glomerular filtration rate

Summary

Summary: The volume of water filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time. It is considered to be equivalent to INULIN clearance.

Top Publications

  1. ncbi A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group
    A S Levey
    New England Medical Center, Boston, MA 02111, USA
    Ann Intern Med 130:461-70. 1999
  2. pmc A new equation to estimate glomerular filtration rate
    Andrew S Levey
    Tufts Medical Center, Boston, Massachusetts 02111, USA
    Ann Intern Med 150:604-12. 2009
  3. ncbi Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization
    Alan S Go
    Division of Research, Kaiser Permanente of Northern California, Oakland, CA 94612 2304, USA
    N Engl J Med 351:1296-305. 2004
  4. ncbi Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate
    Andrew S Levey
    Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Ann Intern Med 145:247-54. 2006
  5. ncbi Revised equations for estimated GFR from serum creatinine in Japan
    Seiichi Matsuo
    Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Am J Kidney Dis 53:982-92. 2009
  6. pmc Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis
    Kunihiro Matsushita
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 2024 E Monument, Suite 2 630, Baltimore, MD 21287, USA
    Lancet 375:2073-81. 2010
  7. ncbi Modified glomerular filtration rate estimating equation for Chinese patients with chronic kidney disease
    Ying Chun Ma
    Division of Nephrology and Institute of Nephrology, The First Hospital, Peking University, No 8 Xishiku Street, Xicheng District, Beijing 100034, PR China
    J Am Soc Nephrol 17:2937-44. 2006
  8. ncbi The definition, classification, and prognosis of chronic kidney disease: a KDIGO Controversies Conference report
    Andrew S Levey
    Division of Nephrology, Department of Medicine, Tufts Medical Center, Boston, Massachusetts, USA
    Kidney Int 80:17-28. 2011
  9. ncbi Definition and classification of chronic kidney disease: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO)
    Andrew S Levey
    Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Kidney Int 67:2089-100. 2005
  10. ncbi Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention
    Mark J Sarnak
    Circulation 108:2154-69. 2003

Detail Information

Publications338 found, 100 shown here

  1. ncbi A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group
    A S Levey
    New England Medical Center, Boston, MA 02111, USA
    Ann Intern Med 130:461-70. 1999
    Serum creatinine concentration is widely used as an index of renal function, but this concentration is affected by factors other than glomerular filtration rate (GFR).
  2. pmc A new equation to estimate glomerular filtration rate
    Andrew S Levey
    Tufts Medical Center, Boston, Massachusetts 02111, USA
    Ann Intern Med 150:604-12. 2009
    Equations to estimate glomerular filtration rate (GFR) are routinely used to assess kidney function. Current equations have limited precision and systematically underestimate measured GFR at higher values.
  3. ncbi Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization
    Alan S Go
    Division of Research, Kaiser Permanente of Northern California, Oakland, CA 94612 2304, USA
    N Engl J Med 351:1296-305. 2004
    ..End-stage renal disease substantially increases the risks of death, cardiovascular disease, and use of specialized health care, but the effects of less severe kidney dysfunction on these outcomes are less well defined...
  4. ncbi Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate
    Andrew S Levey
    Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Ann Intern Med 145:247-54. 2006
    b>Glomerular filtration rate (GFR) estimates facilitate detection of chronic kidney disease but require calibration of the serum creatinine assay to the laboratory that developed the equation...
  5. ncbi Revised equations for estimated GFR from serum creatinine in Japan
    Seiichi Matsuo
    Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Am J Kidney Dis 53:982-92. 2009
    Estimation of glomerular filtration rate (GFR) is limited by differences in creatinine generation among ethnicities...
  6. pmc Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis
    Kunihiro Matsushita
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 2024 E Monument, Suite 2 630, Baltimore, MD 21287, USA
    Lancet 375:2073-81. 2010
    Substantial controversy surrounds the use of estimated glomerular filtration rate (eGFR) and albuminuria to define chronic kidney disease and assign its stages...
  7. ncbi Modified glomerular filtration rate estimating equation for Chinese patients with chronic kidney disease
    Ying Chun Ma
    Division of Nephrology and Institute of Nephrology, The First Hospital, Peking University, No 8 Xishiku Street, Xicheng District, Beijing 100034, PR China
    J Am Soc Nephrol 17:2937-44. 2006
    ..The modified MDRD equations that were based on the Chinese patients with CKD offered significant advantages in different CKD stages and could be applied in clinical practice, at least in Chinese patients with CKD...
  8. ncbi The definition, classification, and prognosis of chronic kidney disease: a KDIGO Controversies Conference report
    Andrew S Levey
    Division of Nephrology, Department of Medicine, Tufts Medical Center, Boston, Massachusetts, USA
    Kidney Int 80:17-28. 2011
    ..and sponsored a Controversies Conference in October 2009 to examine the relationship of estimated glomerular filtration rate (GFR) and albuminuria to mortality and kidney outcomes...
  9. ncbi Definition and classification of chronic kidney disease: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO)
    Andrew S Levey
    Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Kidney Int 67:2089-100. 2005
    ..CKD is defined as kidney damage or glomerular filtration rate (GFR) <60 mL/min/1.73 m(2) for 3 months or more, irrespective of cause...
  10. ncbi Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention
    Mark J Sarnak
    Circulation 108:2154-69. 2003
  11. ncbi Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Third National Health and Nutrition Examination Survey
    Josef Coresh
    Department of Epidemiology, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD, USA
    Am J Kidney Dis 41:1-12. 2003
    ..assay provide a basis for estimating the prevalence and distribution of chronic kidney disease (CKD) in the United States using standardized criteria based on estimated glomerular filtration rate (GFR) and persistent albuminuria.
  12. ncbi Estimating glomerular filtration rate from serum creatinine and cystatin C
    Lesley A Inker
    Division of Nephrology, Tufts Medical Center, 800 Washington St, Box 391, Boston, MA 02111, USA
    N Engl J Med 367:20-9. 2012
    Estimates of glomerular filtration rate (GFR) that are based on serum creatinine are routinely used; however, they are imprecise, potentially leading to the overdiagnosis of chronic kidney disease...
  13. ncbi Assessing kidney function--measured and estimated glomerular filtration rate
    Lesley A Stevens
    Division of Nephrology, Tufts New England Medical Center, Boston, MA 02111, USA
    N Engl J Med 354:2473-83. 2006
  14. ncbi Estimating equations for glomerular filtration rate in the era of creatinine standardization: a systematic review
    Amy Earley
    Tufts Medical Center, Boston, MA 02111, USA
    Ann Intern Med 156:785-95, W-270, W-271, W-272, W-273, W-274, W-275, W-276, W-277, W-278. 2012
    Clinical laboratories are increasingly reporting estimated glomerular filtration rate (GFR) by using serum creatinine assays traceable to a standard reference material.
  15. ncbi Chronic kidney disease
    Andrew S Levey
    William B Schwartz Division of Nephrology, Tufts Medical Center, Boston, MA 02111, USA
    Lancet 379:165-80. 2012
    ..Disease and management are classified according to stages of disease severity, which are assessed from glomerular filtration rate (GFR) and albuminuria, and clinical diagnosis (cause and pathology)...
  16. pmc Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group
    Rinaldo Bellomo
    Department of Intensive Care and Medicine, Austin Health, Melbourne, Australia
    Crit Care 8:R204-12. 2004
    ..Accordingly, we sought to review the available evidence, make recommendations and delineate key questions for future studies...
  17. pmc Age and association of kidney measures with mortality and end-stage renal disease
    Stein I Hallan
    Division of Nephrology, Department of Medicine, St Olav University Hospital, and Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    JAMA 308:2349-60. 2012
    Chronic kidney disease (CKD) is prevalent in older individuals, but the risk implications of low estimated glomerular filtration rate (eGFR) and high albuminuria across the full age range are controversial.
  18. pmc Comparison of risk prediction using the CKD-EPI equation and the MDRD study equation for estimated glomerular filtration rate
    Kunihiro Matsushita
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
    JAMA 307:1941-51. 2012
    The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation more accurately estimates glomerular filtration rate (GFR) than the Modification of Diet in Renal Disease (MDRD) Study equation using the same variables, especially ..
  19. pmc New loci associated with kidney function and chronic kidney disease
    Anna Kottgen
    Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA
    Nat Genet 42:376-84. 2010
    ..These results further our understanding of the biologic mechanisms of kidney function by identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute transport and metabolic functions of the kidney...
  20. ncbi Serum cystatin C is superior to serum creatinine as a marker of kidney function: a meta-analysis
    Vikas R Dharnidharka
    Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL 32610 0296, USA
    Am J Kidney Dis 40:221-6. 2002
    Serum cystatin C (Cys C) has been proposed as a simple, accurate, and rapid endogenous marker of glomerular filtration rate (GFR) in research and clinical practice...
  21. pmc Lower estimated GFR and higher albuminuria are associated with adverse kidney outcomes. A collaborative meta-analysis of general and high-risk population cohorts
    Ron T Gansevoort
    Department of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Kidney Int 80:93-104. 2011
    Both a low estimated glomerular filtration rate (eGFR) and albuminuria are known risk factors for end-stage renal disease (ESRD)...
  22. pmc New equations to estimate GFR in children with CKD
    George J Schwartz
    Department of Pediatrics, University of Rochester School of Medicine, Rochester, NY 14642, USA
    J Am Soc Nephrol 20:629-37. 2009
    ..413*(height/serum creatinine), provides a good approximation to the estimated GFR formula. Additional studies of children with higher GFR are needed to validate these formulas for use in screening all children for CKD...
  23. ncbi The Oxford classification of IgA nephropathy: rationale, clinicopathological correlations, and classification
    Daniel C Cattran
    University Health Network, Toronto General Research Institute, Toronto, Ontario, Canada
    Kidney Int 76:534-45. 2009
    ..The value of crescents was not addressed due to their low prevalence in the enrolled cohort...
  24. ncbi Relation between renal dysfunction and cardiovascular outcomes after myocardial infarction
    Nagesh S Anavekar
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 351:1285-95. 2004
    ..Renal failure is associated with one of the highest risks, but the influence of milder degrees of renal impairment is less well defined...
  25. pmc Albuminuria and kidney function independently predict cardiovascular and renal outcomes in diabetes
    Toshiharu Ninomiya
    George Institute for International Health, University of Sydney, Sydney, NSW, Australia
    J Am Soc Nephrol 20:1813-21. 2009
    ..In conclusion, high albuminuria and low eGFR are independent risk factors for cardiovascular and renal events among patients with type 2 diabetes...
  26. ncbi Two novel equations to estimate kidney function in persons aged 70 years or older
    Elke S Schaeffner
    Charite University Medicine, Campi Virchow, Mitte, Germany
    Ann Intern Med 157:471-81. 2012
    In older adults, current equations to estimate glomerular filtration rate (GFR) are not validated and may misclassify elderly persons in terms of their stage of chronic kidney disease.
  27. ncbi Relation between kidney function, proteinuria, and adverse outcomes
    Brenda R Hemmelgarn
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    JAMA 303:423-9. 2010
    The current staging system for chronic kidney disease is based primarily on estimated glomerular filtration rate (eGFR) with lower eGFR associated with higher risk of adverse outcomes...
  28. ncbi Chronic kidney disease: effects on the cardiovascular system
    Ernesto L Schiffrin
    Department of Medicine, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Circulation 116:85-97. 2007
    ..Prevention and treatment of cardiovascular disease are major considerations in the management of individuals with chronic kidney disease...
  29. ncbi Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic kidney disease: results of the study to evaluate early kidney disease
    A Levin
    Department of Nephrology, University of British Columbia, Vancouver, BC, Canada
    Kidney Int 71:31-8. 2007
    ..1 years old; 48% had diabetes mellitus (DM). Low 1,25 OH2 D3 was evident at all estimated glomerular filtration rate (eGFR) levels: 13% in those with eGFR >80 ml/min, >60% in those with eGFR <30 ml/min...
  30. pmc Comparative performance of the CKD Epidemiology Collaboration (CKD-EPI) and the Modification of Diet in Renal Disease (MDRD) Study equations for estimating GFR levels above 60 mL/min/1.73 m2
    Lesley A Stevens
    Tufts Medical Center, Boston, MA 02111, USA
    Am J Kidney Dis 56:486-95. 2010
    The Modification of Diet in Renal Disease (MDRD) Study equation underestimates measured glomerular filtration rate (GFR) at levels>60 mL/min/1...
  31. ncbi Expressing the Modification of Diet in Renal Disease Study equation for estimating glomerular filtration rate with standardized serum creatinine values
    Andrew S Levey
    Division of Nephrology, Tufts New England Medical Center, Boston, MA 02111, USA
    Clin Chem 53:766-72. 2007
    We sought to reexpress the 4-variable Modification of Diet in Renal Disease (MDRD) Study equation for estimation of glomerular filtration rate (GFR) using serum creatinine (S(cr)) standardized to reference methods.
  32. ncbi Creatinine fluctuation has a greater effect than the formula to estimate glomerular filtration rate on the prevalence of chronic kidney disease
    Simon de Lusignan
    Division of Community Health Sciences, St George s, University of London, London, UK
    Nephron Clin Pract 117:c213-24. 2011
    Cases of chronic kidney disease (CKD) are defined by the estimated glomerular filtration rate (eGFR), calculated using the Modified Diet in Renal Disease (MDRD) or, more recently, the CKD Epidemiology Collaboration (CKD-EPI) formula...
  33. pmc Estimating GFR using serum cystatin C alone and in combination with serum creatinine: a pooled analysis of 3,418 individuals with CKD
    Lesley A Stevens
    Division of Nephrology, Tufts New England Medical Center, 750 Washington St, Box 391, Boston, MA 02111, USA
    Am J Kidney Dis 51:395-406. 2008
    Serum cystatin C was proposed as a potential replacement for serum creatinine in glomerular filtration rate (GFR) estimation...
  34. ncbi Predictors of new-onset kidney disease in a community-based population
    Caroline S Fox
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Mass 01702, USA
    JAMA 291:844-50. 2004
    ..Kidney disease is associated with an increased risk for the development of cardiovascular disease and end-stage renal disease; however, risk factors for kidney disease have not been well studied...
  35. ncbi Lower estimated glomerular filtration rate and higher albuminuria are associated with all-cause and cardiovascular mortality. A collaborative meta-analysis of high-risk population cohorts
    Marije van der Velde
    Department of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Kidney Int 79:1341-52. 2011
    ..recommended in people at high risk, but data on the independent and combined associations of estimated glomerular filtration rate (eGFR) and albuminuria with all-cause and cardiovascular mortality are limited...
  36. pmc Effect of allopurinol in chronic kidney disease progression and cardiovascular risk
    Marian Goicoechea
    Servicio de Nefrologia, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    Clin J Am Soc Nephrol 5:1388-93. 2010
    ..Hyperuricemia is associated with hypertension, inflammation, renal disease progression, and cardiovascular disease. However, no data are available regarding the effect of allopurinol in patients with chronic kidney disease...
  37. pmc Ethnic coefficients for glomerular filtration rate estimation by the Modification of Diet in Renal Disease study equations in the Korean population
    Chung Sik Lee
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    J Korean Med Sci 25:1616-25. 2010
    Race and ethnicity are influential in estimating glomerular filtration rate (GFR)...
  38. ncbi Prevalence of chronic kidney disease in the Japanese general population
    Enyu Imai
    Department of Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Clin Exp Nephrol 13:621-30. 2009
    ..We re-estimated the prevalence of CKD by measuring proteinuria using a dipstick test and by calculating the GFR using a new equation that estimates GFR based on data from the Japanese annual health check program in 2005...
  39. ncbi All-cause mortality attributable to chronic kidney disease: a prospective cohort study based on 462 293 adults in Taiwan
    Chi Pang Wen
    Center for Health Policy Research and Development, National Health Research Institutes, Zhunan, Taiwan
    Lancet 371:2173-82. 2008
    ..We assessed prevalence and mortality risks for all stages of chronic kidney disease and quantified its attributable mortality in Taiwan...
  40. ncbi Olmesartan for the delay or prevention of microalbuminuria in type 2 diabetes
    Hermann Haller
    Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany
    N Engl J Med 364:907-17. 2011
    ..We investigated whether treatment with an angiotensin-receptor blocker (ARB) would delay or prevent the occurrence of microalbuminuria in patients with type 2 diabetes and normoalbuminuria...
  41. pmc Timing of onset of CKD-related metabolic complications
    Olivier Moranne
    INSERM Unit 780, 16, avenue Paul Vaillant Couturier, 94807 Villejuif Cedex, France
    J Am Soc Nephrol 20:164-71. 2009
    ..In summary, this study describes the onset of CKD-related complications at different levels of GFR; anemia and hyperparathyroidism occur earlier than acidosis, hyperkalemia, and hyperphosphatemia...
  42. ncbi Chronic kidney disease management in the United Kingdom: NEOERICA project results
    P E Stevens
    Department of Renal Medicine, East Kent Hospitals NHS Trust, Kent and Canterbury Hospital, Ethelbert Road, Canterbury, Kent, UK
    Kidney Int 72:92-9. 2007
    ..Estimated glomerular filtration rate was calculated from the four-variable Modification of Diet in Renal Disease equation using calibrated ..
  43. ncbi Recommendations for improving serum creatinine measurement: a report from the Laboratory Working Group of the National Kidney Disease Education Program
    Gary L Myers
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Clin Chem 52:5-18. 2006
    Reliable serum creatinine measurements in glomerular filtration rate (GFR) estimation are critical to ongoing global public health efforts to increase the diagnosis and treatment of chronic kidney disease (CKD)...
  44. ncbi A randomized, controlled trial of early versus late initiation of dialysis
    Bruce A Cooper
    Department of Renal Medicine, Royal North Shore Hospital, Sydney Medical School, Sydney, Australia
    N Engl J Med 363:609-19. 2010
    ..In this study, conducted at 32 centers in Australia and New Zealand, we examined whether the timing of the initiation of maintenance dialysis influenced survival among patients with chronic kidney disease...
  45. ncbi Chronic kidney disease as cause of cardiovascular morbidity and mortality
    R Vanholder
    Nephrology Section, 0K12, University Hospital, De Pintelaan 185, B 9000 Gent, Belgium
    Nephrol Dial Transplant 20:1048-56. 2005
    ..very early during the evolution of renal failure: an accelerated cardiovascular risk appears at varying glomerular filtration rate (GFR) cut-off values, which were >/=60 ml/min in at least 20 studies...
  46. pmc Renal and retinal effects of enalapril and losartan in type 1 diabetes
    Michael Mauer
    Department of Pediatrics, University of Minnesota, Minneapolis 55455, USA
    N Engl J Med 361:40-51. 2009
    ..Nephropathy and retinopathy remain important complications of type 1 diabetes. It is unclear whether their progression is slowed by early administration of drugs that block the renin-angiotensin system...
  47. pmc Diverging association of reduced glomerular filtration rate and albuminuria with coronary and noncoronary events in patients with type 2 diabetes: the renal insufficiency and cardiovascular events (RIACE) Italian multicenter study
    Anna Solini
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Diabetes Care 35:143-9. 2012
    Although a reduced estimated glomerular filtration rate (eGFR) was shown to be a powerful independent predictor of cardiovascular disease (CVD), other studies suggested that it confers a much lower risk than albuminuria alone, whereas the ..
  48. pmc Multiple loci associated with indices of renal function and chronic kidney disease
    Anna Kottgen
    Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA
    Nat Genet 41:712-7. 2009
    ..We conducted genome-wide association studies (GWAS) to identify susceptibility loci for glomerular filtration rate, estimated by serum creatinine (eGFRcrea) and cystatin C (eGFRcys), and CKD (eGFRcrea < 60 ml/min/1...
  49. pmc Development and progression of renal insufficiency with and without albuminuria in adults with type 1 diabetes in the diabetes control and complications trial and the epidemiology of diabetes interventions and complications study
    Mark E Molitch
    Northwestern University, Chicago, Illinois, USA
    Diabetes Care 33:1536-43. 2010
    This multicenter study examined the impact of albumin excretion rate (AER) on the course of estimated glomerular filtration rate (eGFR) and the incidence of sustained eGFR <60 ml/min/1...
  50. ncbi Renal impairment and outcomes in heart failure: systematic review and meta-analysis
    Grace L Smith
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Am Coll Cardiol 47:1987-96. 2006
    ..We estimated the prevalence of renal impairment in heart failure (HF) patients and the magnitude of associated mortality risk using a systematic review of published studies...
  51. ncbi Cystatin C and the risk of death and cardiovascular events among elderly persons
    Michael G Shlipak
    General Internal Medicine Section, Veterans Affairs Medical Center, University of California, San Francisco, USA
    N Engl J Med 352:2049-60. 2005
    ..We compared creatinine and cystatin C levels as predictors of mortality from cardiovascular causes and from all causes in the Cardiovascular Health Study, a cohort study of elderly persons living in the community...
  52. ncbi Vitamin D levels and patient outcome in chronic kidney disease
    Pietro Ravani
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    Kidney Int 75:88-95. 2009
    ..All patients were clinically stable and had an estimated glomerular filtration rate (eGFR) at stage 2 or less and were without an imminent need for dialysis...
  53. pmc Genetic loci influencing kidney function and chronic kidney disease
    John C Chambers
    Department of Epidemiology and Biostatistics, School of Public Health, Imperial College of London, London, UK
    Nat Genet 42:373-5. 2010
    ..0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease...
  54. pmc Imprecision of urinary iothalamate clearance as a gold-standard measure of GFR decreases the diagnostic accuracy of kidney function estimating equations
    Yuen Ting Diana Kwong
    Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, MD
    Am J Kidney Dis 56:39-49. 2010
    Evaluating the accuracy of estimated glomerular filtration rate (eGFR) derived from serum creatinine (SCr) and serum cystatin C (SCysC) equations requires gold-standard measures of GFR...
  55. pmc Novel markers of kidney function as predictors of ESRD, cardiovascular disease, and mortality in the general population
    Brad C Astor
    Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, MD, USA
    Am J Kidney Dis 59:653-62. 2012
    ..It is unknown whether this advantage extends to other outcomes, such as kidney failure, or whether other novel renal filtration markers share this advantage in predicting outcomes...
  56. ncbi Uric acid levels predict future development of chronic kidney disease
    Hiroo Sonoda
    Department of Cardio Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Am J Nephrol 33:352-7. 2011
    ..Increased uric acid levels are associated with kidney dysfunction. We tested the hypothesis that uric acid level predicts future development of chronic kidney disease (CKD) in the general population...
  57. ncbi Screening for, monitoring, and treatment of chronic kidney disease stages 1 to 3: a systematic review for the U.S. Preventive Services Task Force and for an American College of Physicians Clinical Practice Guideline
    Howard A Fink
    Geriatric Research, Education, and Clinical Center, Minneapolis, Minnesota, USA
    Ann Intern Med 156:570-81. 2012
    ..Screening and monitoring for chronic kidney disease (CKD) could lead to earlier interventions that improve clinical outcomes...
  58. ncbi Relationship of uric acid with progression of kidney disease
    Michel Chonchol
    Division of Renal Diseases and Hypertension, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Kidney Dis 50:239-47. 2007
    ..Uric acid levels are increased in patients with kidney dysfunction. We tested the hypothesis that uric acid may be associated with kidney disease progression...
  59. pmc Normalization of urinary biomarkers to creatinine during changes in glomerular filtration rate
    Sushrut S Waikar
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Kidney Int 78:486-94. 2010
    ..reflecting tubular injury can be influenced by dynamic changes in the UCr excretion rate when the glomerular filtration rate changes...
  60. pmc Estimated glomerular filtration rate is a poor predictor of concentration for a broad range of uremic toxins
    Sunny Eloot
    Nephrology Section, Department of Internal Medicine, Ghent University Hospital, Ghent, Belgium
    Clin J Am Soc Nephrol 6:1266-73. 2011
    ..The purpose of this study was to investigate whether eGFR values are representative for uremic toxin concentrations in patients with different degrees of CKD...
  61. pmc Performance of creatinine and cystatin C GFR estimating equations in an HIV-positive population on antiretrovirals
    Lesley A Inker
    Tufts Medical Center, Boston, MA, USA
    J Acquir Immune Defic Syndr 61:302-9. 2012
    ..To evaluate the performance of Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine, cystatin C, and creatinine-cystatin C estimating equations in HIV-positive patients...
  62. ncbi International comparison of the relationship of chronic kidney disease prevalence and ESRD risk
    Stein I Hallan
    Department of Medicine, Division of Nephrology, St Olav University Hospital, N 7006 Trondheim, Norway
    J Am Soc Nephrol 17:2275-84. 2006
    ..In conclusion, CKD prevalence in Norway was similar to that in the United States, suggesting that lower progression to ESRD rather than a smaller pool of individuals at risk accounts for the lower incidence of ESRD in Norway...
  63. ncbi Association of hyperuricemia with renal outcomes, cardiovascular disease, and mortality
    Wan Chun Liu
    Department of Internal Medicine, Kaohsiung Municipal Hsiao Kang Hospital, Taiwan
    Clin J Am Soc Nephrol 7:541-8. 2012
    ..Hyperuricemia is an independent risk factor for mortality, cardiovascular disease, and renal disease in general population. However, the relationship between hyperuricemia with clinical outcomes in CKD remains controversial...
  64. ncbi Accuracy of the MDRD (Modification of Diet in Renal Disease) study and CKD-EPI (CKD Epidemiology Collaboration) equations for estimation of GFR in the elderly
    Hannah S Kilbride
    The Kent Kidney Care Centre, East Kent Hospitals University NHS Foundation Trust, Canterbury, Kent, United Kingdom
    Am J Kidney Dis 61:57-66. 2013
    b>Glomerular filtration rate (GFR) is a measure of kidney function, commonly estimated using equations that adjust serum creatinine concentration for age, race, and sex...
  65. pmc Lower estimated glomerular filtration rate and higher albuminuria are associated with mortality and end-stage renal disease. A collaborative meta-analysis of kidney disease population cohorts
    Brad C Astor
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Kidney Int 79:1331-40. 2011
    We studied here the independent associations of estimated glomerular filtration rate (eGFR) and albuminuria with mortality and end-stage renal disease (ESRD) in individuals with chronic kidney disease (CKD)...
  66. ncbi Estimated glomerular filtration rate and albuminuria are independent predictors of cardiovascular events and death in type 2 diabetes mellitus: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study
    P L Drury
    Auckland Diabetes Centre, New Zealand
    Diabetologia 54:32-43. 2011
    ..We investigated effects of renal function and albuminuria on cardiovascular outcomes in 9,795 low-risk patients with diabetes in the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study...
  67. ncbi Very low levels of microalbuminuria are associated with increased risk of coronary heart disease and death independently of renal function, hypertension, and diabetes
    Klaus Klausen
    Copenhagen City Heart Study, Epidemiological Research Unit, Bispebjerg University Hospital, Copenhagen, Denmark
    Circulation 110:32-5. 2004
    ..Microalbuminuria has been suggested as an atherosclerotic risk factor. However, the lower cutoff level of urinary albumin excretion is unknown. It is also unknown whether impaired renal function confounds the association...
  68. ncbi Using serum creatinine to estimate glomerular filtration rate: accuracy in good health and in chronic kidney disease
    Andrew D Rule
    Mayo Clinic, Rochester, Minnesota 55905, USA
    Ann Intern Med 141:929-37. 2004
    ..advocated the use of the abbreviated Modification of Diet in Renal Disease (MDRD) equation to estimate glomerular filtration rate (GFR) from serum creatinine measurements in clinical laboratories...
  69. ncbi Renal insufficiency and subsequent death resulting from cardiovascular disease in the United States
    Paul Muntner
    Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana 70112, USA
    J Am Soc Nephrol 13:745-53. 2002
    ..This study indicates that, in a representative sample of the United States general population, renal insufficiency is independently associated with increased cardiovascular disease-related and all-cause mortality rates...
  70. ncbi Simple cystatin C-based prediction equations for glomerular filtration rate compared with the modification of diet in renal disease prediction equation for adults and the Schwartz and the Counahan-Barratt prediction equations for children
    Anders Grubb
    Department of Clinical Chemistry, Competence Centre for Clinical Research, Department of Nephrology, University Hospital, Lund, Sweden
    Clin Chem 51:1420-31. 2005
    Serum creatinine is the most commonly used marker for estimation of glomerular filtration rate (GFR)...
  71. ncbi Comparison of the prevalence and mortality risk of CKD in Australia using the CKD Epidemiology Collaboration (CKD-EPI) and Modification of Diet in Renal Disease (MDRD) Study GFR estimating equations: the AusDiab (Australian Diabetes, Obesity and Lifestyle
    Sarah L White
    The George Institute for International Health, Sydney, NSW, Australia
    Am J Kidney Dis 55:660-70. 2010
    ..The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) is more accurate than the Modification of Diet in Renal Disease (MDRD) Study equation. We applied both equations in a cohort representative of the Australian adult population...
  72. ncbi Estimated glomerular filtration rate, chronic kidney disease and antiretroviral drug use in HIV-positive patients
    Amanda Mocroft
    HIV Epidemiology and Biostatistics Group, Research Department of Infection and Population Health, Division of Population Health, University College London Medical School, Royal Free Campus, London, UK
    AIDS 24:1667-78. 2010
    ..Chronic kidney disease (CKD) in HIV-positive persons might be caused by both HIV and traditional or non-HIV-related factors. Our objective was to investigate long-term exposure to specific antiretroviral drugs and CKD...
  73. pmc Risk implications of the new CKD Epidemiology Collaboration (CKD-EPI) equation compared with the MDRD Study equation for estimated GFR: the Atherosclerosis Risk in Communities (ARIC) Study
    Kunihiro Matsushita
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Welch Center for Prevention, Epidemiology, and Clinical Research, Baltimore, MD 21287, USA
    Am J Kidney Dis 55:648-59. 2010
    ..Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) recently published an equation for estimated glomerular filtration rate (eGFR) using the same variables (serum creatinine level, age, sex, and race) as the Modification of Diet ..
  74. ncbi Performance of the modification of diet in renal disease and Cockcroft-Gault equations in the estimation of GFR in health and in chronic kidney disease
    Emilio D Poggio
    Department of Nephrology and Hypertension, The Cleveland Clinic Foundation, A51, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Am Soc Nephrol 16:459-66. 2005
    ..This study also emphasizes the complexity of laboratory calibration of serum creatinine measurements, a determining factor when estimating GFR in both healthy individuals and CKD patients with preserved GFR...
  75. ncbi Impact of the clinical conditions at dialysis initiation on mortality in incident haemodialysis patients: a national cohort study in Taiwan
    Shang Jyh Hwang
    Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    Nephrol Dial Transplant 25:2616-24. 2010
    b>Glomerular filtration rate (GFR) and co-morbidity at dialysis initiation in relation to mortality in end-stage renal disease is still controversial...
  76. pmc Prevalence of chronic kidney disease in persons with undiagnosed or prehypertension in the United States
    Deidra C Crews
    Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
    Hypertension 55:1102-9. 2010
    ..Chronic kidney disease was defined as estimated glomerular filtration rate <60 mL/min per 1.73 m(2) or urinary albumin:creatinine ratio >30 mg/g...
  77. ncbi Measurement and estimation of GFR in children and adolescents
    George J Schwartz
    Department of Pediatrics, Pediatric Nephrology, Box 777, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Clin J Am Soc Nephrol 4:1832-43. 2009
    ..However, at this time, there is no dependable substitute for an accurately determined GFR, and iohexol plasma disappearance offers the best combination of safety, accuracy, and reproducible precision...
  78. ncbi Cystatin C as a marker of GFR--history, indications, and future research
    Guido Filler
    Department of Pediatrics, Children s Hospital of Eastern Ontario, University of Ottawa, Ottawa, Canada
    Clin Biochem 38:1-8. 2005
    To summarize recent knowledge on the small molecular weight protein cystatin C (cys-C) and its use as a marker of the glomerular filtration rate (GFR).
  79. ncbi Urinary neutrophil gelatinase associated lipocalin (NGAL), a marker of tubular damage, is increased in patients with chronic heart failure
    Kevin Damman
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Eur J Heart Fail 10:997-1000. 2008
    Renal impairment, as measured by reduced glomerular filtration rate (GFR) and increased urinary albumin excretion (UAE), is prevalent in patients with chronic heart failure (CHF) and is associated with reduced survival...
  80. ncbi Elevated resistin levels in chronic kidney disease are associated with decreased glomerular filtration rate and inflammation, but not with insulin resistance
    J Axelsson
    Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital at Huddinge, Stockholm, Sweden
    Kidney Int 69:596-604. 2006
    ..b>Glomerular filtration rate (GFR) was estimated by the mean of urea and creatinine clearance (24-h urine samples) (n=204) or by ..
  81. ncbi Randomized comparison of renal effects, efficacy, and safety with once-daily abacavir/lamivudine versus tenofovir/emtricitabine, administered with efavirenz, in antiretroviral-naive, HIV-1-infected adults: 48-week results from the ASSERT study
    Frank A Post
    King s College London, London, United Kingdom
    J Acquir Immune Defic Syndr 55:49-57. 2010
    ..Abacavir/lamivudine and tenofovir/emtricitabine fixed-dose combinations are commonly used first-line antiretroviral therapies, yet few studies have comprehensively compared their safety profiles...
  82. pmc Rapid decline of kidney function increases cardiovascular risk in the elderly
    Michael G Shlipak
    General Internal Medicine Section, San Francisco VA Medical Center and Departments of Medicine, Epidemiology, and Biostatistics, University of California San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
    J Am Soc Nephrol 20:2625-30. 2009
    ..97 to 1.45). The association of rapid decline with each outcome did not differ by the presence or absence of CKD. In conclusion, declining kidney function associates with higher risk for HF, MI, and PAD among patients with or without CKD...
  83. pmc Evaluation of the Chronic Kidney Disease Epidemiology Collaboration equation for estimating the glomerular filtration rate in multiple ethnicities
    Lesley A Stevens
    Division of Nephrology, Tufts Medical Center, Boston, Massachusetts 02111, USA
    Kidney Int 79:555-62. 2011
    ..the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) provides more accurate estimates of the glomerular filtration rate (eGFR) than that from the modification of diet in renal disease (MDRD) Study, although both include a ..
  84. ncbi Greater tenofovir-associated renal function decline with protease inhibitor-based versus nonnucleoside reverse-transcriptase inhibitor-based therapy
    Miguel Goicoechea
    Antiviral Research Center, University of California, San Diego, 150 W Washington St, Ste 100, San Diego, CA 92103, USA
    J Infect Dis 197:102-8. 2008
    ....
  85. ncbi Effects of fenofibrate on renal function in patients with type 2 diabetes mellitus: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) Study
    T M E Davis
    School of Medicine and Pharmacology, Fremantle Hospital, University of Western Australia, Fremantle, WA, Australia
    Diabetologia 54:280-90. 2011
    ..We assessed fenofibrate's renal effects overall and in a FIELD washout sub-study...
  86. ncbi Serum cystatin C as a new marker for noninvasive estimation of glomerular filtration rate and as a marker for early renal impairment
    E Coll
    Services of Nephrology, Biochemistry, Statistics, and Nuclear Medicine, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, University of Barcelona, Spain
    Am J Kidney Dis 36:29-34. 2000
    ..is independent of age, sex, and muscle mass, it has been postulated to be an improved marker of glomerular filtration rate (GFR) compared with serum creatinine level...
  87. ncbi Effect of blood pressure lowering and antihypertensive drug class on progression of hypertensive kidney disease: results from the AASK trial
    Jackson T Wright
    Case Western Reserve University, Department of Medicine, University Hospitals of Cleveland and the Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH 44106 5014, USA
    JAMA 288:2421-31. 2002
    ..Hypertension is a leading cause of end-stage renal disease (ESRD) in the United States, with no known treatment to prevent progressive declines leading to ESRD...
  88. pmc Elevated uric acid increases the risk for kidney disease
    Rudolf P Obermayr
    3rd Medical Department, Donauspital, Sozialmedizinisches Zentrum Ost der Stadt Wien, Langobardenstrasse 122, A 1220 Vienna, Austria EU
    J Am Soc Nephrol 19:2407-13. 2008
    ..In conclusion, elevated levels of uric acid independently increase the risk for new-onset kidney disease...
  89. pmc The estimated GFR, but not the stage of diabetic nephropathy graded by the urinary albumin excretion, is associated with the carotid intima-media thickness in patients with type 2 diabetes mellitus: a cross-sectional study
    Hiroyuki Ito
    Department of Diabetes, Metabolism and Kidney Disease, Edogawa Hospital, Tokyo, Japan
    Cardiovasc Diabetol 9:18. 2010
    ..IMT) of the carotid artery and the stage of chronic kidney disease (CKD) based on the estimated glomerular filtration rate (eGFR) and diabetic nephropathy graded by the urinary albumin excretion (UAE) in the patients with type ..
  90. pmc Uric acid and long-term outcomes in CKD
    Magdalena Madero
    Department of Medicine, Division of Nephrology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico
    Am J Kidney Dis 53:796-803. 2009
    ..Hyperuricemia is prevalent in patients with chronic kidney disease (CKD); however, data are limited about the relationship of uric acid levels with long-term outcomes in this patient population...
  91. ncbi A comparison between cystatin C, plasma creatinine and the Cockcroft and Gault formula for the estimation of glomerular filtration rate
    Frans J Hoek
    Academic Medical Center, Department of Clinical Chemistry, Room F1 219, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    Nephrol Dial Transplant 18:2024-31. 2003
    In clinical practice, the glomerular filtration rate (GFR) is often estimated from plasma creatinine. Several studies have shown cystatin C (cys C) to be a better parameter for the diagnosis of impaired renal function...
  92. ncbi Worsening renal function and prognosis in heart failure: systematic review and meta-analysis
    Kevin Damman
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Card Fail 13:599-608. 2007
    ..The present study was designed to establish the proportion of patients with HF that exhibits (WRF) and the associated risk for mortality and hospitalization by conducting a systematic review and meta-analysis...
  93. ncbi Does the ID-MS traceable MDRD equation work and is it suitable for use with compensated Jaffe and enzymatic creatinine assays?
    Susan Vickery
    Department of Clinical Biochemistry, East Kent Hospitals NHS Trust, Kent and Canterbury Hospital, Canterbury, Kent CT1 3NG, UK
    Nephrol Dial Transplant 21:2439-45. 2006
    ..recommendations suggest that measurement of serum creatinine should be supplemented with an estimate of glomerular filtration rate (GFR) using the Modification of Diet in Renal Disease (MDRD) study equation...
  94. ncbi Calibration of serum creatinine in the National Health and Nutrition Examination Surveys (NHANES) 1988-1994, 1999-2004
    Elizabeth Selvin
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21287, USA
    Am J Kidney Dis 50:918-26. 2007
    ....
  95. ncbi Decreased cardiac output, venous congestion and the association with renal impairment in patients with cardiac dysfunction
    Kevin Damman
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Eur J Heart Fail 9:872-8. 2007
    ..Renal failure in heart failure is related to decreased cardiac output. However, little is known about its association with venous congestion...
  96. ncbi Estimating glomerular filtration rate in HIV-infected adults in Africa: comparison of Cockcroft-Gault and Modification of Diet in Renal Disease formulae
    Wolfgang Stöhr
    MRC Clinical Trials Unit, London, UK
    Antivir Ther 13:761-70. 2008
    Cockcroft-Gault (CG) and Modification of Diet in Renal Disease (MDRD) formulae are recommended for glomerular filtration rate (GFR) estimation, but neither has been validated or directly compared longitudinally in HIV-infected patients or ..
  97. pmc Defining incident chronic kidney disease in the research setting: The ARIC Study
    Lori D Bash
    Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21201, USA
    Am J Epidemiol 170:414-24. 2009
    ..The estimated glomerular filtration rate (eGFR) was based on serum creatinine at baseline and the 3- and 9-year follow-up visits...
  98. ncbi Kidney function is inversely associated with coronary artery calcification in men and women free of cardiovascular disease: the Framingham Heart Study
    Caroline S Fox
    NHLBI s Framingham Heart Study, Framingham, Massachusetts, USA
    Kidney Int 66:2017-21. 2004
    ..Because the risk of coronary heart disease is increased even at moderate declines in kidney function, we sought to test whether high CAC scores are seen among those with mild reductions in kidney function...
  99. pmc Association of mild to moderate kidney dysfunction and coronary calcification
    Joachim H Ix
    Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, and San Diego VA Healthcare System, 3350 La Jolla Village Drive, Mail Code 111 H, San Diego, CA 92161, USA
    J Am Soc Nephrol 19:579-85. 2008
    ..These results suggest that a higher burden of CAC is unlikely to explain the association between mild to moderate kidney dysfunction and cardiovascular mortality...
  100. ncbi Reduced kidney function and anemia as risk factors for mortality in patients with left ventricular dysfunction
    A Al-Ahmad
    Division of Cardiology, Department of Medicine, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Am Coll Cardiol 38:955-62. 2001
    ..METHODS: We retrospectively examined the Studies Of LV Dysfunction (SOLVD) database. Glomerular filtration rate (GFR) was predicted using a recently validated formula...
  101. ncbi Evaluation of the modification of diet in renal disease study equation in a large diverse population
    Lesley A Stevens
    Division of Nephrology, Tufts New England Medical Center, 750 Washington Street, Box 391, Boston, MA 02111, USA
    J Am Soc Nephrol 18:2749-57. 2007
    b>Glomerular filtration rate (GFR) estimates facilitate detection of chronic kidney disease. Performance of the Modification of Diet in Renal Disease (MDRD) Study equation varies substantially among populations...

Research Grants73

  1. Angiotensin Adrenergic Interactions in the Kidney
    Roland C Blantz; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Project Summary/Abstract In the normal kidney glomerular filtration rate (GFR) is accompanied by parallel changes in Na reabsorption (TNa)...
  2. New insights in mechanisms of renal injury
    Balakuntalam S Kasinath; Fiscal Year: 2013
    ..b>Glomerular filtration rate (GFR) and albuminuria will be measured...
  3. A multicenter clinical trial of allopurinol to prevent GFR loss in T1D
    S MICHAEL MAUER; Fiscal Year: 2012
    ..To study whether uric acid lowering can reduce glomerular filtration rate (GFR) loss in T1D, we have established the PERL (Preventing Early Renal Function Loss in Diabetes) ..
  4. Oxidative Stress in Chronic Kidney Disease
    Talat Alp Ikizler; Fiscal Year: 2012
    ABSTRACT Chronic kidney disease (CKD), defined as a persistently reduced glomerular filtration rate (GFR), is an important public health problem affecting more than 26 million Americans...
  5. Markers of Renal Damage in Renovascular Hypertension
    Juan C Romero; Fiscal Year: 2011
    ..uncertainties are due to the lack of important information about the changes in intrarenal hemodynamics, glomerular filtration rate and proximal and distal tubular function in the stenotic kidney (ST-KD) as well as in the contralateral ..
  6. Effect of Ultrafiltration on Clinical Outcomes and Health-related Quality of Life
    KELLY VICTORIA LIANG; Fiscal Year: 2013
    ..prospective randomized study of hospitalized HF patients with underlying renal dysfunction (estimated glomerular filtration rate (GFR) 15-59 mL/min) treated with either protocolized treatment with early UF after failing medical ..
  7. Central Biochemistry Laboratory of the CKiD Consortium
    George J Schwartz; Fiscal Year: 2013
    ..sites with protocols, kits, reagents, supplies, and transportation required for performing iohexol-based glomerular filtration rate (GFR) studies and collecting blood and urine for analysis at URMC and other laboratories...
  8. Design of a Multicenter Clinical Trial of Allopurinol to Prevent GFR Loss in T1D
    S MICHAEL MAUER; Fiscal Year: 2011
    ..To study whether uric acid lowering can reduce glomerular filtration rate (GFR) loss in T1D, we have established a consortium that includes investigators from the Joslin Diabetes ..
  9. Contribution of Gstm1 to the severity of hypertension and chronic kidney disease
    Thu H Le; Fiscal Year: 2013
    ..We found that the hazard ratios (HR) for the time to glomerular filtration rate (GFR) event, dialysis or death in those with two or one null alleles relative to those with two active ..
  10. Homocysteine and Angiotensin II in Renovascular Remodeling
    Utpal Sen; Fiscal Year: 2013
    ..Renal function will be determined by measuring glomerular filtration rate (GFR)...
  11. Endogenous Cardiac Glycosides in AASK
    Brad C Astor; Fiscal Year: 2010
    ..sample of 255 AASK participants and coorelate these measures with markers of kidney function (estimated glomerular filtration rate, albuminuria), daytime and nighttime blood pressure, NT-proBNP, cardiac troponins I, and left ..
  12. Conservative Versus Dialytic Management in Stage V Chronic Kidney Disease
    GLENN MATTHEW CHERTOW; Fiscal Year: 2010
    ..of randomizing elderly (age >70 years) subjects with stage V chronic kidney disease (CKD) (estimated glomerular filtration rate (eGFR) 9 to <15 mL/min/1...
  13. Early Life Stress &Chronic Control of Blood Pressure
    Analia Loria; Fiscal Year: 2013
    ..Adult maternally separated (MS) rats show lower glomerular filtration rate under baseline conditions compared to control, un-separated littermates, with no difference in blood ..
  14. Early Life Stress &Chronic Control of Blood Pressure
    Analia Loria; Fiscal Year: 2013
    ..Adult maternally separated (MS) rats show lower glomerular filtration rate under baseline conditions compared to control, un-separated littermates, with no difference in blood ..
  15. PERL: A multicenter clinical trial of allopurinol to prevent GFR loss in T1D
    S MICHAEL MAUER; Fiscal Year: 2013
    ..To study whether uric acid lowering can reduce glomerular filtration rate (GFR) loss in T1D, we have established the PERL (Preventing Early Renal Function Loss in Diabetes) ..
  16. L-arginine supplement for the prevention of calcineurin inhibitor nephrotoxicity
    W Ray Kim; Fiscal Year: 2011
    ..Additionally, the effects of oral L-arginine on glomerular filtration rate, cardiac output, systemic vascular resistance, endothelial function, plasma arginine level and urinary ..
  17. Phenotypes of diabetic kidney disease and the relationship to retinal pathology
    Amy Mottl; Fiscal Year: 2013
    ..The predictive ability of retinopathy severity for albuminuria progression and decline in glomerular filtration rate (GFR) over four years will be analyzed...
  18. NITRIC OXIDE AND OXYGENATION IN DIABETIC KIDNEYS
    NILS AXEL FREDRIK PALM; Fiscal Year: 2010
    ..we will develop and validate protocol for noninvasive measurements of renal blood, oxygen usage and glomerular filtration rate by magnetic resonance...
  19. Insulin Resistance in Chronic Kidney Disease
    Ian H De Boer; Fiscal Year: 2013
    ..Moderate-severe CKD (stage 3-4, defined by glomerular filtration rate 15-59 mL/min/1...
  20. Novel Models of Diabetic Nephropathy
    Moshe Levi; Fiscal Year: 2010
    ..Phenotyping: In these mice we will determine a) the manifestation of diabetic nephropathy, including glomerular filtration rate, glomerulosclerosis, tubulointerstitial fibrosis, and proteinuria and b) the cellular and biochemical ..
  21. The ISCHEMIA-CKD Trial-CCC-Lead Application
    Sripal Bangalore; Fiscal Year: 2013
    ..ischemic heart disease (SIHD) patients with advanced chronic kidney disease (CKD) [defined as estimated glomerular filtration rate (eGFR) <30 mL/min/1.73m2) or on dialysis] and moderate-severe ischemia...
  22. Measurement of Renal Viscoelastic Properties with Ultrasound
    MATTHEW WILLIAM URBAN; Fiscal Year: 2013
    ..Noninvasive indicators of kidney disease including levels of serum creatinine, glomerular filtration rate, and classical medical imaging can provide certain insights into kidney disease state...
  23. Randomized trial of vitamin D and omega-3 fatty acids for diabetic kidney disease
    Ian H De Boer; Fiscal Year: 2013
    ..aim to test whether vitamin D3 and/or omega-3 fatty acids prevent progression of albuminuria and loss of glomerular filtration rate, two complementary manifestations of DKD, over 4 years of treatment...
  24. Effectiveness of Immediate vs. Delayed Use of Metformin in New-Onset T2 Diabetes
    JOE VANDIVER SELBY; Fiscal Year: 2010
    ..complications (new onset diabetic retinopathy, microalbuminuria, or rate of decline in estimated glomerular filtration rate). We recognize the risks of confounding inherent in observational approaches...
  25. RENALASE DEFICIENCY AND CARDIOVASCULAR COMPLICATIONS OF CHRONIC KIDNEY DISEASE
    Gary V Desir; Fiscal Year: 2010
    ..Blood renalase levels are inversely correlated with glomerular filtration rate (GFR) and markedly reduced in patients with advanced CKD, and end stage kidney disease (ESRD)...
  26. Gestational Stress and Impaired Iron Homeostasis in the Young Infant
    Christopher L Coe; Fiscal Year: 2013
    ..When infants are 8 months of age, measures of glomerular filtration rate and renal sympathetic input will be obtained...
  27. Predicting the burden of renal disease among liver transplant recipients
    Pratima Sharma; Fiscal Year: 2013
    ..provided by applicant): Post-liver transplant chronic renal failure (CRF), defined as estimated glomerular filtration rate (eGFR) <30 ml/min or end-stage renal disease (ESRD), is one of the major post-transplant co-..
  28. Ameliorating Sickle Nephropathy and Pulmonary Hypertension
    Punam Malik; Fiscal Year: 2013
    ..Children, and even infants with SCA develop a urine concentrating defect (UCD), increased glomerular filtration rate (GFR), supranormal proximal tubular function and impaired ability to excrete potassium...
  29. Disparities in Progression to Renal Replacement Therapy
    Stephen F Derose; Fiscal Year: 2011
    ..to ESRD and death from different starting points defined by kidney function, as measured by estimated glomerular filtration rate (eGFR). We will also examine the rate of change in kidney function...
  30. The Aging Kidney in HIV-Infection: biomarkers for early detection of injury
    Michael G Shlipak; Fiscal Year: 2013
    ..Kidney function estimates based on creatinine are unreliable until the glomerular filtration rate (GFR) has been substantially reduced;by this time, kidney disease is established and the primary ..
  31. Subclinical Renal Artery Atherosclerosis, Kidney Function and Hypertension
    Matthew A Allison; Fiscal Year: 2011
    ..are to determine if: 1) Renal artery calcium (RAC) is associated with kidney function, as measured by a) glomerular filtration rate, b) cystatin-C and 3) urine albumin;2) Both baseline and prospective changes in RAC are significantly ..
  32. ISCHEMIA-CKD SDCC
    SEAN M O'BRIEN; Fiscal Year: 2013
    ..ischemic heart disease (SIHD) patients with advanced chronic kidney disease (CKD) [defined as estimated glomerular filtration rate (eGFR) <30 mL/min/1.73m2) or on dialysis] and moderate-severe ischemia...
  33. Disordered Mineral Metabolism in the CKiD Children: Role of FGF-23
    Anthony A Portale; Fiscal Year: 2013
    ..FGF-23 levels increase progressively as glomerular filtration rate (GFR) declines in adults with CKD, before the development of hyperphosphatemia, and the increased FGF-23 ..
  34. Ambulatory Case and Preventable Hospitalizations in Diabetic Kidney Disease
    Chin Lin Tseng; Fiscal Year: 2013
    ..diabetes, we will establish a study cohort of patients in FY 2000-2006 with CKD, stage 2-4 (estimated glomerular filtration rate (eGFR) of 15-90 ml/min/1.73m2) and follow them for PQIs through FY 2009...
  35. Trajectories of Kidney Dysfunction in Older Adults with Chronic Kidney Disease
    CHRISTOPHER BARRETT BOWLING; Fiscal Year: 2013
    ..In the VA population, the prevalence of chronic kidney disease (CKD), defined as an estimated glomerular filtration rate (eGFR) <60 ml/min/1...
  36. Racial Differences in Phosphorus Metabolism in Health and in Kidney Disease
    ORLANDO M GUTIERREZ; Fiscal Year: 2012
    ..indicate that Blacks with CKD have a higher prevalence of hyperphosphatemia than Whites at all levels of glomerular filtration rate despite higher PTH levels, suggesting that Blacks have impaired Pi excreting capacity...
  37. Clinical Trial of the FAST Real-Time GFR System
    Bruce A Molitoris; Fiscal Year: 2011
    ..fluorescent device in humans and commercialize this device for rapid detection and quantification of glomerular filtration rate (GFR) in patients with acute kidney injury (AKI) and/or chronic kidney disease (CKD)...
  38. Accurate Measurement of Renal Function in Cirrhosis
    Vivian S Lee; Fiscal Year: 2013
    ..Over the past decade, we have developed 3D MR imaging and analysis tools for measuring glomerular filtration rate (GFR) using low doses of Gd contrast material and in less than 10 min of additional MR table time...
  39. The Aging Kidney: Chronic Injury, Impaired Functions and Clinical Outcomes
    Michael G Shlipak; Fiscal Year: 2013
    ..Despite these advances, however, little is known about how the aging process causes glomerular filtration rate (GFR) decline and the relationships of GFR loss to impairments of other critical functions of the kidney...
  40. Reasons for the Excess Mortality and Functional Decline in Older Adults with CKD
    CHRISTOPHER BARRETT BOWLING; Fiscal Year: 2013
    ..by applicant): The prevalence and incidence of chronic kidney disease (CKD), defined as an estimated glomerular filtration rate (eGFR) <60 ml/min/1.73m2, increases markedly with age...
  41. Sodium and Cardiovascular Disease in Patients with Chronic Kidney Disease
    Jiang He; Fiscal Year: 2010
    ..is an NIH-sponsored multi-center prospective cohort study that enrolled 3,689 adult patients with CKD (a glomerular filtration rate [GFR] from 20 to 70 ml/min based on patients'age) in the US and that will follow participants for ..
  42. Src Family Kinases and Control of Epithelial Cell Paracellular Permeability
    KURT F AMSLER; Fiscal Year: 2012
    ..I/R injury severity will be monitored by measuring parameters reflecting renal functional capacity, glomerular filtration rate (serum/urinary creatinine ratio), and proximal tubule cell structural integrity, Na+-K+-ATPase polarity...
  43. MR Angiography and Renography for Renovascular Disease
    Vivian S Lee; Fiscal Year: 2013
    ..a robust and quantitative low dose Gd-enhanced MR renography method for measuring single kidney glomerular filtration rate (GFR) and implemented a dual-injection method for ACE-inhibitor- enhanced MR renography to diagnose RVD...
  44. AT1 Receptors in Renal Microvascular Physiology
    LISA HARRISON BERNARD; Fiscal Year: 2009
    ..This chronic and debilitating disease is characterized by progressive albuminuria, declining glomerular filtration rate (GFR), and increased risk for cardiovascular disease, eventually requiring dialysis...
  45. Safety and Effectiveness Evaluations for Kidney Disease in Complex Patients
    DONALD READ MILLER; Fiscal Year: 2010
    ..comparative effectiveness and safety in slowing the progression of kidney disease (decline in estimated glomerular filtration rate (eGFR), transition in CKD stage, transition to ESRD), reducing risks of other outcomes (CVD events, ..
  46. Multi-factorial Intervention to Slow Progression of Diabetic Kidney Disease
    Uptal D Patel; Fiscal Year: 2013
    ..The primary outcome is change in estimated glomerular filtration rate after 3 years...
  47. The health status of Caucasian and African American living with kidney donors
    Sandra J Taler; Fiscal Year: 2010
    ..the presence of CV risk factors and measure surrogate markers for renal and CV disease, (c) Carry out glomerular filtration rate (GFR) measurements using iothalamate clearance on donors returning for in-center follow-up and examine ..
  48. Kidney Function and Aging
    Lesley Ann Inker; Fiscal Year: 2012
    ..b>Glomerular filtration rate (GFR) declines with age and low GFR defines chronic kidney disease (CKD)...
  49. FGF-23 and clinical outcomes in ADPKD patients
    MYLES S WOLF; Fiscal Year: 2013
    ..the Chronic Renal Insufficiency Cohort (CRIC) studies that are frequency matched by race and estimated glomerular filtration rate. In the second aim, we will perform the first ever bone biopsy study dedicated to ADPKD to investigate ..
  50. AGE-RELATED CHANGES IN RENAL MORPHOLOGY AND FUNCTION IN CHRONIC KIDNEY DISEASE
    Yu Chen; Fiscal Year: 2013
    ..CKD is a decline in renal function defined by decreased glomerular filtration rate (GFR)...
  51. Racial and Cardiovascular Risk Factor Anomalies in CKD
    CSABA PAL KOVESDY; Fiscal Year: 2013
    ..risk factor profiles by examining longitudinally a cohort of patients with normal estimated glomerular filtration rate. We will explore the effects of various socio-demographic characteristics, co-morbidities, biochemical ..
  52. A Pilot Study Validating Novel Algorithm for Kidney Disease
    Abhijit V Kshirsagar; Fiscal Year: 2010
    ..generated risk scores as well as their standard screening protocol risk scores with the estimated glomerular filtration rate (based on serum creatinine), we will be able to assess the efficacy of the less expensive and less ..
  53. Early-Stage Chronic Kidney Disease in HIV-infected Individuals
    Gregory M Lucas; Fiscal Year: 2013
    ..equal numbers of HIV-infected and HIV-negative individuals with normal kidney function (estimated glomerular filtration rate (GFR) >60 mL/min/1...
  54. CRIC Ancillary Study: Carbamylated low-density lipoprotein and cardiovascular eve
    Sudhir V Shah; Fiscal Year: 2011
    ..determine the relationship between serum cLDL and serum urea and/or level of renal function (estimated glomerular filtration rate [eGFR])...
  55. Plasma Osteoprotegerin and Adverse Outcomes in CHD Patients
    Iftikhar J Kullo; Fiscal Year: 2013
    ..stroke, and heart failure) independent of age, sex, ethnicity, conventional risk factors, and estimated glomerular filtration rate. In addition, we will assess whether any association of plasma OPG with adverse events is independent of ..
  56. Renal Processing of Albumin
    Oliver Smithies; Fiscal Year: 2010
    ..The glomerular filtration rate (GFR) clearly governs all trans-glomerular water transport, but calculations by me and others indicate ..
  57. Biological Mechanism of INF2-mediated FSGS
    Martin R Pollak; Fiscal Year: 2013
    ..which when mutated leads to a form of progressive kidney disease characterized by proteinuria, reduced glomerular filtration rate, and a histologic pattern of injury characterized by focal and segmental glomerulosclerosis (FSGS)...
  58. Oral Sodium Bicarbonate to Slow Chronic Kidney Disease Progression
    KALANI LUKELA RAPHAEL; Fiscal Year: 2013
    ..efficacy results will not preclude the planning of a large trial, since positive results using glomerular filtration rate as an outcome have already been demonstrated in previous small trials...
  59. PDE5i with Tadalafil Changes the Extent of Renal Damage (PITCH_ER)
    Ravi Thadhani; Fiscal Year: 2013
    ..Both chronic kidney disease (CKD) (reflected by albuminuria and reduced glomerular filtration rate [GFR]) and acute kidney injury (AKI) significantly contribute to morbidity and mortality in patients ..
  60. Monitoring transplant kidney function with MRI
    SEAN BEDILION FAIN; Fiscal Year: 2010
    ..Currently serum creatinine (Scr), estimated glomerular filtration rate (eGFR) and proteinuria are used to monitor kidney function in transplant recipients...
  61. ASSESSING LONG TERM OUTCOMES OF LIVING DONATION
    Bertram L Kasiske; Fiscal Year: 2013
    ..ALTOLD measured iohexol glomerular filtration rate (GFR) and traditional cardiovascular disease (CVD) risk factors pre- and 6, 12, 24 and 36 months post-..
  62. AORTA, BRAIN AND KIDNEY STRUCTURE AND FUNCTION IN THE AGES-REYKJAVIK STUDY
    GARY FRANK MITCHELL; Fiscal Year: 2012
    ..function are associated with abnormal brain and kidney structure (MRI) and function (cognitive testing, glomerular filtration rate, albuminuria)...
  63. Renal Control of Blood Pressure in Early Diabetes
    Michael Brands; Fiscal Year: 2007
    ..Our L-NAME, ACh, and glomerular filtration rate (GFR) data support this, but to better implicate NO and define the site(s) for its control of renal ..
  64. RENIN-ANGIOTENSIN AND GROWTH IN URETERAL OBSTRUCTION
    ROBERT CHEVALIER; Fiscal Year: 1991
    ..Neonatal and adult rats will be subjected to UUO or sham operation, and renal blood flow, glomerular filtration rate, and renal renin content will be measured...
  65. PHYSIOLOGIC RESPONSE TO THERMAL INJURY
    EDWARD PAVLIN; Fiscal Year: 1990
    ..g. increases in basal metabolic rate, cardiac output and glomerular filtration rate. Physiologic responses to thermal injury result in altered requirements for many different types of ..
  66. CLINICAL PHARMACOLOGY CENTER
    Michael Murphy; Fiscal Year: 1991
    ..of Endogenous DA in Renal Function" are 1) to determine the effects of NaC1 loading on renal blood flow, glomerular filtration rate, and electrolyte and DA excretion in dogs before and after administration of DA1 and DA2 receptor ..
  67. ATRIAL NATRIURETIC PEPTIDE IN RENAL GROWTH
    ROBERT CHEVALIER; Fiscal Year: 1990
    During normal renal growth, renal blood flow (RBF) and glomerular filtration rate (GFR) rise, while the efficiency of urine sodium excretion (UNaV) and diuresis following acute volume expansion also increase...
  68. REGULATION OF RENAL VASCULAR CELLS IN HYPERTENSION
    CRAIG GELBAND; Fiscal Year: 1999
    The relationship between renal blood flow and glomerular filtration rate is well established...
  69. Biomakers in Sickle Cell Anemia: Response to Hydroxyurea
    Marie Stuart; Fiscal Year: 2004
    ..Organ evaluations will include splenic scintigraphy and pitted red cell counts; glomerular filtration rate, and evaluation for microalbuminuria and urine concentrating ability; brain MRI/MRA and transcranial ..
  70. Chronic Kidney Disease and Cardiovascular Risk in Black and White Young Adults
    Kirsten Bibbins Domingo; Fiscal Year: 2010
    ..are disproportionately affected by kidney disease, exhibiting high rates of age-adjusted incident CKD (glomerular filtration rate [GFR] <60 ml/min/1...
  71. THE MODIFICATION OF DIET IN RENAL DISEASE (MDRD) STUDY
    Lawrence Hunsicker; Fiscal Year: 1993
    ..observation, patients may be entered into one of two branches of the trial depending upon initial glomerular filtration rate (GFR) measured as urinary clearance of 125I-iothalamate...
  72. PATHOBIOLOGY OF GLOMERULAR INJURY IN TYPE II DIABETES
    Timothy Meyer; Fiscal Year: 1993
    ..This study provides for Pima Indians in Arizona to undergo clearance studies to (1) determine the glomerular filtration rate (GFR) and elucidate its determinants; and (2) characterize the abnormality of glomerular barrier ..
  73. Chronic Renal Disease-Individual Patient Meta Analysis
    Andrew Levey; Fiscal Year: 2007
    ..to the diagnosis and management of patients with chronic kidney disease - estimation of kidney function (glomerular filtration rate, GFR) from serum measurements...