanzania
    Acleus S M Rutta
    National Institute for Medical Research, Tanga Centre, P O Box 5004, Tanga, Tanzania
    Malar J 11:152. 2012
    Although early diagnosis and prompt treatment is an important strategy for control of malaria, using fever to initiate presumptive treatment with expensive artemisinin combination therapy is a major challenge; particularly in areas with ..
  11. ncbi Urinary IL-18 is an early predictive biomarker of acute kidney injury after cardiac surgery
    C R Parikh
    Section of Nephrology, Yale University, New Haven, Connecticut 06516, USA
    Kidney Int 70:199-203. 2006
    ..The combination of these two biomarkers may allow for the reliable early diagnosis and prognosis of AKI at all times after CPB, much before the rise in serum creatinine.
  12. ncbi Amnestic syndrome of the medial temporal type identifies prodromal AD: a longitudinal study
    M Sarazin
    INSERM U 610 and Centre des Maladies Cognitives et Comportementales, Hopital de la Salpetriere, Paris, France
    Neurology 69:1859-67. 2007
    ..To compare the power of tests assessing different cognitive domains for the identification of prodromal Alzheimer disease (AD) among patients with mild cognitive impairment (MCI)...
  13. doi Universal HIV testing of infants at immunization clinics: an acceptable and feasible approach for early infant diagnosis in high HIV prevalence settings
    Nigel Rollins
    Department of Paediatrics and Child Health, University of KwaZulu Natal, Durban, South Africa
    AIDS 23:1851-7. 2009
    To determine the acceptability and feasibility of universal HIV testing of 6-week-old infants attending immunization clinics to achieve early diagnosis of HIV and referral for HIV treatment and care services.
  14. doi Sensitive troponin I assay in early diagnosis of acute myocardial infarction
    Till Keller
    Department of Medicine II, University Medical Center, Johannes Gutenberg University, Mainz, Germany
    N Engl J Med 361:868-77. 2009
    Cardiac troponin testing is central to the diagnosis of acute myocardial infarction. We evaluated a sensitive troponin I assay for the early diagnosis and risk stratification of myocardial infarction.
  15. doi Early diagnosis of sepsis using serum biomarkers
    Terence Chan
    Department of Chemical Engineering, University of Waterloo, ON, Canada
    Expert Rev Mol Diagn 11:487-96. 2011
    ..The ongoing efforts in the development of a multiplex point-of-care testing kit, enabling quick and reliable detection of serum biomarkers, may have great potential for early diagnosis of sepsis.
  16. pmc Does provider-initiated counselling and testing (PITC) strengthen early diagnosis and treatment initiation? Results from an analysis of an urban cohort of HIV-positive patients in Lusaka, Zambia
    Stephanie M Topp
    Centre for Infectious Disease Research in Zambia, Lusaka, Zambia
    J Int AIDS Soc 15:17352. 2012
    ..We additionally seek to determine whether there are any significant differences in the clinical and demographic profile of PITC and VCT clients...
  17. ncbi Early diagnosis of cutaneous melanoma: an observation in southern Brazil
    Raquel Bonfá
    Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brasil
    An Bras Dermatol 86:215-21. 2011
    ..The incidence of melanoma cutaneous and the mortalities rates are rising in most countries worldwide...
  18. ncbi Early diagnosis and follow-up of aortitis with [(18)F]FDG PET and MRI
    J Meller
    Department of Nuclear Medicine, Georg August University, Gottingen, Germany
    Eur J Nucl Med Mol Imaging 30:730-6. 2003
    ..In a limited number of patients [(18)F]FDG PET was more reliable than MRI in monitoring disease activity during immunosuppressive therapy...
  19. doi Clinical and cost effectiveness of services for early diagnosis and intervention in dementia
    Sube Banerjee
    Section of Mental Health and Ageing, The Institute of Psychiatry, King s College London, London, UK
    Int J Geriatr Psychiatry 24:748-54. 2009
    This paper analyses the costs and benefits of commissioning memory services for early diagnosis and intervention for dementia.
  20. pmc Early diagnosis of left ventricular diastolic dysfunction in diabetic patients: a possible role for natriuretic peptides
    Silvio Romano
    Cardiology, Department of Internal Medicine and Public Health, University of L Aquila, Italy
    Cardiovasc Diabetol 9:89. 2010
    ..The aim of the present study was to verify whether BNP might detect pre-clinical diastolic dysfunction (LVDD) in type-2 diabetic patients...
  21. pmc Early diagnosis of pancreatic cancer: neutrophil gelatinase-associated lipocalin as a marker of pancreatic intraepithelial neoplasia
    N Moniaux
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Br J Cancer 98:1540-7. 2008
    ..Given the need for biomarkers in the early diagnosis of pancreatic cancer, we investigated the expression of NGAL in tissues with the objective of examining if ..
  22. pmc The National Lung Screening Trial: overview and study design
    Denise R Aberle
    Center for Statistical Sciences, Brown University, Box G S121, 121 S Main St, 7th Floor, Providence, RI 02912, USA
    Radiology 258:243-53. 2011
    ..The NLST is such a trial. The rationale for and design of the NLST are presented...
  23. ncbi Cytologic and DNA-cytometric very early diagnosis of oral cancer
    D Maraki
    Department of Oral Surgery, Heinrich Heine University, Duesseldorf, Germany
    J Oral Pathol Med 33:398-404. 2004
    ..The aim of this study was to evaluate the diagnostic accuracy of exfoliative cytology (EC) and DNA-image cytometry applied to suspicious oral lesions compared with synchronous histology...
  24. doi Early diagnosis of novel SFTS bunyavirus infection by quantitative real-time RT-PCR assay
    Yulan Sun
    National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China
    J Clin Virol 53:48-53. 2012
    ..The clinical diagnosis is urgently needed to differentiate the disease from other infections...
  25. pmc Early diagnosis of Dengue infection using a commercial Dengue Duo rapid test kit for the detection of NS1, IGM, and IGG
    Seok Mui Wang
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Am J Trop Med Hyg 83:690-5. 2010
    ..65% and 98.75%, respectively. The assay is sensitive and highly specific. Detection of both NS1 and IgM by SD Duo gave comparable detection rate by either serology or RT-PCR...
  26. ncbi Early diagnosis of human immunodeficiency virus in infants using polymerase chain reaction on dried blood spots in Botswana's national program for prevention of mother-to-child transmission
    Tracy Creek
    Global AIDS Program, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Pediatr Infect Dis J 27:22-6. 2008
    ..Dried blood spot (DBS) polymerase chain reaction (PCR) provides a feasible method to assess PMTCT programs and identify HIV-infected children...
  27. pmc Early diagnosis of asthma in young children by using non-invasive biomarkers of airway inflammation and early lung function measurements: study protocol of a case-control study
    Kim D G van de Kant
    Department of Paediatric Pulmonology, Maastricht University Medical Centre MUMC, Maastricht, The Netherlands
    BMC Public Health 9:210. 2009
    ..In addition, aetiological factors, including gene polymorphisms and gene expression profiles, in relation to the development of asthma are studied...
  28. pmc Early detection and intervention evaluation for people at risk of psychosis: multisite randomised controlled trial
    Anthony P Morrison
    School of Psychological Sciences, University of Manchester, Manchester M13 9PL, UK
    BMJ 344:e2233. 2012
    ..To determine whether cognitive therapy is effective in preventing the worsening of emerging psychotic symptoms experienced by help seeking young people deemed to be at risk for serious conditions such as schizophrenia...
  29. ncbi Epidemiology of chronic kidney disease in the Kingdom of Saudi Arabia (SEEK-Saudi investigators) - a pilot study
    Abdulkareem O Alsuwaida
    Renal Division, King Saud University, Riyadh, Kingdom of Saudi Arabia
    Saudi J Kidney Dis Transpl 21:1066-72. 2010
    ..7%. Our pilot study demonstrated the feasibility of screening for CKD. Screening of high-risk individuals is likely to be the most cost-effective strategy to detect CKD patients...
  30. doi Timing the therapeutic window of opportunity in early rheumatoid arthritis: proposal for definitions of disease duration in clinical trials
    Karim Raza
    Division of Immunity and Infection, Rheumatology Research Group, University of Birmingham, Birmingham B15 2TT, UK
    Ann Rheum Dis 71:1921-3. 2012
  31. doi Level of agreement of the 1987 ACR and 2010 ACR/EULAR rheumatoid arthritis classification criteria: an analysis based on ESPOIR cohort data
    Bruno Fautrel
    Department of Rheumatology, Université Pierre et Marie Curie Sorbonne Universités, AP HP Assistance Publique Hôpitaux de Paris, Pitie Salpetriere Hospital, Paris, France
    Ann Rheum Dis 71:386-9. 2012
    ..In 2010, new classification criteria for rheumatoid arthritis (RA) were developed...
  32. doi Use of neutrophil count in early diagnosis and risk stratification of AMI
    Julia Meissner
    Department of Internal Medicine, University Hospital Basel, Switzerland
    Am J Med 124:534-42. 2011
    ..We hypothesized that neutrophil count might provide incremental value in the early diagnosis and risk stratification of AMI.
  33. doi Non-hospital DOT and early diagnosis of tuberculosis reduce costs while achieving treatment success
    K Pichenda
    International Health Section, Division of Public Health, Graduate School of Tokyo Medical and Dental University, Tokyo, Japan
    Int J Tuberc Lung Dis 16:828-34. 2012
    ..Treatment outcomes for the different DOT programmes as well as direct and indirect household costs and medical delivery costs for the treatment and care of 277 patients were examined...
  34. doi Early diagnosis of acute myocardial infarction in the elderly using more sensitive cardiac troponin assays
    Miriam Reiter
    Department of Internal Medicine, University Hospital, Petersgraben 4, CH 4031 Basel, Switzerland
    Eur Heart J 32:1379-89. 2011
    ..To examine the diagnostic accuracy of sensitive cardiac troponin (cTn) assays in elderly patients, since elevated levels with sensitive cTn assays were reported in 20% of elderly patients without acute myocardial infarction (AMI)...
  35. pmc Early diagnosis of peripheral nervous system involvement in Fabry disease and treatment of neuropathic pain: the report of an expert panel
    Alessandro P Burlina
    Neurological Unit, St Bassiano Hospital, Bassano del Grappa, Italy
    BMC Neurol 11:61. 2011
    ..Patients with Fabry disease often remain undiagnosed until severe complications involving the kidney, heart, peripheral nerves and/or brain have arisen...
  36. pmc Metabolomics as a novel approach for early diagnosis of pediatric septic shock and its mortality
    Beata Mickiewicz
    Bio NMR Center, Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada
    Am J Respir Crit Care Med 187:967-76. 2013
    ..Early recognition of septic shock and appropriate treatment increase survival rate; thus, developing new diagnostic tools may improve patients' outcomes...
  37. doi Referral strategies for early diagnosis of axial spondyloarthritis
    Martin Rudwaleit
    Endokrinologikum Berlin, Jägerstrasse 61, 10117 Berlin, Germany
    Nat Rev Rheumatol 8:262-8. 2012
  38. doi Early diagnosis of acute myocardial infarction in patients with pre-existing coronary artery disease using more sensitive cardiac troponin assays
    Miriam Reiter
    Department of Internal Medicine, University Hospital, Petersgraben 4, CH 4031 Basel, Switzerland
    Eur Heart J 33:988-97. 2012
    ..We sought to examine the diagnostic and prognostic utility of sensitive cardiac troponin (cTn) assays in patients with pre-existing coronary artery disease (CAD)...
  39. doi Comparison of serum creatinine and cystatin C for early diagnosis of contrast-induced nephropathy after coronary angiography and interventions
    Flavio Ribichini
    Department of Medicine, Division of Cardiology, University of Verona, Verona, Italy
    Clin Chem 58:458-64. 2012
    ..We investigated the diagnostic sensitivities, diagnostic specificities, and variations from baseline for serum creatinine and Cys in CIN...
  40. pmc Microscopic observation drug susceptibility assay (MODS) for early diagnosis of tuberculosis in children
    Dang Thi Minh Ha
    TB Department, Pham Ngoc Thach Hospital, Ho Chi Minh City, Vietnam
    PLoS ONE 4:e8341. 2009
    MODS is a novel liquid culture based technique that has been shown to be effective and rapid for early diagnosis of tuberculosis (TB). We evaluated the MODS assay for diagnosis of TB in children in Viet Nam...
  41. pmc The state of molecular biomarkers for the early detection of lung cancer
    Mohamed Hassanein
    Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt Ingram Cancer Center, Nashville TN 37232, USA
    Cancer Prev Res (Phila) 5:992-1006. 2012
  42. pmc Dynamics and constraints of early infant diagnosis of HIV infection in Rural Kenya
    Amin S Hassan
    Centre for Geographic Medicine Research, Kenya Medical Research Institute, Kilifi, Kenya
    AIDS Behav 16:5-12. 2012
    ..EID should be more closely aligned within PMTCT services, integrated with routine mother and child health (MCH) activities and its implementation more closely monitored...
  43. doi Evaluation of adhesion molecules CD64, CD11b and CD62L in neutrophils and monocytes of peripheral blood for early diagnosis of neonatal infection
    Ferah Genel
    Department of Pediatrics, Dr Behcet Uz Children s Hospital, Alsancak, Izmir, Turkey
    World J Pediatr 8:72-5. 2012
    This study was undertaken to assess the value of neutrophils CD11b, CD64, and CD62L for the early diagnosis of neonatal infection.
  44. doi Young people at ultra high risk for psychosis: a research update
    Alison R Yung
    Orygen Youth Health Research Centre, Centre for Youth Mental Health, University of Melbourne, Parkville, Victoria, Australia
    Early Interv Psychiatry 5:52-7. 2011
    ..The validation of the ultra high risk criteria led to a series of intervention studies in this population. The aim of this paper is to provide an overview of ultra high risk research...
  45. doi Conventional and molecular techniques for the early diagnosis of bacteraemia
    Michela Paolucci
    Department of Hematology and Oncology L e A Seragnoli, University of Bologna, St Orsola University Hospital, Bologna, Italy
    Int J Antimicrob Agents 36:S6-16. 2010
    ..This review examines the principal advantages and limitations of some traditional and molecular methods commercially available to help the microbiologist and the clinician in the management of bloodstream infections...
  46. doi Early diagnosis of ovarian carcinoma: is a solution in sight?
    Amelie M Lutz
    Department of Radiology, Bio X Program, Stanford University School of Medicine, 318 Campus Dr, Room E150, Stanford, CA 94305, USA
    Radiology 259:329-45. 2011
  47. doi A critical appraisal of the premotor symptoms of Parkinson's disease: potential usefulness in early diagnosis and design of neuroprotective trials
    Anthony E Lang
    University of Toronto, Toronto, Ontario, Canada
    Mov Disord 26:775-83. 2011
    ..This article will review the current status of premotor symptoms of Parkinson's disease and discuss their potential for early diagnosis and the design of neuroprotective trials.
  48. pmc Diagnosis of pulmonary tuberculosis in HIV-positive patients by microscopic observation drug susceptibility assay
    Dang Thi Minh Ha
    Pham Ngoc Thach Hospital, and Wellcome Trust Mamor Overseas Programme, Oxford University Clinical Research Unit, 120 Hung Vuong, District 5, Ho Chi Minh City, Vietnam
    J Clin Microbiol 48:4573-9. 2010
    The microscopic observation drug susceptibility assay (MODS) is a novel and promising test for the early diagnosis of tuberculosis (TB)...
  49. doi The 2010 American College of Rheumatology/European League Against Rheumatism classification criteria for rheumatoid arthritis: methodological report phase I
    Julia Funovits
    Division of Rheumatology, Medical University Vienna, Waehringer Guertel 18 20, Vienna, Austria
    Ann Rheum Dis 69:1589-95. 2010
  50. pmc CD16+ monocytes in breast cancer patients: expanded by monocyte chemoattractant protein-1 and may be useful for early diagnosis
    A L Feng
    Institute of Basic Medical Sciences Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Jinan, Shandong, China
    Clin Exp Immunol 164:57-65. 2011
    ..Collectively, our findings indicated that MCP-1 can expand CD14(+) CD16(+) monocytes in patients with breast cancer. Furthermore, the CD14(+) CD16(+) monocyte may be a useful indicator in early diagnosis of breast cancer.
  51. doi Validation of the 2010 ACR/EULAR classification criteria for rheumatoid arthritis: slight improvement over the 1987 ACR criteria
    Karin Britsemmer
    Department of Rheumatology, Jan van Breemen Research Institute I Reade, Amsterdam, The Netherlands
    Ann Rheum Dis 70:1468-70. 2011
    ..Recently, an American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) collaboration developed new classification criteria for rheumatoid arthritis (RA)...
  52. pmc Contributing to the early detection of Rett syndrome: the potential role of auditory Gestalt perception
    Peter B Marschik
    Institute of Physiology, IN spired, Developmental Physiology and Developmental Neuroscience, Center for Physiological Medicine, Medical University of Graz, Austria
    Res Dev Disabil 33:461-6. 2012
    ..This is important because clinical criteria related to speech and language development remain important for early identification of Rett syndrome...
  53. pmc Diagnostic performance of the ACR/EULAR 2010 criteria for rheumatoid arthritis and two diagnostic algorithms in an early arthritis clinic (REACH)
    Celina Alves
    Department of Rheumatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Ann Rheum Dis 70:1645-7. 2011
    ..An ACR/EULAR task force released new criteria to classify rheumatoid arthritis at an early stage. This study evaluates the diagnostic performance of these criteria and algorithms by van der Helm and Visser in REACH...
  54. doi Do family physicians' records fit guideline diagnosed COPD?
    Mieke Albers
    Department of Primary Care Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Fam Pract 26:81-7. 2009
    ..In family practice, chronic obstructive pulmonary disease (COPD) is usually not diagnosed until clinically apparent and of moderately advanced severity...
  55. doi Early diagnosis of abnormal development of preterm newborns: assessment instruments
    Rosana S Santos
    Universidade Federal do Rio de Janeiro UFRJ, Rio de Janeiro, RJ, Brazil
    J Pediatr (Rio J) 84:289-99. 2008
    ..To review the literature regarding screening psychomotor tests for the early identification of developmental problems...
  56. doi Prediction of psychosis in adolescents and young adults at high risk: results from the prospective European prediction of psychosis study
    Stephan Ruhrmann
    Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Strasse 62, 50924 Cologne, Germany
    Arch Gen Psychiatry 67:241-51. 2010
    ..Existing criteria need improvement in terms of specificity and individual risk assessment to allow for better targeted and earlier interventions...
  57. pmc YKL-40: a novel prognostic fluid biomarker for preclinical Alzheimer's disease
    Rebecca Craig-Schapiro
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Biol Psychiatry 68:903-12. 2010
    ..Therefore, biomarkers that detect AD pathology in its early stages and predict dementia onset and progression will be invaluable for patient care and efficient clinical trial design...
  58. pmc Early infant HIV-1 diagnosis programs in resource-limited settings: opportunities for improved outcomes and more cost-effective interventions
    Andrea L Ciaranello
    Division of Infectious Disease, Massachusetts General Hospital, and Center for AIDS Research, Harvard Medical School, Boston, MA, USA
    BMC Med 9:59. 2011
  59. pmc Implementing services for Early Infant Diagnosis (EID) of HIV: a comparative descriptive analysis of national programs in four countries
    Anirban Chatterjee
    Department of Health and Nutrition, UNICEF Ghana, Accra, Ghana
    BMC Public Health 11:553. 2011
    ..The goal of this multi-country review was to examine when and where HIV-exposed infants and children are being diagnosed, and whether the EID service is being maximally utilized to improve health outcomes for HIV-exposed children...
  60. doi Engrailed-2 (EN2): a tumor specific urinary biomarker for the early diagnosis of prostate cancer
    Richard Morgan
    Postgraduate Medical School, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom
    Clin Cancer Res 17:1090-8. 2011
    ..We have assessed the diagnostic potential of Engrailed-2 (EN2) protein, a homeodomain-containing transcription factor expressed in PC cell lines and secreted into the urine by PC in men...
  61. pmc Lipoprotein(a) as a cardiovascular risk factor: current status
    Børge G Nordestgaard
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, DK 2730 Herlev, Denmark
    Eur Heart J 31:2844-53. 2010
    ..The aims of the study were, first, to critically evaluate lipoprotein(a) [Lp(a)] as a cardiovascular risk factor and, second, to advise on screening for elevated plasma Lp(a), on desirable levels, and on therapeutic strategies...
  62. doi Genome-wide microRNA profiles identify miR-378 as a serum biomarker for early detection of gastric cancer
    Hanshao Liu
    National Engineering Center for Biochip at Shanghai, Shanghai, PR China
    Cancer Lett 316:196-203. 2012
    ..73% specificity in discriminating GC patients from healthy controls. Collectively, these data support our contention that serum miR-378 has strong potential as a novel noninvasive biomarker in gastric cancer detection...
  63. pmc Early diagnosis of Alzheimer's disease using cortical thickness: impact of cognitive reserve
    Olivier Querbes
    INSERM, Imagerie cérébrale et handicaps neurologiques UMR 825, F 31059 Toulouse, France
    Brain 132:2036-47. 2009
    ..Brain atrophy measured by magnetic resonance structural imaging has been proposed as a surrogate marker for the early diagnosis of Alzheimer's disease...
  64. pmc Long delays and missed opportunities in diagnosing smear-positive pulmonary tuberculosis in Kampala, Uganda: a cross-sectional study
    Ibrahim Sendagire
    Public Health Department, Kampala City Council, Kampala, Uganda
    PLoS ONE 5:e14459. 2010
  65. pmc Early detection of ovarian cancer
    Donna Badgwell
    Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Dis Markers 23:397-410. 2007
    ..The development of technologies that measure multiple serum markers simultaneously, linked to the creation of statistical methods that enhance sensitivity without sacrificing specificity hold great promise...
  66. pmc Early right ventricular systolic dysfunction in patients with systemic sclerosis without pulmonary hypertension: a Doppler Tissue and Speckle Tracking echocardiography study
    Sebastian Schattke
    Universitatsmedizin Berlin, Medical Clinic for Cardiology and Angiology, Charite Campus Mitte, Chariteplatz 1, 10117 Berlin, Germany
    Cardiovasc Ultrasound 8:3. 2010
    ..The aim of this study was to evaluate IVA as an early parameter for the detection of right ventricular (RV) systolic dysfunction in patients with systemic sclerosis (SSc) without pulmonary hypertension...
  67. pmc Performance of detecting IgM antibodies against enterovirus 71 for early diagnosis
    Feihai Xu
    National Institute of Diagnostics and Vaccine Development in Infectious Disease, Xiamen University, Xiamen, China
    PLoS ONE 5:e11388. 2010
    ..IgM antibody against EV71 had been established for years, however, the performance of the methods in the very early diagnosis of EV71 infection had not been fully evaluated, which is especially meaningful because of the short ..
  68. doi Retrospective evaluation of revised criteria for the diagnosis of Alzheimer's disease using a cohort with post-mortem diagnosis
    Celeste A de Jager
    Department of Physiology, Anatomy and Genetics, University of Oxford, UK
    Int J Geriatr Psychiatry 25:988-97. 2010
    ..We aimed to evaluate the new predementia-AD criteria through their retrospective application to the OPTIMA cohort with post-mortem (PM) confirmed diagnoses...
  69. ncbi Epidemiology, clinical features, laboratory investigations and early diagnosis of dengue fever in adults: a descriptive study in Sri Lanka
    S A M Kularatne
    Department of Medicine, Faculty of Medicine, Peradeniya University, Peradeniya, Sri Lanka
    Southeast Asian J Trop Med Public Health 36:686-92. 2005
    ..was conducted to identify the epidemiology, clinical features, laboratory investigations and markers for early diagnosis of acute dengue virus infection in adults...
  70. pmc Biological markers for early detection and pharmacological treatment of Alzheimer's disease
    Harald Hampel
    Department of Psychiatry, Ludwig Maximilian University Munich, Alzheimer Memorial Center, Munich, Germany
    Dialogues Clin Neurosci 11:141-57. 2009
    ..As a perspective, the important role of biomarkers in the development of innovative drug treatments for AD and the related regulatory process is discussed...
  71. ncbi Painful diabetic neuropathy: epidemiology, natural history, early diagnosis, and treatment options
    Aristidis Veves
    Microcirculation Laboratory, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Pain Med 9:660-74. 2008
    ..To facilitate the clinician's understanding of the basis and treatment of painful diabetic neuropathy (PDN)...
  72. doi Anti-CCP Antibody, a Marker for the Early Detection of Rheumatoid Arthritis
    Walther J van Venrooij
    Department of Biomolecular Chemistry, Radboud University, Nijmegen, The Netherlands
    Ann N Y Acad Sci 1143:268-85. 2008
    ..In most cases this will lead to the formation of pannus tissue, ultimately leading to joint destruction. Early diagnosis, coupled with aggressive use of disease-modifying antirheumatic drugs, has been shown to have a favorable ..
  73. ncbi Comparison of brain natriuretic peptide (BNP) and amino-terminal ProBNP for early diagnosis of heart failure
    Michele Emdin
    CNR Institute of Clinical Physiology, Cardiovascular Medicine Department and Cardiovascular Endocrinology Laboratory, Pisa, Italy
    Clin Chem 53:1289-97. 2007
    ..We compared the diagnostic accuracy of brain natriuretic peptide (BNP) and amino-terminal proBNP (NT-proBNP) for diagnosis of preclinical and mild heart failure (HF)...
  74. pmc Real-time PCR with serum samples is indispensable for early diagnosis of acute Q fever
    Peter M Schneeberger
    Jeroen Bosch Hospital, Department of Medical Microbiology and Infection Control, P O Box 90153, 5200 ME s Hertogenbosch, The Netherlands
    Clin Vaccine Immunol 17:286-90. 2010
    ..We conclude that real-time PCR with serum samples is indispensable for early diagnosis of acute Q fever. C. burnetii DNA becomes undetectable in serum as the serological response develops.
  75. pmc Evaluation of nonstructural 1 antigen assays for the diagnosis and surveillance of dengue in Singapore
    Kwoon Yong Pok
    National Environment Agency, Environmental Health Institute, Singapore, Singapore
    Vector Borne Zoonotic Dis 10:1009-16. 2010
    ..Nonetheless, it remains a useful assay for the early detection of dengue and hence could play an important role in routine surveillance efforts to control dengue outbreaks in Singapore...
  76. doi Biological markers of acute kidney injury
    Edward D Siew
    Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University School of Medicine, 1161 21 Avenue South, Medical Center North S 3223, Nashville, TN 37232, USA
    J Am Soc Nephrol 22:810-20. 2011
    ..Here, we discuss efforts to address these barriers and further ascertain the clinical value of new markers...
  77. doi Copeptin improves early diagnosis of acute myocardial infarction
    Till Keller
    Department of Medicine II, University Medical Center of the Johannes Gutenberg University, Mainz, Germany
    J Am Coll Cardiol 55:2096-106. 2010
    ..Early identification of myocardial infarction in chest pain patients is crucial to identify patients at risk and to maintain a fast treatment initiation...
  78. pmc Neutrophil gelatinase-associated lipocalin: a promising biomarker for human acute kidney injury
    Prasad Devarajan
    Cincinnati Children s Hospital Medical Center, University of Cincinnati School of Medicine, Cincinnati, OH 45229 3039, USA
    Biomark Med 4:265-80. 2010
  79. pmc Emerging applications of nanomedicine for the diagnosis and treatment of cardiovascular diseases
    Biana Godin
    Department of Nanomedicine and BioMedical Engineering, The University of Texas Health Science Center at Houston, 1825 Pressler, Suite 537, Houston, TX 77030, USA
    Trends Pharmacol Sci 31:199-205. 2010
    ..Specifically, we discuss the use of nanoparticles for molecular imaging and advanced therapeutics, specially designed drug eluting stents and in vivo/ex vivo early detection techniques...
  80. ncbi Cost-effectiveness of routine rapid human immunodeficiency virus antibody testing before DNA-PCR testing for early diagnosis of infants in resource-limited settings
    Nicolas A Menzies
    Centers for Disease Control and Prevention CDC, Global AIDS Program, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, CDC, Atlanta, GA, USA
    Pediatr Infect Dis J 28:819-25. 2009
    Infants born to HIV-infected women should receive HIV testing to allow early diagnosis and treatment. Recommendations for resource-limited settings stress laboratory-based virologic assays...
  81. ncbi Detecting dementia: novel neuropsychological markers of preclinical Alzheimer's disease
    Andrew D Blackwell
    Department of Psychiatry, University of Cambridge, Cambridge, UK
    Dement Geriatr Cogn Disord 17:42-8. 2004
    ..Using these tests, a simple algorithm is described for calculating, with 100% accuracy for this sample of 40 patients, the probability that an individual with mild memory impairments will go on to receive a diagnosis of probable AD...
  82. pmc Occurrence of autoantibodies to annexin I, 14-3-3 theta and LAMR1 in prediagnostic lung cancer sera
    Ji Qiu
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Clin Oncol 26:5060-6. 2008
  83. pmc Costs and consequences of the US Centers for Disease Control and Prevention's recommendations for opt-out HIV testing
    David R Holtgrave
    Department of Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
    PLoS Med 4:e194. 2007
    ..In this paper, I estimate the costs and public health impact of opt-out HIV testing relative to testing accompanied by client-centered counseling, and relative to a more targeted counseling and testing strategy...
  84. doi Urinary neutrophil gelatinase-associated lipocalin (NGAL) as an early marker of acute kidney injury in critically ill multiple trauma patients
    Konstantinos Makris
    Clinical Biochemistry Department, KAT General Hospital, Kiffissia, Athens, Greece
    Clin Chem Lab Med 47:79-82. 2009
    ..The aim of this study was to evaluate urinary NGAL levels as a predictor of early AKI (first 5 days after injury) in multi-trauma patients...
  85. doi Urinary biomarkers for acute kidney injury: perspectives on translation
    Steven G Coca
    Section of Nephrology, VAMC and Yale University School of Medicine, Clinical Epidemiology Research Center, West Haven, CT 06516, USA
    Clin J Am Soc Nephrol 3:481-90. 2008
    ..It is likely that a panel of biomarkers, rather than a single biomarker, will be needed to perform extremely well in these three situations...
  86. ncbi National type 2 diabetes prevention programme in Finland: FIN-D2D
    Timo Saaristo
    Finnish Diabetes Association, Tampere, Finland
    Int J Circumpolar Health 66:101-12. 2007
    ..comprises 3 concurrent strategies for prevention: the population strategy, the high-risk strategy and the strategy of early diagnosis and management. The article describes the implementation strategy for the prevention programme for T2D.
  87. doi Circulating microRNAs as novel biomarkers for the early diagnosis of acute coronary syndrome
    J C Deddens
    Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Heidelberglaan 100, Room G02 523, 3584, CX, Utrecht, The Netherlands
    J Cardiovasc Transl Res 6:884-98. 2013
    ..For that reason, miRNAs are proposed as diagnostic biomarkers for various diseases. Early diagnosis of acute coronary syndrome (ACS), especially non-ST elevated myocardial infarction and unstable angina ..
  88. pmc The ADDITION-Cambridge trial protocol: a cluster -- randomised controlled trial of screening for type 2 diabetes and intensive treatment for screen-detected patients
    Justin B Echouffo-Tcheugui
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge, UK
    BMC Public Health 9:136. 2009
    ..Population-based screening and early treatment for type 2 diabetes could reduce this growing burden. However, the benefits of such a strategy remain uncertain...
  89. doi Impact of hallmark autoantibody reactivity on early diagnosis in scleroderma
    Pia Moinzadeh
    Centre for Rheumatology, Royal Free Hospital and UCL Medical School, London, UK
    Clin Rev Allergy Immunol 43:249-55. 2012
    ..Duration of antecedent Raynaud's phenomenon differs between disease subsets and scleroderma-specific ANA patterns...
  90. pmc The early clinical features of dengue in adults: challenges for early clinical diagnosis
    Jenny G H Low
    Communicable Diseases Centre, Tan Tock Seng Hospital, Singapore, Singapore
    PLoS Negl Trop Dis 5:e1191. 2011
    ..The clinical features of dengue in different age groups have not been well examined, especially in the context of early clinical diagnosis...
  91. doi Serum intestinal fatty acid binding protein level for early diagnosis and prediction of severity of necrotizing enterocolitis
    Cumhur Aydemir
    Department of Neonatology, Zekai Tahir Burak Maternity Hospital, Ankara, Turkey
    Early Hum Dev 87:659-61. 2011
    ..In this study, we aimed to investigate the value of serum I-FABP in early diagnosis and predicting severity of NEC.
  92. doi Leptospirosis diagnosis by immunocapture polymerase chain reaction: a new tool for early diagnosis and epidemiologic surveillance
    Ilana Teruszkin Balassiano
    Laboratório de Zoonoses Bacterianas, Centro de Referência Nacional para Leptospirose, WHO PAHO Centro Colaborador para Leptospirose, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil
    Diagn Microbiol Infect Dis 74:11-5. 2012
    ..IC-PCR proved to be specific to Leptospira and is a promising tool for early diagnosis of leptospirosis, providing additional information about the infecting serovar or serogroup.
  93. doi Updates of lifetime costs of care and quality-of-life estimates for HIV-infected persons in the United States: late versus early diagnosis and entry into care
    Paul G Farnham
    Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA Atlanta Veterans Affairs Medical Center, Atlanta, GA Emory University School of Medicine, Atlanta, GA and Emory University Rollins School of Public Health, Atlanta, GA
    J Acquir Immune Defic Syndr 64:183-9. 2013
    ..Updated estimates were used to analyze the effects of late versus early diagnosis/entry on US lifetime care costs, quality-of-life estimates, and HIV transmissions.
  94. doi Dengue NS1 antigen detection: a useful tool in early diagnosis of dengue virus infection
    S Datta
    Department of Clinical Microbiology, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi 110 060, India
    Indian J Med Microbiol 28:107-10. 2010
    ..This study was undertaken to evaluate the efficacy of NS1 antigen (Ag) assay as an early marker for dengue virus (DV) infection...
  95. doi Performance of the 2010 ACR/EULAR criteria for rheumatoid arthritis: comparison with 1987 ACR criteria in a very early synovitis cohort
    Mohammed Z Cader
    Department of Rheumatology, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK
    Ann Rheum Dis 70:949-55. 2011
    ..This study therefore assesses the performance of these new criteria in patients with early synovitis...
  96. pmc Urinary biomarkers in the early diagnosis of acute kidney injury
    W K Han
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Kidney Int 73:863-9. 2008
    A change in the serum creatinine is not sensitive for an early diagnosis of acute kidney injury...
  97. doi Altered expression levels of miRNAs in serum as sensitive biomarkers for early diagnosis of traumatic injury
    Yi Zhang
    Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi an 710032, PR China
    J Cell Biochem 112:2435-42. 2011
    ..Our data suggest that serum miR-9 may serve as promising biomarker for traumatic injury with high sensitivity. Furthermore, these findings may help to elucidate the complex network which mediates stress response to traumatic injury...
  98. pmc Early diagnosis of in utero and intrapartum HIV infection in infants prior to 6 weeks of age
    Rivka R Lilian
    Paediatric HIV Diagnostic Syndicate, Wits Health Consortium, Johannesburg, South Africa
    J Clin Microbiol 50:2373-7. 2012
    ..CAP/CTM was the only assay with 100% specificity at all ages. Testing at birth versus 6 weeks of age identifies a higher total number of HIV-infected infants, irrespective of the assay...
  99. doi Olfactory detection of prostate cancer by dogs sniffing urine: a step forward in early diagnosis
    Jean Nicolas Cornu
    Department of Urology, Tenon Hospital, Assistance Publique Hopitaux de Paris, University Paris VI, Paris, France
    Eur Urol 59:197-201. 2011
    ..Volatiles organic compounds (VOCs) in urine have been proposed as cancer biomarkers...
  100. pmc Uptake of provider-initiated HIV testing and counseling among women attending an urban sexually transmitted disease clinic in South Africa - missed opportunities for early diagnosis of HIV infection
    Ayesha B M Kharsany
    Centre for the AIDS Programme of Research in South Africa, University of KwaZulu Natal, Private Bag 7 Congella, Durban 4013, South Africa
    AIDS Care 22:533-7. 2010
    ..patients await health care services, such as an STD clinic, failure to implement PITC is a missed opportunity for patients to benefit from counseling, prevention, early diagnosis, and referral into care and treatment for HIV infection.
  101. pmc Early diagnosis of candidemia in intensive care unit patients with sepsis: a prospective comparison of (1→3)-β-D-glucan assay, Candida score, and colonization index
    Brunella Posteraro
    Institute of Microbiology, Universita Cattolica del Sacro Cuore, Rome, Largo F Vito 1, 00168, Italy
    Crit Care 15:R249. 2011
    The culture-independent serum (1→3)-β-D-glucan (BG) detection test may allow early diagnosis of invasive fungal disease, but its clinical usefulness needs to be firmly established...

Research Grants82

  1. Development and Validation of a Panel of Breast Cancer for the Early Diagnosis of
    Development and validation of a panel of breast cancer autoantigens for the early diagnosis of breast cancer Abstract Detection of the early stages of breast cancer is one of the pillars of successful therapy and the identification of ..
  2. Novel PET imaging agents for early diagnosis of plaque deposition in Alzheimer's
    Padmakar Kulkarni; Fiscal Year: 2010
    ..amyloid burden in subjects with Alzheimer's disease (AD) and also would allow for specific and accurate early diagnosis and disease progression and disease modifying treatments...
  3. Novel diagnostic and safety biomarkers of liver injury and hepatotoxicity
    Stanislav I Svetlov; Fiscal Year: 2010
    ..of the development of novel liver specific biomarkers which are easily detected in serum and can be used for early diagnosis of patients with liver injury and aid in monitoring of potential liver toxicity in patients during drug ..
  4. Drug Interactions at the Human Blood-Brain Barrier
    Jashvant D Unadkat; Fiscal Year: 2010
    ..Chemist/biologist collaborations facilitating tool development;05-AG-103* Imaging and Fluid Biomarkers for Early Diagnosis and Progression of Aging-related Diseases and Conditions including Neurodegenerative Diseases...
  5. Diagnosis of Subglottic Stenosis and Edema in Neonates Using OCT
    Brian Wong; Fiscal Year: 2013
    ..b>Early diagnosis of disease onset may lead to reduction in the incidence of tracheostomy and other airway complications...
  6. Robust Peptide-Based Diagnostics of Botulinum Toxins
    John E Mueller; Fiscal Year: 2012
    ..therapeutic and prophylactic measures in the event of an intentional release, it is critical that rapid and early diagnosis of neurotoxin intoxication in humans be possible...
  7. Early Disease Biomarkers of PCB-exposed Human Population
    Sisir K Dutta; Fiscal Year: 2010
    ..for PCB induced diseases through gene expression studies that can be used globally in the future for early diagnosis of diseases in humans following environmental stress...
  8. Aberrant DNA Methylation of MicroRNA Genes in Hepatocellular Carcinoma (HCC)
    Jing Shen; Fiscal Year: 2012
    ..These methylation markers have potential clinical applications to improve risk assessment, early diagnosis and prognostic prediction, and may even possibly improve treatment because of the reversible nature of ..
  9. Multimodal Retinal Functional Imaging for Diabetic Retinopathy
    Hao F Zhang; Fiscal Year: 2013
    ..imaging technology based on PAOM and OCT/ODT can provide comprehensive functional information for the early diagnosis of DR before clinical signs occur in the oxygen induced retinopathy (OIR) rat model...
    Kinga Szigeti; Fiscal Year: 2013
    ..Our long term goal is to identify genetic variants that may serve as biomarkers for early diagnosis and/or may suggest novel targets for therapeutic intervention...
  11. Proteome Bead-Display for Discovery of Tumor Antigens
    Mark Lim; Fiscal Year: 2013
    ..In addition to use in early diagnosis, such TAAs have great value in developing anti-cancer vaccines and potentially guiding individualized patient ..
  12. Cicatricial Alopecia Research Symposium 2011: Lipids, Inflammation &Stem Cells
    Pratima Karnik; Fiscal Year: 2011
    ..inflammation or stem cells, and the second, focused on the application of these themes to the pathogenesis, early diagnosis, and novel treatments for cicatricial alopecia...
  13. In utero programming of the dopamine system: behavior, neuroanatomy &epigenetics
    Teresa M Reyes; Fiscal Year: 2013
    ..disabilities are poorly understood and warrant further investigation, as this knowledge is critical for early diagnosis and intervention...
  14. Biomarker Profiles for Early Diagnosis of Sepsis in Neonates
    JAMES PRESTON MAPES; Fiscal Year: 2011
  15. CTRIP: Molecular phenotypes of rapidly progressive idiopathic pulmonary fibrosis
    Galen B Toews; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Early diagnosis of Idiopathic Pulmonary Fibrosis (IPF) is key to providing the appropriate treatment for this incurable ..
  16. Inflammation and Sub-Clinical Renal Damage in Cocaine-Dependent African Americans
    ..and to design community-level clinical trials to reduce cocaine- related morbidity and mortality through early diagnosis and treatment o renal consequences of dependency...
  17. Identification of Biomarkers for Early Detection of Renal Cell Carcinoma
    Othon Iliopoulos; Fiscal Year: 2012
    ..b>Early diagnosis while the disease is still localized increases the rate of survival to close to 50-95%...
  18. Osteoarthritis: Identification of Novel Imaging Biomarkers via 23Na/1H MRI at 7 T
    Gregory Chang; Fiscal Year: 2013
    ..scientists'understanding of OA pathogenesis, and suggest a potential noninvasive means for early diagnosis and more accurate monitoring/prediction of disease progression...
  19. High Throughput Screening of the Autoimmune Epitome
    Nancy J Olsen; Fiscal Year: 2010
    ..Using this as a model system, it is hoped that other autoimmune diseases will benefit from early diagnosis and treatment.
  20. Identification and Validation of Alcohol Biomarker Signatures by Proteomics
    Emanuel Rubin; Fiscal Year: 2010
    ..b>Early diagnosis of this condition by specific biomarkers will offer the opportunity for treatment and prevention of heart ..
  21. Health Information Technology for Chronic Kidney Disease Management
    Lipika Samal; Fiscal Year: 2013
    ..HIT systems can prompt early diagnosis of CKD and can help physicians to stratify patients according to risk of progression to ESRD...
  22. TAM receptor tyrosine kinases in inflammatory bowel disease
    Carla Rothlin; Fiscal Year: 2013
    ..Additionally, non-invasive diagnostic approaches need to be developed to facilitate the early diagnosis and therapeutic management of this chronic disease...
  23. Mechanisms of Peripheral Induction of T-Cell Tolerance
    ..future clinical trials to determine if self p:MHCII tetramer-based cell enrichment can be used as a tool for early diagnosis of diabetes or to monitor the efficacy of immunotherapy...
    James G Fujimoto; Fiscal Year: 2012
    ..for cellular resolution endoscopy is a longstanding challenge in biomedical imaging and promises to improve early diagnosis of cancer...
  25. Target discovery and immunoassay for diagnosis of invasive aspergillosis
    Thomas R Kozel; Fiscal Year: 2013
    ..A major cause of treatment failure is the difficulty in obtaining an early diagnosis that would facilitate timely antifungal therapy. Early diagnosis can markedly improve survival...
  26. An Innovative Endoscopic Instrument with Full-Field Viewing and Intelligent Imagi
    STEVEN YI; Fiscal Year: 2010
    ..Aside from early stage prevention, effective, low cost, and comfortable early diagnosis technologies are in great need to improve the situation...
  27. Early Pathogenesis of Cystic Fibrosis Related Diabetes
    Andrew W Norris; Fiscal Year: 2013
    ..Although the application focuses on early disease pathophysiology, it also has great potential for identifying blood biomarkers for early diagnosis of patients at risk for CFRD.
  28. Multifunctional nanoformulations for diagnostic imaging of atherosclerosis
    Alexander B Sigalov; Fiscal Year: 2012
    ..proposed research will result in the development of novel imaging techniques that could substantially improve early diagnosis and treatment of atherosclerosis, allowing for diagnosis before symptoms occur, identification of those ..
  29. Proteomic Identification of Actionable Biomarkers in Rheumatoid Arthritis
    William H Robinson; Fiscal Year: 2010
    ..A test for the early diagnosis of RA is therefore warranted, as early diagnosis would enable the identification of patients with ..
  30. The Biomechanics of the Human Posterior Sclera: Effects of Age, Sex, and Glaucoma
    Thao D Nguyen; Fiscal Year: 2013
    ..knowledge of the mechanical behavior of these structures will advance understanding of glaucoma injury, its early diagnosis, and prevention of the blindness caused by the disorder...
  31. Novel Role of a Nucleoporin Gene in Atrial Fibrillation, the Most Common Cardiac
    Qing Kenneth Wang; Fiscal Year: 2013
    ..These studies may lead to early diagnosis of AF patients with NUP155 mutations, and new and improved interventions and therapy for AF by targeting ..
  32. Novel Immunodeficiency caused by TFRC Mutation
    RAIF SALIM GEHA; Fiscal Year: 2013
    ..basis and pathogenesis of TFRC deficiency has important prognostic and therapeutic implications, including early diagnosis by flow cytometric analysis of cord blood lymphocytes for increased TfR1 surface expression, early ..
  33. Technical Development of Quantitative Biomarkers of Fatty Liver Disease with MRI
    Scott B Reeder; Fiscal Year: 2013
    ..The overall goal of this proposal is to develop and validate non-invasive quantitative methods for early diagnosis and quantitative grading of Non-Alcoholic Fatty Liver Disease (NAFLD), using magnetic resonance imaging (MRI)...
  34. Molecular mechanism of diet induced carcinogenesis
    Samson T Jacob; Fiscal Year: 2013
    ..of liver cancer in response to this dietary deficiency and (b) identification of novel molecular targets for early diagnosis and epigenetic therapy of liver cancer...
  35. Newborn screening for identification &prospective followup of infants with SMA
    Kathryn J Swoboda; Fiscal Year: 2013
    ..Finally, the investigators will evaluate the psychosocial impact of early diagnosis on SMA infants and their families...
  36. Longitudinal Studies of Autism Spectrum Disorders: 2 to 23
    Catherine Lord; Fiscal Year: 2012
    ..One hundred eighty seven out of 213 original children currently remain in the Early Diagnosis study initially funded by NIMH and NICHD. These children (i.e...
  37. Measuring Altered Social Behavior in Neurodegenerative Disease
    Katherine P Rankin; Fiscal Year: 2013
    ..resulting battery will 1) operationalize the social criteria for frontotemporal lobar degeneration to improve early diagnosis, 2) identify characteristic patterns of social function in other dementias, 3) provide a valid, normed ..
  38. EGFRvIII in Pancreatic Cancer
    Maneesh Jain; Fiscal Year: 2010
    ..There is an urgent need to identify novel biomarkers for early diagnosis and targets for therapeutic interventions...
  39. Gender Effects on Remodeling of Lipid and Sarcomere Dynamics in Hypertrophy
    E Douglas Lewandowski; Fiscal Year: 2013
    ..are to elucidate mechanisms for reprogramming cardiac lipid dynamics that affect heart function, thereby identifying strategies for early diagnosis and gender specific-treatment protocols to mitigate the development of cardiomyopathy.
  40. Using Genetics For Early Phenotyping &Prevention of Hypertrophic Cardiomyopathy
    Christine E Seidman; Fiscal Year: 2013
    ..efforts, we will begin to reshape the clinical paradigm for treating adult-onset genetic disorders, based on early diagnosis, mechanistic insight, and disease modification...
  41. Comparative effectiveness of Brain Imaging and Blood Biomarkers in Alzheimer??s d
    Orly Lazarov; Fiscal Year: 2010
    ..biomarkers in the same subjects to evaluate their comparative effectiveness at being able to provide for the early diagnosis or for following the progression of the disease...
  42. Mechanisms of Early Life Stress-Induced Endothelial Dysfunction
    Dao Ho; Fiscal Year: 2013
    ..mechanisms of ELS-induced endothelial dysfunction and vascular pathology in order to define novel pathways of early diagnosis and intervention of vascular disease...
  43. Phase-contrast enhanced X-ray imaging system for small joints of hand
    Thomas J Beck; Fiscal Year: 2010
    ..Recent RA research shows that early aggressive therapy is most effective, making early diagnosis essential. Currently the early subtle tissue effects of RA are best imaged with MRI and ultrasound...
  44. Stable isotopomer analysis of anabolic metabolic pathways in breast cancer
    Andrew N Lane; Fiscal Year: 2010
    ..Application of this approach to a clinical setting will set the stage for identifying sets of markers for early diagnosis, prognosis and ultimately drug responses.
  45. Near-Infrared Fluorescent Choline Kinase Inhibitors for Cancer Imaging and Therap
    SEAN ARLAUCKAS; Fiscal Year: 2013
    ..Although early diagnosis improves the prognosis for these patients, there is a shortage of non-invasive methods to identify biomarkers ..
  46. Characterization of the Plasma Proteome in Mouse Models of Colon Cancer
    Kenneth E Hung; Fiscal Year: 2010
    ..b>Early diagnosis of colorectal cancer by colonoscopy increases the probability of survival...
  47. Metformin as a novel chemopreventive agent for prostate cancer
    Xin Li; Fiscal Year: 2013
    ..b>Early diagnosis and prevention are critical to limit the impact of this disease...
  48. Recombinase Polymerase Amplification for Point-of-Care Diagnosis of Infant HIV-1
    DAVID SCOTT BOYLE; Fiscal Year: 2013
    ..Fortunately, early diagnosis and treatment of infected infants significantly slows disease progression and improves survival...
  49. Effect of Manganese Exposure on GABA and Glutamate in Human Brains by MRS
    Ulrike Dydak; Fiscal Year: 2010
    ..resemble those in idiopathic Parkinson's disease and usually become progressive and irreversible, making early diagnosis crucial for prevention of Mn intoxication in the occupational and environmental setting...
  50. The Aging Kidney in HIV-Infection: biomarkers for early detection of injury
    Michael G Shlipak; Fiscal Year: 2013
    ..It is widely agreed that the key strategy to prevent the complications of kidney disease is early diagnosis and provision of care...
  51. T1D:Investigating the Gut Microbiome, Urinary Proteome and Metabolome
    Ramana Madupu; Fiscal Year: 2011
    ..is to advance non-invasive clinical tests by applying novel molecular methods to correlate disease status for early diagnosis and prediction of T1D onset, setting the stage for potential therapies or intervention strategies...
  52. Transcriptomics in Traumatic Brain Injury: Relationship to Brain Oxygenation and
    Ava M Puccio; Fiscal Year: 2013
    ..critical care team, and the use of innovative technology, such as brain oxygenation monitoring may assist in early diagnosis and intervention...
  53. Hepatic Steatosis and the Lipid Metabolome
    GHULAM A S ANSARI; Fiscal Year: 2012
    ..is to elucidate the mechanisms leading to fatty liver, develop a biomarker signature of fatty liver to aid early diagnosis, and identify molecular targets for intervention at this early and reversible stage of liver diseases...
  54. Point-of-Care Diagnostic Assay for Direct Detection of Pathogenic Leptospira
    Jeffrey Smith; Fiscal Year: 2010
    ..the initial presentation of the infection is often that of non-specific viral infections, such as influenza, early diagnosis and treatment is infrequent...
  55. Monitoring of Stem Cell Engraftment in Arthritic Joints with MR Imaging
    ..this project is to develop a non-invasive and clinically applicable MR imaging technique, which provides an early diagnosis of complications of the engraftment process of matrix associated stem cell implants (MASI)...
  56. Novel therapeutics for alcoholic hepatitis - Cleveland Translational Component
    Laura E Nagy; Fiscal Year: 2013
    ..and liver function and b) urinary analysis of sensitive biomarkers of kidney function which would allow for early diagnosis and treatment of kidney failure in patients with AH...
  57. Molecular pathways leading to chronic graft dysfunction
    VALERIA RAQUEL MAS; Fiscal Year: 2012
    ..in kidney transplant patients will allow the identification and use of biomarkers in non-invasive assays for early diagnosis and the recognition of possible therapeutic options through the discovery of causal mechanisms...
  58. Functional interactions among retinoschisin and its binding partners
    GLADYS Y KO; Fiscal Year: 2013
    ..Because XLRS progression and severity is highly variable, early diagnosis and potential clinical intervention is very challenging...
  59. 18F-Mefway PET for Human Aging and Alzheimer's Disease
    Jogeshwar Mukherjee; Fiscal Year: 2013
    ..goal is to develop noninvasive imaging methods of positron emission tomography (PET) that will aid in the early diagnosis of these disorders and may therefore be useful in treatment planning...
  60. Extracellular Sulfatases As Novel Biomarkers For Early Detection of Cancer
    Joanna Phillips; Fiscal Year: 2013
    ..Our investigation of novel SULF-based biomarkers could lead to ELISAs for the early diagnosis of NSCLC and malignant astrocytoma and could become a new basis for patient management...
  61. Protein Biomarkers of Gastric Cancer
    Victor E Reyes; Fiscal Year: 2010
    ..of this project is to implement high throughput technology to identify proteins that could become candidate biomarker signatures that would aid in early diagnosis of Helicobacter pylori infection and gastric cancer development.
  62. Grafting DNA Codes on Paper for Rapid, Low-Cost, and Sensitive Meningitis Diagnos
    Xiujun Li; Fiscal Year: 2013
    ..of meningitis, a simple, low-cost, highly-sensitive device and method are greatly needed for immediate and early diagnosis of meningitis in resource-poor settings...
  63. Genome Transplant Dynamics: non-invasive sequencing-based diagnosis of rejection
    HANNAH AUGUSTA contact VALANTINE; Fiscal Year: 2010
    ..by applicant): Our goal is to develop and test a novel donor-specific, genomic approach to the non-invasive, early diagnosis of rejection and graft dysfunction after solid organ transplantation, and addresses two targeted thematic ..
  64. Novel Receptor-Targeting Theranostic Peptides for Prostate Cancer
    Yubin Miao; Fiscal Year: 2013
    ..Unfortunately, no curative treatment exists for metastatic prostate cancer. Early diagnosis of prostate cancer followed by prompt surgical removal provides patients the best opportunities for cures or ..
  65. Combined raman spectroscopy-optical tomagraphy for complete diagnosis of skin can
    Anita Mahadevan Jansen; Fiscal Year: 2009
    The incidence of skin cancer has been on the rise in recent years and as in most cancers, early diagnosis and thorough treatment (i.e., complete resection) are the keys to gain a favorable prognosis...
    SAM M MUKDADI; Fiscal Year: 2010
    ..pressing needs for the development of noninvasive and high-resolution biomedical imaging to achieve early diagnosis of periodontal disease...
    DAVID TAPPER; Fiscal Year: 1992
    ..It is commonly accepted that early diagnosis and treatment of breast cancer results in a more favorable prognosis; however, despite the increase use of ..
  68. HE3 MR Diffusion & Low Dose CT Quantitation of Emphysema
    David Gierada; Fiscal Year: 2005
    ..Accurate biomarkers of emphysema would allow for early diagnosis, intervention, and evaluation of new therapies...
  69. A finger-prick medical diagnostic for vitamin B12 malabsorption: An early interv
    STEPHEN DUEKER; Fiscal Year: 2006
    ..of hematological (pernicious anemia) and neurological disorders (dementia) which are usually reversible by early diagnosis and prompt treatment...
  70. Development of Population-Based Screening for DiGeorge Syndrome Type 1
    AOY MITCHELL; Fiscal Year: 2009
    ..b>Early diagnosis and appropriate medical intervention can prevent and effectively treat many of the co-morbidities associated ..
  71. PGA antigenemia for early diagnosis of anthrax
    Thomas Kozel; Fiscal Year: 2009
    ..The overall goal is production of a prototype immunoassay for PGA that can be used in a first responder clinical setting where anthrax will be initially encountered. ..
  72. FDG-PET Imaging in Complicated Diabetic Foot
    Abass Alavi; Fiscal Year: 2005
    ..In this population, osteomyelitis and deep infection of the foot are relatively common complications. Early diagnosis of these complications is crucial in the management of these patients, because prompt antibiotic treatment ..
  73. Assessment of Brain Iron and Neuronal Integrity Using Novel T1r and T2r MRI
    Shalom Michaeli; Fiscal Year: 2009
    ..Absence of a reliable biomarker severely limits early diagnosis, research on neuroprotective therapies and appreciation of disease pathogenesis...
    Frank Guenther; Fiscal Year: 2000
    ..These research areas are important for early diagnosis and proper treatment of speech disorders...
  75. A finger-prick medical diagnostic for vitamin B12 malabsorption - An early interv
    STEPHEN DUEKER; Fiscal Year: 2009
    ..to a wide spectrum of hematological and neurological disorders (dementia) which are usually reversible by early diagnosis and prompt treatment...
  76. Molecular Diagnosis of Dyslexia
    Seiyu Hosono; Fiscal Year: 2007
    ..We developed methods for accurately determining who is a carrier of RD alleles and that could be used for early diagnosis. At least two other RD genes have been identified as well: KIAA0319 and DYX1C1...
  77. Novel Ovarian Cancer Detection Agents from Phage Display
    SUSAN DEUTSCHER; Fiscal Year: 2009
    ..Improved early diagnosis and therapy will result from a more directed approach in which antigens specific to or overexpressed on ..
  78. Depth Maps From Stereo Images of the Optic Disc-Phase II
    GILBERTO ZAMORA; Fiscal Year: 2006
    ..Current research is aimed at developing methods of early diagnosis to detect the disease in the early stages, when treatment is most effective in minimizing irreversible vision ..
  79. Early Diagnosis of Oral Carcinoma Using Mutant PP32R1
    GERALD KOCHEVAR; Fiscal Year: 2006
    ..Identification of the intracellular protein ligands will provide a specific functional context for mutant PP32R1S. ..
  80. Imaging Regional Physiological and Structural Parameters of Airway Remodeling
    Kiarash Emami; Fiscal Year: 2009
    ..by applicant): Quantitative regional assessment of lung function and structure has the potential to enhance early diagnosis and management of lung disease, and to provide more effective assessment of therapy...
  81. New methods for the early diagnosis of invasive fungal infections
    Maurizio Del Poeta; Fiscal Year: 2009
    ..and genetic tools to study their development and progression, studies to provide better tools for an early diagnosis are urgently needed. Ultimately, these tools will significantly help in the management of invasive mycoses...
  82. A proteomic approach for early diagnosis of diabetes
    Julian Watts; Fiscal Year: 2005
    ..This facilitates the monitoring of potential candidate disease markers at the low ng/ml concentration exhibited by other known clinical markers such as the prostate cancer marker, PSA. ..